Six-membered heterocycles containing an oxygen and a nitrogen.
DrugDrug NameDrug Indication
DB00234ReboxetineFor the treatment of clinical depression.
DB00373TimololThe oral form is used to treat high blood pressure and prevent heart attacks, and occasionally to prevent migraine headaches. Ophthalmic timolol is indicated for the treamtnet of open-angle and occasionally secondary glaucoma.
DB00625EfavirenzFor use in combination treatment of HIV infection (AIDS)
DB00673AprepitantFor the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy, including high-dose cisplatin (in combination with other antiemetic agents).
DB00680MoricizineUsed to treat irregular heartbeats (arrhythmias) and maintain a normal heart rate.
DB00830PhenmetrazineUsed as an anorectic in the treatment of obesity.
DB01181IfosfamideUsed as a component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer. Also used as a component of various chemotherapeutic regimens for the treatment of cervical cancer, as well as in conjunction with surgery and/or radiation therapy in the treatment of various soft tissue sarcomas. Other indications include treatment of osteosarcoma, bladder cancer, ovarian cancer. small cell lung cancer, and non-Hodgkin's lymphoma.
DB01529DextromoramideNot Available
DB01579PhendimetrazineUsed in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction.
DB02341Mdl 101,146Not Available
DB02656LY-294002Not Available
DB04787TanaprogetNot Available
DB05227APD791For the treatment and prophylaxis of arterial thrombosis.
DB05424CanertinibInvestigated for use/treatment in breast cancer and lung cancer.
DB05611ApilimodInvestigated for use/treatment in crohn's disease and psoriasis and psoriatic disorders.
DB05668PalifosfamideInvestigated for use/treatment in cancer/tumors (unspecified), lymphoma (unspecified), and sarcoma.
DB06177GlufosfamideInvestigated for use/treatment in pancreatic cancer, solid tumors, breast cancer, colorectal cancer, brain cancer, lung cancer, ovarian cancer, and sarcoma.
DB06228RivaroxabanRivaroxaban is indicated for the prevention of venous thromboembolic events (VTE) in patients who have undergone total hips replacements and total knee replacement surgery; prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation; treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE); to reduce risk of recurrent DVT and/or PE. Rivaroxaban is also indicated, in combination with aspirin, for reducing the risk of major cardiovascular events in patients with chronic coronary artery disease or peripheral artery disease. Due to a lack of safety studies, it is not recommended for use in those under 18 years old. Its use is also not recommended in those with severe renal impairment (<30mL/min).
DB06586CetilistatInvestigated for use/treatment in obesity.
DB06638QuarfloxinInvestigated for use/treatment in leukemia (lymphoid).
DB06717FosaprepitantFor the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy.
DB08968FominobenNot Available
DB09056AmorolfineNot Available
DB09080OlodaterolOlodaterol is indicated for use in chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema. It is not indicated for the treatment of acute exacerbations of COPD or for the treatment of asthma.
DB09090PinaveriumPinaverium is indicated for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract.
DB09184EdivoxetineNot Available
DB09185ViloxazineIndicated for the treatment of clinical depression.
DB09196LubazodoneNot Available
DB09209PholcodinePholcodine is indicated as a cough suppressant for the temporary relief of non-productive dry cough. It is stated to present a required label indication of "temporary relief of dry cough."[L1200] Cough is the respiratory movement that occurs after an irritation signal is transmitted to the central nervous system and further stimulates the medulla oblongata. This stimulation causes a motor output that is sent through motoneurons to the respiratory muscles. A non-productive cough is a type of cough characterized by the absence of sputum, and it has a large inspiration that will cause continuous coughing.
DB09282MolsidomineThe indications for use of molsidomine include ischemic heart disease, angina, chronic heart failure, and pulmonary hypertension [L1370, L1371].
DB09345PramocaineIt is indicated for temporary relief of pain and pruritus from minor lip and skin irritations as well as for temporary relief from pain, burning, itching and discomfort associated with hemorrhoids and other anorectal/anogenital disorders.
