Isoquinolines

Name
Isoquinolines
Accession Number
DBCAT000551
Description

A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)

Drugs
DrugDrug Description
NelfinavirA viral protease inhibitor used in the treatment of HIV infection.
Metocurine iodideFor use as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy.
CisatracuriumA skeletal muscle relaxant used to facilitate tracheal intubation, muscle relaxation in surgery, or mechanical ventilation.
MoexiprilAn angiotensin converting enzyme inhibitor prodrug used to treat hypertension.
ApomorphineA morphine derivative D2 dopamine agonist used to treat hypomobile "off" episodes of advanced Parkinson's disease.
Atracurium besylateA non-depolarizing neuromuscular blocker used to facilitate endotracheal intubation and relax skeletal muscles during surgery.
QuinaprilAn ACE inhibitor prodrug used to treat hypertension, congestive heart failure, and slow rate of progression of renal disease.
PraziquantelAn anthelmintic medication used to treat a number of parasitic worm infections such as schistosomiasis.
PapaverineAn alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms".
TubocurarineA neuromuscular blocker used for the diagnosis of and facilitation of intubation after induction of anesthesia during surgical procedures.
SaquinavirAn HIV protease inhibitor used in combination with other antiretroviral agents for the treatment of HIV-1 with advanced immunodeficiency.
MetocurineMetocurine is a muscle relaxant.
SolifenacinA muscarinic antagonist with antispasmodic properties used to treat urge urinary incontinence, urgency, and urinary frequency associated with an overactive bladder.
BerberineAn alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal...
HydroxyfasudilNot Available
NomifensineNomifensine, formerly marketed as Merital capsules, was associated with an increased incidence of hemolytic anemia. The approved application holder removed Merital capsules from the market on January 23, 1986. FDA...
DebrisoquineFor the treatment of moderate and severe hypertension, either alone or as an adjunct, and for the treatment of renal hypertension.
ElacridarFor the treatment of solid tumors.
AmonafideInvestigated for use/treatment in breast cancer, ovarian cancer, and prostate cancer.
TrabectedinAn alkylating agent approved for the treatment of unresectable or metastatic soft tissue sarcoma (liposarcoma or leiomyosarcoma).
NoscapineInvestigated for use/treatment in lymphoma (non-hodgkin's), leukemia (lymphoid), cancer/tumors (unspecified), and multiple myeloma.
DrotaverineUsed in the treatment of functional bowel disorders and alleviating pain in renal colic.
S-23An androgen receptor modulator.
5-(2-methylpiperazine-1-sulfonyl)isoquinolineNot Available
7,8-Dichloro-1,2,3,4-tetrahydroisoquinolinePotent reversible inhibitor of phenylethanolamine N-methyltransferase.
BicucullineBicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and...
TetrahydropalmatineTetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity).
MoxaverineMoxaverine has been investigated for the treatment of Retina, Ocular Physiology, and Regional Blood Flow.
ZalypsisZalypsis has been used in trials studying the treatment of Lymphoma, Solid Tumors, Ewing's Sarcoma, Endometrial Cancer, and Uterine Cervical Cancer, among others.
HigenamineHigenamine is under investigation in clinical trial NCT01451229 (Pharmacokinetics and Pharmacodynamics of Higenamine in Chinese Healthy Subjects).
AtracuriumNot Annotated
EmetineNot Annotated
AlcuroniumA non-depolarizing skeletal muscle relaxant similar to tubocurarine. It is used as an anesthesia adjuvant.
TretoquinolNot Annotated
DehydroemetineNot Annotated
TetrandrineNot Annotated
MoexiprilatThe active metabolite of the prodrug Moexipril.
QuinaprilatThe active metabolite of the prodrug quinapril.
FasudilFasudil has been investigated in Carotid Stenosis.
PalonosetronA serotonin antagonist used in the prophylaxis or management of vomiting that results from emetogenic chemotherapy, and for the management of postoperative nausea and vomiting.
MivacuriumA short-acting non-depolarizing neuromuscular blocking agent used to induce anesthesia during intubation and promote skeletal muscle relaxation during surgery or mechanical ventilation.
