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Identification
NameAprepitant
Accession NumberDB00673  (APRD00100)
TypeSmall Molecule
GroupsApproved, Investigational
DescriptionAprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting (CI NV).
Structure
Thumb
Synonyms
3-(((2R,3S)-3-(P-Fluorophenyl)-2-(((alphar)-alpha-methyl-3,5-bis(trifluoromethyl)benzyl)oxy)morpholino)methyl)-delta(2)-1,2,4-triazolin-5-one
Aprepitant
Aprépitant
Aprepitantum
External Identifiers
  • L 754030
  • L-754939
  • MK-0517
  • MK-869
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
EmendPowder, for suspension125 mg/1OralMerck Sharp & Dohme Corp.2015-12-17Not applicableUs
EmendCapsule80 mg/1OralMerck Sharp & Dohme Corp.2003-03-26Not applicableUs
EmendCapsule40 mgOralMerck Sharp & Dohme Ltd.2003-11-11Not applicableEu
EmendCapsule80 mgOralMerck Sharp & Dohme Ltd.2003-11-11Not applicableEu
EmendCapsule40 mg/1OralRebel Distributors Corp2003-03-26Not applicableUs
EmendPowder, for suspension125 mgOralMerck Sharp & Dohme Ltd.2003-11-11Not applicableEu
EmendCapsule80 mgOralMerck Canada Inc2007-09-24Not applicableCanada
EmendCapsule125 mg/1OralMerck Sharp & Dohme Corp.2003-03-26Not applicableUs
EmendCapsule40 mgOralMerck Sharp & Dohme Ltd.2003-11-11Not applicableEu
EmendCapsule80 mgOralMerck Sharp & Dohme Ltd.2003-11-11Not applicableEu
EmendCapsule80 mg/1OralPhysicians Total Care, Inc.2005-06-29Not applicableUs
EmendCapsule125 mgOralMerck Canada Inc2007-09-24Not applicableCanada
EmendCapsule40 mg/1OralMerck Sharp & Dohme Corp.2003-03-26Not applicableUs
EmendCapsule165 mgOralMerck Sharp & Dohme Ltd.2003-11-11Not applicableEu
EmendCapsule125 mgOralMerck Sharp & Dohme Ltd.2003-11-11Not applicableEu
EmendKitPhysicians Total Care, Inc.2005-06-24Not applicableUs
EmendCapsule80 mgOralMerck Sharp & Dohme Ltd.2003-11-11Not applicableEu
EmendCapsule165 mgOralMerck Sharp & Dohme Ltd.2003-11-11Not applicableEu
EmendKitMerck Sharp & Dohme Corp.2003-03-26Not applicableUs
EmendCapsule125 mgOralMerck Sharp & Dohme Ltd.2003-11-11Not applicableEu
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
AprepitantCapsule40 mg/1OralSandoz Inc2016-12-09Not applicableUs
AprepitantCapsule80 mg/1OralSandoz Inc2016-12-09Not applicableUs
AprepitantCapsule125 mg/1OralSandoz Inc2016-12-09Not applicableUs
AprepitantKitSandoz Inc2016-12-09Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AprecapGlenmark
Brand mixtures
NameLabellerIngredients
Emend Tri-packMerck Canada Inc
SaltsNot Available
Categories
UNII1NF15YR6UY
CAS number170729-80-3
WeightAverage: 534.4267
Monoisotopic: 534.150187993
Chemical FormulaC23H21F7N4O3
InChI KeyATALOFNDEOCMKK-OITMNORJSA-N
InChI
InChI=1S/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1
IUPAC Name
3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-4,5-dihydro-1H-1,2,4-triazol-5-one
SMILES
C[C@@H](O[[email protected]]1OCCN(CC2=NNC(=O)N2)[[email protected]]1C1=CC=C(F)C=C1)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F
Pharmacology
IndicationFor the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy, including high-dose cisplatin (in combination with other antiemetic agents).
Structured Indications
PharmacodynamicsAprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting (CI NV).
Mechanism of actionAprepitant has been shown in animal models to inhibit emesis induced by cytotoxic chemotherapeutic agents, such as cisplatin, via central actions. Animal and human Positron Emission Tomography (PET) studies with Aprepitant have shown that it crosses the blood brain barrier and occupies brain NK1 receptors. Animal and human studies show that Aprepitant augments the antiemetic activity of the 5-HT3-receptor antagonist ondansetron and the corticosteroid ethasone and inhibits both the acute and delayed phases of cisplatin induced emesis.
TargetKindPharmacological actionActionsOrganismUniProt ID
Substance-P receptorProteinyes
antagonist
HumanP25103 details
Related Articles
AbsorptionThe mean absolute oral bioavailability of aprepitant is approximately 60 to 65%.
Volume of distribution
  • 70 L
Protein binding>95%
Metabolism

Aprepitant is metabolized primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19. Seven metabolites of aprepitant, which are only weakly active, have been identified in human plasma.

SubstrateEnzymesProduct
Aprepitant
(2S,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholineDetails
Aprepitant
5-({[(1R)-1-(4-fluorophenyl)-2-hydroxyethyl]amino}methyl)-2,3-dihydro-1H-1,2,4-triazol-3-oneDetails
Aprepitant
(2R)-2-(4-fluorophenyl)-2-{[(5-oxo-2,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]amino}acetic acidDetails
Route of eliminationAprepitant is eliminated primarily by metabolism; aprepitant is not renally excreted. Aprepitant is excreted in the milk of rats. It is not known whether this drug is excreted in human milk.
Half life9-13 hours
Clearance
  • Apparent plasma cl=62-90 mL/min
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be increased when it is combined with Aprepitant.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be increased when it is combined with Aprepitant.Experimental, Illicit
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be increased when it is combined with Aprepitant.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be increased when it is combined with Aprepitant.Experimental, Illicit
AbirateroneThe serum concentration of Aprepitant can be increased when it is combined with Abiraterone.Approved
AceclofenacThe metabolism of Aceclofenac can be increased when combined with Aprepitant.Approved
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Aprepitant.Approved
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Aprepitant.Approved
Acetylsalicylic acidThe metabolism of Acetylsalicylic acid can be increased when combined with Aprepitant.Approved, Vet Approved
AdinazolamThe serum concentration of Adinazolam can be increased when it is combined with Aprepitant.Approved
AlbendazoleThe serum concentration of Albendazole can be increased when it is combined with Aprepitant.Approved, Vet Approved
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Aprepitant.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Aprepitant.Experimental
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Aprepitant.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Aprepitant.Approved, Investigational
AliskirenThe serum concentration of Aliskiren can be increased when it is combined with Aprepitant.Approved, Investigational
AllylestrenolThe serum concentration of Allylestrenol can be increased when it is combined with Aprepitant.Approved
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Aprepitant.Approved, Investigational
AlogliptinThe serum concentration of Alogliptin can be increased when it is combined with Aprepitant.Approved
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Aprepitant.Approved, Withdrawn
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Aprepitant.Approved, Illicit, Investigational
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Aprepitant.Approved, Investigational
AmbroxolThe serum concentration of Ambroxol can be increased when it is combined with Aprepitant.Approved
AmcinonideThe serum concentration of Amcinonide can be increased when it is combined with Aprepitant.Approved
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Aprepitant.Approved, Withdrawn
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Aprepitant.Approved
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Aprepitant.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Aprepitant.Approved
AmlodipineThe serum concentration of Amlodipine can be increased when it is combined with Aprepitant.Approved
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Aprepitant.Approved
AnecortaveThe serum concentration of Anecortave can be increased when it is combined with Aprepitant.Investigational
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Aprepitant.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Aprepitant.Approved
ApremilastThe serum concentration of Apremilast can be increased when it is combined with Aprepitant.Approved, Investigational
Arachidonic AcidThe metabolism of Arachidonic Acid can be increased when combined with Aprepitant.Experimental
ArformoterolThe metabolism of Arformoterol can be increased when combined with Aprepitant.Approved, Investigational
ArgatrobanThe serum concentration of Argatroban can be increased when it is combined with Aprepitant.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Aprepitant.Approved, Investigational
ArmodafinilThe metabolism of Aprepitant can be decreased when combined with Armodafinil.Approved, Investigational
ArtemetherThe serum concentration of Artemether can be increased when it is combined with Aprepitant.Approved
AsenapineThe serum concentration of Asenapine can be increased when it is combined with Aprepitant.Approved
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Aprepitant.Approved, Withdrawn
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Aprepitant.Approved, Investigational
AtomoxetineThe metabolism of Aprepitant can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe serum concentration of Atorvastatin can be increased when it is combined with Aprepitant.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Aprepitant.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Aprepitant.Approved, Investigational
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Aprepitant.Approved
AzithromycinThe serum concentration of Azithromycin can be increased when it is combined with Aprepitant.Approved
BanoxantroneThe serum concentration of Banoxantrone can be increased when it is combined with Aprepitant.Investigational
BeclomethasoneThe serum concentration of Beclomethasone can be increased when it is combined with Aprepitant.Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be increased when it is combined with Aprepitant.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Aprepitant.Approved
BenzphetamineThe serum concentration of Benzphetamine can be increased when it is combined with Aprepitant.Approved, Illicit
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Aprepitant.Approved
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Aprepitant.Approved, Vet Approved
BexaroteneThe serum concentration of Bexarotene can be increased when it is combined with Aprepitant.Approved, Investigational
BezafibrateThe serum concentration of Bezafibrate can be increased when it is combined with Aprepitant.Approved
BicalutamideThe serum concentration of Bicalutamide can be increased when it is combined with Aprepitant.Approved
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Aprepitant.Approved
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Aprepitant.Approved
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Aprepitant.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Aprepitant.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Aprepitant.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Aprepitant.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Aprepitant.Approved
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Aprepitant.Approved
BromazepamThe serum concentration of Bromazepam can be increased when it is combined with Aprepitant.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Aprepitant.Approved, Investigational
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Aprepitant.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Aprepitant.Approved
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Aprepitant.Approved, Investigational
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Aprepitant.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be increased when it is combined with Aprepitant.Approved
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Aprepitant.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Aprepitant.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Aprepitant.Approved
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Aprepitant.Approved
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Aprepitant.Approved
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Aprepitant.Approved
CalcitriolThe serum concentration of Calcitriol can be increased when it is combined with Aprepitant.Approved, Nutraceutical
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Aprepitant.Approved
CandesartanThe metabolism of Candesartan can be increased when combined with Aprepitant.Approved
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Aprepitant.Approved, Investigational
CarbinoxamineThe serum concentration of Carbinoxamine can be increased when it is combined with Aprepitant.Approved
CariprazineThe serum concentration of Cariprazine can be increased when it is combined with Aprepitant.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Aprepitant.Approved, Investigational
CelecoxibThe serum concentration of Celecoxib can be increased when it is combined with Aprepitant.Approved, Investigational
CeliprololThe serum concentration of Celiprolol can be increased when it is combined with Aprepitant.Approved, Investigational
CephalexinThe serum concentration of Cephalexin can be increased when it is combined with Aprepitant.Approved, Vet Approved
CeritinibThe serum concentration of Aprepitant can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Aprepitant.Withdrawn
CevimelineThe serum concentration of Cevimeline can be increased when it is combined with Aprepitant.Approved
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be increased when it is combined with Aprepitant.Approved
ChloramphenicolThe metabolism of Aprepitant can be decreased when combined with Chloramphenicol.Approved, Vet Approved
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Aprepitant.Approved, Illicit
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Aprepitant.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Chlorotrianisene can be decreased when it is combined with Aprepitant.Withdrawn
ChlorphenamineThe serum concentration of Chlorphenamine can be increased when it is combined with Aprepitant.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Aprepitant.Approved, Vet Approved
ChlorpropamideThe metabolism of Chlorpropamide can be increased when combined with Aprepitant.Approved
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Aprepitant.Approved
CholecalciferolThe serum concentration of Cholecalciferol can be increased when it is combined with Aprepitant.Approved, Nutraceutical
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Aprepitant.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Aprepitant.Approved
CimetidineThe metabolism of Aprepitant can be decreased when combined with Cimetidine.Approved
CinacalcetThe serum concentration of Cinacalcet can be increased when it is combined with Aprepitant.Approved
CinnarizineThe metabolism of Cinnarizine can be increased when combined with Aprepitant.Approved
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Aprepitant.Approved, Investigational, Withdrawn
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Aprepitant.Approved
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Aprepitant.Approved
ClemastineThe metabolism of Aprepitant can be decreased when combined with Clemastine.Approved
