Dicarboxylic Acids

Acyclic acids that contain two carboxyl groups and have the formula HO2C-R-CO2H, where R may be an aromatic or aliphatic group.
DrugDrug NameDrug Description
DB00139Succinic acidFor nutritional supplementation, also for treating dietary shortage or imbalance
DB00202SuccinylcholineA depolarizing skeletal muscle relaxant used as an adjunct to anesthesia and for skeletal muscle relaxation during intubation, mechanical ventilation, and surgical procedures.
DB00566SuccimerA mercaptodicarboxylic acid heavy metal chelator used in the treatment of heavy metal poisoning.
DB01677Fumaric AcidNot Available
DB02175Malonic acidNot Available
DB03553Glutaric AcidNot Available
DB03589Alpha-Ketomalonic AcidNot Available
DB03902Oxalic AcidA strong dicarboxylic acid occurring in many plants and vegetables. It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. It is not metabolized but excreted...
DB04183Methylmalonic AcidA malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed...
DB04299Maleic AcidNot Available
DB04489Guanidinoethylmercaptosuccinic acidNot Available
DB045943-hydroxyglutaric acidNot Available
DB04734Citraconic acidCitraconic acid is one of the isomeric dicarboxylic acids produced by the distillation of citric acid, or as metabolites by microorganisms, cis-CH3-C(CO2H)=CHCO2H; the trans-isomer is mesaconic acid.
DB05457OSI-7904LInvestigated for use/treatment in gastric cancer.
DB05938EdonerpicInvestigated for use/treatment in alzheimer's disease.
DB06581BevirimatInvestigated for use/treatment in HIV infection.
DB08845Oxogluric acidα-α-Ketoglutarate is not approved for any indication in the world but is an investigational drug in the United States. The potential indications for α-Ketoglutarate are in patients with the metabolic...
DB08908Dimethyl fumarateA medication used to treat patients with the relapsing-remitting form of multiple sclerosis.
DB09026AliskirenA direct renin inhibitor used to manage hypertension.
DB09274ArtesunateFor the treatment of severe malaria caused by Plasmodium falciparum in adults and children
DB09276Sodium aurothiomalateA disease-modifying antirheumatic drug (DMARD) indicated for the symptomatic treatment of arthritis.
DB09459L-tartaric acidTartaric Acid is primarily indicated in conditions like Antiscorbutic, Antiseptic.
DB11209Iron protein succinylateNot Annotated
DB11829RuboxistaurinRuboxistaurin has been investigated for the basic science of Type 2 Diabetes Mellitus and Type 1 Diabetes Mellitus.
DB11913LY-2090314Ly2090314 has been used in trials studying the treatment of Leukemia, Advanced Cancer, and Pancreatic Cancer.
DB12163SarpogrelateSarpogrelate has been investigated for the treatment of Diabetes Mellitus, Diabetic Nephropathy, Coronary Artery Disease, and Renal Insufficiency, Chronic.
DB12751Malic AcidMalic Acid has been used in trials studying the treatment of Xerostomia, Depression, and Hypertension.
DB12934GranotapideGranotapide has been used in trials studying the treatment of Type II Diabetes Mellitus.
DB13286BumadizoneBumadizone has been approved for use in Germany and Austria, it is a drug with anti-inflammatory, antipyretic, and analgesic properties, and was marketed for the treatment of both rheumatoid arthritis...
DB13707Sodium tartrateIt acts as an emulsifier and pH control agent in food products,. In the laboratory, it is used while performing the Karl Fischer equation, which is used to determine the...
DB14219Monomethyl fumarateNot Annotated
DB14508Lithium succinateNot Available
DB04377MeglutolAn antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as...
DB15166AlbuvirtideAlbuvirtide is under investigation in clinical trial NCT03719664 (Albuvirtide and 3BNC117 as Long-Acting Maintenance Therapy in Virologically Suppressed Subjects).
