Identification

Name
Sunitinib
Accession Number
DB01268  (DB07417)
Type
Small Molecule
Groups
Approved, Investigational
Description

Sunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. Sunitinib inhibits cellular signaling by targeting multiple RTKs. These include all platelet-derived growth factor receptors (PDGF-R) and vascular endothelial growth factor receptors (VEGF-R). Sunitinib also inhibits KIT (CD117), the RTK that drives the majority of GISTs. In addition, sunitinib inhibits other RTKs including RET, CSF-1R, and flt3.

Structure
Thumb
Synonyms
  • Sunitinibum
External IDs
SU-011248 / SU-11248 / SU011248 / SU11248
Product Ingredients
IngredientUNIICASInChI Key
Sunitinib malateLVX8N1UT73341031-54-7LBWFXVZLPYTWQI-IPOVEDGCSA-N
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
SutentCapsule25 mgOralPfizer2006-07-19Not applicableEu
SutentCapsule12.5 mgOralPfizer2006-06-22Not applicableCanada
SutentCapsule12.5 mg/1OralPfizer Laboratories Div Pfizer Inc.2006-01-26Not applicableUs
SutentCapsule37.5 mgOralPfizerNot applicableNot applicableCanada
SutentCapsule50 mg/1OralPfizer Laboratories Div Pfizer Inc.2006-01-26Not applicableUs
SutentCapsule37.5 mgOralPfizer2006-07-19Not applicableEu
SutentCapsule50 mgOralPfizer2006-07-19Not applicableEu
SutentCapsule50 mgOralPfizer2006-07-19Not applicableEu
SutentCapsule25 mgOralPfizer2006-06-22Not applicableCanada
SutentCapsule25 mg/1OralPfizer Laboratories Div Pfizer Inc.2006-01-26Not applicableUs
Categories
UNII
V99T50803M
CAS number
557795-19-4
Weight
Average: 398.4738
Monoisotopic: 398.211804333
Chemical Formula
C22H27FN4O2
InChI Key
WINHZLLDWRZWRT-ATVHPVEESA-N
InChI
InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
IUPAC Name
N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide
SMILES
CCN(CC)CCNC(=O)C1=C(C)NC(\C=C2/C(=O)NC3=C2C=C(F)C=C3)=C1C

Pharmacology

Indication

For the treatment of advanced renal cell carcinoma as well as the treatment of gastrointestinal stromal tumor after disease progression on or intolerance to imatinib mesylate.

Structured Indications
Pharmacodynamics

Sunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA on January 26, 2006.

Mechanism of action

Sunitinib is a small molecule that inhibits multiple RTKs, some of which are implicated in tumor growth, pathologic angiogenesis, and metastatic progression of cancer. Sunitinib was evaluated for its inhibitory activity against a variety of kinases (>80 kinases) and was identified as an inhibitor of platelet-derived growth factor receptors (PDGFRa and PDGFRb), vascular endothelial growth factor receptors (VEGFR1, VEGFR2 and VEGFR3), stem cell factor receptor (KIT), Fms-like tyrosine kinase-3 (FLT3), colony stimulating factor receptor Type 1 (CSF-1R), and the glial cell-line derived neurotrophic factor receptor (RET). Sunitinib inhibition of the activity of these RTKs has been demonstrated in biochemical and cellular assays, and inhibition of function has been demonstrated in cell proliferation assays. The primary metabolite exhibits similar potency compared to sunitinib in biochemical and cellular assays.

TargetActionsOrganism
APlatelet-derived growth factor receptor beta
inhibitor
Human
AVascular endothelial growth factor receptor 1
inhibitor
Human
AMast/stem cell growth factor receptor Kit
inhibitor
Human
AVascular endothelial growth factor receptor 2
inhibitor
Human
AVascular endothelial growth factor receptor 3
inhibitor
Human
AReceptor-type tyrosine-protein kinase FLT3
inhibitor
Human
AMacrophage colony-stimulating factor 1 receptor
inhibitor
Human
APlatelet-derived growth factor receptor alpha
inhibitor
Human
Absorption

Maximum plasma concentrations (Cmax) of sunitinib are generally observed between 6 and 12 hours (Tmax) following oral administration. Food has no effect on the bioavailability of sunitinib. Sunitinib may be taken with or without food. The pharmacokinetics were similar in healthy volunteers and in the solid tumor patient populations tested, including patients with GIST and RCC.

Volume of distribution
  • 2230 L (apparent volume of distribution, Vd/F)
Protein binding

Binding of sunitinib and its primary metabolite to human plasma protein in vitro was 95% and 90%, respectively.

Metabolism

Sunitinib is metabolized primarily by the cytochrome P450 enzyme, CYP3A4, to produce its primary active metabolite, which is further metabolized by CYP3A4.

Route of elimination

Sunitinib is metabolized primarily by the cytochrome P450 enzyme, CYP3A4, to produce its primary active metabolite, which is further metabolized by CYP3A4. Elimination is primarily via feces. In a human mass balance study of [14C]sunitinib, 61% of the dose was eliminated in feces, with renal elimination accounting for 16% of the administered dose.

Half life

Following administration of a single oral dose in healthy volunteers, the terminal half-lives of sunitinib and its primary active metabolite are approximately 40 to 60 hours and 80 to 110 hours, respectively.

Clearance
  • 34 - 62 L/h [Total oral clearance]
Toxicity

The maximally tolerated dose for rat, mouse, and dog when given orally is greater than 500 mg/kg. The maximally tolerated dose of a non-human primate is greater 1200 mg/kg.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Interacting Gene/EnzymeAllele nameGenotype(s)Defining Change(s)Type(s)DescriptionDetails
Cytochrome P450 3A4---(A;A) / (A;G)G > AADR Directly StudiedPatients with metastatic renal cell carcinoma who carry this polymorphism in CYP3A4 are at a higher risk of experiencing drug-induced hypertension when treated with sunitinib.Details

