Nitro Compounds

Name
Nitro Compounds
Accession Number
DBCAT000765
Description

Compounds having the nitro group, -NO2, attached to carbon. When attached to nitrogen they are nitramines and attached to oxygen they are NITRATES.

Drugs
DrugDrug Description
TolcaponeA catechol-O-methyltransferase (COMT) inhibitor used as adjunct therapy in the symptomatic management of idiopathic Parkinson's disease.
NitrofuralFor the treatment of bacterial skin infections including pyodermas, infected dermatoses and infections of cuts, wounds, burns and ulcers due to susceptible organisms.
ChloramphenicolA broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity.
FurazolidoneFor the specific and symptomatic treatment of bacterial or protozoal diarrhea and enteritis caused by susceptible organisms.
NitrofurantoinAn antibiotic used to treat urinary tract infections.
NitroglycerinA nitrate vasodilator used to treat or prevent angina, treat hypertension, control heart failure in myocardial infarction, and to induce hypotension intraoperatively.
TinidazoleA nitroimidazole used to treat trichomoniasis, giardiasis, amebiasis, and bacterial vaginosis.
MetronidazoleA nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections.
OxamniquineFor treatment of Schistosomiasis caused by Schistosoma mansoni
NitroxolineNitroxoline is an antibiotic agent.
Picric acidUsed as antiseptic, astringent, and stimulant for epitheliazation.
4-Nitrophenyl PhosphateNot Available
P-NitrophenolNot Available
2,4-DinitrophenolA toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman,...
PretomanidPart of a three-drug regimen used for the treatment of extensively drug-resistant and multidrug-resistant pulmonary tuberculosis.
EvofosfamideInvestigated for use/treatment in solid tumors.
BromamphenicolNot Available
Chloramphenicol succinateA broad-spectrum antibiotic agent used for the treatment of acute and severe infections caused by susceptible bacterial strains.
ThiamphenicolNot Available
EfonidipineFor the treatment of hypertension.
FlorfenicolFlorfenicol is a fluorinated synthetic analog of thiamphenicol.
NifurpirinolNot Annotated
DelamanidAn antibiotic used to treat multidrug resistant tuberculosis.
MisonidazoleMisonidazole is under investigation in clinical trial NCT00038038 (Assessment of Head and Neck Tumor Hypoxia Using 18F-Fluoromisonidazole).
NifurtimoxNifurtimox has been investigated for the treatment of Sleeping Sickness and Human African Trypanosomiasis.
DinitrochlorobenzeneDinitrochlorobenzene has been used in trials studying the treatment of HIV Infections.
BenznidazoleA trypanocidal agent used to treat Chagas disease.
NimorazoleNimorazole has been used in trials studying the treatment of Hypoxia, Radiotherapy, Hypoxic Modification, Gene Profile, Gene Signature, and Head and Neck Squamous Cell Carcinoma, among others.
FexinidazoleFexinidazole has been investigated for the treatment of Disease, Chagas and South American Trypanosomiasis.
PimonidazolePimonidazole is under investigation for the diagnostic of Prostate Cancer and Head and Neck Cancer.
EtanidazoleEtanidazole has been used in trials studying the diagnostic of Adult Ependymoma, Malignant Ascites, Adult Gliosarcoma, Adult Mixed Glioma, and Adult Glioblastoma, among others.
SecnidazoleA nitroimidazole antibiotic used to treat bacterial vaginosis.
OrnidazoleOrnidazole has been used in trials studying the prevention of Elective Colorectal Surgery.
NifurzideNot Annotated
AzanidazoleNot Annotated
FurazidinNot Annotated
ClefamideNot Annotated
NifuratelNot Annotated
NifurtoinolNot Annotated
NifuroxazideNot Annotated
NS-398NS-398 is a COX-2 inhibitor. It was developed as part of the mechanistic study of the cyclooxygenases.
Chloramphenicol palmitateNot Annotated
MorinidazoleMorinidazole is under investigation in clinical trial NCT03380793 (A Trial to Assess the Efficacy and Safety of Morinidazole in Patients With Appendicitis).
