Organometallic Compounds

A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
DrugDrug NameDrug Indication
DB00113Technetium Tc-99m arcitumomabFor imaging colorectal tumors
DB00225GadodiamideFor intravenous use in MRI to visualize lesions with abnormal vascularity (or those thought to cause abnormalities in the blood-brain barrier) in the brain (intracranial lesions), spine, and associated tissues.
DB00325NitroprussideFor immediate reduction of blood pressure of patients in hypertensive crises, reduce bleeding during surgery, and for the treatment of acute congestive heart failure
DB00526OxaliplatinUsed in combination with infusional 5-FU/LV, is indicated for the treatment of advanced carcinoma of the colon or rectum and for adjuvant treatment of stage III colon cancer patients who have undergone complete resection of the primary tumor.
DB00534ChlormerodrinPreviously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool.
DB00789Gadopentetic acidFor use with magnetic resonance imaging (MRI) in adults, and pediatric patients (2 years of age and older) to visualize lesions with abnormal vascularity in the brain (intracranial lesions), spine and associated tissues as well as lesions with abnormal vascularity in the head and neck. Also used to facilitate the visualization of lesions with abnormal vascularity in the body (excluding the heart).
DB00893Iron DextranFor treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Also used to replenish body iron stores in Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD) patients receiving or not receiving erythropoietin and in Hemodialysis Dependent (HDD-CKD) and Peritoneal Dialysis Dependent (PDD-CKD) - Chronic Kidney Disease patients receiving an erythropoietin.
DB00958CarboplatinFor the initial treatment of advanced ovarian carcinoma in established combination with other approved chemotherapeutic agents. One established combination regimen consists of PARAPLATIN and cyclophosphamide. It is also indicated for the palliative treatment of patients with ovarian carcinoma recurrent after prior chemotherapy, including patients who have been previously treated with cisplatin.
DB00995AuranofinUsed in the treatment of active, progressive or destructive forms of inflammatory arthritis, such as adult rheumatoid arthritis.
DB01169Arsenic trioxideFor induction of remission and consolidation in patients with acute promyelocytic leukemia (APL), and whose APL is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression
DB01592IronUsed in preventing and treating iron-deficiency anemia.
DB03006Arsanilic acidNot Available
DB04874PicoplatinFor the treatment of patients with solid tumors.
DB04992AP5346For the treatment of various forms of cancer.
DB04996SatraplatinInvestigated for use/treatment in lung cancer, prostate cancer, and solid tumors.
DB05112AP5280Investigated for use/treatment in solid tumors.
DB05488Technetium Tc-99m ciprofloxacinInvestigated for use/treatment in infectious and parasitic disease (unspecified).
DB05630Sodium stibogluconateFor the treatment of various types of a protozoal infection called leishmaniasis, which may result from sandfly bites in tropical and temperate parts of the world. Also investigated for use/treatment in cancer/tumors (unspecified) and solid tumors.
DB06179DarinaparsinInvestigated for use/treatment in blood (blood forming organ disorders, unspecified), cancer/tumors (unspecified), solid tumors, multiple myeloma, and liver cancer.
DB06215FerumoxytolThis drug is indicated for the treatment of iron deficiency anemia in adult patients who have experienced intolerance to oral iron or have experienced an unsatisfactory response to oral iron or who have chronic kidney disease (CKD) [FDA label].
DB06783Prussian blueIndicated for treatment of patients with known or suspected internal contamination with radioactive cesium and/or radioactive or non-radioactive thallium to increase their rates of elimination.
DB08857Bamet-UD2Not Available
DB08858cis-Diamminechlorocholylglycinateplatinum(II)Not Available
DB08884Gadoxetic acidGadoxetate is used as a contrast medium for magnetic resonance imaging (MRI) to detect and characterize lesions in the liver.