Interactions

Drug Interactions
DrugInteractionDrug group
2-HYDROXY-1,4-NAPHTHOQUINONEThe metabolism of Sunitinib can be decreased when combined with 2-HYDROXY-1,4-NAPHTHOQUINONE.Experimental
2-mercaptobenzothiazoleThe metabolism of Sunitinib can be decreased when combined with 2-mercaptobenzothiazole.Vet Approved
2,4-thiazolidinedione2,4-thiazolidinedione may increase the hypoglycemic activities of Sunitinib.Investigational
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the hypoglycemic activities of Sunitinib.Experimental
AcarboseAcarbose may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
AcetohexamideAcetohexamide may increase the hypoglycemic activities of Sunitinib.Investigational, Withdrawn
AcetyldigitoxinAcetyldigitoxin may decrease the cardiotoxic activities of Sunitinib.Approved
AcetyldigoxinAcetyldigoxin may decrease the cardiotoxic activities of Sunitinib.Experimental
Acetylsalicylic acidAcetylsalicylic acid may increase the hypoglycemic activities of Sunitinib.Approved, Vet Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Sunitinib.Approved
AICA ribonucleotideAICA ribonucleotide may increase the hypoglycemic activities of Sunitinib.Experimental, Investigational
AlaproclateAlaproclate may increase the hypoglycemic activities of Sunitinib.Experimental
AllicinAllicin may increase the hypoglycemic activities of Sunitinib.Investigational
AlogliptinAlogliptin may increase the hypoglycemic activities of Sunitinib.Approved
AloxiprinAloxiprin may increase the hypoglycemic activities of Sunitinib.Experimental
Aminosalicylic AcidAminosalicylic Acid may increase the hypoglycemic activities of Sunitinib.Approved
AmiodaroneThe metabolism of Sunitinib can be decreased when combined with Amiodarone.Approved, Investigational
AmorolfineThe metabolism of Sunitinib can be decreased when combined with Amorolfine.Approved, Investigational
AmphetamineAmphetamine may increase the hypoglycemic activities of Sunitinib.Approved, Illicit
Amphotericin BThe metabolism of Sunitinib can be decreased when combined with Amphotericin B.Approved, Investigational
AnagrelideSunitinib may increase the QTc-prolonging activities of Anagrelide.Approved
AnidulafunginThe metabolism of Sunitinib can be decreased when combined with Anidulafungin.Approved, Investigational
AprepitantThe serum concentration of Sunitinib can be increased when it is combined with Aprepitant.Approved, Investigational
Arsenic trioxideSunitinib may increase the QTc-prolonging activities of Arsenic trioxide.Approved, Investigational
ArtemetherThe metabolism of Sunitinib can be decreased when combined with Artemether.Approved
AsenapineSunitinib may increase the QTc-prolonging activities of Asenapine.Approved
AtazanavirThe metabolism of Sunitinib can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Sunitinib can be decreased when combined with Atomoxetine.Approved
AzithromycinSunitinib may increase the QTc-prolonging activities of Azithromycin.Approved
Bafilomycin A1The metabolism of Sunitinib can be decreased when combined with Bafilomycin A1.Experimental
BalaglitazoneBalaglitazone may increase the hypoglycemic activities of Sunitinib.Investigational
BalsalazideBalsalazide may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
BCG vaccineThe therapeutic efficacy of BCG vaccine can be decreased when used in combination with Sunitinib.Investigational
BedaquilineSunitinib may increase the QTc-prolonging activities of Bedaquiline.Approved
Bempedoic acidBempedoic acid may increase the hypoglycemic activities of Sunitinib.Investigational
BenmoxinBenmoxin may increase the hypoglycemic activities of Sunitinib.Withdrawn
Benzoic AcidThe metabolism of Sunitinib can be decreased when combined with Benzoic Acid.Approved
BevacizumabThe risk or severity of adverse effects can be increased when Sunitinib is combined with Bevacizumab.Approved, Investigational
BifonazoleThe metabolism of Sunitinib can be decreased when combined with Bifonazole.Approved, Investigational
BoceprevirThe metabolism of Sunitinib can be decreased when combined with Boceprevir.Approved, Withdrawn
BortezomibThe metabolism of Sunitinib can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Sunitinib can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Sunitinib.Approved
Brefeldin AThe metabolism of Sunitinib can be decreased when combined with Brefeldin A.Experimental
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Sunitinib.Approved
BrofaromineBrofaromine may increase the hypoglycemic activities of Sunitinib.Experimental
BuforminBuformin may increase the hypoglycemic activities of Sunitinib.Investigational, Withdrawn
ButenafineThe metabolism of Sunitinib can be decreased when combined with Butenafine.Approved
ButoconazoleThe metabolism of Sunitinib can be decreased when combined with Butoconazole.Approved
CabazitaxelThe risk or severity of adverse effects can be increased when Cabazitaxel is combined with Sunitinib.Approved
CanagliflozinCanagliflozin may increase the hypoglycemic activities of Sunitinib.Approved
CandicidinThe metabolism of Sunitinib can be decreased when combined with Candicidin.Withdrawn
Capric acidThe metabolism of Sunitinib can be decreased when combined with Capric acid.Experimental
CarbamazepineThe serum concentration of Sunitinib can be decreased when it is combined with Carbamazepine.Approved, Investigational
Carbaspirin calciumCarbaspirin calcium may increase the hypoglycemic activities of Sunitinib.Experimental, Investigational
CarbutamideCarbutamide may increase the hypoglycemic activities of Sunitinib.Experimental
CaroxazoneCaroxazone may increase the hypoglycemic activities of Sunitinib.Withdrawn
CaspofunginThe metabolism of Sunitinib can be decreased when combined with Caspofungin.Approved
CastanospermineCastanospermine may increase the hypoglycemic activities of Sunitinib.Experimental
CeritinibThe serum concentration of Sunitinib can be increased when it is combined with Ceritinib.Approved
CeruleninThe metabolism of Sunitinib can be decreased when combined with Cerulenin.Approved
ChloroquineSunitinib may increase the QTc-prolonging activities of Chloroquine.Approved, Vet Approved
ChloroxineThe metabolism of Sunitinib can be decreased when combined with Chloroxine.Approved
ChlorpromazineSunitinib may increase the QTc-prolonging activities of Chlorpromazine.Approved, Vet Approved
ChlorpropamideChlorpropamide may increase the hypoglycemic activities of Sunitinib.Approved
CiclopiroxThe metabolism of Sunitinib can be decreased when combined with Ciclopirox.Approved, Investigational
CiglitazoneCiglitazone may increase the hypoglycemic activities of Sunitinib.Experimental
CinoxacinCinoxacin may increase the hypoglycemic activities of Sunitinib.Approved, Investigational, Withdrawn
CiprofloxacinSunitinib may increase the QTc-prolonging activities of Ciprofloxacin.Approved, Investigational
CisaprideSunitinib may increase the QTc-prolonging activities of Cisapride.Approved, Investigational, Withdrawn
CitalopramSunitinib may increase the QTc-prolonging activities of Citalopram.Approved
ClarithromycinThe metabolism of Sunitinib can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Sunitinib can be decreased when combined with Clemastine.Approved
Clostridium tetani toxoid antigen (formaldehyde inactivated)The therapeutic efficacy of Clostridium tetani toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Sunitinib.Approved
ClotrimazoleThe metabolism of Sunitinib can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineSunitinib may increase the QTc-prolonging activities of Clozapine.Approved
CobicistatThe metabolism of Sunitinib can be decreased when combined with Cobicistat.Approved
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Sunitinib.Approved
ConivaptanThe serum concentration of Sunitinib can be increased when it is combined with Conivaptan.Approved, Investigational
CordycepinThe metabolism of Sunitinib can be decreased when combined with Cordycepin.Investigational
Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated)The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Sunitinib.Approved
CrizotinibSunitinib may increase the QTc-prolonging activities of Crizotinib.Approved
CyclophosphamideCyclophosphamide may increase the cardiotoxic activities of Sunitinib.Approved, Investigational
CyclosporineThe metabolism of Sunitinib can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
CymarinCymarin may decrease the cardiotoxic activities of Sunitinib.Experimental
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Sunitinib.Approved
DabrafenibThe serum concentration of Sunitinib can be decreased when it is combined with Dabrafenib.Approved
DapoxetineDapoxetine may increase the hypoglycemic activities of Sunitinib.Investigational
DarunavirThe metabolism of Sunitinib can be decreased when combined with Darunavir.Approved
DasatinibThe serum concentration of Sunitinib can be increased when it is combined with Dasatinib.Approved, Investigational
DeferasiroxThe serum concentration of Sunitinib can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Sunitinib can be decreased when combined with Delavirdine.Approved
DenosumabThe risk or severity of adverse effects can be increased when Denosumab is combined with Sunitinib.Approved
DeoxyspergualinDeoxyspergualin may increase the hypoglycemic activities of Sunitinib.Investigational
dersalazinedersalazine may increase the hypoglycemic activities of Sunitinib.Investigational
DeslanosideDeslanoside may decrease the cardiotoxic activities of Sunitinib.Approved
DesvenlafaxineDesvenlafaxine may increase the hypoglycemic activities of Sunitinib.Approved
DexamethasoneThe serum concentration of Sunitinib can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DichloropheneThe metabolism of Sunitinib can be decreased when combined with Dichlorophene.Vet Approved
DiflunisalDiflunisal may increase the hypoglycemic activities of Sunitinib.Approved
DigitoxinDigitoxin may decrease the cardiotoxic activities of Sunitinib.Approved, Investigational
DigoxinDigoxin may decrease the cardiotoxic activities of Sunitinib.Approved
Digoxin Immune Fab (Ovine)Digoxin Immune Fab (Ovine) may decrease the cardiotoxic activities of Sunitinib.Approved
DihydroergotamineThe metabolism of Sunitinib can be decreased when combined with Dihydroergotamine.Approved
DihydrotestosteroneDihydrotestosterone may increase the hypoglycemic activities of Sunitinib.Illicit
DiltiazemThe metabolism of Sunitinib can be decreased when combined with Diltiazem.Approved
DisopyramideSunitinib may increase the QTc-prolonging activities of Disopyramide.Approved
DocetaxelThe risk or severity of adverse effects can be increased when Docetaxel is combined with Sunitinib.Approved, Investigational
DofetilideSunitinib may increase the QTc-prolonging activities of Dofetilide.Approved
DolasetronSunitinib may increase the QTc-prolonging activities of Dolasetron.Approved
DomperidoneSunitinib may increase the QTc-prolonging activities of Domperidone.Approved, Investigational, Vet Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Sunitinib.Approved, Investigational
DoxycyclineThe metabolism of Sunitinib can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronedaroneSunitinib may increase the QTc-prolonging activities of Dronedarone.Approved
DroperidolSunitinib may increase the QTc-prolonging activities of Droperidol.Approved, Vet Approved
DulaglutideDulaglutide may increase the hypoglycemic activities of Sunitinib.Approved
DuloxetineDuloxetine may increase the hypoglycemic activities of Sunitinib.Approved
EconazoleThe metabolism of Sunitinib can be decreased when combined with Econazole.Approved
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Sunitinib.Approved
EfinaconazoleThe metabolism of Sunitinib can be decreased when combined with Efinaconazole.Approved
EliglustatSunitinib may increase the QTc-prolonging activities of Eliglustat.Approved
EmpagliflozinEmpagliflozin may increase the hypoglycemic activities of Sunitinib.Approved
EnoxacinEnoxacin may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
EnzalutamideThe serum concentration of Sunitinib can be decreased when it is combined with Enzalutamide.Approved
ErythromycinSunitinib may increase the QTc-prolonging activities of Erythromycin.Approved, Vet Approved
EscitalopramSunitinib may increase the QTc-prolonging activities of Escitalopram.Approved, Investigational
EtoperidoneEtoperidone may increase the hypoglycemic activities of Sunitinib.Withdrawn
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Sunitinib.Approved
ExenatideExenatide may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
FenticonazoleThe metabolism of Sunitinib can be decreased when combined with Fenticonazole.Experimental
FingolimodSunitinib may increase the immunosuppressive activities of Fingolimod.Approved, Investigational
FlecainideSunitinib may increase the QTc-prolonging activities of Flecainide.Approved, Withdrawn
FleroxacinFleroxacin may increase the hypoglycemic activities of Sunitinib.Approved
FluconazoleThe metabolism of Sunitinib can be decreased when combined with Fluconazole.Approved
FlucytosineThe metabolism of Sunitinib can be decreased when combined with Flucytosine.Approved
FlumequineFlumequine may increase the hypoglycemic activities of Sunitinib.Withdrawn
FluoxetineSunitinib may increase the QTc-prolonging activities of Fluoxetine.Approved, Vet Approved
