Tyrosine Kinase Inhibitors

DrugDrug NameDrug Indication
DB02058SU4984Not Available
DB02424GeldanamycinNot Available
DB02567PD173955Not Available
DB03758RadicicolNot Available
DB04868NilotinibFor the potential treatment of various leukemias, including chronic myeloid leukemia (CML).
DB05465TandutinibInvestigated for use/treatment in leukemia (myeloid).
DB08399PICEATANNOLNot Available
DB11904FlumatinibNot Available
DB01645GenisteinCurrently Genistein is being studied in clinical trials as a treatment for prostate cancer.
DB00619ImatinibFor the treatment of Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML), Ph+ acute lymphoblastic leukaemia, myelodysplastic/myeloproliferative diseases, aggressive systemic mastocytosis, hypereosinophilic syndrome and/or chronic eosinophilic leukemia (CEL), dermatofibrosarcoma protuberans, and malignant gastrointestinal stromal tumors (GIST).
DB01268SunitinibFor the treatment of advanced renal cell carcinoma as well as the treatment of gastrointestinal stromal tumor after disease progression on or intolerance to imatinib mesylate.
DB00317GefitinibFor the continued treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of either platinum-based or docetaxel chemotherapies.
DB00530ErlotinibFor the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of at least one prior chemotherapy regimen. Also for use, in combination with gemcitabine, as the first-line treatment of patients with locally advanced, unresectable or metastatic pancreatic cancer.
DB08881VemurafenibVemurafenib is approved since 2011 for the treatment of metastatic melanoma with a mutation on BRAF in the valine located in the exon 15 at codon 600, this mutation is denominated as V600E.[A31270] The V600E mutation, a substitution of glutamic acid for valine, accounts for 54% of the cases of cutaneous melanoma.[A31271] Vemurafenib approval was extended in 2017, for its use as a treatment of adult patients with Erdheim-Chester Disease whose cancer cells present BRAF V600 mutation.[L1013] Erdheim-Chester disease is an extremely rare histiocyte cell disorder that affects large bones, large vessels, central nervous system, as well as, skin and lungs. It is reported an association of Erdheim-Chester disease and V600E mutation.[A31272]
DB00398SorafenibSorafenib is indicated for the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinoma.
DB06589PazopanibTreatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
DB01259LapatinibIndicated in combination with capecitabine for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress the human epidermal receptor type 2 (HER2) protein and who have received prior therapy including an anthracycline, a taxane, and trastuzuma.
DB05575MotesanibInvestigated for use/treatment in solid tumors.
DB08875CabozantinibFor the treatment of metastatic medullary thyroid cancer and for the treatment of patients with advanced renal cell carcinoma (RCC) who have received prior anti-angiogenic therapy.
DB06626AxitinibUsed in kidney cell cancer and investigated for use/treatment in pancreatic and thyroid cancer.
DB01254DasatinibFor the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy. Also indicated for the treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia with resistance or intolerance to prior therapy.
DB11689SelumetinibNot Available
DB09053IbrutinibIbrutinib acquired an accelerated approval for the treatment of mantle cell lymphoma who have received at least one prior therapy.[FDA label] Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma that develops in the outer edge of a lymph node. MCL is usually diagnosed at late stages and it is easily spread into bone marrow, spleen, liver and gastrointestinal tract.[L1929] Ibrutinib is indicated for the treatment of chronic lymphocytic leukemia (CLL) who have at least one prior therapy.[FDA label] CLL is a type of cancer caused by an overproduction of lymphocytes by the bone marrow. Some of the symptoms include swollen lymph nodes and tiredness.[L1931] Ibrutinib is indicated for the treatment of chronic lymphocytic leukemia (CLL) with 17p deletion.[FDA label] CLL with 17p is a type of leukemia in which a deletion in 17p disrupts the tumor suppressor p53 by deleting one allele of the TP53 gene. The remaining allele is mainly inactivated and thus, this type of leukemia is unresponsive to p53-dependent treatments.[A32305] Ibrutinib is indicated for the treatment of patients with Waldenstrom's Macroglobulinemia (WM).[FDA label] WM, also called lymphoplasmacytic lymphoma, is a type of non-Hodgkin lymphoma in which the cancer cells make large amounts of macroglobulin. The macroglobulin is a monoclonal protein that corresponds to the type of IgM antibodies and the unrestricted formation of this protein causes typical symptoms such as excessive bleeding and effects in vision and nervous system.[L1934]
DB05294VandetanibVandetanib is currently approved as an alternative to local therapies for both unresectable and disseminated disease. Because Vandetanib can prolong the Q-T interval, it is contraindicated for use in patients with serious cardiac complications such as congenital long QT syndrome and uncompensated heart failure.
DB06616BosutinibTreatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) with resistance or intolerance to prior therapy in adult patients.
DB09079NintedanibNintedanib is indicated for the treatment of idiopathic pulmonary fibrosis (IPF).
DB12010FostamatinibFostamatinib is indicated for use in the treatment of chronic immune thrombocytopenia (ITP) in patients who have had insufficient response to previous therapy [FDA Label].
DB11703AcalabrutinibAcalabrutinib is currently indicated for the treatment of adult patients with Mantle Cell Lymphoma (MCL) who have received at least one prior therapy [FDA Label].
DB08901PonatinibPonatinib is indicated for the treatment of adult patients with chronic phase, accelerated phase, or blast phase chronic myeloid leukemia (CML) that is resistant or intolerant to prior tyrosine kinase inhibitor therapy or Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ALL) that is resistant or intolerant to prior tyrosine kinase inhibitor therapy.
DB08916AfatinibAfatinib is a kinase inhibitor indicated as monotherapy [L2937] for the first-line [FDA Label] treatment of (a) Epidermal Growth Factor Receptor (EGFR) TKI (tyrosine kinase inhibitor)-naive adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) whose tumours have non-resistant EGFR mutations as detected by an FDA-approved test [FDA Label], and (b) adult patients with locally advanced or metastatic NSCLC of squamous histology progressing on or after platinum-based chemotherapy [FDA Label, L2937]. Recently, as of January 2018, the US FDA approved a supplemental New Drug Application for Boehringer Ingelheim's Gilotrif (afatinib) for the first line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have non-resistant epidermal growth factor receptor (EGFR) mutations as detected by an FDA-approved test [L2939]. The new label includes data on three additional EGFR mutations: L861Q, G719X and S768I [L2939].
DB04849CediranibFor the treatment of liver cancer, advanced non-small cell lung cancer (NSCLC), advanced colorectal cancer (CRC) and other solid tumors.
DB05928DovitinibInvestigated for use/treatment in multiple myeloma and solid tumors.
DB09078LenvatinibLenvatinib is indicated for the treatment of patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer.
DB08877RuxolitinibTreatment of intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera (post-PV) myelofibrosis and post-essential thrombocythemia (post-ET) myelofibrosis. [Lexicomp] Myeolofibrosis is the proliferation of abnormal bone marrow stem cells which cause fibrosis (the excessive formation of connective tissue).
DB11697PacritinibNot Available
DB08865CrizotinibCrizotinib is used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) that is anaplastic-lymphoma kinase (ALK)-positive as detected by a FDA-approved test.
DB06469LestaurtinibInvestigated for use/treatment in pancreatic cancer, prostate cancer, and leukemia (myeloid).
DB11805SaracatinibNot Available
DB11363AlectinibAlectinib is a kinase inhibitor indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive, metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to crizotinib. This indication is approved under accelerated approval based on tumor response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials.
