Organometallic Compounds

Name
Organometallic Compounds
Accession Number
DBCAT000755
Description

A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)

Drugs
DrugDrug Description
Technetium Tc-99m arcitumomabFor imaging colorectal tumors
GadodiamideA gadolinium-based contrast agent used for the visualization of lesions with vascularity during magnetic resonance imaging (MRI) scans.
NitroprussideA direct acting vasodilator used to treat hypertension, to induce controlled hypotension to reduce postoperative bleeding, and to manage acute heart failure.
OxaliplatinA platinum based chemotherapy agent used to treat carcinoma of the colon or rectum or stage III colon cancer.
ChlormerodrinPreviously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool.
Gadopentetic acidA gadolinium compound used as a contrast agent in MRIs.
Iron DextranAn iron supplement used to treat iron deficiency in patients who cannot take oral iron.
CarboplatinA alkylating agent used to treat advanced ovarian cancer.
AuranofinAn antirheumatic used to treat active, progressive, or destructive forms of inflammatory arthritis.
Arsenic trioxideA chemotherapeutic agent used in the treatment of refractory or relapsed acute promyelocytic leukemia in patients with prior retinoid and anthracycline chemotherapy.
IronAn essential element commonly used for the treatment of patients with documented iron deficiency.
Arsanilic acidAn arsenical which has been used as a feed additive for enteric conditions in pigs and poultry. It causes blindness and is ototoxic and nephrotoxic in animals. [PubChem]
PicoplatinFor the treatment of patients with solid tumors.
AP5346For the treatment of various forms of cancer.
SatraplatinInvestigated for use/treatment in lung cancer, prostate cancer, and solid tumors.
AP5280Investigated for use/treatment in solid tumors.
Technetium Tc-99m ciprofloxacinInvestigated for use/treatment in infectious and parasitic disease (unspecified).
Sodium stibogluconateFor the treatment of various types of a protozoal infection called leishmaniasis, which may result from sandfly bites in tropical and temperate parts of the world. Also investigated for use/treatment...
DarinaparsinInvestigated for use/treatment in blood (blood forming organ disorders, unspecified), cancer/tumors (unspecified), solid tumors, multiple myeloma, and liver cancer.
FerumoxytolAn intravenous iron replacement product used to treat iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD), or in patients who are unable to tolerate or who have not responded adequately to oral iron supplementation.
Prussian blueA chelating agent used to reduce the extent of systemic contamination with radioactive cesium and/or radioactive or non-radioactive thallium.
Bamet-UD2Bamet-UD2 is a novel bile acid-platinum derivative.
cis-Diamminechlorocholylglycinateplatinum(II)Not Annotated
Gadoxetic acidA gadolinium-based contrast agent used in magnetic resonance imaging (MRI) to help characterize lesions in the liver.
Ferric carboxymaltoseAn iron replacement therapy used to treat iron deficiency anemia in adults with intolerance or inadequate clinical response to oral iron or those who have non-dialysis dependent chronic kidney disease.
ArsthinolAntiprotozoal agent effective against amoebiasis and yaws.
AurothioglucoseA gold compound used in the treatment of rheumatoid arthritis.
Technetium Tc-99m mebrofeninA diagnostic radiopharmaceutical agent used during hepatobiliary imaging tests.
Technetium Tc-99m medronateA diagnostic radiopharmaceutical agent used as a bone imaging agent to delineate areas of altered osteogenesis.
Iron sucroseAn compound used as a source of iron in patients with iron deficiency anemia associated with chronic kidney disease (CKD).
Technetium Tc-99m sestamibiA radiopharmaceutical diagnostic agent used in nuclear medicine imaging tests to detect coronary artery disease and evaluate myocardial function.
Technetium Tc-99m exametazimeA radiopharmaceutical diagnostic agent used as an adjunct for scintigraphy in the detection of altered regional cerebral perfusion in stroke.
Technetium Tc-99m disofeninA radiopharmaceutical diagnostic agent used for hepatobiliary scans.
Sodium aurothiomalateA disease-modifying antirheumatic drug (DMARD) indicated for the symptomatic treatment of arthritis.
MersalylElevated blood pressure, edema [L1577, L1585].
