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Identification
NameLevothyroxine
Accession NumberDB00451  (APRD00235, EXPT02993)
TypeSmall Molecule
GroupsApproved
DescriptionThe major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism. [PubChem]
Structure
Thumb
Synonyms
3,3',5,5'-Tetraiodo-L-thyronine
3,5,3',5'-TETRAIODO-L-thyronine
4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine
L-T4
L-Thyroxine
Levothyroxin
LT4
O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosine
O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine
T4
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
EltroxinTablet150 mcgOralAspen Pharma Trading Limited1974-12-31Not applicableCanada
EltroxinTablet200 mcgOralAspen Pharma Trading Limited1997-04-02Not applicableCanada
EltroxinTablet300 mcgOralAspen Pharma Trading Limited1998-02-11Not applicableCanada
EltroxinTablet50 mcgOralAspen Pharma Trading Limited1951-12-30Not applicableCanada
EltroxinTablet100 mcgOralAspen Pharma Trading Limited1998-11-27Not applicableCanada
Eltroxin 150 TabTablet150 mcgOralGlaxo Canada Inc1974-12-311999-08-12Canada
Eltroxin Tab 100mcgTablet.1 mgOralGlaxo Canada Inc1951-12-311999-08-12Canada
Eltroxin Tab 200mcgTablet.2 mgOralGlaxo Canada Inc1960-12-311998-07-30Canada
Eltroxin Tab 300mcgTablet.3 mgOralGlaxo Canada Inc1966-12-311998-07-30Canada
Eltroxin Tab 50mcgTablet.05 mgOralGlaxo Canada Inc1951-12-311998-07-30Canada
EuthyroxTablet50 mcgOralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
EuthyroxTablet175 mcgOralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
EuthyroxTablet112 mcgOralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
EuthyroxTablet75 mcgOralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
EuthyroxTablet200 mcgOralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
EuthyroxTablet125 mcgOralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
EuthyroxTablet88 mcgOralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
EuthyroxTablet300 mcgOralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
EuthyroxTablet137 mcgOralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
EuthyroxTablet25 mcgOralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
EuthyroxTablet100 mcgOralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
EuthyroxTablet150 mcgOralEmd Serono A Division Of Emd Inc Canada2005-05-19Not applicableCanada
Levo-TTablet137 ug/1OralNeolpharma, Inc.2015-10-29Not applicableUs
Levo-TTablet88 ug/1OralNeolpharma, Inc.2015-10-29Not applicableUs
Levo-TTablet300 ug/1OralNeolpharma, Inc.2015-10-29Not applicableUs
Levo-TTablet25 ug/1OralNeolpharma, Inc.2015-10-29Not applicableUs
Levo-TTablet150 ug/1OralNeolpharma, Inc.2015-10-29Not applicableUs
Levo-TTablet100 ug/1OralNeolpharma, Inc.2015-10-29Not applicableUs
Levo-TTablet50 ug/1OralNeolpharma, Inc.2015-10-29Not applicableUs
Levo-TTablet175 ug/1OralNeolpharma, Inc.2015-10-29Not applicableUs
Levo-TTablet112 ug/1OralNeolpharma, Inc.2015-10-29Not applicableUs
Levo-TTablet75 ug/1OralNeolpharma, Inc.2015-10-29Not applicableUs
Levo-TTablet200 ug/1OralNeolpharma, Inc.2015-10-29Not applicableUs
Levo-TTablet125 ug/1OralNeolpharma, Inc.2015-10-29Not applicableUs
Levo-T 100mcg - TabTablet100 mcgOralPharmascience Inc1996-12-312006-06-08Canada
Levo-T 125mcg - TabTablet125 mcgOralPharmascience Inc1996-12-312006-06-08Canada
Levo-T 150mcg - TabTablet150 mcgOralPharmascience Inc1996-12-312006-06-08Canada
Levo-T 200mcg - TabTablet200 mcgOralPharmascience Inc1996-12-312006-06-08Canada
Levo-T 25mcg - TabTablet25 mcgOralPharmascience Inc1996-07-302006-06-08Canada
Levo-T 300mcg - TabTablet300 mcgOralPharmascience Inc1996-12-312006-06-08Canada
Levo-T 50mcg - TabTablet50 mcgOralPharmascience Inc1996-12-312006-06-08Canada
Levo-T 75mcg - TabTablet75 mcgOralPharmascience Inc1996-06-272006-06-08Canada
Levotec 100mcg Tablets USPTablet100 mcgOralTechnilab Pharma Inc.1998-09-082004-07-22Canada
Levotec 112mcg Tablets USPTablet112 mcgOralTechnilab Pharma Inc.1998-09-082004-07-20Canada
Levotec 125mcg Tablets USPTablet125 mcgOralTechnilab Pharma Inc.1998-09-082004-07-20Canada
Levotec 150mcg Tablets USPTablet150 mcgOralTechnilab Pharma Inc.1998-09-082004-07-20Canada
Levotec 175mcg Tablets USPTablet175 mcgOralTechnilab Pharma Inc.1998-09-082004-07-20Canada
Levotec 200mcg Tablets USPTablet200 mcgOralTechnilab Pharma Inc.1998-09-082004-07-20Canada
Levotec 25mcg Tablets USPTablet25 mcgOralTechnilab Pharma Inc.1998-09-082004-07-20Canada
Levotec 300mcg Tablets USPTablet300 mcgOralTechnilab Pharma Inc.1998-09-082004-07-20Canada
Levotec 50mcg Tablets USPTablet50 mcgOralTechnilab Pharma Inc.1998-09-082004-07-20Canada
Levotec 75mcg Tablets USPTablet75 mcgOralTechnilab Pharma Inc.1998-09-082004-07-20Canada
LevothroidTablet175 ug/1OralPhysicians Total Care, Inc.2003-09-12Not applicableUs
LevothroidTablet200 ug/1OralPhysicians Total Care, Inc.2005-05-20Not applicableUs
LevothroidTablet150 ug/1OralPhysicians Total Care, Inc.2002-03-08Not applicableUs
LevothyroxineTablet25 ug/1OralNorthwind Pharmaceuticals, LLC2014-07-10Not applicableUs
LevothyroxineTablet125 ug/1OralNorthwind Pharmaceuticals, LLC2014-09-14Not applicableUs
Levothyroxine SodiumTablet.125 mg/1OralPd Rx Pharmaceuticals, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.088 mg/1OralDIRECT RX2015-12-02Not applicableUs
Levothyroxine SodiumTablet.05 mg/1OralClinical Solutions Wholesale2003-12-01Not applicableUs
Levothyroxine SodiumTablet.15 mg/1OralLannett Company, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.088 mg/1OralSt Marys Medical Park Pharmacy2013-05-16Not applicableUs
Levothyroxine SodiumTablet.1 mg/1OralREMEDYREPACK INC.2011-07-222016-10-26Us
Levothyroxine SodiumTablet.075 mg/1OralRebel Distributors Corp.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.088 mg/1OralMed Health Pharma, LLC2011-01-01Not applicableUs
Levothyroxine SodiumTablet.15 mg/1OralProficient Rx LP2003-12-01Not applicableUs
Levothyroxine SodiumTablet.112 mg/1OralNorthwind Pharmaceuticals, LLC2014-11-25Not applicableUs
Levothyroxine SodiumTablet.05 mg/1OralBlenheim Pharmacal, Inc.2012-02-13Not applicableUs
Levothyroxine SodiumTablet25 ug/1OralREMEDYREPACK INC.2013-02-192016-10-13Us
Levothyroxine SodiumTablet.112 mg/1OralPreferred Pharmaceuticals, Inc.2009-09-09Not applicableUs
Levothyroxine SodiumTablet.137 mg/1OralLannett Company, Inc.2007-10-01Not applicableUs
Levothyroxine SodiumTablet.075 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Levothyroxine SodiumTablet.137 mg/1OralDispensing Solutions, Inc.2007-10-01Not applicableUs
Levothyroxine SodiumTablet.125 mg/1OralUnit Dose Services2003-12-01Not applicableUs
Levothyroxine SodiumTablet112 ug/1OralA S Medication Solutions2002-03-01Not applicableUs
Levothyroxine SodiumTablet.025 mg/1OralLannett Company, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.2 mg/1OralClinical Solutions Wholesale2003-12-01Not applicableUs
Levothyroxine SodiumTablet.137 mg/1OralBlenheim Pharmacal, Inc.2013-11-18Not applicableUs
Levothyroxine SodiumTablet.025 mg/1OralREMEDYREPACK INC.2011-12-012016-10-13Us
Levothyroxine SodiumTablet.175 mg/1OralMed Health Pharma, LLC2011-01-01Not applicableUs
Levothyroxine SodiumTablet.125 mg/1Oralbryant ranch prepack2003-12-01Not applicableUs
Levothyroxine SodiumTablet125 ug/1OralSandoz Inc.2002-03-01Not applicableUs
Levothyroxine SodiumTablet.15 mg/1OralPreferred Pharmaceuticals, Inc.2009-09-09Not applicableUs
Levothyroxine SodiumTablet.2 mg/1OralRebel Distributors Corp.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.05 mg/1OralREMEDYREPACK INC.2011-09-272016-10-13Us
Levothyroxine SodiumTablet.112 mg/1OralREMEDYREPACK INC.2013-08-132016-10-13Us
Levothyroxine SodiumTablet.05 mg/1OralUnit Dose Services2003-12-01Not applicableUs
Levothyroxine SodiumTablet.025 mg/1OralREMEDYREPACK INC.2013-04-102016-10-13Us
Levothyroxine SodiumTablet.075 mg/1OralPd Rx Pharmaceuticals, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.2 mg/1OralUnit Dose Services2003-12-01Not applicableUs
Levothyroxine SodiumTablet.2 mg/1OralBlenheim Pharmacal, Inc.2013-11-18Not applicableUs
Levothyroxine SodiumTablet200 ug/1OralA S Medication Solutions2002-03-01Not applicableUs
Levothyroxine SodiumTablet.112 mg/1OralA S Medication Solutions2003-12-01Not applicableUs
Levothyroxine SodiumTablet.112 mg/1OralClinical Solutions Wholesale2003-12-01Not applicableUs
Levothyroxine SodiumTablet.125 mg/1OralREMEDYREPACK INC.2011-10-212016-10-28Us
Levothyroxine SodiumTablet.125 mg/1OralRebel Distributors Corp.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.15 mg/1OralMed Health Pharma, LLC2011-01-01Not applicableUs
Levothyroxine SodiumTablet.075 mg/1Oralbryant ranch prepack2003-12-01Not applicableUs
Levothyroxine SodiumTablet.137 mg/1OralNorthwind Pharmaceuticals, LLC2015-02-04Not applicableUs
Levothyroxine SodiumTablet.088 mg/1OralBlenheim Pharmacal, Inc.2013-11-18Not applicableUs
Levothyroxine SodiumTablet50 ug/1OralREMEDYREPACK INC.2013-07-082016-10-13Us
Levothyroxine SodiumTablet75 ug/1OralPreferred Pharmaceuticals, Inc.2014-10-13Not applicableUs
Levothyroxine SodiumTablet75 ug/1OralSandoz Inc.2002-03-01Not applicableUs
Levothyroxine SodiumTablet.075 mg/1OralPreferred Pharmaceuticals, Inc.2009-09-09Not applicableUs
Levothyroxine SodiumTablet112 ug/1OralLake Erie Medical DBA Quality Care Products LLC2002-03-01Not applicableUs
Levothyroxine SodiumTablet.137 mg/1OralProficient Rx LP2007-10-01Not applicableUs
Levothyroxine SodiumTablet.1 mg/1OralH.J. Harkins Company, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumInjection, powder, lyophilized, for solution500 ug/5mLIntravenousFresenius Kabi USA, LLC2011-06-24Not applicableUs
Levothyroxine SodiumTablet50 ug/1OralTYA Pharmaceuticals2002-03-01Not applicableUs
Levothyroxine SodiumTablet.1 mg/1OralLannett Company, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.025 mg/1OralSt Marys Medical Park Pharmacy2013-05-16Not applicableUs
Levothyroxine SodiumTablet.15 mg/1OralREMEDYREPACK INC.2011-07-132016-10-13Us
Levothyroxine SodiumTablet.112 mg/1OralSTAT Rx USA LLC2003-12-01Not applicableUs
Levothyroxine SodiumTablet.025 mg/1OralMed Health Pharma, LLC2011-01-01Not applicableUs
Levothyroxine SodiumTablet.1 mg/1OralProficient Rx LP2003-12-01Not applicableUs
Levothyroxine SodiumTablet.15 mg/1OralNorthwind Pharmaceuticals2014-12-17Not applicableUs
Levothyroxine SodiumTablet.137 mg/1Oralbryant ranch prepack2007-10-01Not applicableUs
Levothyroxine SodiumTablet300 ug/1OralSandoz Inc.2002-03-01Not applicableUs
Levothyroxine SodiumInjection, powder, lyophilized, for solution100 ug/5mLIntravenousPar Pharmaceutical Inc.2011-06-24Not applicableUs
Levothyroxine SodiumTablet.025 mg/1OralA S Medication Solutions2003-12-01Not applicableUs
Levothyroxine SodiumTablet.075 mg/1OralClinical Solutions Wholesale2003-12-01Not applicableUs
Levothyroxine SodiumTablet.175 mg/1OralLannett Company, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.1 mg/1OralSt Marys Medical Park Pharmacy2013-01-10Not applicableUs
Levothyroxine SodiumTablet.05 mg/1OralREMEDYREPACK INC.2011-07-282016-10-26Us
Levothyroxine SodiumTablet.088 mg/1OralRebel Distributors Corp2003-12-01Not applicableUs
Levothyroxine SodiumTablet.1 mg/1OralMed Health Pharma, LLC2011-01-01Not applicableUs
Levothyroxine SodiumTablet.025 mg/1OralProficient Rx LP2003-12-01Not applicableUs
Levothyroxine SodiumTablet.1 mg/1OralNorthwind Pharmaceuticals2014-12-17Not applicableUs
Levothyroxine SodiumTablet.025 mg/1OralBlenheim Pharmacal, Inc.2013-11-15Not applicableUs
Levothyroxine SodiumTablet100 ug/1OralREMEDYREPACK INC.2013-05-062016-10-13Us
Levothyroxine SodiumTablet.175 mg/1OralPreferred Pharmaceuticals, Inc.2009-09-09Not applicableUs
Levothyroxine SodiumTablet150 ug/1OralPreferred Pharmaceuticals Inc.2016-03-02Not applicableUs
Levothyroxine SodiumTablet.125 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Levothyroxine SodiumTablet.2 mg/1OralDispensing Solutions, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet125 ug/1OralREMEDYREPACK INC.2013-09-242016-10-13Us
Levothyroxine SodiumTablet.075 mg/1OralUnit Dose Services2003-12-01Not applicableUs
Levothyroxine SodiumTablet.2 mg/1OralA S Medication Solutions2003-12-01Not applicableUs
Levothyroxine SodiumTablet.05 mg/1OralLannett Company, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.137 mg/1OralSt Marys Medical Park Pharmacy2014-04-09Not applicableUs
Levothyroxine SodiumTablet25 ug/1OralMedsource Pharmaceuticals2002-03-01Not applicableUs
Levothyroxine SodiumTablet.15 mg/1OralBlenheim Pharmacal, Inc.2013-11-18Not applicableUs
Levothyroxine SodiumTablet.125 mg/1OralREMEDYREPACK INC.2011-12-282016-10-26Us
Levothyroxine SodiumTablet.025 mg/1Oralbryant ranch prepack2003-12-01Not applicableUs
Levothyroxine SodiumTablet150 ug/1OralSandoz Inc.2002-03-01Not applicableUs
Levothyroxine SodiumTablet.2 mg/1OralPreferred Pharmaceuticals, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet125 ug/1OralAidarex Pharmaceuticals LLC2002-03-01Not applicableUs
Levothyroxine SodiumTablet50 ug/1OralPreferred Pharmaceuticals, Inc.2014-10-13Not applicableUs
Levothyroxine SodiumTablet88 ug/1OralSandoz Inc.2002-03-01Not applicableUs
Levothyroxine SodiumTablet.025 mg/1OralREMEDYREPACK INC.2013-02-162016-10-13Us
Levothyroxine SodiumTablet.088 mg/1OralPd Rx Pharmaceuticals, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.088 mg/1OralUnit Dose Services2003-12-01Not applicableUs
Levothyroxine SodiumTablet.15 mg/1OralUnit Dose Services2003-12-01Not applicableUs
Levothyroxine SodiumTablet.05 mg/1OralA S Medication Solutions2003-12-01Not applicableUs
Levothyroxine SodiumTablet.1 mg/1OralA S Medication Solutions2003-12-01Not applicableUs
Levothyroxine SodiumTablet.125 mg/1OralClinical Solutions Wholesale2003-12-01Not applicableUs
Levothyroxine SodiumTablet.075 mg/1OralREMEDYREPACK INC.2011-12-072016-10-18Us
Levothyroxine SodiumTablet.137 mg/1OralRebel Distributors Corp2007-10-01Not applicableUs
Levothyroxine SodiumTablet.2 mg/1OralMed Health Pharma, LLC2011-01-01Not applicableUs
Levothyroxine SodiumTablet.1 mg/1Oralbryant ranch prepack2003-12-01Not applicableUs
Levothyroxine SodiumTablet.05 mg/1OralNorthwind Pharmaceuticals, LLC2014-09-03Not applicableUs
Levothyroxine SodiumTablet.1 mg/1OralBlenheim Pharmacal, Inc.2013-11-18Not applicableUs
Levothyroxine SodiumTablet112 ug/1OralREMEDYREPACK INC.2013-07-082016-10-13Us
Levothyroxine SodiumTablet137 ug/1OralSandoz Inc.2002-03-01Not applicableUs
Levothyroxine SodiumTablet.088 mg/1OralPreferred Pharmaceuticals, Inc.2009-09-09Not applicableUs
Levothyroxine SodiumTablet25 ug/1OralLake Erie Medical DBA Quality Care Products LLC2002-03-01Not applicableUs
Levothyroxine SodiumTablet.125 mg/1OralH.J. Harkins Company, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumInjection, powder, lyophilized, for solution100 ug/5mLIntravenousFresenius Kabi USA, LLC2011-06-24Not applicableUs
Levothyroxine SodiumTablet.025 mg/1OralPd Rx Pharmaceuticals, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.05 mg/1OralDIRECT RX2015-12-02Not applicableUs
Levothyroxine SodiumTablet200 ug/1OralLake Erie Medical DBA Quality Care Products LLC2002-03-01Not applicableUs
Levothyroxine SodiumTablet.112 mg/1OralLannett Company, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.05 mg/1OralSt Marys Medical Park Pharmacy2013-07-11Not applicableUs
Levothyroxine SodiumTablet.2 mg/1OralREMEDYREPACK INC.2011-07-142016-10-18Us
Levothyroxine SodiumTablet.025 mg/1OralRebel Distributors Corp.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.05 mg/1OralMed Health Pharma, LLC2011-01-01Not applicableUs
Levothyroxine SodiumTablet.112 mg/1OralProficient Rx LP2003-12-01Not applicableUs
Levothyroxine SodiumTablet.112 mg/1OralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Levothyroxine SodiumInjection, powder, lyophilized, for solution200 ug/5mLIntravenousPar Pharmaceutical Inc.2011-06-24Not applicableUs
Levothyroxine SodiumTablet.088 mg/1OralA S Medication Solutions2003-12-01Not applicableUs
Levothyroxine SodiumTablet.088 mg/1OralClinical Solutions Wholesale2003-12-01Not applicableUs
Levothyroxine SodiumTablet.2 mg/1OralLannett Company, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.112 mg/1OralSt Marys Medical Park Pharmacy2013-05-16Not applicableUs
Levothyroxine SodiumTablet.15 mg/1OralREMEDYREPACK INC.2011-08-102016-10-13Us
Levothyroxine SodiumTablet.1 mg/1OralRebel Distributors Corp.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.112 mg/1OralMed Health Pharma, LLC2011-01-01Not applicableUs
Levothyroxine SodiumTablet.088 mg/1OralProficient Rx LP2003-12-01Not applicableUs
Levothyroxine SodiumTablet.137 mg/1OralNorthwind Pharmaceuticals2014-12-23Not applicableUs
Levothyroxine SodiumTablet.05 mg/1OralBlenheim Pharmacal, Inc.2013-11-15Not applicableUs
Levothyroxine SodiumTablet.088 mg/1OralREMEDYREPACK INC.2013-08-272016-10-13Us
Levothyroxine SodiumTablet25 ug/1OralPreferred Pharmaceuticals, Inc.2014-10-13Not applicableUs
Levothyroxine SodiumTablet25 ug/1OralSandoz Inc.2002-03-01Not applicableUs
Levothyroxine SodiumTablet.1 mg/1OralPd Rx Pharmaceuticals, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet150 ug/1OralREMEDYREPACK INC.2013-11-012016-10-13Us
Levothyroxine SodiumTablet.137 mg/1OralUnit Dose Services2007-10-01Not applicableUs
Levothyroxine SodiumTablet.088 mg/1OralA S Medication Solutions2003-12-01Not applicableUs
Levothyroxine SodiumTablet.075 mg/1OralLannett Company, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.15 mg/1OralSt Marys Medical Park Pharmacy2013-07-11Not applicableUs
Levothyroxine SodiumTablet50 ug/1OralMedsource Pharmaceuticals2002-03-01Not applicableUs
Levothyroxine SodiumTablet.1 mg/1OralSTAT Rx USA LLC2003-12-01Not applicableUs
Levothyroxine SodiumTablet75 ug/1OralREMEDYREPACK INC.2013-02-152016-10-13Us
Levothyroxine SodiumTablet.088 mg/1OralNorthwind Pharmaceuticals, LLC2014-07-31Not applicableUs
Levothyroxine SodiumTablet.112 mg/1Oralbryant ranch prepack2003-12-01Not applicableUs
Levothyroxine SodiumTablet175 ug/1OralSandoz Inc.2002-03-01Not applicableUs
Levothyroxine SodiumTablet.025 mg/1OralPreferred Pharmaceuticals, Inc.2009-09-09Not applicableUs
Levothyroxine SodiumTablet.137 mg/1OralLake Erie Medical DBA Quality Care Products LLC2007-10-01Not applicableUs
Levothyroxine SodiumTablet.2 mg/1Oralbryant ranch prepack2003-12-01Not applicableUs
Levothyroxine SodiumTablet.112 mg/1OralBlenheim Pharmacal, Inc.2013-11-18Not applicableUs
Levothyroxine SodiumTablet.025 mg/1OralREMEDYREPACK INC.2013-08-132016-10-13Us
Levothyroxine SodiumTablet100 ug/1OralSandoz Inc.2002-03-01Not applicableUs
Levothyroxine SodiumTablet.075 mg/1OralREMEDYREPACK INC.2013-08-272016-10-13Us
Levothyroxine SodiumTablet.112 mg/1OralPd Rx Pharmaceuticals, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.112 mg/1OralUnit Dose Services2003-12-01Not applicableUs
Levothyroxine SodiumTablet50 ug/1OralA S Medication Solutions2002-03-01Not applicableUs
Levothyroxine SodiumTablet.175 mg/1OralA S Medication Solutions2003-12-01Not applicableUs
Levothyroxine SodiumTablet.15 mg/1OralClinical Solutions Wholesale2003-12-01Not applicableUs
Levothyroxine SodiumTablet.137 mg/1OralREMEDYREPACK INC.2011-12-082016-10-26Us
Levothyroxine SodiumTablet.15 mg/1OralRebel Distributors Corp.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.3 mg/1OralMed Health Pharma, LLC2011-01-01Not applicableUs
Levothyroxine SodiumTablet.05 mg/1OralRebel Distributors Corp.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.075 mg/1OralMed Health Pharma, LLC2011-01-01Not applicableUs
Levothyroxine SodiumTablet.075 mg/1OralProficient Rx LP2003-12-01Not applicableUs
Levothyroxine SodiumTablet.1 mg/1OralNorthwind Pharmaceuticals, LLC2014-11-03Not applicableUs
Levothyroxine SodiumTablet.075 mg/1OralBlenheim Pharmacal, Inc.2010-12-20Not applicableUs
Levothyroxine SodiumTablet.1 mg/1OralPreferred Pharmaceuticals, Inc.2009-09-09Not applicableUs
Levothyroxine SodiumTablet88 ug/1OralLake Erie Medical DBA Quality Care Products LLC2002-03-01Not applicableUs
Levothyroxine SodiumTablet.175 mg/1OralProficient Rx LP2003-12-01Not applicableUs
Levothyroxine SodiumTablet.05 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Levothyroxine SodiumTablet.112 mg/1OralDispensing Solutions, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.1 mg/1OralUnit Dose Services2003-12-01Not applicableUs
Levothyroxine SodiumTablet.2 mg/1OralPd Rx Pharmaceuticals, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.025 mg/1OralDIRECT RX2015-12-02Not applicableUs
Levothyroxine SodiumTablet.025 mg/1OralClinical Solutions Wholesale2003-12-01Not applicableUs
Levothyroxine SodiumTablet.125 mg/1OralLannett Company, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.075 mg/1OralSt Marys Medical Park Pharmacy2013-07-11Not applicableUs
Levothyroxine SodiumTablet.125 mg/1OralREMEDYREPACK INC.2011-07-152016-10-13Us
Levothyroxine SodiumTablet100 ug/1OralPreferred Pharmaceuticals Inc.2016-03-14Not applicableUs
Levothyroxine SodiumTablet.125 mg/1OralREMEDYREPACK INC.2011-11-012016-10-13Us
Levothyroxine SodiumInjection, powder, lyophilized, for solution500 ug/5mLIntravenousPar Pharmaceutical Inc.2011-06-24Not applicableUs
Levothyroxine SodiumTablet.137 mg/1OralA S Medication Solutions2007-10-01Not applicableUs
Levothyroxine SodiumTablet.1 mg/1OralClinical Solutions Wholesale2003-12-01Not applicableUs
Levothyroxine SodiumTablet.3 mg/1OralLannett Company, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.025 mg/1OralREMEDYREPACK INC.2011-08-102016-10-26Us
Levothyroxine SodiumTablet.112 mg/1OralRebel Distributors Corp2003-12-01Not applicableUs
Levothyroxine SodiumTablet.137 mg/1OralMed Health Pharma, LLC2011-01-01Not applicableUs
Levothyroxine SodiumTablet88 ug/1Oralbryant ranch prepack2011-05-01Not applicableUs
Levothyroxine SodiumTablet.2 mg/1OralNorthwind Pharmaceuticals, LLC2015-02-03Not applicableUs
Levothyroxine SodiumTablet.175 mg/1OralDispensing Solutions, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.075 mg/1OralBlenheim Pharmacal, Inc.2013-11-18Not applicableUs
Levothyroxine SodiumTablet.15 mg/1OralREMEDYREPACK INC.2013-08-132016-10-13Us
Levothyroxine SodiumTablet125 ug/1OralPreferred Pharmaceuticals, Inc.2014-10-13Not applicableUs
Levothyroxine SodiumTablet50 ug/1OralSandoz Inc.2002-03-01Not applicableUs
Levothyroxine SodiumTablet.15 mg/1OralPd Rx Pharmaceuticals, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.05 mg/1OralLake Erie Medical DBA Quality Care Products LLC2003-12-01Not applicableUs
Levothyroxine SodiumTablet.125 mg/1OralProficient Rx LP2003-12-01Not applicableUs
Levothyroxine SodiumTablet.175 mg/1OralREMEDYREPACK INC.2014-02-032016-10-21Us
Levothyroxine SodiumInjection, powder, lyophilized, for solution200 ug/5mLIntravenousFresenius Kabi USA, LLC2011-06-24Not applicableUs
Levothyroxine SodiumTablet.05 mg/1OralTYA Pharmaceuticals2003-12-01Not applicableUs
Levothyroxine SodiumTablet.088 mg/1OralLannett Company, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.125 mg/1OralSt Marys Medical Park Pharmacy2013-05-16Not applicableUs
Levothyroxine SodiumTablet.137 mg/1OralREMEDYREPACK INC.2011-07-142016-10-13Us
Levothyroxine SodiumTablet.05 mg/1OralSTAT Rx USA LLC2003-12-01Not applicableUs
Levothyroxine SodiumTablet175 ug/1OralLake Erie Medical DBA Quality Care Products LLC2002-03-01Not applicableUs
Levothyroxine SodiumTablet.05 mg/1OralProficient Rx LP2003-12-01Not applicableUs
Levothyroxine SodiumTablet.075 mg/1OralNorthwind Pharmaceuticals, LLC2014-10-21Not applicableUs
Levothyroxine SodiumTablet.175 mg/1Oralbryant ranch prepack2003-12-01Not applicableUs
Levothyroxine SodiumTablet200 ug/1OralSandoz Inc.2002-03-01Not applicableUs
Levothyroxine SodiumTablet.05 mg/1OralPreferred Pharmaceuticals, Inc.2009-09-09Not applicableUs
Levothyroxine SodiumTablet.05 mg/1OralREMEDYREPACK INC.2011-10-312016-10-13Us
Levothyroxine SodiumTablet.175 mg/1OralRebel Distributors Corp2003-12-01Not applicableUs
Levothyroxine SodiumTablet.125 mg/1OralMed Health Pharma, LLC2011-01-01Not applicableUs
Levothyroxine SodiumTablet.05 mg/1Oralbryant ranch prepack2003-12-01Not applicableUs
Levothyroxine SodiumTablet150 ug/1OralDispensing Solutions, Inc.2011-05-01Not applicableUs
Levothyroxine SodiumTablet.125 mg/1OralBlenheim Pharmacal, Inc.2013-11-18Not applicableUs
Levothyroxine SodiumTablet.075 mg/1OralREMEDYREPACK INC.2013-08-13Not applicableUs
Levothyroxine SodiumTablet.125 mg/1OralPreferred Pharmaceuticals, Inc.2009-09-09Not applicableUs
Levothyroxine SodiumTablet112 ug/1OralSandoz Inc.2002-03-01Not applicableUs
Levothyroxine SodiumTablet.1 mg/1OralREMEDYREPACK INC.2013-02-142016-10-13Us