DB12267BrigatinibThe anaplastic lymphoma kinase positive, metastatic non-small cell lung cancer (ALK+ NSCLC), represents only 3-5% of the NSCLC cancer cases, but the ALK mutation, overexpression and presence in several oncogenic fusion proteins in solid and hematologic tumors have pointed out the importance as well as its potential as a cancer therapy target.[A31311] The ALK-related cases of NSCLC are associated with the presence of the fusion gene EML4-ALK which fused the ALK protein with the echinoderm microtubule-associated protein like-4 whose original function is the correct formation of microtubules.[A31313] The presence of the aberrant fusion protein results in abnormal signaling that provokes increased cell growth, proliferation and survival.[A31316] Crizotinib is indicated for the treatment of such cases but the presence of ALK kinase domain mutations confer resistance to the treatment. Thus, brigatinib is indicated for the treatment of patients with ALK+ NSCLC with intolerance to Crizotinib.[A31314]
DB09063CeritinibCeritinib is a kinase inhibitor indicated for the treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to crizotinib. This indication is approved under accelerated approval based on tumor response rate and duration of response. An improvement in survival or disease-related symptoms has not been established. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials.
DB06595MidostaurinInvestigated for use/treatment in adult patients with high-risk acute myeloid leukemia (AML) who are FLT3 mutation-positive, agressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematological neoplasm (SM-AHN), or mast cell leukemia (MCL).
DB11828NeratinibFor use as an extended adjuvant treatment in adult patients with early stage HER2-overexpressed/amplified breast cancer, to follow adjuvant trastuzumab-based therapy [FDA Label].
DB09330OsimertinibOsimertinib is indicated for the treatment of patients with metastatic epidermal growth factor receptor (EGFR) T790M mutation-positive non-small cell lung cancer (NSCLC), as detected by an FDA- approved test, who have progressed on or after EGFR-TKI therapy.
DB08896RegorafenibRegorafenib is indicated for the treatment of patients with metastatic colorectal cancer (CRC) who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if KRAS wild type, an anti-EGFR therapy. Regorafenib is also indicated for the treatment of patients with locally advanced, unresectable or metastatic gastrointestinal stromal tumor (GIST) who have been previously treated with imatinib mesylate and sunitinib malate.
DB05424CanertinibInvestigated for use/treatment in breast cancer and lung cancer.
DB11832CrenolanibNot Available
DB11986EntrectinibNot Available
DB12307ForetinibNot Available
DB06302GlesatinibInvestigated for use/treatment in cancer/tumors (unspecified).
DB11737IcotinibIcotinib hydrochloride is a novel epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitor, exhibits encouraging efficacy and tolerability in patients with advanced non-small-cell lung cancer (NSCLC) who failed previous chemotherapy.
DB12323RadotinibRadotinib is indicated for the treatment of different types of cancer, most notably Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) with resistance or intolerance of other Bcr-Abl tyrosine-kinase inhibitors, such as patients resistant or intolerant to imatinib.
DB12048SavolitinibNot Available
DB11973TesevatinibNot Available
DB04879VatalanibUsed in combination with first- and second-line chemotherapy for the treatment of metastatic colorectal cancer and non-small cell lung cancer (NSCLC).
DrugDrug NameTargetType
DB02058SU4984Fibroblast growth factor receptor 2target
DB02058SU4984Fibroblast growth factor receptor 1target
DB02424GeldanamycinHeat shock protein HSP 90-alphatarget
DB02424GeldanamycinHeat shock protein HSP 90-betatarget
DB02424GeldanamycinEndoplasmintarget
DB02567PD173955Tyrosine-protein kinase transforming protein Abltarget
DB03758RadicicolHeat shock protein HSP 90-betatarget
DB03758RadicicolEndoplasmintarget
DB03758RadicicolDihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialtarget
DB03758Radicicol[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrialtarget
DB03758RadicicolVirulence sensor histidine kinase PhoQtarget
DB04868NilotinibTyrosine-protein kinase ABL1target
DB04868NilotinibMast/stem cell growth factor receptor Kittarget
DB04868NilotinibCytochrome P450 2D6enzyme
DB04868NilotinibCytochrome P450 2C8enzyme
DB04868NilotinibCytochrome P450 2C9enzyme
DB04868NilotinibCytochrome P450 3A4enzyme
DB04868NilotinibMultidrug resistance protein 1transporter
DB04868NilotinibATP-binding cassette sub-family G member 2transporter
DB04868NilotinibUDP-glucuronosyltransferase 1-1transporter
DB04868NilotinibCytochrome P450 2B6enzyme
DB04868NilotinibSolute carrier organic anion transporter family member 1B1transporter
DB05465TandutinibReceptor-type tyrosine-protein kinase FLT3target
DB05465TandutinibPlatelet-derived growth factor Dtarget
DB08399PICEATANNOLATP synthase subunit alpha, mitochondrialtarget
DB08399PICEATANNOLATP synthase subunit beta, mitochondrialtarget
DB08399PICEATANNOLATP synthase subunit gamma, mitochondrialtarget
DB01645GenisteinEstrogen receptor betatarget
DB01645GenisteinDNA topoisomerase 2-alphatarget
DB01645GenisteinProtein-tyrosine kinase 2-betatarget
DB01645GenisteinMultidrug resistance protein 1transporter
DB01645GenisteinMultidrug resistance-associated protein 1transporter
DB01645GenisteinATP-binding cassette sub-family G member 2transporter
DB01645GenisteinCytochrome P450 1A2enzyme
DB01645GenisteinNuclear receptor coactivator 1target
DB01645GenisteinEstrogen receptor alphatarget
DB01645GenisteinNuclear receptor coactivator 2target
DB01645GenisteinTransthyretincarrier
DB01645GenisteinSteroid hormone receptor ERR2target
DB01645GenisteinSteroid hormone receptor ERR1target
DB01645GenisteinNuclear receptor subfamily 1 group I member 2target
DB01645GenisteinRAC-alpha serine/threonine-protein kinasetarget
DB01645GenisteinG-protein coupled estrogen receptor 1target
DB01645GenisteinCytochrome P450 1B1target
DB01645GenisteinSex hormone-binding globulintarget
DB01645GenisteinCytochrome P450 1A1enzyme
DB01645GenisteinSolute carrier organic anion transporter family member 1B1transporter
DB01645GenisteinSolute carrier organic anion transporter family member 2B1transporter
DB01645GenisteinCytochrome P450 2C8enzyme
DB01645GenisteinCytochrome P450 2C9enzyme
DB01645GenisteinCytochrome P450 3A1enzyme
DB01645GenisteinCytochrome P450 3A2enzyme
DB01645GenisteinCYP3Aenzyme
DB00619ImatinibPlatelet-derived growth factor receptor betatarget
DB00619ImatinibTyrosine-protein kinase ABL1target
DB00619ImatinibMast/stem cell growth factor receptor Kittarget
DB00619ImatinibRET proto-oncogenetarget
DB00619ImatinibHigh affinity nerve growth factor receptortarget
