Sulfonylureas

DrugDrug NameDrug Indication
DB00672ChlorpropamideFor treatment of NIDDM in conjunction with diet and exercise.
DB00839TolazamideFor use as an adjunct to diet to lower the blood glucose in patients with non-insulin dependent diabetes mellitus (Type II) whose hyperglycemia cannot be satisfactorily controlled by diet alone.
DB01016GlyburideIndicated as an adjunct to diet to lower the blood glucose in patients with NIDDM whose hyperglycemia cannot be satisfactorily controlled by diet alone.
DB01067GlipizideFor use as an adjunct to diet for the control of hyperglycemia and its associated symptomatology in patients with non-insulin-dependent diabetes mellitus (NIDDM; type II), formerly known as maturity-onset diabetes, after an adequate trial of dietary therapy has proved unsatisfactory.
DB01120GliclazideFor the treatment of NIDDM in conjunction with diet and exercise.
DB00222GlimepirideFor concomitant use with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus.
DB01124TolbutamideFor treatment of NIDDM (non-insulin-dependent diabetes mellitus) in conjunction with diet and exercise.
DB00414AcetohexamideUsed in the management of diabetes mellitus type 2 (adult-onset).
DB01251GliquidoneUsed in the treatment of diabetes mellitus type 2.
DB01289GlisoxepideFor the treatment of diabetes mellitus type 2.
DB08962GlibornurideNot Available
DrugDrug NameTargetType
DB00672ChlorpropamideCytochrome P450 2C9enzyme
DB00672ChlorpropamideCytochrome P450 2C19enzyme
DB00672ChlorpropamideProstaglandin G/H synthase 1enzyme
DB00672ChlorpropamideATP-binding cassette sub-family C member 8target
DB00672ChlorpropamideSolute carrier family 15 member 1transporter
DB00672ChlorpropamideSolute carrier family 15 member 2transporter
DB00672ChlorpropamideSolute carrier family 22 member 6transporter
DB00839TolazamideCytochrome P450 2C9enzyme
DB00839TolazamideSulfonylurea receptor 1, Kir6.2target
DB01016GlyburideSerum albumincarrier
DB01016GlyburideCytochrome P450 2C9enzyme
DB01016GlyburideCytochrome P450 2C19enzyme
DB01016GlyburideCytochrome P450 3A4enzyme
DB01016GlyburideATP-binding cassette sub-family C member 9target
DB01016GlyburideBile salt export pumptarget
DB01016GlyburideATP-binding cassette sub-family A member 1target
DB01016GlyburideCystic fibrosis transmembrane conductance regulatortarget
DB01016GlyburideSulfonylurea receptor 1, Kir6.2target
DB01016GlyburideG protein-activated inward rectifier potassium channel 4target
DB01016GlyburideMitochondrial ATP-sensitive potassium channeltarget
DB01016GlyburideCarnitine O-palmitoyltransferase 1, liver isoformtarget
DB01016GlyburideCanalicular multispecific organic anion transporter 2transporter
DB01016GlyburideBile salt export pumptransporter
DB01016GlyburideMultidrug resistance protein 1transporter
DB01016GlyburideMultidrug resistance-associated protein 1transporter
DB01016GlyburideSolute carrier family 15 member 1transporter
DB01016GlyburideSolute carrier organic anion transporter family member 1A2transporter
DB01016GlyburideSolute carrier family 15 member 2transporter
DB01016GlyburideSolute carrier family 22 member 6transporter
DB01016GlyburideCanalicular multispecific organic anion transporter 1transporter
DB01016GlyburideATP-binding cassette sub-family G member 2transporter
DB01016GlyburideSolute carrier family 22 member 7transporter
DB01016GlyburideSolute carrier organic anion transporter family member 2B1transporter
DB01067GlipizideCytochrome P450 2C9enzyme
DB01067GlipizideCytochrome P450 3A4enzyme
DB01067GlipizideUDP-glucuronosyltransferase 1-1enzyme
DB01067GlipizidePeroxisome proliferator-activated receptor gammatarget
DB01067GlipizideATP-binding cassette sub-family C member 8target
DB01067GlipizideBile salt export pumptransporter
DB01120GliclazideSerum albumincarrier
DB01120GliclazideCytochrome P450 2C9enzyme
DB01120GliclazideCytochrome P450 2C19enzyme
DB01120GliclazideATP-binding cassette sub-family C member 8target
DB01120GliclazideVascular endothelial growth factor Atarget
DB00222GlimepirideCytochrome P450 2C9enzyme
DB00222GlimepirideATP-sensitive inward rectifier potassium channel 1target
DB00222GlimepirideATP-sensitive inward rectifier potassium channel 11target
DB00222GlimepirideATP-binding cassette sub-family C member 8target
DB00222GlimepirideBile salt export pumptransporter
DB01124TolbutamideSerum albumincarrier
DB01124TolbutamideCytochrome P450 2C19enzyme
DB01124TolbutamideCytochrome P450 2C9enzyme
DB01124TolbutamideCytochrome P450 2C8enzyme
DB01124TolbutamideCytochrome P450 2C18enzyme
DB01124TolbutamideATP-sensitive inward rectifier potassium channel 1target
DB01124TolbutamideATP-binding cassette sub-family C member 8target
DB01124TolbutamideSolute carrier family 15 member 1transporter
DB01124TolbutamideSolute carrier organic anion transporter family member 1A2transporter
DB01124TolbutamideSolute carrier family 15 member 2transporter
DB01124TolbutamideSolute carrier family 22 member 6transporter
DB01124TolbutamideSolute carrier organic anion transporter family member 2B1transporter
DB00414AcetohexamideSerum albumincarrier
DB00414AcetohexamideCarbonyl reductase [NADPH] 1enzyme
DB00414AcetohexamideCytochrome P450 2C9enzyme
DB00414AcetohexamideATP-sensitive inward rectifier potassium channel 1target
DB01251GliquidoneCytochrome P450 2C9enzyme
DB01251GliquidoneATP-binding cassette sub-family C member 8target
DB01251GliquidoneATP-sensitive inward rectifier potassium channel 8target
DB01289GlisoxepideCytochrome P450 2C9enzyme
DB01289GlisoxepideATP-sensitive inward rectifier potassium channel 8target
DB08962GlibornurideCytochrome P450 2C9enzyme