Name
Incretins
Accession Number
DBCAT001316
Description

Peptides which stimulate INSULIN release from the PANCREATIC BETA CELLS following oral nutrient ingestion, or postprandially.

Drugs
DrugDrug Description
SitagliptinAn oral dipeptidyl peptidase-4 (DPP-4) inhibitor used for the management of type 2 diabetes mellitus.
ExenatideA GLP-1 agonist used in the management of type 2 diabetes mellitus.
AlogliptinA dipeptidyl peptidase-4 (DPP-4) inhibitor used to treat hyperglycemia in patients with type 2 diabetes mellitus.
SaxagliptinAn DPP-4 inhibitor used for the management of type 2 diabetes mellitus.
LiraglutideA GLP-1 analog used in the management of type 2 diabetes mellitus and prevention of cardiovascular complications associated with diabetes.
LinagliptinA dipeptidyl peptidase-4 (DPP-4) inhibitor used to manage hyperglycemia in patients with type 2 diabetes mellitus.
AlbiglutideA GLP-1 agonist used to manage type 2 diabetes mellitus.
Gastric inhibitory polypeptideGastric inhibitory polypeptide is under investigation in clinical trial NCT03081676 (The Effect of GIP and GLP-1 on Insulin and Glucagon Secretion in Patients With HNF1A-diabetes Treated With or Without Sulphonylurea).
TirzepatideTirzepatide is under investigation in clinical trial NCT03311724 (A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes).
Drugs & Drug Targets
DrugTargetType
SitagliptinDipeptidyl peptidase 4target
SitagliptinCytochrome P450 3A4enzyme
SitagliptinCytochrome P450 2C8enzyme
SitagliptinP-glycoprotein 1transporter
SitagliptinSolute carrier family 22 member 8transporter
ExenatideGlucagon-like peptide 1 receptortarget
ExenatideSerum albumincarrier
ExenatideDipeptidyl peptidase 4enzyme
AlogliptinDipeptidyl peptidase 4target
AlogliptinCytochrome P450 3A4enzyme
AlogliptinCytochrome P450 2D6enzyme
SaxagliptinDipeptidyl peptidase 4target
SaxagliptinCytochrome P450 3A4enzyme
SaxagliptinCytochrome P450 3A5enzyme
SaxagliptinMultidrug resistance-associated protein 1transporter
SaxagliptinSolute carrier organic anion transporter family member 4C1transporter
SaxagliptinSolute carrier family 22 member 8transporter
LiraglutideGlucagon-like peptide 1 receptortarget
LiraglutideDipeptidyl peptidase 4enzyme
LiraglutideNeprilysinenzyme
LiraglutideSerum albumincarrier
LinagliptinDipeptidyl peptidase 4target
LinagliptinCytochrome P450 3A4enzyme
LinagliptinP-glycoprotein 1transporter
LinagliptinSolute carrier family 22 member 1transporter
LinagliptinSolute carrier family 22 member 2transporter
LinagliptinSolute carrier family 22 member 3transporter
AlbiglutideGlucagon-like peptide 1 receptortarget