Organophosphorus Compounds

Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.
DrugDrug NameDrug Indication
DB00282Pamidronic acidFor the treatment of moderate or severe hypercalcemia associated with malignancy
DB00300Tenofovir disoproxilTenofovir is indicated in combination with other antiretroviral agents for the management of HIV-1 infection in adults and pediatric patients 2 years of age and older. It is also indicated for the treatment of chronic hepatitis B in adults and pediatric patients 12 years of age and older [FDA label]. This drug is also a component of multiple products used for the management of HIV-1 infection [F3418], [F3421]. Safety and effectiveness of tenofovir disoproxil in pediatric patients younger than 2 years of age has not been established to this date [FDA label].
DB00369CidofovirFor the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS)
DB00399Zoledronic acidFor the treatment of hypercalcemia of malignancy. Also for the treatment of patients with multiple myeloma and patients with documented bone metastases from solid tumors, in conjunction with standard antineoplastic therapy. In May of 2007, the drug was approved for treatment of Paget’s Disease.
DB00492FosinoprilFor treating mild to moderate hypertension, use as an adjunct in treating congestive heart failure, and may be used to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
DB00529FoscarnetFor the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.
DB00531CyclophosphamideCyclophosphamide is indicated for the treatment of malignant lymphomas, multiple myeloma, leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma, and carcinoma of the breast. It is also indicated for the treatment of biopsy-proven minimal change nephrotic syndrome in pediatric patients.
DB00630Alendronic acidAlendronic acid is indicated for the treatment and prevention of osteoporosis in men and postmenopausal women, treatment of glucocorticoid-induced osteoporosis, and Paget's disease of bone[FDA Label][A959,A176750]. However, alendronic acid is not indicated for use in pediatric populations or patients with a creatinine clearance <35mL/min[FDA Label].
DB00677IsoflurophateFor use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia.
DB00710IbandronateFor the treatment and prevention of osteoporosis in postmenopausal women.
DB00718Adefovir dipivoxilIndicated for the treatment of chronic hepatitis B in adult patients with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease; this is based on histological, virological, biochemical, and serological responses in adult patients with HBeAg+ and HBeAg- chronic hepatitis B with compensated liver function, and in adult patients with clinical evidence of lamivudine-resistant hepatitis B virus with either compensated or decompensated liver function.
DB00720Clodronic acidFor the management of hypercalcemia of malignancy and as an adjunct in the management of osteolysis resulting from bone metastases of malignant tumors.
DB00772MalathionFor patients infected with Pediculus humanus capitis (head lice and their ova) of the scalp hair.
DB00828FosfomycinFor the treatment of uncomplicated urinary tract infections (acute cystitis) in women due to susceptible strains of Escherichia coli and Enterococcus faecalis.
DB00884Risedronic acidRisedronic acid is indicated for the treatment of osteoperosis in men, treatment of Paget's disease, treatment and prevention of osteoperosis in postmenopausal women, and treatment and prevention of glucocorticoid-induced osteoperosis[FDA Label].
DB01057EchothiophateFor use in the treatment of subacute or chronic angle-closure glaucoma after iridectomy or where surgery is refused or contraindicated.
DB01077Etidronic acidFor the treatment of symptomatic Paget's disease of bone and in the prevention and treatment of heterotopic ossification following total hip replacement or due to spinal cord injury.
DB01133Tiludronic acidFor treatment of Paget's disease of bone (osteitis deformans).
DB01143AmifostineFor reduction in the cumulative renal toxicity in patients with ovarian cancer (using cisplatin) and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.
DB01181IfosfamideUsed as a component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer. Also used as a component of various chemotherapeutic regimens for the treatment of cervical cancer, as well as in conjunction with surgery and/or radiation therapy in the treatment of various soft tissue sarcomas. Other indications include treatment of osteosarcoma, bladder cancer, ovarian cancer. small cell lung cancer, and non-Hodgkin's lymphoma.
DB01319FosamprenavirIndicated in combination with other antiretroviral agents for the treatment of human immunodeficiency virus (HIV-1) infection, as well as postexposure prophylaxis of HIV infection in individuals who have had occupational or nonoccupational exposure to potentially infectious body fluids of a person known to be infected with HIV when that exposure represents a substantial risk for HIV transmission. The use of fosamprenavir is pending revision due to a potential association between the drug and myocardial infarction and dyslipidemia in HIV infected adults.