Ferric ammonium citrateNot Annotated
FerumoxsilNot Annotated
FerumoxidesNot Annotated
Ferric sulfateA medication used as a coagulant and hemostatic agent.
Ferrous bisglycinateFerrous bisglycinate is a chelate that is used as a source of dietary iron. Forming a ring structure when reacting with glycine, ferrous bisglycinate acts as both a chelate and...
CarbarsoneCarbarsone is a compound used as an antiprotozoal drug for the treatment of histomoniasis (or blackhead disease) in addition to other infectious diseases in chicken and turkeys. It belongs to...
GleptoferronColloid solution of ferric hydroxide, dextran & glucoheptonic acid.
NitarsoneNitarsone is an organoarsenic compound. It is used as an additive in poultry feed to improve weight gain and feed efficiency, while preventing blackhead disease. It is marketed as Histostat...
RoxarsoneRoxarsone is an organoarsenic molecule added to poultry feed. The addition of this compound to poultry feed improves weight gain and feed efficiency as well as prevent the growth of...
Ferric oxideAn ingredient used in a number of skin protecting products.
ThimerosalUsed as preservative in some cosmetics, topical pharmaceuticals, and biological drug products, which includes vaccines [L1671, L1672, L1673].
Iron isomaltoside 1000Iron isomaltoside 1000 is under investigation in Iron Deficiency Anaemia. Iron isomaltoside 1000 has been investigated for the treatment and basic science of Anemia, Gastric Cancer, Esophageal Cancer, Chronic Kidney...
PerflubutanePerflubutane has been used in trials studying the diagnostic of Liver Mass, Liver Diseases, Liver Metastasis, Portal Hypertension, and Peripheral Artery Disease. It is a cardiovascular drug designed to enable...
MelarsoprolMelarsoprol is under investigation in clinical trial NCT00330148 (Randomized Clinical Trial of Three Drug Combinations for Late-Stage Gambiense Human African Trypanosomiasis).
LobaplatinLobaplatin has been used in trials studying the treatment of Breast Cancer, Hepatocellular Carcinoma, and Lobaplatin and Gemcitabine in Combination, Second-line Treatments on Advanced Osteosarcoma.
NedaplatinUsed in the treatment of non-small cell lung cancer, small cell lung cancer, oesophygeal cancer, and head and neck cancers .
Ferrous sulfate anhydrousAn iron supplement used to prevent or treat iron deficiency anemia.
AcetarsolAn anti infective used to treat a wide variety of infections in the body.
Sodium feredetateNot Annotated
MerbrominMercurochrome is a trade name of merbromin commonly used as a topical first-aid antiseptic agent. It is an organomercuric disodium salt compound and a fluorescein that is available in many...
Ferric hydroxideNot Annotated
Ferrous chlorideNot Annotated
AurotioprolNot Annotated
Ferric subsulfateFerric subsulfate is a stypic or hemostatic agent that causes agglutination of surface proteins resulting in local hemostasis. It has the chemical formula Fe4(OH)2(SO4)5. It is used after superficial skin...
Lutetium Lu 177 dotatateA radiolabeled somatostatin analog used to treat somatostatin receptor positive gastroenteropancreatic neuroendocrine tumors.
Thiosalicylic acidNot Annotated
Ferrous gluconateA medication used to treat iron-deficiency anemia.
Ferrous succinateUsed in preventing and treating iron-deficiency anemia.
Ferrous fumarateA medication used to treat iron-deficiency anemia.
Tetraferric tricitrate decahydrateA phosphate binder used to control serum phosphorus levels or as an iron supplement.
Ferric oxyhydroxideAn ingredient used to treat hyperphosphatemia in patients with renal failure or patients on dialysis.
Cacodylic acidNot Available
Arsenous acidNot Available
SucralfateA gastro-duodenal protective agent used in the treatment of gastric and duodenal ulcers and to prevent duodenal ulcer recurrence.
Demplatin pegraglumerDemplatin pegraglumer is under investigation in clinical trial NCT02043288 (Combination Therapy With NC-6004 and Gemcitabine Versus Gemcitabine Alone in Pancreatic Cancer).
