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Identification
NameFosaprepitant
Accession NumberDB06717
TypeSmall Molecule
GroupsApproved
DescriptionFosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment.
Structure
Thumb
Synonyms
Fosaprepitantum
L-758,298
L-758298
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
EmendInjection, powder, lyophilized, for solution115 mg/5mLIntravenousMerck Sharp & Dohme Corp.2008-01-252016-02-18Us
EmendInjection, powder, lyophilized, for solution150 mg/5mLIntravenousMerck Sharp & Dohme Corp.2008-01-25Not applicableUs
Emend IVPowder, for solution115 mgIntravenousMerck Canada Inc2009-04-302010-10-28Canada
Emend IVPowder, for solution150 mgIntravenousMerck Canada Inc2011-04-04Not applicableCanada
FosaprepitantPowder, for solution150 mgIntravenousApotex IncNot applicableNot applicableCanada
IvemendInjection, powder, for solution150 mgIntravenousMerck Sharp & Dohme Ltd2008-01-11Not applicableEu
IvemendInjection, powder, for solution150 mgIntravenousMerck Sharp & Dohme Ltd2008-01-11Not applicableEu
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Fosaprepitant dimeglumine
265121-04-8
Thumb
  • InChI Key: VRQHBYGYXDWZDL-OOZCZQCLSA-N
  • Monoisotopic Mass: 1004.337863721
  • Average Mass: 1004.8337
DBSALT000089
Categories
UNII6L8OF9XRDC
CAS number172673-20-0
WeightAverage: 614.4066
Monoisotopic: 614.116518403
Chemical FormulaC23H22F7N4O6P
InChI KeyBARDROPHSZEBKC-OITMNORJSA-N
InChI
InChI=1S/C23H22F7N4O6P/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)40-20-19(13-2-4-17(24)5-3-13)33(6-7-39-20)11-18-31-21(35)34(32-18)41(36,37)38/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H,31,32,35)(H2,36,37,38)/t12-,19+,20-/m1/s1
IUPAC Name
(3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo-2,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonic acid
SMILES
C[C@@H](O[[email protected]]1OCCN(CC2=NC(=O)N(N2)P(O)(O)=O)[[email protected]]1C1=CC=C(F)C=C1)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F
Pharmacology
IndicationFor the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy.
Structured Indications
PharmacodynamicsFosaprepitant is a prodrug of Aprepitant. Once biologically activated, the drug acts as a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting (CI NV).
Mechanism of actionAprepitant has been shown in animal models to inhibit emesis induced by cytotoxic chemotherapeutic agents, such as cisplatin, via central actions. Animal and human Positron Emission Tomography (PET) studies with Aprepitant have shown that it crosses the blood brain barrier and occupies brain NK1 receptors. Animal and human studies show that Aprepitant augments the antiemetic activity of the 5-HT3-receptor antagonist ondansetron and the corticosteroid ethasone and inhibits both the acute and delayed phases of cisplatin induced emesis. In summary, the active form of fosaprepitant is as an NK1 antagonist which is because it blocks signals given off by NK1 receptors. This therefore decreases the likelihood of vomiting in patients experiencing.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein binding95% +
Metabolism

Aprepitant is metabolized primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19. Seven metabolites of aprepitant, which are only weakly active, have been identified in human plasma.

Route of eliminationAprepitant is eliminated primarily by metabolism; aprepitant is not renally excreted. Aprepitant is excreted in the milk of rats. It is not known whether this drug is excreted in human milk.
Half life9-13 hours
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be increased when it is combined with Fosaprepitant.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be increased when it is combined with Fosaprepitant.Experimental, Illicit
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Fosaprepitant.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be increased when it is combined with Fosaprepitant.Experimental, Illicit
AbirateroneThe serum concentration of Abiraterone can be increased when it is combined with Fosaprepitant.Approved
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Fosaprepitant.Approved
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Fosaprepitant.Approved
AdinazolamThe serum concentration of Adinazolam can be increased when it is combined with Fosaprepitant.Approved
AlbendazoleThe serum concentration of Albendazole can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Fosaprepitant.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Fosaprepitant.Experimental
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Fosaprepitant.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Fosaprepitant.Approved, Investigational
AliskirenThe serum concentration of Aliskiren can be increased when it is combined with Fosaprepitant.Approved, Investigational
AllylestrenolThe serum concentration of Allylestrenol can be increased when it is combined with Fosaprepitant.Approved
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Fosaprepitant.Approved, Investigational
AlogliptinThe serum concentration of Alogliptin can be increased when it is combined with Fosaprepitant.Approved
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Fosaprepitant.Approved, Withdrawn
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Fosaprepitant.Approved, Illicit, Investigational
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Fosaprepitant.Approved, Investigational
AmbroxolThe serum concentration of Ambroxol can be increased when it is combined with Fosaprepitant.Approved
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Fosaprepitant.Approved
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Fosaprepitant.Approved, Withdrawn
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Fosaprepitant.Approved
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Fosaprepitant.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Fosaprepitant.Approved
AmlodipineThe serum concentration of Amlodipine can be increased when it is combined with Fosaprepitant.Approved
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Fosaprepitant.Approved
AnecortaveThe serum concentration of Anecortave can be increased when it is combined with Fosaprepitant.Investigational
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Fosaprepitant.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Fosaprepitant.Approved
ApremilastThe serum concentration of Apremilast can be increased when it is combined with Fosaprepitant.Approved, Investigational
AprepitantThe serum concentration of Aprepitant can be increased when it is combined with Fosaprepitant.Approved, Investigational
ArgatrobanThe serum concentration of Argatroban can be increased when it is combined with Fosaprepitant.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Fosaprepitant.Approved, Investigational
ArtemetherThe serum concentration of Artemether can be increased when it is combined with Fosaprepitant.Approved
AsenapineThe serum concentration of Asenapine can be increased when it is combined with Fosaprepitant.Approved
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Fosaprepitant.Approved, Withdrawn
