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Identification
NameNelfinavir
Accession NumberDB00220  (APRD00003)
TypeSmall Molecule
GroupsApproved
DescriptionA potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. [PubChem]
Structure
Thumb
Synonyms
Viracept
External Identifiers
  • AG1343
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ViraceptTablet, film coated625 mg/1OralREMEDYREPACK INC.2013-03-272016-03-11Us
ViraceptTablet, film coated250 mg/1OralAGOURON1997-03-14Not applicableUs
ViraceptTablet, film coated250 mg/1OralH.J. Harkins Company, Inc.1997-03-14Not applicableUs
ViraceptPowder50 mg/gOralAGOURON1997-03-142016-02-26Us
ViraceptTablet625 mgOralPfizer Canada Inc2004-08-11Not applicableCanada
ViraceptTablet, film coated625 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
ViraceptTablet, film coated625 mg/1OralAGOURON2003-04-30Not applicableUs
ViraceptTablet, film coated250 mg/1OralPd Rx Pharmaceuticals, Inc.1997-03-14Not applicableUs
Viracept -250mgTablet250 mgOralPfizer Canada Inc1998-09-21Not applicableCanada
Viracept -50mgPowder50 mgOralPfizer Canada Inc1998-09-21Not applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Nelfinavir mesylate
ThumbNot applicableDBSALT000885
Categories
UNIIHO3OGH5D7I
CAS number159989-64-7
WeightAverage: 567.782
Monoisotopic: 567.313077633
Chemical FormulaC32H45N3O4S
InChI KeyQAGYKUNXZHXKMR-HKWSIXNMSA-N
InChI
InChI=1S/C32H45N3O4S/c1-21-25(15-10-16-28(21)36)30(38)33-26(20-40-24-13-6-5-7-14-24)29(37)19-35-18-23-12-9-8-11-22(23)17-27(35)31(39)34-32(2,3)4/h5-7,10,13-16,22-23,26-27,29,36-37H,8-9,11-12,17-20H2,1-4H3,(H,33,38)(H,34,39)/t22-,23+,26-,27-,29+/m0/s1
IUPAC Name
(3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylphenyl)formamido]-4-(phenylsulfanyl)butyl]-decahydroisoquinoline-3-carboxamide
SMILES
[H][C@@]12CCCC[C@]1([H])CN(C[C@@H](O)[[email protected]](CSC1=CC=CC=C1)NC(=O)C1=C(C)C(O)=CC=C1)[C@@H](C2)C(=O)NC(C)(C)C
Pharmacology
IndicationUsed in combination with other antiviral drugs in the treatment of HIV in both adults and children.
Structured Indications
PharmacodynamicsNelfinavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Nelfinavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.
Mechanism of actionNelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
TargetKindPharmacological actionActionsOrganismUniProt ID
HIV-1 proteaseProteinyes
inhibitor
Human immunodeficiency virusO90777 details
Related Articles
AbsorptionWell absorbed following oral administration.
Volume of distribution
  • 2 to 7 L/kg
Protein binding>98%
Metabolism

Primarily hepatic via cytochrome P450 (CYP450) enzymes. CYP3A and CYP2C19 appear to be the predominant enzymes that metabolize nelfinavir in humans. One major and several minor metabolites are found in plasma; the major oxidative metabolite has in vitro antiviral activity comparable to that of the parent drug.

Route of eliminationThe terminal half-life in plasma was typically 3.5 to 5 hours. The majority (87%) of an oral 750 mg dose containing 14C-nelfinavir was recovered in the feces; fecal radioactivity consisted of numerous oxidative metabolites (78%) and unchanged nelfinavir (22%). Only 1–2% of the dose was recovered in urine, of which unchanged nelfinavir was the major component.
Half life3.5 - 5 hours
ClearanceNot Available
ToxicityOral LD50 is over 5g/kg in rats. Side effects include thirst and hunger, unexplained weight loss, increased urination, fatigue, and dry, itchy skin.
Affected organisms
  • Human Immunodeficiency Virus
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be increased when it is combined with Nelfinavir.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be increased when it is combined with Nelfinavir.Experimental, Illicit
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Nelfinavir.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be increased when it is combined with Nelfinavir.Experimental, Illicit
AbacavirThe serum concentration of Abacavir can be decreased when it is combined with Nelfinavir.Approved, Investigational
AbirateroneThe metabolism of Abiraterone can be decreased when combined with Nelfinavir.Approved
AcarboseThe therapeutic efficacy of Acarbose can be decreased when used in combination with Nelfinavir.Approved, Investigational
AcebutololThe serum concentration of Acebutolol can be decreased when it is combined with Nelfinavir.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Nelfinavir.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Nelfinavir.Approved
AcetohexamideThe therapeutic efficacy of Acetohexamide can be decreased when used in combination with Nelfinavir.Withdrawn
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be decreased when it is combined with Nelfinavir.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Nelfinavir.Approved
AfatinibThe serum concentration of Afatinib can be decreased when it is combined with Nelfinavir.Approved
AicarThe therapeutic efficacy of Aicar can be decreased when used in combination with Nelfinavir.Experimental
AlbendazoleThe metabolism of Albendazole can be decreased when combined with Nelfinavir.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be decreased when combined with Nelfinavir.Approved
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Nelfinavir.Experimental
AlectinibThe serum concentration of Nelfinavir can be increased when it is combined with Alectinib.Approved
AlfentanilThe metabolism of Alfentanil can be decreased when combined with Nelfinavir.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Nelfinavir.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be decreased when combined with Nelfinavir.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be decreased when it is combined with Nelfinavir.Approved, Investigational
AllylestrenolThe metabolism of Allylestrenol can be decreased when combined with Nelfinavir.Approved
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Nelfinavir.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Nelfinavir.Approved
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Nelfinavir.Approved, Withdrawn
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Nelfinavir.Approved, Illicit, Investigational
AmantadineThe serum concentration of Nelfinavir can be increased when it is combined with Amantadine.Approved
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Nelfinavir.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be decreased when combined with Nelfinavir.Approved
Ambroxol acefyllinateThe serum concentration of Ambroxol acefyllinate can be decreased when it is combined with Nelfinavir.Experimental
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Nelfinavir.Approved
AmineptineThe serum concentration of Amineptine can be increased when it is combined with Nelfinavir.Illicit, Withdrawn
Aminohippuric acidThe serum concentration of Nelfinavir can be increased when it is combined with Aminohippuric acid.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Nelfinavir.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be decreased when combined with Nelfinavir.Approved
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Nelfinavir.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Nelfinavir.Approved
AmlodipineThe metabolism of Amlodipine can be decreased when combined with Nelfinavir.Approved
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Nelfinavir.Approved, Vet Approved
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Nelfinavir.Approved
AmsacrineThe serum concentration of Nelfinavir can be increased when it is combined with Amsacrine.Approved
AnagrelideNelfinavir may increase the QTc-prolonging activities of Anagrelide.Approved
AnecortaveThe serum concentration of Anecortave can be increased when it is combined with Nelfinavir.Investigational
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Nelfinavir.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Nelfinavir.Approved
ApremilastThe metabolism of Apremilast can be decreased when combined with Nelfinavir.Approved, Investigational
AprepitantThe serum concentration of Nelfinavir can be increased when it is combined with Aprepitant.Approved, Investigational
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Nelfinavir.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be decreased when combined with Nelfinavir.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Nelfinavir.Approved, Investigational
ArmodafinilThe metabolism of Nelfinavir can be decreased when combined with Armodafinil.Approved, Investigational
Arsenic trioxideNelfinavir may increase the QTc-prolonging activities of Arsenic trioxide.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Nelfinavir.Approved
AsenapineThe serum concentration of Nelfinavir can be decreased when it is combined with Asenapine.Approved
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Nelfinavir.Approved, Withdrawn
AtazanavirThe metabolism of Atazanavir can be decreased when combined with Nelfinavir.Approved, Investigational
AtenololThe serum concentration of Atenolol can be decreased when it is combined with Nelfinavir.Approved
AtomoxetineThe metabolism of Nelfinavir can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Nelfinavir.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Nelfinavir.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Nelfinavir.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Nelfinavir.Approved
AzithromycinThe metabolism of Azithromycin can be decreased when combined with Nelfinavir.Approved
AzithromycinThe serum concentration of Azithromycin can be increased when it is combined with Nelfinavir.Approved
BalaglitazoneThe therapeutic efficacy of Balaglitazone can be decreased when used in combination with Nelfinavir.Investigational
BanoxantroneThe metabolism of Banoxantrone can be decreased when combined with Nelfinavir.Investigational
BarnidipineThe serum concentration of Barnidipine can be increased when it is combined with Nelfinavir.Approved
BeclomethasoneThe serum concentration of Beclomethasone can be increased when it is combined with Nelfinavir.Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Nelfinavir.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Nelfinavir.Approved
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Nelfinavir.Approved
BenzocaineThe serum concentration of Nelfinavir can be increased when it is combined with Benzocaine.Approved
BenzphetamineThe metabolism of Benzphetamine can be decreased when combined with Nelfinavir.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Nelfinavir.Approved
BepridilThe serum concentration of Nelfinavir can be increased when it is combined with Bepridil.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Nelfinavir.Approved, Vet Approved
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Nelfinavir.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be decreased when combined with Nelfinavir.Approved
