Identification

Name
Somatotropin
Accession Number
DB00052  (BTD00086, BIOD00086, DB06417)
Type
Biotech
Groups
Approved, Investigational
Biologic Classification
Protein Based Therapies
Hormones
Description

Recombinant human growth hormone (somatotropin) 191 residues, MW 22.1 kD, synthesized in E. coli

Protein structure
Db00052
Protein chemical formula
C990H1532N262O300S7
Protein average weight
22129.0 Da
Sequences
>DB00052 sequence
FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPT
PSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEG
IQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIV
QCRSVEGSCGF
Download FASTA Format
Synonyms
  • Growth hormone
  • Growth hormone (human)
  • hGH
  • Human growth hormone
  • Recombinant human growth hormone
  • rhGH
  • Somatotropin (human)
  • Somatotropin human
  • Somatotropin human growth hormone
  • Somatropin
  • Somatropin (rDNA origin)
  • Somatropin (recombinant DNA origin)
  • Somatropin [rDNA origin]
  • Somatropin recombinant
  • Somatropin(recombinant DNA origin)
External IDs
CB-311 / DA-3002 / LY-137998 / LY137998
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
GenotropinPowder, for solution1.2 mgSubcutaneousPfizer2013-09-18Not applicableCanada
GenotropinKitPharmacia & Upjohn Inc1995-12-20Not applicableUs
GenotropinPowder, for solution12 mgSubcutaneousPfizer2013-09-18Not applicableCanada
GenotropinKitPharmacia & Upjohn Inc1995-12-20Not applicableUs
GenotropinPowder, for solution1.0 mgSubcutaneousPfizer2013-09-18Not applicableCanada
GenotropinKitPharmacia & Upjohn Inc1995-12-20Not applicableUs
GenotropinPowder, for solution1.8 mgSubcutaneousPfizer2013-09-18Not applicableCanada
GenotropinKitPharmacia & Upjohn Inc1995-12-20Not applicableUs
GenotropinPowder, for solution0.2 mgSubcutaneousPfizerNot applicableNot applicableCanada
GenotropinKitPharmacia & Upjohn Inc1995-12-20Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ValtropinInjection, powder, for solution15 mg/1.5mlSubcutaneousBio Partners Gmb H2006-04-24Not applicableEu
International/Other Brands
BioTropin (Biotech General) / NutropinAQ (Genentech Inc.)
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Bio-tropinSomatotropin (4.8 mg) + Sodium Chloride (10 ml)Liquid; Powder, for solutionSubcutaneousNovopharm LimitedNot applicableNot applicableCanada
Bio-tropinSomatotropin (1.8 mg) + Sodium Chloride (10 ml)Liquid; Powder, for solutionSubcutaneousNovopharm LimitedNot applicableNot applicableCanada
HumatropeSomatotropin (6 mg)Liquid; Powder, for solutionIntramuscular; SubcutaneousEli Lilly & Co. Ltd.2001-09-25Not applicableCanada
HumatropeSomatotropin (12 mg)Liquid; Powder, for solutionIntramuscular; SubcutaneousEli Lilly & Co. Ltd.2001-08-28Not applicableCanada
HumatropeSomatotropin (24 mg)Liquid; Powder, for solutionIntramuscular; SubcutaneousEli Lilly & Co. Ltd.2003-12-08Not applicableCanada
Nutropin - Kit Pws(10mg) & Liq(10ml) Im ScSomatotropin (10 mg) + Water (10 ml)Kit; Powder, for solutionIntramuscular; SubcutaneousHoffmann La Roche2002-10-082013-12-02Canada
Nutropin - Kit Pws(5mg) & Liq(10ml) Im ScSomatotropin (5 mg) + Water (10 ml)Kit; Powder, for solutionIntramuscular; SubcutaneousHoffmann La Roche1997-01-202011-07-19Canada
OmnitropeSomatotropin (5.8 mg) + Water (1.14 ml)Kit; Powder, for solutionSubcutaneousSandoz Canada IncorporatedNot applicableNot applicableCanada
Saizen 10iu - KitSomatotropin (3.3 mg) + Sodium Chloride (5 ml)Powder, for solutionIntramuscular; SubcutaneousEmd Serono, A Division Of Emd Inc., Canada1996-10-17Not applicableCanada
SerostimSomatotropin (5 mg) + Water (1 ml)Powder, for solutionSubcutaneousEmd Serono, A Division Of Emd Inc., Canada1999-07-28Not applicableCanada
Categories
UNII
NQX9KB6PCL
CAS number
12629-01-5

Pharmacology

Indication

For treatment of dwarfism, acromegaly and prevention of HIV-induced weight loss

Structured Indications
Pharmacodynamics

Used in the treatment of dwarfism and growth failure, growth hormone (hGH) stimulates skeletal growth in pediatric patients with growth failure due to a lack of adequate secretion of endogenous GH. Skeletal growth is accomplished at the epiphyseal plates at the ends of a growing bone. Growth and metabolism of epiphyseal plate cells are directly stimulated by GH and one of its mediators, IGF-I (insulin-like growth factor).