DB00619ImatinibMacrophage colony-stimulating factor 1 receptortarget
DB00619ImatinibPlatelet-derived growth factor receptor alphatarget
DB00619ImatinibEpithelial discoidin domain-containing receptor 1target
DB00619ImatinibCytochrome P450 3A4enzyme
DB00619ImatinibBCR/ABL fusion protein isoform X9target
DB00619ImatinibCytochrome P450 1A2enzyme
DB00619ImatinibCytochrome P450 2D6enzyme
DB00619ImatinibCytochrome P450 2C9enzyme
DB00619ImatinibCytochrome P450 2C19enzyme
DB00619ImatinibCytochrome P450 3A5enzyme
DB00619ImatinibCytochrome P450 3A7enzyme
DB00619ImatinibSolute carrier family 22 member 1transporter
DB00619ImatinibMultidrug resistance protein 1transporter
DB00619ImatinibSolute carrier family 22 member 2transporter
DB00619ImatinibATP-binding cassette sub-family G member 2transporter
DB00619ImatinibATP-binding cassette sub-family A member 3transporter
DB00619ImatinibProstaglandin G/H synthase 1enzyme
DB00619ImatinibSerum albumincarrier
DB00619ImatinibAlpha-1-acid glycoprotein 1carrier
DB00619ImatinibBile salt export pumptransporter
DB01268SunitinibPlatelet-derived growth factor receptor betatarget
DB01268SunitinibVascular endothelial growth factor receptor 1target
DB01268SunitinibVascular endothelial growth factor receptor 2target
DB01268SunitinibVascular endothelial growth factor receptor 3target
DB01268SunitinibMast/stem cell growth factor receptor Kittarget
DB01268SunitinibReceptor-type tyrosine-protein kinase FLT3target
DB01268SunitinibMacrophage colony-stimulating factor 1 receptortarget
DB01268SunitinibPlatelet-derived growth factor receptor alphatarget
DB01268SunitinibCytochrome P450 3A4enzyme
DB01268SunitinibCytochrome P450 3A5enzyme
DB01268SunitinibCytochrome P450 3A7enzyme
DB01268SunitinibMultidrug resistance-associated protein 4transporter
DB01268SunitinibMultidrug resistance protein 1transporter
DB01268SunitinibCanalicular multispecific organic anion transporter 1transporter
DB01268SunitinibATP-binding cassette sub-family G member 2transporter
DB01268SunitinibCYP3Aenzyme
DB00317GefitinibEpidermal growth factor receptortarget
DB00317GefitinibCytochrome P450 3A4enzyme
DB00317GefitinibCytochrome P450 2D6enzyme
DB00317GefitinibMultidrug resistance protein 1transporter
DB00317GefitinibATP-binding cassette sub-family G member 2transporter
DB00317GefitinibCytochrome P450 3A5enzyme
DB00317GefitinibCytochrome P450 1A1enzyme
DB00317GefitinibCytochrome P450 2C9enzyme
DB00317GefitinibCytochrome P450 2C19enzyme
DB00317GefitinibSerum albumincarrier
DB00317GefitinibAlpha-1-acid glycoprotein 1carrier
DB00317GefitinibCYP3Aenzyme
DB00530ErlotinibEpidermal growth factor receptortarget
DB00530ErlotinibCytochrome P450 3A4enzyme
DB00530ErlotinibATP-binding cassette sub-family G member 2transporter
DB00530ErlotinibMultidrug resistance protein 1transporter
DB00530ErlotinibNuclear receptor subfamily 1 group I member 2target
DB00530ErlotinibCytochrome P450 3A5enzyme
DB00530ErlotinibCytochrome P450 1A1enzyme
DB00530ErlotinibCytochrome P450 1A2enzyme
DB00530ErlotinibCytochrome P450 1B1enzyme
DB00530ErlotinibCytochrome P450 2D6enzyme
DB00530ErlotinibCytochrome P450 2C8enzyme
DB00530ErlotinibUDP-glucuronosyltransferase 1-1enzyme
DB00530ErlotinibSerum albumincarrier
DB00530ErlotinibAlpha-1-acid glycoprotein 1carrier
DB00530ErlotinibSolute carrier organic anion transporter family member 2B1transporter
DB00530ErlotinibCYP3Aenzyme
DB08881VemurafenibSerum albumincarrier
DB08881VemurafenibAlpha-1-acid glycoprotein 1carrier
DB08881VemurafenibCytochrome P450 1A2enzyme
DB08881VemurafenibCytochrome P450 2D6enzyme
DB08881VemurafenibCytochrome P450 3A4enzyme
DB08881VemurafenibSerine/threonine-protein kinase B-raftarget
DB08881VemurafenibMultidrug resistance-associated protein 1transporter
DB08881VemurafenibATP-binding cassette sub-family G member 2transporter
DB08881VemurafenibCytochrome P450 2C9enzyme
DB00398SorafenibSerine/threonine-protein kinase B-raftarget
DB00398SorafenibReceptor-type tyrosine-protein kinase FLT3target
DB00398SorafenibRAF proto-oncogene serine/threonine-protein kinasetarget
DB00398SorafenibVascular endothelial growth factor receptor 3target
DB00398SorafenibPlatelet-derived growth factor receptor betatarget
DB00398SorafenibMast/stem cell growth factor receptor Kittarget
DB00398SorafenibVascular endothelial growth factor receptor 2target
DB00398SorafenibCytochrome P450 3A4enzyme
DB00398SorafenibUDP-glucuronosyltransferase 1-9enzyme
DB00398SorafenibCytochrome P450 2B6enzyme
DB00398SorafenibCytochrome P450 2C8enzyme
DB00398SorafenibCytochrome P450 3A5enzyme
DB00398SorafenibCytochrome P450 3A7enzyme
DB00398SorafenibCytochrome P450 2C9enzyme
DB00398SorafenibMultidrug resistance-associated protein 4transporter
DB00398SorafenibMultidrug resistance protein 1transporter
DB00398SorafenibCanalicular multispecific organic anion transporter 1transporter
DB00398SorafenibATP-binding cassette sub-family G member 2transporter
DB00398SorafenibCytochrome P450 1A2enzyme
DB00398SorafenibCytochrome P450 2C19enzyme
DB00398SorafenibCytochrome P450 2D6enzyme
DB00398SorafenibUDP-glucuronosyltransferase 1-1enzyme
DB00398SorafenibRalA-binding protein 1transporter
DB00398SorafenibFibroblast growth factor receptor 1target
DB00398SorafenibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB00398SorafenibVascular endothelial growth factor receptor 1target
DB00398SorafenibSolute carrier organic anion transporter family member 1B1transporter
DB06589PazopanibVascular endothelial growth factor receptor 1target
DB06589PazopanibVascular endothelial growth factor receptor 2target
DB06589PazopanibVascular endothelial growth factor receptor 3target
DB06589PazopanibPlatelet-derived growth factor receptor alphatarget
DB06589PazopanibPlatelet-derived growth factor receptor betatarget
DB06589PazopanibMast/stem cell growth factor receptor Kittarget
DB06589PazopanibCytochrome P450 3A4enzyme
DB06589PazopanibCytochrome P450 2D6enzyme
DB06589PazopanibCytochrome P450 2C8enzyme
DB06589PazopanibCytochrome P450 1A2enzyme
DB06589PazopanibMultidrug resistance protein 1transporter
DB06589PazopanibATP-binding cassette sub-family G member 2transporter
DB06589PazopanibSolute carrier organic anion transporter family member 1B1transporter
DB06589PazopanibUDP-glucuronosyltransferase 1-1transporter
DB06589PazopanibFibroblast growth factor receptor 3target
DB06589PazopanibTyrosine-protein kinase ITK/TSKtarget
DB06589PazopanibFibroblast growth factor 1target
DB06589PazopanibSH2B adapter protein 3target
DB01259LapatinibEpidermal growth factor receptortarget
DB01259LapatinibReceptor tyrosine-protein kinase erbB-2target
DB01259LapatinibCytochrome P450 3A4enzyme
DB01259LapatinibCytochrome P450 2C8enzyme
DB01259LapatinibMultidrug resistance protein 1transporter
DB01259LapatinibAntigen peptide transporter 1transporter
DB01259LapatinibCytochrome P450 3A5enzyme
