NamePotassium Iodide
Accession NumberDB06715
TypeSmall Molecule

Saturated solution of Potassium Iodide (SSKI) is used pharmaceutically for emergency use in patients experiencing acute symptoms of severe hyperglycemia (also known as thyroid storm or thyrotoxic crisis). SSKI can also be used for radioiodine-contamination emergencies or in preparation of thyrotoxic patients for thyroidectomy.

Potassium iodide
External IDs NSC-77362
Product Ingredients Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ThyrosafeTablet65 mgOralRecip Ab2003-11-042008-07-07Canada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Iodine Ctr Srt 300mgTablet, extended release300 mcgOralBioenergy Inc.1979-12-311998-06-03Canada
IosatTablet65 mg/1OralAnbex Inc.2013-05-01Not applicableUs
IosatTablet130 mg/1OralAnbex Inc.1982-10-14Not applicableUs
Potassium IodideSolution65 mg/mLOralMission Pharmacal2016-05-15Not applicableUs
Thyroblock Tab 130mgTablet130 mgOralCarter Horner Corp.1981-12-312003-03-14Canada
ThyrosafeTablet65 mg/1OralRecipharm Ab (Publ)2002-09-30Not applicableUs
ThyroshieldSolution65 mg/mLOralFleming & Company, Pharmaceuticals2005-04-01Not applicableUs
ThyroshieldSolution65 mg/mLOralArco Pharmaceuticals LLC2014-09-01Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
SskiSolution1 g/mLOralUpsher Smith Laboratories1973-04-30Not applicableUs
International BrandsNot Available
Brand mixtures
Central-vite 18 EssentialVita Health Products Inc
Century CompleteVita Health Products Inc
Citranatal DHAMission Pharmacal
Citranatal RxMission Pharmacal
Complete Multivitamins and Minerals Tablets Timed ReleasePharmetics (2011) Inc.
DiodineProduits Marc O (1987) Inc., Division Of Technilab Inc.
Foltabs PrenatalMidlothian Laboratories
Formula Fe-vitamin and Mineral TabMetagenics, Inc.
Fusion Activator Formula TabL & S Research Corporation
Gesticare DHAJazz Pharmaceuticals Commercial Corp.
Hemarexin TabLab Bio Chimique Inc.,Division Of Technilab Pharma Inc.
Hemenatal OBWh Nutritionals, Llc
Humco Strong Iodine SolutionHumco Holding Group. Inc.
Humco Strong Iodine TinctureHumo Holding Group, Inc.
Hypo Vites TabPharmetics (2011) Inc.
I D M Expectorant TabRougier Pharma Division Of Ratiopharm Inc
I.D.M. SolutionRougier Pharma Division Of Ratiopharm Inc
Idm TabRougier Pharma Division Of Ratiopharm Inc
Inatal UltraNnodum Pharmaceuticals
IodineBorisovskiy Zavod Medicinskikh Preparatov Jsc
Iodine Tct 2.5% BPStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Iodine Tct 5% CFStanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Iodine Tincture 21/2%Ingram And Bell Inc.