BicalutamideThe metabolism of Bicalutamide can be decreased when combined with Nelfinavir.Approved
BiperidenThe serum concentration of Nelfinavir can be increased when it is combined with Biperiden.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Nelfinavir.Approved
BoceprevirThe serum concentration of Nelfinavir can be decreased when it is combined with Boceprevir.Approved
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Nelfinavir.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Nelfinavir.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Nelfinavir.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Nelfinavir.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Nelfinavir.Approved
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Nelfinavir.Approved
BromazepamThe metabolism of Bromazepam can be decreased when combined with Nelfinavir.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Nelfinavir.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Nelfinavir.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Nelfinavir.Approved
BudesonideThe metabolism of Budesonide can be decreased when combined with Nelfinavir.Approved
BuforminThe therapeutic efficacy of Buformin can be decreased when used in combination with Nelfinavir.Withdrawn
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Nelfinavir.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Nelfinavir.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Nelfinavir.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Nelfinavir.Approved, Investigational
BusulfanThe metabolism of Busulfan can be decreased when combined with Nelfinavir.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Nelfinavir.Approved
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Nelfinavir.Approved
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Nelfinavir.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Nelfinavir.Approved
CalcitriolThe metabolism of Calcitriol can be decreased when combined with Nelfinavir.Approved, Nutraceutical
CamptothecinThe serum concentration of Camptothecin can be decreased when it is combined with Nelfinavir.Experimental
CanagliflozinThe metabolism of Canagliflozin can be decreased when combined with Nelfinavir.Approved
CandesartanThe serum concentration of Nelfinavir can be increased when it is combined with Candesartan.Approved
CaptoprilThe serum concentration of Nelfinavir can be increased when it is combined with Captopril.Approved
CarbamazepineThe metabolism of Nelfinavir can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Nelfinavir.Approved
CarfilzomibThe serum concentration of Carfilzomib can be decreased when it is combined with Nelfinavir.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Nelfinavir.Approved
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Nelfinavir.Approved
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Nelfinavir.Approved, Investigational
CaspofunginThe serum concentration of Nelfinavir can be increased when it is combined with Caspofungin.Approved
CastanospermineThe therapeutic efficacy of Castanospermine can be decreased when used in combination with Nelfinavir.Experimental
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Nelfinavir.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be decreased when combined with Nelfinavir.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Nelfinavir.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be increased when it is combined with Nelfinavir.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Nelfinavir.Withdrawn
CevimelineThe metabolism of Cevimeline can be decreased when combined with Nelfinavir.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be decreased when combined with Nelfinavir.Approved
ChloramphenicolThe metabolism of Nelfinavir can be decreased when combined with Chloramphenicol.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Nelfinavir.Approved, Illicit
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Nelfinavir.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Nelfinavir.Withdrawn
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Nelfinavir.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be decreased when combined with Nelfinavir.Approved, Vet Approved
ChlorpropamideThe serum concentration of Nelfinavir can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Nelfinavir can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Nelfinavir.Approved
CholecalciferolThe metabolism of Cholecalciferol can be decreased when combined with Nelfinavir.Approved, Nutraceutical
CholesterolThe serum concentration of Nelfinavir can be increased when it is combined with Cholesterol.Experimental
Cholic AcidThe serum concentration of Nelfinavir can be decreased when it is combined with Cholic Acid.Approved
CiclesonideThe metabolism of Ciclesonide can be decreased when combined with Nelfinavir.Approved, Investigational
CiglitazoneThe therapeutic efficacy of Ciglitazone can be decreased when used in combination with Nelfinavir.Experimental
CilazaprilThe serum concentration of Nelfinavir can be increased when it is combined with Cilazapril.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Nelfinavir.Approved
CimetidineThe serum concentration of Nelfinavir can be decreased when it is combined with Cimetidine.Approved
CinacalcetThe metabolism of Cinacalcet can be decreased when combined with Nelfinavir.Approved
CiprofloxacinNelfinavir may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Nelfinavir.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be decreased when it is combined with Nelfinavir.Approved
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Nelfinavir.Approved
ClarithromycinThe therapeutic efficacy of Clarithromycin can be decreased when used in combination with Nelfinavir.Approved
ClemastineThe metabolism of Nelfinavir can be decreased when combined with Clemastine.Approved
ClindamycinThe metabolism of Clindamycin can be decreased when combined with Nelfinavir.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Nelfinavir.Approved, Illicit
ClobetasolThe serum concentration of Clobetasol can be increased when it is combined with Nelfinavir.Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Nelfinavir.Approved
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Nelfinavir.Approved
ClofazimineThe metabolism of Clofazimine can be decreased when combined with Nelfinavir.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be decreased when combined with Nelfinavir.Approved
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Nelfinavir.Investigational
ClomifeneThe serum concentration of Clomifene can be decreased when it is combined with Nelfinavir.Approved, Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Nelfinavir.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be decreased when combined with Nelfinavir.Approved, Illicit
ClonidineThe metabolism of Clonidine can be decreased when combined with Nelfinavir.Approved
ClopidogrelThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Nelfinavir resulting in a loss in efficacy.Approved, Nutraceutical
ClorazepateThe metabolism of Clorazepate can be decreased when combined with Nelfinavir.Approved, Illicit
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Nelfinavir.Approved, Illicit
ClotrimazoleThe metabolism of Nelfinavir can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Nelfinavir.Approved
CobicistatThe metabolism of Nelfinavir can be decreased when combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Nelfinavir.Approved
CocaineThe metabolism of Cocaine can be decreased when combined with Nelfinavir.Approved, Illicit
CodeineThe metabolism of Codeine can be decreased when combined with Nelfinavir.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Nelfinavir.Approved
ColforsinThe serum concentration of Nelfinavir can be increased when it is combined with Colforsin.Experimental
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Nelfinavir.Approved, Investigational
Conjugated Equine EstrogensThe metabolism of Conjugated Equine Estrogens can be decreased when combined with Nelfinavir.Approved
Cortisone acetateThe metabolism of Cortisone acetate can be decreased when combined with Nelfinavir.Approved
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Nelfinavir.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be decreased when combined with Nelfinavir.Approved
CyclophosphamideThe risk or severity of adverse effects can be increased when Nelfinavir is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Nelfinavir.Approved, Investigational, Vet Approved
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Nelfinavir.Approved, Investigational, Vet Approved
CytarabineThe metabolism of Cytarabine can be decreased when combined with Nelfinavir.Approved, Investigational
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be decreased when it is combined with Nelfinavir.Approved
DabrafenibThe serum concentration of Nelfinavir can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Nelfinavir.Approved
DactinomycinThe serum concentration of Dactinomycin can be decreased when it is combined with Nelfinavir.Approved
DantroleneThe metabolism of Dantrolene can be decreased when combined with Nelfinavir.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Nelfinavir.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Nelfinavir.Investigational
DapsoneThe metabolism of Dapsone can be decreased when combined with Nelfinavir.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Nelfinavir.Approved, Investigational
DarunavirThe metabolism of Darunavir can be decreased when combined with Nelfinavir.Approved
DasabuvirThe metabolism of Dasabuvir can be decreased when combined with Nelfinavir.Approved
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Nelfinavir.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be decreased when combined with Nelfinavir.Approved
DebrisoquinThe serum concentration of Debrisoquin can be decreased when it is combined with Nelfinavir.Approved
DeferasiroxThe serum concentration of Nelfinavir can be decreased when it is combined with Deferasirox.Approved, Investigational
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Nelfinavir.Investigational
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Nelfinavir.Approved
DeoxyspergualinThe therapeutic efficacy of Deoxyspergualin can be decreased when used in combination with Nelfinavir.Investigational
DesipramineThe serum concentration of Desipramine can be increased when it is combined with Nelfinavir.Approved
DesloratadineThe serum concentration of Nelfinavir can be increased when it is combined with Desloratadine.Approved, Investigational
DesogestrelThe serum concentration of Desogestrel can be decreased when it is combined with Nelfinavir.Approved
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Nelfinavir.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Nelfinavir.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be increased when it is combined with Nelfinavir.Experimental, Vet Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be decreased when combined with Nelfinavir.Approved
DexamethasoneThe metabolism of Dexamethasone can be decreased when combined with Nelfinavir.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Nelfinavir.Vet Approved
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Nelfinavir.Approved
DextropropoxypheneThe metabolism of Dextropropoxyphene can be decreased when combined with Nelfinavir.Approved, Illicit, Withdrawn
DiazepamThe metabolism of Diazepam can be decreased when combined with Nelfinavir.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Nelfinavir.Approved, Vet Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Nelfinavir.Approved
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Nelfinavir.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Nelfinavir.Approved
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Nelfinavir.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Nelfinavir.Approved
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Nelfinavir.Approved
DigitoxinThe metabolism of Digitoxin can be decreased when combined with Nelfinavir.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Nelfinavir.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be decreased when combined with Nelfinavir.Approved, Illicit
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Nelfinavir.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Nelfinavir.Illicit
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Nelfinavir.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Nelfinavir.Approved
DipyridamoleThe serum concentration of Dipyridamole can be decreased when it is combined with Nelfinavir.Approved
DisopyramideThe metabolism of Disopyramide can be decreased when combined with Nelfinavir.Approved
DisulfiramThe metabolism of Disulfiram can be decreased when combined with Nelfinavir.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Nelfinavir.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Nelfinavir.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Nelfinavir.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Nelfinavir.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Nelfinavir.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Nelfinavir.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Nelfinavir.Approved
DosulepinThe serum concentration of Dosulepin can be increased when it is combined with Nelfinavir.Approved
DoxazosinThe serum concentration of Nelfinavir can be increased when it is combined with Doxazosin.Approved
DoxepinThe serum concentration of Nelfinavir can be decreased when it is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Nelfinavir.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Nelfinavir.Approved, Investigational
DoxycyclineThe metabolism of Nelfinavir can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Nelfinavir.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Nelfinavir.Approved
DroperidolNelfinavir may increase the QTc-prolonging activities of Droperidol.Approved, Vet Approved
DrospirenoneThe serum concentration of Drospirenone can be decreased when it is combined with Nelfinavir.Approved
DulaglutideThe therapeutic efficacy of Dulaglutide can be decreased when used in combination with Nelfinavir.Approved
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Nelfinavir.Approved, Investigational
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Nelfinavir.Approved
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Nelfinavir.Approved
EfavirenzThe metabolism of Efavirenz can be decreased when combined with Nelfinavir.Approved, Investigational
ElbasvirThe serum concentration of Nelfinavir can be increased when it is combined with Elbasvir.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Nelfinavir.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Nelfinavir.Approved
ElvitegravirThe metabolism of Elvitegravir can be decreased when combined with Nelfinavir.Approved
EmpagliflozinThe therapeutic efficacy of Empagliflozin can be decreased when used in combination with Nelfinavir.Approved
EnalaprilThe metabolism of Enalapril can be decreased when combined with Nelfinavir.Approved, Vet Approved
EnfuvirtideThe serum concentration of Enfuvirtide can be increased when it is combined with Nelfinavir.Approved, Investigational
EnzalutamideThe serum concentration of Nelfinavir can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe serum concentration of Nelfinavir can be decreased when it is combined with Epinastine.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Nelfinavir.Approved
EquileninThe serum concentration of Equilenin can be increased when it is combined with Nelfinavir.Experimental
EquilinThe serum concentration of Equilin can be increased when it is combined with Nelfinavir.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be decreased when combined with Nelfinavir.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Nelfinavir.Approved
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Nelfinavir.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Nelfinavir.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Nelfinavir.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be decreased when combined with Nelfinavir.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Nelfinavir.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Nelfinavir can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmirtazapineThe serum concentration of Esmirtazapine can be increased when it is combined with Nelfinavir.Investigational
EsomeprazoleThe serum concentration of the active metabolites of Nelfinavir can be reduced when Nelfinavir is used in combination with Esomeprazole resulting in a loss in efficacy.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Nelfinavir.Approved, Illicit
EstradiolThe metabolism of Estradiol can be decreased when combined with Nelfinavir.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be decreased when combined with Nelfinavir.Approved
EstramustineThe metabolism of Estramustine can be decreased when combined with Nelfinavir.Approved
EstriolThe serum concentration of Estriol can be decreased when it is combined with Nelfinavir.Approved, Vet Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Nelfinavir.Approved
EstroneThe metabolism of Estrone can be decreased when combined with Nelfinavir.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be decreased when combined with Nelfinavir.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Nelfinavir.Approved
EthanolThe metabolism of Ethanol can be decreased when combined with Nelfinavir.Approved
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be decreased when combined with Nelfinavir.Approved
EthosuximideThe metabolism of Ethosuximide can be decreased when combined with Nelfinavir.Approved
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Nelfinavir.Approved, Illicit
Ethynodiol diacetateThe serum concentration of Ethynodiol diacetate can be decreased when it is combined with Nelfinavir.Approved
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Nelfinavir.Approved
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Nelfinavir.Approved, Investigational
EtoposideThe metabolism of Etoposide can be decreased when combined with Nelfinavir.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Nelfinavir.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Nelfinavir.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Nelfinavir.Approved
ExemestaneThe metabolism of Exemestane can be decreased when combined with Nelfinavir.Approved, Investigational
ExenatideThe therapeutic efficacy of Exenatide can be decreased when used in combination with Nelfinavir.Approved, Investigational
EzetimibeThe serum concentration of Ezetimibe can be decreased when it is combined with Nelfinavir.Approved
FamciclovirThe metabolism of Famciclovir can be decreased when combined with Nelfinavir.Approved
FamotidineThe serum concentration of Nelfinavir can be decreased when it is combined with Famotidine.Approved
FelbamateThe metabolism of Felbamate can be decreased when combined with Nelfinavir.Approved
FelodipineThe metabolism of Felodipine can be decreased when combined with Nelfinavir.Approved, Investigational
FenofibrateThe metabolism of Fenofibrate can be decreased when combined with Nelfinavir.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Nelfinavir.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Nelfinavir.Approved
FexofenadineThe serum concentration of Fexofenadine can be decreased when it is combined with Nelfinavir.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be decreased when it is combined with Nelfinavir.Approved
FinasterideThe metabolism of Finasteride can be decreased when combined with Nelfinavir.Approved
FingolimodThe metabolism of Fingolimod can be decreased when combined with Nelfinavir.Approved, Investigational
FlecainideNelfinavir may increase the QTc-prolonging activities of Flecainide.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Nelfinavir.Approved
fluasteroneThe serum concentration of fluasterone can be increased when it is combined with Nelfinavir.Investigational
FluconazoleThe metabolism of Nelfinavir can be decreased when combined with Fluconazole.Approved
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Nelfinavir.Approved
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Nelfinavir.Approved, Vet Approved
FlunisolideThe metabolism of Flunisolide can be decreased when combined with Nelfinavir.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Nelfinavir.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Nelfinavir.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Nelfinavir.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Nelfinavir.Approved, Withdrawn
FluorometholoneThe metabolism of Fluorometholone can be decreased when combined with Nelfinavir.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Nelfinavir.Approved, Vet Approved
FlupentixolNelfinavir may increase the QTc-prolonging activities of Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Nelfinavir can be increased when it is combined with Fluphenazine.Approved
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Nelfinavir.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Nelfinavir.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Nelfinavir.Approved
FlurazepamThe metabolism of Flurazepam can be decreased when combined with Nelfinavir.Approved, Illicit
FlutamideThe metabolism of Flutamide can be decreased when combined with Nelfinavir.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be decreased when combined with Nelfinavir.Approved
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Nelfinavir.Approved
Fluticasone PropionateThe metabolism of Fluticasone Propionate can be decreased when combined with Nelfinavir.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Nelfinavir.Approved
FluvoxamineThe metabolism of Nelfinavir can be decreased when combined with Fluvoxamine.Approved, Investigational
FormestaneThe serum concentration of Formestane can be increased when it is combined with Nelfinavir.Approved, Investigational, Withdrawn
FormoterolThe metabolism of Formoterol can be decreased when combined with Nelfinavir.Approved, Investigational
FosamprenavirThe metabolism of Fosamprenavir can be decreased when combined with Nelfinavir.Approved
FosaprepitantThe serum concentration of Nelfinavir can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Nelfinavir can be decreased when it is combined with Fosphenytoin.Approved
FulvestrantThe metabolism of Fulvestrant can be decreased when combined with Nelfinavir.Approved, Investigational
Fusidic AcidThe serum concentration of Nelfinavir can be increased when it is combined with Fusidic Acid.Approved
Gadobenic acidNelfinavir may increase the QTc-prolonging activities of Gadobenic acid.Approved
GalantamineThe metabolism of Galantamine can be decreased when combined with Nelfinavir.Approved
GarlicThe serum concentration of Nelfinavir can be decreased when it is combined with Garlic.Approved
GefitinibThe metabolism of Gefitinib can be decreased when combined with Nelfinavir.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be decreased when it is combined with Nelfinavir.Approved
GemfibrozilThe metabolism of Gemfibrozil can be decreased when combined with Nelfinavir.Approved
GemifloxacinNelfinavir may increase the QTc-prolonging activities of Gemifloxacin.Approved, Investigational
GenisteinThe serum concentration of Nelfinavir can be increased when it is combined with Genistein.Investigational
GestodeneThe serum concentration of Gestodene can be decreased when it is combined with Nelfinavir.Approved
GlibornurideThe therapeutic efficacy of Glibornuride can be decreased when used in combination with Nelfinavir.Withdrawn
GliclazideThe metabolism of Gliclazide can be decreased when combined with Nelfinavir.Approved
GlimepirideThe therapeutic efficacy of Glimepiride can be decreased when used in combination with Nelfinavir.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Nelfinavir.Approved
GliquidoneThe therapeutic efficacy of Gliquidone can be decreased when used in combination with Nelfinavir.Approved
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Nelfinavir.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Nelfinavir.Approved
GlycerolThe serum concentration of Nelfinavir can be increased when it is combined with Glycerol.Experimental
GoserelinNelfinavir may increase the QTc-prolonging activities of Goserelin.Approved
Gramicidin DThe serum concentration of Nelfinavir can be increased when it is combined with Gramicidin D.Approved
GranisetronThe metabolism of Granisetron can be decreased when combined with Nelfinavir.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be decreased when it is combined with Nelfinavir.Approved
GrepafloxacinThe metabolism of Grepafloxacin can be decreased when combined with Nelfinavir.Withdrawn
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Nelfinavir.Approved, Investigational
GusperimusThe therapeutic efficacy of Gusperimus can be decreased when used in combination with Nelfinavir.Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Nelfinavir.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Nelfinavir.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Nelfinavir.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be increased when it is combined with Nelfinavir.Investigational
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Nelfinavir.Withdrawn
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Nelfinavir.Approved
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Nelfinavir.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Nelfinavir.Approved, Illicit
HydrocortisoneThe metabolism of Hydrocortisone can be decreased when combined with Nelfinavir.Approved, Vet Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Nelfinavir.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be decreased when combined with Nelfinavir.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Nelfinavir.Approved
IbuprofenThe serum concentration of Ibuprofen can be decreased when it is combined with Nelfinavir.Approved
IbutilideNelfinavir may increase the QTc-prolonging activities of Ibutilide.Approved
IdelalisibThe serum concentration of Nelfinavir can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Nelfinavir resulting in a loss in efficacy.Approved
IloperidoneThe serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Nelfinavir.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Nelfinavir.Approved
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Nelfinavir.Approved
ImipramineThe metabolism of Imipramine can be decreased when combined with Nelfinavir.Approved
ImiquimodThe metabolism of Imiquimod can be decreased when combined with Nelfinavir.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be decreased when combined with Nelfinavir.Approved
IndapamideThe metabolism of Indapamide can be decreased when combined with Nelfinavir.Approved
IndinavirThe metabolism of Indinavir can be decreased when combined with Nelfinavir.Approved
IndomethacinThe serum concentration of Indomethacin can be decreased when it is combined with Nelfinavir.Approved, Investigational
Insulin AspartThe therapeutic efficacy of Insulin Aspart can be decreased when used in combination with Nelfinavir.Approved
Insulin DetemirThe therapeutic efficacy of Insulin Detemir can be decreased when used in combination with Nelfinavir.Approved
Insulin GlargineThe therapeutic efficacy of Insulin Glargine can be decreased when used in combination with Nelfinavir.Approved
Insulin GlulisineThe therapeutic efficacy of Insulin Glulisine can be decreased when used in combination with Nelfinavir.Approved
Insulin LisproThe therapeutic efficacy of Insulin Lispro can be decreased when used in combination with Nelfinavir.Approved
Insulin PorkThe therapeutic efficacy of Insulin Pork can be decreased when used in combination with Nelfinavir.Approved
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Nelfinavir.Approved
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Nelfinavir.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Nelfinavir.Approved, Investigational
IsoniazidThe metabolism of Nelfinavir can be decreased when combined with Isoniazid.Approved
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be decreased when combined with Nelfinavir.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be decreased when combined with Nelfinavir.Approved
IsradipineThe metabolism of Isradipine can be decreased when combined with Nelfinavir.Approved
IstaroximeThe serum concentration of Istaroxime can be increased when it is combined with Nelfinavir.Investigational
ItraconazoleThe metabolism of Itraconazole can be decreased when combined with Nelfinavir.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Nelfinavir.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Nelfinavir.Approved
IvermectinThe metabolism of Ivermectin can be decreased when combined with Nelfinavir.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Nelfinavir.Approved, Investigational
IxazomibThe metabolism of Ixazomib can be decreased when combined with Nelfinavir.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Nelfinavir.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be decreased when combined with Nelfinavir.Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Nelfinavir.Approved
KetoconazoleThe metabolism of Ketoconazole can be decreased when combined with Nelfinavir.Approved, Investigational
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Nelfinavir.Approved
LamivudineThe serum concentration of Lamivudine can be decreased when it is combined with Nelfinavir.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be decreased when it is combined with Nelfinavir.Approved, Investigational
LansoprazoleThe serum concentration of the active metabolites of Nelfinavir can be reduced when Nelfinavir is used in combination with Lansoprazole resulting in a loss in efficacy.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Nelfinavir.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be decreased when combined with Nelfinavir.Investigational
LedipasvirThe serum concentration of Ledipasvir can be decreased when it is combined with Nelfinavir.Approved
LenalidomideThe serum concentration of Lenalidomide can be decreased when it is combined with Nelfinavir.Approved
LenvatinibThe metabolism of Lenvatinib can be decreased when combined with Nelfinavir.Approved
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Nelfinavir.Approved, Investigational
LetrozoleThe metabolism of Letrozole can be decreased when combined with Nelfinavir.Approved, Investigational
LeuprolideNelfinavir may increase the QTc-prolonging activities of Leuprolide.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be decreased when it is combined with Nelfinavir.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Nelfinavir.Approved
LevocetirizineThe metabolism of Levocetirizine can be decreased when combined with Nelfinavir.Approved
LevofloxacinNelfinavir may increase the QTc-prolonging activities of Levofloxacin.Approved, Investigational
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be decreased when combined with Nelfinavir.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Nelfinavir.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Nelfinavir.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be decreased when combined with Nelfinavir.Approved
LidocaineThe metabolism of Lidocaine can be decreased when combined with Nelfinavir.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Nelfinavir.Approved
LiothyronineThe serum concentration of Nelfinavir can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Nelfinavir can be decreased when it is combined with Liotrix.Approved
LiraglutideThe therapeutic efficacy of Liraglutide can be decreased when used in combination with Nelfinavir.Approved
LisinoprilThe serum concentration of Nelfinavir can be increased when it is combined with Lisinopril.Approved, Investigational
LisurideThe metabolism of Lisuride can be decreased when combined with Nelfinavir.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Nelfinavir.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Nelfinavir.Approved
LopinavirThe serum concentration of Lopinavir can be decreased when it is combined with Nelfinavir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Nelfinavir.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Nelfinavir.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Nelfinavir.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Nelfinavir.Approved, Investigational
