Amino Acids, Acidic

Amino acids with side chains that are negatively charged at physiological pH.
DrugDrug NameDrug Indication
DB00128L-Aspartic AcidThere is no support for the claim that aspartates are exercise performance enhancers, i.e. ergogenic aids.
DB00142Glutamic AcidConsidered to be nature's "Brain food" by improving mental capacities; helps speed the healing of ulcers; gives a "lift" from fatigue; helps control alcoholism, schizophrenia and the craving for sugar.
DB00642PemetrexedUsed in combination with cisplatin for the treatment of malignant pleural mesothelioma in adults whose disease is unresectable or who otherwise are not candidates for potentially curative surgery. Also used as a monotherapy for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) after prior chemotherapy
DB01221KetamineKetamine is indicated as an anesthetic agent for recommended diagnostic and surgical procedures. If skeletal muscle relaxation is needed, it should be combined with a muscle relaxant. If the surgical procedure involves visceral pain, it should be supplemented with an agent that obtunds visceral pain. Ketamine can be used for induction of anesthesia prior other general anesthetic agents and as a supplement of low potency agents.[L1336, FDA label] Reports have indicated a potential use of ketamine as a therapeutic tool for the management of depression when administered in lower doses.[A31873] These reports have increased the interest for ketamine in this area and several clinical trials are launched for this indication.[L1337, A31874]
DB02655D-Aspartic AcidNot Available
DB03088Pidolic AcidThere is currently no clinically approved and/or marketed medicine that relies upon pidolic acid as an active ingredient for any formal therapeutic indication. Although pidolic acid may be sold in a variety of non-prescription, over-the-counter dietary supplement products for cognitive or memory enhancement, there are many studies that suggest that such products or such supplementation do not elicit any kind of cognitive benefit to users [A32981, A32982]. In fact, the general suggestion for any such pidolic acid product is to exercise caution in their recommendation as much more research is necessary [A32981]. Pidolic acid and sodium pidolic acid are, however, used to some extent in skin and hair conditioning agents owing to their humectant characteristics [F53].
DB034252s,4r-4-MethylglutamateNot Available
DB03459Sparfosic acidNot Available
DB03640Beta-Hydroxyaspartic AcidNot Available
DB04418Adenylosuccinic AcidNot Available
DB04498Aspartate SemialdehydeNot Available
DB06775Carglumic acidFor the treatment of acute and chronic hyperammonaemia in patients with N-acetylglutamate synthase (NAGS) deficiency. This enzyme is an important component of the urea cycle to prevent build up of neurotoxic ammonium in the blood.
DB11256Levomefolic acidFor the treatment and prevention of folate deficiency and for use as an antidote against folic acid antagonists. Contained in oral contraceptives to reduce the risk of neural tube defects arising from folic acid deficiency for pregnant women who conceived during use or shortly after the discontinuation of the product. Being studied for use as a treatment for cardiovascular diseases [A19273] and adjunct therapy for patients undergoing antidepressant pharmacotherapy [A19271, A19272].
DB11364PidotimodFor use as immunostimulant therapy for treatment of cell-mediated immunosuppression with respiratory or urinary infections [L929].
DB12224Oxothiazolidinecarboxylic acidNot Available
DB12444TheanineNot Available
DB12514Iofolastat I-123Not Available
DB13359Magnesium aspartateNot Available
DB13809Paclitaxel poliglumexNot Available
DB038103-Methylglutamic acidNot Available
DrugDrug NameTargetType
DB00128L-Aspartic AcidCalcium-binding mitochondrial carrier protein Aralar2target
DB00128L-Aspartic AcidAspartate aminotransferase, cytoplasmictarget
DB00128L-Aspartic AcidAspartoacylasetarget
DB00128L-Aspartic AcidAsparagine synthetase [glutamine-hydrolyzing]target
DB00128L-Aspartic AcidArgininosuccinate synthasetarget
DB00128L-Aspartic AcidAminoacylase-1target
DB00128L-Aspartic AcidAspartate aminotransferase, mitochondrialtarget
