Identification
NameTechnetium Tc-99m sestamibi
Accession NumberDB09161
TypeSmall Molecule
GroupsApproved
Description

Technetium Tc-99m sestamibi (commonly sestamibi) is a pharmaceutical agent used in nuclear medicine imaging. The drug is a coordination complex consisting of the radioisotope technetium-99m bound to six (sesta=6) methoxyisobutylisonitrile (MIBI) ligands. Following intravenous injection of the drug, Technetium Tc-99m sestamibi is taken up by the myocardium, parathyroid, and/or breast tissue. The mechanism by which sestamibi localizes to these tissues has not been established. Single photon emission computed tomography (SPECT) is then performed to detect the gamma ray emmitted by the decay of Technetium-99m to Technetium-99.

Currently available within a preparation kit for injection, Technetium Tc 99m Sestamibi is indicated for: 1) detecting coronary artery disease by localizing myocardial ischemia (reversible defects) and infarction (non-reversible defects); and 2) evaluating myocardial function and developing information for use in patient management decisions.

Structure
Thumb
Synonyms
99m Tc-sestamibi
99m-Tc sestamibi
99mTc sestamibi
99mTc-sestamibi
Sestamibi
Technetium (99m Tc) sestamibi
Technetium (99mTc) sestamibi
Technetium Tc 99m sestamibi
External IDs Not Available
Product Ingredients Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Kit for The Preparation Of Technetium Tc 99m SestamibiInjection1 mg/10mLIntravenousDraximage Llc2009-07-01Not applicableUs
Kit for the Preparation of Technetium Tc99m SestamibiInjection1 mg/10mLIntravenousPharmalucence, Inc.2009-07-10Not applicableUs
Kit for the Preparation of Technetium Tc99m SestamibiInjection, powder, lyophilized, for solution1 mg/5mLParenteralCardinal Health 414, Llc2010-06-01Not applicableUs
Technetium Tc 99m SestamibiInjection1 mg/mLIntravenousMallinckrodt2011-10-312017-07-01Us
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Categories
UNII971Z4W1S09
CAS number109581-73-9
WeightAverage: 775.96
Monoisotopic: 775.5
Chemical FormulaC36H66N6O6Tc
InChI KeyZBTQTVSNLRPJHI-UHFFFAOYSA-N
InChI
InChI=1S/6C6H11NO.Tc/c6*1-6(2,8-4)5-7-3;/h6*5H2,1-2,4H3;/q;;;;;;+1
IUPAC Name
technetium(1+) ion hexakis(1-isocyano-2-methoxy-2-methylpropane)
SMILES
[Tc+].COC(C)(C)C[N+]#[C-].COC(C)(C)C[N+]#[C-].COC(C)(C)C[N+]#[C-].COC(C)(C)C[N+]#[C-].COC(C)(C)C[N+]#[C-].COC(C)(C)C[N+]#[C-]
Pharmacology
Indication

Technetium Tc 99m Sestamibi is indicated for: 1) detecting coronary artery disease by localizing myocardial ischemia (reversible defects) and infarction (non-reversible defects); and 2) evaluating myocardial function and developing information for use in patient management decisions.

Structured Indications
PharmacodynamicsNot Available
Mechanism of actionNot Available
Related Articles
Absorption

At five minutes post injection about 8% of the injected dose remains in circulation. Myocardial uptake which is coronary flow dependent is 1.2% of the injected dose at rest and 1.5% of the injected dose at exercise.

Volume of distributionNot Available
Protein binding

There is less than 1% protein binding of Technetium Tc 99m Sestamibi in plasma.

Metabolism

The agent is excreted without any evidence of metabolism.

Route of elimination

The major pathway for clearance of Tc 99m Sestamibi is the hepatobiliary system. Activity from the gall bladder appears in the intestines within one hour of injection. Twenty-seven percent of the injected dose is excreted in the urine, and approximately thirty-three percent of the injected dose is cleared through the feces in 48 hours.