FluoxymesteroneFluoxymesterone may increase the hypoglycemic activities of Sunitinib.Approved, Illicit
FlupentixolSunitinib may increase the QTc-prolonging activities of Flupentixol.Approved, Withdrawn
FlutrimazoleThe metabolism of Sunitinib can be decreased when combined with Flutrimazole.Experimental
FluvoxamineThe metabolism of Sunitinib can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Sunitinib can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Sunitinib can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Sunitinib can be decreased when it is combined with Fosphenytoin.Approved
FurazolidoneFurazolidone may increase the hypoglycemic activities of Sunitinib.Approved, Investigational, Vet Approved
Fusidic AcidThe serum concentration of Sunitinib can be increased when it is combined with Fusidic Acid.Approved
G17DTThe therapeutic efficacy of G17DT can be decreased when used in combination with Sunitinib.Investigational
Gadobenic acidSunitinib may increase the QTc-prolonging activities of Gadobenic acid.Approved
GarenoxacinGarenoxacin may increase the hypoglycemic activities of Sunitinib.Investigational
GatifloxacinGatifloxacin may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
GemifloxacinSunitinib may increase the QTc-prolonging activities of Gemifloxacin.Approved, Investigational
GI-5005The therapeutic efficacy of GI-5005 can be decreased when used in combination with Sunitinib.Investigational
GitoformateGitoformate may decrease the cardiotoxic activities of Sunitinib.Experimental
GlibornurideGlibornuride may increase the hypoglycemic activities of Sunitinib.Investigational, Withdrawn
GliclazideGliclazide may increase the hypoglycemic activities of Sunitinib.Approved
GlimepirideGlimepiride may increase the hypoglycemic activities of Sunitinib.Approved
GlipizideGlipizide may increase the hypoglycemic activities of Sunitinib.Approved
GliquidoneGliquidone may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
GLPG-0492GLPG-0492 may increase the hypoglycemic activities of Sunitinib.Investigational
GlyburideGlyburide may increase the hypoglycemic activities of Sunitinib.Approved
GlyphosateThe metabolism of Sunitinib can be decreased when combined with Glyphosate.Experimental
GoserelinSunitinib may increase the QTc-prolonging activities of Goserelin.Approved
GranisetronSunitinib may increase the QTc-prolonging activities of Granisetron.Approved, Investigational
GrepafloxacinGrepafloxacin may increase the hypoglycemic activities of Sunitinib.Investigational, Withdrawn
GriseofulvinThe metabolism of Sunitinib can be decreased when combined with Griseofulvin.Approved, Vet Approved
GuacetisalGuacetisal may increase the hypoglycemic activities of Sunitinib.Experimental
GusperimusGusperimus may increase the hypoglycemic activities of Sunitinib.Investigational
HachimycinThe metabolism of Sunitinib can be decreased when combined with Hachimycin.Experimental
HaloperidolSunitinib may increase the QTc-prolonging activities of Haloperidol.Approved
HaloproginThe metabolism of Sunitinib can be decreased when combined with Haloprogin.Approved, Withdrawn
HarmalineHarmaline may increase the hypoglycemic activities of Sunitinib.Experimental
Hemoglobin crosfumarilHemoglobin crosfumaril may increase the hypoglycemic activities of Sunitinib.Experimental
Hepatitis A VaccineThe therapeutic efficacy of Hepatitis A Vaccine can be decreased when used in combination with Sunitinib.Approved
Hepatitis B Vaccine (Recombinant)The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Sunitinib.Approved, Withdrawn
HexetidineThe metabolism of Sunitinib can be decreased when combined with Hexetidine.Approved, Investigational
HydracarbazineHydracarbazine may increase the hypoglycemic activities of Sunitinib.Experimental
IbutilideSunitinib may increase the QTc-prolonging activities of Ibutilide.Approved
IdelalisibThe serum concentration of Sunitinib can be increased when it is combined with Idelalisib.Approved
IloperidoneSunitinib may increase the QTc-prolonging activities of Iloperidone.Approved
ImatinibThe metabolism of Sunitinib can be decreased when combined with Imatinib.Approved
IndalpineIndalpine may increase the hypoglycemic activities of Sunitinib.Investigational, Withdrawn
IndinavirThe metabolism of Sunitinib can be decreased when combined with Indinavir.Approved
INGN 201The therapeutic efficacy of INGN 201 can be decreased when used in combination with Sunitinib.Investigational
INGN 225The therapeutic efficacy of INGN 225 can be decreased when used in combination with Sunitinib.Investigational
Insulin AspartSunitinib may increase the hypoglycemic activities of Insulin Aspart.Approved
Insulin DetemirSunitinib may increase the hypoglycemic activities of Insulin Detemir.Approved
Insulin GlargineInsulin Glargine may increase the hypoglycemic activities of Sunitinib.Approved
Insulin GlulisineSunitinib may increase the hypoglycemic activities of Insulin Glulisine.Approved
Insulin HumanInsulin Human may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
Insulin LisproInsulin Lispro may increase the hypoglycemic activities of Sunitinib.Approved
Insulin PorkInsulin Pork may increase the hypoglycemic activities of Sunitinib.Approved
IproclozideIproclozide may increase the hypoglycemic activities of Sunitinib.Withdrawn
IproniazidIproniazid may increase the hypoglycemic activities of Sunitinib.Withdrawn
IsavuconazoniumThe metabolism of Sunitinib can be decreased when combined with Isavuconazonium.Approved, Investigational
IsocarboxazidIsocarboxazid may increase the hypoglycemic activities of Sunitinib.Approved
IsoconazoleThe metabolism of Sunitinib can be decreased when combined with Isoconazole.Approved
IsradipineThe metabolism of Sunitinib can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Sunitinib can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Sunitinib can be increased when it is combined with Ivacaftor.Approved
KetoconazoleThe metabolism of Sunitinib can be decreased when combined with Ketoconazole.Approved, Investigational
Lanatoside CLanatoside C may decrease the cardiotoxic activities of Sunitinib.Experimental
LanreotideSunitinib may increase the hypoglycemic activities of Lanreotide.Approved
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Sunitinib.Approved
LeflunomideThe risk or severity of adverse effects can be increased when Sunitinib is combined with Leflunomide.Approved, Investigational
LenvatinibSunitinib may increase the QTc-prolonging activities of Lenvatinib.Approved
LeuprolideSunitinib may increase the QTc-prolonging activities of Leuprolide.Approved, Investigational
LevofloxacinSunitinib may increase the QTc-prolonging activities of Levofloxacin.Approved, Investigational
LevomilnacipranLevomilnacipran may increase the hypoglycemic activities of Sunitinib.Approved
LinagliptinLinagliptin may increase the hypoglycemic activities of Sunitinib.Approved
LiraglutideLiraglutide may increase the hypoglycemic activities of Sunitinib.Approved
LopinavirThe metabolism of Sunitinib can be decreased when combined with Lopinavir.Approved
LovastatinThe metabolism of Sunitinib can be decreased when combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Sunitinib can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Sunitinib can be decreased when it is combined with Lumacaftor.Approved
LumefantrineSunitinib may increase the QTc-prolonging activities of Lumefantrine.Approved
MebanazineMebanazine may increase the hypoglycemic activities of Sunitinib.Withdrawn
MecaserminSunitinib may increase the hypoglycemic activities of Mecasermin.Approved, Investigational
MepartricinThe metabolism of Sunitinib can be decreased when combined with Mepartricin.Experimental
MesalazineMesalazine may increase the hypoglycemic activities of Sunitinib.Approved
MesteroloneMesterolone may increase the hypoglycemic activities of Sunitinib.Experimental
MetforminMetformin may increase the hypoglycemic activities of Sunitinib.Approved
MethadoneSunitinib may increase the QTc-prolonging activities of Methadone.Approved
Methyl salicylateMethyl salicylate may increase the hypoglycemic activities of Sunitinib.Approved, Vet Approved
Methylene blueMethylene blue may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
MethyltestosteroneMethyltestosterone may increase the hypoglycemic activities of Sunitinib.Approved
MetildigoxinMetildigoxin may decrease the cardiotoxic activities of Sunitinib.Experimental
MevastatinThe metabolism of Sunitinib can be decreased when combined with Mevastatin.Experimental
MicafunginThe metabolism of Sunitinib can be decreased when combined with Micafungin.Approved, Investigational
MiconazoleThe metabolism of Sunitinib can be decreased when combined with Miconazole.Approved, Investigational, Vet Approved
MifepristoneMifepristone may increase the QTc-prolonging activities of Sunitinib.Approved, Investigational
MiglitolMiglitol may increase the hypoglycemic activities of Sunitinib.Approved
MiglustatMiglustat may increase the hypoglycemic activities of Sunitinib.Approved
MilnacipranMilnacipran may increase the hypoglycemic activities of Sunitinib.Approved
MiltefosineThe metabolism of Sunitinib can be decreased when combined with Miltefosine.Approved
MinaprineMinaprine may increase the hypoglycemic activities of Sunitinib.Approved
MitiglinideMitiglinide may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
MitotaneThe serum concentration of Sunitinib can be decreased when it is combined with Mitotane.Approved
MoclobemideMoclobemide may increase the hypoglycemic activities of Sunitinib.Approved
MonensinThe metabolism of Sunitinib can be decreased when combined with Monensin.Vet Approved
MoxifloxacinSunitinib may increase the QTc-prolonging activities of Moxifloxacin.Approved, Investigational
MyxothiazolThe metabolism of Sunitinib can be decreased when combined with Myxothiazol.Experimental
NaftifineThe metabolism of Sunitinib can be decreased when combined with Naftifine.Approved
Nalidixic AcidNalidixic Acid may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Sunitinib.Approved
NandroloneNandrolone may increase the hypoglycemic activities of Sunitinib.Experimental, Investigational
Nandrolone decanoateNandrolone decanoate may increase the hypoglycemic activities of Sunitinib.Approved, Illicit
NatalizumabThe risk or severity of adverse effects can be increased when Sunitinib is combined with Natalizumab.Approved, Investigational
NatamycinThe metabolism of Sunitinib can be decreased when combined with Natamycin.Approved
NateglinideNateglinide may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
NefazodoneThe metabolism of Sunitinib can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Sunitinib can be decreased when combined with Nelfinavir.Approved
NemonoxacinNemonoxacin may increase the hypoglycemic activities of Sunitinib.Investigational
NetupitantThe serum concentration of Sunitinib can be increased when it is combined with Netupitant.Approved
NevirapineThe serum concentration of Sunitinib can be decreased when it is combined with Nevirapine.Approved
NialamideNialamide may increase the hypoglycemic activities of Sunitinib.Withdrawn
NifuratelThe metabolism of Sunitinib can be decreased when combined with Nifuratel.Experimental
Nikkomycin ZThe metabolism of Sunitinib can be decreased when combined with Nikkomycin Z.Investigational
NilotinibSunitinib may increase the QTc-prolonging activities of Nilotinib.Approved, Investigational
NitroaspirinNitroaspirin may increase the hypoglycemic activities of Sunitinib.Investigational
NitroxolineThe metabolism of Sunitinib can be decreased when combined with Nitroxoline.Approved
NorfloxacinNorfloxacin may increase the hypoglycemic activities of Sunitinib.Approved
NystatinThe metabolism of Sunitinib can be decreased when combined with Nystatin.Approved, Vet Approved
OctamoxinOctamoxin may increase the hypoglycemic activities of Sunitinib.Withdrawn
OctreotideOctreotide may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
OfloxacinSunitinib may increase the QTc-prolonging activities of Ofloxacin.Approved
OlaparibThe metabolism of Sunitinib can be decreased when combined with Olaparib.Approved
OleandrinOleandrin may decrease the cardiotoxic activities of Sunitinib.Experimental, Investigational
OlsalazineOlsalazine may increase the hypoglycemic activities of Sunitinib.Approved
OmoconazoleThe metabolism of Sunitinib can be decreased when combined with Omoconazole.Experimental
OndansetronSunitinib may increase the QTc-prolonging activities of Ondansetron.Approved
OsimertinibThe serum concentration of Sunitinib can be increased when it is combined with Osimertinib.Approved
OuabainOuabain may decrease the cardiotoxic activities of Sunitinib.Approved
OxandroloneOxandrolone may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
OxiconazoleThe metabolism of Sunitinib can be decreased when combined with Oxiconazole.Approved
Oxolinic acidOxolinic acid may increase the hypoglycemic activities of Sunitinib.Experimental
OxymetholoneOxymetholone may increase the hypoglycemic activities of Sunitinib.Approved, Illicit
PaclitaxelThe risk or severity of adverse effects can be increased when Paclitaxel is combined with Sunitinib.Approved, Vet Approved
pafuramidineThe metabolism of Sunitinib can be decreased when combined with pafuramidine.Investigational