DB00128L-Aspartic AcidAspartate--tRNA ligase, cytoplasmictarget
DB00128L-Aspartic AcidCalcium-binding mitochondrial carrier protein Aralar1target
DB00128L-Aspartic AcidAspartyl/asparaginyl beta-hydroxylasetarget
DB00128L-Aspartic AcidMultifunctional protein ADE2target
DB00128L-Aspartic AcidCAD proteintarget
DB00128L-Aspartic AcidAdenylosuccinate synthetase isozyme 2target
DB00128L-Aspartic AcidExcitatory amino acid transporter 3target
DB00128L-Aspartic AcidAspartate aminotransferasetarget
DB00128L-Aspartic AcidArgininosuccinate synthetase, isoform CRA_atarget
DB00128L-Aspartic AcidAspartate--tRNA ligase, mitochondrialtarget
DB00128L-Aspartic AcidIsoaspartyl peptidase/L-asparaginasetarget
DB00128L-Aspartic AcidAdenylosuccinate synthetase isozyme 1target
DB00128L-Aspartic AcidAspartoacylase-2target
DB00128L-Aspartic AcidRibonuclease pancreatictarget
DB00128L-Aspartic AcidLysozyme Ctarget
DB00128L-Aspartic AcidMonocarboxylate transporter 10transporter
DB00142Glutamic AcidGlutamate dehydrogenase 1, mitochondrialtarget
DB00142Glutamic AcidGlutamate receptor ionotropic, kainate 1target
DB00142Glutamic AcidGlutamate receptor 1target
DB00142Glutamic AcidGlutamate--cysteine ligase regulatory subunittarget
DB00142Glutamic AcidGlutamate carboxypeptidase 2target
DB00142Glutamic AcidGlutamate decarboxylase 2target
DB00142Glutamic AcidGlutamate decarboxylase 1target
DB00142Glutamic AcidFormimidoyltransferase-cyclodeaminasetarget
DB00142Glutamic AcidGlutamate receptor 2target
DB00142Glutamic AcidGlutamate receptor 3target
DB00142Glutamic AcidGlutamate receptor 4target
DB00142Glutamic AcidDelta-1-pyrroline-5-carboxylate synthasetarget
DB00142Glutamic AcidGlutamate receptor ionotropic, kainate 2target
DB00142Glutamic AcidGlutamate receptor ionotropic, kainate 3target
DB00142Glutamic AcidMetabotropic glutamate receptor 1target
DB00142Glutamic AcidMetabotropic glutamate receptor 4target
DB00142Glutamic AcidGlutamate receptor ionotropic, kainate 4target
DB00142Glutamic AcidGlutamate receptor ionotropic, kainate 5target
DB00142Glutamic AcidMetabotropic glutamate receptor 7target
DB00142Glutamic AcidMetabotropic glutamate receptor 8target
DB00142Glutamic AcidExcitatory amino acid transporter 5target
DB00142Glutamic Acid5-oxoprolinasetarget
DB00142Glutamic AcidPhosphoribosylformylglycinamidine synthasetarget
DB00142Glutamic AcidBranched-chain-amino-acid aminotransferase, mitochondrialtarget
DB00142Glutamic AcidGlutamate receptor ionotropic, NMDA 2Dtarget
DB00142Glutamic AcidGlutamate receptor ionotropic, delta-2target
DB00142Glutamic AcidGlutamate receptor ionotropic, NMDA 3Btarget
DB00142Glutamic AcidGlutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrialtarget
DB00142Glutamic AcidGlutaminase kidney isoform, mitochondrialtarget
DB00142Glutamic AcidAspartate aminotransferase, mitochondrialtarget
DB00142Glutamic AcidBifunctional glutamate/proline--tRNA ligasetarget
DB00142Glutamic AcidAsparagine synthetase [glutamine-hydrolyzing]target
DB00142Glutamic AcidGlutamine synthetasetarget
DB00142Glutamic AcidAspartate aminotransferase, cytoplasmictarget
DB00142Glutamic AcidTyrosine aminotransferasetarget
DB00142Glutamic AcidAlanine aminotransferase 1target
DB00142Glutamic AcidVitamin K-dependent gamma-carboxylasetarget
DB00142Glutamic AcidExcitatory amino acid transporter 1target
DB00142Glutamic AcidExcitatory amino acid transporter 2target
DB00142Glutamic AcidExcitatory amino acid transporter 3target
DB00142Glutamic AcidGlutamate--cysteine ligase catalytic subunittarget
DB00142Glutamic AcidExcitatory amino acid transporter 4target
DB00142Glutamic AcidGlutamate dehydrogenase 2, mitochondrialtarget
DB00142Glutamic AcidGMP synthase [glutamine-hydrolyzing]target
DB00142Glutamic AcidBranched-chain-amino-acid aminotransferase, cytosolictarget
DB00142Glutamic Acid4-aminobutyrate aminotransferase, mitochondrialtarget
DB00142Glutamic AcidGlutamate receptor ionotropic, NMDA 1target
DB00142Glutamic AcidFolylpolyglutamate synthase, mitochondrialtarget
DB00142Glutamic AcidGlutamyl aminopeptidasetarget
DB00142Glutamic AcidGlutamate receptor ionotropic, NMDA 2Atarget
DB00142Glutamic AcidGlutamate receptor ionotropic, NMDA 2Btarget
DB00142Glutamic AcidGlutamate receptor ionotropic, NMDA 2Ctarget