Half life

Technetium Tc 99m decays by isomeric transition with a physical half-life of 6.02 hours. Blood clearance studies indicate that the fast clearing component clears with a t½ of 4.3 minutes at rest, and clears with a t½ of 1.6 minutes under exercise conditions. The myocardial biological half-life is approximately six hours after a rest or exercise injection. The biological half-life for the liver is approximately 30 minutes after a rest or exercise injection.

Clearance

The effective half-life of clearance (which includes both the biological half-life and radionuclide decay) for the heart is approximately 3 hours, and for the liver is approximately 30 minutes, after a rest or exercise injection.

Toxicity

The following adverse reactions have been reported in > 0.5% of patients: signs and symptoms consistent with seizure occurring shortly after administration of the agent; transient arthritis; angioedema, arrhythmia, dizziness, syncope, abdominal pain, vomiting, and severe hypersensitivity characterized by dyspnea, hypotension, bradycardia, asthenia, and vomiting within two hours after a second injection of Technetium Tc 99m Sestamibi. A few cases of flushing, edema, injection site inflammation, dry mouth, fever, pruritis, rash, urticaria and fatigue have also been attributed to administration of the agent.

Affected organismsNot Available
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
AcetaminophenThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Acetaminophen.Approved
AfatinibThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Afatinib.Approved
AlbendazoleThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Albendazole.Approved, Vet Approved
AldosteroneThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Aldosterone.Experimental
AlectinibThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Alectinib.Approved
AlfentanilThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Alfentanil.Approved, Illicit
AmantadineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Amantadine.Approved
Aminohippuric acidThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Aminohippuric acid.Approved
AmiodaroneThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Amiodarone.Approved, Investigational
AmitriptylineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Amitriptyline.Approved
AmlodipineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Amlodipine.Approved
AmprenavirThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Amprenavir.Approved
AmsacrineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Amsacrine.Approved
AstemizoleThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Astemizole.Approved, Withdrawn
AtazanavirThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Atenolol.Approved
AtorvastatinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Atorvastatin.Approved
AzelastineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Azelastine.Approved
AzithromycinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Azithromycin.Approved
BenzocaineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Benzocaine.Approved
BepridilThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Bepridil.Approved, Withdrawn
BiperidenThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Biperiden.Approved
BosutinibThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Bosutinib.Approved
BromocriptineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Bromocriptine.Approved, Investigational
BuprenorphineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Buspirone.Approved, Investigational
CabazitaxelThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Cabazitaxel.Approved
CaffeineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Caffeine.Approved
CanagliflozinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Canagliflozin.Approved
CandesartanThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Candesartan.Approved
CaptoprilThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Captopril.Approved
CarbamazepineThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarvedilolThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Carvedilol.Approved, Investigational
CaspofunginThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Caspofungin.Approved
ChloroquineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Chloroquine.Approved, Vet Approved
ChlorpromazineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Chlorpromazine.Approved, Vet Approved
ChlorpropamideThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
CholesterolThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Cholesterol.Experimental
Cholic AcidThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Cholic Acid.Approved
CilazaprilThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Cilazapril.Approved
CimetidineThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Cimetidine.Approved
CiprofloxacinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ciprofloxacin.Approved, Investigational
CitalopramThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Citalopram.Approved
ClarithromycinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Clarithromycin.Approved
ClofazimineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Clofazimine.Approved, Investigational
ClomipramineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Clomipramine.Approved, Vet Approved
ClotrimazoleThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Clotrimazole.Approved, Vet Approved
CobicistatThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Cobicistat.Approved
ColchicineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Colchicine.Approved
ColforsinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Colforsin.Experimental
CrizotinibThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Crizotinib.Approved
CyclophosphamideThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Cyclophosphamide.Approved, Investigational
CyclosporineThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Cyclosporine.Approved, Investigational, Vet Approved
DaclatasvirThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Daclatasvir.Approved
DactinomycinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Dactinomycin.Approved
DasatinibThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Daunorubicin.Approved
DesipramineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Desipramine.Approved
DesloratadineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Desloratadine.Approved, Investigational
DexamethasoneThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DextromethorphanThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Dextromethorphan.Approved
DiclofenacThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Diclofenac.Approved, Vet Approved
DigoxinThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Digoxin.Approved
DihydroergotamineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Dihydroergotamine.Approved
DiltiazemThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Diltiazem.Approved
DipyridamoleThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Dipyridamole.Approved
DoxazosinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Doxazosin.Approved
DoxepinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Doxorubicin.Approved, Investigational
DronabinolThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Dronabinol.Approved, Illicit
DronedaroneThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Dronedarone.Approved
ElbasvirThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Elbasvir.Approved
EnalaprilThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Enalapril.Approved, Vet Approved
EnzalutamideThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Enzalutamide.Approved
ErgonovineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ergonovine.Approved
ErgotamineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ergotamine.Approved
ErythromycinThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Erythromycin.Approved, Vet Approved
EstramustineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Estramustine.Approved
EstriolThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Estriol.Approved, Vet Approved
EstroneThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Estrone.Approved
EtoposideThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Etoposide.Approved
EtravirineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Etravirine.Approved
FelodipineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Felodipine.Approved, Investigational
FentanylThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Fexofenadine.Approved
FidaxomicinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Fidaxomicin.Approved
FluconazoleThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Fluconazole.Approved
FluoxetineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Fluphenazine.Approved
FlurazepamThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Flurazepam.Approved, Illicit
FluvoxamineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Fluvoxamine.Approved, Investigational
GefitinibThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Gefitinib.Approved, Investigational
GenisteinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Genistein.Investigational
GlyburideThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Glyburide.Approved
Gramicidin DThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Gramicidin D.Approved
GrepafloxacinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Grepafloxacin.Withdrawn
HaloperidolThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Haloperidol.Approved
HydrocortisoneThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Hydrocortisone.Approved, Vet Approved
IdelalisibThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Idelalisib.Approved
ImatinibThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Imatinib.Approved
ImipramineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Imipramine.Approved
IndinavirThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Indinavir.Approved
IndomethacinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Indomethacin.Approved, Investigational
IsavuconazoniumThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Isavuconazonium.Approved, Investigational
ItraconazoleThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ivermectin.Approved, Vet Approved
KetamineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ketamine.Approved, Vet Approved
KetoconazoleThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ketoconazole.Approved, Investigational
LansoprazoleThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Lansoprazole.Approved, Investigational
LapatinibThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Lapatinib.Approved, Investigational
LevofloxacinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Levofloxacin.Approved, Investigational
LevothyroxineThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Levothyroxine.Approved
LidocaineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Lidocaine.Approved, Vet Approved
LiothyronineThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Liotrix.Approved
LisinoprilThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Lisinopril.Approved, Investigational
LomitapideThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Lomitapide.Approved
LoperamideThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Loperamide.Approved
LopinavirThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Lopinavir.Approved
LoratadineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Loratadine.Approved
LosartanThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Losartan.Approved
LovastatinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Lovastatin.Approved, Investigational
LumacaftorThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Lumacaftor.Approved
MaprotilineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Maprotiline.Approved
MebendazoleThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Mebendazole.Approved, Vet Approved
MefloquineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Mefloquine.Approved
Megestrol acetateThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MeprobamateThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Meprobamate.Approved, Illicit
MethadoneThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Methadone.Approved
MetoprololThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Metoprolol.Approved, Investigational
MibefradilThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Mibefradil.Withdrawn
MiconazoleThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Midazolam.Approved, Illicit
MifepristoneThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Mifepristone.Approved, Investigational
MitomycinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Mitomycin.Approved
MitoxantroneThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Mitoxantrone.Approved, Investigational
MorphineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Morphine.Approved, Investigational
NaltrexoneThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaringeninThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Naringenin.Experimental
NefazodoneThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Nelfinavir.Approved
NeostigmineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Neostigmine.Approved, Vet Approved
NicardipineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Nicardipine.Approved
NifedipineThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Nifedipine.Approved
NilotinibThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Nilotinib.Approved, Investigational
NisoldipineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Nisoldipine.Approved
NitrazepamThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Nitrazepam.Approved
NitrendipineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Nitrendipine.Approved
NorethisteroneThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Norethisterone.Approved
OmeprazoleThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
P-NitrophenolThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Paclitaxel.Approved, Vet Approved
Palmitic AcidThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Palmitic Acid.Experimental
PantoprazoleThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Pantoprazole.Approved
ParoxetineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Paroxetine.Approved, Investigational
PerindoprilThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Perindopril.Approved
PhenobarbitalThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Phenobarbital.Approved
PimozideThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Pimozide.Approved
Platelet Activating FactorThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Platelet Activating Factor.Experimental
PonatinibThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ponatinib.Approved
PosaconazoleThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PravastatinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Pravastatin.Approved
PrazosinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Prazosin.Approved
PrednisoneThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Prednisone.Approved, Vet Approved
ProbenecidThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Probenecid.Approved
ProgesteroneThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Progesterone.Approved, Vet Approved
PromethazineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Promethazine.Approved
PropafenoneThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Propafenone.Approved
PropranololThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Propranolol.Approved, Investigational
ProtriptylineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Protriptyline.Approved
QuercetinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Quercetin.Experimental
QuinacrineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Quinacrine.Approved
QuinidineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Quinidine.Approved
QuinineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Quinine.Approved
RanitidineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ranolazine.Approved, Investigational
ReboxetineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Reboxetine.Approved, Investigational
RegorafenibThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Regorafenib.Approved
ReserpineThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Reserpine.Approved
RifampicinThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Rifampicin.Approved
RilpivirineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Rilpivirine.Approved
RitonavirThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Ritonavir.Approved, Investigational
RolapitantThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Rolapitant.Approved
SaquinavirThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Saquinavir.Approved, Investigational
ScopolamineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Scopolamine.Approved
SelegilineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Selegiline.Approved, Investigational, Vet Approved
SertralineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Sertraline.Approved
SimeprevirThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Simeprevir.Approved
SimvastatinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Simvastatin.Approved
SirolimusThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Sirolimus.Approved, Investigational
SorafenibThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Sorafenib.Approved, Investigational
SpironolactoneThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Spironolactone.Approved
St. John's WortThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with St. John's Wort.Nutraceutical
StaurosporineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Staurosporine.Experimental
StreptozocinThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Streptozocin.Approved
SulfinpyrazoneThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Sulfinpyrazone.Approved
SumatriptanThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Sunitinib.Approved, Investigational
TacrineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Tacrine.Withdrawn
TacrolimusThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Tacrolimus.Approved, Investigational
TamoxifenThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Tamoxifen.Approved
Taurocholic AcidThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Taurocholic Acid.Experimental
TelmisartanThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Telmisartan.Approved, Investigational
TemsirolimusThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Temsirolimus.Approved
TerazosinThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Terazosin.Approved
TerfenadineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Terfenadine.Withdrawn
TesmilifeneThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Tesmilifene.Investigational
TestosteroneThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Testosterone.Approved, Investigational
TicagrelorThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Ticagrelor.Approved
TolvaptanThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Tolvaptan.Approved
TrazodoneThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Trazodone.Approved, Investigational
TrifluoperazineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethoprimThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Trimethoprim.Approved, Vet Approved
TrimipramineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Trimipramine.Approved
VenlafaxineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Venlafaxine.Approved
VerapamilThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Verapamil.Approved
VinblastineThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Vinblastine.Approved
VincristineThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Vincristine.Approved, Investigational
VinorelbineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Vinorelbine.Approved, Investigational
ZimelidineThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Zimelidine.Withdrawn
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General References
  1. Hendrikse NH, Franssen EJ, van der Graaf WT, Meijer C, Piers DA, Vaalburg W, de Vries EG: 99mTc-sestamibi is a substrate for P-glycoprotein and the multidrug resistance-associated protein. Br J Cancer. 1998;77(3):353-8. [PubMed:9472628 ]
  2. Ma Q, Chen B, Gao S, Ji T, Wen Q, Song Y, Zhu L, Xu Z, Liu L: 99mTc-3P4-RGD2 scintimammography in the assessment of breast lesions: comparative study with 99mTc-MIBI. PLoS One. 2014 Sep 24;9(9):e108349. doi: 10.1371/journal.pone.0108349. eCollection 2014. [PubMed:25250628 ]
  3. Tiling R, Tatsch K, Sommer H, Meyer G, Pechmann M, Gebauer K, Munzing W, Linke R, Khalkhali I, Hahn K: Technetium-99m-sestamibi scintimammography for the detection of breast carcinoma: comparison between planar and SPECT imaging. J Nucl Med. 1998 May;39(5):849-56. [PubMed:9591588 ]
External Links
ATC CodesV09GA01 — Technetium (99mtc) sestamibi
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelDownload (4.09 MB)
MSDSNot Available
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
0RecruitingDiagnosticCancer, Breast / Malignant Neoplasm of Breast1
3CompletedDiagnosticMucocutaneous Lymph Node Syndrome1
4CompletedDiagnosticCoronary Artery Disease / Diabetes, Diabetes Mellitus Type 11
Not AvailableCompletedDiagnosticCancer, Breast2
Not AvailableCompletedDiagnosticMyocardial Perfusion1
Not AvailableTerminatedDiagnosticIschaemic Heart Diseases / Myocardial Infarction (MI)1
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
InjectionIntravenous1 mg/10mL
Injection, powder, lyophilized, for solutionParenteral1 mg/5mL
InjectionIntravenous1 mg/mL
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.00465 mg/mLALOGPS
logP5.44ALOGPS
logP-1.3ChemAxon
logS-5.2ALOGPS
pKa (Strongest Acidic)16.14ChemAxon
pKa (Strongest Basic)-4.2ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area13.59 Å2ChemAxon
Rotatable Bond Count12ChemAxon
Refractivity41.61 m3·mol-1ChemAxon
Polarizability12.7 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET featuresNot Available
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
ClassificationNot classified

Transporters

Kind
Protein
Organism
Human
Pharmacological action
no
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Uniprot Name:
Multidrug resistance protein 1
Molecular Weight:
141477.255 Da
References
  1. Hendrikse NH, Franssen EJ, van der Graaf WT, Meijer C, Piers DA, Vaalburg W, de Vries EG: 99mTc-sestamibi is a substrate for P-glycoprotein and the multidrug resistance-associated protein. Br J Cancer. 1998;77(3):353-8. [PubMed:9472628 ]
Kind
Protein
Organism
Human
Pharmacological action
no
Actions
substrate
General Function:
Transporter activity
Specific Function:
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
Gene Name:
ABCC1
Uniprot ID:
P33527
Uniprot Name:
Multidrug resistance-associated protein 1
Molecular Weight:
171589.5 Da
References
  1. Hendrikse NH, Franssen EJ, van der Graaf WT, Meijer C, Piers DA, Vaalburg W, de Vries EG: 99mTc-sestamibi is a substrate for P-glycoprotein and the multidrug resistance-associated protein. Br J Cancer. 1998;77(3):353-8. [PubMed:9472628 ]
Drug created on October 02, 2015 14:20 / Updated on September 01, 2017 12:03