PalbociclibThe serum concentration of Sunitinib can be increased when it is combined with Palbociclib.Approved
PaliperidoneSunitinib may increase the QTc-prolonging activities of Paliperidone.Approved
PanobinostatSunitinib may increase the QTc-prolonging activities of Panobinostat.Approved, Investigational
PargylinePargyline may increase the hypoglycemic activities of Sunitinib.Approved
ParoxetineParoxetine may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
PasireotideSunitinib may increase the hypoglycemic activities of Pasireotide.Approved
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Sunitinib.Approved
PazufloxacinPazufloxacin may increase the hypoglycemic activities of Sunitinib.Investigational
PefloxacinPefloxacin may increase the hypoglycemic activities of Sunitinib.Approved
PegvisomantPegvisomant may increase the hypoglycemic activities of Sunitinib.Approved
PentamidineThe metabolism of Sunitinib can be decreased when combined with Pentamidine.Approved
PentobarbitalThe serum concentration of Sunitinib can be decreased when it is combined with Pentobarbital.Approved, Vet Approved
PerflutrenSunitinib may increase the QTc-prolonging activities of Perflutren.Approved
PeruvosidePeruvoside may decrease the cardiotoxic activities of Sunitinib.Experimental
PhenelzinePhenelzine may increase the hypoglycemic activities of Sunitinib.Approved
PhenforminPhenformin may increase the hypoglycemic activities of Sunitinib.Approved, Investigational, Withdrawn
PheniprazinePheniprazine may increase the hypoglycemic activities of Sunitinib.Withdrawn
PhenobarbitalThe serum concentration of Sunitinib can be decreased when it is combined with Phenobarbital.Approved
PhenoxypropazinePhenoxypropazine may increase the hypoglycemic activities of Sunitinib.Withdrawn
PhenytoinThe serum concentration of Sunitinib can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PimecrolimusThe risk or severity of adverse effects can be increased when Pimecrolimus is combined with Sunitinib.Approved, Investigational
PimozideSunitinib may increase the QTc-prolonging activities of Pimozide.Approved
PioglitazonePioglitazone may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
Pipemidic acidPipemidic acid may increase the hypoglycemic activities of Sunitinib.Experimental
PirlindolePirlindole may increase the hypoglycemic activities of Sunitinib.Approved
Piromidic acidPiromidic acid may increase the hypoglycemic activities of Sunitinib.Experimental
PivhydrazinePivhydrazine may increase the hypoglycemic activities of Sunitinib.Withdrawn
PosaconazoleThe metabolism of Sunitinib can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PramlintidePramlintide may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
PrimaquineSunitinib may increase the QTc-prolonging activities of Primaquine.Approved
PrimidoneThe serum concentration of Sunitinib can be decreased when it is combined with Primidone.Approved, Vet Approved
ProcainamideSunitinib may increase the QTc-prolonging activities of Procainamide.Approved
ProcarbazineProcarbazine may increase the hypoglycemic activities of Sunitinib.Approved
PromazineSunitinib may increase the QTc-prolonging activities of Promazine.Approved, Vet Approved
PropafenoneSunitinib may increase the QTc-prolonging activities of Propafenone.Approved
ProscillaridinProscillaridin may decrease the cardiotoxic activities of Sunitinib.Experimental
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Sunitinib.Approved
PrulifloxacinPrulifloxacin may increase the hypoglycemic activities of Sunitinib.Investigational
PyrrolnitrinThe metabolism of Sunitinib can be decreased when combined with Pyrrolnitrin.Experimental
QuetiapineSunitinib may increase the QTc-prolonging activities of Quetiapine.Approved
QuinidineSunitinib may increase the QTc-prolonging activities of Quinidine.Approved
QuinineSunitinib may increase the QTc-prolonging activities of Quinine.Approved
Rabies virus inactivated antigen, AThe risk or severity of adverse effects can be increased when Sunitinib is combined with Rabies virus inactivated antigen, A.Approved
Rabies virus inactivated antigen, AThe therapeutic efficacy of Rabies virus inactivated antigen, A can be decreased when used in combination with Sunitinib.Approved
RadicicolThe metabolism of Sunitinib can be decreased when combined with Radicicol.Experimental
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Sunitinib.Approved, Investigational
RasagilineRasagiline may increase the hypoglycemic activities of Sunitinib.Approved
RepaglinideRepaglinide may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
RifabutinThe serum concentration of Sunitinib can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Sunitinib can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Sunitinib can be decreased when it is combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Sunitinib.Approved, Investigational
RindopepimutThe therapeutic efficacy of Rindopepimut can be decreased when used in combination with Sunitinib.Investigational
RoflumilastRoflumilast may increase the immunosuppressive activities of Sunitinib.Approved
RosiglitazoneRosiglitazone may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
RosoxacinRosoxacin may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
Rotavirus VaccineThe therapeutic efficacy of Rotavirus Vaccine can be decreased when used in combination with Sunitinib.Approved
Rubella virus vaccineThe therapeutic efficacy of Rubella virus vaccine can be decreased when used in combination with Sunitinib.Approved
RufloxacinRufloxacin may increase the hypoglycemic activities of Sunitinib.Experimental
SafrazineSafrazine may increase the hypoglycemic activities of Sunitinib.Withdrawn
Salicylhydroxamic AcidThe metabolism of Sunitinib can be decreased when combined with Salicylhydroxamic Acid.Experimental
Salicylic acidThe metabolism of Sunitinib can be decreased when combined with Salicylic acid.Approved, Vet Approved
Salmonella typhi ty21a live antigenThe therapeutic efficacy of Salmonella typhi ty21a live antigen can be decreased when used in combination with Sunitinib.Approved
SaquinavirThe metabolism of Sunitinib can be decreased when combined with Saquinavir.Approved, Investigational
SaxagliptinSaxagliptin may increase the hypoglycemic activities of Sunitinib.Approved
SelegilineSelegiline may increase the hypoglycemic activities of Sunitinib.Approved, Investigational, Vet Approved
SertaconazoleThe metabolism of Sunitinib can be decreased when combined with Sertaconazole.Approved
SertralineSertraline may increase the hypoglycemic activities of Sunitinib.Approved
SildenafilThe metabolism of Sunitinib can be decreased when combined with Sildenafil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Sunitinib.Approved
SiltuximabThe serum concentration of Sunitinib can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Sunitinib can be increased when it is combined with Simeprevir.Approved
SinefunginThe metabolism of Sunitinib can be decreased when combined with Sinefungin.Experimental
Sipuleucel-TThe therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Sunitinib.Approved
SirolimusThe metabolism of Sunitinib can be decreased when combined with Sirolimus.Approved, Investigational
SitafloxacinSitafloxacin may increase the hypoglycemic activities of Sunitinib.Experimental, Investigational
SitagliptinSitagliptin may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
SotagliflozinSotagliflozin may increase the hypoglycemic activities of Sunitinib.Investigational
SotalolSunitinib may increase the QTc-prolonging activities of Sotalol.Approved
SparfloxacinSparfloxacin may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
SRP 299The therapeutic efficacy of SRP 299 can be decreased when used in combination with Sunitinib.Investigational
St. John's WortThe serum concentration of Sunitinib can be decreased when it is combined with St. John's Wort.Investigational, Nutraceutical
StanozololStanozolol may increase the hypoglycemic activities of Sunitinib.Approved, Vet Approved
StiripentolThe serum concentration of Sunitinib can be increased when it is combined with Stiripentol.Approved
SulconazoleThe metabolism of Sunitinib can be decreased when combined with Sulconazole.Approved
SulfadiazineSulfadiazine may increase the hypoglycemic activities of Sunitinib.Approved, Vet Approved
SulfamethoxazoleSulfamethoxazole may increase the hypoglycemic activities of Sunitinib.Approved
SulfisoxazoleSunitinib may increase the QTc-prolonging activities of Sulfisoxazole.Approved, Vet Approved
SulodexideSulodexide may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
TacrolimusThe risk or severity of adverse effects can be increased when Tacrolimus is combined with Sunitinib.Approved, Investigational
TavaboroleThe metabolism of Sunitinib can be decreased when combined with Tavaborole.Approved
TecemotideThe therapeutic efficacy of Tecemotide can be decreased when used in combination with Sunitinib.Investigational
TelaprevirThe metabolism of Sunitinib can be decreased when combined with Telaprevir.Approved, Withdrawn
TelavancinSunitinib may increase the QTc-prolonging activities of Telavancin.Approved
TelithromycinThe metabolism of Sunitinib can be decreased when combined with Telithromycin.Approved
TemafloxacinTemafloxacin may increase the hypoglycemic activities of Sunitinib.Withdrawn
TemsirolimusThe risk or severity of adverse effects can be increased when Temsirolimus is combined with Sunitinib.Approved
TerbinafineThe metabolism of Sunitinib can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TerconazoleThe metabolism of Sunitinib can be decreased when combined with Terconazole.Approved
TestosteroneTestosterone may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
Testosterone PropionateTestosterone Propionate may increase the hypoglycemic activities of Sunitinib.Approved, Vet Approved
TetrabenazineSunitinib may increase the QTc-prolonging activities of Tetrabenazine.Approved
TG4010The therapeutic efficacy of TG4010 can be decreased when used in combination with Sunitinib.Investigational
ThioridazineSunitinib may increase the QTc-prolonging activities of Thioridazine.Approved, Withdrawn
ThymolThe metabolism of Sunitinib can be decreased when combined with Thymol.Approved
TiclopidineThe metabolism of Sunitinib can be decreased when combined with Ticlopidine.Approved
TioconazoleThe metabolism of Sunitinib can be decreased when combined with Tioconazole.Approved
TocilizumabThe serum concentration of Sunitinib can be decreased when it is combined with Tocilizumab.Approved
TofacitinibSunitinib may increase the immunosuppressive activities of Tofacitinib.Approved, Investigational
TolazamideTolazamide may increase the hypoglycemic activities of Sunitinib.Approved
TolbutamideTolbutamide may increase the hypoglycemic activities of Sunitinib.Approved
TolciclateThe metabolism of Sunitinib can be decreased when combined with Tolciclate.Experimental
TolnaftateThe metabolism of Sunitinib can be decreased when combined with Tolnaftate.Approved, Vet Approved
ToloxatoneToloxatone may increase the hypoglycemic activities of Sunitinib.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Sunitinib.Approved, Investigational
ToremifeneSunitinib may increase the QTc-prolonging activities of Toremifene.Approved, Investigational
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypoglycemic activities of Sunitinib.Experimental
TranylcypromineTranylcypromine may increase the hypoglycemic activities of Sunitinib.Approved
TrastuzumabTrastuzumab may increase the cardiotoxic activities of Sunitinib.Approved, Investigational
TrimetrexateThe metabolism of Sunitinib can be decreased when combined with Trimetrexate.Approved, Investigational
TroglitazoneTroglitazone may increase the hypoglycemic activities of Sunitinib.Investigational, Withdrawn
Trolamine salicylateTrolamine salicylate may increase the hypoglycemic activities of Sunitinib.Approved
TrovafloxacinTrovafloxacin may increase the hypoglycemic activities of Sunitinib.Approved, Investigational, Withdrawn
VandetanibSunitinib may increase the QTc-prolonging activities of Vandetanib.Approved
VemurafenibSunitinib may increase the QTc-prolonging activities of Vemurafenib.Approved
VenlafaxineThe metabolism of Sunitinib can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Sunitinib can be decreased when combined with Verapamil.Approved
VildagliptinVildagliptin may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
VincristineThe serum concentration of Vincristine can be increased when it is combined with Sunitinib.Approved, Investigational
VogliboseVoglibose may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
VoriconazoleThe metabolism of Sunitinib can be decreased when combined with Voriconazole.Approved, Investigational
Yellow fever vaccineThe therapeutic efficacy of Yellow fever vaccine can be decreased when used in combination with Sunitinib.Approved
ZimelidineZimelidine may increase the hypoglycemic activities of Sunitinib.Withdrawn
ZiprasidoneSunitinib may increase the QTc-prolonging activities of Ziprasidone.Approved
Zoster vaccineThe therapeutic efficacy of Zoster vaccine can be decreased when used in combination with Sunitinib.Approved
ZuclopenthixolSunitinib may increase the QTc-prolonging activities of Zuclopenthixol.Approved, Investigational
Food Interactions
Not Available