Iron Polysaccharides Folic Acid DHAVirtus Pharmaceuticals
Kanga-V Multivitamins & MineralsLacombe Drugs (1992) Ltd
Lugols Strong IodineCooper Surgical, Inc.
M.T.E.-6 ConcentratedLyphomed, Division Of Fujisawa Canada Inc.
Mathieu Cough SyrupJ L Mathieu Cie Ltee
MetrateMedic Laboratory LtÉe
Mor-vites TabPharmetics (2011) Inc.
Multi Vitamin - MineralEnrich International
Multi Vitamin-mineral FormulaVita Health Products Inc
Multiple Vitamin Plus Minerals TabHall Laboratories, Ltd.
Multiple Vitamins and Minerals TabRandle Pharmaceutical Inc.
Multiple Vitamins With Minerals TabletsPharmetics (2011) Inc.
Multivitamines Et Mineraux Reguliers / Regular Multivitamins and MineralsVita Health Products Inc
Multivitamins and Minerals - CompleteVita Health Products Inc
Multivitamins and Multiminerals Formula Regular TabletPharmetics (2011) Inc.
Nutrilite Double XNutrilite, A Division Of Access Business Group, Llc
OnccorSimone Protective Pharmaceuticals, Inc.
One A Day Advance AdultsBayer Inc Consumer Care
One A Day Advance Adults 50+Bayer Inc Consumer Care
PhytopureLaboratoire Lalco Inc.
PNF-FirstAcella Pharmaceuticals, LLC
Pnv-selectAcella Pharmaceuticals, LLC
Potassium Plus Vit B ComplexAnabolic Laboratories Inc.
Prefera Ob Plus DHAAlaven Pharmaceutical
PreferaobMeda Pharmaceuticals Ltd
Preferaob OneMeda Pharmaceuticals Ltd
Preferaob Plus DHAAlaven Pharmaceutical
PregvitDuchesnay Inc.
Pregvit Folic 4Duchesnay Inc.
Pregvit Folic 5Duchesnay Inc.
Prenatal Chelated MineralUsana Health Sciences, Inc.
Prenate EliteAvion Pharmaceuticals, Llc
Prenate EnhanceAvion Pharmaceuticals, Llc
Prenate EssentialAvion Pharmaceuticals, Llc
Prenate PixieAvion Pharmaceuticals, Llc
Prenate StarAvion Pharmaceuticals, Llc
PretabVirtus Pharmaceuticals
Q.T. Vitamin and Mineral Drink MixGarden State Nutritionals
Qkit Procedure TrayCooper Surgical, Inc.
Ratio-theo-broncRatiopharm Inc Division Of Teva Canada Limited
Revival 1 TabBio Vita
Sels MexicainProduits Francais Labs Inc.
Spectrum 2 CapNf Formulas Inc.
Super Daily No 2W.R. Enterprises Inc.
Tincture Of IodineLawton's Drug Stores Ltd.
Tincture Of Iodine 2.5%D.C. Labs Limited
Tincture Of Iodine 5%D.C. Labs Limited
Virt-PNVirtus Pharmaceuticals
Virt-PN PlusVirtus Pharmaceuticals
Vitafol UltraEverett Laboratories, Inc.
Vitalife - CapsuleHolista Health (Canada) Inc.
Vito Bronches SiropDuchesnay Inc.
VP-heme OBVirtus Pharmaceuticals
VP-heme OneVirtus Pharmaceuticals
Women's FormulaPro Ma Systems
CAS number7681-11-0
WeightAverage: 166.0028
Monoisotopic: 165.868175281
Chemical FormulaIK
potassium iodide