Fluoroazomycin arabinoside F-18Fluoroazomycin arabinoside F-18 is under investigation in clinical trial NCT03257150 (A Study of the Use of Irreversible Electroporation in Pancreatic Ductal Cancer).
AzidamfenicolNot Annotated
1,3-DinitrobenzeneNot Available
Drugs & Drug Targets
DrugTargetType
TolcaponeCatechol O-methyltransferasetarget
TolcaponeCytochrome P450 2C9enzyme
NitrofuralPyruvate dehydrogenase [ubiquinone]target
NitrofuralGlutathione reductasetarget
NitrofuralMalate dehydrogenasetarget
Nitrofural[Citrate [pro-3S]-lyase] ligasetarget
NitrofuralXanthine dehydrogenase/oxidaseenzyme
ChloramphenicolComplement decay-accelerating factortarget
ChloramphenicolDr hemagglutinin structural subunittarget
ChloramphenicolCytochrome P450 2C19enzyme
ChloramphenicolCytochrome P450 3A4enzyme
ChloramphenicolCytochrome P450 3A5enzyme
ChloramphenicolCytochrome P450 3A7enzyme
ChloramphenicolSolute carrier family 22 member 6transporter
Chloramphenicol50S ribosomal protein L16target
ChloramphenicolChloramphenicol acetyltransferase 3enzyme
ChloramphenicolChloramphenicol acetyltransferaseenzyme
ChloramphenicolChloramphenicol 3-O phosphotransferaseenzyme
FurazolidoneDNAtarget
FurazolidoneAmine oxidase [flavin-containing] Benzyme
FurazolidoneAmine oxidase [flavin-containing] Aenzyme
Nitrofurantoin30S ribosomal protein S10target
NitrofurantoinOxygen-insensitive NADPH nitroreductasetarget
NitrofurantoinProbable pyruvate-flavodoxin oxidoreductasetarget
NitrofurantoinATP-binding cassette sub-family G member 2transporter
NitrofurantoinNADPH--cytochrome P450 reductaseenzyme
NitrofurantoinBile salt export pumptransporter
NitrofurantoinP-glycoprotein 1transporter
NitrofurantoinCanalicular multispecific organic anion transporter 1transporter
NitroglycerinAtrial natriuretic peptide receptor 1target
NitroglycerinAldehyde dehydrogenase, mitochondrialenzyme
TinidazoleCytochrome P450 3A4enzyme
TinidazoleDNAtarget
TinidazoleBile salt export pumptransporter
MetronidazoleOxygen-insensitive NADPH nitroreductasetarget
MetronidazoleCytochrome P450 2C9enzyme
MetronidazoleCytochrome P450 3A4enzyme
MetronidazoleCytochrome P450 2C8enzyme
MetronidazoleUDP-glucuronosyltransferase 1-1enzyme
MetronidazoleAnaerobic bacterial DNAtarget
MetronidazoleProtozoal DNAtarget
MetronidazoleP-glycoprotein 1transporter
MetronidazoleCytochrome P450 2A6enzyme
MetronidazoleCytochrome P450 3A5enzyme
MetronidazoleCytochrome P450 3A7enzyme
OxamniquineDNAtarget
OxamniquineCytochrome P450 2D6enzyme
NitroxolineMethionine aminopeptidase 2target
NitroxolineMagnesium cationtarget
NitroxolineManganese cationtarget
Picric acidPentaerythritol tetranitrate reductasetarget
4-Nitrophenyl PhosphateLow molecular weight phosphotyrosine protein phosphatasetarget
4-Nitrophenyl PhosphateDual specificity protein phosphatase 23target
P-NitrophenolSulfotransferase 1A1target
P-NitrophenolAlpha-amylase 2Btarget
2,4-DinitrophenolPentaerythritol tetranitrate reductasetarget
PretomanidDeazaflavin-dependent nitroreductaseenzyme
PretomanidSolute carrier family 22 member 8transporter
PretomanidCytochrome P450 3A4enzyme
PretomanidFatty acid synthetasetarget
PretomanidUncharacterized MFS-type transporter EfpAtarget
PretomanidNucleoid-associated protein Lsr2target
PretomanidCyd operon, Mycobacterium tuberculosistarget
PretomanidEnoyl-[acyl-carrier-protein] reductase [NADH]target
BromamphenicolDr hemagglutinin structural subunittarget
Chloramphenicol succinateDr hemagglutinin structural subunittarget
ThiamphenicolDr hemagglutinin structural subunittarget
EfonidipineVoltage-dependent T-type calcium channel subunit alpha-1Itarget
EfonidipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
EfonidipineCytochrome P450 3A4enzyme
DelamanidDeazaflavin-dependent nitroreductaseenzyme
DelamanidCytochrome P450 3A4enzyme
DelamanidSerum albumincarrier
DelamanidAlpha-1-acid glycoprotein 1carrier
DinitrochlorobenzeneMethylated-DNA--protein-cysteine methyltransferasetarget
DinitrochlorobenzeneGlutathione S-transferase Ptarget
NS-398Cyclooxygenase 2target
1,3-DinitrobenzeneMannan endo-1,4-beta-mannosidasetarget