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Fosaprepitant.Approved, Investigational
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Fosaprepitant.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Fosaprepitant.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Fosaprepitant.Approved, Investigational
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Fosaprepitant.Approved
AzithromycinThe serum concentration of Azithromycin can be increased when it is combined with Fosaprepitant.Approved
BanoxantroneThe serum concentration of Banoxantrone can be increased when it is combined with Fosaprepitant.Investigational
BeclomethasoneThe serum concentration of Beclomethasone can be increased when it is combined with Fosaprepitant.Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Fosaprepitant.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Fosaprepitant.Approved
BenzphetamineThe serum concentration of Benzphetamine can be increased when it is combined with Fosaprepitant.Approved, Illicit
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Fosaprepitant.Approved
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
BexaroteneThe serum concentration of Bexarotene can be increased when it is combined with Fosaprepitant.Approved, Investigational
BezafibrateThe serum concentration of Bezafibrate can be increased when it is combined with Fosaprepitant.Approved
BicalutamideThe serum concentration of Bicalutamide can be increased when it is combined with Fosaprepitant.Approved
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Fosaprepitant.Approved
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Fosaprepitant.Approved
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Fosaprepitant.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Fosaprepitant.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Fosaprepitant.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Fosaprepitant.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Fosaprepitant.Approved
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Fosaprepitant.Approved
BromazepamThe serum concentration of Bromazepam can be increased when it is combined with Fosaprepitant.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Fosaprepitant.Approved, Investigational
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Fosaprepitant.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Fosaprepitant.Approved
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Fosaprepitant.Approved, Investigational
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Fosaprepitant.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be increased when it is combined with Fosaprepitant.Approved
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Fosaprepitant.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Fosaprepitant.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Fosaprepitant.Approved
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Fosaprepitant.Approved
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Fosaprepitant.Approved
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Fosaprepitant.Approved
CalcitriolThe serum concentration of Calcitriol can be increased when it is combined with Fosaprepitant.Approved, Nutraceutical
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Fosaprepitant.Approved
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Fosaprepitant.Approved, Investigational
CarbinoxamineThe serum concentration of Carbinoxamine can be increased when it is combined with Fosaprepitant.Approved
CariprazineThe serum concentration of Cariprazine can be increased when it is combined with Fosaprepitant.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Fosaprepitant.Approved, Investigational
CelecoxibThe serum concentration of Celecoxib can be increased when it is combined with Fosaprepitant.Approved, Investigational
CeliprololThe serum concentration of Celiprolol can be increased when it is combined with Fosaprepitant.Approved, Investigational
CephalexinThe serum concentration of Cephalexin can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Fosaprepitant.Withdrawn
CevimelineThe serum concentration of Cevimeline can be increased when it is combined with Fosaprepitant.Approved
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be increased when it is combined with Fosaprepitant.Approved
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Fosaprepitant.Approved, Illicit
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Fosaprepitant.Withdrawn
ChlorphenamineThe serum concentration of Chlorphenamine can be increased when it is combined with Fosaprepitant.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Fosaprepitant.Approved
CholecalciferolThe serum concentration of Cholecalciferol can be increased when it is combined with Fosaprepitant.Approved, Nutraceutical
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Fosaprepitant.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Fosaprepitant.Approved
CinacalcetThe serum concentration of Cinacalcet can be increased when it is combined with Fosaprepitant.Approved
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Fosaprepitant.Approved, Investigational, Withdrawn
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Fosaprepitant.Approved
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Fosaprepitant.Approved
ClindamycinThe serum concentration of Clindamycin can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Fosaprepitant.Approved, Illicit
ClobetasolThe serum concentration of Clobetasol can be increased when it is combined with Fosaprepitant.Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Fosaprepitant.Approved
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Fosaprepitant.Approved
ClofazimineThe serum concentration of Clofazimine can be increased when it is combined with Fosaprepitant.Approved, Investigational
ClofibrateThe serum concentration of Clofibrate can be increased when it is combined with Fosaprepitant.Approved
clomethiazoleThe serum concentration of clomethiazole can be increased when it is combined with Fosaprepitant.Investigational
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
ClonazepamThe serum concentration of Clonazepam can be increased when it is combined with Fosaprepitant.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Fosaprepitant.Approved
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Fosaprepitant.Approved, Nutraceutical
ClorazepateThe serum concentration of Clorazepate can be increased when it is combined with Fosaprepitant.Approved, Illicit
ClotiazepamThe serum concentration of Clotiazepam can be increased when it is combined with Fosaprepitant.Approved, Illicit
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Fosaprepitant.Approved
CocaineThe serum concentration of Cocaine can be increased when it is combined with Fosaprepitant.Approved, Illicit
CodeineThe serum concentration of Codeine can be increased when it is combined with Fosaprepitant.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Fosaprepitant.Approved
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Fosaprepitant.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Fosaprepitant.Approved