Levothyroxine SodiumTablet.05 mg/1OralPd Rx Pharmaceuticals, Inc.2003-12-01Not applicableUs
Levothyroxine SodiumTablet.025 mg/1OralUnit Dose Services2003-12-01Not applicableUs
Levothyroxine SodiumTablet150 ug/1OralA S Medication Solutions2002-03-01Not applicableUs
Levothyroxine SodiumTablet.2 mg/1OralA S Medication Solutions2003-12-01Not applicableUs
Levothyroxine SodiumTablet.2 mg/1OralClinical Solutions Wholesale2003-12-01Not applicableUs
Levothyroxine Sodium for InjectionPowder, for solution200 mcgIntramuscular; IntravenousFresenius Kabi Canada LtdNot applicableNot applicableCanada
Levothyroxine Sodium for InjectionPowder, for solution500 mcgIntramuscular; IntravenousFresenius Kabi Canada Ltd2002-08-27Not applicableCanada
LevoxylTablet75 ug/1OralPhysicians Total Care, Inc.2001-08-03Not applicableUs
LevoxylTablet125 ug/1OralCardinal Health2001-05-252016-10-13Us
LevoxylTablet112 ug/1OralPfizer Laboratories Div Pfizer Inc2001-05-25Not applicableUs
LevoxylTablet50 ug/1OralCardinal Health2001-05-252016-10-13Us
LevoxylTablet50 ug/1OralPfizer Laboratories Div Pfizer Inc2001-05-25Not applicableUs
LevoxylTablet50 ug/1OralPhysicians Total Care, Inc.2002-11-15Not applicableUs
LevoxylTablet200 ug/1OralCardinal Health2001-05-252016-10-13Us
LevoxylTablet175 ug/1OralPfizer Laboratories Div Pfizer Inc2001-05-25Not applicableUs
LevoxylTablet150 ug/1OralPhysicians Total Care, Inc.2001-08-22Not applicableUs
LevoxylTablet137 ug/1OralCardinal Health2001-05-252016-10-13Us
LevoxylTablet125 ug/1OralPfizer Laboratories Div Pfizer Inc2001-05-25Not applicableUs
LevoxylTablet75 ug/1OralCardinal Health2001-05-252016-10-13Us
LevoxylTablet75 ug/1OralPfizer Laboratories Div Pfizer Inc2001-05-25Not applicableUs
LevoxylTablet50 ug/1OralDispensing Solutions, Inc.2001-05-25Not applicableUs
LevoxylTablet100 ug/1OralPhysicians Total Care, Inc.2001-08-03Not applicableUs
LevoxylTablet200 ug/1OralPfizer Laboratories Div Pfizer Inc2001-05-25Not applicableUs
LevoxylTablet125 ug/1OralPhysicians Total Care, Inc.2001-12-11Not applicableUs
LevoxylTablet25 ug/1OralCardinal Health2001-05-252016-10-13Us
LevoxylTablet112 ug/1OralPhysicians Total Care, Inc.1996-08-29Not applicableUs
LevoxylTablet150 ug/1OralCardinal Health2001-05-252016-10-13Us
LevoxylTablet137 ug/1OralPfizer Laboratories Div Pfizer Inc2001-05-25Not applicableUs
LevoxylTablet100 ug/1OralDispensing Solutions, Inc.2001-05-25Not applicableUs
LevoxylTablet88 ug/1OralCardinal Health2001-05-252016-10-13Us
LevoxylTablet88 ug/1OralPfizer Laboratories Div Pfizer Inc2001-05-25Not applicableUs
LevoxylTablet88 ug/1OralPhysicians Total Care, Inc.2000-05-10Not applicableUs
LevoxylTablet100 ug/1OralCardinal Health2001-05-252016-10-13Us
LevoxylTablet25 ug/1OralPfizer Laboratories Div Pfizer Inc2001-05-25Not applicableUs
LevoxylTablet25 ug/1OralPhysicians Total Care, Inc.2003-06-20Not applicableUs
LevoxylTablet175 ug/1OralCardinal Health2001-05-252016-10-13Us
LevoxylTablet150 ug/1OralPfizer Laboratories Div Pfizer Inc2001-05-25Not applicableUs
LevoxylTablet100 ug/1OralPfizer Laboratories Div Pfizer Inc2001-05-25Not applicableUs
LevoxylTablet112 ug/1OralCardinal Health2001-05-252016-10-13Us
PMS-levothyroxine Sodium Tab 100mcgTablet100 mcgOralPharmascience Inc1993-12-311998-08-07Canada
PMS-levothyroxine Sodium Tab 125mcgTablet125 mcgOralPharmascience Inc1993-12-311998-08-07Canada
PMS-levothyroxine Sodium Tab 150mcgTablet150 mcgOralPharmascience Inc1993-12-311998-08-07Canada
PMS-levothyroxine Sodium Tab 200mcgTablet200 mcgOralPharmascience Inc1993-12-311998-08-07Canada
PMS-levothyroxine Sodium Tab 25mcgTablet25 mcgOralPharmascience Inc1993-12-311998-08-07Canada
PMS-levothyroxine Sodium Tab 300mcgTablet300 mcgOralPharmascience Inc1993-12-311998-08-07Canada
PMS-levothyroxine Sodium Tab 50mcgTablet50 mcgOralPharmascience Inc1993-12-311998-08-07Canada
PMS-levothyroxine Sodium Tab 75mcgTablet75 mcgOralPharmascience Inc1993-12-311998-08-07Canada
SynthroidTablet88 ug/1OralDispensing Solutions, Inc.2002-07-24Not applicableUs
SynthroidTablet150 ug/1OralAphena Pharma Solutions Tennessee, Inc.2002-07-24Not applicableUs
SynthroidTablet150 ug/1OralPd Rx Pharmaceuticals, Inc.2002-07-24Not applicableUs
SynthroidTablet112 ug/1OralAvera Mc Kennan Hospital2015-03-09Not applicableUs
SynthroidTablet137 mcgOralBgp Pharma Ulc2003-11-01Not applicableCanada
SynthroidTablet88 ug/1OralCardinal Health2002-07-242016-10-13Us
SynthroidTablet150 ug/1OralCardinal Health2002-07-242016-10-13Us
SynthroidTablet125 ug/1OralAbb Vie Inc.2002-07-24Not applicableUs
SynthroidTablet137 ug/1OralAphena Pharma Solutions Tennessee, Inc.2002-07-24Not applicableUs
SynthroidTablet25 ug/1OralREMEDYREPACK INC.2013-02-22Not applicableUs
SynthroidTablet175 ug/1OralAphena Pharma Solutions Tennessee, Inc.2002-07-24Not applicableUs
SynthroidTablet137 ug/1OralAvera Mc Kennan Hospital2015-03-10Not applicableUs
SynthroidTablet150 ug/1OralA S Medication Solutions Llc2002-07-24Not applicableUs
SynthroidTablet125 mcgOralBgp Pharma Ulc1996-12-31Not applicableCanada
SynthroidTablet100 ug/1OralState of Florida DOH Central Pharmacy2014-11-01Not applicableUs
SynthroidTablet50 ug/1OralAbb Vie Inc.2002-07-24Not applicableUs
SynthroidTablet150 ug/1OralDispensing Solutions, Inc.2002-07-24Not applicableUs
SynthroidTablet88 ug/1OralDispensing Solutions, Inc.2002-07-24Not applicableUs
SynthroidTablet88 mcgOralBgp Pharma Ulc1996-12-31Not applicableCanada
SynthroidTablet125 ug/1OralCardinal Health2002-07-242016-10-13Us
SynthroidTablet300 ug/1OralAbb Vie Inc.2002-07-24Not applicableUs
SynthroidTablet88 ug/1OralREMEDYREPACK INC.2013-03-29Not applicableUs
SynthroidTablet88 ug/1OralAphena Pharma Solutions Tennessee, Inc.2002-07-24Not applicableUs
SynthroidTablet300 mcgOralBgp Pharma Ulc1996-12-31Not applicableCanada
SynthroidTablet175 ug/1OralCardinal Health2002-07-242016-10-13Us
SynthroidTablet50 ug/1OralDispensing Solutions, Inc.2002-07-24Not applicableUs
SynthroidTablet200 ug/1OralAphena Pharma Solutions Tennessee, Inc.2002-02-24Not applicableUs
SynthroidTablet125 ug/1OralPd Rx Pharmaceuticals, Inc.2002-07-24Not applicableUs
SynthroidTablet125 ug/1OralPhysicians Total Care, Inc.2004-06-03Not applicableUs
SynthroidTablet75 mcgOralBgp Pharma Ulc1996-12-31Not applicableCanada
SynthroidTablet100 ug/1OralCardinal Health2002-07-242016-10-13Us
SynthroidTablet150 ug/1OralAbb Vie Inc.2002-07-24Not applicableUs
SynthroidTablet137 ug/1OralREMEDYREPACK INC.2013-02-20Not applicableUs
SynthroidTablet25 ug/1OralAphena Pharma Solutions Tennessee, Inc.2002-07-24Not applicableUs
SynthroidTablet25 ug/1OralAvera Mc Kennan Hospital2015-03-09Not applicableUs
SynthroidTablet75 ug/1OralDispensing Solutions, Inc.2002-07-24Not applicableUs
SynthroidTablet75 ug/1OralA S Medication Solutions Llc2002-07-24Not applicableUs
SynthroidTablet75 ug/1OralAbb Vie Inc.2002-07-24Not applicableUs
SynthroidTablet25 ug/1OralDispensing Solutions, Inc.2002-07-24Not applicableUs
SynthroidTablet50 ug/1OralREMEDYREPACK INC.2013-04-10Not applicableUs
SynthroidTablet100 ug/1OralAphena Pharma Solutions Tennessee, Inc.2002-07-24Not applicableUs
SynthroidTablet175 ug/1OralAvera Mc Kennan Hospital2015-04-03Not applicableUs
SynthroidTablet175 mcgOralBgp Pharma Ulc1996-12-31Not applicableCanada
SynthroidTablet25 ug/1OralCardinal Health2002-07-242016-10-13Us
SynthroidTablet112 ug/1OralAbb Vie Inc.2002-07-24Not applicableUs
SynthroidTablet112 mcgOralBgp Pharma Ulc1996-12-31Not applicableCanada
SynthroidTablet137 ug/1OralAbb Vie Inc.2002-07-24Not applicableUs
SynthroidTablet100 ug/1OralDispensing Solutions, Inc.2002-07-24Not applicableUs
SynthroidTablet112 ug/1OralAphena Pharma Solutions Tennessee, Inc.2002-07-24Not applicableUs
SynthroidTablet200 mcgOralBgp Pharma Ulc1996-12-31Not applicableCanada
SynthroidTablet200 ug/1OralCardinal Health2002-02-242016-10-13Us
SynthroidTablet175 ug/1OralAbb Vie Inc.2002-07-24Not applicableUs
SynthroidTablet100 ug/1OralREMEDYREPACK INC.2012-09-27Not applicableUs
SynthroidTablet50 ug/1OralAphena Pharma Solutions Tennessee, Inc.2002-07-24Not applicableUs
SynthroidTablet125 ug/1OralREMEDYREPACK INC.2013-04-10Not applicableUs
SynthroidTablet25 ug/1OralDispensing Solutions, Inc.2002-07-24Not applicableUs
SynthroidTablet88 ug/1OralAvera Mc Kennan Hospital2015-03-17Not applicableUs
SynthroidTablet50 ug/1OralA S Medication Solutions Llc2002-07-24Not applicableUs
SynthroidTablet50 mcgOralBgp Pharma Ulc1996-12-31Not applicableCanada
SynthroidTablet50 ug/1OralCardinal Health2002-07-242016-10-13Us
SynthroidTablet88 ug/1OralAbb Vie Inc.2002-07-24Not applicableUs
SynthroidTablet75 ug/1OralDispensing Solutions, Inc.2002-07-24Not applicableUs
SynthroidTablet150 ug/1OralREMEDYREPACK INC.2013-02-27Not applicableUs
SynthroidTablet125 ug/1OralAphena Pharma Solutions Tennessee, Inc.2002-07-24Not applicableUs
SynthroidTablet100 mcgOralBgp Pharma Ulc1996-12-31Not applicableCanada
SynthroidTablet112 ug/1OralCardinal Health2002-07-242016-10-13Us
SynthroidTablet75 ug/1OralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
SynthroidTablet25 ug/1OralAbb Vie Inc.2002-07-24Not applicableUs
SynthroidTablet50 ug/1OralDispensing Solutions, Inc.2002-07-24Not applicableUs
SynthroidTablet150 mcgOralBgp Pharma Ulc1996-12-31Not applicableCanada
SynthroidTablet300 ug/1OralCardinal Health2002-07-242016-10-13Us
SynthroidTablet200 ug/1OralAbb Vie Inc.2002-02-24Not applicableUs
SynthroidTablet200 ug/1OralREMEDYREPACK INC.2012-09-27Not applicableUs
SynthroidTablet75 ug/1OralAphena Pharma Solutions Tennessee, Inc.2002-07-24Not applicableUs
SynthroidTablet75 ug/1OralREMEDYREPACK INC.2013-02-22Not applicableUs
SynthroidTablet150 ug/1OralAvera Mc Kennan Hospital2015-09-11Not applicableUs
SynthroidTablet100 ug/1OralA S Medication Solutions Llc2002-07-24Not applicableUs
SynthroidTablet25 mcgOralBgp Pharma Ulc1996-12-31Not applicableCanada
SynthroidTablet75 ug/1OralCardinal Health2002-07-242016-10-13Us
SynthroidTablet100 ug/1OralAbb Vie Inc.2002-07-24Not applicableUs
Synthroid Liq Inj 500mcg/vial USPLiquid500 mcgIntravenousBoots Pharmaceuticals Ltd.1957-12-311996-09-09Canada
Synthroid Tab 100mcg USPTablet100 mcgOralBoots Pharmaceuticals Ltd.1993-12-311996-09-09Canada
Synthroid Tab 112mcg USPTablet112 mcgOralBoots Pharmaceuticals Ltd.1993-12-311996-09-09Canada
Synthroid Tab 125mcg USPTablet125 mcgOralBoots Pharmaceuticals Ltd.1993-12-311996-09-09Canada
Synthroid Tab 150mcg USPTablet150 mcgOralBoots Pharmaceuticals Ltd.1993-12-311996-09-09Canada
Synthroid Tab 175mcg USPTablet175 mcgOralBoots Pharmaceuticals Ltd.1993-12-311996-09-09Canada
Synthroid Tab 200mcg USPTablet200 mcgOralBoots Pharmaceuticals Ltd.1993-12-311996-09-09Canada
Synthroid Tab 25mcg USPTablet25 mcgOralBoots Pharmaceuticals Ltd.1993-12-311996-09-09Canada
Synthroid Tab 300mcg TabTablet300 mcgOralBoots Pharmaceuticals Ltd.1993-12-311996-09-09Canada
Synthroid Tab 50mcg USPTablet50 mcgOralBoots Pharmaceuticals Ltd.1957-12-311996-09-09Canada
Synthroid Tab 75mcg USPTablet75 mcgOralBoots Pharmaceuticals Ltd.1993-12-311996-09-09Canada
Synthroid Tab 88mcg USPTablet88 mcgOralBoots Pharmaceuticals Ltd.1993-12-311996-09-09Canada
TirosintCapsule112 ug/1OralAkrimax Pharmaceuticals, LLC2010-04-01Not applicableUs
TirosintCapsule75 ug/1OralAkrimax Pharmaceuticals, LLC2010-04-01Not applicableUs
TirosintCapsule125 ug/1OralAkrimax Pharmaceuticals, LLC2010-04-01Not applicableUs
TirosintCapsule13 ug/1OralAkrimax Pharmaceuticals, LLC2010-04-01Not applicableUs
TirosintCapsule88 ug/1OralAkrimax Pharmaceuticals, LLC2010-04-01Not applicableUs
TirosintCapsule137 ug/1OralAkrimax Pharmaceuticals, LLC2010-04-01Not applicableUs
TirosintCapsule25 ug/1OralAkrimax Pharmaceuticals, LLC2010-04-01Not applicableUs
TirosintCapsule100 ug/1OralAkrimax Pharmaceuticals, LLC2010-04-01Not applicableUs
TirosintCapsule150 ug/1OralAkrimax Pharmaceuticals, LLC2010-04-01Not applicableUs
TirosintCapsule50 ug/1OralAkrimax Pharmaceuticals, LLC2010-04-01Not applicableUs
UnithroidTablet50 ug/1OralGemini Laboratories, LLC2014-07-03Not applicableUs
UnithroidTablet175 ug/1OralGemini Laboratories, LLC2014-07-03Not applicableUs
UnithroidTablet.1 mg/1OralLannett Company, Inc.2000-08-21Not applicableUs
UnithroidTablet.025 mg/1OralLannett Company, Inc.2000-08-21Not applicableUs
UnithroidTablet112 ug/1OralGemini Laboratories, LLC2014-07-03Not applicableUs
UnithroidTablet.175 mg/1OralLannett Company, Inc.2000-08-21Not applicableUs