DB02138Diethyl 4-MethylbenzylphosphonateNot Available
DB023472-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic AcidNot Available
DB02386Leucine Phosphonic AcidNot Available
DB02607Adenosine Phosphonoacetic AcidNot Available
DB02823Phosphonoacetic AcidNot Available
DB02845Methylphosphinic AcidNot Available
DB02948FosmidomycinNot Available
DB03298PhenylphosphateNot Available
DB03347Triethyl PhosphateNot Available
DB03459Sparfosic acidNot Available
DB04572ThiotepaThioTEPA is used a as conditioning treatment prior to allogeneic or autologous haematopoietic progenitor cell transplantation (HPCT) in haematological diseases in adult and paediatric patients. Also, when high dose chemotherapy with HPCT support it is appropriate for the treatment of solid tumours in adult and paediatric patients.
DB04695Farnesyl thiopyrophosphateNot Available
DB05192MB07811Investigated for use/treatment in hyperlipidemia.
DB05404AZD 3355Investigated for use/treatment in gastroesophageal reflux disease (GERD).
DB05518Managlinat dialanetilInvestigated for use/treatment in diabetes mellitus type 2.
DB05668PalifosfamideInvestigated for use/treatment in cancer/tumors (unspecified), lymphoma (unspecified), and sarcoma.
DB06091EvofosfamideInvestigated for use/treatment in solid tumors.
DB06166FosdevirineInvestigated for use/treatment in HIV infection and acquired immune deficiency syndrome (AIDS) and aids-related infections.
DB06177GlufosfamideInvestigated for use/treatment in pancreatic cancer, solid tumors, breast cancer, colorectal cancer, brain cancer, lung cancer, ovarian cancer, and sarcoma.
DB06255Incadronic acidFor the treatment of hypercalcemia associated with malignant disease.
DB06548Minodronic acidInvestigated for use/treatment in multiple myeloma, breast cancer, osteoporosis, and lung cancer.
DB06753TriclofosNot Available
DB07641Decyl(dimethyl)phosphine oxideNot Available
DB07780Farnesyl diphosphateNot Available
DB07841Geranylgeranyl diphosphateNot Available
DB09042Tedizolid phosphateTedizolid Phosphate is an oxazolidinone antibacterial drug indicated in adults for the treatment of acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible isolates of the following Gram-positive microorganisms: Staphylococcus aureus (including methicillin-resistant [MRSA] and methicillin-susceptible [MSSA] isolates), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus anginosus Group (including Streptococcus anginosus, Streptococcus intermedius, and Streptococcus constellatus), and Enterococcus faecalis.
DB09138Technetium Tc-99m medronateTechnetium Tc 99m Medronate is indicated for use as a bone imaging agent to delineate areas of altered osteogenesis.
DB11379ButonateNot Available
DB11390CoumaphosNot Available
DB11392CythioateNot Available
DB11397DichlorvosNot Available
DB11408FamphurNot Available
DB11412FenthionNot Available
DB11448PhosmetNot Available
DB11456RonnelNot Available
DB11473MetrifonateNot Available
DB11620Neridronic AcidNot Available
DB11747BarasertibNot Available
DB11768ZytronNot Available
DB11796FostemsavirNot Available
DB11920LesogaberanNot Available
DB12083MafosfamideNot Available
DB12151BrincidofovirNot Available
DB12231TemefosNot Available
DB12276ApomineNot Available
DB12365PerzinfotelNot Available
DB12393FanapanelNot Available
DB12727PerfosfamideNot Available
DB12876GS-9256Not Available
DB12902TrofosfamideNot Available
DB13495ParaoxonNot Available
DB13868AdefovirNot Available
DB14126TenofovirTenofovir has been shown to be effective against HIV, herpes simplex virus-2, and hepatitis B virus.[A178330] To know more about the specific product indications, please visit the information in the orally available forms of tenofovir, [tenofovir alafenamide] and [tenofovir disoproxil].
DB14159Oxidronic acidNot Available
DB14207FosinoprilatNot Available
DB06111AB192Investigated for use/treatment in diabetes mellitus type 2.