DB031342-Aminopimelic AcidNot Available
DrugDrug NameTargetType
DB00139Succinic acidSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialtarget
DB00139Succinic acidSolute carrier family 13 member 3target
DB00139Succinic acidSolute carrier family 13 member 2target
DB00139Succinic acidSolute carrier family 13 member 1target
DB00139Succinic acidSuccinyl-CoA ligase [GDP-forming] subunit beta, mitochondrialtarget
DB00139Succinic acid17-beta-hydroxysteroid dehydrogenase type 6target
DB00139Succinic acidSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialtarget
DB00139Succinic acidProlyl 4-hydroxylase subunit alpha-2target
DB00139Succinic acidProcollagen-lysine,2-oxoglutarate 5-dioxygenase 3target
DB00139Succinic acidGamma-butyrobetaine dioxygenasetarget
DB00139Succinic acidProlyl 4-hydroxylase subunit alpha-1target
DB00139Succinic acidSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialtarget
DB00139Succinic acidSuccinate-semialdehyde dehydrogenase, mitochondrialtarget
DB00139Succinic acidSuccinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrialtarget
DB00139Succinic acidSuccinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrialtarget
DB00139Succinic acidProcollagen-lysine,2-oxoglutarate 5-dioxygenase 1target
DB00139Succinic acidAspartyl/asparaginyl beta-hydroxylasetarget
DB00139Succinic acidProlyl 3-hydroxylase 1target
DB00139Succinic acidProlyl 3-hydroxylase 2target
DB00139Succinic acidProlyl 3-hydroxylase 3target
DB00139Succinic acidSuccinate dehydrogenase cytochrome b560 subunit, mitochondrialtarget
DB00139Succinic acidSuccinate receptor 1target
DB00139Succinic acidSuccinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrialtarget
DB00139Succinic acidTrimethyllysine dioxygenase, mitochondrialtarget
DB00139Succinic acidSuccinyl-CoA ligase [ADP-forming] subunit beta, mitochondrialtarget
DB00139Succinic acidMitochondrial dicarboxylate carriertarget
DB00139Succinic acidSolute carrier family 22 member 8transporter
DB00202SuccinylcholineMuscarinic acetylcholine receptor M1target
DB00202SuccinylcholineMuscarinic acetylcholine receptor M2target
DB00202SuccinylcholineMuscarinic acetylcholine receptor M3target
DB00202SuccinylcholineAlpha-7 nicotinic cholinergic receptor subunittarget
DB00202SuccinylcholineNeuronal acetylcholine receptor subunit alpha-10target
DB01677Fumaric AcidMalate dehydrogenasetarget
DB01677Fumaric AcidFumarate reductase flavoprotein subunittarget
DB01677Fumaric AcidNAD-dependent malic enzyme, mitochondrialtarget
DB01677Fumaric AcidFumarylacetoacetasetarget
DB01677Fumaric AcidFumarate reductase flavoprotein subunittarget
DB02175Malonic acidAspartate 1-decarboxylasetarget
DB02175Malonic acidProto-oncogene tyrosine-protein kinase Srctarget
DB02175Malonic acidSigma factor SigB regulation protein RsbQtarget
DB02175Malonic acidPutative cytochrome P450target
DB02175Malonic acidU1 small nuclear ribonucleoprotein Atarget
DB02175Malonic acidMalonamidase E2target
DB02175Malonic acidAcetyl transferasetarget
DB03553Glutaric AcidAspartate aminotransferasetarget
DB03553Glutaric AcidBranched-chain-amino-acid aminotransferasetarget
DB03553Glutaric AcidGlutamate decarboxylase alphatarget
DB03553Glutaric AcidSolute carrier family 22 member 6transporter
DB03553Glutaric AcidSolute carrier family 22 member 8transporter
DB03553Glutaric AcidSolute carrier family 22 member 11transporter
DB03553Glutaric AcidSolute carrier family 22 member 7transporter
DB03589Alpha-Ketomalonic AcidNAD-dependent malic enzyme, mitochondrialtarget
DB03902Oxalic AcidProto-oncogene tyrosine-protein kinase Srctarget
DB03902Oxalic AcidSolute carrier organic anion transporter family member 2B1transporter
DB03902Oxalic AcidSolute carrier family 22 member 8transporter
DB04183Methylmalonic AcidMethylmalonyl-CoA carboxyltransferase 12S subunittarget
DB04299Maleic AcidAspartate aminotransferasetarget
DB04299Maleic AcidTrypanothione reductasetarget
DB04299Maleic AcidAspartate aminotransferasetarget
DB04299Maleic AcidAromatic-amino-acid aminotransferasetarget
DB04299Maleic AcidAspartate aminotransferase, cytoplasmictarget
DB04489Guanidinoethylmercaptosuccinic acidCarboxypeptidase Dtarget
DB045943-hydroxyglutaric acidHydroxymethylglutaryl-CoA lyase, mitochondrialtarget
DB04734Citraconic acidFumarate reductase flavoprotein subunittarget
DB05457OSI-7904LThymidylate synthasetarget
DB05938EdonerpicAmyloid beta A4 proteintarget
DB06581BevirimatGag-Pol polyproteintarget
DB08845Oxogluric acidAspartate aminotransferasetarget
DB08908Dimethyl fumarateKelch-like ECH-associated protein 1target
DB08908Dimethyl fumarateTranscription factor p65target
DB09026AliskirenCytochrome P450 3A4enzyme
DB09274ArtesunateMalaria protein EXP-1target
DB09274ArtesunateCytochrome P450 2A6enzyme
DB09274ArtesunateCytochrome P450 3A4enzyme
DB09276Sodium aurothiomalateUDP-glucuronosyltransferase 1-1enzyme
DB09459L-tartaric acidGalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1enzyme
DB09459L-tartaric acidHypoxia-inducible factor 1-alpha inhibitorenzyme
DB12163Sarpogrelate5-hydroxytryptamine receptor 2Ctarget
DB12163Sarpogrelate5-hydroxytryptamine receptor 2Atarget
DB14508Lithium succinateInositol monophosphatase 2target
DB14508Lithium succinateInositol monophosphatase 1target
DB14508Lithium succinateGlycogen synthase kinase-3 betatarget
DB14508Lithium succinateGlutamate receptor 3target
DB04377Meglutol3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB031342-Aminopimelic Acid2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferasetarget