Organophosphorus Compounds

Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.
DrugDrug NameDrug Description
DB00282Pamidronic acidA bisphosphonate used to treat Paget's disease, to treat hypercalcemia of malignancy, and to treat osteolytic bone lesions.
DB00300Tenofovir disoproxilA nucleotide analog reverse transcriptase inhibitor used in the treatment of Hepatitis B infection and used in the management of HIV-1 infection.
DB00369CidofovirAn antiviral agent used to treat Cytomegalovirus (CMV) retinitis in patients with AIDS.
DB00399Zoledronic acidA bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors.
DB00492FosinoprilAn ACE inhibitor used to treat mild to moderate hypertension, congestive heart failure, and to slow the progression of renal disease in hypertensive diabetics.
DB00529FoscarnetAn antiviral used to treat CMV, HIV, and HSV infections.
DB00531CyclophosphamideA nitrogen mustard used to treat lymphomas, myelomas, leukemia, mycosis fungoides, neuroblastoma, ovarian adenocarcinoma, retinoblastoma, and breast carcinoma.
DB00630Alendronic acidA bisphosphonate drug that prevents osteoclastic bone resorption and is used for the prevention and treatment of osteoporosis.
DB00677IsoflurophateFor use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia.
DB00710IbandronateA bisphosphonate used to treat osteoporosis in postmenopausal women.
DB00718Adefovir dipivoxilA nucleotide analog used to treat chronic hepatitis B.
DB00720Clodronic acidA bisphosphonate used to treat osteoporosis in postmenopausal women, hypercalcemia of malignancy, and osteolysis.
DB00772MalathionA parasympathomimetic organophosphate used to treat head lice.
DB00828FosfomycinA broad spectrum antibiotic used to treat uncomplicated urinary tract infections.
DB00884Risedronic acidA bisphosphonate used to treat osteoporosis and Paget's disease.
DB01057EchothiophateAn acetylcholinesterase inhibitor used in ophthalmic preparations to increase the drainage of intraocular fluid; most commonly used for the treatment of glaucoma.
DB01077Etidronic acidA bisphosphonate drug that prevents osteoclastic bone resorption; used for the prevention and treatment of osteoporosis.
DB01133Tiludronic acidA bisphosphonate used for the treatment of Paget's disease of bone.
DB01143AmifostineA cytoprotective adjuvant used for reduction in the cumulative renal toxicity in patients with ovarian cancer and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.
DB01181IfosfamideAn alkylating and immunosuppressive agent used in chemotherapy for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, osteocarcinoma, bladder cancer, small cell lung cancer, and non-Hodgkin's lymphoma.
DB01319FosamprenavirAn antiretroviral agent used for the treatment and postexposure prophylaxis of human immunodeficiency virus (HIV-1) infection.
DB02138Diethyl 4-MethylbenzylphosphonateNot Available
DB023472-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic AcidNot Available
DB02386Leucine Phosphonic AcidNot Available
DB02607Adenosine Phosphonoacetic AcidNot Available
DB02823Phosphonoacetic AcidA simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent. [PubChem]
DB02845Methylphosphinic AcidNot Available
DB02948FosmidomycinNot Available
DB03298PhenylphosphateNot Available
DB03347Triethyl PhosphateNot Available
DB03459Sparfosic acidSparfosic acid is a solid. This compound belongs to the n-acyl-alpha amino acids. These are compounds containing an alpha amino acid which bears an acyl group at the terminal nitrogen...
DB04572ThiotepaAn alkylating agent used to prevent graft rejection in stem cell transplantation and to treat a variety of malignancies including certain types of adenocarcinoma and superficial bladder carcinomas.
DB04695Farnesyl thiopyrophosphateNot Available
DB05192MB07811Investigated for use/treatment in hyperlipidemia.
DB05404AZD 3355Investigated for use/treatment in gastroesophageal reflux disease (GERD).
DB05518Managlinat dialanetilInvestigated for use/treatment in diabetes mellitus type 2.
DB05668PalifosfamideInvestigated for use/treatment in cancer/tumors (unspecified), lymphoma (unspecified), and sarcoma.
DB06091EvofosfamideInvestigated for use/treatment in solid tumors.
DB06166FosdevirineInvestigated for use/treatment in HIV infection and acquired immune deficiency syndrome (AIDS) and aids-related infections.
DB06177GlufosfamideInvestigated for use/treatment in pancreatic cancer, solid tumors, breast cancer, colorectal cancer, brain cancer, lung cancer, ovarian cancer, and sarcoma.
DB06255Incadronic acidFor the treatment of hypercalcemia associated with malignant disease.