ClindamycinThe serum concentration of Clindamycin can be increased when it is combined with Aprepitant.Approved, Vet Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Aprepitant.Approved, Illicit
ClobetasolThe serum concentration of Clobetasol can be increased when it is combined with Aprepitant.Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be increased when it is combined with Aprepitant.Approved
ClocortoloneThe serum concentration of Clocortolone can be increased when it is combined with Aprepitant.Approved
ClofazimineThe serum concentration of Clofazimine can be increased when it is combined with Aprepitant.Approved, Investigational
ClofibrateThe serum concentration of Clofibrate can be increased when it is combined with Aprepitant.Approved
clomethiazoleThe serum concentration of clomethiazole can be increased when it is combined with Aprepitant.Investigational
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Aprepitant.Approved, Vet Approved
ClonazepamThe serum concentration of Clonazepam can be increased when it is combined with Aprepitant.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Aprepitant.Approved
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Aprepitant.Approved, Nutraceutical
ClorazepateThe serum concentration of Clorazepate can be increased when it is combined with Aprepitant.Approved, Illicit
ClotiazepamThe serum concentration of Clotiazepam can be increased when it is combined with Aprepitant.Approved, Illicit
ClotrimazoleThe metabolism of Aprepitant can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Aprepitant.Approved
CobicistatThe metabolism of Aprepitant can be decreased when combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Aprepitant.Approved
CocaineThe serum concentration of Cocaine can be increased when it is combined with Aprepitant.Approved, Illicit
CodeineThe serum concentration of Codeine can be increased when it is combined with Aprepitant.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Aprepitant.Approved
ConivaptanThe serum concentration of Aprepitant can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Aprepitant.Approved
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Aprepitant.Approved
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Aprepitant.Approved
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Aprepitant.Approved
CyclophosphamideThe serum concentration of Cyclophosphamide can be increased when it is combined with Aprepitant.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Aprepitant.Approved, Investigational, Vet Approved
Cyproterone acetateThe serum concentration of Aprepitant can be decreased when it is combined with Cyproterone acetate.Approved, Investigational
CytarabineThe serum concentration of Cytarabine can be increased when it is combined with Aprepitant.Approved, Investigational
DabrafenibThe serum concentration of Aprepitant can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Aprepitant.Approved
DantroleneThe serum concentration of Dantrolene can be increased when it is combined with Aprepitant.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Aprepitant.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Aprepitant.Investigational
DapsoneThe serum concentration of Dapsone can be increased when it is combined with Aprepitant.Approved, Investigational
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Aprepitant.Approved, Investigational
DarunavirThe serum concentration of Darunavir can be increased when it is combined with Aprepitant.Approved
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Aprepitant.Approved
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Aprepitant.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Aprepitant.Approved
DeferasiroxThe serum concentration of Aprepitant can be decreased when it is combined with Deferasirox.Approved, Investigational
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Aprepitant.Investigational
DelavirdineThe serum concentration of Delavirdine can be increased when it is combined with Aprepitant.Approved
DesogestrelThe serum concentration of Desogestrel can be decreased when it is combined with Aprepitant.Approved
DesoximetasoneThe serum concentration of Desoximetasone can be increased when it is combined with Aprepitant.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be increased when it is combined with Aprepitant.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be increased when it is combined with Aprepitant.Experimental, Vet Approved
DesvenlafaxineThe serum concentration of Desvenlafaxine can be increased when it is combined with Aprepitant.Approved
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Aprepitant.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Aprepitant.Vet Approved
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Aprepitant.Approved
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be increased when it is combined with Aprepitant.Approved, Illicit, Withdrawn
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Aprepitant.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be decreased when it is combined with Aprepitant.Approved, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Aprepitant.Approved, Vet Approved
DicoumarolThe metabolism of Dicoumarol can be increased when combined with Aprepitant.Approved
DienestrolThe serum concentration of Dienestrol can be decreased when it is combined with Aprepitant.Approved
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Aprepitant.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Aprepitant.Approved
DiflorasoneThe serum concentration of Diflorasone can be increased when it is combined with Aprepitant.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be increased when it is combined with Aprepitant.Approved
DifluprednateThe serum concentration of Difluprednate can be increased when it is combined with Aprepitant.Approved
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Aprepitant.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Aprepitant.Approved
DihydrocodeineThe serum concentration of Dihydrocodeine can be increased when it is combined with Aprepitant.Approved, Illicit
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Aprepitant.Approved
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Aprepitant.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be increased when combined with Aprepitant.Approved
DisopyramideThe serum concentration of Disopyramide can be increased when it is combined with Aprepitant.Approved
DisulfiramThe serum concentration of Disulfiram can be increased when it is combined with Aprepitant.Approved
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Aprepitant.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Aprepitant.Approved
DolasetronThe serum concentration of Dolasetron can be increased when it is combined with Aprepitant.Approved
DomperidoneThe serum concentration of Domperidone can be increased when it is combined with Aprepitant.Approved, Investigational, Vet Approved
DonepezilThe serum concentration of Donepezil can be increased when it is combined with Aprepitant.Approved
DopamineThe metabolism of Dopamine can be increased when combined with Aprepitant.Approved
DorzolamideThe serum concentration of Dorzolamide can be increased when it is combined with Aprepitant.Approved
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Aprepitant.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Aprepitant.Approved, Investigational
DoxycyclineThe metabolism of Aprepitant can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Aprepitant.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Aprepitant.Approved
DrospirenoneThe serum concentration of Drospirenone can be decreased when it is combined with Aprepitant.Approved
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Aprepitant.Approved, Investigational
EfavirenzThe serum concentration of Efavirenz can be increased when it is combined with Aprepitant.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Aprepitant.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Aprepitant.Approved
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Aprepitant.Approved
EnalaprilThe serum concentration of Enalapril can be increased when it is combined with Aprepitant.Approved, Vet Approved
EnzalutamideThe serum concentration of Aprepitant can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Aprepitant.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Aprepitant.Approved
EpoprostenolThe metabolism of Epoprostenol can be increased when combined with Aprepitant.Approved
EquileninThe serum concentration of Equilenin can be increased when it is combined with Aprepitant.Experimental
EquilinThe serum concentration of Equilin can be increased when it is combined with Aprepitant.Approved
ErgocalciferolThe serum concentration of Ergocalciferol can be increased when it is combined with Aprepitant.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Aprepitant.Approved
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Aprepitant.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Aprepitant.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Aprepitant.Approved, Investigational
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Aprepitant.Approved, Vet Approved
EscitalopramThe serum concentration of Escitalopram can be increased when it is combined with Aprepitant.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Aprepitant can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsomeprazoleThe serum concentration of Esomeprazole can be increased when it is combined with Aprepitant.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Aprepitant.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Aprepitant.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be increased when it is combined with Aprepitant.Approved
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Aprepitant.Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be decreased when it is combined with Aprepitant.Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Aprepitant.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Aprepitant.Approved
EszopicloneThe serum concentration of Eszopiclone can be increased when it is combined with Aprepitant.Approved
EthanolThe serum concentration of Ethanol can be increased when it is combined with Aprepitant.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Aprepitant.Approved