Potassium Iodide is oral antithyroid agent. Potassium Iodide is used as an adjunct to other antithyroid agents in the treatment of hyperthyroidism and thyrotoxicosis and preoperatively to induce thyroid involution.

Structured Indications

It works in the thyroid gland. By inhibiting thyroid hormone synthesis and release, thyroid gland vascularity is reduced, thyroid gland tissue becomes firmer, thyroid cell size is reduced, follicular colloid reaccumulates, and bound iodine levels increase. As a protectant following radiation exposure, KI blocks the uptake of radioactive iodine isotopes by the thyroid gland thereby minimizing the risk of radiation-induced thyroid neoplasms.

Mechanism of action
TargetKindPharmacological actionActionsOrganismUniProt ID
TyrosineSmall moleculeunknown
Humannot applicabledetails
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Drug Interactions
DrugInteractionDrug group
LithiumPotassium Iodide may increase the hypothyroid activities of Lithium.Approved
Food InteractionsNot Available
Synthesis Reference

Stanley D. Lazarus, "Production of thermally stabilized polyester with alkylene carbonates and sodium or potassium iodide." U.S. Patent US4327207, issued October, 1973.

General ReferencesNot Available
External Links
ATC CodesR05CA02 — Potassium iodideV03AB21 — Potassium iodideS01XA04 — Potassium iodide
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
Clinical Trials
Clinical Trials
2CompletedTreatmentMalignant Lymphomas1
2TerminatedTreatmentNon-Hodgkin's Lymphoma (NHL)1
3CompletedPreventionCariostatic Agents / Dental Decay1
3CompletedTreatmentDental Plaque1
3RecruitingPreventionHeart Failure, Unspecified1
4CompletedDiagnosticCoronary Artery Disease / Coronary Stenosis1
4CompletedTreatmentGraves Diseases / Hyperthyroidism1
4CompletedTreatmentHyperemesis Gravidarum / Morning Sickness / Nausea / Pregnancy / Vomiting1
4Unknown StatusTreatmentAmputation Wound / Wound Infections1
Not AvailableRecruitingTreatmentMetastatic Pheochromocytoma / Relapsed Neuroblastoma1
Not AvailableRecruitingTreatmentRoot Canal Disinfection1
ManufacturersNot Available
PackagersNot Available
Dosage forms
Tablet, extended releaseOral
Tablet, extended releaseOral300 mcg
TabletOral130 mg/1
TabletOral65 mg/1
Tablet, effervescentOral
Tablet, coatedOral
Capsule, liquid filledOral
SolutionOral1 g/mL
TabletOral130 mg
TabletOral65 mg
SolutionOral65 mg/mL
Tablet, film coatedOral
Capsule, gelatin coatedOral
PricesNot Available
PatentsNot Available
Experimental PropertiesNot Available
Predicted Properties
Physiological Charge1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Human Intestinal Absorption+0.7647
Blood Brain Barrier+0.9702
Caco-2 permeable+0.6625
P-glycoprotein substrateNon-substrate0.8989
P-glycoprotein inhibitor INon-inhibitor0.984
P-glycoprotein inhibitor IINon-inhibitor0.9854
Renal organic cation transporterNon-inhibitor0.9282
CYP450 2C9 substrateNon-substrate0.8261
CYP450 2D6 substrateNon-substrate0.7789
CYP450 3A4 substrateNon-substrate0.7857
CYP450 1A2 substrateNon-inhibitor0.7164
CYP450 2C9 inhibitorNon-inhibitor0.8527
CYP450 2D6 inhibitorNon-inhibitor0.9142
CYP450 2C19 inhibitorNon-inhibitor0.8842
CYP450 3A4 inhibitorNon-inhibitor0.9317
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9022
Ames testNon AMES toxic0.6838
CarcinogenicityCarcinogens 0.659
BiodegradationNot ready biodegradable0.5913
Rat acute toxicity2.9202 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9535
hERG inhibition (predictor II)Non-inhibitor0.9657
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Mass Spec (NIST)Not Available
SpectraNot Available
DescriptionThis compound belongs to the class of chemical entities known as alkali metal iodides. These are inorganic compounds in which the largest halogen atom is Iodine, and the heaviest metal atom is an alkali metal.
KingdomChemical entities
Super ClassInorganic compounds
ClassMixed metal/non-metal compounds
Sub ClassAlkali metal salts
Direct ParentAlkali metal iodides
Alternative ParentsInorganic salts
SubstituentsAlkali metal iodide / Inorganic salt
Molecular FrameworkNot Available
External Descriptorspotassium salt (CHEBI:8346 )


Small molecule
Pharmacological action
  1. Pisarev MA, Aiello LO: Studies on the mechanism of action of potassium iodide on thyroid protein biosynthesis. Acta Endocrinol (Copenh). 1976 Jun;82(2):298-305. [PubMed:946922 ]
  2. Foldes J, Gesztesi E, Juhasz J: Mechanism of action of di-iodotyrosine and of iodine. Acta Med Acad Sci Hung. 1974;31(1-2):131-7. [PubMed:4464746 ]
Drug created on May 16, 2010 17:39 / Updated on June 24, 2017 13:27