Mechanism of action

hGH binds to the human growth hormone receptor (GHR). Upon binding, hGH causes dimerization of GHR, activation of the GHR-associated JAK2 tyrosine kinase, and tyrosyl phosphorylation of both JAK2 and GHR. These events recruit and/or activate a variety of signaling molecules, including MAP kinases, insulin receptor substrates, phosphatidylinositol 3' phosphate kinase, diacylglycerol, protein kinase C, intracellular calcium, and Stat transcription factors. These signaling molecules contribute to the GH-induced changes in enzymatic activity, transport function, and gene expression that ultimately culminate in changes in growth and metabolism.

TargetActionsOrganism
AGrowth hormone receptor
binder
Human
AProlactin receptorNot AvailableHuman
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination

Although calcium excretion in the urine is increased, there is a simultaneous increase in calcium absorption from the intestine. Somatropin stimulates the synthesis of chondroitin sulfate and collagen, and increases the urinary excretion of hydroxyproline.

Half life
Not Available
Clearance
  • 2.3 +/- 1.8 mL/min/kg [GHD patients (IV 33 ng/kg/min)]
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
ChlorotrianiseneThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Chlorotrianisene.Investigational, Withdrawn
Conjugated estrogensThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Conjugated estrogens.Approved
Cortisone acetateThe therapeutic efficacy of Cortisone acetate can be decreased when used in combination with Somatotropin.Approved
DaidzeinThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Daidzein.Experimental
DienestrolThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Dienestrol.Approved, Investigational
DiethylstilbestrolThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Diethylstilbestrol.Approved, Investigational
EpimestrolThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Epimestrol.Experimental
EquolThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Equol.Investigational
EstradiolThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Estradiol.Approved, Investigational, Vet Approved
EstriolThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Estriol.Approved, Investigational, Vet Approved
Estrogens, esterifiedThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Estrogens, esterified.Approved
EstroneThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Estrone.Approved
Ethinyl EstradiolThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Ethinyl Estradiol.Approved
GenisteinThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Genistein.Investigational
HexestrolThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Hexestrol.Withdrawn
MestranolThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Mestranol.Approved
MethallenestrilThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Methallenestril.Experimental
MoxestrolThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Moxestrol.Experimental
Polyestradiol phosphateThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Polyestradiol phosphate.Approved
PrednisoneThe therapeutic efficacy of Prednisone can be decreased when used in combination with Somatotropin.Approved, Vet Approved
PromestrieneThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Promestriene.Investigational
QuinestrolThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Quinestrol.Approved
SecoisolariciresinolThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Secoisolariciresinol.Investigational
Synthetic Conjugated Estrogens, AThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Synthetic Conjugated Estrogens, A.Approved
Synthetic Conjugated Estrogens, BThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Synthetic Conjugated Estrogens, B.Approved
TiboloneThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Tibolone.Approved, Investigational
ZeranolThe therapeutic efficacy of Somatotropin can be decreased when used in combination with Zeranol.Vet Approved
Food Interactions
Not Available

References

Synthesis Reference

Mandayam J. Narasimhan, John A. Anderson, "Process for the large scale production of human growth hormone by serial secondary suspension culture." U.S. Patent US4124448, issued January, 1963.