UnithroidTablet75 ug/1OralGemini Laboratories, LLC2014-07-03Not applicableUs
UnithroidTablet.137 mg/1OralLannett Company, Inc.2007-10-01Not applicableUs
UnithroidTablet200 ug/1OralGemini Laboratories, LLC2014-07-03Not applicableUs
UnithroidTablet.112 mg/1OralLannett Company, Inc.2000-08-21Not applicableUs
UnithroidTablet.05 mg/1OralLannett Company, Inc.2000-08-21Not applicableUs
UnithroidTablet125 ug/1OralGemini Laboratories, LLC2014-07-03Not applicableUs
UnithroidTablet.2 mg/1OralLannett Company, Inc.2000-08-21Not applicableUs
UnithroidTablet88 ug/1OralGemini Laboratories, LLC2014-07-03Not applicableUs
UnithroidTablet300 ug/1OralGemini Laboratories, LLC2014-07-03Not applicableUs
UnithroidTablet.125 mg/1OralLannett Company, Inc.2000-08-21Not applicableUs
UnithroidTablet.075 mg/1OralLannett Company, Inc.2000-08-21Not applicableUs
UnithroidTablet137 ug/1OralGemini Laboratories, LLC2014-07-03Not applicableUs
UnithroidTablet25 ug/1OralGemini Laboratories, LLC2014-07-03Not applicableUs
UnithroidTablet.3 mg/1OralLannett Company, Inc.2000-08-21Not applicableUs
UnithroidTablet100 ug/1OralGemini Laboratories, LLC2014-07-03Not applicableUs
UnithroidTablet.15 mg/1OralLannett Company, Inc.2000-08-21Not applicableUs
UnithroidTablet.088 mg/1OralLannett Company, Inc.2000-08-21Not applicableUs
UnithroidTablet150 ug/1OralGemini Laboratories, LLC2014-07-03Not applicableUs
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Levothyroxine SodiumTablet.2 mg/1OralREMEDYREPACK INC.2011-01-262016-10-21Us
Levothyroxine SodiumTablet.15 mg/1OralPhysicians Total Care, Inc.1996-09-24Not applicableUs
Levothyroxine SodiumTablet200 ug/1OralMylan Pharmaceuticals Inc.2002-11-01Not applicableUs
Levothyroxine SodiumTablet75 ug/1OralPd Rx Pharmaceuticals, Inc.2010-01-18Not applicableUs
Levothyroxine SodiumTablet25 ug/1OralREMEDYREPACK INC.2013-08-132016-10-13Us
Levothyroxine SodiumTablet88 ug/1OralPd Rx Pharmaceuticals, Inc.2010-01-18Not applicableUs
Levothyroxine SodiumTablet125 ug/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Levothyroxine SodiumTablet75 ug/1OralMylan Pharmaceuticals Inc.2002-11-01Not applicableUs
Levothyroxine SodiumTablet112 ug/1OralPhysicians Total Care, Inc.2010-01-14Not applicableUs
Levothyroxine SodiumTablet75 ug/1OralMylan Institutional Inc.2007-02-05Not applicableUs
Levothyroxine SodiumTablet.112 mg/1OralREMEDYREPACK INC.2011-06-222016-10-13Us
Levothyroxine SodiumTablet25 ug/1OralPhysicians Total Care, Inc.2005-04-04Not applicableUs
Levothyroxine SodiumTablet100 ug/1OralA S Medication Solutions2002-11-01Not applicableUs
Levothyroxine SodiumTablet100 ug/1OralPreferred Pharmaceuticals, Inc.2015-04-21Not applicableUs
Levothyroxine SodiumTablet50 ug/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Levothyroxine SodiumTablet150 ug/1OralMylan Institutional Inc.2007-02-26Not applicableUs
Levothyroxine SodiumTablet.125 mg/1OralREMEDYREPACK INC.2010-10-202016-10-21Us
Levothyroxine SodiumTablet100 ug/1OralPhysicians Total Care, Inc.2007-09-17Not applicableUs
Levothyroxine SodiumTablet125 ug/1OralMylan Pharmaceuticals Inc.2002-11-01Not applicableUs
Levothyroxine SodiumTablet50 ug/1OralCardinal Health2010-10-29Not applicableUs
Levothyroxine SodiumTablet.15 mg/1OralREMEDYREPACK INC.2011-03-082016-10-21Us
Levothyroxine SodiumTablet50 ug/1OralPhysicians Total Care, Inc.2005-03-09Not applicableUs
Levothyroxine SodiumTablet300 ug/1OralMylan Pharmaceuticals Inc.2002-11-01Not applicableUs
Levothyroxine SodiumTablet150 ug/1OralPd Rx Pharmaceuticals, Inc.2012-08-08Not applicableUs
Levothyroxine SodiumTablet75 ug/1OralREMEDYREPACK INC.2014-01-092016-10-13Us
Levothyroxine SodiumTablet112 ug/1OralPd Rx Pharmaceuticals, Inc.2010-01-18Not applicableUs
Levothyroxine SodiumTablet150 ug/1OralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Levothyroxine SodiumTablet88 ug/1OralMylan Pharmaceuticals Inc.2002-11-01Not applicableUs
Levothyroxine SodiumTablet125 ug/1OralCardinal Health2010-10-29Not applicableUs
Levothyroxine SodiumTablet100 ug/1OralMylan Institutional Inc.2007-02-05Not applicableUs
Levothyroxine SodiumTablet175 ug/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Levothyroxine SodiumTablet.075 mg/1OralREMEDYREPACK INC.2011-06-272016-10-13Us
Levothyroxine SodiumTablet.125 mg/1OralPhysicians Total Care, Inc.1994-10-06Not applicableUs
Levothyroxine SodiumTablet.05 mg/1OralClinical Solutions Wholesale, Llc2016-06-29Not applicableUs
Levothyroxine SodiumInjection, powder, lyophilized, for solution200 ug/5mLIntravenousPar Pharmaceutical Companies, Inc.2015-12-11Not applicableUs
Levothyroxine SodiumTablet100 ug/1OralCardinal Health2010-10-29Not applicableUs
Levothyroxine SodiumTablet.025 mg/1OralNorthwind Pharmaceuticals, LLC2014-10-08Not applicableUs
Levothyroxine SodiumTablet.075 mg/1OralREMEDYREPACK INC.2010-12-082016-10-13Us
Levothyroxine SodiumTablet.2 mg/1OralPhysicians Total Care, Inc.1995-08-07Not applicableUs
Levothyroxine SodiumTablet150 ug/1OralMylan Pharmaceuticals Inc.2002-11-01Not applicableUs
Levothyroxine SodiumTablet.05 mg/1OralREMEDYREPACK INC.2011-05-032016-10-21Us
Levothyroxine SodiumTablet.3 mg/1OralPhysicians Total Care, Inc.2000-12-05Not applicableUs
Levothyroxine SodiumTablet137 ug/1OralMylan Pharmaceuticals Inc.2006-12-15Not applicableUs
Levothyroxine SodiumTablet50 ug/1OralPd Rx Pharmaceuticals, Inc.2010-01-18Not applicableUs
Levothyroxine SodiumTablet25 ug/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Levothyroxine SodiumTablet175 ug/1OralPd Rx Pharmaceuticals, Inc.2010-01-18Not applicableUs
Levothyroxine SodiumTablet125 ug/1OralState of Florida DOH Central Pharmacy2014-01-01Not applicableUs
Levothyroxine SodiumTablet100 ug/1OralMylan Pharmaceuticals Inc.2002-11-01Not applicableUs
Levothyroxine SodiumTablet150 ug/1OralCardinal Health2010-10-29Not applicableUs
Levothyroxine SodiumTablet125 ug/1OralMylan Institutional Inc.2007-02-05Not applicableUs
Levothyroxine SodiumTablet25 ug/1OralMylan Pharmaceuticals Inc.2002-11-01Not applicableUs
Levothyroxine SodiumTablet75 ug/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Levothyroxine SodiumTablet.1 mg/1OralREMEDYREPACK INC.2011-05-232016-10-13Us
Levothyroxine SodiumTablet.175 mg/1OralPhysicians Total Care, Inc.2001-04-16Not applicableUs
Levothyroxine SodiumTablet175 ug/1OralA S Medication Solutions2002-11-01Not applicableUs
Levothyroxine SodiumTablet175 ug/1OralMylan Pharmaceuticals Inc.2002-11-01Not applicableUs
Levothyroxine SodiumTablet75 ug/1OralCardinal Health2010-10-29Not applicableUs
Levothyroxine SodiumTablet88 ug/1OralREMEDYREPACK INC.2013-07-052016-10-13Us
Levothyroxine SodiumTablet.025 mg/1OralREMEDYREPACK INC.2011-01-252016-10-13Us
Levothyroxine SodiumTablet88 ug/1OralPhysicians Total Care, Inc.2008-10-24Not applicableUs
Levothyroxine SodiumTablet.137 mg/1OralREMEDYREPACK INC.2011-03-292016-10-13Us
Levothyroxine SodiumTablet75 ug/1OralPhysicians Total Care, Inc.1995-08-10Not applicableUs
Levothyroxine SodiumTablet50 ug/1OralA S Medication Solutions2002-11-012016-10-19Us
Levothyroxine SodiumTablet100 ug/1OralPd Rx Pharmaceuticals, Inc.2010-01-18Not applicableUs
Levothyroxine SodiumTablet150 ug/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Levothyroxine SodiumTablet.112 mg/1OralREMEDYREPACK INC.2010-08-042016-10-21Us
Levothyroxine SodiumTablet75 ug/1OralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
Levothyroxine SodiumTablet112 ug/1OralMylan Pharmaceuticals Inc.2002-11-01Not applicableUs
Levothyroxine SodiumTablet25 ug/1OralCardinal Health2010-10-29Not applicableUs
Levothyroxine SodiumTablet25 ug/1OralMylan Institutional Inc.2007-02-26Not applicableUs
Levothyroxine SodiumTablet.137 mg/1OralPhysicians Total Care, Inc.2005-11-21Not applicableUs
Levothyroxine SodiumTablet200 ug/1OralA S Medication Solutions2002-11-01Not applicableUs
Levothyroxine SodiumTablet50 ug/1OralMylan Pharmaceuticals Inc.2002-11-01Not applicableUs
Levothyroxine SodiumTablet100 ug/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
Levothyroxine SodiumTablet50 ug/1OralMylan Institutional Inc.2007-02-05Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
EutiroxMerck
LetroxBerlin-Chemie
LevaxinNycomed
LevothyroxMerck
NovothyroxNot Available
OroxineGlaxoSmithKline
ThyraxMerck
Brand mixtures
NameLabellerIngredients
Np Thyroid 15Acella Pharmaceuticals, LLC
Np Thyroid 30Acella Pharmaceuticals, LLC
Np Thyroid 60Acella Pharmaceuticals, LLC
Np Thyroid 90Acella Pharmaceuticals, LLC
Salts
Name/CASStructureProperties
Levothyroxine sodium
55-03-8
Thumb
  • InChI Key: YDTFRJLNMPSCFM-YDALLXLXSA-M
  • Monoisotopic Mass: 798.668626168
  • Average Mass: 798.8518
DBSALT000244
Categories
UNIIQ51BO43MG4
CAS number51-48-9
WeightAverage: 776.87
Monoisotopic: 776.686681525
Chemical FormulaC15H11I4NO4
InChI KeyXUIIKFGFIJCVMT-LBPRGKRZSA-N
InChI
InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1
IUPAC Name
(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
SMILES
N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C(O)=O
Pharmacology
IndicationFor use alone or in combination with antithyroid agents to treat hypothyroidism, goiter, chronic lymphocytic thyroiditis, myxedema coma, and stupor.
Structured Indications
PharmacodynamicsLevothyroxine (T4) is a synthetically prepared levo isomer of thyroxine, the major hormone secreted from the thyroid gland. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine (T3) which exerts a broad spectrum of stimulatory effects on cell metabolism. Thyroid hormone increases the metabolic rate of cells of all tissues in the body. In the fetus and newborn, thyroid hormone is important for the growth and development of all tissues including bones and the brain. In adults, thyroid hormone helps to maintain brain function, food metabolism, and body temperature, among other effects. The symptoms of thyroid deficiency relieved by levothyroxine include slow speech, lack of energy, weight gain, hair loss, dry thick skin and unusual sensitivity to cold.
Mechanism of actionLevothyroxine acts like the endogenous thyroid hormone thyroxine (T4, a tetra-iodinated tyrosine derivative). In the liver and kidney, T4 is converted to T3, the active metabolite. In order to increase solubility, the thyroid hormones attach to thyroid hormone binding proteins, thyroxin-binding globulin, and thyroxin-binding prealbumin (transthyretin). Transport and binding to thyroid hormone receptors in the cytoplasm and nucleus then takes place. Thus by acting as a replacement for natural thyroxine, symptoms of thyroxine deficiency are relieved.
TargetKindPharmacological actionActionsOrganismUniProt ID
Thyroid hormone receptor alphaProteinyes
agonist
HumanP10827 details
Thyroid hormone receptor betaProteinyes
agonist
HumanP10828 details
Related Articles
AbsorptionBioavailability varies from 48% to 80%. Human studies have confirmed the importance of an intact jejunum and ileum for levothyroxine absorption and have shown some absorption from the duodenum.
Volume of distributionNot Available
Protein binding> 99% to serum proteins, including thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), and albumin (TBA)
Metabolism

Approximately 70% of secreted T4 is deiodinated to equal amounts of T3 and reverse triiodothyronine (rT3), which is calorigenically inactive. Elimination of T4 and T3 involves hepatic conjugation to glucuronic and sulfuric acids. The hormones undergo enterohepatic circulation as conjugates are hydrolyzed in the intestine and reabsorbed. Conjugated compounds that reach the colon are hydrolyzed and eliminated as free compounds in the feces. Other minor T4 metabolites have been identified.

Route of eliminationThyroid hormones are primarily eliminated by the kidneys.
Half lifeT4, 6 to 7 days. T3, 1 to 2 days.
ClearanceNot Available
ToxicityLD50=20 mg/kg (orally in rat). Hypermetabolic state indistinguishable from thyrotoxicosis of endogenous origin. Symptoms of thyrotoxicosis include weight loss, increased appetite, palpitations, nervousness, diarrhea, abdominal cramps, sweating, tachycardia, increased pulse and blood pressure, cardiac arrhythmias, tremors, insomnia, heat intolerance, fever, and menstrual irregularities.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Thyroid hormone synthesisMetabolicSMP00716
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
