Isoquinolines

A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)
DrugDrug NameDrug Indication
DB00220NelfinavirUsed in combination with other antiviral drugs in the treatment of HIV in both adults and children.
DB00416Metocurine IodideFor use as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy.
DB00565CisatracuriumFor inpatients and outpatients as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation in the ICU.
DB00691MoexiprilFor the treatment of hypertension.
DB00714ApomorphineFor the acute, intermittent treatment of hypomobility, off episodes (end-of-dose wearing off and unpredictable on/off episodes) associated with advanced Parkinson's disease.
DB00732Atracurium besylateFor use, as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
DB00881QuinaprilFor the treatment of hypertension and as adjunct therapy in the treatment of congestive heart failure. May also be used to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
DB01058PraziquantelFor the treatment of infections due to all species of schistosoma.
DB01113PapaverineFor the treatment of impotence and vasospasms.
DB01199TubocurarineUsed as a diagnosis agent for myasthenia gravis, and also to facilitate the intubation after induction of anesthesia in surgical procedure
DB01232SaquinavirFor the treatment of HIV-1 with advanced immunodeficiency together with antiretroviral nucleoside analogues.
DB01336MetocurineMetocurine is a muscle relaxant.
DB01591SolifenacinSolifenacin tablets are indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency.[L7511]
DB04115BerberineNot Available
DB04707HydroxyfasudilNot Available
DB04821NomifensineNot Available
DB04840DebrisoquineFor the treatment of moderate and severe hypertension, either alone or as an adjunct, and for the treatment of renal hypertension.
DB04881ElacridarFor the treatment of solid tumors.
DB05022AmonafideInvestigated for use/treatment in breast cancer, ovarian cancer, and prostate cancer.
DB05109TrabectedinIndicated for treatment of advanced soft tissue sarcoma in patients refractory to or unsuitable to receive anthracycline or ifosfamide chemotherapy in Europe, Russia and South Korea. Approved for orphan drug status by the U.S. FDA for treatment of soft tissue sarcomas and ovarian cancer. Investigated for use/treatment in cancer/tumors (unspecified), gastric cancer, ovarian cancer, pediatric indications, sarcoma, and solid tumors.
DB06174NoscapineInvestigated for use/treatment in lymphoma (non-hodgkin's), leukemia (lymphoid), cancer/tumors (unspecified), and multiple myeloma.
DB06751DrotaverineUsed in the treatment of functional bowel disorders and alleviating pain in renal colic.
DB07419S-23Not Available
DB079965-(2-methylpiperazine-1-sulfonyl)isoquinolineNot Available
DB085507,8-Dichloro-1,2,3,4-tetrahydroisoquinolineNot Available
DB11562BicucullineNot Available
DB12093TetrahydropalmatineNot Available
DB12251MoxaverineNot Available
DB12454ZalypsisNot Available
DB12779HigenamineNot Available
DB13295AtracuriumNot Available
DB13393EmetineNot Available
DB13648AlcuroniumNot Available
DB13692TretoquinolNot Available
DB13865DehydroemetineNot Available
DB14066TetrandrineNot Available
DB14210MoexiprilatNot Available
DB14217QuinaprilatNot Available
DB08162FasudilNot Available
DB00377PalonosetronFor the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy, as well as prevention of acute nausea and vomiting associated with highly emetogenic cancer chemotherapy. Also used for the prevention of postoperative nausea and vomiting for up to 24 hours post operation.