US4124448
General References
  1. Seltzer V, Tonge SR: Proceedings: Methylamphetamine withdrawal as a model for the depressive state: antagonism of post-amphetamine depression by imipramine. J Pharm Pharmacol. 1975 Dec;27 Suppl?-2:16P. [PubMed:2688]
  2. Alba-Roth J, Muller OA, Schopohl J, von Werder K: Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. J Clin Endocrinol Metab. 1988 Dec;67(6):1186-9. [PubMed:2903866]
  3. Scarth JP: Modulation of the growth hormone-insulin-like growth factor (GH-IGF) axis by pharmaceutical, nutraceutical and environmental xenobiotics: an emerging role for xenobiotic-metabolizing enzymes and the transcription factors regulating their expression. A review. Xenobiotica. 2006 Feb-Mar;36(2-3):119-218. [PubMed:16702112]
  4. Takahashi Y, Kipnis DM, Daughaday WH: Growth hormone secretion during sleep. J Clin Invest. 1968 Sep;47(9):2079-90. [PubMed:5675428]
External Links
UniProt
P58756
Genbank
AF374232
PubChem Substance
46506010
ChEMBL
CHEMBL1201621
Therapeutic Targets Database
DAP001054
PharmGKB
PA451446
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Somatropin_recombinant
ATC Codes
H01AC01 — Somatropin
AHFS Codes
  • 68:28.00 — Pituitary
  • 68:30.04 — Somatotropin Agonists*
FDA label
Download (241 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0Active Not RecruitingTreatmentAging / Immune System and Related Disorders1
0CompletedTreatmentGrowth Hormone Deficiency (GHD)1
0RecruitingTreatmentInfertility, Female1
0RecruitingTreatmentNAFLD1
1Active Not RecruitingDiagnosticTraumatic Brain Injury (TBI)1
1CompletedBasic ScienceCardiovascular Disease (CVD)1
1CompletedBasic ScienceGrowth Failure / Growth Hormone Deficiency (GHD)1
1CompletedTreatmentAdult Growth Hormone Deficiency (AGHD) / Growth Hormone Disorders1
1CompletedTreatmentAdult Growth Hormone Deficiency (AGHD) / Growth Hormone Disorders / Healthy Volunteers1
1CompletedTreatmentChronic Kidney Disease (CKD) / End-Stage Renal Disease (ESRD) / Healthy Volunteers1
1CompletedTreatmentGenetic Disorders / Growth Disorders / Healthy Volunteers / Idiopathic Short Stature (ISS) / Prader-Willi Syndrome1
1CompletedTreatmentGrowth Disorders / Healthy Volunteers1
1CompletedTreatmentGrowth Hormone Deficiency (GHD)3
1CompletedTreatmentGrowth Hormone Deficiency in Children / Growth Hormone Disorders1
1CompletedTreatmentGrowth Hormone Disorders / Healthy Volunteers1
1CompletedTreatmentHealthy Volunteers2
1TerminatedNot AvailableAllogeneic Stem Cell Transplantation1
1TerminatedTreatmentTurner's Syndrome1
1Unknown StatusTreatmentGH Deficiency (GHD) / Problems of growth and stature1
1Unknown StatusTreatmentGrowth Disorders / Hypophosphatemic Rickets / Somatropin Therapy1
1WithdrawnTreatmentGrowth Disorders / Healthy Volunteers1
1, 2Enrolling by InvitationTreatmentFemale Infertility Due to Diminished Ovarian Reserve1
1, 2Not Yet RecruitingTreatmentShort Stature1
2Active Not RecruitingTreatmentGrowth Hormone Deficiency (GHD)1
2CompletedTreatmentAdult Growth Hormone Deficiency (AGHD)2
2CompletedTreatmentAmyotrophic Lateral Sclerosis (ALS)1
2CompletedTreatmentAnorexia Nervosa (AN) / Bone destruction / Eating Disorders / Osteopenia1
2CompletedTreatmentBMI >30 kg/m21
2CompletedTreatmentChronic Heart Failure (CHF) / Growth Hormone Deficiency (GHD)1
2CompletedTreatmentChronic Kidney Disease (CKD) / End-Stage Renal Disease (ESRD)1
2CompletedTreatmentCystic Fibrosis (CF)1
2CompletedTreatmentDwarfism / Turner's Syndrome1
2CompletedTreatmentEnd Stage Renal Disease (ESRD)1
2CompletedTreatmentFractures, Bone / Tibia Fractures1
2CompletedTreatmentFrailty / Muscle Weakness / Sarcopenia1
2CompletedTreatmentGonadal Dysgenesis / Turner's Syndrome1
2CompletedTreatmentGrowth Hormone Deficiency (GHD)3
2CompletedTreatmentGrowth Hormone Deficiency (GHD) / Heart Failure, Unspecified / Ischaemic Heart Diseases1
