Potassium Iodide

Identification

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Name
Potassium Iodide
Accession Number
DB06715
Type
Small Molecule
Groups
Approved
Description

Saturated solution of Potassium Iodide (SSKI) is used pharmaceutically for emergency use in patients experiencing acute symptoms of severe hyperglycemia (also known as thyroid storm or thyrotoxic crisis). SSKI can also be used for radioiodine-contamination emergencies or in preparation of thyrotoxic patients for thyroidectomy.

Structure
Thumb
Synonyms
  • Kaliumiodid
  • KI
  • Potasio ioduro
  • Potassium iodide
External IDs
NSC-77362
Active Moieties
NameKindUNIICASInChI Key
Potassium cationionic295O53K15224203-36-9NPYPAHLBTDXSSS-UHFFFAOYSA-N
Iodideionic09G4I6V86Q20461-54-5XMBWDFGMSWQBCA-UHFFFAOYSA-M
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
SskiSolution1 g/1mLOralAvondale Pharmaceuticals, Llc2017-11-13Not applicableUs
SskiSolution1 g/1mLOralUpsher-Smith Laboratories, LLC1973-04-30Not applicableUs
ThyroSafeTablet65 mgOralRecip Ab2003-11-042008-07-07Canada
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
IodineCapsule0.22 mgOralThorne Research Inc.1997-09-092006-08-04Canada
Iodine Ctr Srt 300mgTablet, extended release300 mcgOralBioenergy Inc.1979-12-311998-06-03Canada
Iodine Tab 0.5mgTablet.5 mgOralCreative Nutrition Canada Corp.1986-12-311998-07-16Canada
IosatTablet130 mg/1OralAnbex Inc.1982-10-14Not applicableUs
IosatTablet65 mg/1OralAnbex Inc.2013-05-01Not applicableUs
Potassium IodideSolution65 mg/1mLOralMission Pharmacal Company2016-05-15Not applicableUs
RadibanTablet130 mg/1OralUnited Douglas Pharm., Inc.2011-12-20Not applicableUs
Theraplex F Tab 0.12mgTablet0.09 mgOralTherapeutic Foods Co.1989-12-312009-07-24Canada
Thyroblock Tab 130mgTablet130 mgOralCarter Horner Corp.1981-12-312003-03-14Canada
ThyroSafeTablet65 mg/1OralRecipharm Ab (Publ)2002-09-30Not applicableUs
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
24 Multivitamins + MineralsPotassium Iodide (.1 mg) + Ascorbic acid (150 mg) + Beta carotene (10000 unit) + Biotin (25 mcg) + Calcium (130 mg) + Cholecalciferol (400 unit) + Choline bitartrate (25 mg) + Chromium (20 mcg) + Copper (1 mg) + Cyanocobalamin (25 mcg) + Ferrous fumarate (15 mg) + Folic acid (.8 mg) + Inositol (25 mg) + Magnesium (65 mg) + Manganese (2 mg) + Molybdenum (20 mcg) + Niacin (25 mg) + Calcium pantothenate (25 mg) + Potassium (15 mg) + Pyridoxine hydrochloride (25 mg) + Racemethionine (25 mg) + Riboflavin (25 mg) + Selenium (20 mcg) + Thiamine hydrochloride (25 mg) + Vanadium (20 mcg) + Vitamin A palmitate (5000 unit) + Vitamin E (50 unit) + Zinc (10 mg)TabletOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1997-04-302002-07-31Canada
50 Plus Multiple Vitamins & MineralsPotassium Iodide (0.15 mg) + Ascorbic acid (90 mg) + Biotin (45 mcg) + Calcium (200 mg) + Cholecalciferol (400 unit) + Chromium (10 mcg) + Copper (2 mg) + Cyanocobalamin (25 mcg) + Folic acid (0.4 mg) + Magnesium (100 mg) + Manganese (5 mg) + Molybdenum (25 mcg) + Nicotinamide (40 mg) + Pantothenic acid (10 mg) + Pyridoxine hydrochloride (3 mg) + Riboflavin (3.2 mg) + Selenium (25 mcg) + Thiamine mononitrate (2.25 mg) + Vanadium (10 mcg) + Vitamin A palmitate (6000 unit) + Zinc (15 mg)TabletOralGfr Pharma Ltd.2002-10-202004-06-15Canada
Bear EssentialsPotassium Iodide (0.0304 mg) + Ascorbic acid (12 mg) + Cholecalciferol (80 unit) + Cyanocobalamin (1.2 mcg) + Folic acid (0.080 mg) + Pantothenic acid (2 mg) + Vitamin A (1000 unit) + Vitamin E (6 unit)TabletOralHealth Asure, Inc.2003-07-022008-06-24Canada
Body RoxPotassium Iodide (0.05 mg) + Beta carotene (3000.0 unit) + Biotin (100.0 mcg) + Calcium (75.0 mg) + Calcium ascorbate (167.0 mg) + Cholecalciferol (133.0 unit) + Choline bitartrate (15.0 mg) + Chromium (50.0 mcg) + Copper (0.33 mg) + Cyanocobalamin (20.0 mcg) + Folic acid (0.267 mg) + Inositol (10.0 mg) + Magnesium (37.5 mg) + Manganese (1.0 mg) + Molybdenum (15.0 mcg) + Niacin (1.66 mg) + Nicotinamide (3.3 mg) + Calcium pantothenate (10.0 mg) + Pyridoxine hydrochloride (3.0 mg) + Riboflavin (3.0 mg) + Selenium (40.0 mcg) + Silicon (1.0 mg) + Thiamine hydrochloride (3.0 mg) + Vanadium (10.0 mcg) + Zinc (4.0 mg) + alpha-Tocopherol succinate (66.7 unit)TabletOralUsana Health Sciences, Inc.2003-09-022008-06-27Canada