AcebutololThe serum concentration of Acebutolol can be decreased when it is combined with Levothyroxine.Approved
AcenocoumarolLevothyroxine may increase the anticoagulant activities of Acenocoumarol.Approved
AcetaminophenThe serum concentration of Acetaminophen can be decreased when it is combined with Levothyroxine.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be decreased when it is combined with Levothyroxine.Approved, Vet Approved
AfatinibThe serum concentration of Afatinib can be decreased when it is combined with Levothyroxine.Approved
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Levothyroxine.Experimental
AlitretinoinThe serum concentration of Alitretinoin can be decreased when it is combined with Levothyroxine.Approved, Investigational
Aluminum hydroxideThe serum concentration of Levothyroxine can be decreased when it is combined with Aluminum hydroxide.Approved
AmbrisentanThe serum concentration of Ambrisentan can be decreased when it is combined with Levothyroxine.Approved, Investigational
Ambroxol acefyllinateThe metabolism of Ambroxol acefyllinate can be increased when combined with Levothyroxine.Experimental
AmineptineLevothyroxine may increase the arrhythmogenic activities of Amineptine.Illicit, Withdrawn
AminophyllineThe metabolism of Aminophylline can be increased when combined with Levothyroxine.Approved
AmiodaroneThe metabolism of Levothyroxine can be decreased when combined with Amiodarone.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be decreased when it is combined with Levothyroxine.Approved
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Levothyroxine.Approved
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Levothyroxine.Approved
AprepitantThe serum concentration of Levothyroxine can be increased when it is combined with Aprepitant.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be decreased when it is combined with Levothyroxine.Approved, Investigational
AtazanavirThe metabolism of Levothyroxine can be decreased when combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Atenolol can be decreased when it is combined with Levothyroxine.Approved
AtomoxetineThe metabolism of Levothyroxine can be decreased when combined with Atomoxetine.Approved
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Levothyroxine.Approved, Investigational
BazedoxifeneThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Bazedoxifene.Approved, Investigational
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Levothyroxine.Approved, Vet Approved
BexaroteneThe serum concentration of Levothyroxine can be decreased when it is combined with Bexarotene.Approved, Investigational
BoceprevirThe metabolism of Levothyroxine can be decreased when combined with Boceprevir.Approved
BortezomibThe metabolism of Levothyroxine can be decreased when combined with Bortezomib.Approved, Investigational
BosentanThe serum concentration of Levothyroxine can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Levothyroxine.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Levothyroxine.Approved
BromocriptineThe serum concentration of Bromocriptine can be decreased when it is combined with Levothyroxine.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be decreased when it is combined with Levothyroxine.Approved
CaffeineThe serum concentration of Caffeine can be decreased when it is combined with Levothyroxine.Approved
CalciumThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Calcium.Nutraceutical
Calcium AcetateThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Calcium Acetate.Approved
Calcium carbonateThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Calcium carbonate.Approved
Calcium ChlorideThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Calcium Chloride.Approved
Calcium citrateThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Calcium citrate.Approved
Calcium glubionateThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Calcium glubionate.Approved
Calcium GluceptateThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Calcium Gluceptate.Approved
Calcium gluconateThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Calcium gluconate.Approved, Vet Approved
CamptothecinThe serum concentration of Camptothecin can be decreased when it is combined with Levothyroxine.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be decreased when it is combined with Levothyroxine.Approved
CarbamazepineThe serum concentration of Levothyroxine can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarfilzomibThe serum concentration of Carfilzomib can be decreased when it is combined with Levothyroxine.Approved
CeritinibThe serum concentration of Levothyroxine can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be decreased when it is combined with Levothyroxine.Withdrawn
ChlorotrianiseneThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Chlorotrianisene.Withdrawn
ChlorpromazineThe serum concentration of Chlorpromazine can be decreased when it is combined with Levothyroxine.Approved, Vet Approved
CholestyramineThe serum concentration of Levothyroxine can be decreased when it is combined with Cholestyramine.Approved
CimetidineThe serum concentration of Cimetidine can be decreased when it is combined with Levothyroxine.Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be decreased when it is combined with Levothyroxine.Approved, Investigational
CisplatinThe serum concentration of Cisplatin can be decreased when it is combined with Levothyroxine.Approved
CitalopramThe serum concentration of Citalopram can be decreased when it is combined with Levothyroxine.Approved
ClarithromycinThe metabolism of Levothyroxine can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Levothyroxine can be decreased when combined with Clemastine.Approved
ClobazamThe serum concentration of Clobazam can be decreased when it is combined with Levothyroxine.Approved, Illicit
ClomifeneThe serum concentration of Clomifene can be decreased when it is combined with Levothyroxine.Approved, Investigational
ClomipramineLevothyroxine may increase the arrhythmogenic activities of Clomipramine.Approved, Vet Approved
ClonidineThe serum concentration of Clonidine can be decreased when it is combined with Levothyroxine.Approved
ClopidogrelThe serum concentration of Clopidogrel can be decreased when it is combined with Levothyroxine.Approved, Nutraceutical
ClotrimazoleThe metabolism of Levothyroxine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Levothyroxine.Approved
CobicistatThe metabolism of Levothyroxine can be decreased when combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Levothyroxine.Approved
ColchicineThe serum concentration of Colchicine can be decreased when it is combined with Levothyroxine.Approved
ColesevelamThe serum concentration of Levothyroxine can be decreased when it is combined with Colesevelam.Approved
ColestipolThe serum concentration of Levothyroxine can be decreased when it is combined with Colestipol.Approved
ConivaptanThe serum concentration of Levothyroxine can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Levothyroxine.Approved
CrizotinibThe metabolism of Levothyroxine can be decreased when combined with Crizotinib.Approved
CyclobenzaprineLevothyroxine may increase the arrhythmogenic activities of Cyclobenzaprine.Approved
CyclosporineThe metabolism of Levothyroxine can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be decreased when it is combined with Levothyroxine.Approved
DabrafenibThe serum concentration of Levothyroxine can be decreased when it is combined with Dabrafenib.Approved
DactinomycinThe serum concentration of Dactinomycin can be decreased when it is combined with Levothyroxine.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be decreased when it is combined with Levothyroxine.Approved
DapoxetineThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Dapoxetine.Investigational
DarunavirThe metabolism of Levothyroxine can be decreased when combined with Darunavir.Approved
DasatinibThe serum concentration of Levothyroxine can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be decreased when it is combined with Levothyroxine.Approved
DebrisoquinThe serum concentration of Debrisoquin can be decreased when it is combined with Levothyroxine.Approved
DeferasiroxThe serum concentration of Levothyroxine can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Levothyroxine can be decreased when combined with Delavirdine.Approved
DesipramineLevothyroxine may increase the arrhythmogenic activities of Desipramine.Approved
DesvenlafaxineThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Desvenlafaxine.Approved
DexamethasoneThe serum concentration of Levothyroxine can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DiazepamThe serum concentration of Diazepam can be decreased when it is combined with Levothyroxine.Approved, Illicit, Vet Approved
DicoumarolLevothyroxine may increase the anticoagulant activities of Dicoumarol.Approved
DienestrolThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Dienestrol.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be decreased when it is combined with Levothyroxine.Approved
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Levothyroxine.Approved
DigoxinThe serum concentration of Digoxin can be decreased when it is combined with Levothyroxine.Approved
DihydroergotamineThe metabolism of Levothyroxine can be decreased when combined with Dihydroergotamine.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Levothyroxine.Illicit
DiltiazemThe metabolism of Levothyroxine can be decreased when combined with Diltiazem.Approved
DipyridamoleThe serum concentration of Dipyridamole can be decreased when it is combined with Levothyroxine.Approved
DocetaxelThe serum concentration of Docetaxel can be decreased when it is combined with Levothyroxine.Approved, Investigational
DomperidoneThe serum concentration of Domperidone can be decreased when it is combined with Levothyroxine.Approved, Investigational, Vet Approved
DosulepinLevothyroxine may increase the arrhythmogenic activities of Dosulepin.Approved
DoxepinLevothyroxine may increase the arrhythmogenic activities of Doxepin.Approved
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Levothyroxine.Approved, Investigational
DoxycyclineThe metabolism of Levothyroxine can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronedaroneThe metabolism of Levothyroxine can be decreased when combined with Dronedarone.Approved
DuloxetineThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Duloxetine.Approved
DyphyllineThe metabolism of Dyphylline can be increased when combined with Levothyroxine.Approved
EdoxabanThe serum concentration of Edoxaban can be decreased when it is combined with Levothyroxine.Approved
EfavirenzThe serum concentration of Levothyroxine can be decreased when it is combined with Efavirenz.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be decreased when it is combined with Levothyroxine.Approved, Investigational
EnzalutamideThe serum concentration of Levothyroxine can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe serum concentration of Epinastine can be decreased when it is combined with Levothyroxine.Approved, Investigational
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Levothyroxine.Approved, Investigational
ErythromycinThe metabolism of Levothyroxine can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Escitalopram.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Levothyroxine can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmirtazapineLevothyroxine may increase the arrhythmogenic activities of Esmirtazapine.Investigational
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Levothyroxine.Approved, Investigational, Vet Approved
EstriolThe serum concentration of Estriol can be decreased when it is combined with Levothyroxine.Approved, Vet Approved
EstroneThe serum concentration of Estrone can be decreased when it is combined with Levothyroxine.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Levothyroxine.Approved
Ethyl biscoumacetateLevothyroxine may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
EtoperidoneThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Etoperidone.Approved
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Levothyroxine.Approved