EthosuximideThe serum concentration of Ethosuximide can be increased when it is combined with Aprepitant.Approved
EthylmorphineThe serum concentration of Ethylmorphine can be increased when it is combined with Aprepitant.Approved, Illicit
Ethynodiol diacetateThe serum concentration of Ethynodiol diacetate can be decreased when it is combined with Aprepitant.Approved
EtodolacThe metabolism of Etodolac can be increased when combined with Aprepitant.Approved, Investigational, Vet Approved
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Aprepitant.Approved, Investigational
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Aprepitant.Approved
EtoricoxibThe serum concentration of Etoricoxib can be increased when it is combined with Aprepitant.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Aprepitant.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Aprepitant.Approved
ExemestaneThe serum concentration of Exemestane can be increased when it is combined with Aprepitant.Approved, Investigational
FamciclovirThe serum concentration of Famciclovir can be increased when it is combined with Aprepitant.Approved
FelbamateThe serum concentration of Felbamate can be increased when it is combined with Aprepitant.Approved
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Aprepitant.Approved, Investigational
FenofibrateThe serum concentration of Fenofibrate can be increased when it is combined with Aprepitant.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Aprepitant.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Aprepitant.Approved
FinasterideThe serum concentration of Finasteride can be increased when it is combined with Aprepitant.Approved
FingolimodThe serum concentration of Fingolimod can be increased when it is combined with Aprepitant.Approved, Investigational
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Aprepitant.Approved
fluasteroneThe serum concentration of fluasterone can be increased when it is combined with Aprepitant.Investigational
FluconazoleThe metabolism of Aprepitant can be decreased when combined with Fluconazole.Approved
FludrocortisoneThe serum concentration of Fludrocortisone can be increased when it is combined with Aprepitant.Approved
FlumethasoneThe serum concentration of Flumethasone can be increased when it is combined with Aprepitant.Approved, Vet Approved
FlunarizineThe metabolism of Flunarizine can be increased when combined with Aprepitant.Approved
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Aprepitant.Approved, Investigational
FlunitrazepamThe serum concentration of Flunitrazepam can be increased when it is combined with Aprepitant.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be increased when it is combined with Aprepitant.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be increased when it is combined with Aprepitant.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be increased when it is combined with Aprepitant.Approved, Withdrawn
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Aprepitant.Approved
FluoxetineThe serum concentration of Fluoxetine can be increased when it is combined with Aprepitant.Approved, Vet Approved
FluprednideneThe serum concentration of Fluprednidene can be increased when it is combined with Aprepitant.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be increased when it is combined with Aprepitant.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be increased when it is combined with Aprepitant.Approved
FlurazepamThe serum concentration of Flurazepam can be increased when it is combined with Aprepitant.Approved, Illicit
FlurbiprofenThe metabolism of Flurbiprofen can be increased when combined with Aprepitant.Approved, Investigational
FlutamideThe serum concentration of Flutamide can be increased when it is combined with Aprepitant.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Aprepitant.Approved
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be increased when it is combined with Aprepitant.Approved
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Aprepitant.Approved
FluvoxamineThe metabolism of Aprepitant can be decreased when combined with Fluvoxamine.Approved, Investigational
FormestaneThe serum concentration of Formestane can be increased when it is combined with Aprepitant.Approved, Investigational, Withdrawn
FormoterolThe metabolism of Formoterol can be increased when combined with Aprepitant.Approved, Investigational
FosamprenavirThe serum concentration of Fosamprenavir can be increased when it is combined with Aprepitant.Approved
FosaprepitantThe serum concentration of Aprepitant can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Aprepitant can be increased when combined with Fosphenytoin.Approved
FulvestrantThe serum concentration of Fulvestrant can be increased when it is combined with Aprepitant.Approved, Investigational
Fusidic AcidThe serum concentration of Aprepitant can be increased when it is combined with Fusidic Acid.Approved
GalantamineThe serum concentration of Galantamine can be increased when it is combined with Aprepitant.Approved
GavestinelThe metabolism of Gavestinel can be increased when combined with Aprepitant.Investigational
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Aprepitant.Approved, Investigational
GemfibrozilThe serum concentration of Gemfibrozil can be increased when it is combined with Aprepitant.Approved
GestodeneThe serum concentration of Gestodene can be decreased when it is combined with Aprepitant.Approved
GliclazideThe metabolism of Gliclazide can be increased when combined with Aprepitant.Approved
GlimepirideThe metabolism of Glimepiride can be increased when combined with Aprepitant.Approved
GlipizideThe serum concentration of Glipizide can be increased when it is combined with Aprepitant.Approved
GlyburideThe serum concentration of Glyburide can be increased when it is combined with Aprepitant.Approved
GranisetronThe serum concentration of Granisetron can be increased when it is combined with Aprepitant.Approved, Investigational
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Aprepitant.Withdrawn
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Aprepitant.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Aprepitant.Approved
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Aprepitant.Approved
HalothaneThe serum concentration of Halothane can be increased when it is combined with Aprepitant.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be increased when it is combined with Aprepitant.Investigational
HexestrolThe serum concentration of Hexestrol can be decreased when it is combined with Aprepitant.Withdrawn
HexobarbitalThe serum concentration of Hexobarbital can be increased when it is combined with Aprepitant.Approved
Histamine PhosphateThe serum concentration of Histamine Phosphate can be increased when it is combined with Aprepitant.Approved
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Aprepitant.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Aprepitant.Approved, Vet Approved
HydromorphoneThe serum concentration of Hydromorphone can be increased when it is combined with Aprepitant.Approved, Illicit
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Aprepitant.Approved
IbrutinibThe serum concentration of Ibrutinib can be increased when it is combined with Aprepitant.Approved
IbuprofenThe metabolism of Ibuprofen can be increased when combined with Aprepitant.Approved
IdarubicinThe metabolism of Idarubicin can be increased when combined with Aprepitant.Approved
IdelalisibThe serum concentration of Aprepitant can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of Ifosfamide can be increased when it is combined with Aprepitant.Approved
IloperidoneThe serum concentration of Iloperidone can be increased when it is combined with Aprepitant.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Aprepitant.Approved
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Aprepitant.Approved
ImiquimodThe serum concentration of Imiquimod can be increased when it is combined with Aprepitant.Approved, Investigational
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Aprepitant.Approved
IndapamideThe serum concentration of Indapamide can be increased when it is combined with Aprepitant.Approved
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Aprepitant.Approved
indisulamThe metabolism of indisulam can be increased when combined with Aprepitant.Investigational
IndomethacinThe metabolism of Indomethacin can be increased when combined with Aprepitant.Approved, Investigational
Ipratropium bromideThe serum concentration of Ipratropium bromide can be increased when it is combined with Aprepitant.Approved
IrbesartanThe metabolism of Irbesartan can be increased when combined with Aprepitant.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Aprepitant.Approved, Investigational
IsavuconazoniumThe serum concentration of Isavuconazonium can be increased when it is combined with Aprepitant.Approved, Investigational
IsoniazidThe metabolism of Aprepitant can be decreased when combined with Isoniazid.Approved
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be increased when it is combined with Aprepitant.Approved
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be increased when it is combined with Aprepitant.Approved
IsradipineThe serum concentration of Isradipine can be increased when it is combined with Aprepitant.Approved
IstaroximeThe serum concentration of Istaroxime can be increased when it is combined with Aprepitant.Investigational
ItraconazoleThe serum concentration of Itraconazole can be increased when it is combined with Aprepitant.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be increased when it is combined with Aprepitant.Approved
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Aprepitant.Approved
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Aprepitant.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Aprepitant.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be increased when it is combined with Aprepitant.Approved
KetamineThe serum concentration of Ketamine can be increased when it is combined with Aprepitant.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Aprepitant.Approved
KetobemidoneThe serum concentration of Ketobemidone can be increased when it is combined with Aprepitant.Approved
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Aprepitant.Approved, Investigational