LuliconazoleThe serum concentration of Nelfinavir can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Nelfinavir can be decreased when it is combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Nelfinavir.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Nelfinavir.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Nelfinavir.Approved
LynestrenolThe serum concentration of Lynestrenol can be decreased when it is combined with Nelfinavir.Investigational
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Nelfinavir.Approved
MannitolThe serum concentration of Mannitol can be decreased when it is combined with Nelfinavir.Approved, Investigational
MaprotilineThe serum concentration of Nelfinavir can be increased when it is combined with Maprotiline.Approved
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Nelfinavir.Approved, Investigational
ME-609The serum concentration of ME-609 can be increased when it is combined with Nelfinavir.Investigational
MebendazoleThe metabolism of Mebendazole can be decreased when combined with Nelfinavir.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Nelfinavir.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Nelfinavir.Approved
MefloquineThe metabolism of Mefloquine can be decreased when combined with Nelfinavir.Approved
Megestrol acetateThe serum concentration of Nelfinavir can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Nelfinavir.Approved, Nutraceutical, Vet Approved
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Nelfinavir.Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Nelfinavir.Approved, Vet Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Nelfinavir.Investigational, Withdrawn
MeprobamateThe serum concentration of Nelfinavir can be increased when it is combined with Meprobamate.Approved, Illicit
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Nelfinavir.Approved
MetforminThe therapeutic efficacy of Metformin can be decreased when used in combination with Nelfinavir.Approved
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Nelfinavir.Approved
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Nelfinavir.Experimental
MethanthelineThe serum concentration of Nelfinavir can be decreased when it is combined with Methantheline.Approved
MethaqualoneThe metabolism of Methaqualone can be decreased when combined with Nelfinavir.Illicit, Withdrawn
MethotrexateThe serum concentration of Methotrexate can be decreased when it is combined with Nelfinavir.Approved
MethoxsalenThe metabolism of Methoxsalen can be decreased when combined with Nelfinavir.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Nelfinavir.Approved, Vet Approved
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Nelfinavir.Approved
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Nelfinavir.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Nelfinavir.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be decreased when combined with Nelfinavir.Approved
MetiamideThe serum concentration of Nelfinavir can be decreased when it is combined with Metiamide.Experimental
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Nelfinavir.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Nelfinavir.Approved
MexiletineThe metabolism of Mexiletine can be decreased when combined with Nelfinavir.Approved
MianserinThe metabolism of Mianserin can be decreased when combined with Nelfinavir.Approved
MibefradilThe metabolism of Mibefradil can be decreased when combined with Nelfinavir.Withdrawn
MiconazoleThe metabolism of Miconazole can be decreased when combined with Nelfinavir.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Nelfinavir.Approved, Illicit
MifepristoneMifepristone may increase the QTc-prolonging activities of Nelfinavir.Approved, Investigational
MiglitolThe therapeutic efficacy of Miglitol can be decreased when used in combination with Nelfinavir.Approved
MiglustatThe therapeutic efficacy of Miglustat can be decreased when used in combination with Nelfinavir.Approved
MirabegronThe metabolism of Mirabegron can be decreased when combined with Nelfinavir.Approved
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Nelfinavir.Approved
MitiglinideThe therapeutic efficacy of Mitiglinide can be decreased when used in combination with Nelfinavir.Approved, Investigational
MitomycinThe serum concentration of Nelfinavir can be increased when it is combined with Mitomycin.Approved
MitotaneThe serum concentration of Nelfinavir can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be decreased when it is combined with Nelfinavir.Approved, Investigational
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Nelfinavir.Approved
ModafinilThe metabolism of Modafinil can be decreased when combined with Nelfinavir.Approved, Investigational
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Nelfinavir.Approved, Vet Approved
MontelukastThe metabolism of Montelukast can be decreased when combined with Nelfinavir.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Nelfinavir.Approved, Investigational
MoxifloxacinNelfinavir may increase the QTc-prolonging activities of Moxifloxacin.Approved, Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Nelfinavir.Approved, Investigational
NadololThe serum concentration of Nadolol can be decreased when it is combined with Nelfinavir.Approved
NafcillinThe serum concentration of Nelfinavir can be decreased when it is combined with Nafcillin.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Nelfinavir.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Nelfinavir.Approved, Vet Approved
NaltrexoneThe serum concentration of Nelfinavir can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaringeninThe serum concentration of Nelfinavir can be increased when it is combined with Naringenin.Experimental
NateglinideThe metabolism of Nateglinide can be decreased when combined with Nelfinavir.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be increased when it is combined with Nelfinavir.Investigational
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Nelfinavir.Approved, Withdrawn
NeostigmineThe serum concentration of Nelfinavir can be increased when it is combined with Neostigmine.Approved, Vet Approved
NetupitantThe serum concentration of Nelfinavir can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of the active metabolites of Nelfinavir can be reduced when Nelfinavir is used in combination with Nevirapine resulting in a loss in efficacy.Approved
NicardipineThe metabolism of Nicardipine can be decreased when combined with Nelfinavir.Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Nelfinavir.Approved
NifedipineThe metabolism of Nifedipine can be decreased when combined with Nelfinavir.Approved
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Nelfinavir.Approved, Investigational
NilutamideThe metabolism of Nilutamide can be decreased when combined with Nelfinavir.Approved
NilvadipineThe metabolism of Nilvadipine can be decreased when combined with Nelfinavir.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Nelfinavir.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Nelfinavir.Approved
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Nelfinavir.Approved
NitrazepamThe metabolism of Nitrazepam can be decreased when combined with Nelfinavir.Approved
NitrendipineThe metabolism of Nitrendipine can be decreased when combined with Nelfinavir.Approved
NizatidineThe serum concentration of Nelfinavir can be decreased when it is combined with Nizatidine.Approved
NorelgestrominThe serum concentration of Norelgestromin can be decreased when it is combined with Nelfinavir.Approved
NorethisteroneThe metabolism of Norethisterone can be decreased when combined with Nelfinavir.Approved
NorgestimateThe serum concentration of Norgestimate can be decreased when it is combined with Nelfinavir.Approved
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Nelfinavir.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Nelfinavir.Approved
OfloxacinNelfinavir may increase the QTc-prolonging activities of Ofloxacin.Approved
OlanzapineThe serum concentration of Nelfinavir can be decreased when it is combined with Olanzapine.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Nelfinavir.Approved
Oleoyl estroneThe serum concentration of Oleoyl estrone can be increased when it is combined with Nelfinavir.Investigational
OlopatadineThe metabolism of Olopatadine can be decreased when combined with Nelfinavir.Approved
OmbitasvirThe serum concentration of Ombitasvir can be decreased when it is combined with Nelfinavir.Approved
OmeprazoleThe serum concentration of the active metabolites of Nelfinavir can be reduced when Nelfinavir is used in combination with Omeprazole resulting in a loss in efficacy.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Nelfinavir.Approved
OpipramolThe serum concentration of Opipramol can be increased when it is combined with Nelfinavir.Investigational
OrphenadrineThe metabolism of Orphenadrine can be decreased when combined with Nelfinavir.Approved
OsimertinibThe serum concentration of Osimertinib can be increased when it is combined with Nelfinavir.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Nelfinavir.Approved
OxazepamThe metabolism of Oxazepam can be decreased when combined with Nelfinavir.Approved
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Nelfinavir.Approved
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Nelfinavir.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Nelfinavir is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Nelfinavir.Approved, Investigational, Vet Approved
P-NitrophenolThe serum concentration of Nelfinavir can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Nelfinavir.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Nelfinavir.Approved
PaliperidoneNelfinavir may increase the QTc-prolonging activities of Paliperidone.Approved
Palmitic AcidThe serum concentration of Nelfinavir can be increased when it is combined with Palmitic Acid.Experimental
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Nelfinavir.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Nelfinavir.Approved, Investigational
PantoprazoleThe serum concentration of the active metabolites of Nelfinavir can be reduced when Nelfinavir is used in combination with Pantoprazole resulting in a loss in efficacy.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Nelfinavir.Approved
ParamethasoneThe metabolism of Paramethasone can be decreased when combined with Nelfinavir.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Nelfinavir.Approved
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Nelfinavir.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be decreased when combined with Nelfinavir.Approved
ParoxetineThe serum concentration of Nelfinavir can be increased when it is combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Nelfinavir.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Nelfinavir.Approved