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Fosaprepitant.Approved
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Fosaprepitant.Approved
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Fosaprepitant.Approved
CyclophosphamideThe serum concentration of Cyclophosphamide can be increased when it is combined with Fosaprepitant.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Fosaprepitant.Approved, Investigational, Vet Approved
CytarabineThe serum concentration of Cytarabine can be increased when it is combined with Fosaprepitant.Approved, Investigational
DabrafenibThe serum concentration of Dabrafenib can be increased when it is combined with Fosaprepitant.Approved
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Fosaprepitant.Approved
DantroleneThe serum concentration of Dantrolene can be increased when it is combined with Fosaprepitant.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Fosaprepitant.Approved
DapsoneThe serum concentration of Dapsone can be increased when it is combined with Fosaprepitant.Approved, Investigational
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Fosaprepitant.Approved, Investigational
DarunavirThe serum concentration of Darunavir can be increased when it is combined with Fosaprepitant.Approved
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Fosaprepitant.Approved
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Fosaprepitant.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Fosaprepitant.Approved
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Fosaprepitant.Investigational
DelavirdineThe serum concentration of Delavirdine can be increased when it is combined with Fosaprepitant.Approved
DesogestrelThe serum concentration of Desogestrel can be decreased when it is combined with Fosaprepitant.Approved
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Fosaprepitant.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Fosaprepitant.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be increased when it is combined with Fosaprepitant.Experimental, Vet Approved
DesvenlafaxineThe serum concentration of Desvenlafaxine can be increased when it is combined with Fosaprepitant.Approved
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Fosaprepitant.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Fosaprepitant.Vet Approved
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Fosaprepitant.Approved
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be increased when it is combined with Fosaprepitant.Approved, Illicit, Withdrawn
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Fosaprepitant.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Fosaprepitant.Approved
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Fosaprepitant.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Fosaprepitant.Approved
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Fosaprepitant.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Fosaprepitant.Approved
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Fosaprepitant.Approved
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Fosaprepitant.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Fosaprepitant.Approved
DihydrocodeineThe serum concentration of Dihydrocodeine can be increased when it is combined with Fosaprepitant.Approved, Illicit
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Fosaprepitant.Approved
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Fosaprepitant.Approved
DisopyramideThe serum concentration of Disopyramide can be increased when it is combined with Fosaprepitant.Approved
DisulfiramThe serum concentration of Disulfiram can be increased when it is combined with Fosaprepitant.Approved
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Fosaprepitant.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Fosaprepitant.Approved
DolasetronThe serum concentration of Dolasetron can be increased when it is combined with Fosaprepitant.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Fosaprepitant.Approved, Investigational, Vet Approved
DonepezilThe serum concentration of Donepezil can be increased when it is combined with Fosaprepitant.Approved
DorzolamideThe serum concentration of Dorzolamide can be increased when it is combined with Fosaprepitant.Approved
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Fosaprepitant.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Fosaprepitant.Approved, Investigational
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Fosaprepitant.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Fosaprepitant.Approved
DrospirenoneThe serum concentration of Drospirenone can be decreased when it is combined with Fosaprepitant.Approved
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Fosaprepitant.Approved, Investigational
EfavirenzThe serum concentration of Efavirenz can be increased when it is combined with Fosaprepitant.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Fosaprepitant.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Fosaprepitant.Approved
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Fosaprepitant.Approved
EnalaprilThe serum concentration of Enalapril can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Fosaprepitant.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Fosaprepitant.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Fosaprepitant.Approved
EquileninThe serum concentration of Equilenin can be increased when it is combined with Fosaprepitant.Experimental
EquilinThe serum concentration of Equilin can be increased when it is combined with Fosaprepitant.Approved
ErgocalciferolThe serum concentration of Ergocalciferol can be increased when it is combined with Fosaprepitant.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Fosaprepitant.Approved
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Fosaprepitant.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Fosaprepitant.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Fosaprepitant.Approved, Investigational
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
EscitalopramThe serum concentration of Escitalopram can be increased when it is combined with Fosaprepitant.Approved, Investigational
EsomeprazoleThe serum concentration of Esomeprazole can be increased when it is combined with Fosaprepitant.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Fosaprepitant.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Fosaprepitant.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be increased when it is combined with Fosaprepitant.Approved
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Fosaprepitant.Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Fosaprepitant.Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Fosaprepitant.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Fosaprepitant.Approved
EszopicloneThe serum concentration of Eszopiclone can be increased when it is combined with Fosaprepitant.Approved
EthanolThe serum concentration of Ethanol can be increased when it is combined with Fosaprepitant.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Fosaprepitant.Approved