DB02465Methoxy arachidonyl fluorophosphonateNot Available
DB14925Tenofovir exalidexNot Available
DB14972MethamidophosNot Available
DB15163SelatogrelNot Available
DB09139Technetium Tc-99m oxidronateTechnetium Tc-99m oxidronate is indicated in adult and pediatric patients to be used in skeletal imaging for diagnosis of areas that can present altered osteogenesis. When administered intravenously, it is able to generate a clear image of the bones which allows the physician to diagnose any bone problem.[L1141] It is important to point out that this drug has to be manipulated only under the service of a nuclear specialist.[L1140] The approved indications for a bone scan are 1) visualization of tumor metastasis in bone, 2) osteomyelitis, 3) fracture, 4) stress fracture, 5) avascular necrosis, 6) osteoporosis and 7) prosthetic joint evaluation. From all the major indications, the detection of a metastatic disease is the most common because it presents a 95% of sensitivity and lesion detection can be done 6 months earlier than with X-ray studies.[L1139]
DB12198FosdagrocoratNot Available
DrugDrug NameTargetType
DB00282Pamidronic acidFarnesyl pyrophosphate synthasetarget
DB00282Pamidronic acidHydroxylapatitetarget
DB00300Tenofovir disoproxilReverse transcriptase/RNaseHtarget
DB00300Tenofovir disoproxilSolute carrier family 22 member 6transporter
DB00300Tenofovir disoproxilSolute carrier family 22 member 8transporter
DB00300Tenofovir disoproxilMultidrug resistance-associated protein 7transporter
DB00300Tenofovir disoproxilMultidrug resistance-associated protein 4transporter
DB00300Tenofovir disoproxilCanalicular multispecific organic anion transporter 1transporter
DB00300Tenofovir disoproxilAdenylate kinase 2, mitochondrialenzyme
DB00300Tenofovir disoproxilAdenylate kinase 4, mitochondrialenzyme
DB00300Tenofovir disoproxilP-glycoprotein 1transporter
DB00300Tenofovir disoproxilNucleoside diphosphokinaseenzyme
DB00300Tenofovir disoproxilCreatine Kinasesenzyme
DB00300Tenofovir disoproxilDNA polymerase/reverse transcriptasetarget
DB00369CidofovirDNA polymerase catalytic subunittarget
DB00369CidofovirSolute carrier family 22 member 6transporter
DB00369CidofovirThymidine phosphorylaseenzyme
DB00399Zoledronic acidFarnesyl pyrophosphate synthasetarget
DB00399Zoledronic acidGeranylgeranyl pyrophosphate synthasetarget
DB00399Zoledronic acidHydroxylapatitetarget
DB00399Zoledronic acidMultidrug resistance-associated protein 1transporter
DB00492FosinoprilAngiotensin-converting enzymetarget
DB00492FosinoprilSolute carrier family 15 member 1transporter
DB00492FosinoprilSolute carrier family 15 member 2transporter
DB00529FoscarnetDNA polymerase catalytic subunittarget
DB00529FoscarnetDNA polymerase catalytic subunittarget
DB00529FoscarnetSolute carrier family 22 member 6transporter
DB00529FoscarnetMonocarboxylate transporter 1transporter
DB00531CyclophosphamideCytochrome P450 2B6enzyme
DB00531CyclophosphamideCytochrome P450 2C9enzyme
DB00531CyclophosphamideCytochrome P450 3A4enzyme
DB00531CyclophosphamideCytochrome P450 2C19enzyme
DB00531CyclophosphamideCytochrome P450 2A6enzyme
DB00531CyclophosphamideCytochrome P450 2C18enzyme
DB00531CyclophosphamideCytochrome P450 2C8enzyme
DB00531CyclophosphamideCytochrome P450 3A5enzyme
DB00531CyclophosphamideNuclear receptor subfamily 1 group I member 2target
DB00630Alendronic acidFarnesyl pyrophosphate synthasetarget
DB00630Alendronic acidTyrosine-protein phosphatase non-receptor type 4target
DB00630Alendronic acidReceptor-type tyrosine-protein phosphatase Starget