PentobarbitalThe metabolism of Nelfinavir can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelThe metabolism of Perampanel can be decreased when combined with Nelfinavir.Approved
PerflutrenNelfinavir may increase the QTc-prolonging activities of Perflutren.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Nelfinavir.Approved, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Nelfinavir.Approved
PerindoprilThe serum concentration of Nelfinavir can be increased when it is combined with Perindopril.Approved
PermethrinThe metabolism of Permethrin can be decreased when combined with Nelfinavir.Approved, Investigational
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Nelfinavir.Approved
PethidineThe risk or severity of adverse effects can be increased when Nelfinavir is combined with Pethidine.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Nelfinavir.Withdrawn
PhenforminThe therapeutic efficacy of Phenformin can be decreased when used in combination with Nelfinavir.Approved, Withdrawn
PhenobarbitalThe metabolism of Nelfinavir can be increased when combined with Phenobarbital.Approved
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be decreased when combined with Nelfinavir.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be decreased when combined with Nelfinavir.Approved
PhenytoinThe serum concentration of Phenytoin can be decreased when it is combined with Nelfinavir.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be decreased when combined with Nelfinavir.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Nelfinavir.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Nelfinavir.Approved
PinacidilThe metabolism of Pinacidil can be decreased when combined with Nelfinavir.Withdrawn
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Nelfinavir.Approved, Investigational
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Nelfinavir.Approved
PitavastatinThe serum concentration of Pitavastatin can be decreased when it is combined with Nelfinavir.Approved
Platelet Activating FactorThe serum concentration of Nelfinavir can be decreased when it is combined with Platelet Activating Factor.Experimental
PodofiloxThe metabolism of Podofilox can be decreased when combined with Nelfinavir.Approved
PomalidomideThe metabolism of Pomalidomide can be decreased when combined with Nelfinavir.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Nelfinavir.Approved
PosaconazoleThe metabolism of Posaconazole can be decreased when combined with Nelfinavir.Approved, Investigational, Vet Approved
PramlintideThe therapeutic efficacy of Pramlintide can be decreased when used in combination with Nelfinavir.Approved, Investigational
PranlukastThe serum concentration of Pranlukast can be increased when it is combined with Nelfinavir.Approved
PrasteroneThe metabolism of Prasterone can be decreased when combined with Nelfinavir.Approved, Nutraceutical
PrasugrelThe serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Nelfinavir resulting in a loss in efficacy.Approved
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Nelfinavir.Approved
PrazepamThe metabolism of Prazepam can be decreased when combined with Nelfinavir.Approved, Illicit
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Nelfinavir.Approved, Vet Approved
PrazosinThe serum concentration of Prazosin can be decreased when it is combined with Nelfinavir.Approved
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Nelfinavir.Approved
PrednisoloneThe metabolism of Prednisolone can be decreased when combined with Nelfinavir.Approved, Vet Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Nelfinavir.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Nelfinavir.Approved, Vet Approved
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Nelfinavir.Experimental
PrimaquineThe metabolism of Primaquine can be decreased when combined with Nelfinavir.Approved
PrimidoneThe metabolism of Nelfinavir can be increased when combined with Primidone.Approved, Vet Approved
ProbenecidThe serum concentration of Nelfinavir can be increased when it is combined with Probenecid.Approved
ProcainamideNelfinavir may increase the QTc-prolonging activities of Procainamide.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Nelfinavir.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Nelfinavir.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Nelfinavir.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Nelfinavir.Approved, Vet Approved
PromethazineThe serum concentration of Nelfinavir can be increased when it is combined with Promethazine.Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Nelfinavir.Approved
PropofolThe metabolism of Propofol can be decreased when combined with Nelfinavir.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Nelfinavir.Approved, Investigational
ProtriptylineThe serum concentration of Protriptyline can be increased when it is combined with Nelfinavir.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Nelfinavir.Approved
PyrazinamideThe metabolism of Pyrazinamide can be decreased when combined with Nelfinavir.Approved
QuazepamThe metabolism of Quazepam can be decreased when combined with Nelfinavir.Approved, Illicit
QuercetinThe serum concentration of Nelfinavir can be increased when it is combined with Quercetin.Experimental
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Nelfinavir.Approved
QuinacrineThe metabolism of Quinacrine can be decreased when combined with Nelfinavir.Approved
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Nelfinavir.Approved
QuinineThe metabolism of Quinine can be decreased when combined with Nelfinavir.Approved
RabeprazoleThe serum concentration of the active metabolites of Nelfinavir can be reduced when Nelfinavir is used in combination with Rabeprazole resulting in a loss in efficacy.Approved, Investigational
RaloxifeneThe metabolism of Raloxifene can be decreased when combined with Nelfinavir.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Nelfinavir.Approved, Investigational
RanitidineThe serum concentration of Nelfinavir can be decreased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Nelfinavir.Approved, Investigational
ReboxetineThe metabolism of Reboxetine can be decreased when combined with Nelfinavir.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Nelfinavir.Approved
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Nelfinavir.Approved, Investigational
ReserpineThe serum concentration of Reserpine can be decreased when it is combined with Nelfinavir.Approved
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Nelfinavir.Approved
RifabutinThe serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Nelfinavir.Approved
RifampicinThe serum concentration of Nelfinavir can be decreased when it is combined with Rifampicin.Approved
RifapentineThe metabolism of Nelfinavir can be increased when combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Nelfinavir.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Nelfinavir.Approved
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Nelfinavir.Approved
RimonabantThe metabolism of Rimonabant can be decreased when combined with Nelfinavir.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Nelfinavir.Approved
RisperidoneThe metabolism of Risperidone can be decreased when combined with Nelfinavir.Approved, Investigational
RitonavirThe metabolism of Ritonavir can be decreased when combined with Nelfinavir.Approved, Investigational
RivaroxabanThe metabolism of Rivaroxaban can be decreased when combined with Nelfinavir.Approved
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Nelfinavir.Investigational, Withdrawn
RolapitantThe metabolism of Rolapitant can be decreased when combined with Nelfinavir.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Nelfinavir.Approved, Investigational
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Nelfinavir.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Nelfinavir.Approved
RosiglitazoneThe therapeutic efficacy of Rosiglitazone can be decreased when used in combination with Nelfinavir.Approved, Investigational
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Nelfinavir.Approved
RotigotineThe metabolism of Rotigotine can be decreased when combined with Nelfinavir.Approved
Roxatidine acetateThe serum concentration of Nelfinavir can be decreased when it is combined with Roxatidine acetate.Approved
RoxithromycinThe metabolism of Roxithromycin can be decreased when combined with Nelfinavir.Approved, Withdrawn
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Nelfinavir.Approved
Salicylic acidThe serum concentration of Salicylic acid can be decreased when it is combined with Nelfinavir.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Nelfinavir.Approved
SaquinavirThe metabolism of Saquinavir can be decreased when combined with Nelfinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Nelfinavir.Approved
ScopolamineThe serum concentration of Nelfinavir can be increased when it is combined with Scopolamine.Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Nelfinavir.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Nelfinavir.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Nelfinavir.Approved, Investigational
SertindoleThe metabolism of Sertindole can be decreased when combined with Nelfinavir.Approved, Withdrawn
SertralineThe metabolism of Sertraline can be decreased when combined with Nelfinavir.Approved
SevofluraneThe metabolism of Sevoflurane can be decreased when combined with Nelfinavir.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be decreased when combined with Nelfinavir.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Nelfinavir.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Nelfinavir.Approved
SiltuximabThe serum concentration of Nelfinavir can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Nelfinavir.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Nelfinavir.Approved
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Nelfinavir.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Nelfinavir.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Nelfinavir.Approved
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Nelfinavir.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Nelfinavir.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Nelfinavir.Approved, Investigational
SotalolNelfinavir may increase the QTc-prolonging activities of Sotalol.Approved
SparfloxacinThe serum concentration of Sparfloxacin can be decreased when it is combined with Nelfinavir.Approved
SphingosineThe serum concentration of Sphingosine can be decreased when it is combined with Nelfinavir.Experimental
SpiramycinThe metabolism of Spiramycin can be decreased when combined with Nelfinavir.Approved
SpironolactoneThe serum concentration of Nelfinavir can be increased when it is combined with Spironolactone.Approved
St. John's WortThe metabolism of Nelfinavir can be increased when combined with St. John's Wort.Nutraceutical