DB08917Ferric carboxymaltoseFerric carboxymaltose is a iron replacement product indicated for the treatment of iron deficiency anemia in adult patients who have intolerance to oral iron or have had unsatisfactory response to oral iron or those who have non-dialysis dependent chronic kidney disease.
DB08928ArsthinolAntiprotozoal agent effective against amoebiasis and yaws.
DB09121AurothioglucoseAurothioglucose is indicated for the adjunctive treatment of early active adult and juvenile type rheumatoid arthritis that is not adequately controlled by other anti-inflammatory agents and conservative measures like salicylate, glucocorticoids, etc. [L1925, L1937]. In chronic, advanced cases of rheumatoid arthritis, such gold therapy is not demonstrated to be as valuable [L1937]. Antirheumatic measures such as salicylate and other anti-inflammatory drugs (both steroidal and non steroidal) may be continued after initiation of gold therapy [L1937]. After improvement commences, these measures may be discontinued slowly as symptoms permit [L1937].
DB09137Technetium Tc-99m mebrofeninTechnetium Tc 99m Mebrofenin is indicated as a hepatobiliary imaging agent.
DB09138Technetium Tc-99m medronateTechnetium Tc 99m Medronate is indicated for use as a bone imaging agent to delineate areas of altered osteogenesis.
DB09146Iron saccharateIron sucrose is elemental iron as an injection. It replenishes body iron stores in patients with iron deficiency.
DB09161Technetium Tc-99m sestamibiTechnetium Tc 99m Sestamibi is indicated for: 1) detecting coronary artery disease by localizing myocardial ischemia (reversible defects) and infarction (non-reversible defects); and 2) evaluating myocardial function and developing information for use in patient management decisions.
DB09163Technetium Tc-99m exametazimeTechnetium Tc99m exametazime scintigraphy (with or without methylene blue stabilization) may be useful as an adjunct in the detection of altered regional cerebral perfusion in stroke. Tc99m exametazime without methylene blue stabilization is indicated for leukocyte labeled scintigraphy as an adjunct in the localization of intra-abdominal infection and inflammatory bowel disease.
DB09164Technetium Tc-99m disofeninTechnetium Tc99m Disofenin is indicated as a hepatobiliary imaging agent. Hepatolite is indicated in the diagnosis of acute cholecystitis as well as to rule out the occurrence of acute cholecystitis in suspected patients with right upper quadrant pain, fever, jaundice, right upper quadrant tenderness and mass or rebound tenderness, but not limited to these signs and symptoms.
DB09276Sodium aurothiomalateA disease-modifying antirheumatic drug (DMARD) indicated for the symptomatic treatment of arthritis.
DB09338MersalylElevated blood pressure, edema [L1577, L1585].
DB09501Ferric ammonium citrateNot Available
DB09507FerumoxsilNot Available
DB09508FerumoxidesNot Available
DB11171Ferric sulfateFerric sulfate was first used in dermatology as part of the Monsel's solution. This solution is an antihemorrhagic agent used in skin and mucosal biopsies. The use of ferric sulfate in dermatology is under review as ferric sulfate is corrosive and injurious and it can cause degenerative changes that are not observed with other alternatives like collagen.[A32357] Ferric sulfate is also used as a coagulative and hemostatic agent. It is a mechanic hemostatic agent used directly on the damaged tissue.[A32355] In dentistry, ferric sulfate is used as a pulpotomy medicament to control pulpal bleeding, as an antibacterial agent and as a hemostatic reagent for restorative dentistry, for postextraction hemorrhage and for periradicular and endodontic surgery.[A32356]
DB11210Ferrous bisglycinateNot Available
DB11417GleptoferronNot Available
DB11437NitarsoneNot Available
DB11458RoxarsoneNot Available
DB11576Ferric oxideNot Available
DB11590ThimerosalUsed as preservative in some cosmetics, topical pharmaceuticals, and biological drug products, which includes vaccines [L1671, L1672, L1673].