Technetium Tc-99m oxidronateTechnetium Tc-99m oxidronate is indicated in adult and pediatric patients to be used in skeletal imaging for diagnosis of areas that can present altered osteogenesis. When administered intravenously, it is...
Technetium Tc-99m tetrofosminTechnetium-99m tetrofosmin is indicated for the diagnosis of heart abnormalities by exercise myocardial scintigraphy. The exercise myocardial scintigraphy is an established method for the diagnosis of the severity of coronary...
Ferric chlorideNot Annotated
p-Hydroxymercuribenzoic acidNot Available
Antimony potassium tartrateAntimony potassium tartrate is a schistosomicide possibly useful against other parasites. It has irritant emetic properties and may cause lethal cardiac toxicity among other adverse effects.
Ferric maltolA complexed iron supplement used to treat iron deficiency in adults.
TributyltinNot Available
Drugs & Drug Targets
DrugTargetType
Technetium Tc-99m arcitumomabCarcinoembryonic antigen-related cell adhesion molecule 1target
NitroprussideAtrial natriuretic peptide receptor 1target
NitroprussideCytochrome P450 1A1enzyme
OxaliplatinDNAtarget
OxaliplatinSolute carrier family 22 member 2transporter
OxaliplatinHigh affinity copper uptake protein 1transporter
OxaliplatinSolute carrier family 22 member 3transporter
OxaliplatinATP-binding cassette sub-family G member 2transporter
OxaliplatinGlutathione S-transferase theta-1enzyme
OxaliplatinMetallothionein-1Aenzyme
OxaliplatinMetallothionein-2enzyme
OxaliplatinMyeloperoxidaseenzyme
OxaliplatinSuperoxide dismutase [Cu-Zn]enzyme
OxaliplatinGlutathione S-transferase Penzyme
OxaliplatinGlutathione S-transferase Mu 1enzyme
OxaliplatinNAD(P)H dehydrogenase [quinone] 1enzyme
OxaliplatinCanalicular multispecific organic anion transporter 1transporter
OxaliplatinCopper-transporting ATPase 2transporter
OxaliplatinCopper-transporting ATPase 1transporter
ChlormerodrinSuccinate-semialdehyde dehydrogenase, mitochondrialtarget
ChlormerodrinSolute carrier family 12 member 1target
Gadopentetic acid6-phosphogluconate dehydrogenase, decarboxylatingtarget
Iron DextranHemoglobin subunit betatarget
Iron DextranHemoglobin subunit alphatarget
Iron DextranFerritin heavy chaintarget
Iron DextranFerritin light chaintarget
Iron DextranSerotransferrincarrier
CarboplatinDNAtarget
CarboplatinHigh affinity copper uptake protein 1transporter
CarboplatinProbable low affinity copper uptake protein 2transporter
CarboplatinXanthine dehydrogenase/oxidaseenzyme
CarboplatinMyeloperoxidaseenzyme
CarboplatinGlutathione S-transferase theta-1enzyme
CarboplatinMetallothionein-1Aenzyme
CarboplatinMetallothionein-2enzyme
CarboplatinSuperoxide dismutase [Cu-Zn]enzyme
CarboplatinGlutathione S-transferase Penzyme
CarboplatinGlutathione S-transferase Mu 1enzyme
CarboplatinNAD(P)H dehydrogenase [quinone] 1enzyme
CarboplatinCopper-transporting ATPase 1transporter
CarboplatinCopper-transporting ATPase 2transporter
CarboplatinATP-binding cassette sub-family G member 2transporter
CarboplatinCanalicular multispecific organic anion transporter 1transporter
AuranofinInhibitor of nuclear factor kappa-B kinase subunit betatarget
AuranofinSerum albumincarrier
AuranofinPeroxiredoxin-5, mitochondrialtarget
Arsenic trioxideInhibitor of nuclear factor kappa-B kinase subunit betatarget
Arsenic trioxideTranscription factor AP-1target
Arsenic trioxideG1/S-specific cyclin-D1target
Arsenic trioxideMitogen-activated protein kinase 3target