DB01259LapatinibCytochrome P450 2C19enzyme
DB08875CabozantinibCytochrome P450 3A4enzyme
DB08875CabozantinibCytochrome P450 2C9enzyme
DB08875CabozantinibHepatocyte growth factor receptortarget
DB08875CabozantinibVascular endothelial growth factor receptor 2target
DB08875CabozantinibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB08875CabozantinibCytochrome P450 2C8enzyme
DB06626AxitinibVascular endothelial growth factor receptor 1target
DB06626AxitinibVascular endothelial growth factor receptor 2target
DB06626AxitinibVascular endothelial growth factor receptor 3target
DB06626AxitinibCytochrome P450 3A4enzyme
DB06626AxitinibCytochrome P450 3A5enzyme
DB06626AxitinibCytochrome P450 1A2enzyme
DB06626AxitinibCytochrome P450 2C19enzyme
DB06626AxitinibUDP-glucuronosyltransferase 1-1enzyme
DB06626AxitinibMultidrug resistance protein 1transporter
DB06626AxitinibSolute carrier organic anion transporter family member 1B1transporter
DB01254DasatinibTyrosine-protein kinase ABL1target
DB01254DasatinibAbelson tyrosine-protein kinase 2target
DB01254DasatinibProto-oncogene tyrosine-protein kinase Srctarget
DB01254DasatinibTyrosine-protein kinase Fyntarget
DB01254DasatinibTyrosine-protein kinase Lcktarget
DB01254DasatinibTyrosine-protein kinase Yestarget
DB01254DasatinibMast/stem cell growth factor receptor Kittarget
DB01254DasatinibPlatelet-derived growth factor receptor betatarget
DB01254DasatinibEphrin type-A receptor 2target
DB01254DasatinibSignal transducer and activator of transcription 5Btarget
DB01254DasatinibCytochrome P450 3A4enzyme
DB01254DasatinibMultidrug resistance protein 1transporter
DB01254DasatinibATP-binding cassette sub-family G member 2transporter
DB01254DasatinibCytochrome P450 1A1enzyme
DB01254DasatinibCytochrome P450 1A2enzyme
DB01254DasatinibCytochrome P450 1B1enzyme
DB01254DasatinibCytochrome P450 3A5enzyme
DB01254DasatinibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB01254DasatinibTyrosine-protein kinase BTKtarget
DB01254DasatinibNuclear receptor subfamily 4 group A member 3target
DB01254DasatinibBreakpoint cluster region proteintarget
DB01254DasatinibTyrosine-protein kinase CSKtarget
DB01254DasatinibEphrin type-A receptor 5target
DB01254DasatinibEphrin type-B receptor 4target
DB01254DasatinibTyrosine-protein kinase Fgrtarget
DB01254DasatinibTyrosine-protein kinase FRKtarget
DB01254DasatinibHeat shock cognate 71 kDa proteintarget
DB01254DasatinibTyrosine-protein kinase Lyntarget
DB01254DasatinibMitogen-activated protein kinase kinase kinase MLTtarget
DB01254DasatinibMitogen-activated protein kinase 14target
DB01254DasatinibAmidophosphoribosyltransferasetarget
DB09053IbrutinibTyrosine-protein kinase BTKtarget
DB09053IbrutinibCytochrome P450 3A4enzyme
DB09053IbrutinibCytochrome P450 3A5enzyme
DB09053IbrutinibSerum albumincarrier
DB09053Ibrutinibalpha1-acid glycoproteincarrier
DB09053IbrutinibCytochrome P450 2D6enzyme
DB05294VandetanibVascular endothelial growth factor Atarget
DB05294VandetanibEpidermal growth factor receptortarget
DB05294VandetanibMultidrug resistance-associated protein 1transporter
DB05294VandetanibATP-binding cassette sub-family G member 2transporter
DB05294VandetanibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB05294VandetanibDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB05294VandetanibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB05294VandetanibProtein-tyrosine kinase 6target
DB05294VandetanibAngiopoietin-1 receptortarget
DB05294VandetanibAlpha-1-acid glycoprotein 1carrier
DB05294VandetanibSerum albumincarrier
DB05294VandetanibCytochrome P450 3A4enzyme
DB06616BosutinibBreakpoint cluster region proteintarget
DB06616BosutinibTyrosine-protein kinase ABL1target
DB06616BosutinibTyrosine-protein kinase Lyntarget
DB06616BosutinibTyrosine-protein kinase HCKtarget
DB06616BosutinibProto-oncogene tyrosine-protein kinase Srctarget
DB06616BosutinibMultidrug resistance protein 1transporter
DB06616BosutinibCytochrome P450 3A4enzyme
DB06616BosutinibCyclin-dependent kinase 2target
DB06616BosutinibDual specificity mitogen-activated protein kinase kinase 1target
DB06616BosutinibDual specificity mitogen-activated protein kinase kinase 2target
DB06616BosutinibMitogen-activated protein kinase kinase kinase 2target
DB06616BosutinibCalcium/calmodulin-dependent protein kinase type II subunit gammatarget
DB06616BosutinibCYP3Aenzyme
DB06616BosutinibCytochrome P450 2C8enzyme
DB09079NintedanibVascular endothelial growth factor receptor 1target
DB09079NintedanibVascular endothelial growth factor receptor 2target
DB09079NintedanibVascular endothelial growth factor receptor 3target
DB09079NintedanibPlatelet derived growth factor receptor alphatarget
DB09079NintedanibPlatelet derived growth factor receptor betatarget
DB09079NintedanibFibroblast growth factor receptor 1target
DB09079NintedanibFibroblast growth factor receptor 2target
DB09079NintedanibFibroblast growth factor receptor 3target
DB09079NintedanibReceptor-type tyrosine-protein kinase FLT3target
DB09079NintedanibTyrosine-protein kinase Lcktarget
DB09079NintedanibTyrosine-protein kinase Lyntarget
DB09079NintedanibProto-oncogene tyrosine-protein kinase Srctarget
DB09079NintedanibMultidrug resistance protein 1transporter
DB12010FostamatinibAdenosine receptor A3target
DB12010Fostamatinibvesicular monoamine transporter 2 (VMAT2)target
DB12010FostamatinibFatty-acid amide hydrolase 1target
DB12010FostamatinibEquilibrative nucleoside transporter 1target
DB12010FostamatinibUDP-glucuronosyltransferase 1-1target
DB12010FostamatinibcGMP-specific 3',5'-cyclic phosphodiesterasetarget
DB12010FostamatinibArachidonate 5-lipoxygenasetarget
DB12010FostamatinibCathepsin Starget
DB12010FostamatinibCathepsin L1target
DB12010FostamatinibTyrosine-protein kinase ABL1target
DB12010FostamatinibCalcium-dependent protein kinase 1target
DB12010FostamatinibSerine/threonine-protein kinase PknBtarget
DB12010FostamatinibRibosomal protein S6 kinase alpha-6target
DB12010FostamatinibNon-receptor tyrosine-protein kinase TYK2target
DB12010FostamatinibAtypical kinase COQ8A, mitochondrialtarget
DB12010FostamatinibTyrosine-protein kinase JAK1target
DB12010FostamatinibHepatocyte growth factor receptortarget
DB12010FostamatinibSerine/threonine-protein kinase NIM1target
DB12010FostamatinibSerine/threonine-protein kinase MST4target
DB12010FostamatinibcAMP-dependent protein kinase catalytic subunit alphatarget
DB12010FostamatinibSerine/threonine-protein kinase 24target
DB12010FostamatinibSerine/threonine-protein kinase 3target
DB12010FostamatinibTyrosine-protein kinase Tectarget
DB12010FostamatinibTyrosine-protein kinase SYKtarget
DB12010FostamatinibSerine/threonine-protein kinase 33target
DB12010FostamatinibSerine/threonine-protein kinase 35target
DB12010FostamatinibSerine/threonine-protein kinase 36target