StaurosporineThe serum concentration of Nelfinavir can be increased when it is combined with Staurosporine.Experimental
StiripentolThe serum concentration of Nelfinavir can be increased when it is combined with Stiripentol.Approved
StreptozocinThe serum concentration of Nelfinavir can be decreased when it is combined with Streptozocin.Approved
SufentanilThe metabolism of Sufentanil can be decreased when combined with Nelfinavir.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Nelfinavir.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Nelfinavir.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Nelfinavir.Approved
SulfisoxazoleNelfinavir may increase the QTc-prolonging activities of Sulfisoxazole.Approved, Vet Approved
SulodexideThe therapeutic efficacy of Sulodexide can be decreased when used in combination with Nelfinavir.Approved, Investigational
SumatriptanThe serum concentration of Nelfinavir can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe metabolism of Sunitinib can be decreased when combined with Nelfinavir.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Nelfinavir.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Nelfinavir.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Nelfinavir.Approved
TacrineThe serum concentration of Nelfinavir can be increased when it is combined with Tacrine.Withdrawn
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Nelfinavir.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Nelfinavir.Approved, Investigational
TAK-390MRThe serum concentration of the active metabolites of Nelfinavir can be reduced when Nelfinavir is used in combination with TAK-390MR resulting in a loss in efficacy.Investigational
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Nelfinavir.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Nelfinavir.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Nelfinavir.Approved
TasimelteonThe serum concentration of Tasimelteon can be increased when it is combined with Nelfinavir.Approved
TasosartanThe metabolism of Tasosartan can be decreased when combined with Nelfinavir.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be decreased when combined with Nelfinavir.Experimental
Taurocholic AcidThe serum concentration of Taurocholic Acid can be decreased when it is combined with Nelfinavir.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Nelfinavir.Approved
TelaprevirThe metabolism of Telaprevir can be decreased when combined with Nelfinavir.Approved
TelavancinNelfinavir may increase the QTc-prolonging activities of Telavancin.Approved
TelithromycinThe metabolism of Telithromycin can be decreased when combined with Nelfinavir.Approved
TelmisartanThe serum concentration of Nelfinavir can be increased when it is combined with Telmisartan.Approved, Investigational
TemazepamThe metabolism of Temazepam can be decreased when combined with Nelfinavir.Approved
TemsirolimusThe risk or severity of adverse effects can be increased when Nelfinavir is combined with Temsirolimus.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Nelfinavir.Approved
TerazosinThe serum concentration of Nelfinavir can be increased when it is combined with Terazosin.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Nelfinavir.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Nelfinavir.Withdrawn
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Nelfinavir.Investigational
TestosteroneThe metabolism of Testosterone can be decreased when combined with Nelfinavir.Approved, Investigational
TetrabenazineNelfinavir may increase the QTc-prolonging activities of Tetrabenazine.Approved
TetracyclineThe metabolism of Tetracycline can be decreased when combined with Nelfinavir.Approved, Vet Approved
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Nelfinavir.Approved, Investigational, Withdrawn
TheophyllineThe metabolism of Theophylline can be decreased when combined with Nelfinavir.Approved
ThiazolidinedioneThe therapeutic efficacy of Thiazolidinedione can be decreased when used in combination with Nelfinavir.Investigational
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Nelfinavir.Approved
ThiotepaThe metabolism of Thiotepa can be decreased when combined with Nelfinavir.Approved
TiagabineThe metabolism of Tiagabine can be decreased when combined with Nelfinavir.Approved
TianeptineThe serum concentration of Tianeptine can be increased when it is combined with Nelfinavir.Approved
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Nelfinavir resulting in a loss in efficacy.Approved
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Nelfinavir.Approved
TimololThe serum concentration of Timolol can be decreased when it is combined with Nelfinavir.Approved
TinidazoleThe metabolism of Tinidazole can be decreased when combined with Nelfinavir.Approved, Investigational
TiotropiumThe metabolism of Tiotropium can be decreased when combined with Nelfinavir.Approved
TipranavirThe serum concentration of Nelfinavir can be decreased when it is combined with Tipranavir.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Nelfinavir.Approved
TizanidineThe serum concentration of Tizanidine can be increased when it is combined with Nelfinavir.Approved
TocilizumabThe serum concentration of Nelfinavir can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Nelfinavir.Approved, Investigational
TolazamideThe therapeutic efficacy of Tolazamide can be decreased when used in combination with Nelfinavir.Approved
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Nelfinavir.Approved
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Nelfinavir.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Nelfinavir.Approved
TopiramateThe metabolism of Nelfinavir can be decreased when combined with Topiramate.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Nelfinavir.Approved, Investigational
ToremifeneThe risk or severity of adverse effects can be increased when Nelfinavir is combined with Toremifene.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Nelfinavir.Approved, Investigational
TramadolThe serum concentration of Tramadol can be increased when it is combined with Nelfinavir.Approved, Investigational
TranylcypromineThe metabolism of Nelfinavir can be decreased when combined with Tranylcypromine.Approved
Trastuzumab emtansineThe serum concentration of the active metabolites of Trastuzumab emtansine can be increased when Trastuzumab emtansine is used in combination with Nelfinavir.Approved
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Nelfinavir.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Nelfinavir.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be decreased when combined with Nelfinavir.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Nelfinavir.Approved
TrifluoperazineThe serum concentration of Nelfinavir can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Nelfinavir can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Nelfinavir.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Nelfinavir.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Nelfinavir.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Nelfinavir.Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be decreased when combined with Nelfinavir.Approved
UdenafilThe metabolism of Udenafil can be decreased when combined with Nelfinavir.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Nelfinavir.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be decreased when it is combined with Nelfinavir.Approved
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Nelfinavir.Investigational, Withdrawn
Valproic AcidThe serum concentration of Valproic Acid can be decreased when it is combined with Nelfinavir.Approved, Investigational
VandetanibThe metabolism of Vandetanib can be decreased when combined with Nelfinavir.Approved
VanoxerineThe metabolism of Vanoxerine can be decreased when combined with Nelfinavir.Investigational
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Nelfinavir.Approved
VecuroniumThe serum concentration of Vecuronium can be decreased when it is combined with Nelfinavir.Approved
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Nelfinavir.Approved
VenetoclaxThe metabolism of Venetoclax can be decreased when combined with Nelfinavir.Approved
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Nelfinavir.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Nelfinavir.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Nelfinavir.Investigational
VilanterolThe metabolism of Vilanterol can be decreased when combined with Nelfinavir.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Nelfinavir.Approved
VildagliptinThe therapeutic efficacy of Vildagliptin can be decreased when used in combination with Nelfinavir.Approved, Investigational
VinblastineThe metabolism of Vinblastine can be decreased when combined with Nelfinavir.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Nelfinavir.Approved, Investigational
VincristineThe metabolism of Vincristine can be decreased when combined with Nelfinavir.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Nelfinavir.Approved
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Nelfinavir.Approved, Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Nelfinavir.Approved
VogliboseThe therapeutic efficacy of Voglibose can be decreased when used in combination with Nelfinavir.Approved, Investigational
VorapaxarThe serum concentration of Vorapaxar can be increased when it is combined with Nelfinavir.Approved
VoriconazoleThe serum concentration of Nelfinavir can be increased when it is combined with Voriconazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Nelfinavir.Approved
WarfarinThe serum concentration of Warfarin can be decreased when it is combined with Nelfinavir.Approved
YohimbineThe metabolism of Yohimbine can be decreased when combined with Nelfinavir.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Nelfinavir.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Nelfinavir.Approved
ZaleplonThe metabolism of Zaleplon can be decreased when combined with Nelfinavir.Approved, Illicit, Investigational
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Nelfinavir.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Nelfinavir.Approved, Investigational, Withdrawn
ZimelidineThe serum concentration of Nelfinavir can be increased when it is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be decreased when combined with Nelfinavir.Approved
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Nelfinavir.Approved
ZomepiracThe metabolism of Zomepirac can be decreased when combined with Nelfinavir.Withdrawn
ZonisamideThe metabolism of Zonisamide can be decreased when combined with Nelfinavir.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Nelfinavir.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Nelfinavir.Approved, Investigational
Food Interactions
  • Food significantly increases absorption (2 to 3 times).