EtravirineThe serum concentration of Levothyroxine can be decreased when it is combined with Etravirine.Approved
EzetimibeThe serum concentration of Ezetimibe can be decreased when it is combined with Levothyroxine.Approved
Ferric CarboxymaltoseThe serum concentration of Levothyroxine can be decreased when it is combined with Ferric Carboxymaltose.Approved
Ferric CitrateThe serum concentration of Levothyroxine can be decreased when it is combined with Ferric Citrate.Approved
Ferric pyrophosphateThe serum concentration of Levothyroxine can be decreased when it is combined with Ferric pyrophosphate.Approved
FesoterodineThe serum concentration of Fesoterodine can be decreased when it is combined with Levothyroxine.Approved
FexofenadineThe serum concentration of Fexofenadine can be decreased when it is combined with Levothyroxine.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be decreased when it is combined with Levothyroxine.Approved
FluconazoleThe metabolism of Levothyroxine can be decreased when combined with Fluconazole.Approved
FluindioneLevothyroxine may increase the anticoagulant activities of Fluindione.Investigational
FluoxetineThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Fluoxetine.Approved, Vet Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with Levothyroxine.Approved
FluvoxamineThe metabolism of Levothyroxine can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe metabolism of Levothyroxine can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Levothyroxine can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Levothyroxine can be decreased when it is combined with Fosphenytoin.Approved
Fusidic AcidThe serum concentration of Levothyroxine can be increased when it is combined with Fusidic Acid.Approved
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Levothyroxine.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be decreased when it is combined with Levothyroxine.Approved
GenisteinThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Genistein.Investigational
GrazoprevirThe serum concentration of Grazoprevir can be decreased when it is combined with Levothyroxine.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with Levothyroxine.Withdrawn
HaloperidolThe serum concentration of Haloperidol can be decreased when it is combined with Levothyroxine.Approved
HexestrolThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Hexestrol.Withdrawn
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Levothyroxine.Approved, Vet Approved
IbuprofenThe serum concentration of Ibuprofen can be decreased when it is combined with Levothyroxine.Approved
IdelalisibThe serum concentration of Levothyroxine can be increased when it is combined with Idelalisib.Approved
ImatinibThe metabolism of Levothyroxine can be decreased when combined with Imatinib.Approved
ImipramineThe serum concentration of Imipramine can be decreased when it is combined with Levothyroxine.Approved
IndacaterolThe serum concentration of Indacaterol can be decreased when it is combined with Levothyroxine.Approved
IndalpineThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Indalpine.Investigational, Withdrawn
IndinavirThe metabolism of Levothyroxine can be decreased when combined with Indinavir.Approved
IndomethacinThe serum concentration of Indomethacin can be decreased when it is combined with Levothyroxine.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be decreased when it is combined with Levothyroxine.Approved, Investigational
IronThe serum concentration of Levothyroxine can be decreased when it is combined with Iron.Approved
Iron DextranThe serum concentration of Levothyroxine can be decreased when it is combined with Iron Dextran.Approved, Vet Approved
Iron saccharateThe serum concentration of Levothyroxine can be decreased when it is combined with Iron saccharate.Approved
IsavuconazoniumThe metabolism of Levothyroxine can be decreased when combined with Isavuconazonium.Approved, Investigational
IsradipineThe metabolism of Levothyroxine can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Levothyroxine can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Levothyroxine can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Ivermectin can be decreased when it is combined with Levothyroxine.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be decreased when it is combined with Levothyroxine.Approved
KetoconazoleThe metabolism of Levothyroxine can be decreased when combined with Ketoconazole.Approved, Investigational
LamivudineThe serum concentration of Lamivudine can be decreased when it is combined with Levothyroxine.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be decreased when it is combined with Levothyroxine.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be decreased when it is combined with Levothyroxine.Approved, Investigational
Lanthanum carbonateThe serum concentration of Levothyroxine can be decreased when it is combined with Lanthanum carbonate.Approved
LedipasvirThe serum concentration of Ledipasvir can be decreased when it is combined with Levothyroxine.Approved
LenalidomideThe serum concentration of Lenalidomide can be decreased when it is combined with Levothyroxine.Approved
LenvatinibThe serum concentration of Lenvatinib can be decreased when it is combined with Levothyroxine.Approved
LevetiracetamThe serum concentration of Levetiracetam can be decreased when it is combined with Levothyroxine.Approved, Investigational
LevofloxacinThe serum concentration of Levofloxacin can be decreased when it is combined with Levothyroxine.Approved, Investigational
LevomilnacipranThe serum concentration of Levomilnacipran can be decreased when it is combined with Levothyroxine.Approved
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Levothyroxine.Approved
LoperamideThe serum concentration of Loperamide can be decreased when it is combined with Levothyroxine.Approved
LopinavirThe metabolism of Levothyroxine can be decreased when combined with Lopinavir.Approved
LosartanThe serum concentration of Losartan can be decreased when it is combined with Levothyroxine.Approved
LovastatinThe metabolism of Levothyroxine can be decreased when combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Levothyroxine can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Levothyroxine can be increased when combined with Lumacaftor.Approved
Magnesium hydroxideThe serum concentration of Levothyroxine can be decreased when it is combined with Magnesium hydroxide.Approved
Magnesium oxideThe serum concentration of Levothyroxine can be decreased when it is combined with Magnesium oxide.Approved
Magnesium salicylateThe serum concentration of Levothyroxine can be decreased when it is combined with Magnesium salicylate.Approved
Magnesium SulfateThe serum concentration of Levothyroxine can be decreased when it is combined with Magnesium Sulfate.Approved, Vet Approved
MannitolThe serum concentration of Mannitol can be decreased when it is combined with Levothyroxine.Approved, Investigational
MestranolThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Mestranol.Approved
MethallenestrilThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Methallenestril.Experimental
MethotrexateThe serum concentration of Methotrexate can be decreased when it is combined with Levothyroxine.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Levothyroxine.Approved, Vet Approved
MetoprololThe serum concentration of Metoprolol can be decreased when it is combined with Levothyroxine.Approved, Investigational
MidazolamThe serum concentration of Midazolam can be decreased when it is combined with Levothyroxine.Approved, Illicit
MifepristoneThe serum concentration of Levothyroxine can be increased when it is combined with Mifepristone.Approved, Investigational
MilnacipranThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Milnacipran.Approved
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with Levothyroxine.Approved
MirtazapineLevothyroxine may increase the arrhythmogenic activities of Mirtazapine.Approved
MitotaneThe serum concentration of Levothyroxine can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be decreased when it is combined with Levothyroxine.Approved, Investigational
ModafinilThe serum concentration of Levothyroxine can be decreased when it is combined with Modafinil.Approved, Investigational
MorphineThe serum concentration of Morphine can be decreased when it is combined with Levothyroxine.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be decreased when it is combined with Levothyroxine.Approved, Investigational
NadololThe serum concentration of Nadolol can be decreased when it is combined with Levothyroxine.Approved
NafcillinThe serum concentration of Levothyroxine can be decreased when it is combined with Nafcillin.Approved
NaloxoneThe serum concentration of Naloxone can be decreased when it is combined with Levothyroxine.Approved, Vet Approved
NefazodoneThe metabolism of Levothyroxine can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Levothyroxine can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Levothyroxine can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Levothyroxine can be increased when combined with Nevirapine.Approved
NicardipineThe serum concentration of Nicardipine can be decreased when it is combined with Levothyroxine.Approved
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Levothyroxine.Approved
NilotinibThe metabolism of Levothyroxine can be decreased when combined with Nilotinib.Approved, Investigational
NintedanibThe serum concentration of Nintedanib can be decreased when it is combined with Levothyroxine.Approved
NizatidineThe serum concentration of Nizatidine can be decreased when it is combined with Levothyroxine.Approved
NortriptylineLevothyroxine may increase the arrhythmogenic activities of Nortriptyline.Approved
OlanzapineThe serum concentration of Olanzapine can be decreased when it is combined with Levothyroxine.Approved, Investigational
OlaparibThe metabolism of Levothyroxine can be decreased when combined with Olaparib.Approved
OmbitasvirThe serum concentration of Ombitasvir can be decreased when it is combined with Levothyroxine.Approved
OpipramolLevothyroxine may increase the arrhythmogenic activities of Opipramol.Investigational
OrlistatThe serum concentration of Levothyroxine can be decreased when it is combined with Orlistat.Approved, Investigational
OsimertinibThe serum concentration of Levothyroxine can be increased when it is combined with Osimertinib.Approved
PaclitaxelThe serum concentration of Paclitaxel can be decreased when it is combined with Levothyroxine.Approved, Vet Approved
PalbociclibThe serum concentration of Levothyroxine can be increased when it is combined with Palbociclib.Approved
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Levothyroxine.Approved, Investigational
ParoxetineThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Levothyroxine.Approved
PentobarbitalThe metabolism of Levothyroxine can be increased when combined with Pentobarbital.Approved, Vet Approved
PhenindioneLevothyroxine may increase the anticoagulant activities of Phenindione.Approved
PhenobarbitalThe metabolism of Levothyroxine can be increased when combined with Phenobarbital.Approved
PhenprocoumonLevothyroxine may increase the anticoagulant activities of Phenprocoumon.Approved
PhenytoinThe serum concentration of Levothyroxine can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PiracetamThe risk or severity of adverse effects can be increased when Piracetam is combined with Levothyroxine.Approved
PitavastatinThe serum concentration of Pitavastatin can be decreased when it is combined with Levothyroxine.Approved
PolaprezincThe serum concentration of Levothyroxine can be decreased when it is combined with Polaprezinc.Approved
Polyestradiol phosphateThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Polyestradiol phosphate.Approved
Polystyrene sulfonateThe serum concentration of Levothyroxine can be decreased when it is combined with Polystyrene sulfonate.Approved
PomalidomideThe serum concentration of Pomalidomide can be decreased when it is combined with Levothyroxine.Approved
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Levothyroxine.Approved