C. Vit-min FormulaPotassium Iodide (0.15 mg) + Ascorbic acid (100 mg) + Biotin (30 mcg) + Calcium (175 mg) + Cholecalciferol (400 unit) + Choline (30 mg) + Chromium (50 mcg) + Copper (5 mg) + Cyanocobalamin (100 mcg) + Ferrous fumarate (10 mg) + Folic acid (0.600 mg) + Inositol (30 mg) + Magnesium (80 mg) + Manganese (5 mg) + Molybdenum (25 mcg) + Nicotinamide (50 mg) + Calcium pantothenate (50 mg) + Potassium (40 mg) + Pyridoxine hydrochloride (50 mg) + Racemethionine (3 mg) + Riboflavin (50 mg) + Sodium selenite (200 mcg) + Silicon (0.01 mg) + Thiamine (50 mg) + Vanadium (10 mcg) + Vitamin A (5000 unit) + Zinc (40 mg) + alpha-Tocopherol acetate (100 unit)TabletOralNutramed Laboratories Inc.Not applicableNot applicableCanada
Central-vite 18 EssentialPotassium Iodide (0.15 mg) + Ascorbic acid (90 mg) + Beta carotene (3000 unit) + Biotin (45 mcg) + Calcium (175 mg) + Calcium Phosphate (125 mg) + Cholecalciferol (400 unit) + Cupric oxide (2 mg) + Cyanocobalamin (9 mcg) + Ferrous fumarate (10 mg) + Folic acid (0.4 mg) + Magnesium (100 mg) + Nicotinamide (40 mg) + Calcium pantothenate (10 mg) + Pyridoxine hydrochloride (3 mg) + Riboflavin (3.2 mg) + Thiamine mononitrate (2.25 mg) + Vitamin A (2000 unit) + alpha-Tocopherol acetate (25 unit)TabletOralVita Health Products Inc1998-04-242002-07-31Canada
Century CompletePotassium Iodide (.15 mg) + Ascorbic acid (90 mg) + Beta carotene (3000 unit) + Biotin (45 mcg) + Calcium (175 mg) + Calcium Phosphate (125 mg) + Cupric oxide (2 mg) + Cyanocobalamin (9 mcg) + Ferrous fumarate (10 mg) + Folic acid (.4 mg) + Magnesium (100 mg) + Nicotinamide (40 mg) + Calcium pantothenate (10 mg) + Pyridoxine hydrochloride (3 mg) + Riboflavin (3.2 mg) + Thiamine mononitrate (2.25 mg) + Vitamin A (2000 unit) + Vitamin D (400 unit) + alpha-Tocopherol acetate (25 unit)TabletOralVita Health Products Inc1998-03-172002-07-31Canada
Chela Potassium PlusPotassium Iodide (.1 mg) + Folic acid (.4 mg) + Nicotinamide (10 mg) + Potassium (99 mg) + Riboflavin (2 mg) + Thiamine hydrochloride (2 mg)TabletOralNu Life Nutrition Ltd.1988-12-312000-03-03Canada
Children's Chewable Multivitamin and MultimineralPotassium Iodide (0.15 mg) + Ascorbic acid (60 mg) + Beta carotene (250 unit) + Biotin (20 mcg) + Calcium (162 mg) + Calcium Phosphate (125 mg) + Cupric oxide (2 mg) + Cyanocobalamin (5 mcg) + Ferrous fumarate (4 mg) + Folic acid (0.3 mg) + Nicotinamide (15 mg) + Calcium pantothenate (5 mg) + Pyridoxine hydrochloride (1.7 mg) + Riboflavin (1.4 mg) + Thiamine mononitrate (1.2 mg) + Vitamin A (2750 unit) + Vitamin D (400 unit) + Vitamin E (15 unit)TabletOralJamieson Laboratories Ltd2006-09-202009-07-29Canada
Children's Chewable TabPotassium Iodide (.016 mg) + Ascorbic acid (33.33 mg) + Beta carotene (333.3 unit) + Biotin (33 mcg) + Chromic chloride (2.2 mcg) + Cyanocobalamin (7.33 mcg) + Folic acid (.1 mg) + Magnesium (23.33 mg) + Manganese sulfate (1.82 mg) + Molybdenum (.7 mcg) + Niacin (.33 mg) + Nicotinamide (2.66 mg) + Calcium pantothenate (5 mg) + Potassium (9.44 mg) + Pyridoxine hydrochloride (1.66 mg) + Racemethionine (2.66 mg) + Riboflavin (1 mg) + Sodium selenite (2.6 mcg) + Thiamine mononitrate (1.66 mg) + Vitamin A palmitate (333.3 unit) + Zinc (.95 mg) + alpha-Tocopherol succinate (15 unit)TabletOralNf Formulas Inc.1988-12-312000-06-21Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
BumP DHAPotassium Iodide (250 ug/1) + Cobamamide (500 mg/1) + Flavin adenine dinucleotide (1 mg/1) + Flavin mononucleotide (2 mg/1) + Iron (15 mg/1) + Leucovorin (1 mg/1) + Levomefolate magnesium (1 mg/1) + Magnesium oxide (125 mg/1) + NADH (25 ug/1) + Omega-3 fatty acids (300 mg/1) + Pyridoxal phosphate (5 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Zinc glycinate (15 1/1)CapsuleOralCenturion Labs2017-03-242017-04-17Us