Arsenic trioxideMitogen-activated protein kinase 1target
Arsenic trioxideRAC-alpha serine/threonine-protein kinasetarget
Arsenic trioxideCanalicular multispecific organic anion transporter 1transporter
Arsenic trioxideThioredoxin reductase 1, cytoplasmictarget
Arsenic trioxideP-glycoprotein 1transporter
Arsenic trioxideCytochrome P450 3A4enzyme
Arsenic trioxideCyclin-dependent kinase inhibitor 1target
Arsenic trioxideHistone deacetylase 1target
Arsenic trioxideProtein PMLtarget
Arsenic trioxideSerum albumincarrier
IronTransferrin receptor protein 1target
IronEgl nine homolog 1target
IronHistone deacetylase 8target
IronAlpha-hemoglobin-stabilizing proteintarget
IronHemoglobin subunit alphatarget
IronFrataxin, mitochondrialtarget
IronFerritin heavy chaintarget
IronFlap endonuclease 1target
IronEndonuclease 8-like 1target
IronEndonuclease 8-like 2target
IronDNA polymerase betatarget
IronCeruloplasmintarget
IronSerotransferrintarget
Arsanilic acidLysozyme Ctarget
PicoplatinDNAtarget
AP5346DNAtarget
SatraplatinDNAtarget
Technetium Tc-99m ciprofloxacinDNA gyrase subunit Btarget
Technetium Tc-99m ciprofloxacinDNA topoisomerase 2-betatarget
Technetium Tc-99m ciprofloxacinCytochrome P450 1A2enzyme
Sodium stibogluconateDNA topoisomerase 1target
FerumoxytolSerotransferrintransporter
FerumoxytolFerritin light chaintransporter
FerumoxytolFerritin heavy chaintransporter
Bamet-UD2Solute carrier organic anion transporter family member 1B1transporter
cis-Diamminechlorocholylglycinateplatinum(II)Solute carrier organic anion transporter family member 1B1transporter
Gadoxetic acidSolute carrier organic anion transporter family member 1B1transporter
Gadoxetic acidSolute carrier organic anion transporter family member 1B3transporter
Gadoxetic acidCanalicular multispecific organic anion transporter 2transporter
Gadoxetic acidCanalicular multispecific organic anion transporter 1transporter
Gadoxetic acidMultidrug resistance-associated protein 4transporter
AurothioglucoseAdenylate cyclase type 1target
AurothioglucoseAdenylate cyclase type 2target
AurothioglucoseAdenylate cyclase type 5target
Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B1transporter
Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B3transporter
Technetium Tc-99m sestamibiP-glycoprotein 1transporter
Technetium Tc-99m sestamibiMultidrug resistance-associated protein 1transporter
Sodium aurothiomalateUDP-glucuronosyltransferase 1-1enzyme
MersalylAlkaline phosphatase, tissue-nonspecific isozymetarget
MersalylAquaporin-1target
MersalylMonocarboxylate transporter 1target
MersalylInter-alpha-trypsin inhibitor heavy chain H1enzyme
MersalylPhosphoenolpyruvate carboxykinase, cytosolic [GTP]enzyme
ThimerosalSerum albumincarrier
ThimerosalInositol 1,4,5-trisphosphate receptor type 1transporter
ThimerosalMethionine synthasetarget
ThimerosalCystine/glutamate transportertarget
ThimerosalSodium/potassium-transporting ATPase subunit gammatarget
ThimerosalGlutathione reductase, mitochondrialenzyme
ThimerosalGlutathione peroxidase 1enzyme
ThimerosalSuperoxide dismutase [Mn], mitochondrialenzyme
NedaplatinGlutathionetarget
NedaplatinDNAtarget
Ferrous sulfate anhydrousNatural resistance-associated macrophage protein 2transporter
Ferrous sulfate anhydrousCeruloplasminenzyme
Ferrous sulfate anhydrousHemoglobin subunit alphatarget
Ferrous sulfate anhydrousTransferrin receptortarget
Ferrous sulfate anhydrousSolute carrier family 40 member 1transporter
Ferrous sulfate anhydrousHepcidinenzyme