References

Synthesis Reference

Ettore BIGATTI, Augusto CANAVESI, Peter Lindsay MACDONALD, Francesca Scarpitta, "PROCESSES FOR PREPARING SUNITINIB AND SALTS THEREOF." U.S. Patent US20090247767, issued October 01, 2009.

US20090247767
General References
  1. Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O, Oudard S, Negrier S, Szczylik C, Kim ST, Chen I, Bycott PW, Baum CM, Figlin RA: Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 2007 Jan 11;356(2):115-24. [PubMed:17215529]
  2. Demetri GD, van Oosterom AT, Garrett CR, Blackstein ME, Shah MH, Verweij J, McArthur G, Judson IR, Heinrich MC, Morgan JA, Desai J, Fletcher CD, George S, Bello CL, Huang X, Baum CM, Casali PG: Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet. 2006 Oct 14;368(9544):1329-38. [PubMed:17046465]
External Links
Human Metabolome Database
HMDB15397
KEGG Drug
D06402
PubChem Compound
5329102
PubChem Substance
46507140
ChemSpider
4486264
BindingDB
4814
ChEBI
38940
ChEMBL
CHEMBL535
Therapeutic Targets Database
DCL000646
PharmGKB
PA162372840
HET
B49
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Sunitinib
ATC Codes
L01XE04 — Sunitinib
AHFS Codes
  • 10:00.00 — Antineoplastic Agents
PDB Entries
2y7j / 3g0e / 3g0f / 3miy / 3ti1 / 4agd / 4ks8 / 4qmz
FDA label
Download (159 KB)
MSDS
Download (98.3 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedTreatmentGlioblastomas / Neoplasms, Brain1
0CompletedTreatmentTumors, Solid1
1Active Not RecruitingTreatmentAdult Solid Neoplasm1
1Active Not RecruitingTreatmentCancer, Advanced1
1Active Not RecruitingTreatmentClear-cell Metastatic Renal Cell Carcinoma / Renal Cell Adenocarcinoma1
1Active Not RecruitingTreatmentGastrointestinal Stromal Tumors1
1Active Not RecruitingTreatmentMetastatic Brain Tumors1
1Active Not RecruitingTreatmentMetastatic Melanoma1
1Active Not RecruitingTreatmentNon GIST Sarcomas1
1CompletedNot AvailableHealthy Volunteers1
1CompletedBasic ScienceBlood Pressures1
1CompletedDiagnosticRenal Cell Adenocarcinoma1
1CompletedTreatmentAccelerated Phase Chronic Myelogenous Leukemia / Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome / Acute Undifferentiated Leukemia (AUL) / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Grade III Lymphomatoid Granulomatosis / Adult Langerhans Cell Histiocytosis / Adult Nasal Type Extranodal NK/T-Cell Lymphoma / Aggressive NK-cell Leukemia / AIDS-Related Diffuse Large Cell Lymphoma / AIDS-Related Diffuse Mixed Cell Lymphoma / AIDS-Related Diffuse Small Cleaved Cell Lymphoma / AIDS-related Immunoblastic Large Cell Lymphoma / AIDS-Related Lymphoblastic Lymphoma / Aids-related Malignancies / AIDS-related Small Noncleaved Cell Lymphoma / Anaplastic Large Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative / Chronic Eosinophilic Leukemia (CEL) / Chronic Myelomonocytic Leukemia / Chronic Neutrophilic Leukemia / Chronic Phase Chronic Myelogenous Leukemia / Clear Cell Renal Cell Carcinoma / Cutaneous B-Cell Non-Hodgkin Lymphoma / De Novo Myelodysplastic Syndromes / Essential Thrombocythemia (ET) / Extramedullary Plasmacytoma / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Hepatosplenic T-Cell Lymphoma / HIV-associated Hodgkin Lymphoma / Human Immunodeficiency Virus (HIV) Infections / Intraocular Lymphoma / Isolated Plasmacytoma of Bone / Leukemia, Prolymphocytic / Light Chain Deposition Disease / Malignant mast cell neoplasm / Myelodysplastic Syndrome With Isolated Del(5q) / Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable / Myeloid/NK-cell Acute Leukemia / Nodal marginal zone B-cell lymphomas / Noncutaneous Extranodal Lymphoma / Osteolytic Lesions of Multiple Myeloma / Peripheral T-Cell Lymphoma (PTCL) / Plasma Cell Neoplasms / Polycythemia Vera (PV) / Post-Transplant Lymphoproliferative Disorder / Previously Treated Myelodysplastic Syndromes / Primary Myelofibrosis / Primary Systemic Amyloidosis / Progressive Hairy Cell Leukemia, Initial Treatment / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Renal Cell Cancer / Recurrent Small Lymphocytic Lymphoma / Refractory Chronic Lymphocytic Leukemia / Refractory Hairy Cell Leukemia / Refractory Multiple Myeloma / Relapsing Chronic Myelogenous Leukemia / Stage IV Renal Cell Cancer / T-Cell Large Granular Lymphocyte Leukemia / Testicular Lymphoma / Unspecified Adult Solid Tumor, Protocol Specific / Waldenstrom's Macroglobulinemia (WM)1
1CompletedTreatmentAdenocarcinoma of the Pancreas / Recurrent Pancreatic Cancer / Stage III Pancreatic Cancer / Stage IV Pancreatic Cancer / Unspecified Adult Solid Tumor, Protocol Specific1
1CompletedTreatmentAdult Solid Neoplasm / Clear Cell Renal Cell Carcinoma / Renal Cell Carcinoma Recurrent / Stage III Renal Cell Cancer / Stage IV Renal Cell Cancer1
1CompletedTreatmentAdvanced Solid Tumors1
1CompletedTreatmentAdvanced Solid Tumors / Lung Cancer Non-Small Cell Cancer (NSCLC)1
1CompletedTreatmentCancer, Breast1
1CompletedTreatmentCancer, Breast / Neoplasms / Tumors, Solid1
1CompletedTreatmentCancers2
1CompletedTreatmentCancers / Head and Neck Carcinoma / Nervous System Neoplasms / Pelvic Cancer / Thoracic Neoplasms1
1CompletedTreatmentCentral Nervous System Metastases / Childhood Central Nervous System Choriocarcinoma / Childhood Central Nervous System Embryonal Tumor / Childhood Central Nervous System Germ Cell Tumor / Childhood Central Nervous System Germinoma / Childhood Central Nervous System Mixed Germ Cell Tumor / Childhood Central Nervous System Teratoma / Childhood Central Nervous System Yolk Sac Tumor / Recurrent Childhood Central Nervous System Embryonal Tumor / Unspecified Childhood Solid Tumor, Protocol Specific1
1CompletedTreatmentClear Cell Renal Cell Carcinoma / Recurrent Renal Cell Cancer / Stage I Renal Cell Cancer / Stage II Renal Cell Cancer / Stage III Renal Cell Cancer / Stage IV Renal Cell Cancer / Unspecified Adult Solid Tumor, Protocol Specific1
1CompletedTreatmentClear Cell Sarcoma of the Kidney / Renal Cell Carcinoma Recurrent / Stage III Renal Cell Cancer / Stage IV Renal Cell Cancer1
1CompletedTreatmentGIST / Renal Cancers1
1CompletedTreatmentGlioblastomas1
1CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)2
1CompletedTreatmentMetastatic Renal Cell Cancer1
1CompletedTreatmentMetastatic Renal Cell Carcinoma / Renal Cancers1
1CompletedTreatmentNeoplasms2
1CompletedTreatmentNeoplasms, Breast2
1CompletedTreatmentNeoplasms, Colorectal1
1CompletedTreatmentNeoplasms, Malignant1
1CompletedTreatmentNeoplasms / Neoplasms, Colorectal1
1CompletedTreatmentProstate Cancer2
1CompletedTreatmentRenal Cancers / Renal Cell Adenocarcinoma2
1CompletedTreatmentRenal Cell Adenocarcinoma2
1CompletedTreatmentSoft Tissue Sarcoma (STS)1
1CompletedTreatmentStomach Neoplasms3
1CompletedTreatmentTumors, Solid3
1CompletedTreatmentUnspecified Adult Solid Tumor, Protocol Specific2
1RecruitingTreatmentProstatic Neoplasms1
1RecruitingTreatmentTumors, Solid1
1RecruitingTreatmentUntreated Adult Acute Myeloid Leukemia1
1SuspendedTreatmentAnaplastic Gliomas / Gliosarcoma / Recurrent Glioblastoma1
1TerminatedTreatmentAdvanced Solid Tumors / Cancer, Advanced1
1TerminatedTreatmentCancer, Breast1
1TerminatedTreatmentEsophageal Cancers / Malignant Neoplasm of Stomach1
1TerminatedTreatmentGastrointestinal Stromal Tumors1
1TerminatedTreatmentMetastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma / Recurrent Metastatic Squamous Neck Cancer With Occult Primary / Recurrent Salivary Gland Cancer / Recurrent Squamous Cell Carcinoma of the Hypopharynx / Recurrent Squamous Cell Carcinoma of the Larynx / Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity / Recurrent Squamous Cell Carcinoma of the Nasopharynx / Recurrent Squamous Cell Carcinoma of the Oropharynx / Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Recurrent Verrucous Carcinoma of the Larynx / Recurrent Verrucous Carcinoma of the Oral Cavity / Salivary Gland Squamous Cell Carcinoma / Stage III Salivary Gland Cancer / Stage III Squamous Cell Carcinoma of the Hypopharynx / Stage III Squamous Cell Carcinoma of the Larynx / Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage III Squamous Cell Carcinoma of the Nasopharynx / Stage III Squamous Cell Carcinoma of the Oropharynx / Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage III Verrucous Carcinoma of the Larynx / Stage III Verrucous Carcinoma of the Oral Cavity / Stage IV Salivary Gland Cancer / Stage IV Squamous Cell Carcinoma of the Hypopharynx / Stage IV Squamous Cell Carcinoma of the Larynx / Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IV Squamous Cell Carcinoma of the Nasopharynx / Stage IV Squamous Cell Carcinoma of the Oropharynx / Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage IV Verrucous Carcinoma of the Larynx / Stage IV Verrucous Carcinoma of the Oral Cavity / Tongue Cancer / Untreated Metastatic Squamous Neck Cancer With Occult Primary1
1TerminatedTreatmentRenal Cancers1
1TerminatedTreatmentTumors1
1Unknown StatusTreatmentMalignant Solid Tumours1
1, 2Active Not RecruitingTreatmentExtensive Stage Small Cell Lung Cancer / Recurrent Small Cell Lung Cancer1
1, 2CompletedTreatmentCancer, Breast3
1, 2CompletedTreatmentGastrointestinal Stromal Tumors1
1, 2CompletedTreatmentLeukemia Acute Myeloid Leukemia (AML)1
1, 2CompletedTreatmentProstatic Neoplasms1
1, 2CompletedTreatmentRenal Cell Adenocarcinoma1
1, 2Not Yet RecruitingTreatmentEbola Virus Disease1
1, 2RecruitingTreatmentAdvanced Renal Cell Carcinoma / Renal Cancers / Renal Cell Adenocarcinoma1
1, 2RecruitingTreatmentCancers1
1, 2RecruitingTreatmentGastrointestinal Stromal Tumors1
1, 2RecruitingTreatmentNeovascular Age-Related Macular Degeneration1
1, 2RecruitingTreatmentRenal Cell Adenocarcinoma1
1, 2RecruitingTreatmentSarcoma, Bone / Soft Tissue Sarcoma (STS)1
1, 2TerminatedTreatmentAdenocarcinoma of the Prostate / Prostate Cancer / Recurrent Prostate Cancer / Stage I Prostate Cancer / Stage III Prostate Cancer / Stage IV Prostate Cancer1
1, 2TerminatedTreatmentCarcinoma, Colorectal1
1, 2TerminatedTreatmentClear-cell Metastatic Renal Cell Carcinoma / Genitourinary tract neoplasm / Kidney Diseases / Neoplasms / Neoplasms by Histologic Type / Neoplasms, Kidney / Renal Cell Adenocarcinoma / Urologic Diseases / Urologic Neoplasms1
1, 2TerminatedTreatmentMelanoma1
1, 2TerminatedTreatmentMetastatic Breast Cancer (MBC)1
1, 2TerminatedTreatmentMetastatic Malignant Melanoma1
1, 2TerminatedTreatmentNeoplasms, Breast1
1, 2TerminatedTreatmentRenal Cell Adenocarcinoma3
1, 2TerminatedTreatmentVon Hippel-Lindau Syndrome1
1, 2Unknown StatusTreatmentCancer, Breast1
1, 2Unknown StatusTreatmentCancers1
1, 2Unknown StatusTreatmentSoft Tissue Sarcoma (STS)1
1, 2Unknown StatusTreatmentUrinary Bladder Neoplasms1
2Active Not RecruitingTreatmentAdvanced Rare Tumours1
2Active Not RecruitingTreatmentAdvanced Renal Cell Carcinoma1
2Active Not RecruitingTreatmentCarcinoid Tumors1
2Active Not RecruitingTreatmentClear Cell Renal Cell Carcinoma / Metastatic Renal Cell Cancer / Stage III Renal Cell Cancer / Stage IV Renal Cell Cancer1
2Active Not RecruitingTreatmentClear Cell, Metastatic Renal Cell Carcinoma1
2Active Not RecruitingTreatmentEndometrial Adenocarcinomas / Endometrial Endometrioid Adenocarcinoma / Endometrial Serous Adenocarcinoma / Recurrent Uterine Corpus Carcinoma / Stage IVA Uterine Corpus Cancer / Stage IVB Uterine Corpus Cancer / Uterine Carcinosarcoma / Uterine Corpus Carcinosarcoma1
2Active Not RecruitingTreatmentEsophageal Cancers1
2Active Not RecruitingTreatmentGenitourinary Cancers / Renal Cancers1
2Active Not RecruitingTreatmentInflammatory carcinoma of the breast / Male Breast Cancer / Stage II Breast Cancer / Stage IIIA Breast Cancer / Stage IIIB Breast Cancer / Stage IIIC Breast Cancer1
2Active Not RecruitingTreatmentLung Cancers1
2Active Not RecruitingTreatmentMetastatic Cancers1
2Active Not RecruitingTreatmentMetastatic Clear Cell Renal Cell Carcinoma1
2Active Not RecruitingTreatmentMetastatic Renal Cell Carcinoma2
2Active Not RecruitingTreatmentMetastatic Uveal Melanoma1
2Active Not RecruitingTreatmentOvarian Clear Cell Adenocarcinoma / Recurrent Ovarian Carcinoma1
2Active Not RecruitingTreatmentProstate Cancer2
2Active Not RecruitingTreatmentRecurrent Non-small Cell Lung Cancer / Recurrent Non-Small Cell Lung Carcinoma / Stage IIIb Non-small Cell Lung Cancer / Stage IIIB Non-Small Cell Lung Cancer AJCC v7 / Stage IV Non-Small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer AJCC v71