Drugs & Drug Targets
DrugTargetType
NelfinavirHIV-1 proteasetarget
NelfinavirCytochrome P450 2C19enzyme
NelfinavirCytochrome P450 3A4enzyme
NelfinavirCytochrome P450 2B6enzyme
NelfinavirCytochrome P450 3A5enzyme
NelfinavirCytochrome P450 3A7enzyme
NelfinavirP-glycoprotein 1transporter
NelfinavirSolute carrier family 22 member 1transporter
NelfinavirSolute carrier organic anion transporter family member 1A2transporter
NelfinavirATP-binding cassette sub-family G member 2transporter
NelfinavirSolute carrier organic anion transporter family member 1B1transporter
NelfinavirCytochrome P450 2D6enzyme
NelfinavirSerum albumincarrier
NelfinavirUDP-glucuronosyltransferase 1-1enzyme
NelfinavirSolute carrier organic anion transporter family member 1B3transporter
NelfinavirSolute carrier organic anion transporter family member 2B1transporter
NelfinavirBile salt export pumptransporter
NelfinavirCytochrome P450 2C9enzyme
Metocurine iodideNeuronal acetylcholine receptor subunit alpha-2target
CisatracuriumNeuronal acetylcholine receptor subunit alpha-2target
MoexiprilAngiotensin-converting enzymetarget
MoexiprilSolute carrier family 15 member 1transporter
MoexiprilSolute carrier family 15 member 2transporter
ApomorphineDopamine D2 receptortarget
ApomorphineDopamine D1 receptortarget
ApomorphineDopamine D4 receptortarget
ApomorphineDopamine D3 receptortarget
ApomorphineDopamine D5 receptortarget
ApomorphineAlpha-2C adrenergic receptortarget
ApomorphineAlpha-2B adrenergic receptortarget
Apomorphine5-hydroxytryptamine receptor 2Ctarget
Apomorphine5-hydroxytryptamine receptor 1Atarget
Apomorphine5-hydroxytryptamine receptor 2Atarget
Apomorphine5-hydroxytryptamine receptor 2Btarget
ApomorphineAlpha-2A adrenergic receptortarget
Apomorphine5-hydroxytryptamine receptor 1Dtarget
Apomorphine5-hydroxytryptamine receptor 1Btarget
ApomorphineCatechol O-methyltransferaseenzyme
ApomorphineSulfotransferase 1A1enzyme
ApomorphineSulfotransferase 1A2enzyme
ApomorphineSulfotransferase 1A3/1A4enzyme
ApomorphineEstrogen sulfotransferaseenzyme
ApomorphineSulfotransferase family cytosolic 1B member 1enzyme
ApomorphineCytochrome P450 2B6enzyme
ApomorphineCytochrome P450 2C8enzyme
ApomorphineCytochrome P450 3A4enzyme
ApomorphineCytochrome P450 3A5enzyme
ApomorphineUDP-glucuronosyltransferases (UGTs)enzyme
ApomorphineSerum albumincarrier
ApomorphineSynaptic vesicular amine transportertransporter
Atracurium besylateNeuronal acetylcholine receptor subunit alpha-2target
QuinaprilAngiotensin-converting enzymetarget
QuinaprilSolute carrier family 15 member 1transporter
QuinaprilSolute carrier family 15 member 2transporter
QuinaprilSolute carrier family 22 member 8transporter
QuinaprilLiver carboxylesterase 1enzyme
QuinaprilSerum albumincarrier
PraziquantelSchistosome calcium ion (Ca2+) channelstarget
PraziquantelCytochrome P450 3A4enzyme
PraziquantelCytochrome P450 1A2enzyme
PraziquantelCytochrome P450 2C19enzyme
PraziquantelCytochrome P450 3A43enzyme
PraziquantelCytochrome P450 3A5enzyme
PraziquantelCytochrome P450 3A7enzyme
PapaverinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
PapaverinecAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Atarget
TubocurarineNeuronal acetylcholine receptor subunit alpha-2target
TubocurarineAcetylcholinesterasetarget
Tubocurarine5-hydroxytryptamine receptor 3Atarget
TubocurarineSolute carrier family 22 member 1transporter
TubocurarineSolute carrier family 22 member 2transporter
TubocurarineNeuronal acetylcholine receptor subunit alpha-7target
TubocurarineCholinesteraseenzyme
SaquinavirHuman immunodeficiency virus type 1 proteasetarget
SaquinavirCytochrome P450 3A4enzyme
SaquinavirCytochrome P450 3A5enzyme
SaquinavirAlpha-1-acid glycoprotein 1carrier
SaquinavirSerum albumincarrier
SaquinavirCytochrome P450 3A7enzyme
SaquinavirP-glycoprotein 1transporter
SaquinavirSolute carrier family 22 member 1transporter
