Six-membered heterocycles containing an oxygen and a nitrogen.
DrugDrug NameDrug Description
DB00234ReboxetineFor the treatment of clinical depression.
DB00373TimololA non-selective beta adrenergic blocker used in the treatment of elevated intraocular pressure in ocular hypertension or open angle glaucoma.
DB00625EfavirenzA non-nucleoside reverse transcriptase inhibitor used to treat HIV infection or prevent the spread of HIV.
DB00673AprepitantA substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery.
DB00680MoricizineAn antiarrhythmic used to treat arrhythmias.
DB00830PhenmetrazineUsed as an anorectic in the treatment of obesity.
DB01181IfosfamideAn alkylating and immunosuppressive agent used in chemotherapy for the treatment of cancers, including testicular cancer, ovarian cancer, cervical cancer, osteocarcinoma, bladder cancer, small cell lung cancer, and non-Hodgkin's lymphoma.
DB01529DextromoramideAn opioid analgesic structurally related to methadone and used in the treatment of severe pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1070)
DB01579PhendimetrazineA sympathomimetic amine used as adjunct therapy for the short term management of exogenous obesity.
DB02341Mdl 101,146Not Available
DB02656LY-294002Specific inhibitor of phosphatidylinositol 3-kinase.
DB04787TanaprogetTanaproget (NSP-989) is an investigational non-steroidal progestin. It is a high affinity, high efficacy agonist of the progesterone receptor (PR) with a much more selective binding profile relative to most...
DB05227APD791For the treatment and prophylaxis of arterial thrombosis.
DB05424CanertinibInvestigated for use/treatment in breast cancer and lung cancer.
DB05611ApilimodInvestigated for use/treatment in crohn's disease and psoriasis and psoriatic disorders.
DB05668PalifosfamideInvestigated for use/treatment in cancer/tumors (unspecified), lymphoma (unspecified), and sarcoma.
DB06177GlufosfamideInvestigated for use/treatment in pancreatic cancer, solid tumors, breast cancer, colorectal cancer, brain cancer, lung cancer, ovarian cancer, and sarcoma.
DB06228RivaroxabanA factor Xa inhibitor used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). May also be used as thrombosis prophylaxis in specific situations.
DB06586CetilistatInvestigated for use/treatment in obesity.
DB06638QuarfloxinInvestigated for use/treatment in leukemia (lymphoid).
DB06717FosaprepitantAn antiemetic drug used in combination with other antiemetic agents for the prevention of acute and delayed nausea and vomiting caused by chemotherapy.
DB08968FominobenFominoben is an antitussive agent.
DB09056AmorolfineAmorolfine or amorolfin, is a morpholine antifungal drug that inhibits the fungal enzymes D14 reductase and D7-D8 isomerase. This inhibition affects fungal sterol synthesis pathways, depleting ergosterol and causing ignosterol...
DB09080OlodaterolA long-acting beta2-adrenergic agonist used in the management of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema.
DB09090PinaveriumA spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract.
DB09184EdivoxetineEdivoxetine is a drug which acts as a selective norepinephrine reuptake inhibitor and is currently under development by Eli Lilly for attention-deficit hyperactivity disorder (ADHD) and as an antidepressant treatment....
DB09185ViloxazineIndicated for the treatment of clinical depression.
DB09196LubazodoneLubazodone (YM-992, YM-35,995) is an arylpiperazine antidepressant which was being developed as a treatment for depression and obsessive compulsive disorder, and reached phase II clinical trials, but was discontinued. It...
DB09209PholcodinePholcodine is indicated as a cough suppressant for the temporary relief of non-productive dry cough. It is stated to present a required label indication of "temporary relief of dry cough."...
DB09282MolsidomineThe indications for use of molsidomine include ischemic heart disease, angina, chronic heart failure, and pulmonary hypertension [L1370, L1371].
DB09345PramocaineA local anesthetic and antipruritic agent found in various topical preparations.
DB11666BuparlisibBuparlisib has been used in trials studying the treatment and basic science of Lymphoma, Metastases, Lung Cancer, Solid Tumors, and Breast Cancer, among others.
DB11675MosaprideMosapride is under investigation for the treatment and prevention of Postoperative Ileus and Gastric Peroral Endoscopic Pyloromyotomy (G-POEM). Mosapride has been investigated for the treatment and diagnostic of Constipation, Type...