KetoprofenThe metabolism of Ketoprofen can be increased when combined with Aprepitant.Approved, Vet Approved
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Aprepitant.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Aprepitant.Approved, Investigational
LaquinimodThe serum concentration of Laquinimod can be increased when it is combined with Aprepitant.Investigational
LeflunomideThe metabolism of Leflunomide can be increased when combined with Aprepitant.Approved, Investigational
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Aprepitant.Approved
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Aprepitant.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be increased when combined with Aprepitant.Approved
LetrozoleThe serum concentration of Letrozole can be increased when it is combined with Aprepitant.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Aprepitant.Approved
LevocetirizineThe serum concentration of Levocetirizine can be increased when it is combined with Aprepitant.Approved
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be increased when it is combined with Aprepitant.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Aprepitant.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Aprepitant.Approved, Investigational
LevothyroxineThe serum concentration of Levothyroxine can be increased when it is combined with Aprepitant.Approved
LicofeloneThe metabolism of Licofelone can be increased when combined with Aprepitant.Investigational
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Aprepitant.Approved, Vet Approved
LisurideThe serum concentration of Lisuride can be increased when it is combined with Aprepitant.Approved
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Aprepitant.Approved
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Aprepitant.Approved
LopinavirThe serum concentration of Lopinavir can be increased when it is combined with Aprepitant.Approved
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Aprepitant.Approved
LorcaserinThe serum concentration of Lorcaserin can be increased when it is combined with Aprepitant.Approved
LornoxicamThe metabolism of Lornoxicam can be increased when combined with Aprepitant.Approved
LosartanThe serum concentration of Losartan can be increased when it is combined with Aprepitant.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Aprepitant.Approved, Investigational
LuliconazoleThe serum concentration of Aprepitant can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Aprepitant can be decreased when it is combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Aprepitant.Approved
LumiracoxibThe metabolism of Lumiracoxib can be increased when combined with Aprepitant.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Aprepitant.Approved
LynestrenolThe serum concentration of Lynestrenol can be decreased when it is combined with Aprepitant.Investigational
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Aprepitant.Approved
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Aprepitant.Approved, Investigational
ME-609The serum concentration of ME-609 can be increased when it is combined with Aprepitant.Investigational
MebendazoleThe serum concentration of Mebendazole can be increased when it is combined with Aprepitant.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Aprepitant.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be increased when it is combined with Aprepitant.Approved
Mefenamic acidThe metabolism of Mefenamic acid can be increased when combined with Aprepitant.Approved
MefloquineThe serum concentration of Mefloquine can be increased when it is combined with Aprepitant.Approved
MelatoninThe metabolism of Melatonin can be increased when combined with Aprepitant.Approved, Nutraceutical, Vet Approved
MelengestrolThe serum concentration of Melengestrol can be increased when it is combined with Aprepitant.Vet Approved
MeloxicamThe serum concentration of Meloxicam can be increased when it is combined with Aprepitant.Approved, Vet Approved
MephenytoinThe metabolism of Mephenytoin can be increased when combined with Aprepitant.Investigational, Withdrawn
MestranolThe serum concentration of Mestranol can be decreased when it is combined with Aprepitant.Approved
MethadoneThe serum concentration of Methadone can be increased when it is combined with Aprepitant.Approved
MethallenestrilThe serum concentration of Methallenestril can be decreased when it is combined with Aprepitant.Experimental
MethaqualoneThe serum concentration of Methaqualone can be increased when it is combined with Aprepitant.Illicit, Withdrawn
MethoxsalenThe serum concentration of Methoxsalen can be increased when it is combined with Aprepitant.Approved
MethoxyfluraneThe serum concentration of Methoxyflurane can be increased when it is combined with Aprepitant.Approved, Vet Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Aprepitant.Approved, Vet Approved
MethyltestosteroneThe serum concentration of Methyltestosterone can be increased when it is combined with Aprepitant.Approved
MetronidazoleThe serum concentration of Metronidazole can be increased when it is combined with Aprepitant.Approved
MexiletineThe serum concentration of Mexiletine can be increased when it is combined with Aprepitant.Approved
MianserinThe serum concentration of Mianserin can be increased when it is combined with Aprepitant.Approved
MibefradilThe serum concentration of Mibefradil can be increased when it is combined with Aprepitant.Withdrawn
MiconazoleThe serum concentration of Miconazole can be increased when it is combined with Aprepitant.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Aprepitant.Approved, Illicit
MifepristoneThe serum concentration of Aprepitant can be increased when it is combined with Mifepristone.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Aprepitant.Approved
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Aprepitant.Approved
MitotaneThe serum concentration of Aprepitant can be decreased when it is combined with Mitotane.Approved
MoclobemideThe metabolism of Moclobemide can be increased when combined with Aprepitant.Approved
ModafinilThe serum concentration of Modafinil can be increased when it is combined with Aprepitant.Approved, Investigational
MometasoneThe serum concentration of Mometasone can be increased when it is combined with Aprepitant.Approved, Vet Approved
MontelukastThe serum concentration of Montelukast can be increased when it is combined with Aprepitant.Approved
MorphineThe serum concentration of Morphine can be increased when it is combined with Aprepitant.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Aprepitant.Approved, Investigational
NafcillinThe serum concentration of Aprepitant can be decreased when it is combined with Nafcillin.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Aprepitant.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Aprepitant.Approved, Vet Approved
NaproxenThe metabolism of Naproxen can be increased when combined with Aprepitant.Approved, Vet Approved
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Aprepitant.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be increased when it is combined with Aprepitant.Investigational
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Aprepitant.Approved, Withdrawn
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Aprepitant.Approved
NetupitantThe serum concentration of Aprepitant can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of Nevirapine can be increased when it is combined with Aprepitant.Approved
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Aprepitant.Approved
NiclosamideThe metabolism of Niclosamide can be increased when combined with Aprepitant.Approved, Vet Approved
NicotineThe serum concentration of Nicotine can be increased when it is combined with Aprepitant.Approved
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Aprepitant.Approved
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Aprepitant.Approved, Investigational
NilvadipineThe serum concentration of Nilvadipine can be increased when it is combined with Aprepitant.Approved
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Aprepitant.Approved
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Aprepitant.Approved
NitrazepamThe serum concentration of Nitrazepam can be increased when it is combined with Aprepitant.Approved
NitrendipineThe serum concentration of Nitrendipine can be increased when it is combined with Aprepitant.Approved
NorelgestrominThe serum concentration of Norelgestromin can be decreased when it is combined with Aprepitant.Approved
NorethisteroneThe serum concentration of Norethisterone can be increased when it is combined with Aprepitant.Approved
NorgestimateThe serum concentration of Norgestimate can be decreased when it is combined with Aprepitant.Approved
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Aprepitant.Approved
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Aprepitant.Approved
OlaparibThe serum concentration of Olaparib can be increased when it is combined with Aprepitant.Approved
Oleoyl estroneThe serum concentration of Oleoyl estrone can be increased when it is combined with Aprepitant.Investigational
OlodaterolThe metabolism of Olodaterol can be increased when combined with Aprepitant.Approved
OlopatadineThe serum concentration of Olopatadine can be increased when it is combined with Aprepitant.Approved
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Aprepitant.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Aprepitant.Approved
OrphenadrineThe serum concentration of Orphenadrine can be increased when it is combined with Aprepitant.Approved
OsimertinibThe serum concentration of Aprepitant can be increased when it is combined with Osimertinib.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Aprepitant.Approved
OxaprozinThe metabolism of Oxaprozin can be increased when combined with Aprepitant.Approved
OxazepamThe serum concentration of Oxazepam can be increased when it is combined with Aprepitant.Approved
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Aprepitant.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Aprepitant is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe serum concentration of Oxymorphone can be increased when it is combined with Aprepitant.Approved, Investigational, Vet Approved