DB06548Minodronic acidInvestigated for use/treatment in multiple myeloma, breast cancer, osteoporosis, and lung cancer.
DB06753TriclofosNot Annotated
DB07641Decyl(dimethyl)phosphine oxideNot Available
DB07780Farnesyl diphosphateNot Available
DB07841Geranylgeranyl diphosphateNot Available
DB07895ALPHA-HYDROXYFARNESYLPHOSPHONIC ACIDNot Available
DB09042Tedizolid phosphateAn antibiotic agent used to treat acute bacterial skin and skin structure infections caused by susceptible isolates of Gram-positive bacteria.
DB09138Technetium Tc-99m medronateA diagnostic radiopharmaceutical agent used as a bone imaging agent to delineate areas of altered osteogenesis.
DB11379ButonateNot Annotated
DB11390CoumaphosThis drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a...
DB11392CythioateCythioate is a member of the organothiophosphate compounds that is used as an insecticide and anthelmintic. It is mainly used in veterinary as a treatment for fleas.
DB11397DichlorvosDichlorvos or 2,2-dichlorovinyl dimethyl phosphate is a drug of the organophosphate class, frequently used as an insecticide for the control of indoor pests and for the protection of stored products...
DB11408FamphurNot Annotated
DB11412FenthionFenthion is an organothiophosphate drug used as an insecticide, avicide, and acaricide. Its mode of action is explained by cholinesterase enzyme inhibition, which is similar to other organophosphates. Fenthion is...
DB11448PhosmetPhosmet is a phthalimide-derived organophosphate. It is a non-specific insecticide. It is mainly used on apple trees to control codling moths. It is also used on other fruit crops, ornamentals,...
DB11456RonnelNot Annotated
DB11473MetrifonateMetrifonate or trichlorfon is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate.
DB11497SulfotepNot Annotated
DB11620Neridronic AcidNot Annotated
DB11747BarasertibBarasertib has been used in trials studying the treatment of Tumors, Lymphoma, Solid Tumors, Solid Tumours, and Myeloid Leukemia, among others.
DB11768ZytronZytron (DMPA) is under investigation for the treatment and health services research of HIV, Lactation, Contraception, Postpartum Depression, and Immune Cells (Mucosal and Systemic). DMPA has been investigated for the...
DB11796FostemsavirFostemsavir has been investigated for the basic science of Hepatic Impairment.
DB11920LesogaberanLesogaberan has been used in trials studying the treatment and basic science of GERD, Reflux, Heartburn, Regurgitation, and Reflux Disease, among others.
DB12083MafosfamideMafosfamide has been used in trials studying the treatment of Lymphoma, Leukemia, Meningeal Neoplasm, and Brain and Central Nervous System Tumors.
DB12151BrincidofovirBrincidofovir is under investigation for the prevention of Outcomes, Survival Rates, and Cytomegalovirus Disease. Brincidofovir has been investigated for the prevention and treatment of CMV, Adenovirus, BK Virus (BKV), Adenoviruses...
DB12231TemefosDiphos has been used in trials studying the treatment of Plasmodium Falciparum Malaria.
DB12276ApomineApomine has been used in trials studying the treatment of Osteoporosis and Unspecified Adult Solid Tumor, Protocol Specific.
DB12365PerzinfotelPerzinfotel has been used in trials studying the treatment of Diabetes Mellitus and Diabetic Neuropathy, Painful.
DB12393FanapanelFanapanel has been investigated for the treatment of Visual Acuity.
DB12727PerfosfamidePerfosfamide has been used in trials studying the treatment of Lymphoma, Neuroblastoma, and Multiple Myeloma and Plasma Cell Neoplasm.
DB12876GS-9256GS-9256 has been used in trials studying the treatment of HCV Infection and Chronic Hepatitis C Infection.
DB12902TrofosfamideTrofosfamide has been used in trials studying the treatment of Ependymomas, Medulloblastomas, Sarcoma, Soft Tissue, Supratentorial PNETs, and Recurrent Brain Tumors.
DB13495ParaoxonNot Annotated
DB13868AdefovirNot Annotated
DB14126TenofovirTenofovir has been shown to be effective against HIV, herpes simplex virus-2, and hepatitis B virus. To know more about the specific product indications, please visit the information in the...
DB14159Oxidronic acidNot Annotated
DB14207FosinoprilatFosinoprilat is the active phosphinic acid metabolite of prodrug fosinopril, which is activated by esterases in vivo. It binds zinc with phosphinic acid group.
DB06111AB192Investigated for use/treatment in diabetes mellitus type 2.
DB02465Methoxy arachidonyl fluorophosphonateMethoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases. It inhibits phospholipase A2 and fatty acid...
DB14925Tenofovir exalidexTenofovir exalidex is under investigation in clinical trial NCT01080820 (A Safety, Tolerability and Pharmacokinetic Study of a Single Dose of CMX157 in Healthy Volunteers).
DB14972MethamidophosMethamidophos is under investigation in clinical trial NCT03223753 (Web-Based Physical Activity Intervention in Improving Long Term Health in Children and Adolescents With Newly Diagnosed Acute Lymphoblastic Leukemia in First Remission).
DB15163SelatogrelSelatogrel is under investigation in clinical trial NCT03814200 (A Study to Investigate the Effect of Rifampicin on the Uptake and Breakdown of ACT-246475 in Healthy Subjects).
DB09139Technetium Tc-99m oxidronateTechnetium Tc-99m oxidronate is indicated in adult and pediatric patients to be used in skeletal imaging for diagnosis of areas that can present altered osteogenesis. When administered intravenously, it is...
DB12198FosdagrocoratFosdagrocorat has been used in trials studying the treatment and basic science of Rheumatoid Arthritis.
DrugDrug NameTargetType
DB00282Pamidronic acidFarnesyl pyrophosphate synthasetarget
DB00282Pamidronic acidHydroxylapatitetarget
DB00300Tenofovir disoproxilReverse transcriptase/RNaseHtarget
DB00300Tenofovir disoproxilSolute carrier family 22 member 6transporter
DB00300Tenofovir disoproxilSolute carrier family 22 member 8transporter
DB00300Tenofovir disoproxilMultidrug resistance-associated protein 7transporter
DB00300Tenofovir disoproxilMultidrug resistance-associated protein 4transporter
DB00300Tenofovir disoproxilCanalicular multispecific organic anion transporter 1transporter
DB00300Tenofovir disoproxilAdenylate kinase 2, mitochondrialenzyme
DB00300Tenofovir disoproxilAdenylate kinase 4, mitochondrialenzyme
DB00300Tenofovir disoproxilP-glycoprotein 1transporter
DB00300Tenofovir disoproxilNucleoside diphosphokinaseenzyme
DB00300Tenofovir disoproxilCreatine Kinasesenzyme
DB00300Tenofovir disoproxilDNA polymerase/reverse transcriptasetarget
DB00369CidofovirDNA polymerase catalytic subunittarget
DB00369CidofovirSolute carrier family 22 member 6transporter
DB00369CidofovirThymidine phosphorylaseenzyme
DB00399Zoledronic acidFarnesyl pyrophosphate synthasetarget
DB00399Zoledronic acidGeranylgeranyl pyrophosphate synthasetarget
DB00399Zoledronic acidHydroxylapatitetarget
DB00399Zoledronic acidMultidrug resistance-associated protein 1transporter
DB00492FosinoprilAngiotensin-converting enzymetarget
DB00492FosinoprilSolute carrier family 15 member 1transporter
DB00492FosinoprilSolute carrier family 15 member 2transporter
DB00529FoscarnetDNA polymerase catalytic subunittarget
DB00529FoscarnetDNA polymerase catalytic subunittarget
DB00529FoscarnetSolute carrier family 22 member 6transporter
DB00529FoscarnetMonocarboxylate transporter 1transporter
DB00531CyclophosphamideDNAtarget
DB00531CyclophosphamideCytochrome P450 2B6enzyme
DB00531CyclophosphamideCytochrome P450 2C9enzyme
DB00531CyclophosphamideCytochrome P450 3A4enzyme
DB00531CyclophosphamideCytochrome P450 2C19enzyme
DB00531CyclophosphamideCytochrome P450 2A6enzyme
DB00531CyclophosphamideCytochrome P450 2C18enzyme
DB00531CyclophosphamideCytochrome P450 2C8enzyme
DB00531CyclophosphamideCytochrome P450 3A5enzyme
DB00531CyclophosphamideNuclear receptor subfamily 1 group I member 2target
DB00630Alendronic acidFarnesyl pyrophosphate synthasetarget
DB00630Alendronic acidTyrosine-protein phosphatase non-receptor type 4target
DB00630Alendronic acidReceptor-type tyrosine-protein phosphatase Starget
DB00630Alendronic acidReceptor-type tyrosine-protein phosphatase epsilontarget
DB00630Alendronic acidV-type proton ATPase catalytic subunit Atarget