DB00630Alendronic acidReceptor-type tyrosine-protein phosphatase epsilontarget
DB00630Alendronic acidV-type proton ATPase catalytic subunit Atarget
DB00630Alendronic acidHydroxylapatitetarget
DB00677IsoflurophateSerum albumincarrier
DB00710IbandronateFarnesyl pyrophosphate synthasetarget
DB00718Adefovir dipivoxilDNA polymerase/reverse transcriptasetarget
DB00718Adefovir dipivoxilSolute carrier family 22 member 6transporter
DB00718Adefovir dipivoxilMultidrug resistance-associated protein 4transporter
DB00718Adefovir dipivoxilMultidrug resistance-associated protein 5transporter
DB00718Adefovir dipivoxilSolute carrier family 22 member 3transporter
DB00718Adefovir dipivoxilAdenylate kinase 2, mitochondrialenzyme
DB00718Adefovir dipivoxilAdenylate kinase 4, mitochondrialenzyme
DB00718Adefovir dipivoxilNucleoside diphosphate kinase Aenzyme
DB00718Adefovir dipivoxilNucleoside diphosphate kinase Benzyme
DB00720Clodronic acidADP/ATP translocase 2target
DB00720Clodronic acidADP/ATP translocase 1target
DB00720Clodronic acidADP/ATP translocase 3target
DB00720Clodronic acidHydroxylapatitetarget
DB00720Clodronic acidProstaglandin G/H synthase 2enzyme
DB00772MalathionCytochrome P450 1A2enzyme
DB00772MalathionCytochrome P450 2B6enzyme
DB00828FosfomycinUDP-N-acetylglucosamine 1-carboxyvinyltransferasetarget
DB00884Risedronic acidFarnesyl pyrophosphate synthasetarget
DB00884Risedronic acidHydroxylapatitetarget
DB00884Risedronic acidProstaglandin G/H synthase 2enzyme
DB01057EchothiophateSerum albumincarrier
DB01077Etidronic acidHydroxylapatitetarget
DB01077Etidronic acidReceptor-type tyrosine-protein phosphatase Starget
DB01077Etidronic acidV-type proton ATPase catalytic subunit Atarget
DB01077Etidronic acidAdenosine triphosphate (ATP)target
DB01133Tiludronic acidTyrosine-protein phosphatase non-receptor type 1target
DB01133Tiludronic acidV-type proton ATPase catalytic subunit Atarget
DB01133Tiludronic acidHydroxylapatitetarget
DB01133Tiludronic acidAdenosine triphosphate (ATP)target
DB01143AmifostineEctonucleotide pyrophosphatase/phosphodiesterase family member 1target
DB01143AmifostineAlkaline phosphatase, placental-liketarget
DB01143AmifostineAlkaline phosphatase, tissue-nonspecific isozymeenzyme
DB01181IfosfamideCytochrome P450 2B6enzyme
DB01181IfosfamideCytochrome P450 3A4enzyme
DB01181IfosfamideCytochrome P450 3A5enzyme
DB01181IfosfamideCytochrome P450 2C9enzyme
DB01181IfosfamideCytochrome P450 2C8enzyme
DB01181IfosfamideCytochrome P450 2A6enzyme
DB01181IfosfamideCytochrome P450 2C19enzyme
DB01181IfosfamideCytochrome P450 2C18enzyme
DB01181IfosfamideProstaglandin G/H synthase 1enzyme
DB01181IfosfamideNuclear receptor subfamily 1 group I member 2target
DB01319FosamprenavirHuman immunodeficiency virus type 1 proteasetarget
DB01319FosamprenavirCytochrome P450 3A4enzyme
DB02138Diethyl 4-MethylbenzylphosphonateParathion hydrolasetarget
DB02138Diethyl 4-MethylbenzylphosphonateParathion hydrolasetarget
DB023472-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic AcidGlutamate receptor 2target
DB02386Leucine Phosphonic AcidBacterial leucyl aminopeptidasetarget
DB02386Leucine Phosphonic AcidCytosol aminopeptidasetarget
DB02607Adenosine Phosphonoacetic AcidNucleoside diphosphate kinase Atarget
DB02823Phosphonoacetic AcidAlkaline phosphatasetarget
DB02845Methylphosphinic AcidEsterasetarget
DB02845Methylphosphinic AcidCholinesterasetarget
DB02845Methylphosphinic AcidAcetylcholinesterasetarget
DB02845Methylphosphinic AcidCholinesteraseenzyme
DB02948Fosmidomycin1-deoxy-D-xylulose 5-phosphate reductoisomerasetarget
DB03298PhenylphosphateProto-oncogene tyrosine-protein kinase Srctarget