PosaconazoleThe metabolism of Levothyroxine can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Levothyroxine.Approved
PrazosinThe serum concentration of Prazosin can be decreased when it is combined with Levothyroxine.Approved
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Levothyroxine.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Levothyroxine.Approved, Vet Approved
PrimidoneThe metabolism of Levothyroxine can be increased when combined with Primidone.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be decreased when it is combined with Levothyroxine.Approved, Vet Approved
PromestrieneThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Promestriene.Investigational
PropranololThe serum concentration of Propranolol can be decreased when it is combined with Levothyroxine.Approved, Investigational
ProtriptylineLevothyroxine may increase the arrhythmogenic activities of Protriptyline.Approved
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Levothyroxine.Approved
QuinestrolThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Quinestrol.Approved
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Levothyroxine.Approved
QuinineThe serum concentration of Quinine can be decreased when it is combined with Levothyroxine.Approved
RaloxifeneRaloxifene can cause a decrease in the absorption of Levothyroxine resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
RanitidineThe serum concentration of Ranitidine can be decreased when it is combined with Levothyroxine.Approved
RanolazineThe metabolism of Levothyroxine can be decreased when combined with Ranolazine.Approved, Investigational
ReserpineThe serum concentration of Reserpine can be decreased when it is combined with Levothyroxine.Approved
RifabutinThe metabolism of Levothyroxine can be increased when combined with Rifabutin.Approved
RifampicinThe serum concentration of Levothyroxine can be decreased when it is combined with Rifampicin.Approved
RifapentineThe metabolism of Levothyroxine can be increased when combined with Rifapentine.Approved
RisperidoneThe serum concentration of Risperidone can be decreased when it is combined with Levothyroxine.Approved, Investigational
RitonavirThe metabolism of Levothyroxine can be decreased when combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Levothyroxine.Approved
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Levothyroxine.Approved, Investigational
S EquolThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with S Equol.Investigational
Salicylic acidThe serum concentration of Salicylic acid can be decreased when it is combined with Levothyroxine.Approved, Vet Approved
SaquinavirThe metabolism of Levothyroxine can be decreased when combined with Saquinavir.Approved, Investigational
SecoisolariciresinolThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Secoisolariciresinol.Investigational
SelexipagThe serum concentration of Selexipag can be decreased when it is combined with Levothyroxine.Approved
SertralineThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Sertraline.Approved
SevelamerThe serum concentration of Levothyroxine can be decreased when it is combined with Sevelamer.Approved
SildenafilThe metabolism of Levothyroxine can be decreased when combined with Sildenafil.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be decreased when it is combined with Levothyroxine.Approved
SiltuximabThe serum concentration of Levothyroxine can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Levothyroxine can be increased when it is combined with Simeprevir.Approved
SitagliptinThe serum concentration of Sitagliptin can be decreased when it is combined with Levothyroxine.Approved, Investigational
Sodium Iodide I-131The therapeutic efficacy of Sodium Iodide I-131 can be decreased when used in combination with Levothyroxine.Approved
SofosbuvirThe serum concentration of Sofosbuvir can be decreased when it is combined with Levothyroxine.Approved
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Levothyroxine.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be decreased when it is combined with Levothyroxine.Approved
SphingosineThe serum concentration of Sphingosine can be decreased when it is combined with Levothyroxine.Experimental
St. John's WortThe serum concentration of Levothyroxine can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Levothyroxine can be increased when it is combined with Stiripentol.Approved
SucralfateThe serum concentration of Levothyroxine can be decreased when it is combined with Sucralfate.Approved
SulfisoxazoleThe metabolism of Levothyroxine can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
Synthetic Conjugated Estrogens, AThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Synthetic Conjugated Estrogens, A.Approved
Synthetic Conjugated Estrogens, BThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Synthetic Conjugated Estrogens, B.Approved
TacrolimusThe serum concentration of Tacrolimus can be decreased when it is combined with Levothyroxine.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be decreased when it is combined with Levothyroxine.Approved
Taurocholic AcidThe serum concentration of Taurocholic Acid can be decreased when it is combined with Levothyroxine.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be decreased when it is combined with Levothyroxine.Approved
TelaprevirThe metabolism of Levothyroxine can be decreased when combined with Telaprevir.Approved
TelithromycinThe metabolism of Levothyroxine can be decreased when combined with Telithromycin.Approved
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Levothyroxine.Approved
TheophyllineThe metabolism of Theophylline can be increased when combined with Levothyroxine.Approved
TianeptineLevothyroxine may increase the arrhythmogenic activities of Tianeptine.Approved
TiboloneThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Tibolone.Approved
TicagrelorThe serum concentration of Ticagrelor can be decreased when it is combined with Levothyroxine.Approved
TiclopidineThe metabolism of Levothyroxine can be decreased when combined with Ticlopidine.Approved
TimololThe serum concentration of Timolol can be decreased when it is combined with Levothyroxine.Approved
TocilizumabThe serum concentration of Levothyroxine can be decreased when it is combined with Tocilizumab.Approved
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Levothyroxine.Approved
TopotecanThe serum concentration of Topotecan can be decreased when it is combined with Levothyroxine.Approved, Investigational
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Levothyroxine.Approved, Investigational
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be decreased when it is combined with Levothyroxine.Approved
TrimipramineLevothyroxine may increase the arrhythmogenic activities of Trimipramine.Approved
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Levothyroxine.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be decreased when it is combined with Levothyroxine.Approved
VecuroniumThe serum concentration of Vecuronium can be decreased when it is combined with Levothyroxine.Approved
VenetoclaxThe serum concentration of Venetoclax can be decreased when it is combined with Levothyroxine.Approved
VenlafaxineThe metabolism of Levothyroxine can be decreased when combined with Venlafaxine.Approved
VerapamilThe metabolism of Levothyroxine can be decreased when combined with Verapamil.Approved
VinblastineThe serum concentration of Vinblastine can be decreased when it is combined with Levothyroxine.Approved
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Levothyroxine.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be decreased when it is combined with Levothyroxine.Approved
VoriconazoleThe metabolism of Levothyroxine can be decreased when combined with Voriconazole.Approved, Investigational
WarfarinLevothyroxine may increase the anticoagulant activities of Warfarin.Approved
ZeranolThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Zeranol.Vet Approved
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Levothyroxine.Approved
ZimelidineThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Levothyroxine can be decreased when combined with Ziprasidone.Approved
Food Interactions
  • Absorption increased in fasting state and decreased in malabsorption states.
  • Consistent administration in relation to meals is recommended.
  • No iron or calium carbonate within 4 hours of taking this medication.
  • Oral administration with infant soybean formula, soybean flour, cotton seed meal, walnuts, foods containing large amounts of fiber, ferrous sulfate, and antacids may decrease drug absorption.
  • Take 30-60 minutes before breakfast.
References
Synthesis Reference

Jivn-Ren Chen, Dimitri C. Papadimitriou, “Stable dosage of levothyroxine sodium and process of production.” U.S. Patent US5225204, issued November, 1991.

US5225204
General References
  1. Uchino H, Kanai Y, Kim DK, Wempe MF, Chairoungdua A, Morimoto E, Anders MW, Endou H: Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition. Mol Pharmacol. 2002 Apr;61(4):729-37. [PubMed:11901210 ]
External Links
ATC CodesH03AA01
AHFS Codes
  • 68:36.04
PDB EntriesNot Available
FDA labelDownload (54.3 KB)
MSDSDownload (51.7 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.7212
Blood Brain Barrier-0.6886
Caco-2 permeable-0.653
P-glycoprotein substrateNon-substrate0.5321
P-glycoprotein inhibitor INon-inhibitor0.9175
P-glycoprotein inhibitor IINon-inhibitor0.9709
Renal organic cation transporterNon-inhibitor0.8891
CYP450 2C9 substrateNon-substrate0.8309
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.6847
CYP450 1A2 substrateNon-inhibitor0.5924
CYP450 2C9 inhibitorNon-inhibitor0.7037
CYP450 2D6 inhibitorNon-inhibitor0.923
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.831
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8459
Ames testNon AMES toxic0.7591
CarcinogenicityNon-carcinogens0.9148
BiodegradationNot ready biodegradable0.9693
Rat acute toxicity2.7082 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9697
hERG inhibition (predictor II)Non-inhibitor0.8508
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Institute biochimique sa (ibsa)
  • Institut biochimique sa ibsa
  • Vintage pharmaceuticals llc
  • Alara pharmaceutical corporation
  • Lloyd inc
  • Merck kgaa
  • Mylan pharmaceuticals inc
  • King pharmaceuticals inc
  • Abbott laboratories
  • Jerome stevens pharmaceuticals inc
Packagers
Dosage forms
FormRouteStrength
TabletOral100 mcg
TabletOral150 mcg
TabletOral200 mcg
TabletOral50 mcg
TabletOral.1 mg
TabletOral.2 mg
TabletOral.3 mg
TabletOral.05 mg
TabletOral112 mcg
TabletOral125 mcg
TabletOral137 mcg
TabletOral175 mcg
TabletOral25 mcg
TabletOral300 mcg
TabletOral75 mcg
TabletOral88 mcg
Injection, powder, lyophilized, for solutionIntravenous100 ug/5mL
Injection, powder, lyophilized, for solutionIntravenous200 ug/5mL
Injection, powder, lyophilized, for solutionIntravenous500 ug/5mL
TabletOral.025 mg/1
TabletOral.05 mg/1
TabletOral.075 mg/1
TabletOral.088 mg/1
TabletOral.1 mg/1
TabletOral.112 mg/1
TabletOral.125 mg/1
TabletOral.137 mg/1
TabletOral.15 mg/1
TabletOral.175 mg/1
TabletOral.2 mg/1
TabletOral.3 mg/1
TabletOral100 ug/1
TabletOral112 ug/1
TabletOral125 ug/1
TabletOral137 ug/1
TabletOral150 ug/1
TabletOral175 ug/1
TabletOral200 ug/1
TabletOral25 ug/1
TabletOral300 ug/1
TabletOral50 ug/1
TabletOral75 ug/1
TabletOral88 ug/1
Powder, for solutionIntramuscular; Intravenous200 mcg
Powder, for solutionIntramuscular; Intravenous500 mcg
TabletTopical
TabletOral
LiquidIntravenous500 mcg
CapsuleOral100 ug/1
CapsuleOral112 ug/1
CapsuleOral125 ug/1
CapsuleOral13 ug/1
CapsuleOral137 ug/1
CapsuleOral150 ug/1
CapsuleOral25 ug/1
CapsuleOral50 ug/1
CapsuleOral75 ug/1
CapsuleOral88 ug/1
Prices
Unit descriptionCostUnit
Levothyroxine sodium powder159.12USD g
Levothyroxine 200 mcg vial24.0USD vial
Levothyroxine 500 mcg vial24.0USD vial
Levoxyl 300 mcg tablet2.34USD tablet
Synthroid 300 mcg tablet1.29USD tablet
Synthroid 175 mcg tablet1.07USD tablet
Synthroid 200 mcg tablet0.99USD tablet
Synthroid 137 mcg tablet0.87USD tablet
Synthroid 112 mcg tablet0.84USD tablet
Synthroid 125 mcg tablet0.84USD tablet
Synthroid 150 mcg tablet0.83USD tablet