DB00630Alendronic acidHydroxylapatitetarget
DB00677IsoflurophateCholinesterasetarget
DB00677IsoflurophateAcetylcholinesterasetarget
DB00677IsoflurophateCholinesteraseenzyme
DB00677IsoflurophateSerum albumincarrier
DB00677IsoflurophateSerotransferrintarget
DB00710IbandronateFarnesyl pyrophosphate synthasetarget
DB00710IbandronateHydroxylapatitetarget
DB00718Adefovir dipivoxilDNA polymerase/reverse transcriptasetarget
DB00718Adefovir dipivoxilSolute carrier family 22 member 6transporter
DB00718Adefovir dipivoxilMultidrug resistance-associated protein 4transporter
DB00718Adefovir dipivoxilMultidrug resistance-associated protein 5transporter
DB00718Adefovir dipivoxilSolute carrier family 22 member 3transporter
DB00718Adefovir dipivoxilAdenylate kinase 2, mitochondrialenzyme
DB00718Adefovir dipivoxilAdenylate kinase 4, mitochondrialenzyme
DB00718Adefovir dipivoxilNucleoside diphosphate kinase Aenzyme
DB00718Adefovir dipivoxilNucleoside diphosphate kinase Benzyme
DB00720Clodronic acidADP/ATP translocase 2target
DB00720Clodronic acidADP/ATP translocase 1target
DB00720Clodronic acidADP/ATP translocase 3target
DB00720Clodronic acidHydroxylapatitetarget
DB00720Clodronic acidProstaglandin G/H synthase 2enzyme
DB00772MalathionCholinesterasetarget
DB00772MalathionCytochrome P450 1A2enzyme
DB00772MalathionCytochrome P450 2B6enzyme
DB00828FosfomycinUDP-N-acetylglucosamine 1-carboxyvinyltransferasetarget
DB00884Risedronic acidFarnesyl pyrophosphate synthasetarget
DB00884Risedronic acidHydroxylapatitetarget
DB00884Risedronic acidProstaglandin G/H synthase 2enzyme
DB01057EchothiophateCholinesterasetarget
DB01057EchothiophateSerum albumincarrier
DB01077Etidronic acidHydroxylapatitetarget
DB01077Etidronic acidReceptor-type tyrosine-protein phosphatase Starget
DB01077Etidronic acidV-type proton ATPase catalytic subunit Atarget
DB01077Etidronic acidAdenosine triphosphate (ATP)target
DB01133Tiludronic acidTyrosine-protein phosphatase non-receptor type 1target
DB01133Tiludronic acidV-type proton ATPase catalytic subunit Atarget
DB01133Tiludronic acidHydroxylapatitetarget
DB01133Tiludronic acidAdenosine triphosphate (ATP)target
DB01143AmifostineEctonucleotide pyrophosphatase/phosphodiesterase family member 1target
DB01143AmifostineAlkaline phosphatase, placental-liketarget
DB01143AmifostineAlkaline phosphatase, tissue-nonspecific isozymeenzyme
DB01181IfosfamideCytochrome P450 2B6enzyme
DB01181IfosfamideDNAtarget
DB01181IfosfamideCytochrome P450 3A4enzyme
DB01181IfosfamideCytochrome P450 3A5enzyme
DB01181IfosfamideCytochrome P450 2C9enzyme
DB01181IfosfamideCytochrome P450 2C8enzyme
DB01181IfosfamideCytochrome P450 2A6enzyme
DB01181IfosfamideCytochrome P450 2C19enzyme
DB01181IfosfamideCytochrome P450 2C18enzyme
DB01181IfosfamideProstaglandin G/H synthase 1enzyme
DB01181IfosfamideNuclear receptor subfamily 1 group I member 2target
DB01319FosamprenavirHuman immunodeficiency virus type 1 proteasetarget
DB01319FosamprenavirCytochrome P450 3A4enzyme
DB02138Diethyl 4-MethylbenzylphosphonateParathion hydrolasetarget
DB02138Diethyl 4-MethylbenzylphosphonateParathion hydrolasetarget
DB023472-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic AcidGlutamate receptor 2target
DB02386Leucine Phosphonic AcidBacterial leucyl aminopeptidasetarget
DB02386Leucine Phosphonic AcidCytosol aminopeptidasetarget
DB02607Adenosine Phosphonoacetic AcidNucleoside diphosphate kinase Atarget
DB02823Phosphonoacetic AcidAlkaline phosphatasetarget
DB02845Methylphosphinic AcidEsterasetarget
DB02845Methylphosphinic AcidCholinesterasetarget
DB02845Methylphosphinic AcidAcetylcholinesterasetarget
DB02845Methylphosphinic AcidCholinesteraseenzyme
DB02948Fosmidomycin1-deoxy-D-xylulose 5-phosphate reductoisomerasetarget