2CompletedTreatmentGrowth Hormone Deficiency in Children / Growth Hormone Disorders1
2CompletedTreatmentGrowth Hormone Deficient Adults1
2CompletedTreatmentGrowth Hormone Therapy / Very Low Birth Weight Infant1
2CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
2CompletedTreatmentHypochondroplasia1
2CompletedTreatmentIdiopathic Short Stature (ISS)1
2CompletedTreatmentInfertilities / Poor Ovarian Reserve1
2CompletedTreatmentMuscular Atrophy, Spinal1
2CompletedTreatmentPediatric Growth Hormone Deficiency1
2CompletedTreatmentShort Bowel Syndrome (SBS)1
2CompletedTreatmentTraumatic Brain Injury (TBI)1
2Enrolling by InvitationTreatmentRupture of Anterior Cruciate Ligament1
2Not Yet RecruitingBasic ScienceTendinopathy1
2Not Yet RecruitingTreatmentGrowth Hormone Treatment / Infant, Premature, Diseases / Infant, Small for Gestational Age1
2SuspendedTreatmentComplications; Artificial Fertilization, Introduction of Embryo in Embryo Transfer1
2TerminatedTreatmentGrowth Hormone-Deficiency1
2TerminatedTreatmentHormone Deficiency1
2TerminatedTreatmentInsulin-Like Growth Factor-1 Deficiency1
2Unknown StatusTreatmentGrowth Hormone Deficiency (GHD)1
2, 3CompletedNot AvailableAcute Lymphoblastic Leukaemias (ALL) / Leukemia Acute Myeloid Leukemia (AML) / Multiple Myeloma (MM) / Myelodysplastic Syndrome1
2, 3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Human Immunodeficiency Virus-associated Adipose Redistribution Syndrome (HARS)2
2, 3CompletedTreatmentShort Stature1
2, 3CompletedTreatmentMinor burns1
2, 3RecruitingTreatmentGrowth Hormone Treatment / Minor burns1
2, 3RecruitingTreatmentMinor burns1
2, 3TerminatedTreatmentArthritis, Juvenile Rheumatoid / Crohn's Disease (CD)1
2, 3TerminatedTreatmentInfertilities1
2, 3TerminatedTreatmentMucopolysaccharidosis II / Mucopolysaccharidosis VI / Type 1 Mucopolysaccharidosis1
2, 3Unknown StatusTreatmentHuman Immunodeficiency Virus (HIV) Infections1
3Active Not RecruitingTreatmentAdult Growth Hormone Deficiency (AGHD) / Growth Hormone Disorders2
3Active Not RecruitingTreatmentGenetic Disorders / Noonan Syndrome1
3CompletedNot AvailableDiabetes1
3CompletedNot AvailableFoetal Growth Problem / Small for Gestational Age1
3CompletedTreatmentAdult Growth Hormone Deficiency (AGHD)1
3CompletedTreatmentAdult Growth Hormone Deficiency (AGHD) / Growth Hormone Disorders5
3CompletedTreatmentBMI >30 kg/m2 / Metabolic Syndromes / Obesity, Abdominal1
3CompletedTreatmentChildhood-onset Growth Hormone Deficiency / Pituitary Dwarfism1
3CompletedTreatmentChildren Born With Serious Intra-uterine Growth Retardation1
3CompletedTreatmentDwarfism / Pituitary Diseases / Renal Insufficiency,Chronic / Turner's Syndrome1
3CompletedTreatmentEndocrine System Diseases1
3CompletedTreatmentFailure to Thrive1
3CompletedTreatmentFibromyalgia1
3CompletedTreatmentFoetal Growth Problem / Small for Gestational Age4
3CompletedTreatmentGenetic Disorders / Growth Hormone Deficiency in Children / Growth Hormone Disorders / Turner's Syndrome1
3CompletedTreatmentGenetic Disorders / Noonan Syndrome2
3CompletedTreatmentGenetic Disorders / Turner's Syndrome1
3CompletedTreatmentGrowth Disorders1
3CompletedTreatmentGrowth Disorders / Growth Hormone Deficiency in Children / Growth Hormone Disorders / Idiopathic Short Stature (ISS)1
3CompletedTreatmentGrowth Disorders / Idiopathic Short Stature (ISS)1
3CompletedTreatmentGrowth Hormone Deficiency (GHD)6
3CompletedTreatmentGrowth Hormone Deficiency (GHD) / Problems of growth and stature1
3CompletedTreatmentGrowth Hormone Deficiency in Children / Growth Hormone Disorders1
3CompletedTreatmentGrowth Hormone Disorders / Pituitary Dwarfism1
3CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Lipodystrophies1
3CompletedTreatmentHuman Immunodeficiency Virus-Associated Adipose Redistribution Syndrome1
3CompletedTreatmentIdiopathic Growth Hormone Deficiency1