Cavan Heme OBPotassium Iodide (175 ug/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Iron (28 mg/1) + Niacin (17 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Sodium selenate (65 ug/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (15 mg/1) + alpha-Tocopherol succinate (10 [iU]/1)TabletOralSeton Pharmaceuticals2010-08-032012-06-10Us
Cavan PrenatalPotassium Iodide (150 ug/1) + Ascorbic acid (120 mg/1) + Calcium Carbonate (200 mg/1) + Cholecalciferol (420 [iU]/1) + Choline bitartrate (55 mg/1) + Cyanocobalamin (8 ug/1) + Ferrous fumarate (28 mg/1) + Folic acid (1 mg/1) + Niacin (20 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Thiamine mononitrate (3 mg/1) + Vitamin E (30 [iU]/1) + Zinc oxide (15 ug/1)TabletOralSeton Pharmaceuticals2009-07-092009-07-22Us
CitraNatal 90 DHAPotassium Iodide (150 ug/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (159 mg/1) + Cupric oxide (2 mg/1) + Docusate sodium (50 mg/1) + Ferrous gluconate dihydrate (5 mg/1) + Folic acid (1 mg/1) + Iron (85 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Thiamine mononitrate (4.54 mg/1) + Vitamin D (400 [iU]/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)TabletOralMission Pharmacal Company2014-04-11Not applicableUs
CitraNatal DHAPotassium Iodide (150 mg/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (124 mg/1) + Cupric oxide (2 mg/1) + Doconexent (250 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Icosapent (0.625 mg/1) + Iron (27 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Vitamin D (400 [iU]/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)KitMission Pharmacal Company2014-05-22Not applicableUs
CitraNatal DHAPotassium Iodide (150 mg/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (125 mg/1) + Cupric oxide (2 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Iron (27 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Vitamin D (400 [iU]/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)TabletOralMission Pharmacal2007-11-20Not applicableUs
CitraNatal RxPotassium Iodide (150 mg/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (125 mg/1) + Cupric oxide (2 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Iron (27 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Vitamin D (400 [iU]/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)TabletOralMission Pharmacal2007-11-26Not applicableUs
CitraNatal RxPotassium Iodide (150 mg/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (124 mg/1) + Cupric oxide (2 mg/1) + Folic acid (1 mg/1) + Iron (27 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Vitamin D (400 [iU]/1) + Zinc oxide (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)TabletOralMission Pharmacal2014-08-11Not applicableUs
Foltabs PrenatalPotassium Iodide (150 ug/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (125 mg/1) + Cholecalciferol (400 [iU]/1) + Cupric oxide (2 mg/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Docusate sodium (50 mg/1) + Ferrous gluconate dihydrate (13 mg/1) + Folic acid (1 mg/1) + Iron (14 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Riboflavin (3.4 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (25 mg/1)TabletOralMayne Pharma2009-01-012016-12-31Us
Foltabs Prenatal Plus DHAPotassium Iodide (150 ug/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (125 mg/1) + Cholecalciferol (400 [iU]/1) + Cupric oxide (2 mg/1) + D-alpha-Tocopherol acetate (30 [iU]/1) + Doconexent (250 mg/1) + Docusate sodium (50 mg/1) + Ferrous gluconate dihydrate (13 mg/1) + Folic acid (1 mg/1) + Iron (14 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3.4 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (25 mg/1)KitMidlothian Laboratories, LLC2009-01-012011-04-30Us
Categories
UNII
1C4QK22F9J
CAS number
7681-11-0
Weight
Average: 166.0028
Monoisotopic: 165.868175281
Chemical Formula
IK
InChI Key
NLKNQRATVPKPDG-UHFFFAOYSA-M
InChI
InChI=1S/HI.K/h1H;/q;+1/p-1
IUPAC Name
potassium iodide
SMILES
[K+].[I-]