DB12208Iron isomaltoside 1000Not Available
DB12821PerflubutaneNot Available
DB12864MelarsoprolNot Available
DB13049LobaplatinNot Available
DB13145NedaplatinUsed in the treatment of non-small cell lung cancer, small cell lung cancer, oesophygeal cancer, and head and neck cancers [A20300].
DB13257Ferrous sulfate anhydrousFor the prevention and treatment of iron deficiency anemia [L2252].
DB13268AcetarsolAcetarsol has been used for the treatment of different diseases such as syphilis, amoebiasis, yaws, trypanosomiasis, and malaria.[L2624] Acetarsol was used commonly for the treatment of vaginitis due to _Trichomonas vaginalis_ and _Candida albicans_.[A32839, A32841] When orally administered, acetarsol can be used for the treatment of intestinal amoebiasis and in the form of suppositories it has been researched for the treatment of proctitis.[L2626] Protozoan infections are parasitic diseases characterized to be caused by organisms classified in the kingdom Protozoa which is formed by a great diversity of organisms.[L2627]
DB13381Sodium feredetateNot Available
DB13392MercurochromeNot Available
DB13423Ferric hydroxideNot Available
DB13569Ferrous chlorideNot Available
DB13763AurotioprolNot Available
DB13885Ferric subsulfateNot Available
DB13985Lutetium Lu 177 dotatateIndicated for the treatment of somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs), including foregut, midgut, and hindgut neuroendocrine tumors in adults [FDA Label].
DB14026Thiosalicylic acidNot Available
DB14488Ferrous gluconateUsed in preventing and treating iron-deficiency anemia.
DB14489Ferrous succinateUsed in preventing and treating iron-deficiency anemia.
DB14491Ferrous fumarateUsed in preventing and treating iron-deficiency anemia.
DB14520Tetraferric tricitrate decahydrateFor the control of serum phosphorus levels in patients with chronic kidney disease on dialysis, as ferric citrate.
DB14695Ferric oxyhydroxideNot Available
DB02994Cacodylic acidNot Available
DB04456Arsenous acidNot Available
DB00364SucralfateThe sucralfate suspension [FDA label] and tablet [F4534] are used for the treatment of active duodenal ulcer for up to 8 weeks. The tablet form may be used at a lower dose for healed duodenal ulcers, for the purpose of maintaining healing and preventing recurrence [F4519, F4534]. Sucralfate is also used in the prevention and/or treatment of gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia [A177655, F4519].
DB14807Demplatin pegraglumerNot Available
DrugDrug NameTargetType
DB00113Technetium Tc-99m arcitumomabCarcinoembryonic antigen-related cell adhesion molecule 1target
DB00325NitroprussideAtrial natriuretic peptide receptor 1target
DB00325NitroprussideCytochrome P450 1A1enzyme
DB00526OxaliplatinSolute carrier family 22 member 2transporter
DB00526OxaliplatinHigh affinity copper uptake protein 1transporter
DB00526OxaliplatinSolute carrier family 22 member 3transporter
DB00526OxaliplatinATP-binding cassette sub-family G member 2transporter
DB00526OxaliplatinCytochrome P450 1A1enzyme
DB00526OxaliplatinCytochrome P450 1B1enzyme
DB00526OxaliplatinCytochrome P450 2E1enzyme
DB00526OxaliplatinGlutathione S-transferase theta-1enzyme
DB00526OxaliplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00526OxaliplatinGlutathione S-transferase Penzyme
DB00526OxaliplatinGlutathione S-transferase Mu 1enzyme