3CompletedTreatmentIdiopathic Short Stature (ISS)5
3CompletedTreatmentInfant, Small for Gestational Age1
3CompletedTreatmentIntrauterine Growth Retardation2
3CompletedTreatmentJuvenile Idiopathic Arthritis (JIA) / Still Disease, Juvenile-Onset1
3CompletedTreatmentKidney Failure,Chronic / Renal Dialysis1
3CompletedTreatmentOsteogenesis Imperfecta1
3CompletedTreatmentShort Bowel Syndrome (SBS)1
3CompletedTreatmentSmall For Gestational Age (SGA) / Small Gestational Age (SGA)1
3CompletedTreatmentTurner's Syndrome3
3RecruitingTreatmentEndocrine System Diseases / Growth Hormone Deficiency, Pediatric / HGH (Human Growth Hormone) / Hormones / Pituitary Diseases1
3RecruitingTreatmentInfant, Small for Gestational Age2
3RecruitingTreatmentPediatric Growth Hormone Deficiency1
3RecruitingTreatmentPrader-Willi Syndrome1
3TerminatedTreatmentChronic Kidney Disease (CKD) / End-Stage Renal Disease (ESRD)1
3TerminatedTreatmentEndocrine System Diseases2
3TerminatedTreatmentGrowth Hormone Deficiency (GHD)4
3TerminatedTreatmentGrowth Hormone Therapy / Infant, Small for Gestational Age1
3TerminatedTreatmentInfant, Small for Gestational Age1
3Unknown StatusTreatmentGrowth Hormone Deficiency (GHD)1
3Unknown StatusTreatmentTurner's Syndrome1
4Active Not RecruitingTreatmentGrowth Hormone Deficiency (GHD)1
4Active Not RecruitingTreatmentIdiopathic Short Stature (ISS)1
4Active Not RecruitingTreatmentIdiopathic Short Stature (ISS) / Self Image1
4Active Not RecruitingTreatmentSmall for Gestational Age1
4CompletedNot AvailableGrowth Disorders1
4CompletedBasic ScienceGrowth Hormone Deficiency (GHD)1
4CompletedTreatmentAdult Growth Hormone Deficiency (AGHD)1
4CompletedTreatmentAdult Growth Hormone Deficiency (AGHD) / Growth Hormone Disorders1
4CompletedTreatmentBMI >30 kg/m21
4CompletedTreatmentChronic Kidney Disease (CKD) / Chronic Renal Insufficiency1
4CompletedTreatmentDwarfism / Growth Hormone Deficiency (GHD)1
4CompletedTreatmentFemale Infertility Due to Diminished Ovarian Reserve2
4CompletedTreatmentFoetal Growth Problem / Small for Gestational Age3
4CompletedTreatmentGenetic Disorders / Turner's Syndrome2
4CompletedTreatmentGrowth Hormone Deficiency (GHD)1
4CompletedTreatmentGrowth Hormone Deficiency (GHD) / Traumatic Brain Injury (TBI)1
4CompletedTreatmentGrowth Hormone Deficiency in Children / Growth Hormone Disorders1
4CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
4CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Lipodystrophies1
4CompletedTreatmentHypopituitarism1
4CompletedTreatmentHypothyroidism1
4CompletedTreatmentPituitary Dwarfism1
4CompletedTreatmentShort Bowel Syndrome (SBS)1
4CompletedTreatmentShort Stature Born Small for Gestational Age (SGA)1
4CompletedTreatmentTurner's Syndrome1
4RecruitingTreatmentChronic Renal Failure (CRF) / Growth Hormone Deficiency (GHD) / Infant, Small for Gestational Age / Short Stature, Idiopathic / Turner's Syndrome1
4RecruitingTreatmentInfertilities1
4SuspendedDiagnosticChronic Renal Insufficiency1
4TerminatedNot AvailableIdiopathic Short Stature (ISS) / Turner's Syndrome1
4TerminatedTreatmentAdult Growth Hormone Deficiency (AGHD) / Growth Hormone Disorders1
4TerminatedTreatmentBrain Injury / Growth Hormone Deficiency (GHD)1
4TerminatedTreatmentChronic Kidney Disease (CKD)1
4TerminatedTreatmentSmall for Gestational Age1
4Unknown StatusNot AvailableIntrauterine Growth Retardation1
4Unknown StatusDiagnosticAtaxia Telangiectasia (AT) / Growth Failure1
4Unknown StatusSupportive CareTraumatic Brain Injury (TBI)1
4WithdrawnDiagnosticIdiopathic Short Stature (ISS)1
Not AvailableActive Not RecruitingNot AvailableFoetal Growth Problem / Small for Gestational Age1
Not AvailableActive Not RecruitingNot AvailableGrowth Disorders / Small for Gestational Age1
Not AvailableActive Not RecruitingDiagnosticGrowth Hormone Deficiency (GHD)1
Not AvailableActive Not RecruitingOtherBMI >30 kg/m2 / Osteopenia1