Pharmacology

Indication

Potassium Iodide is oral antithyroid agent used in the prevention of radioactive iodine uptake into the thyroid gland during a nuclear radiation emergency. Potassium Iodide may be used as an adjunct to other antithyroid agents in the treatment of hyperthyroidism and thyrotoxicosis and preoperatively to induce thyroid involution.

Associated Conditions
Pharmacodynamics

It works in the thyroid gland. By inhibiting thyroid hormone synthesis and release, thyroid gland vascularity is reduced, thyroid gland tissue becomes firmer, thyroid cell size is reduced, follicular colloid reaccumulates, and bound iodine levels increase. As a protectant following radiation exposure, KI blocks the uptake of radioactive iodine isotopes by the thyroid gland thereby minimizing the risk of radiation-induced thyroid neoplasms.

Mechanism of action
TargetActionsOrganism
UTyrosine
binder
Humans
Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic AcidThe risk or severity of hyperkalemia can be increased when Potassium Iodide is combined with 1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic Acid.
2,5-Dimethoxy-4-ethylamphetamineThe risk or severity of adverse effects can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Potassium Iodide.
2,5-Dimethoxy-4-ethylthioamphetamineThe risk or severity of adverse effects can be increased when 2,5-Dimethoxy-4-ethylthioamphetamine is combined with Potassium Iodide.
4-Bromo-2,5-dimethoxyamphetamineThe risk or severity of adverse effects can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Potassium Iodide.
AcalabrutinibThe therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Acalabrutinib.
AcebutololThe therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Acebutolol.
AceclofenacPotassium Iodide may increase the hyperkalemic activities of Aceclofenac.
AcemetacinPotassium Iodide may increase the hyperkalemic activities of Acemetacin.
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Potassium Iodide.
AdrenaloneThe therapeutic efficacy of Adrenalone can be increased when used in combination with Potassium Iodide.
Additional Data Available
  • Extended Description
    Extended Description

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  • Severity
    Severity

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  • Evidence Level
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Food Interactions
Not Available

References

Synthesis Reference

Stanley D. Lazarus, "Production of thermally stabilized polyester with alkylene carbonates and sodium or potassium iodide." U.S. Patent US4327207, issued October, 1973.