DB00526OxaliplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00526OxaliplatinCanalicular multispecific organic anion transporter 1transporter
DB00526OxaliplatinCopper-transporting ATPase 2transporter
DB00526OxaliplatinCopper-transporting ATPase 1transporter
DB00534ChlormerodrinSuccinate-semialdehyde dehydrogenase, mitochondrialtarget
DB00534ChlormerodrinSolute carrier family 12 member 1target
DB00789Gadopentetic acid6-phosphogluconate dehydrogenase, decarboxylatingtarget
DB00893Iron DextranHemoglobin subunit betatarget
DB00893Iron DextranHemoglobin subunit alphatarget
DB00893Iron DextranFerritin heavy chaintarget
DB00893Iron DextranFerritin light chaintarget
DB00893Iron DextranSerotransferrincarrier
DB00958CarboplatinHigh affinity copper uptake protein 1transporter
DB00958CarboplatinProbable low affinity copper uptake protein 2transporter
DB00958CarboplatinXanthine dehydrogenase/oxidaseenzyme
DB00958CarboplatinGlutathione S-transferase theta-1enzyme
DB00958CarboplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00958CarboplatinGlutathione S-transferase Penzyme
DB00958CarboplatinGlutathione S-transferase Mu 1enzyme
DB00958CarboplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00958CarboplatinCopper-transporting ATPase 1transporter
DB00958CarboplatinCopper-transporting ATPase 2transporter
DB00958CarboplatinATP-binding cassette sub-family G member 2transporter
DB00958CarboplatinCanalicular multispecific organic anion transporter 1transporter
DB00995AuranofinInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00995AuranofinSerum albumincarrier
DB00995AuranofinPeroxiredoxin-5, mitochondrialtarget
DB01169Arsenic trioxideInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB01169Arsenic trioxideTranscription factor AP-1target
DB01169Arsenic trioxideG1/S-specific cyclin-D1target
DB01169Arsenic trioxideMitogen-activated protein kinase 3target
DB01169Arsenic trioxideMitogen-activated protein kinase 1target
DB01169Arsenic trioxideRAC-alpha serine/threonine-protein kinasetarget
DB01169Arsenic trioxideCytochrome P450 1A1enzyme
DB01169Arsenic trioxideCanalicular multispecific organic anion transporter 1transporter
DB01169Arsenic trioxideThioredoxin reductase 1, cytoplasmictarget
DB01169Arsenic trioxideMultidrug resistance protein 1transporter
DB01169Arsenic trioxideCytochrome P450 1B1enzyme
DB01169Arsenic trioxideCytochrome P450 3A4enzyme
DB01169Arsenic trioxideCyclin-dependent kinase inhibitor 1target
DB01169Arsenic trioxideHistone deacetylase 1target
DB01169Arsenic trioxideProtein PMLtarget
DB01169Arsenic trioxideSerum albumincarrier
DB01592IronTransferrin receptor protein 1target
DB01592IronEgl nine homolog 1target
DB01592IronHistone deacetylase 8target
DB01592IronAlpha-hemoglobin-stabilizing proteintarget
DB01592IronHemoglobin subunit alphatarget
DB01592IronFrataxin, mitochondrialtarget
DB01592IronFerritin heavy chaintarget
DB01592IronFlap endonuclease 1target
DB01592IronEndonuclease 8-like 1target
DB01592IronEndonuclease 8-like 2target
DB01592IronDNA polymerase betatarget
DB03006Arsanilic acidLysozyme Ctarget
DB05488Technetium Tc-99m ciprofloxacinDNA gyrase subunit Btarget
DB05488Technetium Tc-99m ciprofloxacinDNA topoisomerase 2-betatarget
DB05488Technetium Tc-99m ciprofloxacinCytochrome P450 1A2enzyme
DB05630Sodium stibogluconateDNA topoisomerase 1target
DB06215FerumoxytolFerritin light chaintransporter
DB06215FerumoxytolFerritin heavy chaintransporter