Not AvailableCompletedNot AvailableAchondroplasia / Genetic Disorders2
Not AvailableCompletedNot AvailableAdrenal; Functional Disturbance / Growth Hormone Treatment1
Not AvailableCompletedNot AvailableAdult Growth Hormone Deficiency (AGHD) / Chronic Kidney Disease (CKD) / Chronic Renal Insufficiency / Foetal Growth Problem / Genetic Disorders / Growth Hormone Deficiency in Children / Growth Hormone Disorders / Noonan Syndrome / Small for Gestational Age / Turner's Syndrome1
Not AvailableCompletedNot AvailableAdult Growth Hormone Deficiency (AGHD) / Growth Hormone Disorders4
Not AvailableCompletedNot AvailableChronic Kidney Disease (CKD) / Chronic Renal Insufficiency / Delivery Systems / Foetal Growth Problem / Genetic Disorders / Growth Hormone Deficiency in Children / Growth Hormone Disorders / Small for Gestational Age / Turner's Syndrome1
Not AvailableCompletedNot AvailableFoetal Growth Problem / Genetic Disorders / Growth Disorders / Growth Hormone Deficiency in Children / Growth Hormone Disorders / Idiopathic Short Stature (ISS) / Small for Gestational Age / Turner's Syndrome1
Not AvailableCompletedNot AvailableGenetic Disorders / Growth Hormone Deficiency in Children / Growth Hormone Disorders / Turner's Syndrome1
Not AvailableCompletedNot AvailableGenetic Disorders / Prader-Willi Syndrome1
Not AvailableCompletedNot AvailableGrowth Hormone Deficiency Dwarfism1
Not AvailableCompletedNot AvailableGrowth Hormone Deficiency Dwarfism / Infant, Small for Gestational Age / SHOX Protein, Human / Turner's Syndrome1
Not AvailableCompletedNot AvailableGrowth Hormone Deficiency, Adult / Hypopituitarism / Pituitary Insufficiency1
Not AvailableCompletedNot AvailableGrowth Hormone Disorders / Hypopituitarism / Pituitary Dwarfism1
Not AvailableCompletedNot AvailableHuman Growth Hormone Deficiency / Turner's Syndrome1
Not AvailableCompletedNot AvailableInfant, Small for Gestational Age1
Not AvailableCompletedNot AvailableShort Stature / Turner's Syndrome1
Not AvailableCompletedNot AvailableSmall For Gestational Age (SGA)1
Not AvailableCompletedNot AvailableSmall for Gestational Age1
Not AvailableCompletedBasic ScienceAcromegaly / Metabolic Diseases1
Not AvailableCompletedBasic ScienceDiabetes, Diabetes Mellitus Type 1 / Ketoacidosis1
Not AvailableCompletedBasic ScienceFatty Liver / Metabolism1
Not AvailableCompletedBasic ScienceGrowth Hormone Deficiency (GHD)2
Not AvailableCompletedBasic ScienceHealthy Volunteers2
Not AvailableCompletedBasic ScienceIntracellular Signaling Peptides and Proteins1
Not AvailableCompletedTreatmentAcquired Immune Deficiency Syndrome (AIDS) / Human Immunodeficiency Virus (HIV) Infections1
Not AvailableCompletedTreatmentAcromegaly / Growth Hormone Deficiency (GHD) / Pituitary Diseases1
Not AvailableCompletedTreatmentGrowth Hormone Deficiency (GHD)1
Not AvailableCompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections2
Not AvailableCompletedTreatmentPrader-Willi Syndrome1
Not AvailableNot Yet RecruitingNot AvailableGrowth Disorders1
Not AvailableRecruitingNot AvailableGrowth Hormone Deficiency (GHD)1
Not AvailableRecruitingBasic ScienceGrowth Hormone Treatment / Metabolic Diseases1
Not AvailableRecruitingTreatmentNonalcoholic Fatty Liver Disease (NAFLD)1
Not AvailableTerminatedNot AvailableGrowth Hormone Deficiency (GHD) / Idiopathic Short Stature (ISS)1
Not AvailableTerminatedNot AvailableGrowth Hormone Deficiency (GHD) / Turner's Syndrome1
Not AvailableTerminatedDiagnosticGrowth Hormone Deficiency (GHD)1
Not AvailableUnknown StatusBasic ScienceInteraction Between the GH/IGF-I System and the Immune-system1
Not AvailableUnknown StatusBasic ScienceTurner's Syndrome1
Not AvailableWithdrawnNot AvailableGrowth Hormone Deficiency (GHD)1
Not AvailableWithdrawnTreatmentMetabolic Syndromes1
Not AvailableWithdrawnTreatmentPolycystic Ovaries Syndrome1

