Sodium tartrate

Identification

Name
Sodium tartrate
Accession Number
DB13707
Type
Small Molecule
Groups
Approved
Description

Sodium tartrate is a disodium salt of l-( + )-tartaric acid that is identified by transparent, colorless, and odorless crystals. It is obtained as a byproduct of wine manufacturing. Sodium tartrate is generally recognized as safe (GRAS) as a direct human food ingredient. It acts as an emulsifier and pH control agent in food products [1].

This compound is commonly used as an emulsifier in cheese/cheese spread products and is not to exceed 4% concentration, according to Health Canada regulations [5].

Structure
Thumb
Synonyms
  • Bisodium tartrate
  • Disodium L-(+)-tartrate
  • disodium tartrate
  • sodium L-tartrate
  • Tartaric acid, disodium salt
External IDs
E-335(II) / INS NO.335(II) / INS-335(II)
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Limonade RodecaLiquid5.6 gOralRodeca Inc., Division Of Technilab Inc.1962-12-312003-09-22Canada
Categories
UNII
QTO9JB4MDD
CAS number
868-18-8
Weight
Average: 194.05
Monoisotopic: 193.98032641
Chemical Formula
C4H4Na2O6
InChI Key
HELHAJAZNSDZJO-OLXYHTOASA-L
InChI
InChI=1S/C4H6O6.2Na/c5-1(3(7)8)2(6)4(9)10;;/h1-2,5-6H,(H,7,8)(H,9,10);;/q;2*+1/p-2/t1-,2-;;/m1../s1
IUPAC Name
disodium (2R,3R)-2,3-dihydroxybutanedioate
SMILES
[Na+].[Na+].O[C@H]([C@@H](O)C([O-])=O)C([O-])=O

Pharmacology

Indication

It acts as an emulsifier and pH control agent in food products [1], [9]. In the laboratory, it is used while performing the Karl Fischer equation, which is used to determine the water content of various substances [10], [1].

Pharmacodynamics
Not Available
Mechanism of action

Sodium tartrate is a white, crystalline powder, used as an emulsifier and a binding agent. It can be used in jellies, cheeses, sausage casings and any foods which contain fats or oils [8].

Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity

Abdominal cramps, nausea, and vomiting [2].

Oral LD50 in rats is 4360 mg kg-1 [3].

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Sodium tartrate.
AclidiniumThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Aclidinium.
AgmatineThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Agmatine.
AlcuroniumThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Alcuronium.
AlfentanilThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Alfentanil.
AlmasilateThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Almasilate.
AloglutamolThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Aloglutamol.
AlphacetylmethadolThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Alphacetylmethadol.
AlphaprodineThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Alphaprodine.
AluminiumThe therapeutic efficacy of Sodium tartrate can be decreased when used in combination with Aluminium.
Food Interactions
Not Available

References

General References
  1. Sodium Tartrate, PubChem [Link]
  2. Sodium Tartrate Monograph [Link]
  3. Sodium tartrate, chemspider [Link]
  4. Sodium Tartrate Overiew, Science Direct [Link]
  5. List of Permitted Emulsifying, Gelling, Stabilizing or Thickening Agents (Lists of Permitted Food Additives) [Link]
  6. The pharmacology of sodium tartrate [Link]
  7. Sodium tartrate [Link]
  8. Sodium Tartrate, FCC [Link]
  9. Tartrates [Link]
  10. KARL FISCHER ELECTROMETRIC TITRATION METHOD FOR DETERMINATION OF WATER CONTENT [File]
External Links
PubChem Compound
162637
PubChem Substance
347829311
ChemSpider
142788
ChEBI
63017
ChEMBL
CHEMBL2107781
Wikipedia
Sodium_tartrate
ATC Codes
A06AD21 — Sodium tartrate
MSDS
Download (47.1 KB)

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
LiquidOral5.6 g
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)120MSDS
water solubilitySoluble in cold waterMSDS
Predicted Properties
PropertyValueSource
Water Solubility779.0 mg/mLALOGPS
logP-1.9ALOGPS
logP-1.8ChemAxon
logS0.6ALOGPS
pKa (Strongest Acidic)2.72ChemAxon
pKa (Strongest Basic)-4.3ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area120.72 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity47.89 m3·mol-1ChemAxon
Polarizability10.83 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as beta hydroxy acids and derivatives. These are compounds containing a carboxylic acid substituted with a hydroxyl group on the C3 carbon atom.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Hydroxy acids and derivatives
Sub Class
Beta hydroxy acids and derivatives
Direct Parent
Beta hydroxy acids and derivatives
Alternative Parents
Short-chain hydroxy acids and derivatives / Monosaccharides / Fatty acids and conjugates / Dicarboxylic acids and derivatives / Secondary alcohols / Carboxylic acid salts / 1,2-diols / Carboxylic acids / Organic sodium salts / Organic oxides
show 2 more
Substituents
Beta-hydroxy acid / Short-chain hydroxy acid / Fatty acid / Dicarboxylic acid or derivatives / Monosaccharide / 1,2-diol / Carboxylic acid salt / Secondary alcohol / Carboxylic acid derivative / Organic alkali metal salt
show 10 more
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
organic sodium salt (CHEBI:63017)

Drug created on June 23, 2017 14:47 / Updated on November 02, 2018 07:44