EthosuximideThe serum concentration of Ethosuximide can be increased when it is combined with Fosaprepitant.Approved
EthylmorphineThe serum concentration of Ethylmorphine can be increased when it is combined with Fosaprepitant.Approved, Illicit
Ethynodiol diacetateThe serum concentration of Ethynodiol diacetate can be decreased when it is combined with Fosaprepitant.Approved
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Fosaprepitant.Approved, Investigational
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Fosaprepitant.Approved
EtoricoxibThe serum concentration of Etoricoxib can be increased when it is combined with Fosaprepitant.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Fosaprepitant.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Fosaprepitant.Approved
ExemestaneThe serum concentration of Exemestane can be increased when it is combined with Fosaprepitant.Approved, Investigational
FamciclovirThe serum concentration of Famciclovir can be increased when it is combined with Fosaprepitant.Approved
FelbamateThe serum concentration of Felbamate can be increased when it is combined with Fosaprepitant.Approved
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Fosaprepitant.Approved, Investigational
FenofibrateThe serum concentration of Fenofibrate can be increased when it is combined with Fosaprepitant.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Fosaprepitant.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Fosaprepitant.Approved
FinasterideThe serum concentration of Finasteride can be increased when it is combined with Fosaprepitant.Approved
FingolimodThe serum concentration of Fingolimod can be increased when it is combined with Fosaprepitant.Approved, Investigational
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Fosaprepitant.Approved
fluasteroneThe serum concentration of fluasterone can be increased when it is combined with Fosaprepitant.Investigational
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Fosaprepitant.Approved
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Fosaprepitant.Approved, Investigational
FlunitrazepamThe serum concentration of Flunitrazepam can be increased when it is combined with Fosaprepitant.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Fosaprepitant.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Fosaprepitant.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Fosaprepitant.Approved, Withdrawn
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Fosaprepitant.Approved
FluoxetineThe serum concentration of Fluoxetine can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Fosaprepitant.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Fosaprepitant.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Fosaprepitant.Approved
FlurazepamThe serum concentration of Flurazepam can be increased when it is combined with Fosaprepitant.Approved, Illicit
FlutamideThe serum concentration of Flutamide can be increased when it is combined with Fosaprepitant.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Fosaprepitant.Approved
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Fosaprepitant.Approved
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Fosaprepitant.Approved
FormestaneThe serum concentration of Formestane can be increased when it is combined with Fosaprepitant.Approved, Investigational, Withdrawn
FosamprenavirThe serum concentration of Fosamprenavir can be increased when it is combined with Fosaprepitant.Approved
FulvestrantThe serum concentration of Fulvestrant can be increased when it is combined with Fosaprepitant.Approved, Investigational
GalantamineThe serum concentration of Galantamine can be increased when it is combined with Fosaprepitant.Approved
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Fosaprepitant.Approved, Investigational
GemfibrozilThe serum concentration of Gemfibrozil can be increased when it is combined with Fosaprepitant.Approved
GestodeneThe serum concentration of Gestodene can be decreased when it is combined with Fosaprepitant.Approved
GlipizideThe serum concentration of Glipizide can be increased when it is combined with Fosaprepitant.Approved
GlyburideThe serum concentration of Glyburide can be increased when it is combined with Fosaprepitant.Approved
GranisetronThe serum concentration of Granisetron can be increased when it is combined with Fosaprepitant.Approved, Investigational
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Fosaprepitant.Withdrawn
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Fosaprepitant.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Fosaprepitant.Approved
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Fosaprepitant.Approved
HalothaneThe serum concentration of Halothane can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be increased when it is combined with Fosaprepitant.Investigational
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Fosaprepitant.Withdrawn
HexobarbitalThe serum concentration of Hexobarbital can be increased when it is combined with Fosaprepitant.Approved
Histamine PhosphateThe serum concentration of Histamine Phosphate can be increased when it is combined with Fosaprepitant.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Fosaprepitant.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
HydromorphoneThe serum concentration of Hydromorphone can be increased when it is combined with Fosaprepitant.Approved, Illicit
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Fosaprepitant.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Fosaprepitant.Approved
IfosfamideThe serum concentration of Ifosfamide can be increased when it is combined with Fosaprepitant.Approved
IloperidoneThe serum concentration of Iloperidone can be increased when it is combined with Fosaprepitant.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Fosaprepitant.Approved
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Fosaprepitant.Approved
ImiquimodThe serum concentration of Imiquimod can be increased when it is combined with Fosaprepitant.Approved, Investigational
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Fosaprepitant.Approved
IndapamideThe serum concentration of Indapamide can be increased when it is combined with Fosaprepitant.Approved
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Fosaprepitant.Approved
Ipratropium bromideThe serum concentration of Ipratropium bromide can be increased when it is combined with Fosaprepitant.Approved
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Fosaprepitant.Approved, Investigational
IsavuconazoniumThe serum concentration of Isavuconazonium can be increased when it is combined with Fosaprepitant.Approved, Investigational
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be increased when it is combined with Fosaprepitant.Approved
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be increased when it is combined with Fosaprepitant.Approved
IsradipineThe serum concentration of Isradipine can be increased when it is combined with Fosaprepitant.Approved
IstaroximeThe serum concentration of Istaroxime can be increased when it is combined with Fosaprepitant.Investigational