DB03347Triethyl PhosphateParathion hydrolasetarget
DB03347Triethyl PhosphateParathion hydrolasetarget
DB03347Triethyl PhosphateCellular tumor antigen p53target
DB03459Sparfosic acidAspartate carbamoyltransferase catalytic chaintarget
DB03459Sparfosic acidCAD proteintarget
DB04572ThiotepaCytochrome P450 2B6enzyme
DB04572ThiotepaCytochrome P450 3A4enzyme
DB04695Farnesyl thiopyrophosphateDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)target
DB04695Farnesyl thiopyrophosphateGeranylgeranyl pyrophosphate synthasetarget
DB04695Farnesyl thiopyrophosphateMevalonate kinasetarget
DB04695Farnesyl thiopyrophosphateDehydrosqualene synthasetarget
DB05192MB07811Thyroid hormone receptor betatarget
DB05404AZD 3355Cellular tumor antigen p53target
DB05518Managlinat dialanetilFructose-1,6-bisphosphatase 1target
DB05668PalifosfamideDNA (cytosine-5)-methyltransferase 1target
DB06548Minodronic acidFarnesyl pyrophosphate synthasetarget
DB06548Minodronic acidGeranylgeranyl pyrophosphate synthasetarget
DB07641Decyl(dimethyl)phosphine oxideAmine oxidase [flavin-containing] Atarget
DB07780Farnesyl diphosphateProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphatarget
DB07780Farnesyl diphosphateProtein farnesyltransferase subunit betatarget
DB07780Farnesyl diphosphateGTPase KRastarget
DB07780Farnesyl diphosphate2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthasetarget
DB07780Farnesyl diphosphateFarnesyl pyrophosphate synthasetarget
DB07780Farnesyl diphosphateDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)target
DB07780Farnesyl diphosphateLantibiotic nisin-Ztarget
DB07780Farnesyl diphosphateGeranylgeranyl pyrophosphate synthasetarget
DB07780Farnesyl diphosphate(2Z,6E)-farnesyl diphosphate synthasetarget
DB07780Farnesyl diphosphateGeranylgeranyl transferase type-2 subunit alphatarget
DB07780Farnesyl diphosphateGeranylgeranyl transferase type-2 subunit betatarget
DB07841Geranylgeranyl diphosphateProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphatarget
DB07841Geranylgeranyl diphosphateGeranylgeranyl transferase type-1 subunit betatarget
DB07841Geranylgeranyl diphosphateProtein farnesyltransferase subunit betatarget
DB07841Geranylgeranyl diphosphateGeranylgeranyl pyrophosphate synthasetarget
DB07841Geranylgeranyl diphosphateFarnesyl pyrophosphate synthasetarget
DB07841Geranylgeranyl diphosphateGeranylgeranyl transferase type-2 subunit alphatarget
DB07841Geranylgeranyl diphosphateGeranylgeranyl transferase type-2 subunit betatarget
DB07895ALPHA-HYDROXYFARNESYLPHOSPHONIC ACIDProtein farnesyltransferase subunit betatarget
DB07895ALPHA-HYDROXYFARNESYLPHOSPHONIC ACIDProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphatarget
DB11397DichlorvosSerum albumincarrier
DB13868AdefovirDNA polymerase/reverse transcriptasetarget
DB14126TenofovirP-glycoprotein 1transporter
DB14126TenofovirSolute carrier family 22 member 6transporter
DB14126TenofovirSolute carrier family 22 member 8transporter
DB14126TenofovirMultidrug resistance-associated protein 4transporter
DB14126TenofovirCytochrome P450 3A4enzyme
DB14126TenofovirNucleoside diphosphate kinase Aenzyme
DB14126TenofovirNucleoside diphosphate kinase Benzyme
DB14126TenofovirAdenylate kinase isoenzyme 1enzyme
DB14126TenofovirAdenylate kinase 2, mitochondrialenzyme
DB14126TenofovirReverse transcriptase/RNaseHtarget
DB14126TenofovirReverse transcriptasetarget
DB14126TenofovirDNA polymerasetarget
DB14126TenofovirSerum albumincarrier
DB02465Methoxy arachidonyl fluorophosphonateFatty-acid amide hydrolase 1target
DB09139Technetium Tc-99m oxidronateSerum albumincarrier