US4327207
General References
Not Available
External Links
KEGG Drug
D01016
KEGG Compound
C08219
PubChem Compound
4875
PubChem Substance
99443267
ChemSpider
4709
ChEBI
8346
ChEMBL
CHEMBL1141
PharmGKB
PA451060
Wikipedia
SSKI
ATC Codes
S01XA04 — Potassium iodideV03AB21 — Potassium iodideR05CA02 — Potassium iodide
AHFS Codes
  • 68:36.08 — Antithyroid Agents
  • 48:16.00 — Expectorants
  • 88:29.00* — Minerals

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0RecruitingTreatmentMetastatic Pheochromocytoma / Relapsed Neuroblastoma1
2CompletedTreatmentMalignant Lymphomas1
2TerminatedTreatmentNon-Hodgkin's Lymphoma (NHL)1
3CompletedPreventionCariostatic Agents / Dental Decay1
3CompletedTreatmentDental Plaque1
3TerminatedPreventionHeart Failure1
3TerminatedTreatmentPregnancy1
4CompletedDiagnosticCoronary Artery Disease / Coronary Stenosis1
4CompletedTreatmentAmputation Wound / Wound Infections1
4CompletedTreatmentGraves Diseases / Hyperthyroidism1
4CompletedTreatmentHyperemesis Gravidarum / Morning Sickness / Nausea / Pregnancy / Vomiting1
4CompletedTreatmentPregnancy1
4Not Yet RecruitingTreatmentHyperthyroidism, Autoimmune1
Not AvailableRecruitingTreatmentMetastatic Pheochromocytoma / Relapsed Neuroblastoma1
Not AvailableRecruitingTreatmentRoot Canal Disinfection1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Tablet, chewableOral
Tablet, extended releaseOral
LiquidTopical
PowderOral
TabletOral
LiquidOral
Tablet, coatedOral
CapsuleOral0.22 mg
SolutionTopical
Tablet, extended releaseOral300 mcg
TabletOral.5 mg
TinctureTopical
TabletOral130 mg/1
Tablet, effervescentOral
LiquidIntravenous
SyrupOral
Injection, solutionIntravenous
Kit
PowderNot applicable1 kg/1kg
CapsuleOral
Capsule, gelatin coatedOral
PillOral
KitOral
PowderTopical
SolutionOral1 g/1mL
TabletOral0.09 mg
TabletOral130 mg
TabletOral65 mg/1
TabletOral65 mg
SolutionOral65 mg/1mL
Capsule, liquid filledOral
Tablet, film coatedOral
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP0.2ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.7647
Blood Brain Barrier+0.9702
Caco-2 permeable+0.6625
P-glycoprotein substrateNon-substrate0.8989
P-glycoprotein inhibitor INon-inhibitor0.984
P-glycoprotein inhibitor IINon-inhibitor0.9854
Renal organic cation transporterNon-inhibitor0.9282
CYP450 2C9 substrateNon-substrate0.8261
CYP450 2D6 substrateNon-substrate0.7789
CYP450 3A4 substrateNon-substrate0.7857
CYP450 1A2 substrateNon-inhibitor0.7164
CYP450 2C9 inhibitorNon-inhibitor0.8527
CYP450 2D6 inhibitorNon-inhibitor0.9142
CYP450 2C19 inhibitorNon-inhibitor0.8842
CYP450 3A4 inhibitorNon-inhibitor0.9317
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9022
Ames testNon AMES toxic0.6838
CarcinogenicityCarcinogens 0.659
BiodegradationNot ready biodegradable0.5913
Rat acute toxicity2.9202 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9535
hERG inhibition (predictor II)Non-inhibitor0.9657
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as alkali metal iodides. These are inorganic compounds in which the largest halogen atom is Iodine, and the heaviest metal atom is an alkali metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Alkali metal salts
Sub Class
Alkali metal iodides
Direct Parent
Alkali metal iodides
Alternative Parents
Inorganic salts
Substituents
Alkali metal iodide / Inorganic salt
Molecular Framework
Not Available
External Descriptors
potassium salt (CHEBI:8346)

Targets

Kind
Small molecule
Organism
Humans
Pharmacological action
Unknown
Actions
Binder
References
  1. Pisarev MA, Aiello LO: Studies on the mechanism of action of potassium iodide on thyroid protein biosynthesis. Acta Endocrinol (Copenh). 1976 Jun;82(2):298-305. [PubMed:946922]
  2. Foldes J, Gesztesi E, Juhasz J: Mechanism of action of di-iodotyrosine and of iodine. Acta Med Acad Sci Hung. 1974;31(1-2):131-7. [PubMed:4464746]

Drug created on May 16, 2010 17:39 / Updated on July 18, 2019 19:03