Levothyroxine Sodium 300 mcg tablet0.77USD tablet
Synthroid 100 mcg tablet0.73USD tablet
Synthroid 75 mcg tablet0.72USD tablet
Synthroid 88 mcg tablet0.71USD tablet
Levoxyl 200 mcg tablet0.7USD tablet
Levoxyl 175 mcg tablet0.69USD tablet
Unithroid 300 mcg tablet0.69USD tablet
Synthroid 50 mcg tablet0.65USD tablet
Levoxyl 137 mcg tablet0.62USD tablet
Unithroid 200 mcg tablet0.62USD tablet
Levoxyl 112 mcg tablet0.61USD tablet
Synthroid 25 mcg tablet0.61USD tablet
Unithroid 175 mcg tablet0.61USD tablet
Levoxyl 150 mcg tablet0.59USD tablet
Levoxyl 125 mcg tablet0.58USD tablet
Levothyroxine Sodium 175 mcg tablet0.57USD tablet
Levothyroxine Sodium 200 mcg tablet0.57USD tablet
Levothyroxine 175 mcg tablet0.55USD tablet
Unithroid 150 mcg tablet0.55USD tablet
Levoxyl 88 mcg tablet0.54USD tablet
Unithroid 112 mcg tablet0.53USD tablet
Unithroid 125 mcg tablet0.53USD tablet
Levoxyl 75 mcg tablet0.52USD tablet
Levothroid 300 mcg tablet0.51USD tablet
Levoxyl 100 mcg tablet0.51USD tablet
Levothyroxine Sodium 100 mcg tablet0.5USD tablet
Levothyroxine Sodium 150 mcg tablet0.5USD tablet
Levothyroxine Sodium 88 mcg tablet0.5USD tablet
Levoxyl 50 mcg tablet0.49USD tablet
Unithroid 88 mcg tablet0.49USD tablet
Unithroid 100 mcg tablet0.47USD tablet
Unithroid 75 mcg tablet0.47USD tablet
Levothyroxine Sodium 125 mcg tablet0.47USD tablet
Levothyroxine Sodium 137 mcg tablet0.47USD tablet
Levothyroxine Sodium 50 mcg tablet0.47USD tablet
Levothyroxine Sodium 75 mcg tablet0.47USD tablet
Levothyroxine Sodium 112 mcg tablet0.46USD tablet
Levothyroxine 137 mcg tablet0.45USD tablet
Levoxyl 25 mcg tablet0.45USD tablet
Levothyroxine 112 mcg tablet0.44USD tablet
Levothyroxine Sodium 25 mcg tablet0.43USD tablet
Unithroid 50 mcg tablet0.43USD tablet
Unithroid 25 mcg tablet0.42USD tablet
Unithroid direct 100 mcg tablet0.42USD tablet
Unithroid direct 112 mcg tablet0.42USD tablet
Unithroid direct 125 mcg tablet0.42USD tablet
Unithroid direct 150 mcg tablet0.42USD tablet
Unithroid direct 175 mcg tablet0.42USD tablet
Unithroid direct 200 mcg tablet0.42USD tablet
Unithroid direct 25 mcg tablet0.42USD tablet
Unithroid direct 300 mcg tablet0.42USD tablet
Unithroid direct 50 mcg tablet0.42USD tablet
Unithroid direct 75 mcg tablet0.42USD tablet
Unithroid direct 88 mcg tablet0.42USD tablet
Levothroid 200 mcg tablet0.4USD tablet
Levothroid 175 mcg tablet0.38USD tablet
Levothyroxine 88 mcg tablet0.38USD tablet
Levothroid 125 mcg tablet0.36USD tablet
Levothroid 150 mcg tablet0.36USD tablet
Levothroid 100 mcg tablet0.35USD tablet
Levothroid 137 mcg tablet0.35USD tablet
Levothroid 112 mcg tablet0.34USD tablet
Levothroid 75 mcg tablet0.33USD tablet
Levothroid 88 mcg tablet0.33USD tablet
Levothyroxine 300 mcg tablet0.32USD tablet
Levothroid 25 mcg tablet0.31USD tablet
Unithroid 137 mcg tablet0.31USD tablet
Levothroid 50 mcg tablet0.3USD tablet
Levothyroxine 200 mcg tablet0.29USD tablet
Levothyroxine 150 mcg tablet0.24USD tablet
Levothyroxine 125 mcg tablet0.22USD tablet
Levothyroxine 100 mcg tablet0.2USD tablet
Levothyroxine 75 mcg tablet0.2USD tablet
Levothyroxine 50 mcg tablet0.18USD tablet
Synthroid 0.137 mg Tablet0.18USD tablet
Levothyroxine 25 mcg tablet0.17USD tablet
Synthroid 0.3 mg Tablet0.12USD tablet
Synthroid 0.175 mg Tablet0.11USD tablet
Synthroid 0.075 mg Tablet0.1USD tablet
Synthroid 0.088 mg Tablet0.1USD tablet
Synthroid 0.112 mg Tablet0.1USD tablet
Synthroid 0.125 mg Tablet0.1USD tablet
Synthroid 0.025 mg Tablet0.09USD tablet
Synthroid 0.2 mg Tablet0.09USD tablet
Synthroid 0.1 mg Tablet0.08USD tablet
Synthroid 0.15 mg Tablet0.08USD tablet
Eltroxin 0.3 mg Tablet0.07USD tablet
Synthroid 0.05 mg Tablet0.06USD tablet
Eltroxin 0.2 mg Tablet0.05USD tablet
Eltroxin 0.1 mg Tablet0.04USD tablet
Eltroxin 0.15 mg Tablet0.04USD tablet
Eltroxin 0.05 mg Tablet0.03USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6399101 No2000-03-302020-03-30Us
US6555581 No2002-02-152022-02-15Us
US7067148 No2002-02-152022-02-15Us
US7101569 No2003-10-022023-10-02Us
US7723390 No2004-03-142024-03-14Us
US9006289 No2012-10-032032-10-03Us
US9168238 No2012-08-292032-08-29Us
US9168239 No2012-08-292032-08-29Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point235.5 °CPhysProp
water solubility0.105 mg/mLNot Available
logP4Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00898 mg/mLALOGPS
logP1.15ALOGPS
logP3.73ChemAxon
logS-4.9ALOGPS
pKa (Strongest Acidic)0.27ChemAxon
pKa (Strongest Basic)9.43ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area92.78 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity126.79 m3·mol-1ChemAxon
Polarizability49.4 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-0ac9-0591664310-c9b7aec3184ebb20a2daView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-014i-2566449540-35bb942c7bcbcfe41af7View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-00xr-3375497520-9dee3cb0c153e6c6df9eView in MoNA
1D NMR1H NMR SpectrumNot Available
2D NMR[1H,13C] 2D NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as diphenylethers. These are aromatic compounds containing two benzene rings linked to each other through an ether group.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassDiphenylethers
Direct ParentDiphenylethers
Alternative Parents
Substituents
  • Diphenylether
  • 3-phenylpropanoic-acid
  • Diaryl ether
  • L-alpha-amino acid
  • Amphetamine or derivatives
  • Alpha-amino acid or derivatives
  • Alpha-amino acid
  • 2-iodophenol
  • 2-halophenol
  • Aralkylamine
  • Phenol
  • Iodobenzene
  • Halobenzene
  • Amino fatty acid
  • Fatty acyl
  • Aryl iodide
  • Aryl halide
  • Monocarboxylic acid or derivatives
  • Ether
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Organoiodide
  • Organohalogen compound
  • Primary aliphatic amine
  • Carbonyl group
  • Amine
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Zinc ion binding
Specific Function:
Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.Isoform Alpha-2: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.
Gene Name:
THRA
Uniprot ID:
P10827
Molecular Weight:
54815.055 Da
References
  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  2. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  3. Bernal J: Thyroid hormone receptors in brain development and function. Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):249-59. [PubMed:17315033 ]
  4. Nakajima Y, Yamada M, Horiguchi K, Satoh T, Hashimoto K, Tokuhiro E, Onigata K, Mori M: Resistance to thyroid hormone due to a novel thyroid hormone receptor mutant in a patient with hypothyroidism secondary to lingual thyroid and functional characterization of the mutant receptor. Thyroid. 2010 Aug;20(8):917-26. doi: 10.1089/thy.2009.0389. [PubMed:20615127 ]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Zinc ion binding
Specific Function:
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Gene Name:
THRB
Uniprot ID:
P10828
Molecular Weight:
52787.16 Da
References
  1. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  2. Marazuela M, Nattero L, Moure D, Garcia-Polo I, Figueroa-Vega N, Guijarro C: Thyroid hormone resistance and pituitary enlargement after thyroid ablation in a woman on levothyroxine treatment. Thyroid. 2008 Oct;18(10):1119-23. doi: 10.1089/thy.2007.0375. [PubMed:18816177 ]
  3. Sivakumar T, Chaidarun S: Resistance to thyroid hormone in a patient with coexisting Graves' disease. Thyroid. 2010 Feb;20(2):213-6. doi: 10.1089/thy.2009.0175. [PubMed:20151830 ]
  4. Grasberger H, Ringkananont U, Croxson M, Refetoff S: Resistance to thyroid hormone in a patient with thyroid dysgenesis. Thyroid. 2005 Jul;15(7):730-3. [PubMed:16053391 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. [PubMed:15601807 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
no
General Function:
Identical protein binding
Specific Function:
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
Gene Name:
TTR
Uniprot ID:
P02766
Molecular Weight:
15886.88 Da
References
  1. Eneqvist T, Lundberg E, Karlsson A, Huang S, Santos CR, Power DM, Sauer-Eriksson AE: High resolution crystal structures of piscine transthyretin reveal different binding modes for triiodothyronine and thyroxine. J Biol Chem. 2004 Jun 18;279(25):26411-6. Epub 2004 Apr 13. [PubMed:15082720 ]
  2. Palha JA: Transthyretin as a thyroid hormone carrier: function revisited. Clin Chem Lab Med. 2002 Dec;40(12):1292-300. [PubMed:12553433 ]
Kind
Protein
Organism
Human
Pharmacological action
no
General Function:
Serine-type endopeptidase inhibitor activity
Specific Function:
Major thyroid hormone transport protein in serum.
Gene Name:
SERPINA7
Uniprot ID:
P05543
Molecular Weight:
46324.12 Da
References
  1. Palha JA: Transthyretin as a thyroid hormone carrier: function revisited. Clin Chem Lab Med. 2002 Dec;40(12):1292-300. [PubMed:12553433 ]
Kind
Protein
Organism
Human
Pharmacological action
no
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da
References
  1. Palha JA: Transthyretin as a thyroid hormone carrier: function revisited. Clin Chem Lab Med. 2002 Dec;40(12):1292-300. [PubMed:12553433 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Thyroid hormone transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity).
Gene Name:
SLCO1C1
Uniprot ID:
Q9NYB5
Molecular Weight:
78695.625 Da
References
  1. Westholm DE, Stenehjem DD, Rumbley JN, Drewes LR, Anderson GW: Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs. Endocrinology. 2009 Feb;150(2):1025-32. doi: 10.1210/en.2008-0188. Epub 2008 Oct 9. [PubMed:18845642 ]
  2. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
  3. Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ: Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002 Oct;16(10):2283-96. [PubMed:12351693 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr.
Gene Name:
SLC16A2
Uniprot ID:
P36021
Molecular Weight:
59510.86 Da
References
  1. Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, Visser TJ: Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem. 2003 Oct 10;278(41):40128-35. Epub 2003 Jul 18. [PubMed:12871948 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Siegmund W, Altmannsberger S, Paneitz A, Hecker U, Zschiesche M, Franke G, Meng W, Warzok R, Schroeder E, Sperker B, Terhaag B, Cascorbi I, Kroemer HK: Effect of levothyroxine administration on intestinal P-glycoprotein expression: consequences for drug disposition. Clin Pharmacol Ther. 2002 Sep;72(3):256-64. [PubMed:12235446 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. [PubMed:11159893 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
References
  1. Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. [PubMed:11159893 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B3
Uniprot ID:
Q9NPD5
Molecular Weight:
77402.175 Da
References
  1. Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. [PubMed:11159893 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Thyroid hormone transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate.
Gene Name:
SLCO4A1
Uniprot ID:
Q96BD0
Molecular Weight:
77192.505 Da
References
  1. Fujiwara K, Adachi H, Nishio T, Unno M, Tokui T, Okabe M, Onogawa T, Suzuki T, Asano N, Tanemoto M, Seki M, Shiiba K, Suzuki M, Kondo Y, Nunoki K, Shimosegawa T, Iinuma K, Ito S, Matsuno S, Abe T: Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology. 2001 May;142(5):2005-12. [PubMed:11316767 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first...
Gene Name:
SLCO4C1
Uniprot ID:
Q6ZQN7
Molecular Weight:
78947.525 Da
References
  1. Mikkaichi T, Suzuki T, Onogawa T, Tanemoto M, Mizutamari H, Okada M, Chaki T, Masuda S, Tokui T, Eto N, Abe M, Satoh F, Unno M, Hishinuma T, Inui K, Ito S, Goto J, Abe T: Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. Epub 2004 Mar 1. [PubMed:14993604 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Peptide antigen binding
Specific Function:
Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the ...
Gene Name:
SLC7A5
Uniprot ID:
Q01650
Molecular Weight:
55009.62 Da
References
  1. Uchino H, Kanai Y, Kim DK, Wempe MF, Chairoungdua A, Morimoto E, Anders MW, Endou H: Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition. Mol Pharmacol. 2002 Apr;61(4):729-37. [PubMed:11901210 ]
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Drug created on June 13, 2005 07:24 / Updated on December 03, 2016 02:46