ItraconazoleThe serum concentration of Itraconazole can be increased when it is combined with Fosaprepitant.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Fosaprepitant.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Fosaprepitant.Approved
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Fosaprepitant.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be increased when it is combined with Fosaprepitant.Approved
KetamineThe serum concentration of Ketamine can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Fosaprepitant.Approved
KetobemidoneThe serum concentration of Ketobemidone can be increased when it is combined with Fosaprepitant.Approved
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Fosaprepitant.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Fosaprepitant.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Fosaprepitant.Approved, Investigational
LaquinimodThe serum concentration of Laquinimod can be increased when it is combined with Fosaprepitant.Investigational
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Fosaprepitant.Approved
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Fosaprepitant.Approved, Investigational
LetrozoleThe serum concentration of Letrozole can be increased when it is combined with Fosaprepitant.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Fosaprepitant.Approved
LevocetirizineThe serum concentration of Levocetirizine can be increased when it is combined with Fosaprepitant.Approved
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be increased when it is combined with Fosaprepitant.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Fosaprepitant.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Fosaprepitant.Approved, Investigational
LevothyroxineThe serum concentration of Levothyroxine can be increased when it is combined with Fosaprepitant.Approved
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
LisurideThe serum concentration of Lisuride can be increased when it is combined with Fosaprepitant.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Fosaprepitant.Approved
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Fosaprepitant.Approved
LopinavirThe serum concentration of Lopinavir can be increased when it is combined with Fosaprepitant.Approved
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Fosaprepitant.Approved
LorcaserinThe serum concentration of Lorcaserin can be increased when it is combined with Fosaprepitant.Approved
LosartanThe serum concentration of Losartan can be increased when it is combined with Fosaprepitant.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Fosaprepitant.Approved, Investigational
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Fosaprepitant.Approved
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Fosaprepitant.Approved
LynestrenolThe serum concentration of Lynestrenol can be decreased when it is combined with Fosaprepitant.Investigational
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Fosaprepitant.Approved
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Fosaprepitant.Approved, Investigational
ME-609The serum concentration of ME-609 can be increased when it is combined with Fosaprepitant.Investigational
MebendazoleThe serum concentration of Mebendazole can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Fosaprepitant.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Fosaprepitant.Approved
MefloquineThe serum concentration of Mefloquine can be increased when it is combined with Fosaprepitant.Approved
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Fosaprepitant.Vet Approved
MeloxicamThe serum concentration of Meloxicam can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Fosaprepitant.Approved
MethadoneThe serum concentration of Methadone can be increased when it is combined with Fosaprepitant.Approved
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Fosaprepitant.Experimental
MethaqualoneThe serum concentration of Methaqualone can be increased when it is combined with Fosaprepitant.Illicit, Withdrawn
MethoxsalenThe serum concentration of Methoxsalen can be increased when it is combined with Fosaprepitant.Approved
MethoxyfluraneThe serum concentration of Methoxyflurane can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
MethyltestosteroneThe serum concentration of Methyltestosterone can be increased when it is combined with Fosaprepitant.Approved
MetronidazoleThe serum concentration of Metronidazole can be increased when it is combined with Fosaprepitant.Approved
MexiletineThe serum concentration of Mexiletine can be increased when it is combined with Fosaprepitant.Approved
MianserinThe serum concentration of Mianserin can be increased when it is combined with Fosaprepitant.Approved
MibefradilThe serum concentration of Mibefradil can be increased when it is combined with Fosaprepitant.Withdrawn
MiconazoleThe serum concentration of Miconazole can be increased when it is combined with Fosaprepitant.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Fosaprepitant.Approved, Illicit
MifepristoneThe serum concentration of Mifepristone can be increased when it is combined with Fosaprepitant.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Fosaprepitant.Approved
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Fosaprepitant.Approved
ModafinilThe serum concentration of Modafinil can be increased when it is combined with Fosaprepitant.Approved, Investigational
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
MontelukastThe serum concentration of Montelukast can be increased when it is combined with Fosaprepitant.Approved
MorphineThe serum concentration of Morphine can be increased when it is combined with Fosaprepitant.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Fosaprepitant.Approved, Investigational
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Fosaprepitant.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Fosaprepitant.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be increased when it is combined with Fosaprepitant.Investigational
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Fosaprepitant.Approved, Withdrawn
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Fosaprepitant.Approved
NevirapineThe serum concentration of Nevirapine can be increased when it is combined with Fosaprepitant.Approved
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Fosaprepitant.Approved
NicotineThe serum concentration of Nicotine can be increased when it is combined with Fosaprepitant.Approved
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Fosaprepitant.Approved
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Fosaprepitant.Approved, Investigational
NilvadipineThe serum concentration of Nilvadipine can be increased when it is combined with Fosaprepitant.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Fosaprepitant.Approved
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Fosaprepitant.Approved
NitrazepamThe serum concentration of Nitrazepam can be increased when it is combined with Fosaprepitant.Approved
NitrendipineThe serum concentration of Nitrendipine can be increased when it is combined with Fosaprepitant.Approved
NorelgestrominThe serum concentration of Norelgestromin can be decreased when it is combined with Fosaprepitant.Approved