DB11666BuparlisibNot Available
DB11675MosaprideNot Available
DB11891CUDC-907Not Available
DB11896GedatolisibNot Available
DB11925VistusertibNot Available
DB11934EpelsibanNot Available
DB12212LandiololNot Available
DB12395EsreboxetineNot Available
DB12774AZD-8055Not Available
DB12986VS-5584Not Available
DB13020ApratastatNot Available
DB13109PKI-179Not Available
DB13400LinsidomineNot Available
DB13457OxaflozaneNot Available
DB13597MoroxydineNot Available
DB13666Tiemonium iodideNot Available
DB13669MorpholineNot Available
DB13781XamoterolNot Available
DB13950WIN 55212-2Not Available
DB14202MorpholinylmercaptobenzothiazoleNot Available
DB14923SatavaptanNot Available
DrugDrug NameTargetType
DB00234ReboxetineSodium-dependent noradrenaline transportertarget
DB00234ReboxetineCytochrome P450 3A4enzyme
DB00234ReboxetineCytochrome P450 2D6enzyme
DB00234ReboxetineMultidrug resistance protein 1transporter
DB00373TimololBeta-1 adrenergic receptortarget
DB00373TimololBeta-2 adrenergic receptortarget
DB00373TimololCytochrome P450 2D6enzyme
DB00373TimololMultidrug resistance protein 1transporter
DB00373TimololCytochrome P450 2C19enzyme
DB00373TimololLysozymetarget
DB00625EfavirenzCytochrome P450 2B6enzyme
DB00625EfavirenzCytochrome P450 3A4enzyme
DB00625EfavirenzCytochrome P450 2C19enzyme
DB00625EfavirenzCytochrome P450 2C9enzyme
DB00625EfavirenzCytochrome P450 1A2enzyme
DB00625EfavirenzCytochrome P450 2D6enzyme
DB00625EfavirenzReverse transcriptase/RNaseHtarget
DB00625EfavirenzCytochrome P450 2C8enzyme
DB00625EfavirenzSerum albumincarrier
DB00625EfavirenzCytochrome P450 3A5enzyme
DB00625EfavirenzCytochrome P450 3A7enzyme
DB00625EfavirenzUDP-glucuronosyltransferase 1-1enzyme
DB00625EfavirenzBile salt export pumptransporter
DB00625EfavirenzSolute carrier family 22 member 1transporter
DB00673AprepitantSubstance-P receptortarget
DB00673AprepitantCytochrome P450 3A4enzyme
DB00673AprepitantCytochrome P450 2C9enzyme
DB00673AprepitantCytochrome P450 3A5enzyme
DB00673AprepitantCytochrome P450 3A7enzyme
DB00673AprepitantCytochrome P450 2C19enzyme
DB00680MoricizineSodium channel protein type 5 subunit alphatarget
DB00830PhenmetrazineSodium-dependent noradrenaline transportertarget
DB00830PhenmetrazineSodium-dependent dopamine transportertarget
DB01181IfosfamideCytochrome P450 2B6enzyme
DB01181IfosfamideDNAtarget
DB01181IfosfamideCytochrome P450 3A4enzyme
DB01181IfosfamideCytochrome P450 3A5enzyme
DB01181IfosfamideCytochrome P450 2C9enzyme
DB01181IfosfamideCytochrome P450 2C8enzyme
DB01181IfosfamideCytochrome P450 2A6enzyme
DB01181IfosfamideCytochrome P450 2C19enzyme
DB01181IfosfamideCytochrome P450 2C18enzyme
DB01181IfosfamideProstaglandin G/H synthase 1enzyme
DB01181IfosfamideNuclear receptor subfamily 1 group I member 2target
DB01579PhendimetrazineAlpha-1A adrenergic receptortarget
DB01579PhendimetrazineAlpha-1B adrenergic receptortarget
DB01579PhendimetrazineSodium-dependent noradrenaline transportertarget
DB02341Mdl 101,146Chymotrypsin-like elastase family member 1target
DB02341Mdl 101,146Neutrophil elastasetarget
DB02656LY-294002Serine/threonine-protein kinase pim-1target
DB02656LY-294002Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformtarget
DB04787TanaprogetProgesterone receptortarget
DB05227APD7915-hydroxytryptamine receptor 2Atarget
DB05424CanertinibEpidermal growth factor receptortarget
DB05668PalifosfamideDNA (cytosine-5)-methyltransferase 1target
DB06228RivaroxabanCoagulation factor Xtarget
DB06228RivaroxabanCytochrome P450 3A4enzyme
DB06228RivaroxabanCytochrome P450 2J2enzyme
DB06228RivaroxabanMultidrug resistance protein 1transporter
DB06228RivaroxabanCytochrome P450 3A5enzyme
DB06228RivaroxabanATP-binding cassette sub-family G member 2transporter
DB06586CetilistatPancreatic triacylglycerol lipasetarget
DB06717FosaprepitantCytochrome P450 3A4enzyme
DB06717FosaprepitantCytochrome P450 2C9enzyme
DB09080OlodaterolBeta-2 adrenergic receptortarget
DB09080OlodaterolCytochrome P450 2C9enzyme
DB09080OlodaterolCytochrome P450 2C8enzyme
DB09090PinaveriumVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB09090PinaveriumCytochrome P450 3A4enzyme
DB09185ViloxazineSodium-dependent noradrenaline transportertarget
DB09185ViloxazineCytochrome P450 1A2enzyme
DB09209PholcodineMu-type opioid receptortarget
DB09209PholcodineKappa-type opioid receptortarget
DB09209PholcodineDelta-type opioid receptortarget
DB09282MolsidomineGuanylate cyclase soluble subunit alpha-2target
DB09282MolsidomineGuanylate cyclase soluble subunit alpha-2enzyme
DB09282MolsidominecGMP-specific 3',5'-cyclic phosphodiesteraseenzyme
DB09345PramocaineVoltage gated sodium channeltarget
DB12212LandiololCytochrome P450 2D6enzyme
DB13781XamoterolBeta-1 adrenergic receptortarget
DB13950WIN 55212-2Cytochrome P450 3A4enzyme