SaquinavirSolute carrier organic anion transporter family member 1A2transporter
SaquinavirATP-binding cassette sub-family G member 2transporter
SaquinavirSolute carrier organic anion transporter family member 1B1transporter
SaquinavirMultidrug resistance-associated protein 1transporter
SaquinavirCanalicular multispecific organic anion transporter 1transporter
SaquinavirCytochrome P450 2C8enzyme
SaquinavirCytochrome P450 2D6enzyme
SaquinavirSolute carrier organic anion transporter family member 2B1transporter
SaquinavirBile salt export pumptransporter
MetocurineNeuronal acetylcholine receptor subunit alpha-2target
MetocurineMuscarinic acetylcholine receptor M2target
SolifenacinMuscarinic acetylcholine receptor M3target
SolifenacinMuscarinic acetylcholine receptor M1target
SolifenacinCytochrome P450 3A4enzyme
SolifenacinMuscarinic acetylcholine receptor M2target
SolifenacinMuscarinic acetylcholine receptor M4target
SolifenacinMuscarinic acetylcholine receptor M5target
Solifenacinalpha1-acid glycoproteincarrier
SolifenacinCytochrome P450 1A1enzyme
SolifenacinCytochrome P450 2D6enzyme
BerberineHTH-type transcriptional regulator QacRtarget
BerberineBaculoviral IAP repeat-containing protein 5target
HydroxyfasudilRho-associated protein kinase 1target
HydroxyfasudilcAMP-dependent protein kinase catalytic subunit alphatarget
HydroxyfasudilcAMP-dependent protein kinase inhibitor alphatarget
NomifensineSodium-dependent noradrenaline transportertarget
NomifensineSodium-dependent dopamine transportertarget
NomifensineAlpha-1-acid glycoprotein 1carrier
NomifensineAmine oxidase [flavin-containing] Btarget
NomifensineAmine oxidase [flavin-containing] Atarget
NomifensineMyeloperoxidasetarget
NomifensineSodium-dependent serotonin transportertarget
NomifensineSynaptic vesicular amine transportertarget
DebrisoquineSodium-dependent noradrenaline transportertarget
DebrisoquineCytochrome P450 2D6enzyme
DebrisoquineP-glycoprotein 1transporter
DebrisoquineCytochrome P450 1A1enzyme
ElacridarP-glycoprotein 1target
ElacridarATP-binding cassette sub-family G member 2transporter
ElacridarP-glycoprotein 1transporter
AmonafideDNA topoisomerase 2-alphatarget
AmonafideDNA topoisomerase 2-betatarget
TrabectedinCytochrome P450 3A4enzyme
TrabectedinCytochrome P450 2C9enzyme
TrabectedinCytochrome P450 2D6enzyme
TrabectedinCytochrome P450 2E1enzyme
TrabectedinCytochrome P450 2C19enzyme
TrabectedinDNAtarget
TrabectedinProstaglandin G/H synthase 1enzyme
NoscapineSigma non-opioid intracellular receptor 1target
NoscapineCytochrome P450 2C9enzyme
NoscapineCytochrome P450 3A4enzyme
DrotaverinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DrotaverineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
S-23Androgen receptortarget
5-(2-methylpiperazine-1-sulfonyl)isoquinolinecAMP-dependent protein kinase catalytic subunit alphatarget
5-(2-methylpiperazine-1-sulfonyl)isoquinolinecAMP-dependent protein kinase inhibitor alphatarget
7,8-Dichloro-1,2,3,4-tetrahydroisoquinolinePhenylethanolamine N-methyltransferasetarget
TetrahydropalmatineDopamine D1 receptortarget
TetrahydropalmatineDopamine D2 receptortarget
TetrahydropalmatineCytochrome P450 3A4enzyme
TetrandrineP-glycoprotein 1target
TetrandrineCytochrome P450 3A4enzyme
TetrandrineP-glycoprotein 1transporter
FasudilcAMP-dependent protein kinase inhibitor alphatarget
FasudilcAMP-dependent protein kinase catalytic subunit alphatarget
FasudilRho-associated protein kinase 1target
FasudilRho-associated protein kinase 2target
Palonosetron5-hydroxytryptamine receptor 3Atarget
PalonosetronCytochrome P450 2D6enzyme
PalonosetronCytochrome P450 3A4enzyme
PalonosetronCytochrome P450 1A2enzyme
MivacuriumNeuronal acetylcholine receptor subunit alpha-2target
MivacuriumMuscarinic acetylcholine receptor M2target
MivacuriumMuscarinic acetylcholine receptor M3target
MivacuriumCholinesterasetarget