NorethisteroneThe serum concentration of Norethisterone can be increased when it is combined with Fosaprepitant.Approved
NorgestimateThe serum concentration of Norgestimate can be decreased when it is combined with Fosaprepitant.Approved
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Fosaprepitant.Approved
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Fosaprepitant.Approved
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Fosaprepitant.Approved
Oleoyl estroneThe serum concentration of Oleoyl estrone can be increased when it is combined with Fosaprepitant.Investigational
OlopatadineThe serum concentration of Olopatadine can be increased when it is combined with Fosaprepitant.Approved
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Fosaprepitant.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Fosaprepitant.Approved
OrphenadrineThe serum concentration of Orphenadrine can be increased when it is combined with Fosaprepitant.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Fosaprepitant.Approved
OxazepamThe serum concentration of Oxazepam can be increased when it is combined with Fosaprepitant.Approved
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Fosaprepitant.Approved, Investigational
OxycodoneThe serum concentration of Oxycodone can be increased when it is combined with Fosaprepitant.Approved, Illicit, Investigational
OxymorphoneThe serum concentration of Oxymorphone can be increased when it is combined with Fosaprepitant.Approved, Investigational, Vet Approved
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Fosaprepitant.Approved
PalonosetronThe serum concentration of Palonosetron can be increased when it is combined with Fosaprepitant.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Fosaprepitant.Approved, Investigational
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Fosaprepitant.Approved
ParamethadioneThe serum concentration of Paramethadione can be increased when it is combined with Fosaprepitant.Approved
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Fosaprepitant.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Fosaprepitant.Approved
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Fosaprepitant.Approved, Investigational
ParitaprevirThe serum concentration of Paritaprevir can be increased when it is combined with Fosaprepitant.Approved
ParoxetineThe serum concentration of the active metabolites of Fosaprepitant can be reduced when Fosaprepitant is used in combination with Paroxetine resulting in a loss in efficacy.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Fosaprepitant.Approved
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Fosaprepitant.Approved
PerampanelThe serum concentration of Perampanel can be increased when it is combined with Fosaprepitant.Approved
PergolideThe serum concentration of Pergolide can be increased when it is combined with Fosaprepitant.Approved, Vet Approved, Withdrawn
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Fosaprepitant.Approved
PermethrinThe serum concentration of Permethrin can be increased when it is combined with Fosaprepitant.Approved, Investigational
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Fosaprepitant.Approved
PethidineThe serum concentration of Pethidine can be increased when it is combined with Fosaprepitant.Approved
PhenacetinThe serum concentration of Phenacetin can be increased when it is combined with Fosaprepitant.Withdrawn
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be increased when it is combined with Fosaprepitant.Approved
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Fosaprepitant.Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
PilocarpineThe serum concentration of Pilocarpine can be increased when it is combined with Fosaprepitant.Approved
PimecrolimusThe serum concentration of Pimecrolimus can be increased when it is combined with Fosaprepitant.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Fosaprepitant.Approved
PinacidilThe serum concentration of Pinacidil can be increased when it is combined with Fosaprepitant.Withdrawn
PioglitazoneThe serum concentration of Pioglitazone can be increased when it is combined with Fosaprepitant.Approved, Investigational
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Fosaprepitant.Approved
PodofiloxThe serum concentration of Podofilox can be increased when it is combined with Fosaprepitant.Approved
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Fosaprepitant.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Fosaprepitant.Approved
PosaconazoleThe serum concentration of Posaconazole can be increased when it is combined with Fosaprepitant.Approved, Investigational, Vet Approved
PrasteroneThe serum concentration of Prasterone can be increased when it is combined with Fosaprepitant.Approved, Nutraceutical
PrasugrelThe serum concentration of Prasugrel can be increased when it is combined with Fosaprepitant.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Fosaprepitant.Approved
PrazepamThe serum concentration of Prazepam can be increased when it is combined with Fosaprepitant.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Fosaprepitant.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Fosaprepitant.Experimental
PrimaquineThe serum concentration of Primaquine can be increased when it is combined with Fosaprepitant.Approved
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
ProguanilThe serum concentration of Proguanil can be increased when it is combined with Fosaprepitant.Approved
PromazineThe serum concentration of Promazine can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Fosaprepitant.Approved
PropofolThe serum concentration of Propofol can be increased when it is combined with Fosaprepitant.Approved, Investigational, Vet Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Fosaprepitant.Approved, Investigational
PyrazinamideThe serum concentration of Pyrazinamide can be increased when it is combined with Fosaprepitant.Approved
QuazepamThe serum concentration of Quazepam can be increased when it is combined with Fosaprepitant.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Fosaprepitant.Approved
QuinacrineThe serum concentration of Quinacrine can be increased when it is combined with Fosaprepitant.Approved
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Fosaprepitant.Approved
QuinineThe serum concentration of Quinine can be increased when it is combined with Fosaprepitant.Approved
RabeprazoleThe serum concentration of Rabeprazole can be increased when it is combined with Fosaprepitant.Approved, Investigational
RaloxifeneThe serum concentration of Raloxifene can be increased when it is combined with Fosaprepitant.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Fosaprepitant.Approved, Investigational
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Fosaprepitant.Approved, Investigational
ReboxetineThe serum concentration of Reboxetine can be increased when it is combined with Fosaprepitant.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Fosaprepitant.Approved
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Fosaprepitant.Approved, Investigational
