Thyroid Products

A glycoprotein hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Thyrotropin stimulates THYROID GLAND by increasing the iodide transport, synthesis and release of thyroid hormones (THYROXINE and TRIIODOTHYRONINE). Thyrotropin consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the pituitary glycoprotein hormones (TSH; LUTEINIZING HORMONE and FSH), but the beta subunit is unique and confers its biological specificity.
DrugDrug NameDrug Description
DB00024Thyrotropin alfaA recombinant form of thyroid stimulating hormone used in diagnostic testing for thyroid cancer and alongside radioactive agents to destroy thyroid tissue.
DB03604TiratricolA metabolite of T3 and T4 thyroid hormones; promoted for hyperlipidemia, localized lipodystrophy, and obesity. Tiratricol has been used in trials studying the treatment of Allan-Herndon-Dudley Syndrome.
DB00279LiothyronineA thyroid hormone replacement therapy used to treat hypothyroidism, to suppress TSH, and to help in the diagnosis of hyperthyroidism.
DB00451LevothyroxineA synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer.
DB01583LiotrixMay be used to treat primary, secondary or tertiary hypothyroidism. May also be used to suppress thyroid stimulating hormone (TSH) secretion in patients with simple (nontoxic) goiter, subacute or chronic...
DB09100Thyroid, porcineA naturally-occurring peptide hormone used for the replacement therapy for hypothyroidism of any etiology, treatment for euthyroid goiters, and management of thyroid cancers.
DB00066FollitropinA form of recombinant human follicle stimulating hormone used to stimulate follicle development in women with primary ovarian hypogonadism and in men with hypogonadotropic hypogonadism.
DB06285TeriparatideA recombinant parathyroid hormone used for the treatment of osteoporosis.
DB126293,5-diiodothyropropionic acidDITPA has been investigated in Congestive Heart Failure.
DB00389CarbimazoleFor the treatment of hyperthyroidism and thyrotoxicosis. It is also used to prepare patients for thyroidectomy.
DB00550PropylthiouracilA thiourea antithyroid agent used to treat hyperthyroidism.
DB00763MethimazoleA thionamide antithyroid agent that inhibits the actions of thyroid peroxidase, leading to a reduction in thyroid hormone synthesis and amelioration of hyperthyroidism.
DB07637DibromotyrosineNot Available
DB09418Potassium perchlorateNo current FDA- or EMA-approved therapeutic indications.
DB13644MethylthiouracilNot Annotated
DB13804BenzylthiouracilNot Annotated
DB06715Potassium IodideAn oral antithyroid agent used for the prevention of radioactive iodine uptake into the thyroid gland during a nuclear radiation emergency.
DB09421ProtirelinA synthetic analogue of thyrotropin-releasing hormone that has been used during diagnostic tests to evaluate function of the thyroid gland.
DB05829Parathyroid hormoneAn analog of human parathyroid hormone (PTH) used to treat hypocalcemia caused by hypoparathyroidism.
DB00017Salmon CalcitoninA synthetic peptide form of calcitonin used to inhibit bone resorption in the treatment of hypercalcemia, osteoporosis, and Paget's disease.
DB05084AbaloparatideA parathyroid hormone-related protein (PTHrP) analog used for the treatment of osteoporosis in postmenopausal women with a high risk of fracture.
DB15263ThyrotropinThyrotropin is under investigation in clinical trial NCT01348191 (Detection of Thyrotrophin Receptor in Human Myometrium).
DB13742ElcatoninNot Annotated
DB033743,5-DiiodotyrosineA product from the iodination of MONOIODOTYROSINE. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones...