DB00142Glutamic AcidAspartate aminotransferasetarget
DB00142Glutamic AcidProbable glutamate--tRNA ligase, mitochondrialtarget
DB00142Glutamic AcidLengsintarget
DB00142Glutamic AcidGlutamine-dependent NAD(+) synthetasetarget
DB00142Glutamic AcidKynurenine--oxoglutarate transaminase 3target
DB00142Glutamic AcidN-acetylglutamate synthase, mitochondrialtarget
DB00142Glutamic AcidKynurenine/alpha-aminoadipate aminotransferase, mitochondrialtarget
DB00142Glutamic AcidGlutamate receptor ionotropic, NMDA 3Atarget
DB00142Glutamic AcidAlanine aminotransferase 2target
DB00142Glutamic AcidMitochondrial glutamate carrier 2target
DB00142Glutamic AcidMitochondrial glutamate carrier 1target
DB00142Glutamic AcidAlpha-aminoadipic semialdehyde synthase, mitochondrialtarget
DB00142Glutamic AcidGlutaminase liver isoform, mitochondrialtarget
DB00142Glutamic AcidAspartyl aminopeptidasetarget
DB00142Glutamic AcidGlutamate receptor ionotropic, delta-1target
DB00142Glutamic AcidCystine/glutamate transportertarget
DB00142Glutamic AcidCarboxypeptidase Qtarget
DB00142Glutamic AcidPhosphoserine aminotransferasetarget
DB00142Glutamic AcidMonocarboxylate transporter 10transporter
DB00142Glutamic AcidMonocarboxylate transporter 1transporter
DB00642PemetrexedThymidylate synthasetarget
DB00642PemetrexedDihydrofolate reductasetarget
DB00642PemetrexedTrifunctional purine biosynthetic protein adenosine-3target
DB00642PemetrexedDeoxycytidine kinaseenzyme
DB00642PemetrexedBifunctional purine biosynthesis protein PURHtarget
DB00642PemetrexedEquilibrative nucleoside transporter 1enzyme
DB00642PemetrexedSolute carrier family 22 member 8transporter
DB01221KetamineGlutamate receptor ionotropic, NMDA 3Atarget
DB01221KetamineSubstance-P receptortarget
DB01221KetamineCytochrome P450 2B6enzyme
DB01221KetamineCytochrome P450 2C9enzyme
DB01221KetamineCytochrome P450 3A4enzyme
DB01221KetamineD(2) dopamine receptortarget
DB01221KetamineProstaglandin G/H synthase 1enzyme
DB01221KetamineCytochrome P450 2C8enzyme
DB01221KetamineDelta-type opioid receptortarget
DB01221KetamineSodium-dependent noradrenaline transportertarget
DB01221KetamineKappa-type opioid receptortarget
DB01221KetamineMu-type opioid receptortarget
DB01221KetamineMuscarinic acetylcholine receptortarget
DB01221Ketamine5-hydroxytryptamine receptor 2target
DB01221Ketamine5-hydroxytryptamine receptor 1target
DB01221Ketamine5-hydroxytryptamine receptor 3Atarget
DB01221KetamineAlpha-7 nicotinic cholinergic receptor subunittarget
DB01221KetamineCholinesterasetarget
DB01221KetamineNitric oxide synthase, braintarget
DB02655D-Aspartic AcidThermolysintarget
DB02655D-Aspartic AcidL-asparaginasetarget
DB03088Pidolic AcidAlpha-amylase 2Btarget
DB03088Pidolic AcidAngiogenintarget
DB03088Pidolic AcidChondroitinase-Btarget
DB03088Pidolic AcidAlpha-amylase 1target
DB03088Pidolic AcidVascular endothelial growth factor Atarget
DB03088Pidolic AcidPancreatic alpha-amylasetarget
DB03088Pidolic AcidIg lambda-1 chain C regionstarget
DB03088Pidolic AcidIg lambda chain V-II region MGCtarget
DB03088Pidolic AcidTrefoil factor 2target
DB03088Pidolic AcidCytochrome c2target
DB03088Pidolic AcidDisintegrin and metalloproteinase domain-containing protein 28target
DB03088Pidolic AcidEndo-1,4-beta-xylanasetarget
DB03088Pidolic AcidDissimilatory copper-containing nitrite reductasetarget
DB03088Pidolic AcidKeratin-associated protein 5-2target
DB03088Pidolic AcidOrexintarget
DB03088Pidolic AcidC-C motif chemokine 8target
DB03088Pidolic AcidCytochrome c'target
DB03088Pidolic AcidPancreatic alpha-amylaseenzyme
DB034252s,4r-4-MethylglutamateGlutamate receptor ionotropic, kainate 2target
DB03459Sparfosic acidAspartate carbamoyltransferase catalytic chaintarget
DB03459Sparfosic acidCAD proteintarget
DB03640Beta-Hydroxyaspartic AcidBeta-lactamase TEMtarget
DB04418Adenylosuccinic AcidAdenylosuccinate synthetase isozyme 1target
DB04498Aspartate SemialdehydeAspartate-semialdehyde dehydrogenasetarget
DB06775Carglumic acidCarbamoyl-phosphate synthase [ammonia], mitochondrialtarget
DB11256Levomefolic acidProton-coupled folate transportertransporter
DB11256Levomefolic acidFolate transporter 1transporter
DB11256Levomefolic acidMethionine synthaseenzyme