DB12010FostamatinibSerine/threonine-protein kinase 38target
DB12010FostamatinibSerine/threonine-protein kinase 38-liketarget
DB12010FostamatinibSTE20/SPS1-related proline-alanine-rich protein kinasetarget
DB12010FostamatinibSerine/threonine-protein kinase TAO1target
DB12010FostamatinibSerine/threonine-protein kinase TAO2target
DB12010FostamatinibSerine/threonine-protein kinase TAO3target
DB12010FostamatinibSerine/threonine-protein kinase TBK1target
DB12010FostamatinibAngiopoietin-1 receptortarget
DB12010FostamatinibDual specificity testis-specific protein kinase 1target
DB12010FostamatinibTGF-beta receptor type-1target
DB12010FostamatinibTGF-beta receptor type-2target
DB12010FostamatinibTyrosine-protein kinase receptor Tie-1target
DB12010FostamatinibSerine/threonine-protein kinase tousled-like 1target
DB12010FostamatinibSerine/threonine-protein kinase tousled-like 2target
DB12010FostamatinibTRAF2 and NCK-interacting protein kinasetarget
DB12010FostamatinibNon-receptor tyrosine-protein kinase TNK1target
DB12010FostamatinibActivated CDC42 kinase 1target
DB12010FostamatinibSerine/threonine-protein kinase TNNI3Ktarget
DB12010FostamatinibTestis-specific serine/threonine-protein kinase 1target
DB12010FostamatinibDual specificity protein kinase TTKtarget
DB12010FostamatinibTyrosine-protein kinase TXKtarget
DB12010FostamatinibTyrosine-protein kinase receptor TYRO3target
DB12010FostamatinibSerine/threonine-protein kinase ULK1target
DB12010FostamatinibSerine/threonine-protein kinase ULK2target
DB12010FostamatinibSerine/threonine-protein kinase ULK3target
DB12010FostamatinibWee1-like protein kinasetarget
DB12010FostamatinibTyrosine-protein kinase Yestarget
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 19target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase MLTtarget
DB12010FostamatinibTyrosine-protein kinase ZAP-70target
DB12010FostamatinibAP2-associated protein kinase 1target
DB12010FostamatinibAbelson tyrosine-protein kinase 2target
DB12010FostamatinibActivin receptor type-1target
DB12010FostamatinibActivin receptor type-1Btarget
DB12010FostamatinibAtypical kinase COQ8B, mitochondrialtarget
DB12010FostamatinibALK tyrosine kinase receptortarget
DB12010FostamatinibAnkyrin repeat and protein kinase domain-containing protein 1target
DB12010FostamatinibAurora kinase Atarget
DB12010FostamatinibAurora kinase Btarget
DB12010FostamatinibAurora kinase Ctarget
DB12010FostamatinibTyrosine-protein kinase receptor UFOtarget
DB12010FostamatinibTyrosine-protein kinase Blktarget
DB12010FostamatinibBMP-2-inducible protein kinasetarget
DB12010FostamatinibBone morphogenetic protein receptor type-1Btarget
DB12010FostamatinibBone morphogenetic protein receptor type-2target
DB12010FostamatinibCytoplasmic tyrosine-protein kinase BMXtarget
DB12010FostamatinibSerine/threonine-protein kinase B-raftarget
DB12010FostamatinibTyrosine-protein kinase BTKtarget
DB12010FostamatinibCalcium/calmodulin-dependent protein kinase type 1target
DB12010FostamatinibCalcium/calmodulin-dependent protein kinase type 1Dtarget
DB12010FostamatinibCalcium/calmodulin-dependent protein kinase type 1Gtarget
DB12010FostamatinibCalcium/calmodulin-dependent protein kinase type II subunit alphatarget
DB12010FostamatinibCalcium/calmodulin-dependent protein kinase type II subunit betatarget
DB12010FostamatinibCalcium/calmodulin-dependent protein kinase type II subunit deltatarget
DB12010FostamatinibCalcium/calmodulin-dependent protein kinase type II subunit gammatarget
DB12010FostamatinibCalcium/calmodulin-dependent protein kinase kinase 1target
DB12010FostamatinibCalcium/calmodulin-dependent protein kinase kinase 2target
DB12010FostamatinibPeripheral plasma membrane protein CASKtarget
DB12010FostamatinibKappa-caseintarget
DB12010FostamatinibCyclin-dependent kinase 1target
DB12010FostamatinibSerine/threonine-protein kinase MRCK gammatarget
DB12010FostamatinibCyclin-dependent kinase 4target
DB12010FostamatinibCyclin-dependent kinase-like 1target
DB12010FostamatinibCyclin-dependent kinase-like 2target
DB12010FostamatinibSerine/threonine-protein kinase Chk1target
DB12010FostamatinibSerine/threonine-protein kinase Chk2target
DB12010FostamatinibCitron Rho-interacting kinasetarget
DB12010FostamatinibDual specificity protein kinase CLK1target
DB12010FostamatinibDual specificity protein kinase CLK2target
DB12010FostamatinibDual specificity protein kinase CLK3target
DB12010FostamatinibDual specificity protein kinase CLK4target
DB12010FostamatinibMacrophage colony-stimulating factor 1 receptortarget
DB12010FostamatinibTyrosine-protein kinase CSKtarget
DB12010FostamatinibCasein kinase I isoform alphatarget
DB12010FostamatinibCasein kinase II subunit alphatarget
DB12010FostamatinibCasein kinase II subunit alpha'target
DB12010FostamatinibDeath-associated protein kinase 1target
DB12010FostamatinibDeath-associated protein kinase 2target
DB12010FostamatinibDeath-associated protein kinase 3target
DB12010FostamatinibSerine/threonine-protein kinase DCLK1target
DB12010FostamatinibSerine/threonine-protein kinase DCLK2target
DB12010FostamatinibSerine/threonine-protein kinase DCLK3target
DB12010FostamatinibEpithelial discoidin domain-containing receptor 1target
DB12010FostamatinibDiscoidin domain-containing receptor 2target
DB12010FostamatinibDual specificity tyrosine-phosphorylation-regulated kinase 1Atarget
DB12010FostamatinibDual specificity tyrosine-phosphorylation-regulated kinase 1Btarget
DB12010FostamatinibEpidermal growth factor receptortarget
DB12010FostamatinibEukaryotic translation initiation factor 2-alpha kinase 1target
DB12010FostamatinibInterferon-induced, double-stranded RNA-activated protein kinasetarget
DB12010FostamatinibeIF-2-alpha kinase GCN2target
DB12010FostamatinibEphrin type-A receptor 1target
DB12010FostamatinibEphrin type-A receptor 2target
DB12010FostamatinibEphrin type-A receptor 3target
DB12010FostamatinibEphrin type-A receptor 4target
DB12010FostamatinibEphrin type-A receptor 5target
DB12010FostamatinibEphrin type-A receptor 6target
DB12010FostamatinibEphrin type-A receptor 7target
DB12010FostamatinibEphrin type-A receptor 8target
DB12010FostamatinibEphrin type-B receptor 1target
DB12010FostamatinibEphrin type-B receptor 2target
DB12010FostamatinibEphrin type-B receptor 4target
DB12010FostamatinibEphrin type-B receptor 6target
DB12010FostamatinibReceptor tyrosine-protein kinase erbB-2target
DB12010FostamatinibReceptor tyrosine-protein kinase erbB-4target
DB12010FostamatinibSerine/threonine-protein kinase/endoribonuclease IRE1target
DB12010FostamatinibTyrosine-protein kinase Fertarget
DB12010FostamatinibTyrosine-protein kinase Fes/Fpstarget
DB12010FostamatinibFibroblast growth factor receptor 1target
DB12010FostamatinibFibroblast growth factor receptor 2target
DB12010FostamatinibFibroblast growth factor receptor 3target
DB12010FostamatinibTyrosine-protein kinase Fgrtarget
