Parasympatholytics

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS.
DrugDrug NameDrug Description
DB00209TrospiumAn antimuscarinic agent used to treat the symptoms of overactive bladder (OAB).
DB00219OxyphenoniumFor the treatment of visceral spasms
DB00424HyoscyamineFor treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Also used to treat certain heart conditions, to control the symptoms of Parkinson's disease...
DB00572AtropineA muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs.
DB00771ClidiniumA synthetic anticholinergic used to treat peptic ulcer disease, colicky abdominal pain, diverticulitis, and IBS.
DB00804DicyclomineAn antimuscarinic agent used to treat IBS.
DB00810BiperidenA muscarinic receptor antagonist used to treat parkinsonism and control extrapyramidal side effects of neuroleptic drugs.
DB00979CyclopentolateAn anticholinergic used to cause mydriasis and cycloplegia for diagnostic testing.
DB01062OxybutyninAn antimuscarinic agent that reduces detrusor muscle activity, relaxing the bladder and preventing the urge to void.
DB01148FlavoxateA muscarinic antagonist and spasmolytic used for the symptomatic relief of conditions associated with lack of muscle control in the bladder, such as dysuria, urgency, and nocturia.
DB01173OrphenadrineA muscarinic antagonist used as an adjunct for the symptomatic relief of musculoskeletal pain and discomfort.
DB01409TiotropiumA long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD).
DB01616AlverineUsed to relieve cramps or spasms of the stomach and intestines. It is also useful in treating irritable bowel syndrome (IBS) and similar conditions. It can also be used to...
DB02020AlrestatinNot Available
DB06751DrotaverineUsed in the treatment of functional bowel disorders and alleviating pain in renal colic.
DB08992EperisoneEperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression...
DB08997DexetimideA muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide.
DB09023BenactyzineBenactyzine is an anticholinergic drug used as an antidepressant in the treatment of depression and associated anxiety. Benactyzine is no longer widely used in medicine, although it is still a...
DB09089TrimebutineA spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery.
DB09090PinaveriumA spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract.
DB09271CimetropiumCimetropium is a semi-synthetic belladonna alkaloid and derivative of scopolamine. It is a potent antimuscarinic and an effective antispasmodic drug. It is also endowed of a direct myolitic action which...
DB09300ButylscopolamineAn antispasmodic and anticholinergic agent used for the symptomatic treatment of abdominal cramping and pain.
DB11181HomatropineAn anticholinergic agent used to dilate the pupil, treat inflammation of the uveal tract, and suppress a cough.
DB11198Peppermint oilAn ingredient used in a variety of natural health products and is not an approved medication.
DB11315MethscopolamineMethscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The...
DB11785AnisodamineAnisodamine has been investigated for the treatment of Intestinal Diseases.
DB12086OxitropiumOxitropium has been investigated for the treatment of Pulmonary Disease, Chronic Obstructive.
DB12251MoxaverineMoxaverine has been investigated for the treatment of Retina, Ocular Physiology, and Regional Blood Flow.
DB12278PropiverineAn antimuscarinic agent used to treat urinary incontinence or increased urinary frequency or urgency.
DB12554MebeverineMebeverine has been investigated for the treatment of Irritable Bowel Syndrome and Post-cholecystectomy Gastrointestinal Spasms.
DB13042FenoverineFenoverine has been used in trials studying the treatment of Irritable Bowel Syndrome.
DB13091TiropramideTiropramide is under investigation in clinical trial NCT01629212 (Comparison of the Efficacy and Safety of Tiropramide and Octylonium in the Treatment of Irritable Bowel Syndrome).
DB13500OtiloniumNot Annotated
DB13505EmeproniumNot Annotated
DB13581RociverineNot Annotated
DB13718HydroquinineNot Annotated
DB13725TerodilineNot Annotated
DB13738CamylofinNot Annotated
DB13833MethylatropineNot Annotated
DB13720DiphemanilUsed in the treatment of peptic ulcer, gastric hyperacidity, and hypermotility in gastritis and pylorospasm, and in the treatment of hyperhidrosis (excessive perspiration).
DB15300HydroquinidineHydroquinidine is under investigation in clinical trial NCT00927732 (Hydroquinidine Versus Placebo in Patients With Brugada Syndrome).