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Aprepitant.Approved, Vet Approved
PalbociclibThe serum concentration of Aprepitant can be increased when it is combined with Palbociclib.Approved
PalonosetronThe serum concentration of Palonosetron can be increased when it is combined with Aprepitant.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be increased when it is combined with Aprepitant.Approved, Investigational
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Aprepitant.Approved
ParamethadioneThe serum concentration of Paramethadione can be increased when it is combined with Aprepitant.Approved
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Aprepitant.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Aprepitant.Approved
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Aprepitant.Approved, Investigational
ParitaprevirThe serum concentration of Paritaprevir can be increased when it is combined with Aprepitant.Approved
ParoxetineThe serum concentration of Aprepitant can be decreased when it is combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Aprepitant.Approved
Peginterferon alfa-2bThe serum concentration of Aprepitant can be increased when it is combined with Peginterferon alfa-2b.Approved
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Aprepitant.Approved
PentobarbitalThe metabolism of Aprepitant can be increased when combined with Pentobarbital.Approved, Vet Approved
PerampanelThe serum concentration of Perampanel can be increased when it is combined with Aprepitant.Approved
PergolideThe serum concentration of Pergolide can be increased when it is combined with Aprepitant.Approved, Vet Approved, Withdrawn
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Aprepitant.Approved
PermethrinThe serum concentration of Permethrin can be increased when it is combined with Aprepitant.Approved, Investigational
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Aprepitant.Approved
PethidineThe serum concentration of Pethidine can be increased when it is combined with Aprepitant.Approved
PhenacetinThe serum concentration of Phenacetin can be increased when it is combined with Aprepitant.Withdrawn
PhenobarbitalThe metabolism of Aprepitant can be increased when combined with Phenobarbital.Approved
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be increased when it is combined with Aprepitant.Approved
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Aprepitant.Approved
PhenylbutazoneThe metabolism of Phenylbutazone can be increased when combined with Aprepitant.Approved, Vet Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Aprepitant.Approved, Vet Approved
PilocarpineThe serum concentration of Pilocarpine can be increased when it is combined with Aprepitant.Approved
PimecrolimusThe metabolism of Pimecrolimus can be decreased when combined with Aprepitant.Approved, Investigational
PimozideThe serum concentration of Pimozide can be increased when it is combined with Aprepitant.Approved
PinacidilThe serum concentration of Pinacidil can be increased when it is combined with Aprepitant.Withdrawn
PioglitazoneThe serum concentration of Pioglitazone can be increased when it is combined with Aprepitant.Approved, Investigational
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Aprepitant.Approved
PiroxicamThe metabolism of Piroxicam can be increased when combined with Aprepitant.Approved, Investigational
PitavastatinThe metabolism of Pitavastatin can be increased when combined with Aprepitant.Approved
PodofiloxThe serum concentration of Podofilox can be increased when it is combined with Aprepitant.Approved
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Aprepitant.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Aprepitant.Approved
PosaconazoleThe serum concentration of Posaconazole can be increased when it is combined with Aprepitant.Approved, Investigational, Vet Approved
PrasteroneThe serum concentration of Prasterone can be increased when it is combined with Aprepitant.Approved, Nutraceutical
PrasugrelThe serum concentration of Prasugrel can be increased when it is combined with Aprepitant.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Aprepitant.Approved
PrazepamThe serum concentration of Prazepam can be increased when it is combined with Aprepitant.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Aprepitant.Approved, Vet Approved
PrednicarbateThe serum concentration of Prednicarbate can be increased when it is combined with Aprepitant.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Aprepitant.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Aprepitant.Approved, Vet Approved
PregnenoloneThe serum concentration of Pregnenolone can be increased when it is combined with Aprepitant.Experimental
PrimaquineThe serum concentration of Primaquine can be increased when it is combined with Aprepitant.Approved
PrimidoneThe metabolism of Aprepitant can be increased when combined with Primidone.Approved, Vet Approved
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Aprepitant.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Aprepitant.Approved, Vet Approved
ProguanilThe serum concentration of Proguanil can be increased when it is combined with Aprepitant.Approved
PromazineThe serum concentration of Promazine can be increased when it is combined with Aprepitant.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Aprepitant.Approved
PropofolThe serum concentration of Propofol can be increased when it is combined with Aprepitant.Approved, Investigational, Vet Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Aprepitant.Approved, Investigational
PyrazinamideThe serum concentration of Pyrazinamide can be increased when it is combined with Aprepitant.Approved
QuazepamThe serum concentration of Quazepam can be increased when it is combined with Aprepitant.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Aprepitant.Approved
QuinacrineThe serum concentration of Quinacrine can be increased when it is combined with Aprepitant.Approved
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Aprepitant.Approved
QuinineThe serum concentration of Quinine can be increased when it is combined with Aprepitant.Approved
RabeprazoleThe serum concentration of Rabeprazole can be increased when it is combined with Aprepitant.Approved, Investigational
RaloxifeneThe serum concentration of Raloxifene can be increased when it is combined with Aprepitant.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Aprepitant.Approved, Investigational
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Aprepitant.Approved, Investigational
ReboxetineThe serum concentration of Reboxetine can be increased when it is combined with Aprepitant.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Aprepitant.Approved
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Aprepitant.Approved, Investigational
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Aprepitant.Approved
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Aprepitant.Approved
RifampicinThe serum concentration of Aprepitant can be decreased when it is combined with Rifampicin.Approved
RifapentineThe metabolism of Aprepitant can be increased when combined with Rifapentine.Approved
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Aprepitant.Approved
RimexoloneThe serum concentration of Rimexolone can be increased when it is combined with Aprepitant.Approved
RimonabantThe serum concentration of Rimonabant can be increased when it is combined with Aprepitant.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Aprepitant.Approved
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Aprepitant.Approved, Investigational
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Aprepitant.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Aprepitant.Approved
RofecoxibThe serum concentration of Rofecoxib can be increased when it is combined with Aprepitant.Investigational, Withdrawn
RolapitantThe serum concentration of Rolapitant can be increased when it is combined with Aprepitant.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Aprepitant.Approved, Investigational
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Aprepitant.Approved, Investigational
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Aprepitant.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be increased when combined with Aprepitant.Approved, Investigational
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Aprepitant.Approved
RotigotineThe serum concentration of Rotigotine can be increased when it is combined with Aprepitant.Approved
RoxithromycinThe serum concentration of Roxithromycin can be increased when it is combined with Aprepitant.Approved, Withdrawn
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Aprepitant.Approved
Salicylic acidThe metabolism of Salicylic acid can be increased when combined with Aprepitant.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Aprepitant.Approved
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Aprepitant.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Aprepitant.Approved
SelegilineThe serum concentration of Selegiline can be increased when it is combined with Aprepitant.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Aprepitant.Approved
SeratrodastThe serum concentration of Seratrodast can be increased when it is combined with Aprepitant.Approved, Investigational
SertindoleThe serum concentration of Sertindole can be increased when it is combined with Aprepitant.Approved, Withdrawn
SertralineThe serum concentration of Sertraline can be increased when it is combined with Aprepitant.Approved
SevofluraneThe serum concentration of Sevoflurane can be increased when it is combined with Aprepitant.Approved, Vet Approved
SibutramineThe serum concentration of Sibutramine can be increased when it is combined with Aprepitant.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Aprepitant.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Aprepitant.Approved
SiltuximabThe serum concentration of Aprepitant can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be increased when it is combined with Aprepitant.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Aprepitant.Approved
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Aprepitant.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Aprepitant.Approved, Investigational
SitaxentanThe metabolism of Sitaxentan can be increased when combined with Aprepitant.Approved, Investigational, Withdrawn