DrugDrug NameTargetType
DB00024Thyrotropin alfaThyrotropin receptortarget
DB03604TiratricolThyroid hormone receptor betatarget
DB00279LiothyronineThyroid hormone receptor betatarget
DB00279LiothyronineThyroid hormone receptor alphatarget
DB00279LiothyronineThyroxine-binding globulincarrier
DB00279LiothyronineTransthyretincarrier
DB00279LiothyronineSerum albumincarrier
DB00279LiothyronineP-glycoprotein 1transporter
DB00279LiothyronineSolute carrier family 22 member 8transporter
DB00279LiothyronineMonocarboxylate transporter 10transporter
DB00279LiothyronineSolute carrier organic anion transporter family member 4A1transporter
DB00279LiothyronineSolute carrier organic anion transporter family member 1C1transporter
DB00279LiothyronineSolute carrier organic anion transporter family member 1A2transporter
DB00279LiothyronineSodium/bile acid cotransportertransporter
DB00279LiothyronineSolute carrier organic anion transporter family member 4C1transporter
DB00279LiothyronineSolute carrier organic anion transporter family member 1B3transporter
DB00279LiothyronineSolute carrier organic anion transporter family member 1B1transporter
DB00279LiothyronineLarge neutral amino acids transporter small subunit 1transporter
DB00279LiothyronineProliferating cell nuclear antigentarget
DB00279LiothyronineUDP-glucuronosyltransferase 1-1enzyme
DB00451LevothyroxineThyroid hormone receptor alphatarget
DB00451LevothyroxineThyroid hormone receptor betatarget
DB00451LevothyroxineCytochrome P450 2C8enzyme
DB00451LevothyroxineTransthyretincarrier
DB00451LevothyroxineSerum albumincarrier
DB00451LevothyroxineThyroxine-binding globulincarrier
DB00451LevothyroxineP-glycoprotein 1transporter
DB00451LevothyroxineMonocarboxylate transporter 8transporter
DB00451LevothyroxineSolute carrier organic anion transporter family member 1C1transporter
DB00451LevothyroxineSolute carrier organic anion transporter family member 1A2transporter
DB00451LevothyroxineSolute carrier organic anion transporter family member 1B1transporter
DB00451LevothyroxineSolute carrier organic anion transporter family member 1B3transporter
DB00451LevothyroxineSolute carrier organic anion transporter family member 4A1transporter
DB00451LevothyroxineSolute carrier organic anion transporter family member 4C1transporter
DB00451LevothyroxineLarge neutral amino acids transporter small subunit 1transporter
DB00451LevothyroxineUDP-glucuronosyltransferase 1-1enzyme
DB00451LevothyroxineSolute carrier organic anion transporter family member 2B1transporter
DB00451LevothyroxineIntegrin alpha-Vtarget
DB00451LevothyroxineIntegrin beta-3target
DB00451LevothyroxineP-glycoprotein 1enzyme
DB01583LiotrixThyroid hormone receptor alphatarget
DB01583LiotrixThyroid hormone receptor betatarget
DB01583LiotrixCytochrome P450 2C8enzyme
DB01583LiotrixSolute carrier organic anion transporter family member 1A2transporter
DB01583LiotrixSolute carrier organic anion transporter family member 1B1transporter
DB01583LiotrixSolute carrier organic anion transporter family member 1B3transporter
DB01583LiotrixSolute carrier organic anion transporter family member 4C1transporter
DB01583LiotrixSodium/bile acid cotransportertransporter
DB01583LiotrixSolute carrier organic anion transporter family member 1C1transporter
DB01583LiotrixSolute carrier organic anion transporter family member 4A1transporter
DB01583LiotrixSolute carrier family 22 member 8transporter
DB01583LiotrixMonocarboxylate transporter 8transporter
DB01583LiotrixMonocarboxylate transporter 10transporter
DB01583LiotrixP-glycoprotein 1transporter
DB01583LiotrixTransthyretincarrier
DB01583LiotrixThyroxine-binding globulincarrier
DB01583LiotrixSerum albumincarrier
DB01583LiotrixCytochrome P450 3A4enzyme
DB00066FollitropinFollicle-stimulating hormone receptortarget
DB06285TeriparatideParathyroid hormone/parathyroid hormone-related peptide receptortarget
DB126293,5-diiodothyropropionic acidCytochrome P450 3A4enzyme
DB00389CarbimazoleThyroid peroxidasetarget
DB00389CarbimazoleCytochrome P450 19A1enzyme
DB00550PropylthiouracilThyroid peroxidasetarget
DB00550PropylthiouracilMyeloperoxidaseenzyme
DB00550PropylthiouracilDopamine beta-hydroxylaseenzyme
DB00550PropylthiouracilCytochrome P450 1A1enzyme
DB00763MethimazoleThyroid peroxidasetarget
DB00763MethimazoleCytochrome P450 1A2enzyme
DB00763MethimazoleCytochrome P450 2A6enzyme
DB00763MethimazoleCytochrome P450 2B6enzyme
DB00763MethimazoleCytochrome P450 2C19enzyme
DB00763MethimazoleCytochrome P450 2C9enzyme
DB00763MethimazoleCytochrome P450 2D6enzyme
DB00763MethimazoleCytochrome P450 2E1enzyme
DB00763MethimazoleCytochrome P450 3A4enzyme
DB00763MethimazoleDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB07637DibromotyrosineErythropoietin receptortarget
DB09418Potassium perchlorateSodium/iodide cotransportertarget
DB09418Potassium perchlorateSerum albumincarrier
DB06715Potassium IodideTyrosinetarget
DB09421ProtirelinThyrotropin Releasing Hormone Receptortarget
DB05829Parathyroid hormoneParathyroid hormone/parathyroid hormone-related peptide receptortarget
DB05829Parathyroid hormoneParathyroid hormone 2 receptortarget
DB00017Salmon CalcitoninCalcitonin receptortarget
DB05084AbaloparatideParathyroid hormone/parathyroid hormone-related peptide receptortarget
DB033743,5-DiiodotyrosinecAMP-dependent protein kinase inhibitor alphatarget
DB033743,5-DiiodotyrosinecAMP-dependent protein kinase catalytic subunit alphatarget
DB033743,5-DiiodotyrosineAlpha-amylase G-6target
DB033743,5-DiiodotyrosineTrypsin-1target
DB033743,5-DiiodotyrosineNickel-binding periplasmic proteintarget
DB033743,5-DiiodotyrosineIodotyrosine dehalogenase 1target