2Active Not RecruitingTreatmentRecurrent Thyroid Gland Carcinoma / Stage III Thyroid Gland Follicular Carcinoma / Stage III Thyroid Gland Medullary Carcinoma / Stage IV Thyroid Gland Follicular Carcinoma / Stage IV Thyroid Gland Medullary Carcinoma / Stage IV Thyroid Gland Papillary Carcinoma / Stage IVA Thyroid Gland Follicular Carcinoma / Stage IVA Thyroid Gland Medullary Carcinoma / Stage IVA Thyroid Gland Papillary Carcinoma / Stage IVB Thyroid Gland Follicular Carcinoma / Stage IVB Thyroid Gland Medullary Carcinoma / Stage IVB Thyroid Gland Papillary Carcinoma / Stage IVC Thyroid Gland Follicular Carcinoma / Stage IVC Thyroid Gland Medullary Carcinoma / Stage IVC Thyroid Gland Papillary Carcinoma / Thyroid Gland Oncocytic Follicular Carcinoma1
2Active Not RecruitingTreatmentRenal Cancers1
2Active Not RecruitingTreatmentRenal Cell Adenocarcinoma4
2Active Not RecruitingTreatmentRenal Cell Carcinoma Recurrent / Stage III Renal Cell Cancer / Stage IV Renal Cell Cancer1
2Active Not RecruitingTreatmentThymic Carcinoma1
2Active Not RecruitingTreatmentAdvanced thymic carcinoma / Thymus Neoplasms1
2Active Not RecruitingTreatmentUrinary Tract Urothelial Carcinoma1
2CompletedTreatmentAcinar Cell Adenocarcinoma of the Pancreas / Duct Cell Adenocarcinoma of the Pancreas / Recurrent Pancreatic Cancer / Stage IV Pancreatic Cancer1
2CompletedTreatmentAcral Lentiginous Malignant Melanoma / Mucosal Lentiginous Melanoma1
2CompletedTreatmentAdenocarcinoma of the Cervix / Cervical Adenosquamous Cell Carcinoma / Cervical Squamous Cell Carcinoma / Recurrent Cervical Cancer / Stage IVB Cervical Cancer1
2CompletedTreatmentAdenocarcinomas1
2CompletedTreatmentAdenocarcinomas of the Gastroesophageal Junction / Esophageal Cancers1
2CompletedTreatmentAdenocarcinomas / Lung Cancers1
2CompletedTreatmentAdult Anaplastic Astrocytoma / Adult Diffuse Astrocytoma / Adult Giant Cell Glioblastoma / Adult Glioblastoma / Adult Gliosarcoma / Adult Mixed Glioma / Adult Oligodendroglioma / Adult Pineal Gland Astrocytoma1
2CompletedTreatmentAdult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Stage IV Adult Diffuse Large Cell Lymphoma1
2CompletedTreatmentAdult Malignant Fibrous Histiocytoma of Bone / Cancer, Ovarian / Desmoid Tumors / Endometrial Cancers / Sarcomas / Small Intestine Cancer1
2CompletedTreatmentAdvanced Biliary Tract Adenocarcinoma1
2CompletedTreatmentAdvanced Gastric Cancer1
2CompletedTreatmentAdvanced Malignant Mesothelioma / Recurrent Malignant Mesothelioma1
2CompletedTreatmentAdvanced Non-clear Cell Renal Cell Carcinoma1
2CompletedTreatmentAdvanced/Metastatic Breast Cancer1
2CompletedTreatmentAnaplastic Astrocytoma (AA) / Glioblastomas1
2CompletedTreatmentB-Cell Chronic Lymphocytic Leukemia / Recurrent Small Lymphocytic Lymphoma / Refractory Chronic Lymphocytic Leukemia1
2CompletedTreatmentBladder Cancers1
2CompletedTreatmentBladder Cancers / Transitional Cell Cancer of the Renal Pelvis and Ureter1
2CompletedTreatmentBladder Cancers / Transitional Cell Cancer of the Renal Pelvis and Ureter / Urethral Cancer1
2CompletedTreatmentBladder Cancers / Urinary Bladder1
2CompletedTreatmentCancer of the Fallopian Tube / Platinum Refractory Epithelial Ovarian Cancer / Primary Cancer of the Peritoneum1
2CompletedTreatmentCancer, Breast2
2CompletedTreatmentCancer, Ovarian / Extragonadal Germ Cell Tumor / Teratoma / Testicular germ cell tumour1
2CompletedTreatmentCancer, Ovarian / Fallopian Tube Cancer / Malignant Peritoneal Neoplasm1
2CompletedTreatmentCancers / Renal Cell Adenocarcinoma1
2CompletedTreatmentCancers / Thyroid Carcinoma1
2CompletedTreatmentCarcinoma Renal Cells1
2CompletedTreatmentCarcinoma, Adenoid Cystic / Salivary Gland Cancers1
2CompletedTreatmentCarcinoma, Renal Cell Metastasis1
2CompletedTreatmentChildhood Cerebellar Anaplastic Astrocytoma / Childhood Cerebral Anaplastic Astrocytoma / Childhood Cerebral Astrocytoma / Childhood Infratentorial Ependymoma / Childhood Mixed Glioma / Childhood Oligodendroglioma / Childhood Supratentorial Ependymoma / Recurrent Childhood Cerebellar Astrocytoma / Recurrent Childhood Cerebral Astrocytoma / Recurrent Childhood Ependymoma / Recurrent Childhood Subependymal Giant Cell Astrocytoma1
2CompletedTreatmentChronic Myelomonocytic Leukemia / De Novo Myelodysplastic Syndromes / Myelodysplastic Syndromes / Secondary Myelodysplastic Syndromes1
2CompletedTreatmentClear Cell Renal Cell Carcinoma / Stage IV Renal Cell Cancer1
2CompletedTreatmentCns Cancer / Hemangioblastomas / Intracranial Hemangiopericytoma / Meningiomas / Neurofibromatosis1
2CompletedTreatmentDifferentiated Thyroid Cancer (DTC) / Follicular Thyroid Cancer / Thyroid Papillary Carcinoma1
2CompletedTreatmentDisease-Free Survival / Neoplasms, Hormone-Dependent / Prostatic Neoplasms / Survival Rate / Tumor Markers, Biological1
2CompletedTreatmentEsophageal Cancers2
2CompletedTreatmentExtensive-Stage Small Cell Lung Cancer1
2CompletedTreatmentFibrosarcomas malignant / Leiomyosarcomas / Liposarcoma / Malignant Fibrous Histiocytoma1
2CompletedTreatmentGastrointestinal Stromal Tumors2
2CompletedTreatmentGlioblastomas1
2CompletedTreatmentHepatic Metastases / Metastatic Colorectal Cancers1
2CompletedTreatmentHepatocellular,Carcinoma / Liver Cancer1
2CompletedTreatmentIslet Cell Tumor / Neuroendocrine Tumors1
2CompletedTreatmentLiver Cancer1
2CompletedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)5
2CompletedTreatmentLung Cancer Small Cell Lung Cancer (SCLC)1
2CompletedTreatmentLung Cancers1
2CompletedTreatmentMalignant Neoplasm of Pancreas2
2CompletedTreatmentMelanoma (Skin) / Metastatic Cancers / Renal Cancers1
2CompletedTreatmentMetastatic Breast Cancer (MBC)1
2CompletedTreatmentMetastatic Cancers / Renal Cancers1
2CompletedTreatmentMetastatic Hormone Refractory Prostate Cancer1
2CompletedTreatmentMetastatic Melanoma1
2CompletedTreatmentMetastatic Renal Cell Carcinoma3
2CompletedTreatmentMetastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma / Recurrent Metastatic Squamous Neck Cancer With Occult Primary / Recurrent Squamous Cell Carcinoma of the Hypopharynx / Recurrent Squamous Cell Carcinoma of the Larynx / Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity / Recurrent Squamous Cell Carcinoma of the Nasopharynx / Recurrent Squamous Cell Carcinoma of the Oropharynx / Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity / Stage IV Squamous Cell Carcinoma of the Hypopharynx / Stage IV Squamous Cell Carcinoma of the Larynx / Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity / Stage IV Squamous Cell Carcinoma of the Nasopharynx / Stage IV Squamous Cell Carcinoma of the Oropharynx / Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity1
2CompletedTreatmentNeoplasm Metastases / Renal Cell Adenocarcinoma1
2CompletedTreatmentNeoplasms, Breast4
2CompletedTreatmentNeoplasms, Colorectal1
2CompletedTreatmentNeoplasms, Hepatic / Unresectable Hepatocellular Carcinoma1
2CompletedTreatmentNeuroendocrine Tumors1
2CompletedTreatmentNon-clear Cell Renal Cell Cancer1
2CompletedTreatmentParaganglioma / Pheochromocytomas1
2CompletedTreatmentPatients With Advanced Urothelial Carcinoma1
2CompletedTreatmentProgressive Neuroendocrine Tumors of pancreatic origin1
2CompletedTreatmentProstate Cancer1
2CompletedTreatmentProstate Cancer / Prostatectomy1
2CompletedTreatmentRecurrent Bladder Cancer / Transitional Cell Carcinoma of the Bladder1
2CompletedTreatmentRecurrent Fallopian Tube Cancer / Recurrent Ovarian Epithelial Cancer / Recurrent Primary Peritoneal Cavity Cancer / Stage IIIA Fallopian Tube Cancer / Stage IIIA Ovarian Epithelial Cancer / Stage IIIA Primary Peritoneal Cavity Cancer / Stage IIIB Fallopian Tube Cancer / Stage IIIB Ovarian Epithelial Cancer / Stage IIIB Primary Peritoneal Cavity Cancer / Stage IIIC Fallopian Tube Cancer / Stage IIIC Ovarian Epithelial Cancer / Stage IIIC Primary Peritoneal Cavity Cancer / Stage IV Fallopian Tube Cancer / Stage IV Ovarian Epithelial Cancer / Stage IV Primary Peritoneal Cavity Cancer1
2CompletedTreatmentRecurrent Thyroid Cancer / Stage IVA Follicular Thyroid Cancer / Stage IVA Papillary Thyroid Cancer / Stage IVB Follicular Thyroid Cancer / Stage IVB Papillary Thyroid Cancer / Stage IVC Follicular Thyroid Cancer / Stage IVC Papillary Thyroid Cancer / Thyroid Gland Medullary Carcinoma1
2CompletedTreatmentRecurrent Uterine Sarcoma / Uterine Leiomyosarcoma1
2CompletedTreatmentRefractory Multiple Myeloma / Stage I Multiple Myeloma / Stage II Multiple Myeloma / Stage III Multiple Myeloma1
2CompletedTreatmentRelapsed or Cisplatin-Refractory Germ Cell Cancer1
2CompletedTreatmentRenal Cancers4
2CompletedTreatmentRenal Cancers / Renal Cell Adenocarcinoma1
2CompletedTreatmentRenal Cell Adenocarcinoma7
2CompletedTreatmentStomach Neoplasms1
2CompletedTreatmentUnresectable and Advanced Cholangiocarcinoma1
2CompletedTreatmentUnresectable or Metastatic Colorectal Cancer1
2CompletedTreatmentUrothelial Cancer1
2CompletedTreatmentVon Hippel-Lindau Disease1
2Enrolling by InvitationTreatmentRenal Cell Adenocarcinoma1
2Not Yet RecruitingTreatmentAdvanced Solid Tumors / Multiple Myeloma (MM) / Non-Hodgkin's Lymphoma (NHL)1
2Not Yet RecruitingTreatmentMetastatic Renal Cell Carcinoma1
2Not Yet RecruitingTreatmentPancreatic Neuroendocrine Tumour Metastatic1
2Not Yet RecruitingTreatmentRenal Cell Adenocarcinoma1
2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Myelogenous Leukaemia (AML) / Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome / Chronic Myelomonocytic Leukemia / Myelodysplastic Syndrome / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Refractory Adult Acute Lymphoblastic Leukemia1
2RecruitingTreatmentAdvanced Malignant Neoplasm / Advanced Malignant Solid Neoplasm / Bladder Carcinoma / Carcinoma, Breast / Carcinoma, Colorectal / Carcinoma, Pancreatic / Cervical Carcinoma / Colon Carcinoma / Endometrial Carcinoma / Gastric Carcinoma / Gliomas / Head and Neck Carcinoma / Liver and Intrahepatic Bile Duct Carcinoma / Lung, Carcinoma / Malignant Lymphomas / Malignant Uterine Neoplasm / Melanoma / Oesophageal Carcinoma / Ovarian Carcinoma / Plasma Cell Myeloma / Prostate Cancer / Rectal Carcinoma / Recurrent Bladder Carcinoma / Recurrent Breast Carcinoma / Recurrent Cervical Carcinoma / Recurrent Colon Carcinoma / Recurrent Colorectal Carcinoma / Recurrent Esophageal Carcinoma / Recurrent Gastric Carcinoma / Recurrent Gliomas / Recurrent Head and Neck Carcinoma / Recurrent Liver Carcinoma / Recurrent Lung Carcinoma / Recurrent Lymphoma / Recurrent Malignant Solid Neoplasm / Recurrent Melanoma / Recurrent Ovarian Carcinoma / Recurrent Pancreatic Carcinoma / Recurrent Plasma Cell Myeloma / Recurrent Prostate Carcinoma / Recurrent Rectal Carcinoma / Recurrent Skin Carcinoma / Recurrent Solid Neoplasm / Recurrent Thyroid Gland Carcinoma / Recurrent Uterine Corpus Carcinoma / Refractory Lymphomas / Refractory Malignant Neoplasm / Refractory Malignant Solid Neoplasm / Refractory Plasma Cell Myeloma / Renal Carcinoma / Skin Carcinoma / Solid Neoplasms / Thyroid Gland Carcinoma / Uterine Corpus Cancer1
2RecruitingTreatmentAdvanced Solid Tumors / Multiple Myeloma (MM) / Non-Hodgkin's Lymphoma (NHL)1
2RecruitingTreatmentAlveolar Soft Part Sarcoma (ASPS)1
2RecruitingTreatmentCancer, Breast1
2RecruitingTreatmentCancer, Breast / Lung Cancer Non-Small Cell Cancer (NSCLC) / Malignant Neoplasm of Stomach / Prostate Cancer / Tumors, Solid1
2RecruitingTreatmentCiliary Body and Choroid Melanoma, Medium/Large Size / Ciliary Body and Choroid Melanoma, Small Size / Iris Melanoma / Stage I Intraocular Melanoma / Stage IIA Intraocular Melanoma / Stage IIB Intraocular Melanoma / Stage IIIA Intraocular Melanoma / Stage IIIB Intraocular Melanoma / Stage IIIC Intraocular Melanoma1
2RecruitingTreatmentClear Cell Metastatic Renal Cell Carcinoma1
2RecruitingTreatmentClear Cell Renal Cell Carcinoma1
2RecruitingTreatmentClear Cell Renal Cell Carcinoma / Clear-cell Kidney Carcinoma / RCC / Renal Cancers1
2RecruitingTreatmentGlioblastoma Multiforme1
2RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC) / Small Cell Lung Carcinoma / Thymic Carcinoma1
2RecruitingTreatmentMalignant Progressive Pheochromocytoma and Paraganglioma (PPGL)1
2RecruitingTreatmentMetastatic Renal Cell Cancer / Neoplasms, Kidney1
2RecruitingTreatmentMetastatic Renal Cell Carcinoma2
2RecruitingTreatmentNeoplasms, Pancreatic / Neuroendocrine Tumors1
2RecruitingTreatmentNeuroendocrine Tumors1
2RecruitingTreatmentPancreatic Neuroendocrine Carcinoma1
2RecruitingTreatmentRenal Cancers1
2RecruitingTreatmentRenal Cell Adenocarcinoma1
2RecruitingTreatmentRenal Cell Carcinoma Recurrent / Stage III Renal Cell Cancer / Stage IV Renal Cell Cancer / Type 1 Papillary Renal Cell Carcinoma / Type 2 Papillary Renal Cell Carcinoma1