DB03298PhenylphosphateProto-oncogene tyrosine-protein kinase Srctarget
DB03347Triethyl PhosphateParathion hydrolasetarget
DB03347Triethyl PhosphateParathion hydrolasetarget
DB03347Triethyl PhosphateCellular tumor antigen p53target
DB03459Sparfosic acidAspartate carbamoyltransferase catalytic chaintarget
DB03459Sparfosic acidCAD proteintarget
DB04572ThiotepaCytochrome P450 2B6enzyme
DB04572ThiotepaCytochrome P450 3A4enzyme
DB04572ThiotepaDNAtarget
DB04572ThiotepaCholinesteraseenzyme
DB04695Farnesyl thiopyrophosphateDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)target
DB04695Farnesyl thiopyrophosphateGeranylgeranyl pyrophosphate synthasetarget
DB04695Farnesyl thiopyrophosphateMevalonate kinasetarget
DB04695Farnesyl thiopyrophosphateDehydrosqualene synthasetarget
DB05192MB07811Thyroid hormone receptor betatarget
DB05404AZD 3355Cellular tumor antigen p53target
DB05518Managlinat dialanetilFructose-1,6-bisphosphatase 1target
DB05668PalifosfamideDNA (cytosine-5)-methyltransferase 1target
DB06548Minodronic acidFarnesyl pyrophosphate synthasetarget
DB06548Minodronic acidGeranylgeranyl pyrophosphate synthasetarget
DB07641Decyl(dimethyl)phosphine oxideAmine oxidase [flavin-containing] Atarget
DB07780Farnesyl diphosphateProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphatarget
DB07780Farnesyl diphosphateProtein farnesyltransferase subunit betatarget
DB07780Farnesyl diphosphateGTPase KRastarget
DB07780Farnesyl diphosphate2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthasetarget
DB07780Farnesyl diphosphateFarnesyl pyrophosphate synthasetarget
DB07780Farnesyl diphosphateDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)target
DB07780Farnesyl diphosphateLantibiotic nisin-Ztarget
DB07780Farnesyl diphosphateGeranylgeranyl pyrophosphate synthasetarget
DB07780Farnesyl diphosphate(2Z,6E)-farnesyl diphosphate synthasetarget
DB07780Farnesyl diphosphateGeranylgeranyl transferase type-2 subunit alphatarget
DB07780Farnesyl diphosphateGeranylgeranyl transferase type-2 subunit betatarget
DB07841Geranylgeranyl diphosphateProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphatarget
DB07841Geranylgeranyl diphosphateGeranylgeranyl transferase type-1 subunit betatarget
DB07841Geranylgeranyl diphosphateProtein farnesyltransferase subunit betatarget
DB07841Geranylgeranyl diphosphateGeranylgeranyl pyrophosphate synthasetarget
DB07841Geranylgeranyl diphosphateFarnesyl pyrophosphate synthasetarget
DB07841Geranylgeranyl diphosphateGeranylgeranyl transferase type-2 subunit alphatarget
DB07841Geranylgeranyl diphosphateGeranylgeranyl transferase type-2 subunit betatarget
DB07895ALPHA-HYDROXYFARNESYLPHOSPHONIC ACIDProtein farnesyltransferase subunit betatarget
DB07895ALPHA-HYDROXYFARNESYLPHOSPHONIC ACIDProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphatarget
DB11397DichlorvosSerum albumincarrier
DB11397DichlorvosSerotransferrintarget
DB11397DichlorvosCholinesterasetarget
DB13868AdefovirDNA polymerase/reverse transcriptasetarget
DB14126TenofovirP-glycoprotein 1transporter
DB14126TenofovirSolute carrier family 22 member 6transporter
DB14126TenofovirSolute carrier family 22 member 8transporter
DB14126TenofovirMultidrug resistance-associated protein 4transporter
DB14126TenofovirCytochrome P450 3A4enzyme
DB14126TenofovirNucleoside diphosphate kinase Aenzyme
DB14126TenofovirNucleoside diphosphate kinase Benzyme
DB14126TenofovirAdenylate kinase isoenzyme 1enzyme
DB14126TenofovirAdenylate kinase 2, mitochondrialenzyme
DB14126TenofovirReverse transcriptase/RNaseHtarget
DB14126TenofovirReverse transcriptasetarget
DB14126TenofovirDNA polymerasetarget
DB14126TenofovirSerum albumincarrier
DB06111AB192Myeloperoxidaseenzyme
DB02465Methoxy arachidonyl fluorophosphonateFatty-acid amide hydrolase 1target
DB09139Technetium Tc-99m oxidronateSerum albumincarrier