SolifenacinThe serum concentration of Solifenacin can be increased when it is combined with Aprepitant.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Aprepitant.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Aprepitant.Approved, Investigational
SpiramycinThe serum concentration of Spiramycin can be increased when it is combined with Aprepitant.Approved
St. John's WortThe serum concentration of Aprepitant can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Aprepitant can be increased when it is combined with Stiripentol.Approved
SufentanilThe serum concentration of Sufentanil can be increased when it is combined with Aprepitant.Approved, Investigational
SulfadiazineThe serum concentration of Sulfadiazine can be increased when it is combined with Aprepitant.Approved, Vet Approved
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be increased when it is combined with Aprepitant.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be increased when combined with Aprepitant.Approved
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be increased when it is combined with Aprepitant.Approved
SulfisoxazoleThe metabolism of Sulfisoxazole can be increased when combined with Aprepitant.Approved, Vet Approved
SunitinibThe serum concentration of Sunitinib can be increased when it is combined with Aprepitant.Approved, Investigational
SuprofenThe metabolism of Suprofen can be increased when combined with Aprepitant.Approved, Withdrawn
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Aprepitant.Approved
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Aprepitant.Approved
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be increased when it is combined with Aprepitant.Approved
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Aprepitant.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Aprepitant.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Aprepitant.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Aprepitant.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be increased when combined with Aprepitant.Approved
TasosartanThe serum concentration of Tasosartan can be increased when it is combined with Aprepitant.Approved
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be increased when it is combined with Aprepitant.Experimental
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Aprepitant.Approved
TelithromycinThe serum concentration of Telithromycin can be increased when it is combined with Aprepitant.Approved
TemazepamThe serum concentration of Temazepam can be increased when it is combined with Aprepitant.Approved
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Aprepitant.Approved
TeniposideThe serum concentration of Teniposide can be increased when it is combined with Aprepitant.Approved
TenofovirThe metabolism of Aprepitant can be decreased when combined with Tenofovir.Approved, Investigational
TenoxicamThe metabolism of Tenoxicam can be increased when combined with Aprepitant.Approved
TerbinafineThe serum concentration of Terbinafine can be increased when it is combined with Aprepitant.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Aprepitant.Withdrawn
TeriflunomideThe serum concentration of Aprepitant can be decreased when it is combined with Teriflunomide.Approved
TesmilifeneThe serum concentration of Tesmilifene can be increased when it is combined with Aprepitant.Investigational
TestosteroneThe serum concentration of Testosterone can be increased when it is combined with Aprepitant.Approved, Investigational
TetracyclineThe serum concentration of Tetracycline can be increased when it is combined with Aprepitant.Approved, Vet Approved
ThalidomideThe metabolism of Thalidomide can be increased when combined with Aprepitant.Approved, Investigational, Withdrawn
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Aprepitant.Approved
ThiamylalThe metabolism of Thiamylal can be increased when combined with Aprepitant.Approved, Vet Approved
ThiotepaThe serum concentration of Thiotepa can be increased when it is combined with Aprepitant.Approved
TiagabineThe serum concentration of Tiagabine can be increased when it is combined with Aprepitant.Approved
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Aprepitant.Approved
TiclopidineThe serum concentration of Ticlopidine can be increased when it is combined with Aprepitant.Approved
TinidazoleThe serum concentration of Tinidazole can be increased when it is combined with Aprepitant.Approved, Investigational
TiotropiumThe serum concentration of Tiotropium can be increased when it is combined with Aprepitant.Approved
TipranavirThe serum concentration of Tipranavir can be increased when it is combined with Aprepitant.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be increased when it is combined with Aprepitant.Approved
TocilizumabThe serum concentration of Aprepitant can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Aprepitant.Approved, Investigational
TolbutamideThe serum concentration of Tolbutamide can be decreased when it is combined with Aprepitant.Approved
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Aprepitant.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Aprepitant.Approved
TopiramateThe metabolism of Aprepitant can be decreased when combined with Topiramate.Approved
TorasemideThe metabolism of Torasemide can be increased when combined with Aprepitant.Approved
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Aprepitant.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be increased when it is combined with Aprepitant.Approved, Investigational
TramadolThe serum concentration of Tramadol can be increased when it is combined with Aprepitant.Approved, Investigational
TranylcypromineThe metabolism of Aprepitant can be decreased when combined with Tranylcypromine.Approved
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Aprepitant.Approved
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Aprepitant.Approved, Investigational
TreprostinilThe metabolism of Treprostinil can be increased when combined with Aprepitant.Approved, Investigational
TretinoinThe serum concentration of Tretinoin can be increased when it is combined with Aprepitant.Approved, Investigational, Nutraceutical
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Aprepitant.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Aprepitant.Approved
TrimethadioneThe serum concentration of Trimethadione can be increased when it is combined with Aprepitant.Approved
TrimethoprimThe serum concentration of Trimethoprim can be increased when it is combined with Aprepitant.Approved, Vet Approved
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Aprepitant.Approved
TroglitazoneThe serum concentration of Troglitazone can be increased when it is combined with Aprepitant.Withdrawn
TroleandomycinThe serum concentration of Troleandomycin can be increased when it is combined with Aprepitant.Approved
UdenafilThe serum concentration of Udenafil can be increased when it is combined with Aprepitant.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Aprepitant.Approved
ValdecoxibThe serum concentration of Valdecoxib can be increased when it is combined with Aprepitant.Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be increased when combined with Aprepitant.Approved, Investigational
ValsartanThe metabolism of Valsartan can be increased when combined with Aprepitant.Approved, Investigational
VandetanibThe serum concentration of Vandetanib can be increased when it is combined with Aprepitant.Approved
VanoxerineThe serum concentration of Vanoxerine can be increased when it is combined with Aprepitant.Investigational
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Aprepitant.Approved
VemurafenibThe serum concentration of Aprepitant can be increased when it is combined with Vemurafenib.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Aprepitant.Approved
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Aprepitant.Approved
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Aprepitant.Approved
VicrivirocThe serum concentration of Vicriviroc can be increased when it is combined with Aprepitant.Investigational
VilanterolThe serum concentration of Vilanterol can be increased when it is combined with Aprepitant.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Aprepitant.Approved
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Aprepitant.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Aprepitant.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Aprepitant.Approved
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Aprepitant.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Aprepitant.Approved
VoriconazoleThe serum concentration of Voriconazole can be increased when it is combined with Aprepitant.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Aprepitant.Approved
WarfarinThe serum concentration of Warfarin can be decreased when it is combined with Aprepitant.Approved
XimelagatranThe metabolism of Ximelagatran can be increased when combined with Aprepitant.Approved, Investigational, Withdrawn
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Aprepitant.Approved, Vet Approved
ZafirlukastThe serum concentration of Zafirlukast can be increased when it is combined with Aprepitant.Approved, Investigational
ZalcitabineThe serum concentration of Zalcitabine can be increased when it is combined with Aprepitant.Approved
ZaleplonThe serum concentration of Zaleplon can be increased when it is combined with Aprepitant.Approved, Illicit, Investigational
ZaltoprofenThe metabolism of Zaltoprofen can be increased when combined with Aprepitant.Approved
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Aprepitant.Approved
ZileutonThe serum concentration of Zileuton can be increased when it is combined with Aprepitant.Approved, Investigational, Withdrawn
ZiprasidoneThe serum concentration of Ziprasidone can be increased when it is combined with Aprepitant.Approved
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Aprepitant.Approved
ZomepiracThe serum concentration of Zomepirac can be increased when it is combined with Aprepitant.Withdrawn
ZonisamideThe serum concentration of Zonisamide can be increased when it is combined with Aprepitant.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Aprepitant.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Aprepitant.Approved, Investigational
Food Interactions
  • Take without regard to meals.