Ferrous sulfate anhydrousSerotransferrinenzyme
Ferrous sulfate anhydrousHephaestinenzyme
Ferrous sulfate anhydrousCytochrome b reductase 1enzyme
Lutetium Lu 177 dotatateSomatostatin receptor type 2target
Lutetium Lu 177 dotatateSomatostatin receptor type 1target
Lutetium Lu 177 dotatateSomatostatin receptor type 3target
Lutetium Lu 177 dotatateSomatostatin receptor type 4target
Lutetium Lu 177 dotatateSomatostatin receptor type 5target
Ferrous gluconateTransferrin receptor protein 1target
Ferrous gluconateEgl nine homolog 1target
Ferrous gluconateHistone deacetylase 8target
Ferrous gluconateAlpha-hemoglobin-stabilizing proteintarget
Ferrous gluconateHemoglobin subunit alphatarget
Ferrous gluconateFrataxin, mitochondrialtarget
Ferrous gluconateFerritin heavy chaintarget
Ferrous gluconateFlap endonuclease 1target
Ferrous gluconateEndonuclease 8-like 1target
Ferrous gluconateEndonuclease 8-like 2target
Ferrous gluconateDNA polymerase betatarget
Ferrous gluconateCeruloplasmintarget
Ferrous gluconateSerotransferrintarget
Ferrous succinateTransferrin receptor protein 1target
Ferrous succinateEgl nine homolog 1target
Ferrous succinateHistone deacetylase 8target
Ferrous succinateAlpha-hemoglobin-stabilizing proteintarget
Ferrous succinateHemoglobin subunit alphatarget
Ferrous succinateFrataxin, mitochondrialtarget
Ferrous succinateFerritin heavy chaintarget
Ferrous succinateFlap endonuclease 1target
Ferrous succinateEndonuclease 8-like 1target
Ferrous succinateEndonuclease 8-like 2target
Ferrous succinateDNA polymerase betatarget
Ferrous succinateCeruloplasmintarget
Ferrous succinateSerotransferrintarget
Ferrous fumarateTransferrin receptor protein 1target
Ferrous fumarateEgl nine homolog 1target
Ferrous fumarateHistone deacetylase 8target
Ferrous fumarateAlpha-hemoglobin-stabilizing proteintarget
Ferrous fumarateHemoglobin subunit alphatarget
Ferrous fumarateFrataxin, mitochondrialtarget
Ferrous fumarateFerritin heavy chaintarget
Ferrous fumarateFlap endonuclease 1target
Ferrous fumarateEndonuclease 8-like 1target
Ferrous fumarateEndonuclease 8-like 2target
Ferrous fumarateDNA polymerase betatarget
Ferrous fumarateCeruloplasmintarget
Ferrous fumarateSerotransferrintarget
Tetraferric tricitrate decahydrateSerotransferrincarrier
Tetraferric tricitrate decahydrateIron(3+)-hydroxamate-binding protein FhuDtarget
Tetraferric tricitrate decahydrateIntegrin beta-3carrier
Tetraferric tricitrate decahydrateCalreticulincarrier
Tetraferric tricitrate decahydrateTransferrin receptor protein 1target
Cacodylic acidGag-Pol polyproteintarget
Cacodylic acidNitric oxide synthase, endothelialtarget
Cacodylic acidAldose reductasetarget
Cacodylic acidGuanine nucleotide-binding protein G(t) subunit alpha-1target
Arsenous acidArsenate reductasetarget
Arsenous acidArsenical pump-driving ATPasetarget
SucralfateFibrinogentarget
SucralfatePepsin A-5target
SucralfatePro-epidermal growth factortarget
SucralfateFibroblast growth factor 2target
Technetium Tc-99m oxidronateSerum albumincarrier
Technetium Tc-99m tetrofosminP-glycoprotein 1carrier
p-Hydroxymercuribenzoic acidCarbonic anhydrase 2target
Ferric maltolUDP-glucuronosyltransferase 1-6enzyme
Ferric maltolIntegrin beta-3target
Ferric maltolNatural resistance-associated macrophage protein 2target
Ferric maltolNatural resistance-associated macrophage protein 2transporter
Ferric maltolIntegrin beta-3transporter
TributyltinNuclear receptor coactivator 2target
TributyltinRetinoic acid receptor RXR-alphatarget