Radicicol

Identification

Name
Radicicol
Accession Number
DB03758  (EXPT02763)
Type
Small Molecule
Groups
Experimental
Description
Not Available
Structure
Thumb
Synonyms
Not Available
External IDs
NSC-294404 / RADICICOL R-2146
Categories
UNII
I60EH8GECX
CAS number
Not Available
Weight
Average: 364.777
Monoisotopic: 364.071365983
Chemical Formula
C18H17ClO6
InChI Key
WYZWZEOGROVVHK-GTMNPGAYSA-N
InChI
InChI=1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1
IUPAC Name
(4R,6R,8R,9Z,11E)-16-chloro-17,19-dihydroxy-4-methyl-3,7-dioxatricyclo[13.4.0.0⁶,⁸]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione
SMILES
[H]/C1=C([H])\C(=O)CC2=C(C(O)=CC(O)=C2Cl)C(=O)O[C@]([H])(C)C[C@@]2([H])O[C@]2([H])/C([H])=C\1/[H]

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
UHeat shock protein HSP 90-betaNot AvailableHuman
UEndoplasminNot AvailableHuman
UDihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialNot AvailableHuman
U[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrialNot AvailableHuman
UVirulence sensor histidine kinase PhoQNot AvailableSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AcepromazineThe serum concentration of Acepromazine can be increased when it is combined with Radicicol.Approved, Vet Approved
AceprometazineThe serum concentration of Aceprometazine can be increased when it is combined with Radicicol.Approved
AgmatineThe therapeutic efficacy of Radicicol can be increased when used in combination with Agmatine.Experimental, Investigational
AlimemazineThe serum concentration of Alimemazine can be increased when it is combined with Radicicol.Approved, Vet Approved
AmiodaroneThe therapeutic efficacy of Radicicol can be increased when used in combination with Amiodarone.Approved, Investigational
Amphotericin BThe therapeutic efficacy of Amphotericin B can be decreased when used in combination with Radicicol.Approved, Investigational
AmrinoneThe therapeutic efficacy of Radicicol can be increased when used in combination with Amrinone.Approved
AranidipineThe therapeutic efficacy of Radicicol can be increased when used in combination with Aranidipine.Approved, Investigational
ArtemetherThe risk or severity of QTc prolongation can be increased when Radicicol is combined with Artemether.Approved
AzelnidipineThe therapeutic efficacy of Radicicol can be increased when used in combination with Azelnidipine.Approved, Investigational
AzimilideThe therapeutic efficacy of Radicicol can be increased when used in combination with Azimilide.Investigational
BarnidipineThe therapeutic efficacy of Radicicol can be increased when used in combination with Barnidipine.Approved
BencyclaneThe therapeutic efficacy of Radicicol can be increased when used in combination with Bencyclane.Experimental
BenidipineThe therapeutic efficacy of Radicicol can be increased when used in combination with Benidipine.Approved, Investigational
BepridilThe therapeutic efficacy of Radicicol can be increased when used in combination with Bepridil.Approved, Withdrawn
BioallethrinThe therapeutic efficacy of Radicicol can be increased when used in combination with Bioallethrin.Approved, Experimental
BL-1020The serum concentration of BL-1020 can be increased when it is combined with Radicicol.Investigational
BuspironeThe metabolism of Buspirone can be decreased when combined with Radicicol.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Radicicol.Approved, Investigational
CarboxyamidotriazoleThe therapeutic efficacy of Radicicol can be increased when used in combination with Carboxyamidotriazole.Investigational
CaroverineThe therapeutic efficacy of Radicicol can be increased when used in combination with Caroverine.Experimental
ChlorproethazineThe serum concentration of Chlorproethazine can be increased when it is combined with Radicicol.Experimental
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Radicicol.Approved, Investigational, Vet Approved
CilnidipineThe therapeutic efficacy of Radicicol can be increased when used in combination with Cilnidipine.Approved, Investigational
CinnarizineThe therapeutic efficacy of Radicicol can be increased when used in combination with Cinnarizine.Approved, Investigational
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Radicicol.Approved, Investigational, Withdrawn
ClevidipineThe therapeutic efficacy of Radicicol can be increased when used in combination with Clevidipine.Approved, Investigational
CyclandelateThe therapeutic efficacy of Radicicol can be increased when used in combination with Cyclandelate.Approved
DapsoneThe risk or severity of adverse effects can be increased when Radicicol is combined with Dapsone.Approved, Investigational
DarodipineThe therapeutic efficacy of Radicicol can be increased when used in combination with Darodipine.Experimental
DidanosineDidanosine can cause a decrease in the absorption of Radicicol resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Radicicol.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Radicicol.Approved, Investigational