DB11891CUDC-907CUDC-907 has been used in trials studying the treatment of Lymphoma, Solid Tumors, BREAST CANCER, Multiple Myeloma, and NUT Midline Carcinoma, among others.
DB11896GedatolisibGedatolisib has been used in trials studying the basic science and treatment of Neoplasm, Ovary Cancer, Breast Cancer, Advanced Cancer, and Endometrial Cancer, among others.
DB11925VistusertibVistusertib is under investigation for the treatment of Advanced Gastric Adenocarcinoma.
DB11934EpelsibanEpelsiban has been investigated for the treatment of Premature Ejaculation.
DB12212LandiololLandiolol has been used in trials studying the treatment of Pharmacokinetics/Dynamics Study.
DB12395EsreboxetineEsreboxetine has been used in trials studying the treatment and basic science of Fibromyalgia.
DB12774AZD-8055AZD8055 has been used in trials studying the treatment of Cancer, Lymphomas, Solid Tumors, MALIGNANT GLIOMA, and brainstem glioma, among others.
DB12986VS-5584VS-5584 has been used in trials studying the treatment of Lymphoma, Metastatic Cancer, and Non Hematologic Cancers.
DB13020ApratastatTmi 005 is under investigation in clinical trial NCT00095342 (Study Evaluating TMI-005 in Active Rheumatoid Arthritis).
DB13109PKI-179PKI-179 has been used in trials studying the treatment of Advanced Malignant Solid Tumors.
DB13400LinsidomineNot Annotated
DB13457OxaflozaneNot Annotated
DB13597MoroxydineNot Annotated
DB13666Tiemonium iodideNot Annotated
DB13669MorpholineNot Annotated
DB13781XamoterolXamoterol is a β1-adrenoceptor partial agonist that has shown to improve systolic and diastolic function in studies with heart failure patients. It modulates the sympathetic control of the heart but...
DB13950WIN 55212-2WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure. It...
DB14202MorpholinylmercaptobenzothiazoleNot Annotated
DB14923SatavaptanSatavaptan is under investigation in clinical trial NCT00359437 (Satavaptan in the Prevention of Ascites Recurrence in Patients With Ascites Due to Cirrhosis of the Liver).
DB06014EteplirsenAn antisense oligonucleotide used to treat Duchenne muscular dystrophy (DMD) only in patients who are confirmed to have a specific type of mutation.
DB11795GSK-2636771GSK2636771 has been used in trials studying the treatment of CANCER, LYMPHOMA, Solid Neoplasm, Recurrent Solid Neoplasm, and Advanced Malignant Neoplasm, among others.
DB12571RimacalibRimacalib has been used in trials studying the treatment of Rheumatoid Arthritis (RA).
DB14935SerabelisibSerabelisib is under investigation in clinical trial NCT02625259 (A Study to Evaluate the Relative Bioavailability, Effect of Food, and Gastric Potential Hydrogen (pH) Modification on the Pharmacokinetics of TAK-117 (MLN1117)...
DB15332RadavirsenRadavirsen is under investigation in clinical trial NCT01375985 (Safety Study of Single Administration Intravenous Treatment for Influenza).