DB12010FostamatinibVascular endothelial growth factor receptor 1target
DB12010FostamatinibReceptor-type tyrosine-protein kinase FLT3target
DB12010FostamatinibVascular endothelial growth factor receptor 3target
DB12010FostamatinibSerine/threonine-protein kinase mTORtarget
DB12010FostamatinibTyrosine-protein kinase FRKtarget
DB12010FostamatinibTyrosine-protein kinase Fyntarget
DB12010FostamatinibCyclin-G-associated kinasetarget
DB12010FostamatinibGlycogen synthase kinase-3 alphatarget
DB12010FostamatinibGlycogen synthase kinase-3 betatarget
DB12010FostamatinibTyrosine-protein kinase HCKtarget
DB12010FostamatinibHomeodomain-interacting protein kinase 2target
DB12010FostamatinibHomeodomain-interacting protein kinase 3target
DB12010FostamatinibSerine/threonine-protein kinase ICKtarget
DB12010FostamatinibInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB12010FostamatinibInhibitor of nuclear factor kappa-B kinase subunit epsilontarget
DB12010FostamatinibInsulin receptortarget
DB12010FostamatinibInsulin receptor-related proteintarget
DB12010FostamatinibInterleukin-1 receptor-associated kinase 1target
DB12010FostamatinibInterleukin-1 receptor-associated kinase 3target
DB12010FostamatinibInterleukin-1 receptor-associated kinase 4target
DB12010FostamatinibTyrosine-protein kinase ITK/TSKtarget
DB12010FostamatinibTyrosine-protein kinase JAK2target
DB12010FostamatinibTyrosine-protein kinase JAK3target
DB12010FostamatinibVascular endothelial growth factor receptor 2target
DB12010FostamatinibSerine/threonine-protein kinase SIK3target
DB12010FostamatinibMast/stem cell growth factor receptor Kittarget
DB12010FostamatinibSerine/threonine-protein kinase LATS1target
DB12010FostamatinibTyrosine-protein kinase Lcktarget
DB12010FostamatinibLIM domain kinase 1target
DB12010FostamatinibLIM domain kinase 2target
DB12010FostamatinibLeucine-rich repeat serine/threonine-protein kinase 2target
DB12010FostamatinibLeukocyte tyrosine kinase receptortarget
DB12010FostamatinibTyrosine-protein kinase Lyntarget
DB12010FostamatinibDual specificity mitogen-activated protein kinase kinase 2target
DB12010FostamatinibDual specificity mitogen-activated protein kinase kinase 3target
DB12010FostamatinibDual specificity mitogen-activated protein kinase kinase 5target
DB12010FostamatinibDual specificity mitogen-activated protein kinase kinase 6target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 1target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 10target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 11target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 12target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 13target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 15target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 2target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 3target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 4target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 6target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 9target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase kinase 1target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase kinase 2target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase kinase 3target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase kinase 4target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase kinase 5target
DB12010FostamatinibMitogen-activated protein kinase 10target
DB12010FostamatinibMitogen-activated protein kinase 13target
DB12010FostamatinibMitogen-activated protein kinase 14target
DB12010FostamatinibMitogen-activated protein kinase 15target
DB12010FostamatinibMitogen-activated protein kinase 4target
DB12010FostamatinibMitogen-activated protein kinase 7target
DB12010FostamatinibMitogen-activated protein kinase 9target
DB12010FostamatinibMAP kinase-activated protein kinase 5target
DB12010FostamatinibSerine/threonine-protein kinase MARK1target
DB12010FostamatinibSerine/threonine-protein kinase MARK2target
DB12010FostamatinibMAP/microtubule affinity-regulating kinase 3target
DB12010FostamatinibMAP/microtubule affinity-regulating kinase 4target
DB12010FostamatinibCLIP-associating protein 1target
DB12010FostamatinibMicrotubule-associated serine/threonine-protein kinase 1target
DB12010FostamatinibMegakaryocyte-associated tyrosine-protein kinasetarget
DB12010FostamatinibMaternal embryonic leucine zipper kinasetarget
DB12010FostamatinibTyrosine-protein kinase Mertarget
DB12010FostamatinibMisshapen-like kinase 1target
DB12010FostamatinibMAP kinase-interacting serine/threonine-protein kinase 1target
DB12010FostamatinibMAP kinase-interacting serine/threonine-protein kinase 2target
DB12010FostamatinibMacrophage-stimulating protein receptortarget
DB12010FostamatinibMuscle, skeletal receptor tyrosine-protein kinasetarget
DB12010FostamatinibMyosin light chain kinase, smooth muscletarget
DB12010FostamatinibMyosin light chain kinase 2, skeletal/cardiac muscletarget
DB12010FostamatinibMyosin light chain kinase 3target
DB12010FostamatinibMyosin light chain kinase family member 4target
DB12010FostamatinibMyosin-IIIatarget
DB12010FostamatinibSerine/threonine-protein kinase Nek1target
DB12010FostamatinibSerine/threonine-protein kinase Nek11target
DB12010FostamatinibSerine/threonine-protein kinase Nek2target
DB12010FostamatinibSerine/threonine-protein kinase Nek3target
DB12010FostamatinibSerine/threonine-protein kinase Nek4target
DB12010FostamatinibSerine/threonine-protein kinase Nek5target
DB12010FostamatinibSerine/threonine-protein kinase Nek9target
DB12010FostamatinibHigh affinity nerve growth factor receptortarget
DB12010FostamatinibBDNF/NT-3 growth factors receptortarget
DB12010FostamatinibNT-3 growth factor receptortarget
DB12010FostamatinibNUAK family SNF1-like kinase 1target
DB12010FostamatinibNUAK family SNF1-like kinase 2target
DB12010FostamatinibSerine/threonine-protein kinase OSR1target
DB12010FostamatinibSerine/threonine-protein kinase PAK 1target
DB12010FostamatinibSerine/threonine-protein kinase PAK 2target
DB12010FostamatinibSerine/threonine-protein kinase PAK 3target
DB12010FostamatinibSerine/threonine-protein kinase PAK 4target
DB12010FostamatinibSerine/threonine-protein kinase PAK 6target
DB12010FostamatinibSerine/threonine-protein kinase PAK 5target
DB12010FostamatinibCyclin-dependent kinase 16target
DB12010FostamatinibCyclin-dependent kinase 17target
DB12010FostamatinibPlatelet-derived growth factor receptor alphatarget
DB12010FostamatinibPlatelet-derived growth factor receptor betatarget
DB12010Fostamatinib3-phosphoinositide-dependent protein kinase 1target
DB12010FostamatinibCyclin-dependent kinase 15target
DB12010FostamatinibPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoformtarget
DB12010FostamatinibPhosphatidylinositol 4-kinase betatarget