DrugDrug NameTargetType
DB00209TrospiumMuscarinic acetylcholine receptor M1target
DB00209TrospiumCytochrome P450 2D6enzyme
DB00219OxyphenoniumMuscarinic acetylcholine receptor M1target
DB00424HyoscyamineMuscarinic acetylcholine receptor M1target
DB00424HyoscyamineMuscarinic acetylcholine receptor M2target
DB00424HyoscyamineMuscarinic acetylcholine receptor M3target
DB00424HyoscyamineMuscarinic acetylcholine receptor M4target
DB00572AtropineMuscarinic acetylcholine receptor M2target
DB00572AtropineMuscarinic acetylcholine receptor M1target
DB00572AtropineMuscarinic acetylcholine receptor M4target
DB00572AtropineMuscarinic acetylcholine receptor M5target
DB00572AtropineMuscarinic acetylcholine receptor M3target
DB00572AtropineGlycine receptor subunit alpha-1target
DB00572AtropineNeuronal acetylcholine receptor subunit alpha-4target
DB00572AtropineNeuronal acetylcholine receptor subunit beta-2target
DB00572AtropineBile salt export pumptransporter
DB00771ClidiniumMuscarinic acetylcholine receptor M1target
DB00804DicyclomineMuscarinic acetylcholine receptor M1target
DB00804DicyclomineMuscarinic acetylcholine receptor M2target
DB00810BiperidenNeuronal acetylcholine receptor subunit alpha-2target
DB00810BiperidenMuscarinic acetylcholine receptor M1target
DB00810BiperidenCytochrome P450 2D6enzyme
DB00979CyclopentolateMuscarinic acetylcholine receptor M1target
DB00979CyclopentolateCholinesteraseenzyme
DB01062OxybutyninMuscarinic acetylcholine receptor M1target
DB01062OxybutyninMuscarinic acetylcholine receptor M2target
DB01062OxybutyninMuscarinic acetylcholine receptor M3target
DB01062OxybutyninCytochrome P450 3A4enzyme
DB01062OxybutyninCytochrome P450 2C8enzyme
DB01062OxybutyninCytochrome P450 2D6enzyme
DB01062OxybutyninCytochrome P450 3A5enzyme
DB01062OxybutyninAlpha-1-acid glycoprotein 1carrier
DB01062OxybutyninSerum albumincarrier
DB01148FlavoxateMuscarinic acetylcholine receptor M1target
DB01148FlavoxateMuscarinic acetylcholine receptor M2target
DB01173OrphenadrineGlutamate receptor ionotropic, NMDA 1target
DB01173OrphenadrineGlutamate receptor ionotropic, NMDA 2Dtarget
DB01173OrphenadrineGlutamate receptor ionotropic, NMDA 3Btarget
DB01173OrphenadrineGlutamate receptor ionotropic, NMDA 3Atarget
DB01173OrphenadrineHistamine H1 receptortarget
DB01173OrphenadrineCytochrome P450 2B6enzyme
DB01173OrphenadrineCytochrome P450 2E1enzyme
DB01173OrphenadrineCytochrome P450 3A4enzyme
DB01173OrphenadrineSodium-dependent noradrenaline transportertarget
DB01173OrphenadrineSodium channel protein type 10 subunit alphatarget
DB01173OrphenadrineCytochrome P450 1A2enzyme
DB01173OrphenadrineCytochrome P450 2D6enzyme
DB01409TiotropiumMuscarinic acetylcholine receptor M3target
DB01409TiotropiumCytochrome P450 2D6enzyme
DB01409TiotropiumCytochrome P450 3A4enzyme
DB01409TiotropiumMuscarinic acetylcholine receptor M1target
DB01409TiotropiumMuscarinic acetylcholine receptor M2target
DB01409TiotropiumSolute carrier family 22 member 5transporter
DB01409TiotropiumSolute carrier family 22 member 4transporter
DB01409TiotropiumMuscarinic acetylcholine receptor M4target
DB01409TiotropiumMuscarinic acetylcholine receptor M5target
DB01616Alverine5-hydroxytryptamine receptor 1Atarget
DB02020AlrestatinAldose reductasetarget
DB06751DrotaverinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB06751DrotaverineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB08992EperisoneCytochrome P450 3A4enzyme
DB09089TrimebutineMu-type opioid receptortarget
DB09089TrimebutineVoltage-dependent L-type calcium channeltarget
DB09089TrimebutineCalcium-activated potassium channeltarget
DB09089TrimebutineVoltage-dependent T-type calcium channeltarget
DB09089TrimebutineMuscarinic acetylcholine receptor M1target
DB09089TrimebutineMuscarinic acetylcholine receptor M2target
DB09089TrimebutineMuscarinic acetylcholine receptor M3target
DB09089TrimebutineMuscarinic acetylcholine receptor M4target
DB09089TrimebutineCytochrome P450 3A4enzyme
DB09090PinaveriumVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB09090PinaveriumCytochrome P450 3A4enzyme
DB09300ButylscopolamineMuscarinic acetylcholine receptor M3target
DB09300ButylscopolamineMuscarinic acetylcholine receptor M2target
DB11181HomatropineLiver carboxylesterase 1enzyme
DB11181HomatropineMuscarinic acetylcholine receptor M1target
DB11181HomatropineMuscarinic acetylcholine receptor M2target
DB11181HomatropineMuscarinic acetylcholine receptor M3target
DB11181HomatropineMuscarinic acetylcholine receptor M4target
DB11181HomatropineMuscarinic acetylcholine receptor M5target
DB11198Peppermint oilCytochrome P450 1A2enzyme
DB11198Peppermint oilCytochrome P450 3A4enzyme
DB11785AnisodamineCytochrome P450 2D6enzyme
DB12278PropiverineMuscarinic acetylcholine receptor M1target
DB12278PropiverineMuscarinic acetylcholine receptor M2target
DB12278PropiverineMuscarinic acetylcholine receptor M3target
DB12278PropiverineMuscarinic acetylcholine receptor M4target
DB12278PropiverineMuscarinic acetylcholine receptor M5target
DB12278PropiverineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB12278PropiverineAlpha-1A adrenergic receptortarget
DB12278PropiverineCytochrome P450 3A4enzyme
DB12278PropiverineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB12278PropiverineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB13500OtiloniumCytochrome P450 3A4enzyme
DB13581RociverineMuscarinic acetylcholine receptor M1target
DB13581RociverineMuscarinic acetylcholine receptor M2target
DB13581RociverineMuscarinic acetylcholine receptor M3target
DB13581RociverineMuscarinic acetylcholine receptor M4target
DB13581RociverineMuscarinic acetylcholine receptor M5target
DB13725TerodilineCytochrome P450 3A4enzyme
DB13720DiphemanilMuscarinic acetylcholine receptor M3target