DrugDrug NameTargetType
DB00234ReboxetineSodium-dependent noradrenaline transportertarget
DB00234ReboxetineCytochrome P450 3A4enzyme
DB00234ReboxetineCytochrome P450 2D6enzyme
DB00234ReboxetineP-glycoprotein 1transporter
DB00373TimololBeta-1 adrenergic receptortarget
DB00373TimololBeta-2 adrenergic receptortarget
DB00373TimololCytochrome P450 2D6enzyme
DB00373TimololP-glycoprotein 1transporter
DB00373TimololCytochrome P450 2C19enzyme
DB00625EfavirenzCytochrome P450 2B6enzyme
DB00625EfavirenzCytochrome P450 3A4enzyme
DB00625EfavirenzCytochrome P450 2C19enzyme
DB00625EfavirenzCytochrome P450 2C9enzyme
DB00625EfavirenzCytochrome P450 1A2enzyme
DB00625EfavirenzCytochrome P450 2D6enzyme
DB00625EfavirenzReverse transcriptase/RNaseHtarget
DB00625EfavirenzCytochrome P450 2C8enzyme
DB00625EfavirenzSerum albumincarrier
DB00625EfavirenzCytochrome P450 3A5enzyme
DB00625EfavirenzCytochrome P450 3A7enzyme
DB00625EfavirenzUDP-glucuronosyltransferase 1-1enzyme
DB00625EfavirenzBile salt export pumptransporter
DB00625EfavirenzSolute carrier family 22 member 1transporter
DB00673AprepitantNeurokinin 1 receptortarget
DB00673AprepitantCytochrome P450 3A4enzyme
DB00673AprepitantCytochrome P450 2C9enzyme
DB00673AprepitantCytochrome P450 2C19enzyme
DB00680MoricizineSodium channel protein type 5 subunit alphatarget
DB00830PhenmetrazineSodium-dependent noradrenaline transportertarget
DB00830PhenmetrazineSodium-dependent dopamine transportertarget
DB01181IfosfamideCytochrome P450 2B6enzyme
DB01181IfosfamideCytochrome P450 3A4enzyme
DB01181IfosfamideCytochrome P450 3A5enzyme
DB01181IfosfamideCytochrome P450 2C9enzyme
DB01181IfosfamideCytochrome P450 2C8enzyme
DB01181IfosfamideCytochrome P450 2A6enzyme
DB01181IfosfamideCytochrome P450 2C19enzyme
DB01181IfosfamideCytochrome P450 2C18enzyme
DB01181IfosfamideProstaglandin G/H synthase 1enzyme
DB01181IfosfamideNuclear receptor subfamily 1 group I member 2target
DB01579PhendimetrazineAlpha-1A adrenergic receptortarget
DB01579PhendimetrazineAlpha-1B adrenergic receptortarget
DB01579PhendimetrazineSodium-dependent noradrenaline transportertarget
DB02341Mdl 101,146Chymotrypsin-like elastase family member 1target
DB02341Mdl 101,146Neutrophil elastasetarget
DB02656LY-294002Serine/threonine-protein kinase pim-1target
DB02656LY-294002Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformtarget
DB04787TanaprogetProgesterone receptortarget
DB05227APD7915-hydroxytryptamine receptor 2Atarget
DB05424CanertinibEpidermal growth factor receptortarget
DB05668PalifosfamideDNA (cytosine-5)-methyltransferase 1target
DB06228RivaroxabanCoagulation factor Xtarget
DB06228RivaroxabanCytochrome P450 3A4enzyme
DB06228RivaroxabanCytochrome P450 2J2enzyme
DB06228RivaroxabanP-glycoprotein 1transporter
DB06228RivaroxabanCytochrome P450 3A5enzyme
DB06228RivaroxabanATP-binding cassette sub-family G member 2transporter
DB06586CetilistatPancreatic triacylglycerol lipasetarget
DB06717FosaprepitantCytochrome P450 3A4enzyme
DB06717FosaprepitantCytochrome P450 2C9enzyme
DB09080OlodaterolBeta-2 adrenergic receptortarget
DB09080OlodaterolCytochrome P450 2C9enzyme
DB09080OlodaterolCytochrome P450 2C8enzyme
DB09090PinaveriumVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB09090PinaveriumCytochrome P450 3A4enzyme
DB09185ViloxazineSodium-dependent noradrenaline transportertarget
DB09185ViloxazineCytochrome P450 1A2enzyme
DB09209PholcodineMu-type opioid receptortarget
DB09209PholcodineKappa-type opioid receptortarget
DB09209PholcodineDelta-type opioid receptortarget
DB09282MolsidomineGuanylate cyclase soluble subunit alpha-2target
DB09282MolsidomineGuanylate cyclase soluble subunit alpha-2enzyme
DB09282MolsidominecGMP-specific 3',5'-cyclic phosphodiesteraseenzyme
DB09345PramocaineVoltage-gated sodium channel alpha subunittarget
DB12212LandiololCytochrome P450 2D6enzyme
DB13781XamoterolBeta-1 adrenergic receptortarget
DB13950WIN 55212-2Cytochrome P450 3A4enzyme
DB06014EteplirsenDMD-001 gene (exon 51 target site)target