Pharmacoeconomics

Manufacturers
  • Genentech inc
  • Serono laboratories inc
  • Cangene corp
  • Ferring pharmaceuticals inc
  • Pharmacia and upjohn co
  • Eli lilly and co
  • Novo nordisk inc
  • Sandoz inc
  • Emd serono inc
  • Lg life sciences ltd
Packagers
Dosage forms
FormRouteStrength
Liquid; powder, for solutionSubcutaneous
Powder, for solutionSubcutaneous0.2 mg
Powder, for solutionSubcutaneous0.4 mg
Powder, for solutionSubcutaneous0.6 mg
Powder, for solutionSubcutaneous0.8 mg
Powder, for solutionSubcutaneous1.0 mg
Powder, for solutionSubcutaneous1.2 mg
Powder, for solutionSubcutaneous1.4 mg
Powder, for solutionSubcutaneous1.6 mg
Powder, for solutionSubcutaneous1.8 mg
Powder, for solutionSubcutaneous12 mg
Powder, for solutionSubcutaneous2.0 mg
Powder, for solutionSubcutaneous5 mg
Powder, for solutionSubcutaneous5.3 mg
Liquid; powder, for solutionIntramuscular; Subcutaneous
Powder, for solutionIntramuscular; Subcutaneous1 mg
Injection, solutionSubcutaneous10 mg/1.5mL
Injection, solutionSubcutaneous15 mg/1.5mL
Injection, solutionSubcutaneous30 mg/3mL
Injection, solutionSubcutaneous5 mg/1.5mL
SolutionSubcutaneous15 mg
Kit
Kit; powder, for solutionIntramuscular; Subcutaneous
LiquidSubcutaneous5 mg
SolutionSubcutaneous20 mg
Injection, solutionSubcutaneous5 mg/2mL
SolutionSubcutaneous5 mg
Injection, solutionSubcutaneous10 mg/2mL
Injection, solutionSubcutaneous20 mg/2mL
SolutionSubcutaneous10 mg
Injection, powder, for solutionSubcutaneous1.3 mg/ml
Injection, powder, for solutionSubcutaneous5 mg/ml
Kit; powder, for solutionSubcutaneous
KitIntramuscular; Subcutaneous
Powder, for solutionIntramuscular; Subcutaneous5 mg
SolutionSubcutaneous5.83 mg
SolutionSubcutaneous8 mg
Powder, for solutionIntramuscular; Subcutaneous
Powder, for solutionSubcutaneous8.8 mg
KitSubcutaneous
Powder, for solutionSubcutaneous
Injection, powder, for solutionSubcutaneous15 mg/1.5ml
Kit
KitSubcutaneous
Prices
Unit descriptionCostUnit
Humatrope 24 mg cartridge1822.9USD cartridge
Norditropin flexpro 15 mg/1.51179.54USD ml
Norditropin 15 mg/1.5ml Solution 1.5ml Cartridge1168.32USD cartridge
Norditropin NordiFlex Pen 15 mg/1.5ml Solution 1 Syringe = 1.5ml1168.32USD pen
Norditropin 15 mg/1.5 ml cartridge1123.38USD ml
Norditropin nordiflx 15 mg/1.51123.38USD ml
Genotropin 12 mg Solution928.36USD each
Humatrope 12 mg cartridge911.45USD cartridge
Nutropin 10 mg vial784.7USD vial
Nutropin aq 20 mg/2ml pen cart759.55USD ml
Nutropin aq nuspin 20 pen cart759.55USD ml
Norditropin NordiFlex Pen 10 mg/1.5ml Solution 1 Syringe = 1.5ml753.86USD pen
Norditropin nordiflex 30 mg/3748.92USD ml
Saizen 8.8 mg Solution Vial626.1USD vial
Saizen Click.Easy 8.8 mg Solution Vial626.1USD vial
Saizen 8.8 mg vial602.02USD vial
Protropin 10 mg Solution Vial549.9USD vial
Humatrope 6 mg cartridge455.72USD cartridge
Genotropin MiniQuick 0.8 mg (7 Cartridges Per Box)433.56USD box
Serostim 8.8 mg vial418.66USD vial
Nutropin 5 mg vial392.35USD vial
Saizen 5 mg Solution Vial391.31USD vial
Genotropin 5.8 mg Cartridge391.21USD cartridge
Norditropin 5 mg/1.5ml Solution 1.5ml Cartridge389.44USD cartridge
Norditropin NordiFlex Pen 5 mg/1.5ml Solution 1 Syringe = 1.5ml389.44USD pen
Saizen 5 mg vial376.26USD vial
Serostim 6 mg vial332.86USD vial
Genotropin MiniQuick 0.6 mg (7 Cartridges Per Box)326.67USD box
Omnitrope 5.8 mg Solution Vial283.38USD vial
Serostim 5 mg vial277.38USD vial
Protropin 5 mg Solution Vial274.95USD vial
Tev-Tropin 5 mg Solution Vial259.45USD vial
Tev-tropin 5 mg vial239.51USD vial
Genotropin MiniQuick 0.4 mg (7 Cartridges Per Box)228.45USD box
Serostim 4 mg vial221.9USD vial
Genotropin MiniQuick 2 mg (7 Cartridges Per Box)154.72USD cartridge
Genotropin miniquick 2 mg150.46USD each
Genotropin miniquick 1.8 mg135.41USD each
Genotropin MiniQuick 1.6 mg (7 Cartridges Per Box)123.78USD cartridge
Genotropin miniquick 1.6 mg120.37USD each
Genotropin MiniQuick 0.2 mg (7 Cartridges Per Box)110.52USD box
Genotropin MiniQuick 1.4 mg (7 Cartridges Per Box)108.78USD cartridge
Genotropin miniquick 1.4 mg105.32USD each
Genotropin MiniQuick 1.2 mg (7 Cartridges Per Box)92.83USD cartridge
Genotropin miniquick 1.2 mg90.28USD each
Genotropin MiniQuick 1 mg (7 Cartridges Per Box)77.36USD cartridge
Genotropin miniquick 1 mg75.23USD each
Genotropin miniquick 0.8 mg60.19USD each
Genotropin miniquick 0.6 mg45.14USD each
Genotropin miniquick 0.4 mg30.09USD each
Genotropin miniquick 0.2 mg15.05USD each
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Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5288703No1994-10-072011-10-07Us
CA2252535No2009-06-232017-04-24Canada
CA1326439No1994-01-252011-01-25Canada
US6152897No1998-11-202018-11-20Us
US5898030No1996-04-272016-04-27Us
US8672898No2002-01-022022-01-02Us
US8684969No2005-10-202025-10-20Us
US9132239No2012-02-012032-02-01Us
US8920383No2006-07-172026-07-17Us
US7686786No2006-08-032026-08-03Us
US6899699No2002-01-022022-01-02Us
US9108002No2006-01-202026-01-20Us
USRE41956Yes2001-07-212021-07-21Us
US6004297Yes1999-07-282019-07-28Us
USRE43834No1999-01-282019-01-28Us
US5849700No1995-12-152015-12-15Us
US5849704No1995-12-152015-12-15Us
US8841252No1997-12-262017-12-26Us
US6235004No1999-01-282019-01-28Us
US9486588No2002-01-022022-01-02Us
US9457154No2007-09-272027-09-27Us
USRE46363No2006-08-032026-08-03Us
US9687611No2007-02-272027-02-27Us