DB12010FostamatinibPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit betatarget
DB12010FostamatinibPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gammatarget
DB12010FostamatinibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
DB12010FostamatinibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformtarget
DB12010FostamatinibSerine/threonine-protein kinase pim-1target
DB12010FostamatinibSerine/threonine-protein kinase pim-3target
DB12010FostamatinibPhosphatidylinositol 5-phosphate 4-kinase type-2 betatarget
DB12010FostamatinibPhosphatidylinositol 5-phosphate 4-kinase type-2 gammatarget
DB12010FostamatinibMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinasetarget
DB12010FostamatinibSerine/threonine-protein kinase N1target
DB12010FostamatinibSerine/threonine-protein kinase N2target
DB12010FostamatinibSerine/threonine-protein kinase PLK1target
DB12010FostamatinibSerine/threonine-protein kinase PLK2target
DB12010FostamatinibSerine/threonine-protein kinase PLK3target
DB12010FostamatinibSerine/threonine-protein kinase PLK4target
DB12010Fostamatinib5'-AMP-activated protein kinase catalytic subunit alpha-1target
DB12010Fostamatinib5'-AMP-activated protein kinasetarget
DB12010FostamatinibcAMP-dependent protein kinase catalytic subunit betatarget
DB12010FostamatinibProtein kinase C delta typetarget
DB12010FostamatinibProtein kinase C epsilon typetarget
DB12010FostamatinibProtein kinase C gamma typetarget
DB12010FostamatinibProtein kinase C iota typetarget
DB12010FostamatinibProtein kinase C theta typetarget
DB12010FostamatinibSerine/threonine-protein kinase D1target
DB12010FostamatinibcGMP-dependent protein kinase 2target
DB12010FostamatinibSerine/threonine-protein kinase PRP4 homologtarget
DB12010FostamatinibFocal adhesion kinase 1target
DB12010FostamatinibProtein-tyrosine kinase 2-betatarget
DB12010FostamatinibProtein-tyrosine kinase 6target
DB12010FostamatinibRAF proto-oncogene serine/threonine-protein kinasetarget
DB12010FostamatinibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB12010FostamatinibSerine/threonine-protein kinase RIO1target
DB12010FostamatinibSerine/threonine-protein kinase RIO2target
DB12010FostamatinibSerine/threonine-protein kinase RIO3target
DB12010FostamatinibReceptor-interacting serine/threonine-protein kinase 1target
DB12010FostamatinibReceptor-interacting serine/threonine-protein kinase 2target
DB12010FostamatinibReceptor-interacting serine/threonine-protein kinase 4target
DB12010FostamatinibRho-associated protein kinase 2target
DB12010FostamatinibProto-oncogene tyrosine-protein kinase ROStarget
DB12010FostamatinibRibosomal protein S6 kinase alpha-1target
DB12010FostamatinibRibosomal protein S6 kinase alpha-3target
DB12010FostamatinibSerine/threonine-protein kinase SBK1target
DB12010FostamatinibUncharacterized serine/threonine-protein kinase SBK3target
DB12010FostamatinibSerine/threonine-protein kinase Sgk3target
DB12010FostamatinibSerine/threonine-protein kinase SIK1target
DB12010FostamatinibSerine/threonine-protein kinase SIK2target
DB12010FostamatinibSTE20-like serine/threonine-protein kinasetarget
DB12010FostamatinibSNF-related serine/threonine-protein kinasetarget
DB12010FostamatinibProto-oncogene tyrosine-protein kinase Srctarget
DB12010FostamatinibTyrosine-protein kinase Srmstarget
DB12010FostamatinibSerine/threonine-protein kinase 10target
DB12010FostamatinibSerine/threonine-protein kinase 16target
DB12010FostamatinibSerine/threonine-protein kinase 17Atarget
DB12010FostamatinibSerine/threonine-protein kinase 17Btarget
DB12010FostamatinibSerine/threonine-protein kinase 32Atarget
DB12010FostamatinibCytochrome P450 3A4enzyme
DB12010FostamatinibATP-binding cassette sub-family G member 2transporter
DB12010FostamatinibATP-binding cassette sub-family B member 5transporter
DB12010FostamatinibUDP-glucuronosyltransferase 1-9enzyme
DB11703AcalabrutinibTyrosine-protein kinase BTKtarget
DB11703AcalabrutinibCytochrome P450 3A4enzyme
DB11703AcalabrutinibCytochrome P450 3A5enzyme
DB11703AcalabrutinibCYP3Aenzyme
DB08901PonatinibTyrosine-protein kinase ABL1target
DB08901PonatinibBreakpoint cluster region proteintarget
DB08901PonatinibMast/stem cell growth factor receptor Kittarget
DB08901PonatinibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB08901PonatinibAngiopoietin-1 receptortarget
DB08901PonatinibReceptor-type tyrosine-protein kinase FLT3target
DB08901PonatinibCytochrome P450 3A4enzyme
DB08901PonatinibCytochrome P450 2C8enzyme
DB08901PonatinibCytochrome P450 2D6enzyme
DB08901PonatinibCytochrome P450 3A5enzyme
DB08901PonatinibMultidrug resistance protein 1transporter
DB08901PonatinibATP-binding cassette sub-family G member 2transporter
DB08901PonatinibFibroblast growth factor receptor 1target
DB08901PonatinibFibroblast growth factor receptor 2target
DB08901PonatinibFibroblast growth factor receptor 3target
DB08901PonatinibFibroblast growth factor receptor 4target
DB08901PonatinibTyrosine-protein kinase Lcktarget
DB08901PonatinibProto-oncogene tyrosine-protein kinase Srctarget
DB08901PonatinibTyrosine-protein kinase Lyntarget
DB08901PonatinibVascular endothelial growth factor receptor 2target
DB08901PonatinibPlatelet-derived growth factor receptor alphatarget
DB08916AfatinibEpidermal growth factor receptortarget
DB08916AfatinibReceptor tyrosine-protein kinase erbB-2target
DB08916AfatinibReceptor tyrosine-protein kinase erbB-4target
DB08916AfatinibMultidrug resistance protein 1transporter
DB08916AfatinibATP-binding cassette sub-family G member 2transporter
DB04849CediranibVascular endothelial growth factor receptor 2target
DB05928DovitinibCytochrome P450 1A1enzyme
DB05928DovitinibCytochrome P450 1A2enzyme
DB05928DovitinibCanalicular multispecific organic anion transporter 2transporter
DB05928DovitinibATP-binding cassette sub-family G member 2transporter
DB05928DovitinibUDP-glucuronosyltransferase 1-3enzyme
DB05928DovitinibUDP-glucuronosyltransferase 2B7enzyme
DB05928DovitinibNuclear receptor subfamily 1 group I member 2target
DB05928DovitinibSolute carrier organic anion transporter family member 1B1transporter
DB05928DovitinibSolute carrier organic anion transporter family member 2B1transporter
DB05928DovitinibCytochrome P450 2C19enzyme
DB05928DovitinibCytochrome P450 3A4enzyme
DB05928DovitinibSolute carrier organic anion transporter family member 1B3transporter
DB05928DovitinibMultidrug resistance protein 1transporter
DB09078LenvatinibVascular endothelial growth factor receptor 1target
DB09078LenvatinibVascular endothelial growth factor receptor 2target
DB09078LenvatinibVascular endothelial growth factor receptor 3target
DB09078LenvatinibFibroblast growth factor receptor 1target
DB09078LenvatinibFibroblast growth factor receptor 2target
DB09078LenvatinibFibroblast growth factor receptor 3target
DB09078LenvatinibFibroblast growth factor receptor 4target