DotarizineThe therapeutic efficacy of Radicicol can be increased when used in combination with Dotarizine.Investigational
EfonidipineThe therapeutic efficacy of Radicicol can be increased when used in combination with Efonidipine.Approved, Investigational
EperisoneThe therapeutic efficacy of Radicicol can be increased when used in combination with Eperisone.Approved, Investigational
EthosuximideThe therapeutic efficacy of Radicicol can be increased when used in combination with Ethosuximide.Approved
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Radicicol.Approved
FelodipineThe therapeutic efficacy of Radicicol can be increased when used in combination with Felodipine.Approved, Investigational
FendilineThe therapeutic efficacy of Radicicol can be increased when used in combination with Fendiline.Withdrawn
Fish oilThe therapeutic efficacy of Radicicol can be increased when used in combination with Fish oil.Approved, Nutraceutical
FlunarizineThe therapeutic efficacy of Radicicol can be increased when used in combination with Flunarizine.Approved
FluphenazineThe serum concentration of Fluphenazine can be increased when it is combined with Radicicol.Approved
FluspirileneThe therapeutic efficacy of Radicicol can be increased when used in combination with Fluspirilene.Approved, Investigational
FosphenytoinThe serum concentration of Radicicol can be decreased when it is combined with Fosphenytoin.Approved, Investigational
GabapentinThe therapeutic efficacy of Radicicol can be increased when used in combination with Gabapentin.Approved, Investigational
GallopamilThe therapeutic efficacy of Radicicol can be increased when used in combination with Gallopamil.Investigational
IsradipineThe therapeutic efficacy of Radicicol can be increased when used in combination with Isradipine.Approved, Investigational
LacidipineThe therapeutic efficacy of Radicicol can be increased when used in combination with Lacidipine.Approved, Investigational
LercanidipineThe therapeutic efficacy of Radicicol can be increased when used in combination with Lercanidipine.Approved, Investigational
LevetiracetamThe therapeutic efficacy of Radicicol can be increased when used in combination with Levetiracetam.Approved, Investigational
LidoflazineThe therapeutic efficacy of Radicicol can be increased when used in combination with Lidoflazine.Experimental
LoperamideThe therapeutic efficacy of Radicicol can be increased when used in combination with Loperamide.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Radicicol.Approved
LumefantrineThe risk or severity of QTc prolongation can be increased when Radicicol is combined with Lumefantrine.Approved
Magnesium sulfateThe therapeutic efficacy of Radicicol can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
ManidipineThe therapeutic efficacy of Radicicol can be increased when used in combination with Manidipine.Approved, Investigational
MentholThe therapeutic efficacy of Radicicol can be increased when used in combination with Menthol.Approved
MesoridazineThe serum concentration of Mesoridazine can be increased when it is combined with Radicicol.Approved, Investigational
MethotrimeprazineThe serum concentration of Methotrimeprazine can be increased when it is combined with Radicicol.Approved, Investigational
MethsuximideThe therapeutic efficacy of Radicicol can be increased when used in combination with Methsuximide.Approved
Methylene blueThe serum concentration of Methylene blue can be increased when it is combined with Radicicol.Approved, Investigational
MibefradilThe therapeutic efficacy of Radicicol can be increased when used in combination with Mibefradil.Investigational, Withdrawn
MoricizineThe serum concentration of Moricizine can be increased when it is combined with Radicicol.Approved, Investigational, Withdrawn
NaftopidilThe therapeutic efficacy of Radicicol can be increased when used in combination with Naftopidil.Investigational
NicardipineThe therapeutic efficacy of Radicicol can be increased when used in combination with Nicardipine.Approved, Investigational
NiguldipineThe therapeutic efficacy of Radicicol can be increased when used in combination with Niguldipine.Experimental
NiludipineThe therapeutic efficacy of Radicicol can be increased when used in combination with Niludipine.Experimental
NilvadipineThe therapeutic efficacy of Radicicol can be increased when used in combination with Nilvadipine.Approved, Investigational
NimesulideThe therapeutic efficacy of Radicicol can be increased when used in combination with Nimesulide.Approved, Investigational, Withdrawn
NimodipineThe therapeutic efficacy of Radicicol can be increased when used in combination with Nimodipine.Approved, Investigational
NisoldipineThe therapeutic efficacy of Radicicol can be increased when used in combination with Nisoldipine.Approved