  • Take with food.
References
Synthesis Reference

DrugSyn.org

US5461154
General References
  1. Kaldor SW, Kalish VJ, Davies JF 2nd, Shetty BV, Fritz JE, Appelt K, Burgess JA, Campanale KM, Chirgadze NY, Clawson DK, Dressman BA, Hatch SD, Khalil DA, Kosa MB, Lubbehusen PP, Muesing MA, Patick AK, Reich SH, Su KS, Tatlock JH: Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease. J Med Chem. 1997 Nov 21;40(24):3979-85. [PubMed:9397180 ]
External Links
ATC CodesJ05AE04
AHFS Codes
  • 08:18.08.08
PDB Entries
FDA labelDownload (294 KB)
MSDSDownload (56.6 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.7472
Blood Brain Barrier-0.9659
Caco-2 permeable-0.7148
P-glycoprotein substrateSubstrate0.9332
P-glycoprotein inhibitor IInhibitor0.8121
P-glycoprotein inhibitor IIInhibitor0.7572
Renal organic cation transporterNon-inhibitor0.8178
CYP450 2C9 substrateNon-substrate0.7482
CYP450 2D6 substrateSubstrate0.8918
CYP450 3A4 substrateSubstrate0.7408
CYP450 1A2 substrateNon-inhibitor0.9085
CYP450 2C9 inhibitorNon-inhibitor0.7994
CYP450 2D6 inhibitorNon-inhibitor0.8071
CYP450 2C19 inhibitorNon-inhibitor0.6335
CYP450 3A4 inhibitorInhibitor0.5465
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8977
Ames testNon AMES toxic0.8008
CarcinogenicityNon-carcinogens0.8547
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.4704 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9786
hERG inhibition (predictor II)Inhibitor0.785
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Agouron pharmaceuticals inc
Packagers
Dosage forms
FormRouteStrength
PowderOral50 mg/g
TabletOral625 mg
Tablet, film coatedOral250 mg/1
Tablet, film coatedOral625 mg/1
TabletOral250 mg
PowderOral50 mg
Prices
Unit descriptionCostUnit
Viracept 625 mg tablet11.24USD tablet
Viracept 250 mg tablet3.46USD tablet
Viracept 50 mg/gm Powder0.54USD gm
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2173328 No1999-08-312014-10-07Canada
US5484926 No1994-04-072014-04-07Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point349.84 °CNot Available
water solubilitySlightly solubleNot Available
logP6Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00191 mg/mLALOGPS
logP4.61ALOGPS
logP4.72ChemAxon
logS-5.5ALOGPS
pKa (Strongest Acidic)9.32ChemAxon
pKa (Strongest Basic)8.18ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area101.9 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity162.67 m3·mol-1ChemAxon
Polarizability63.8 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentAlpha amino acid amides
Alternative Parents
Substituents
  • Alpha-amino acid amide
  • Piperidinecarboxylic acid
  • Piperidinecarboxamide
  • 2-piperidinecarboxamide
  • Benzoic acid or derivatives
  • Benzamide
  • Thiophenol ether
  • O-cresol
  • Benzoyl
  • Alkylarylthioether
  • Toluene
  • Phenol
  • Benzenoid
  • Piperidine
  • Monocyclic benzene moiety
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Secondary alcohol
  • Carboxamide group
  • 1,2-aminoalcohol
  • Azacycle
  • Organoheterocyclic compound
  • Sulfenyl compound
  • Thioether
  • Carboxylic acid amide
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human immunodeficiency virus
Pharmacological action
yes
Actions
inhibitor
General Function:
Aspartic-type endopeptidase activity
Specific Function:
Not Available
Gene Name:
HIV-1 protease
Uniprot ID:
O90777
Molecular Weight:
10724.61 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Garriga C, Perez-Elias MJ, Delgado R, Ruiz L, Najera R, Pumarola T, Alonso-Socas Mdel M, Garcia-Bujalance S, Menendez-Arias L: Mutational patterns and correlated amino acid substitutions in the HIV-1 protease after virological failure to nelfinavir- and lopinavir/ritonavir-based treatments. J Med Virol. 2007 Nov;79(11):1617-28. [PubMed:17854027 ]
  4. Wittayanarakul K, Hannongbua S, Feig M: Accurate prediction of protonation state as a prerequisite for reliable MM-PB(GB)SA binding free energy calculations of HIV-1 protease inhibitors. J Comput Chem. 2008 Apr 15;29(5):673-85. [PubMed:17849388 ]
  5. Dandache S, Sevigny G, Yelle J, Stranix BR, Parkin N, Schapiro JM, Wainberg MA, Wu JJ: In vitro antiviral activity and cross-resistance profile of PL-100, a novel protease inhibitor of human immunodeficiency virus type 1. Antimicrob Agents Chemother. 2007 Nov;51(11):4036-43. Epub 2007 Jul 16. [PubMed:17638694 ]
  6. Perez MA, Fernandes PA, Ramos MJ: Drug design: new inhibitors for HIV-1 protease based on Nelfinavir as lead. J Mol Graph Model. 2007 Oct;26(3):634-42. Epub 2007 Mar 24. [PubMed:17459746 ]
  7. Velazquez-Campoy A, Kiso Y, Freire E: The binding energetics of first- and second-generation HIV-1 protease inhibitors: implications for drug design. Arch Biochem Biophys. 2001 Jun 15;390(2):169-75. [PubMed:11396919 ]
  8. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Hesse LM, von Moltke LL, Shader RI, Greenblatt DJ: Ritonavir, efavirenz, and nelfinavir inhibit CYP2B6 activity in vitro: potential drug interactions with bupropion. Drug Metab Dispos. 2001 Feb;29(2):100-2. [PubMed:11159797 ]
  2. Tanabe M, Hashimoto M, Ono H: Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease. Eur J Pharmacol. 2008 Jul 28;589(1-3):102-5. doi: 10.1016/j.ejphar.2008.06.013. Epub 2008 Jun 7. [PubMed:18602099 ]
  3. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Perloff MD, von Moltke LL, Fahey JM, Daily JP, Greenblatt DJ: Induction of P-glycoprotein expression by HIV protease inhibitors in cell culture. AIDS. 2000 Jun 16;14(9):1287-9. [PubMed:10894301 ]
  2. Choo EF, Leake B, Wandel C, Imamura H, Wood AJ, Wilkinson GR, Kim RB: Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab Dispos. 2000 Jun;28(6):655-60. [PubMed:10820137 ]
  3. Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. [PubMed:12699389 ]
  4. Kim RB, Fromm MF, Wandel C, Leake B, Wood AJ, Roden DM, Wilkinson GR: The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest. 1998 Jan 15;101(2):289-94. [PubMed:9435299 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Secondary active organic cation transmembrane transporter activity
Specific Function:
Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine...
Gene Name:
SLC22A1
Uniprot ID:
O15245
Molecular Weight:
61153.345 Da
References
  1. Zhang L, Gorset W, Washington CB, Blaschke TF, Kroetz DL, Giacomini KM: Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system. Drug Metab Dispos. 2000 Mar;28(3):329-34. [PubMed:10681378 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. [PubMed:10421612 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from t...
Gene Name:
ABCG2
Uniprot ID:
Q9UNQ0
Molecular Weight:
72313.47 Da
References
  1. Gupta A, Zhang Y, Unadkat JD, Mao Q: HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP/ABCG2). J Pharmacol Exp Ther. 2004 Jul;310(1):334-41. Epub 2004 Mar 8. [PubMed:15007102 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
References
  1. Tirona RG, Leake BF, Wolkoff AW, Kim RB: Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. J Pharmacol Exp Ther. 2003 Jan;304(1):223-8. [PubMed:12490595 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23