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Fosaprepitant.Approved
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Fosaprepitant.Approved
RifampicinThe serum concentration of Fosaprepitant can be decreased when it is combined with Rifampicin.Approved
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Fosaprepitant.Approved
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Fosaprepitant.Approved
RimonabantThe serum concentration of Rimonabant can be increased when it is combined with Fosaprepitant.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Fosaprepitant.Approved
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Fosaprepitant.Approved, Investigational
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Fosaprepitant.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Fosaprepitant.Approved
RofecoxibThe serum concentration of Rofecoxib can be increased when it is combined with Fosaprepitant.Investigational, Withdrawn
RolapitantThe serum concentration of Rolapitant can be increased when it is combined with Fosaprepitant.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Fosaprepitant.Approved, Investigational
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Fosaprepitant.Approved, Investigational
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Fosaprepitant.Approved
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Fosaprepitant.Approved
RotigotineThe serum concentration of Rotigotine can be increased when it is combined with Fosaprepitant.Approved
RoxithromycinThe serum concentration of Roxithromycin can be increased when it is combined with Fosaprepitant.Approved, Withdrawn
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Fosaprepitant.Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Fosaprepitant.Approved
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Fosaprepitant.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Fosaprepitant.Approved
SelegilineThe serum concentration of Selegiline can be increased when it is combined with Fosaprepitant.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Fosaprepitant.Approved
SeratrodastThe serum concentration of Seratrodast can be increased when it is combined with Fosaprepitant.Approved, Investigational
SertindoleThe serum concentration of Sertindole can be increased when it is combined with Fosaprepitant.Approved, Withdrawn
SertralineThe serum concentration of Sertraline can be increased when it is combined with Fosaprepitant.Approved
SevofluraneThe serum concentration of Sevoflurane can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
SibutramineThe serum concentration of Sibutramine can be increased when it is combined with Fosaprepitant.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Fosaprepitant.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Fosaprepitant.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Fosaprepitant.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Fosaprepitant.Approved
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Fosaprepitant.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Fosaprepitant.Approved, Investigational
SolifenacinThe serum concentration of Solifenacin can be increased when it is combined with Fosaprepitant.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Fosaprepitant.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Fosaprepitant.Approved, Investigational
SpiramycinThe serum concentration of Spiramycin can be increased when it is combined with Fosaprepitant.Approved
SufentanilThe serum concentration of Sufentanil can be increased when it is combined with Fosaprepitant.Approved, Investigational
SulfadiazineThe serum concentration of Sulfadiazine can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be increased when it is combined with Fosaprepitant.Approved
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be increased when it is combined with Fosaprepitant.Approved
SunitinibThe serum concentration of Sunitinib can be increased when it is combined with Fosaprepitant.Approved, Investigational
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Fosaprepitant.Approved
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be increased when it is combined with Fosaprepitant.Approved
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Fosaprepitant.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Fosaprepitant.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Fosaprepitant.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Fosaprepitant.Approved, Investigational
TasosartanThe serum concentration of Tasosartan can be increased when it is combined with Fosaprepitant.Approved
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be increased when it is combined with Fosaprepitant.Experimental
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Fosaprepitant.Approved
TelithromycinThe serum concentration of Telithromycin can be increased when it is combined with Fosaprepitant.Approved
TemazepamThe serum concentration of Temazepam can be increased when it is combined with Fosaprepitant.Approved
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Fosaprepitant.Approved
TeniposideThe serum concentration of Teniposide can be increased when it is combined with Fosaprepitant.Approved
TerbinafineThe serum concentration of Terbinafine can be increased when it is combined with Fosaprepitant.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Fosaprepitant.Withdrawn
TesmilifeneThe serum concentration of Tesmilifene can be increased when it is combined with Fosaprepitant.Investigational
TestosteroneThe serum concentration of Testosterone can be increased when it is combined with Fosaprepitant.Approved, Investigational
TetracyclineThe serum concentration of Tetracycline can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Fosaprepitant.Approved
ThiotepaThe serum concentration of Thiotepa can be increased when it is combined with Fosaprepitant.Approved
TiagabineThe serum concentration of Tiagabine can be increased when it is combined with Fosaprepitant.Approved
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Fosaprepitant.Approved
TiclopidineThe serum concentration of Ticlopidine can be increased when it is combined with Fosaprepitant.Approved
TinidazoleThe serum concentration of Tinidazole can be increased when it is combined with Fosaprepitant.Approved, Investigational
TiotropiumThe serum concentration of Tiotropium can be increased when it is combined with Fosaprepitant.Approved
TipranavirThe serum concentration of Tipranavir can be increased when it is combined with Fosaprepitant.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Fosaprepitant.Approved
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Fosaprepitant.Approved, Investigational
TolbutamideThe serum concentration of Tolbutamide can be decreased when it is combined with Fosaprepitant.Approved
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Fosaprepitant.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Fosaprepitant.Approved
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Fosaprepitant.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Fosaprepitant.Approved, Investigational