2RecruitingTreatmentRenal Cell Carcinoma, Metastatic1
2SuspendedTreatmentNeurofibromatosis / NF1 / Plexiform Neurofibromas1
2TerminatedTreatmentAccelerated Phase Chronic Myelogenous Leukemia / Acute Undifferentiated Leukemia (AUL) / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative / Blastic Phase Chronic Myelogenous Leukemia / Chronic Myelomonocytic Leukemia / Chronic Phase Chronic Myelogenous Leukemia / Leukemia, Prolymphocytic / Malignant mast cell neoplasm / Meningeal Chronic Myelogenous Leukemia / Primary Myelofibrosis / Progressive Hairy Cell Leukemia, Initial Treatment / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Refractory Chronic Lymphocytic Leukemia / Refractory Hairy Cell Leukemia / Relapsing Chronic Myelogenous Leukemia / Secondary Acute Myeloid Leukemia / Stage I Chronic Lymphocytic Leukemia / Stage II Chronic Lymphocytic Leukemia / Stage III Chronic Lymphocytic Leukemia / Stage IV Chronic Lymphocytic Leukemia / T-Cell Large Granular Lymphocyte Leukemia / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Adult Acute Myeloid Leukemia / Untreated Hairy Cell Leukemia1
2TerminatedTreatmentAdult Primary Hepatocellular Carcinoma / Advanced Adult Primary Liver Cancer / Localized Unresectable Adult Primary Liver Cancer / Recurrent Adult Primary Liver Cancer1
2TerminatedTreatmentAdvanced Disease / Neoplasms, Pancreatic / Neuroendocrine Tumors / Sunitinib1
2TerminatedTreatmentAnaplastic Gliomas / Glioblastoma Multiforme / Malignant Gliomas1
2TerminatedTreatmentAscites1
2TerminatedTreatmentBladder Cancers1
2TerminatedTreatmentBladder Cancers / Transitional Cell Carcinoma1
2TerminatedTreatmentCancer, Breast1
2TerminatedTreatmentChemo-refractory Melanoma1
2TerminatedTreatmentCognitive/Functional Effects / Metastatic Cancers / Unspecified Adult Solid Tumor, Protocol Specific1
2TerminatedTreatmentFibrolamellar Hepatocellular Carcinoma / Hepatocellular,Carcinoma1
2TerminatedTreatmentGenitourinary Disease1
2TerminatedTreatmentHemangioblastomas / Renal Cell Adenocarcinoma / Von Hippel-Lindau Syndrome1
2TerminatedTreatmentIntraocular Melanoma / Malignant Conjunctival Neoplasm1
2TerminatedTreatmentLiver Cancer2
2TerminatedTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
2TerminatedTreatmentLung Cancers1
2TerminatedTreatmentMetastatic Breast Cancer (MBC)1
2TerminatedTreatmentMetastatic Colorectal Cancers1
2TerminatedTreatmentMetastatic Renal Cell Carcinoma2
2TerminatedTreatmentNeoplasms, Colorectal1
2TerminatedTreatmentPalliative Treatment / Recurrent Disease / Squamous Cell Head and Neck Carcinoma1
2TerminatedTreatmentProstate Cancer1
2TerminatedTreatmentRenal Cancers1
2TerminatedTreatmentRenal Cell Adenocarcinoma3
2TerminatedTreatmentTransitional Cell Carcinoma of the Bladder1
2TerminatedTreatmentTumors, Solid1
2Unknown StatusBasic ScienceHormone Refractory Prostate Cancer1
2Unknown StatusTreatmentAdrenocortical Carcinoma1
2Unknown StatusTreatmentAdults / Bladder Cancers / Urothelial Cancer1
2Unknown StatusTreatmentAdverse Effects / Cancer, Ovarian1
2Unknown StatusTreatmentBladder Cancers / Transitional Cell Cancer of the Renal Pelvis and Ureter / Urethral Cancer2
2Unknown StatusTreatmentCancers / Lung Cancers1
2Unknown StatusTreatmentClear Cell Renal Cell Carcinoma / Metastasis1
2Unknown StatusTreatmentGastro Intestinal Stromal Tumor1
2Unknown StatusTreatmentGlioblastoma Multiforme1
2Unknown StatusTreatmentHormone Refractory / Prostate Cancer1
2Unknown StatusTreatmentIntraocular Melanoma1
2Unknown StatusTreatmentLung Cancer Metastatic / Renal Cell Adenocarcinoma1
2Unknown StatusTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)2
2Unknown StatusTreatmentMetastatic Renal Cell Cancer / Renal Cell Adenocarcinoma1
2Unknown StatusTreatmentMetastatic Renal Cell Carcinoma1
2Unknown StatusTreatmentRenal Cancers3
2Unknown StatusTreatmentSoft Tissue Sarcoma (STS)1
2WithdrawnTreatmentClassic Kaposi Sarcoma / Kaposi's Sarcoma AIDS Related1
2WithdrawnTreatmentColorectal Cancers / Metastatic Cancers1
2WithdrawnTreatmentLocally Metastatic Malignant Neoplasm1
2WithdrawnTreatmentLung Cancers1
2WithdrawnTreatmentMelanoma1
2WithdrawnTreatmentRenal Cell Adenocarcinoma2
2, 3Active Not RecruitingTreatmentLiver Cancer1
2, 3Not Yet RecruitingTreatmentGBM / Glioblastoma Multiforme / Glioblastoma, Adult / Glioblastomas / Recurrent Brain Tumors1
3Active Not RecruitingTreatmentAdvanced Renal Cell Carcinoma / Metastatic Renal Cell Carcinoma1
3Active Not RecruitingTreatmentAdvanced Renal Cell Carcinoma / Metastatic Renal Cell Carcinoma / Renal Cell Adenocarcinoma1
3Active Not RecruitingTreatmentNeoplasms, Kidney1
3Active Not RecruitingTreatmentRenal Cell Adenocarcinoma2
3CompletedTreatmentClear Cell Renal Cell Carcinoma / Stage I Renal Cell Cancer / Stage II Renal Cell Cancer / Stage III Renal Cell Cancer1
3CompletedTreatmentGastrointestinal Stromal Tumors1
3CompletedTreatmentMetastatic Colorectal Cancers1
3CompletedTreatmentMetastatic Renal Cell Carcinoma1
3CompletedTreatmentNeoplasms, Breast3
3CompletedTreatmentNon-Small Cell Lung Carcinoma (NSCLC)1
3CompletedTreatmentRenal Cell Adenocarcinoma3
3CompletedTreatmentStage IIIb Non-small Cell Lung Cancer / Stage IV Non-Small Cell Lung Cancer1
3Not Yet RecruitingTreatmentLocally Advanced or Metastatic Renal Cell Carcinoma1
3RecruitingTreatmentCarcinoma NOS / Enzyme Inhibitors / Kidney Diseases / Neoplasms by Site / Neoplasms, Kidney / Protein Kinase Inhibitors / Renal Cell Adenocarcinoma / Urologic Neoplasms1
3RecruitingTreatmentRenal Cell Adenocarcinoma4
3TerminatedTreatmentCarcinoma, Islet Cell / Carcinoma, Pancreatic1
3TerminatedTreatmentGastrointestinal Stromal Tumors1
3TerminatedTreatmentHepatocellular,Carcinoma1
3TerminatedTreatmentNeoplasms, Breast1
3TerminatedTreatmentProstatic Neoplasms1
3Unknown StatusTreatmentGastrointestinal Stromal Tumors1
4Active Not RecruitingNot AvailableWell-differentiated Pancreatic Neuroendocrine Tumor1
4CompletedTreatmentGastrointestinal Neoplasms, Gastrointestinal Stromal Tumors1
4CompletedTreatmentGastrointestinal Stroma Tumors / Lung Cancer Non-Small Cell Cancer (NSCLC) / Renal-cell Cancer1
4CompletedTreatmentRenal Cell Adenocarcinoma1
4Not Yet RecruitingTreatmentRefractory Solid Tumors1
4RecruitingOtherMetastatic Renal Cell Cancer1
4TerminatedNot AvailableMetastatic Renal Cell Carcinoma2
4TerminatedTreatmentMetastatic Renal Cell Carcinoma1
Not AvailableActive Not RecruitingDiagnosticAdvanced Solid Tumors / Cancers1
Not AvailableActive Not RecruitingDiagnosticRenal Cell Adenocarcinoma / Stage III Renal Cell Cancer / Stage IV Renal Cell Cancer1
Not AvailableApproved for MarketingNot AvailableNeoplasms, Gastrointestinal1
Not AvailableApproved for MarketingNot AvailableRenal Cell Adenocarcinoma1
Not AvailableCompletedNot AvailableAdvanced or Metastatic Renal Cell Carcinoma / Renal Cancers1
Not AvailableCompletedNot AvailableGastrointestinal Stromal Tumors2
Not AvailableCompletedNot AvailableMetastatic Clear Cell Renal Cell Carcinoma1
Not AvailableCompletedNot AvailableMetastatic Renal Cell Carcinoma1
Not AvailableCompletedNot AvailableNeoplasms / Renal Cell Adenocarcinoma1
Not AvailableCompletedNot AvailableRenal Cell Adenocarcinoma3
Not AvailableCompletedDiagnosticKidney (Renal Cell) Cancer / Neoplasms, Kidney / Renal Cell Adenocarcinoma1
Not AvailableCompletedTreatmentAdvanced Breast Cancer / Advanced Gastric Cancer / Advanced/Metastatic Non-Small Cell Lung Cancer / Gastrointestinal Stromal Tumors / Hepatocellular,Carcinoma / Lung Cancer Non-Small Cell Cancer (NSCLC) / Malignant neoplasm of islets of Langerhans / Metastatic Breast Cancer [F] / Metastatic Castration Resistant Prostate Cancer / Metastatic Renal Cell Cancer / Progressive Neuroendocrine Tumors of pancreatic origin / Thyroid Cancers1
Not AvailableCompletedTreatmentMetastatic Renal Cell Carcinoma1
Not AvailableCompletedTreatmentNeoplasms1
Not AvailableCompletedTreatmentRenal Cancers2
Not AvailableCompletedTreatmentTumors, Solid1
Not AvailableNot Yet RecruitingNot AvailableRenal Neoplasms / Targeted Molecular Therapy1
Not AvailableRecruitingNot AvailableCarcinoma, Renal Cell, Advanced / Gastrointestinal Stroma Tumors / Lymphoma, Mantle-Cell1
Not AvailableRecruitingNot AvailableComplete Remission in Renal Cell Carcinoma1
Not AvailableRecruitingNot AvailableMetastatic Renal Cell Carcinoma1
Not AvailableRecruitingNot AvailablePancreatic Neuroendocrine Tumor, Well Differentiated and Progressive1
Not AvailableRecruitingNot AvailableProgressive Neuroendocrine Tumors of pancreatic origin1
Not AvailableRecruitingDiagnosticCancers / High-Grade Gliomas1
Not AvailableRecruitingSupportive CareDiarrhea / Metastatic Renal Cell Cancer / Stage IV Renal Cell Cancer1
Not AvailableRecruitingTreatmentRefractory Solid Tumors1
Not AvailableTerminatedNot AvailableColorectal Cancers / Hepatocellular Cancer / Lung Cancer Non-Small Cell Cancer (NSCLC) / Renal Cell Adenocarcinoma1
Not AvailableTerminatedSupportive CareRecurrent Renal Cell Cancer / Stage IV Renal Cell Cancer / Tiredness1
Not AvailableTerminatedTreatmentRenal Cell Adenocarcinoma1
Not AvailableTerminatedTreatmentTumors1
Not AvailableUnknown StatusDiagnosticRenal Cancers1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Dosage forms
FormRouteStrength
CapsuleOral12.5 mg
CapsuleOral12.5 mg/1
CapsuleOral25 mg/1
CapsuleOral25 mg
CapsuleOral37.5 mg
CapsuleOral37.5 mg/1
CapsuleOral50 mg/1
CapsuleOral50 mg
Prices
Unit descriptionCostUnit
Sutent 50 mg capsule333.39USD capsule
Sutent 25 mg capsule187.28USD capsule
Sutent 12.5 mg capsule93.64USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
CA2395461No2010-05-252020-12-22Canada
CA2399358No2006-03-212021-02-15Canada
US6573293No2001-02-152021-02-15Us
US7211600No2000-12-222020-12-22Us
US7125905No2001-02-152021-02-15Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
water solubility>25 mg/mL over pH of 1.2 to 6.8FDA label
logP5.2 FDA label
pKa8.95 FDA label
Predicted Properties
PropertyValueSource
Water Solubility0.0308 mg/mLALOGPS
logP3.24ALOGPS
logP2.93ChemAxon
logS-4.1ALOGPS
pKa (Strongest Acidic)11.46ChemAxon
pKa (Strongest Basic)9.04ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area77.23 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity116.27 m3·mol-1ChemAxon
Polarizability44.32 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9938
Blood Brain Barrier+0.7993
Caco-2 permeable-0.5948
P-glycoprotein substrateSubstrate0.8648
P-glycoprotein inhibitor IInhibitor0.6809
P-glycoprotein inhibitor IINon-inhibitor0.5466
Renal organic cation transporterNon-inhibitor0.7385
CYP450 2C9 substrateNon-substrate0.8727
CYP450 2D6 substrateNon-substrate0.7716
CYP450 3A4 substrateSubstrate0.641
CYP450 1A2 substrateNon-inhibitor0.5626
CYP450 2C9 inhibitorNon-inhibitor0.6437
CYP450 2D6 inhibitorNon-inhibitor0.6846
CYP450 2C19 inhibitorNon-inhibitor0.6261
CYP450 3A4 inhibitorNon-inhibitor0.5991
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.7032
Ames testNon AMES toxic0.5699
CarcinogenicityNon-carcinogens0.784
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.6794 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8597
hERG inhibition (predictor II)Inhibitor0.8398
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as indolines. These are compounds containing an indole moiety, which consists of pyrrolidine ring fused to benzene to form 2,3-dihydroindole.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Indoles and derivatives
Sub Class
Indolines
Direct Parent
Indolines
Alternative Parents
Pyrrole carboxamides / Substituted pyrroles / Aryl fluorides / Benzenoids / Vinylogous amides / Heteroaromatic compounds / Trialkylamines / Secondary carboxylic acid amides / Amino acids and derivatives / Lactams
show 6 more
Substituents
Dihydroindole / Pyrrole-3-carboxamide / Pyrrole-3-carboxylic acid or derivatives / Aryl fluoride / Aryl halide / Substituted pyrrole / Benzenoid / Pyrrole / Heteroaromatic compound / Vinylogous amide
show 20 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
monocarboxylic acid amide, pyrroles (CHEBI:38940)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Vascular endothelial growth factor binding
Specific Function
Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic...
Gene Name
PDGFRB
Uniprot ID
P09619
Uniprot Name
Platelet-derived growth factor receptor beta
Molecular Weight
123966.895 Da
References
  1. Mendel DB, Laird AD, Xin X, Louie SG, Christensen JG, Li G, Schreck RE, Abrams TJ, Ngai TJ, Lee LB, Murray LJ, Carver J, Chan E, Moss KG, Haznedar JO, Sukbuntherng J, Blake RA, Sun L, Tang C, Miller T, Shirazian S, McMahon G, Cherrington JM: In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res. 2003 Jan;9(1):327-37. [PubMed:12538485]