NitrendipineThe therapeutic efficacy of Radicicol can be increased when used in combination with Nitrendipine.Approved, Investigational
NylidrinThe therapeutic efficacy of Radicicol can be increased when used in combination with Nylidrin.Approved
OtiloniumThe therapeutic efficacy of Radicicol can be increased when used in combination with Otilonium.Experimental, Investigational
PerazineThe serum concentration of Perazine can be increased when it is combined with Radicicol.Approved, Investigational
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Radicicol.Approved
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Radicicol.Approved, Vet Approved
PinaveriumThe therapeutic efficacy of Radicicol can be increased when used in combination with Pinaverium.Approved
PrenylamineThe therapeutic efficacy of Radicicol can be increased when used in combination with Prenylamine.Withdrawn
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Radicicol.Approved, Vet Approved
ProgesteroneThe absorption of Progesterone can be decreased when combined with Radicicol.Approved, Vet Approved
PromazineThe serum concentration of Promazine can be increased when it is combined with Radicicol.Approved, Vet Approved
PromethazineThe serum concentration of Promethazine can be increased when it is combined with Radicicol.Approved, Investigational
PropericiazineThe serum concentration of Propericiazine can be increased when it is combined with Radicicol.Approved, Investigational
PropiopromazineThe serum concentration of Propiopromazine can be increased when it is combined with Radicicol.Vet Approved
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Radicicol.Approved, Investigational
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Radicicol.Approved, Investigational
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Radicicol.Approved, Investigational
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Radicicol.Approved
RifapentineThe serum concentration of Rifapentine can be increased when it is combined with Radicicol.Approved, Investigational
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Radicicol.Approved, Investigational
SeletracetamThe therapeutic efficacy of Radicicol can be increased when used in combination with Seletracetam.Investigational
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Radicicol.Approved
SucralfateSucralfate can cause a decrease in the absorption of Radicicol resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
SunitinibThe metabolism of Sunitinib can be decreased when combined with Radicicol.Approved, Investigational
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Radicicol.Approved, Investigational
TerodilineThe therapeutic efficacy of Radicicol can be increased when used in combination with Terodiline.Experimental
TetrahydropalmatineThe therapeutic efficacy of Radicicol can be increased when used in combination with Tetrahydropalmatine.Investigational
ThiazinamThe serum concentration of Thiazinam can be increased when it is combined with Radicicol.Experimental
ThiethylperazineThe serum concentration of Thiethylperazine can be increased when it is combined with Radicicol.Withdrawn
ThioproperazineThe serum concentration of Thioproperazine can be increased when it is combined with Radicicol.Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Radicicol.Approved, Withdrawn
Tolfenamic AcidThe therapeutic efficacy of Radicicol can be increased when used in combination with Tolfenamic Acid.Approved, Investigational
TranilastThe therapeutic efficacy of Radicicol can be increased when used in combination with Tranilast.Approved, Investigational
TrifluoperazineThe serum concentration of Trifluoperazine can be increased when it is combined with Radicicol.Approved, Investigational
TriflupromazineThe serum concentration of Triflupromazine can be increased when it is combined with Radicicol.Approved, Vet Approved
TrimebutineThe therapeutic efficacy of Radicicol can be increased when used in combination with Trimebutine.Approved
TrimethadioneThe therapeutic efficacy of Radicicol can be increased when used in combination with Trimethadione.Approved
VemurafenibThe risk or severity of QTc prolongation can be increased when Vemurafenib is combined with Radicicol.Approved
VerapamilThe therapeutic efficacy of Radicicol can be increased when used in combination with Verapamil.Approved
VinpocetineThe therapeutic efficacy of Radicicol can be increased when used in combination with Vinpocetine.Investigational
WIN 55212-2The therapeutic efficacy of Radicicol can be increased when used in combination with WIN 55212-2.Experimental
ZiconotideThe therapeutic efficacy of Radicicol can be increased when used in combination with Ziconotide.Approved
ZonisamideThe therapeutic efficacy of Radicicol can be increased when used in combination with Zonisamide.Approved, Investigational
Food Interactions
Not Available