DB08857Bamet-UD2Solute carrier organic anion transporter family member 1B1transporter
DB08858cis-Diamminechlorocholylglycinateplatinum(II)Solute carrier organic anion transporter family member 1B1transporter
DB08884Gadoxetic acidSolute carrier organic anion transporter family member 1B1transporter
DB08884Gadoxetic acidSolute carrier organic anion transporter family member 1B3transporter
DB08884Gadoxetic acidCanalicular multispecific organic anion transporter 2transporter
DB08884Gadoxetic acidCanalicular multispecific organic anion transporter 1transporter
DB08884Gadoxetic acidMultidrug resistance-associated protein 4transporter
DB09121AurothioglucoseAdenylate cyclase type 1target
DB09121AurothioglucoseAdenylate cyclase type 2target
DB09121AurothioglucoseAdenylate cyclase type 5target
DB09137Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B1transporter
DB09137Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B3transporter
DB09146Iron saccharateHemoglobin subunit alphatarget
DB09146Iron saccharateSerotransferrincarrier
DB09161Technetium Tc-99m sestamibiMultidrug resistance protein 1transporter
DB09161Technetium Tc-99m sestamibiMultidrug resistance-associated protein 1transporter
DB09276Sodium aurothiomalateUDP-glucuronosyltransferase 1-1enzyme
DB09338MersalylAlkaline phosphatase, tissue-nonspecific isozymetarget
DB09338MersalylMonocarboxylate transporter 1target
DB09338MersalylInter-alpha-trypsin inhibitor heavy chain H1enzyme
DB09338MersalylPhosphoenolpyruvate carboxykinase, cytosolic [GTP]enzyme
DB11590ThimerosalSerum albumincarrier
DB11590ThimerosalInositol 1,4,5-trisphosphate receptor type 1transporter
DB11590ThimerosalMethionine synthasetarget
DB11590ThimerosalCystine/glutamate transportertarget
DB11590ThimerosalSodium/potassium-transporting ATPase subunit gammatarget
DB11590ThimerosalGlutathione reductase, mitochondrialenzyme
DB11590ThimerosalGlutathione peroxidase 1enzyme
DB11590ThimerosalSuperoxide dismutase [Mn], mitochondrialenzyme
DB13257Ferrous sulfate anhydrousSerotransferrintransporter
DB13257Ferrous sulfate anhydrousFerritin light chaintransporter
DB13257Ferrous sulfate anhydrousFerritin heavy chaintransporter
DB13257Ferrous sulfate anhydrousDivalent metal ion transporter 1transporter
DB13257Ferrous sulfate anhydrousIron binding protein FbpAtransporter
DB13257Ferrous sulfate anhydrousNADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialenzyme
DB13257Ferrous sulfate anhydrousSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialenzyme
DB13257Ferrous sulfate anhydrousXanthine dehydrogenase/oxidaseenzyme
DB13257Ferrous sulfate anhydrousAconitate hydratase, mitochondrialenzyme
DB13257Ferrous sulfate anhydrousCytochrome P450 4A11enzyme
DB13257Ferrous sulfate anhydrousSulfite oxidase, mitochondrialenzyme
DB13257Ferrous sulfate anhydrousMyeloperoxidaseenzyme
DB13257Ferrous sulfate anhydrousCatalaseenzyme
DB13257Ferrous sulfate anhydrousNitric oxide synthase, inducibleenzyme
DB13257Ferrous sulfate anhydrousProstaglandin G/H synthase 1enzyme
DB13257Ferrous sulfate anhydrousProstaglandin G/H synthase 2enzyme
DB13257Ferrous sulfate anhydrousTryptophan 5-hydroxylase 1enzyme
DB13257Ferrous sulfate anhydrousProlyl 4-hydroxylase subunit alpha-1enzyme
DB13257Ferrous sulfate anhydrousRibonucleoside-diphosphate reductase large subunitenzyme
DB13257Ferrous sulfate anhydrousPterin-4-alpha-carbinolamine dehydrataseenzyme