DB01226MivacuriumFor inpatients and outpatients, as an adjunct to general anesthesia, to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
DrugDrug NameTargetType
DB00220NelfinavirHIV-1 proteasetarget
DB00220NelfinavirCytochrome P450 2C19enzyme
DB00220NelfinavirCytochrome P450 3A4enzyme
DB00220NelfinavirCytochrome P450 2B6enzyme
DB00220NelfinavirCytochrome P450 3A5enzyme
DB00220NelfinavirCytochrome P450 3A7enzyme
DB00220NelfinavirMultidrug resistance protein 1transporter
DB00220NelfinavirSolute carrier family 22 member 1transporter
DB00220NelfinavirSolute carrier organic anion transporter family member 1A2transporter
DB00220NelfinavirATP-binding cassette sub-family G member 2transporter
DB00220NelfinavirSolute carrier organic anion transporter family member 1B1transporter
DB00220NelfinavirCytochrome P450 2D6enzyme
DB00220NelfinavirSerum albumincarrier
DB00220NelfinavirUDP-glucuronosyltransferase 1-1enzyme
DB00220NelfinavirSolute carrier organic anion transporter family member 1B3transporter
DB00220NelfinavirSolute carrier organic anion transporter family member 2B1transporter
DB00220NelfinavirBile salt export pumptransporter
DB00220NelfinavirCytochrome P450 2C9enzyme
DB00416Metocurine IodideNeuronal acetylcholine receptor subunit alpha-2target
DB00565CisatracuriumNeuronal acetylcholine receptor subunit alpha-2target
DB00691MoexiprilAngiotensin-converting enzymetarget
DB00691MoexiprilSolute carrier family 15 member 1transporter
DB00691MoexiprilSolute carrier family 15 member 2transporter
DB00691MoexiprilAngiotensin-converting enzyme 2target
DB00714ApomorphineD(2) dopamine receptortarget
DB00714ApomorphineD(1A) dopamine receptortarget
DB00714ApomorphineD(4) dopamine receptortarget
DB00714ApomorphineD(3) dopamine receptortarget
DB00714ApomorphineD(1B) dopamine receptortarget
DB00714ApomorphineNeuron-specific vesicular protein calcyontarget
DB00714ApomorphineAlpha-2C adrenergic receptortarget
DB00714ApomorphineAlpha-2B adrenergic receptortarget
DB00714Apomorphine5-hydroxytryptamine receptor 2Ctarget
DB00714Apomorphine5-hydroxytryptamine receptor 1Atarget
DB00714Apomorphine5-hydroxytryptamine receptor 2Atarget
DB00714Apomorphine5-hydroxytryptamine receptor 2Btarget
DB00714ApomorphineAlpha-2A adrenergic receptortarget
DB00714Apomorphine5-hydroxytryptamine receptor 1Dtarget
DB00714Apomorphine5-hydroxytryptamine receptor 1Btarget
DB00732Atracurium besylateNeuronal acetylcholine receptor subunit alpha-2target
DB00881QuinaprilAngiotensin-converting enzymetarget
DB00881QuinaprilSolute carrier family 15 member 1transporter
DB00881QuinaprilSolute carrier family 15 member 2transporter
DB00881QuinaprilSolute carrier family 22 member 8transporter
DB01058PraziquantelSchistosome calcium ion (Ca2+) channelstarget
DB01058PraziquantelCytochrome P450 3A4enzyme
DB01058PraziquantelCytochrome P450 1A2enzyme
DB01058PraziquantelCytochrome P450 2C19enzyme
DB01058PraziquantelCytochrome P450 3A43enzyme
DB01058PraziquantelCytochrome P450 3A5enzyme
DB01058PraziquantelCytochrome P450 3A7enzyme
DB01113PapaverinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB01113PapaverinecAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Atarget
DB01199TubocurarineNeuronal acetylcholine receptor subunit alpha-2target
DB01199TubocurarineAcetylcholinesterasetarget
DB01199Tubocurarine5-hydroxytryptamine receptor 3Atarget
DB01199TubocurarineSolute carrier family 22 member 1transporter
DB01199TubocurarineSolute carrier family 22 member 2transporter
DB01199TubocurarineNeuronal acetylcholine receptor subunit alpha-7target
DB01199TubocurarineCholinesteraseenzyme
DB01232SaquinavirHuman immunodeficiency virus type 1 proteasetarget
DB01232SaquinavirCytochrome P450 3A4enzyme
DB01232SaquinavirCytochrome P450 3A5enzyme
DB01232SaquinavirAlpha-1-acid glycoprotein 1carrier
DB01232SaquinavirSerum albumincarrier
DB01232SaquinavirCytochrome P450 3A7enzyme
DB01232SaquinavirMultidrug resistance protein 1transporter
DB01232SaquinavirSolute carrier family 22 member 1transporter
DB01232SaquinavirSolute carrier organic anion transporter family member 1A2transporter
DB01232SaquinavirATP-binding cassette sub-family G member 2transporter
DB01232SaquinavirSolute carrier organic anion transporter family member 1B1transporter