References

Synthesis Reference

Yukio Sugimura, Kimio Iino, Yoshio Tsujita, Yoko Shimada, Tomowo Kobayashi, Takeshi Kagasaki, "Radicicol derivatives, their preparation and their anti-tumor activity." U.S. Patent US5597846, issued September, 1979.

US5597846
General References
Not Available
External Links
PubChem Compound
6323491
PubChem Substance
46504837
ChemSpider
20137057
BindingDB
15361
ChEBI
556075
ChEMBL
CHEMBL414883
Therapeutic Targets Database
DNC001195
HET
RDC
Wikipedia
Radicicol
PDB Entries
1bgq / 1u0z / 2hkj / 2q8i / 2wer / 2zbk / 3cgy / 4egk

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.188 mg/mLALOGPS
logP3.22ALOGPS
logP3.68ChemAxon
logS-3.3ALOGPS
pKa (Strongest Acidic)7.02ChemAxon
pKa (Strongest Basic)-4.1ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area96.36 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity93.56 m3·mol-1ChemAxon
Polarizability34.58 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9938
Blood Brain Barrier+0.9051
Caco-2 permeable+0.6021
P-glycoprotein substrateNon-substrate0.6299
P-glycoprotein inhibitor INon-inhibitor0.8888
P-glycoprotein inhibitor IINon-inhibitor0.9838
Renal organic cation transporterNon-inhibitor0.9069
CYP450 2C9 substrateNon-substrate0.827
CYP450 2D6 substrateNon-substrate0.8152
CYP450 3A4 substrateNon-substrate0.5578
CYP450 1A2 substrateNon-inhibitor0.7194
CYP450 2C9 inhibitorNon-inhibitor0.7904
CYP450 2D6 inhibitorNon-inhibitor0.9256
CYP450 2C19 inhibitorNon-inhibitor0.8108
CYP450 3A4 inhibitorNon-inhibitor0.8086
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9777
Ames testNon AMES toxic0.6926
CarcinogenicityNon-carcinogens0.9116
BiodegradationNot ready biodegradable0.9858
Rat acute toxicity2.4787 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7902
hERG inhibition (predictor II)Non-inhibitor0.9691
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as hydroxybenzoic acid derivatives. These are compounds containing a hydroxybenzoic acid (or a derivative), which is a benzene ring bearing a carboxyl and a hydroxyl groups.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Benzoic acids and derivatives
Direct Parent
Hydroxybenzoic acid derivatives
Alternative Parents
1-hydroxy-2-unsubstituted benzenoids / Aryl chlorides / Vinylogous acids / Lactones / Cyclic ketones / Carboxylic acid esters / Oxacyclic compounds / Monocarboxylic acids and derivatives / Epoxides / Dialkyl ethers
show 3 more
Substituents
Dihydroxybenzoic acid / 1-hydroxy-2-unsubstituted benzenoid / Aryl chloride / Aryl halide / Vinylogous acid / Carboxylic acid ester / Ketone / Cyclic ketone / Lactone / Carboxylic acid derivative
show 14 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
cyclic ketone, epoxide, phenols, macrolide antibiotic, enone, monochlorobenzenes (CHEBI:556075)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Utp binding
Specific Function
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Under...
Gene Name
HSP90AB1
Uniprot ID
P08238
Uniprot Name
Heat shock protein HSP 90-beta
Molecular Weight
83263.475 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Virion binding
Specific Function
Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in...
Gene Name
HSP90B1
Uniprot ID
P14625
Uniprot Name
Endoplasmin
Molecular Weight
92468.06 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Dihydrolipoyllysine-residue acetyltransferase activity
Specific Function
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name
DLAT
Uniprot ID
P10515
Uniprot Name
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Molecular Weight
68996.03 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Pyruvate dehydrogenase (acetyl-transferring) kinase activity
Specific Function
Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucos...
Gene Name
PDK3
Uniprot ID
Q15120
Uniprot Name
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
Molecular Weight
46938.485 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]
Kind
Protein
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Pharmacological action
Unknown
General Function
Member of the two-component regulatory system PhoP/PhoQ which regulates the expression of genes involved in virulence, adaptation to acidic and low Mg(2+) environments and resistance to host defense antimicrobial peptides. Essential for intramacrophage survival of S.typhimurium. In low periplasmic Mg(2+), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), acts as a protein phosphatase that dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG. Essential for transcription of spiC inside macrophages by controlling the expression of the two-component regulatory system SsrB/SpiR (SsrA) and Pir at transcriptional and post-transcriptional levels respectively. Promotes expression of the two-component regulatory system PmrA/PmrB via activation of pmrD gene. Is required to attenuate bacterial growth within fibroblast cells and to enhance bacterial resistance to bile in intestinal cells. Negatively regulates prgH, which is required for invasion of epithelial cells. Involved in acid tolerance.
Specific Function
Atp binding
Gene Name
phoQ
Uniprot ID
P0DM80
Uniprot Name
Virulence sensor histidine kinase PhoQ
Molecular Weight
55466.19 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]

Drug created on June 13, 2005 07:24 / Updated on August 02, 2018 05:11