References
Synthesis Reference

Mangesh Shivram Sawant, Girish Dixit, Nitin Sharad Chandra Pradhan, Mubeen Ahmad Khan, Sukumar Sinha, “Amorphous and Crystalline Forms of Aprepitant and Processes for the Preparation Thereof.” U.S. Patent US20090192161, issued July 30, 2009.

US20090192161
General ReferencesNot Available
External Links
ATC CodesA04AD12
AHFS Codes
  • 56:22.92
PDB EntriesNot Available
FDA labelDownload (293 KB)
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9952
Blood Brain Barrier+0.5588
Caco-2 permeable-0.6237
P-glycoprotein substrateSubstrate0.8106
P-glycoprotein inhibitor IInhibitor0.5243
P-glycoprotein inhibitor IINon-inhibitor0.9564
Renal organic cation transporterNon-inhibitor0.7444
CYP450 2C9 substrateNon-substrate0.788
CYP450 2D6 substrateNon-substrate0.9115
CYP450 3A4 substrateSubstrate0.6461
CYP450 1A2 substrateNon-inhibitor0.6012
CYP450 2C9 inhibitorNon-inhibitor0.535
CYP450 2D6 inhibitorNon-inhibitor0.84
CYP450 2C19 inhibitorNon-inhibitor0.5862
CYP450 3A4 inhibitorInhibitor0.5
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.8396
Ames testNon AMES toxic0.5758
CarcinogenicityNon-carcinogens0.8152
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.6055 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.6598
hERG inhibition (predictor II)Inhibitor0.8163
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Merck and co inc
Packagers
Dosage forms
FormRouteStrength
CapsuleOral125 mg
CapsuleOral125 mg/1
CapsuleOral165 mg
CapsuleOral40 mg/1
CapsuleOral40 mg
CapsuleOral80 mg/1
CapsuleOral80 mg
Kit
Powder, for suspensionOral125 mg
Powder, for suspensionOral125 mg/1
Capsule; kitOral
Prices
Unit descriptionCostUnit
Emend 6 125 mg capsule Box1046.01USD box
Emend 6 80 mg capsule Box678.62USD box
Emend 5 80 mg capsule Box553.13USD box
Emend 3 80 & 125 mg capsule Disp Pack415.76USD disp
Emend 115 mg Solution 1 Vial = 10ml242.13USD vial
Emend 115 mg vial232.82USD vial
Emend 2 80 mg capsule Disp Pack226.21USD disp
Emend 125 mg capsule161.34USD capsule
Emend 80 mg capsule108.76USD capsule
Emend 40 mg capsule Box58.17USD box
Emend 40 mg capsule55.89USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2469315 No2008-12-022022-12-19Canada
US5145684 No1994-01-252011-01-25Us
US6096742 No1998-07-012018-07-01Us
US8258132 No2007-09-262027-09-26Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilityPractically insolubleNot Available
logP4.5Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0194 mg/mLALOGPS
logP2.44ALOGPS
logP5.22ChemAxon
logS-4.4ALOGPS
pKa (Strongest Acidic)9.65ChemAxon
pKa (Strongest Basic)3.51ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area75.19 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity116.93 m3·mol-1ChemAxon
Polarizability45.56 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylmorpholines. These are aromatic compounds containing a morpholine ring and a benzene ring linked to each other through a CC or a CN bond.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassOxazinanes
Sub ClassMorpholines
Direct ParentPhenylmorpholines
Alternative Parents
Substituents
  • Phenylmorpholine
  • Aralkylamine
  • Halobenzene
  • Fluorobenzene
  • Benzenoid
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl fluoride
  • Heteroaromatic compound
  • 1,2,4-triazole
  • Azole
  • Tertiary aliphatic amine
  • Tertiary amine
  • Oxacycle
  • Azacycle
  • Acetal
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Organofluoride
  • Organohalogen compound
  • Amine
  • Alkyl halide
  • Alkyl fluoride
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Tachykinin receptor activity
Specific Function:
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
Gene Name:
TACR1
Uniprot ID:
P25103
Molecular Weight:
46250.5 Da
References
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Brands KM, Payack JF, Rosen JD, Nelson TD, Candelario A, Huffman MA, Zhao MM, Li J, Craig B, Song ZJ, Tschaen DM, Hansen K, Devine PN, Pye PJ, Rossen K, Dormer PG, Reamer RA, Welch CJ, Mathre DJ, Tsou NN, McNamara JM, Reider PJ: Efficient synthesis of NK(1) receptor antagonist aprepitant using a crystallization-induced diastereoselective transformation. J Am Chem Soc. 2003 Feb 26;125(8):2129-35. [PubMed:12590540 ]
  3. Rodgers J, Bradley B, Kennedy PG: Combination chemotherapy with a substance P receptor antagonist (aprepitant) and melarsoprol in a mouse model of human African trypanosomiasis. Parasitol Int. 2007 Dec;56(4):321-4. Epub 2007 Jun 29. [PubMed:17643344 ]
  4. Poli-Bigelli S, Rodrigues-Pereira J, Carides AD, Julie Ma G, Eldridge K, Hipple A, Evans JK, Horgan KJ, Lawson F: Addition of the neurokinin 1 receptor antagonist aprepitant to standard antiemetic therapy improves control of chemotherapy-induced nausea and vomiting. Results from a randomized, double-blind, placebo-controlled trial in Latin America. Cancer. 2003 Jun 15;97(12):3090-8. [PubMed:12784346 ]
  5. Zhao MM, McNamara JM, Ho GJ, Emerson KM, Song ZJ, Tschaen DM, Brands KM, Dolling UH, Grabowski EJ, Reider PJ, Cottrell IF, Ashwood MS, Bishop BC: Practical asymmetric synthesis of aprepitant, a potent human NK-1 receptor antagonist, via a stereoselective Lewis acid-catalyzed trans acetalization reaction. J Org Chem. 2002 Sep 20;67(19):6743-7. [PubMed:12227806 ]
  6. Bergstrom M, Hargreaves RJ, Burns HD, Goldberg MR, Sciberras D, Reines SA, Petty KJ, Ogren M, Antoni G, Langstrom B, Eskola O, Scheinin M, Solin O, Majumdar AK, Constanzer ML, Battisti WP, Bradstreet TE, Gargano C, Hietala J: Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant. Biol Psychiatry. 2004 May 15;55(10):1007-12. [PubMed:15121485 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Sanchez RI, Wang RW, Newton DJ, Bakhtiar R, Lu P, Chiu SH, Evans DC, Huskey SE: Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant. Drug Metab Dispos. 2004 Nov;32(11):1287-92. Epub 2004 Aug 10. [PubMed:15304427 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Sanchez RI, Wang RW, Newton DJ, Bakhtiar R, Lu P, Chiu SH, Evans DC, Huskey SE: Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant. Drug Metab Dispos. 2004 Nov;32(11):1287-92. Epub 2004 Aug 10. [PubMed:15304427 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Sanchez RI, Wang RW, Newton DJ, Bakhtiar R, Lu P, Chiu SH, Evans DC, Huskey SE: Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant. Drug Metab Dispos. 2004 Nov;32(11):1287-92. Epub 2004 Aug 10. [PubMed:15304427 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
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Drug created on June 13, 2005 07:24 / Updated on December 10, 2016 02:40