DB01232SaquinavirMultidrug resistance-associated protein 1transporter
DB01232SaquinavirCanalicular multispecific organic anion transporter 1transporter
DB01232SaquinavirCytochrome P450 2C8enzyme
DB01232SaquinavirCytochrome P450 2D6enzyme
DB01232SaquinavirSolute carrier organic anion transporter family member 2B1transporter
DB01232SaquinavirBile salt export pumptransporter
DB01336MetocurineNeuronal acetylcholine receptor subunit alpha-2target
DB01336MetocurineMuscarinic acetylcholine receptor M2target
DB01591SolifenacinMuscarinic acetylcholine receptor M3target
DB01591SolifenacinMuscarinic acetylcholine receptor M1target
DB01591SolifenacinCytochrome P450 3A4enzyme
DB01591SolifenacinMuscarinic acetylcholine receptor M2target
DB01591SolifenacinMuscarinic acetylcholine receptor M4target
DB01591SolifenacinMuscarinic acetylcholine receptor M5target
DB01591Solifenacinalpha1-acid glycoproteincarrier
DB01591SolifenacinCytochrome P450 1A1enzyme
DB01591SolifenacinCytochrome P450 2D6enzyme
DB04115BerberineHTH-type transcriptional regulator QacRtarget
DB04115BerberineBaculoviral IAP repeat-containing protein 5target
DB04707HydroxyfasudilRho-associated protein kinase 1target
DB04707HydroxyfasudilcAMP-dependent protein kinase catalytic subunit alphatarget
DB04707HydroxyfasudilcAMP-dependent protein kinase inhibitor alphatarget
DB04821NomifensineSodium-dependent noradrenaline transportertarget
DB04821NomifensineSodium-dependent dopamine transportertarget
DB04821NomifensineAlpha-1-acid glycoprotein 1carrier
DB04821NomifensineAmine oxidase [flavin-containing] Btarget
DB04821NomifensineAmine oxidase [flavin-containing] Atarget
DB04821NomifensineMyeloperoxidasetarget
DB04821NomifensineSodium-dependent serotonin transportertarget
DB04821NomifensineSynaptic vesicular amine transportertarget
DB04840DebrisoquineSodium-dependent noradrenaline transportertarget
DB04840DebrisoquineCytochrome P450 2D6enzyme
DB04840DebrisoquineMultidrug resistance protein 1transporter
DB04840DebrisoquineCytochrome P450 1A1enzyme
DB04881ElacridarMultidrug resistance protein 1target
DB04881ElacridarATP-binding cassette sub-family G member 2transporter
DB04881ElacridarSolute carrier organic anion transporter family member 1B1transporter
DB05022AmonafideDNA topoisomerase 2-alphatarget
DB05022AmonafideDNA topoisomerase 2-betatarget
DB05109TrabectedinCytochrome P450 3A4enzyme
DB05109TrabectedinCytochrome P450 2C9enzyme
DB05109TrabectedinCytochrome P450 2D6enzyme
DB05109TrabectedinCytochrome P450 2E1enzyme
DB05109TrabectedinCytochrome P450 2C19enzyme
DB05109TrabectedinDNAtarget
DB05109TrabectedinProstaglandin G/H synthase 1enzyme
DB06174NoscapineSigma non-opioid intracellular receptor 1target
DB06174NoscapineCytochrome P450 2C9enzyme
DB06174NoscapineCytochrome P450 3A4enzyme
DB06751DrotaverinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB06751DrotaverineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB07419S-23Androgen receptortarget
DB079965-(2-methylpiperazine-1-sulfonyl)isoquinolinecAMP-dependent protein kinase catalytic subunit alphatarget
DB079965-(2-methylpiperazine-1-sulfonyl)isoquinolinecAMP-dependent protein kinase inhibitor alphatarget
DB085507,8-Dichloro-1,2,3,4-tetrahydroisoquinolinePhenylethanolamine N-methyltransferasetarget
DB12093TetrahydropalmatineD(1A) dopamine receptortarget
DB12093TetrahydropalmatineD(2) dopamine receptortarget
DB12093TetrahydropalmatineCytochrome P450 3A4enzyme
DB14066TetrandrineMultidrug resistance protein 1target
DB14066TetrandrineCytochrome P450 3A4enzyme
DB08162FasudilcAMP-dependent protein kinase inhibitor alphatarget
DB08162FasudilcAMP-dependent protein kinase catalytic subunit alphatarget
DB08162FasudilRho-associated protein kinase 1target
DB08162FasudilRho-associated protein kinase 2target
DB00377Palonosetron5-hydroxytryptamine receptor 3Atarget
DB00377PalonosetronCytochrome P450 2D6enzyme
DB00377PalonosetronCytochrome P450 3A4enzyme
DB00377PalonosetronCytochrome P450 1A2enzyme
DB01226MivacuriumNeuronal acetylcholine receptor subunit alpha-2target
DB01226MivacuriumMuscarinic acetylcholine receptor M2target
DB01226MivacuriumMuscarinic acetylcholine receptor M3target
DB01226MivacuriumCholinesterasetarget