  2. Abrams TJ, Lee LB, Murray LJ, Pryer NK, Cherrington JM: SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol Cancer Ther. 2003 May;2(5):471-8. [PubMed:12748309]
  3. Baratte S, Sarati S, Frigerio E, James CA, Ye C, Zhang Q: Quantitation of SU1 1248, an oral multi-target tyrosine kinase inhibitor, and its metabolite in monkey tissues by liquid chromatograph with tandem mass spectrometry following semi-automated liquid-liquid extraction. J Chromatogr A. 2004 Jan 23;1024(1-2):87-94. [PubMed:14753710]
  4. Pietras K, Hanahan D: A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J Clin Oncol. 2005 Feb 10;23(5):939-52. Epub 2004 Nov 22. [PubMed:15557593]
  5. Gollob JA: Sorafenib: scientific rationales for single-agent and combination therapy in clear-cell renal cell carcinoma. Clin Genitourin Cancer. 2005 Dec;4(3):167-74. [PubMed:16425993]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Vegf-b-activated receptor activity
Specific Function
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell ...
Gene Name
FLT1
Uniprot ID
P17948
Uniprot Name
Vascular endothelial growth factor receptor 1
Molecular Weight
150767.185 Da
References
  1. O'Farrell AM, Foran JM, Fiedler W, Serve H, Paquette RL, Cooper MA, Yuen HA, Louie SG, Kim H, Nicholas S, Heinrich MC, Berdel WE, Bello C, Jacobs M, Scigalla P, Manning WC, Kelsey S, Cherrington JM: An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients. Clin Cancer Res. 2003 Nov 15;9(15):5465-76. [PubMed:14654525]
  2. Roskoski R Jr: Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor. Biochem Biophys Res Commun. 2007 May 4;356(2):323-8. Epub 2007 Mar 7. [PubMed:17367763]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Transmembrane receptor protein tyrosine kinase activity
Specific Function
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell main...
Gene Name
KIT
Uniprot ID
P10721
Uniprot Name
Mast/stem cell growth factor receptor Kit
Molecular Weight
109863.655 Da
References
  1. Abrams TJ, Lee LB, Murray LJ, Pryer NK, Cherrington JM: SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol Cancer Ther. 2003 May;2(5):471-8. [PubMed:12748309]
  2. Schueneman AJ, Himmelfarb E, Geng L, Tan J, Donnelly E, Mendel D, McMahon G, Hallahan DE: SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models. Cancer Res. 2003 Jul 15;63(14):4009-16. [PubMed:12873999]
  3. Joensuu H: Second line therapies for the treatment of gastrointestinal stromal tumor. Curr Opin Oncol. 2007 Jul;19(4):353-8. [PubMed:17545799]
  4. Baratte S, Sarati S, Frigerio E, James CA, Ye C, Zhang Q: Quantitation of SU1 1248, an oral multi-target tyrosine kinase inhibitor, and its metabolite in monkey tissues by liquid chromatograph with tandem mass spectrometry following semi-automated liquid-liquid extraction. J Chromatogr A. 2004 Jan 23;1024(1-2):87-94. [PubMed:14753710]
  5. Roskoski R Jr: Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor. Biochem Biophys Res Commun. 2007 May 4;356(2):323-8. Epub 2007 Mar 7. [PubMed:17367763]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Vascular endothelial growth factor-activated receptor activity
Specific Function
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and ...
Gene Name
KDR
Uniprot ID
P35968
Uniprot Name
Vascular endothelial growth factor receptor 2
Molecular Weight
151525.555 Da
References
  1. Mendel DB, Laird AD, Xin X, Louie SG, Christensen JG, Li G, Schreck RE, Abrams TJ, Ngai TJ, Lee LB, Murray LJ, Carver J, Chan E, Moss KG, Haznedar JO, Sukbuntherng J, Blake RA, Sun L, Tang C, Miller T, Shirazian S, McMahon G, Cherrington JM: In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res. 2003 Jan;9(1):327-37. [PubMed:12538485]
  2. Schueneman AJ, Himmelfarb E, Geng L, Tan J, Donnelly E, Mendel D, McMahon G, Hallahan DE: SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models. Cancer Res. 2003 Jul 15;63(14):4009-16. [PubMed:12873999]
  3. Baratte S, Sarati S, Frigerio E, James CA, Ye C, Zhang Q: Quantitation of SU1 1248, an oral multi-target tyrosine kinase inhibitor, and its metabolite in monkey tissues by liquid chromatograph with tandem mass spectrometry following semi-automated liquid-liquid extraction. J Chromatogr A. 2004 Jan 23;1024(1-2):87-94. [PubMed:14753710]
  4. Schoffski P, Dumez H, Clement P, Hoeben A, Prenen H, Wolter P, Joniau S, Roskams T, Van Poppel H: Emerging role of tyrosine kinase inhibitors in the treatment of advanced renal cell cancer: a review. Ann Oncol. 2006 Aug;17(8):1185-96. Epub 2006 Jan 17. [PubMed:16418310]
  5. Amino N, Ideyama Y, Yamano M, Kuromitsu S, Tajinda K, Samizu K, Hisamichi H, Matsuhisa A, Shirasuna K, Kudoh M, Shibasaki M: YM-359445, an orally bioavailable vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, has highly potent antitumor activity against established tumors. Clin Cancer Res. 2006 Mar 1;12(5):1630-8. [PubMed:16533791]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Vascular endothelial growth factor-activated receptor activity
Specific Function
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardi...
Gene Name
FLT4
Uniprot ID
P35916
Uniprot Name
Vascular endothelial growth factor receptor 3
Molecular Weight
152755.94 Da
References
  1. Roskoski R Jr: Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor. Biochem Biophys Res Commun. 2007 May 4;356(2):323-8. Epub 2007 Mar 7. [PubMed:17367763]
  2. Deprimo SE, Bello CL, Smeraglia J, Baum CM, Spinella D, Rini BI, Michaelson MD, Motzer RJ: Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins. J Transl Med. 2007 Jul 2;5:32. [PubMed:17605814]
  3. Katoh Y, Katoh M: Comparative integromics on VEGF family members. Int J Oncol. 2006 Jun;28(6):1585-9. [PubMed:16685460]
  4. Gridelli C, Maione P, Del Gaizo F, Colantuoni G, Guerriero C, Ferrara C, Nicolella D, Comunale D, De Vita A, Rossi A: Sorafenib and sunitinib in the treatment of advanced non-small cell lung cancer. Oncologist. 2007 Feb;12(2):191-200. [PubMed:17296815]
  5. Ahmed SI, Thomas AL, Steward WP: Vascular endothelial growth factor (VEGF) inhibition by small molecules. J Chemother. 2004 Nov;16 Suppl 4:59-63. [PubMed:15688612]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Vascular endothelial growth factor-activated receptor activity
Specific Function
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells...
Gene Name
FLT3
Uniprot ID
P36888
Uniprot Name
Receptor-type tyrosine-protein kinase FLT3
Molecular Weight
112902.51 Da
References
  1. O'Farrell AM, Abrams TJ, Yuen HA, Ngai TJ, Louie SG, Yee KW, Wong LM, Hong W, Lee LB, Town A, Smolich BD, Manning WC, Murray LJ, Heinrich MC, Cherrington JM: SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood. 2003 May 1;101(9):3597-605. Epub 2003 Jan 16. [PubMed:12531805]
  2. O'Farrell AM, Foran JM, Fiedler W, Serve H, Paquette RL, Cooper MA, Yuen HA, Louie SG, Kim H, Nicholas S, Heinrich MC, Berdel WE, Bello C, Jacobs M, Scigalla P, Manning WC, Kelsey S, Cherrington JM: An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients. Clin Cancer Res. 2003 Nov 15;9(15):5465-76. [PubMed:14654525]
  3. Baratte S, Sarati S, Frigerio E, James CA, Ye C, Zhang Q: Quantitation of SU1 1248, an oral multi-target tyrosine kinase inhibitor, and its metabolite in monkey tissues by liquid chromatograph with tandem mass spectrometry following semi-automated liquid-liquid extraction. J Chromatogr A. 2004 Jan 23;1024(1-2):87-94. [PubMed:14753710]
  4. Schmidt-Arras D, Schwable J, Bohmer FD, Serve H: Flt3 receptor tyrosine kinase as a drug target in leukemia. Curr Pharm Des. 2004;10(16):1867-83. [PubMed:15180525]
  5. Yee KW, Schittenhelm M, O'Farrell AM, Town AR, McGreevey L, Bainbridge T, Cherrington JM, Heinrich MC: Synergistic effect of SU11248 with cytarabine or daunorubicin on FLT3 ITD-positive leukemic cells. Blood. 2004 Dec 15;104(13):4202-9. Epub 2004 Aug 10. [PubMed:15304385]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Protein homodimerization activity
Specific Function
Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor ...
Gene Name
CSF1R
Uniprot ID
P07333
Uniprot Name
Macrophage colony-stimulating factor 1 receptor
Molecular Weight
107982.955 Da
References
  1. Guo J, Marcotte PA, McCall JO, Dai Y, Pease LJ, Michaelides MR, Davidsen SK, Glaser KB: Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors. Mol Cancer Ther. 2006 Apr;5(4):1007-13. [PubMed:16648572]
  2. Roskoski R Jr: Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor. Biochem Biophys Res Commun. 2007 May 4;356(2):323-8. Epub 2007 Mar 7. [PubMed:17367763]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Inhibitor
General Function
Vascular endothelial growth factor-activated receptor activity
Specific Function
Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chem...
Gene Name
PDGFRA
Uniprot ID
P16234
Uniprot Name
Platelet-derived growth factor receptor alpha
Molecular Weight
122668.46 Da
References
  1. Prenen H, Cools J, Mentens N, Folens C, Sciot R, Schoffski P, Van Oosterom A, Marynen P, Debiec-Rychter M: Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate. Clin Cancer Res. 2006 Apr 15;12(8):2622-7. [PubMed:16638875]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A5
Uniprot ID
P20815
Uniprot Name
Cytochrome P450 3A5
Molecular Weight
57108.065 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Oxygen binding
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP3A7
Uniprot ID
P24462
Uniprot Name
Cytochrome P450 3A7
Molecular Weight
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Atpase activity, coupled to transmembrane movement of substances
Specific Function
May be an organic anion pump relevant to cellular detoxification.
Gene Name
ABCC4
Uniprot ID
O15439
Uniprot Name
Multidrug resistance-associated protein 4
Molecular Weight
149525.33 Da
References
  1. Hu S, Chen Z, Franke R, Orwick S, Zhao M, Rudek MA, Sparreboom A, Baker SD: Interaction of the multikinase inhibitors sorafenib and sunitinib with solute carriers and ATP-binding cassette transporters. Clin Cancer Res. 2009 Oct 1;15(19):6062-9. doi: 10.1158/1078-0432.CCR-09-0048. Epub 2009 Sep 22. [PubMed:19773380]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Hu S, Chen Z, Franke R, Orwick S, Zhao M, Rudek MA, Sparreboom A, Baker SD: Interaction of the multikinase inhibitors sorafenib and sunitinib with solute carriers and ATP-binding cassette transporters. Clin Cancer Res. 2009 Oct 1;15(19):6062-9. doi: 10.1158/1078-0432.CCR-09-0048. Epub 2009 Sep 22. [PubMed:19773380]
  2. Shukla S, Robey RW, Bates SE, Ambudkar SV: Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2. Drug Metab Dispos. 2009 Feb;37(2):359-65. doi: 10.1124/dmd.108.024612. Epub 2008 Oct 29. [PubMed:18971320]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Organic anion transmembrane transporter activity
Specific Function
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name
ABCC2
Uniprot ID
Q92887
Uniprot Name
Canalicular multispecific organic anion transporter 1
Molecular Weight
174205.64 Da
References
  1. Hu S, Chen Z, Franke R, Orwick S, Zhao M, Rudek MA, Sparreboom A, Baker SD: Interaction of the multikinase inhibitors sorafenib and sunitinib with solute carriers and ATP-binding cassette transporters. Clin Cancer Res. 2009 Oct 1;15(19):6062-9. doi: 10.1158/1078-0432.CCR-09-0048. Epub 2009 Sep 22. [PubMed:19773380]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Xenobiotic-transporting atpase activity
Specific Function
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both fro...
Gene Name
ABCG2
Uniprot ID
Q9UNQ0
Uniprot Name
ATP-binding cassette sub-family G member 2
Molecular Weight
72313.47 Da
References
  1. Hu S, Chen Z, Franke R, Orwick S, Zhao M, Rudek MA, Sparreboom A, Baker SD: Interaction of the multikinase inhibitors sorafenib and sunitinib with solute carriers and ATP-binding cassette transporters. Clin Cancer Res. 2009 Oct 1;15(19):6062-9. doi: 10.1158/1078-0432.CCR-09-0048. Epub 2009 Sep 22. [PubMed:19773380]
  2. Dai CL, Liang YJ, Wang YS, Tiwari AK, Yan YY, Wang F, Chen ZS, Tong XZ, Fu LW: Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2. Cancer Lett. 2009 Jun 28;279(1):74-83. doi: 10.1016/j.canlet.2009.01.027. Epub 2009 Feb 18. [PubMed:19232821]
  3. Shukla S, Robey RW, Bates SE, Ambudkar SV: Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2. Drug Metab Dispos. 2009 Feb;37(2):359-65. doi: 10.1124/dmd.108.024612. Epub 2008 Oct 29. [PubMed:18971320]

Drug created on May 16, 2007 14:11 / Updated on November 19, 2017 20:33