DB09078LenvatinibPlatelet derived growth factor receptor alphatarget
DB09078LenvatinibRET target
DB09078LenvatinibMast/stem cell growth factor receptor Kittarget
DB09078LenvatinibMultidrug resistance protein 1transporter
DB09078LenvatinibATP-binding cassette sub-family G member 2transporter
DB09078LenvatinibCYP3Aenzyme
DB09078LenvatinibAldehyde oxidaseenzyme
DB09078LenvatinibCytochrome P450 2C8enzyme
DB09078LenvatinibCytochrome P450 2C9enzyme
DB09078LenvatinibCytochrome P450 1A2enzyme
DB09078LenvatinibCytochrome P450 2B6enzyme
DB09078LenvatinibCytochrome P450 2C19enzyme
DB09078LenvatinibSolute carrier family 22 member 6transporter
DB09078LenvatinibSolute carrier family 22 member 8transporter
DB09078LenvatinibSolute carrier family 22 member 1transporter
DB09078LenvatinibSolute carrier family 22 member 2transporter
DB09078LenvatinibSolute carrier organic anion transporter family member 1B1transporter
DB09078LenvatinibBile salt export pumptransporter
DB09078LenvatinibCytochrome P450 2D6enzyme
DB08877RuxolitinibTyrosine-protein kinase JAK1target
DB08877RuxolitinibTyrosine-protein kinase JAK2target
DB08877RuxolitinibCytochrome P450 3A4enzyme
DB08865CrizotinibCytochrome P450 3A4enzyme
DB08865CrizotinibCytochrome P450 3A5enzyme
DB08865CrizotinibMultidrug resistance protein 1transporter
DB08865CrizotinibALK tyrosine kinase receptortarget
DB08865CrizotinibHepatocyte growth factor receptortarget
DB08865CrizotinibCytochrome P450 2B6enzyme
DB08865CrizotinibCYP3Aenzyme
DB06469LestaurtinibReceptor-type tyrosine-protein kinase FLT3target
DB06469LestaurtinibCYP3Aenzyme
DB11805SaracatinibCYP3Aenzyme
DB11363AlectinibALK tyrosine kinase receptortarget
DB11363AlectinibATP-binding cassette sub-family G member 2transporter
DB11363AlectinibMultidrug resistance protein 1carrier
DB12267BrigatinibALK tyrosine kinase receptortarget
DB12267BrigatinibEpidermal growth factor receptortarget
DB12267BrigatinibTyrosine-protein kinase ABL1target
DB12267BrigatinibInsulin-like growth factor 1 receptortarget
DB12267BrigatinibReceptor-type tyrosine-protein kinase FLT3target
DB12267BrigatinibCytochrome P450 2C8enzyme
DB12267BrigatinibCytochrome P450 3A4enzyme
DB12267BrigatinibInsulin receptortarget
DB12267BrigatinibHepatocyte growth factor receptortarget
DB12267BrigatinibReceptor tyrosine-protein kinase erbB-4target
DB12267BrigatinibReceptor tyrosine-protein kinase erbB-2target
DB12267BrigatinibATP-binding cassette sub-family B member 5transporter
DB12267BrigatinibATP-binding cassette sub-family G member 2transporter
DB12267BrigatinibSolute carrier family 22 member 1transporter
DB12267BrigatinibMultidrug and toxin extrusion protein 1transporter
DB12267BrigatinibMultidrug and toxin extrusion protein 2transporter
DB12267BrigatinibCYP3Aenzyme
DB09063CeritinibALK tyrosine kinase receptortarget
DB09063CeritinibMultidrug resistance protein 1transporter
DB09063CeritinibCytochrome P450 2C9enzyme
DB09063CeritinibCYP3Aenzyme
DB06595MidostaurinProtein kinase C alpha typetarget
DB06595MidostaurinVascular endothelial growth factor receptor 2target
DB06595MidostaurinMast/stem cell growth factor receptor Kittarget
DB06595MidostaurinPlatelet-derived growth factor receptor alphatarget
DB06595MidostaurinPlatelet-derived growth factor receptor betatarget
DB06595MidostaurinReceptor-type tyrosine-protein kinase FLT3target
DB06595MidostaurinCYP3Aenzyme
DB06595MidostaurinCytochrome P450 1A2enzyme
DB06595MidostaurinCytochrome P450 2B6enzyme
DB06595MidostaurinCytochrome P450 2C8enzyme
DB06595MidostaurinCytochrome P450 2C9enzyme
DB06595MidostaurinCytochrome P450 2C19enzyme
DB06595MidostaurinCytochrome P450 2D6enzyme
DB06595MidostaurinCytochrome P450 2E1enzyme
DB06595MidostaurinCytochrome P450 3A4enzyme
DB06595MidostaurinCytochrome P450 3A5enzyme
DB06595MidostaurinCytochrome P450 3A7enzyme
DB06595MidostaurinCytochrome P450 3A43enzyme
DB11828NeratinibCytochrome P450 3A4enzyme
DB11828NeratinibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB11828NeratinibMultidrug resistance protein 1transporter
DB11828NeratinibEpidermal growth factor receptortarget
DB11828NeratinibSerum albumincarrier
DB11828Neratinibalpha1-acid glycoproteincarrier
DB09330OsimertinibEpidermal growth factor receptortarget
DB09330OsimertinibMultidrug resistance protein 1transporter
DB09330OsimertinibATP-binding cassette sub-family G member 2transporter
DB09330OsimertinibCytochrome P450 3A4enzyme
DB09330OsimertinibCytochrome P450 1A2enzyme
DB08896RegorafenibCytochrome P450 3A4enzyme
DB08896RegorafenibUDP-glucuronosyltransferase 1-9enzyme
DB08896RegorafenibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB08896RegorafenibVascular endothelial growth factor receptor 1target
DB08896RegorafenibVascular endothelial growth factor receptor 2target
DB08896RegorafenibVascular endothelial growth factor receptor 3target
DB08896RegorafenibMast/stem cell growth factor receptor Kittarget
DB08896RegorafenibPlatelet-derived growth factor receptor alphatarget
DB08896RegorafenibPlatelet-derived growth factor receptor betatarget
DB08896RegorafenibFibroblast growth factor receptor 1target
DB08896RegorafenibFibroblast growth factor receptor 2target
DB08896RegorafenibAngiopoietin-1 receptortarget
DB08896RegorafenibDiscoidin domain-containing receptor 2target
DB08896RegorafenibHigh affinity nerve growth factor receptortarget
DB08896RegorafenibEphrin type-A receptor 2target
DB08896RegorafenibRAF proto-oncogene serine/threonine-protein kinasetarget
DB08896RegorafenibSerine/threonine-protein kinase B-raftarget
DB08896RegorafenibCytochrome P450 2C8enzyme
DB08896RegorafenibCytochrome P450 2C9enzyme
DB08896RegorafenibCytochrome P450 2B6enzyme
DB08896RegorafenibCytochrome P450 2C19enzyme
DB08896RegorafenibMitogen-activated protein kinase 11target
DB08896RegorafenibTyrosine-protein kinase FRKtarget
DB08896RegorafenibTyrosine-protein kinase ABL1target
DB08896RegorafenibMultidrug resistance protein 1transporter
DB08896RegorafenibATP-binding cassette sub-family G member 2transporter
DB08896RegorafenibUDP-glucuronosyltransferase 1-1enzyme
DB05424CanertinibEpidermal growth factor receptortarget
DB12307ForetinibHepatocyte growth factortarget
DB12307ForetinibVascular endothelial growth factor receptor 2target
DB12307ForetinibCYP3Aenzyme
DB11737IcotinibEpidermal growth factor receptortarget
DB11737IcotinibCytochrome P450 3A4enzyme
DB11737IcotinibCytochrome P450 1A2enzyme
DB11737IcotinibCytochrome P450 3A5enzyme
DB12323RadotinibTyrosine-protein kinase ABL1target
DB11973TesevatinibPro-epidermal growth factortarget
DB11973TesevatinibEphrin type-B receptor 4target
DB11973TesevatinibReceptor tyrosine-protein kinase erbB-2target
DB04879VatalanibVascular endothelial growth factor receptor 1target
DB04879VatalanibVascular endothelial growth factor receptor 2target
DB04879VatalanibVascular endothelial growth factor receptor 3target