DB13257Ferrous sulfate anhydrousTrimethyllysine dioxygenase, mitochondrialenzyme
DB13257Ferrous sulfate anhydrousCeruloplasminenzyme
DB13257Ferrous sulfate anhydrousFree radicalstarget
DB13985Lutetium Lu 177 dotatateSomatostatin receptor type 2target
DB13985Lutetium Lu 177 dotatateSomatostatin receptor type 1target
DB13985Lutetium Lu 177 dotatateSomatostatin receptor type 3target
DB13985Lutetium Lu 177 dotatateSomatostatin receptor type 4target
DB13985Lutetium Lu 177 dotatateSomatostatin receptor type 5target
DB14488Ferrous gluconateTransferrin receptor protein 1target
DB14488Ferrous gluconateEgl nine homolog 1target
DB14488Ferrous gluconateHistone deacetylase 8target
DB14488Ferrous gluconateAlpha-hemoglobin-stabilizing proteintarget
DB14488Ferrous gluconateHemoglobin subunit alphatarget
DB14488Ferrous gluconateFrataxin, mitochondrialtarget
DB14488Ferrous gluconateFerritin heavy chaintarget
DB14488Ferrous gluconateFlap endonuclease 1target
DB14488Ferrous gluconateEndonuclease 8-like 1target
DB14488Ferrous gluconateEndonuclease 8-like 2target
DB14488Ferrous gluconateDNA polymerase betatarget
DB14488Ferrous gluconateCeruloplasmintarget
DB14488Ferrous gluconateSerotransferrintarget
DB14489Ferrous succinateTransferrin receptor protein 1target
DB14489Ferrous succinateEgl nine homolog 1target
DB14489Ferrous succinateHistone deacetylase 8target
DB14489Ferrous succinateAlpha-hemoglobin-stabilizing proteintarget
DB14489Ferrous succinateHemoglobin subunit alphatarget
DB14489Ferrous succinateFrataxin, mitochondrialtarget
DB14489Ferrous succinateFerritin heavy chaintarget
DB14489Ferrous succinateFlap endonuclease 1target
DB14489Ferrous succinateEndonuclease 8-like 1target
DB14489Ferrous succinateEndonuclease 8-like 2target
DB14489Ferrous succinateDNA polymerase betatarget
DB14489Ferrous succinateCeruloplasmintarget
DB14489Ferrous succinateSerotransferrintarget
DB14491Ferrous fumarateTransferrin receptor protein 1target
DB14491Ferrous fumarateEgl nine homolog 1target
DB14491Ferrous fumarateHistone deacetylase 8target
DB14491Ferrous fumarateAlpha-hemoglobin-stabilizing proteintarget
DB14491Ferrous fumarateHemoglobin subunit alphatarget
DB14491Ferrous fumarateFrataxin, mitochondrialtarget
DB14491Ferrous fumarateFerritin heavy chaintarget
DB14491Ferrous fumarateFlap endonuclease 1target
DB14491Ferrous fumarateEndonuclease 8-like 1target
DB14491Ferrous fumarateEndonuclease 8-like 2target
DB14491Ferrous fumarateDNA polymerase betatarget
DB14491Ferrous fumarateCeruloplasmintarget
DB14491Ferrous fumarateSerotransferrintarget
DB14520Tetraferric tricitrate decahydrateSerotransferrincarrier
DB14520Tetraferric tricitrate decahydrateIron(3+)-hydroxamate-binding protein FhuDtarget
DB14520Tetraferric tricitrate decahydrateIntegrin beta-3carrier
DB14520Tetraferric tricitrate decahydrateCalreticulincarrier
DB14520Tetraferric tricitrate decahydrateTransferrin receptor protein 1target
DB02994Cacodylic acidGag-Pol polyproteintarget
DB02994Cacodylic acidNitric oxide synthase, endothelialtarget
DB02994Cacodylic acidAldose reductasetarget
DB02994Cacodylic acidGuanine nucleotide-binding protein G(t) subunit alpha-1target
DB04456Arsenous acidArsenate reductasetarget
DB04456Arsenous acidArsenical pump-driving ATPasetarget
DB00364SucralfatePro-epidermal growth factortarget
DB00364SucralfateFibroblast growth factor 2target