TramadolThe serum concentration of Tramadol can be increased when it is combined with Fosaprepitant.Approved, Investigational
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Fosaprepitant.Approved
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Fosaprepitant.Approved, Investigational
TretinoinThe serum concentration of Tretinoin can be increased when it is combined with Fosaprepitant.Approved, Investigational, Nutraceutical
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Fosaprepitant.Approved
TrimethadioneThe serum concentration of Trimethadione can be increased when it is combined with Fosaprepitant.Approved
TrimethoprimThe serum concentration of Trimethoprim can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Fosaprepitant.Approved
TroglitazoneThe serum concentration of Troglitazone can be increased when it is combined with Fosaprepitant.Withdrawn
TroleandomycinThe serum concentration of Troleandomycin can be increased when it is combined with Fosaprepitant.Approved
UdenafilThe serum concentration of Udenafil can be increased when it is combined with Fosaprepitant.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Fosaprepitant.Approved
ValdecoxibThe serum concentration of Valdecoxib can be increased when it is combined with Fosaprepitant.Investigational, Withdrawn
VandetanibThe serum concentration of Vandetanib can be increased when it is combined with Fosaprepitant.Approved
VanoxerineThe serum concentration of Vanoxerine can be increased when it is combined with Fosaprepitant.Investigational
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Fosaprepitant.Approved
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Fosaprepitant.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Fosaprepitant.Approved
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Fosaprepitant.Approved
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Fosaprepitant.Approved
VicrivirocThe serum concentration of Vicriviroc can be increased when it is combined with Fosaprepitant.Investigational
VilanterolThe serum concentration of Vilanterol can be increased when it is combined with Fosaprepitant.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Fosaprepitant.Approved
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Fosaprepitant.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Fosaprepitant.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Fosaprepitant.Approved
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Fosaprepitant.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Fosaprepitant.Approved
VoriconazoleThe serum concentration of Voriconazole can be increased when it is combined with Fosaprepitant.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Fosaprepitant.Approved
WarfarinThe serum concentration of Warfarin can be decreased when it is combined with Fosaprepitant.Approved
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Fosaprepitant.Approved, Vet Approved
ZafirlukastThe serum concentration of Zafirlukast can be increased when it is combined with Fosaprepitant.Approved, Investigational
ZalcitabineThe serum concentration of Zalcitabine can be increased when it is combined with Fosaprepitant.Approved
ZaleplonThe serum concentration of Zaleplon can be increased when it is combined with Fosaprepitant.Approved, Illicit, Investigational
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Fosaprepitant.Approved
ZileutonThe serum concentration of Zileuton can be increased when it is combined with Fosaprepitant.Approved, Investigational, Withdrawn
ZiprasidoneThe serum concentration of Ziprasidone can be increased when it is combined with Fosaprepitant.Approved
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Fosaprepitant.Approved
ZomepiracThe serum concentration of Zomepirac can be increased when it is combined with Fosaprepitant.Withdrawn
ZonisamideThe serum concentration of Zonisamide can be increased when it is combined with Fosaprepitant.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Fosaprepitant.Approved
Food InteractionsNot Available
References
Synthesis Reference

Navin Ganesh Bhatt, Nikhil Rasiklal Trivedi, Mahesh Khedekar, Sukumar Sinha, Mubeen Ahmed Khan, Ramjilal Yadav, “FOSAPREPITANT DIMEGLUMINE INTERMEDIATE, NEUTRAL FOSAPREPITANT, AND AMORPHOUS FOSAPREPITANT DIMEGLUMINE AND PROCESSES FOR THEIR PREPARATIONS.” U.S. Patent US20110130366, issued June 02, 2011.

US20110130366
General ReferencesNot Available
External Links
ATC CodesNot Available
AHFS Codes
  • 56:22.92
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.5225
Blood Brain Barrier-0.81
Caco-2 permeable-0.6534
P-glycoprotein substrateSubstrate0.8255
P-glycoprotein inhibitor INon-inhibitor0.6532
P-glycoprotein inhibitor IINon-inhibitor0.986
Renal organic cation transporterNon-inhibitor0.8583
CYP450 2C9 substrateNon-substrate0.7018
CYP450 2D6 substrateNon-substrate0.8588
CYP450 3A4 substrateSubstrate0.546
CYP450 1A2 substrateNon-inhibitor0.7539
CYP450 2C9 inhibitorNon-inhibitor0.644
CYP450 2D6 inhibitorNon-inhibitor0.8521
CYP450 2C19 inhibitorNon-inhibitor0.6705
CYP450 3A4 inhibitorInhibitor0.6258
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.5
Ames testNon AMES toxic0.5349
CarcinogenicityNon-carcinogens0.7701
BiodegradationNot ready biodegradable0.9899
Rat acute toxicity2.6064 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.5
hERG inhibition (predictor II)Inhibitor0.6528
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
Injection, powder, lyophilized, for solutionIntravenous115 mg/5mL
Injection, powder, lyophilized, for solutionIntravenous150 mg/5mL
Powder, for solutionIntravenous115 mg
Powder, for solutionIntravenous150 mg
Injection, powder, for solutionIntravenous150 mg
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US5691336 No1999-03-042019-03-04Us
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.00632 mg/mLALOGPS
logP2.89ALOGPS
logP2.4ChemAxon
logS-5ALOGPS
pKa (Strongest Acidic)1.02ChemAxon
pKa (Strongest Basic)5.69ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count9ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area123.93 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity138.63 m3·mol-1ChemAxon
Polarizability49.92 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylmorpholines. These are aromatic compounds containing a morpholine ring and a benzene ring linked to each other through a CC or a CN bond.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassOxazinanes
Sub ClassMorpholines
Direct ParentPhenylmorpholines
Alternative Parents
Substituents
  • Phenylmorpholine
  • Aralkylamine
  • Halobenzene
  • Fluorobenzene
  • Benzenoid
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl fluoride
  • Heteroaromatic compound
  • 1,2,4-triazole
  • Azole
  • Tertiary aliphatic amine
  • Tertiary amine
  • Oxacycle
  • Azacycle
  • Acetal
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organofluoride
  • Organohalogen compound
  • Amine
  • Alkyl halide
  • Alkyl fluoride
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Comments
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Drug created on May 16, 2010 18:16 / Updated on December 07, 2016 02:37