Properties

State
Liquid
Experimental Properties
PropertyValueSource
melting point (°C)76 °C at pH 3.5Gomez-Orellana, I. et al., Protein Sci. 7:1352-1358 (1998)
hydrophobicity-0.411Not Available
isoelectric point5.27Not Available

Taxonomy

Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Binder
General Function
Protein kinase binding
Specific Function
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity).The soluble form (GHBP) acts as a rese...
Gene Name
GHR
Uniprot ID
P10912
Uniprot Name
Growth hormone receptor
Molecular Weight
71498.885 Da
References
  1. Walenkamp MJ, Wit JM: Genetic disorders in the growth hormone - insulin-like growth factor-I axis. Horm Res. 2006;66(5):221-30. [PubMed:16917171]
  2. Wu XY, Xu Z, Chen C, Liu FK, Li JS: [Correlation of growth hormone receptor expression to preoperative radiosensitivity of rectal cancer patients]. Ai Zheng. 2006 Sep;25(9):1162-7. [PubMed:16965663]
  3. Adriani M, Garbi C, Amodio G, Russo I, Giovannini M, Amorosi S, Matrecano E, Cosentini E, Candotti F, Pignata C: Functional interaction of common gamma-chain and growth hormone receptor signaling apparatus. J Immunol. 2006 Nov 15;177(10):6889-95. [PubMed:17082603]
  4. Choi JH, Kim HS, Kim SH, Yang YR, Bae YS, Chang JS, Kwon HM, Ryu SH, Suh PG: Phospholipase Cgamma1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B. Nat Cell Biol. 2006 Dec;8(12):1389-97. Epub 2006 Nov 26. [PubMed:17128263]
  5. Bernstein RM, Leigh SR, Donovan SM, Monaco MH: Hormones and body size evolution in papionin primates. Am J Phys Anthropol. 2007 Feb;132(2):247-60. [PubMed:17133434]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
Kind
Protein
Organism
Human
Pharmacological action
Yes
General Function
Protein homodimerization activity
Specific Function
This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and...
Gene Name
PRLR
Uniprot ID
P16471
Uniprot Name
Prolactin receptor
Molecular Weight
69505.045 Da
References
  1. Keeler C, Jablonski EM, Albert YB, Taylor BD, Myszka DG, Clevenger CV, Hodsdon ME: The kinetics of binding human prolactin, but not growth hormone, to the prolactin receptor vary over a physiologic pH range. Biochemistry. 2007 Mar 6;46(9):2398-410. Epub 2007 Feb 6. [PubMed:17279774]
  2. Ahmed TA, Buzzelli MD, Lang CH, Capen JB, Shumate ML, Navaratnarajah M, Nagarajan M, Cooney RN: Interleukin-6 inhibits growth hormone-mediated gene expression in hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1793-803. Epub 2007 Mar 29. [PubMed:17395896]
  3. Moderscheim TA, Gorba T, Pathipati P, Kokay IC, Grattan DR, Williams CE, Scheepens A: Prolactin is involved in glial responses following a focal injury to the juvenile rat brain. Neuroscience. 2007 Mar 30;145(3):963-73. Epub 2007 Feb 20. [PubMed:17317019]
  4. Cunningham BC, Bass S, Fuh G, Wells JA: Zinc mediation of the binding of human growth hormone to the human prolactin receptor. Science. 1990 Dec 21;250(4988):1709-12. [PubMed:2270485]

Drug created on June 13, 2005 07:24 / Updated on November 19, 2017 20:34