OAT1/SLC22A6 Substrates

DrugDrug NameDrug Indication
DB00345Aminohippuric acidUsed to measure effective renal plasma flow (ERPF) and to determine the functional capacity of the tubular excretory mechanism.
DB03553Glutaric AcidNot Available
DB00369CidofovirFor the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS)
DB00718Adefovir dipivoxilIndicated for the treatment of chronic hepatitis B in adult patients with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease; this is based on histological, virological, biochemical, and serological responses in adult patients with HBeAg+ and HBeAg- chronic hepatitis B with compensated liver function, and in adult patients with clinical evidence of lamivudine-resistant hepatitis B virus with either compensated or decompensated liver function.
DB00501CimetidineFor the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion.
DB00787AcyclovirAn acyclovir topical cream is indicated to treat recurrent herpes labialis in immunocompetent patients 12 years and older.[L7303] Acyclovir oral tablets, capsules, and suspensions are indicated to treat herpes zoster, genital herpes, and chickenpox.[L7315] An acyclovir topical ointment is indicated to treat initial genital herpes and limited non-life-threatening mucocutaneous herpes simplex in immunocompromised patients.[L7318] An acyclovir cream with hydrocortisone is indicated to treat recurrent herpes labialis, and shortening lesion healing time in patients 6 years and older.[L7321] An acyclovir buccal tablet is indicated for the treatment of recurrent herpes labialis.[L7324] An acyclovir ophthalmic ointment is indicated to treat acute herpetic keratitis.[L7327]
DB09299Tenofovir alafenamideTenofovir alafenamide is indicated for the treatment of chronic hepatitis B in adult patients with compensated liver disease.[L6241] In combination with [emtricitabine] and other antiretrovirals, it is indicated for the treatment of HIV-1 infection in patients with a weight higher than 35 kg. When combined with antiretrovirals other than protease inhibitors that require a CYP3A inhibitor, it can be used in pediatric patients weighing between 25 and 35 kg.[L4388] In the combination product with emtricitabine and [bictegravir], tenofovir alafenamide is considered as a complete regimen for the treatment of HIV-1 infection in treatment-naive patients or in patients virologically suppressed for at least 3 months with no history of treatment failure.[L6277] Additionally, the combination product including [elvitegravir], [cobicistat], emtricitabine and tenofovir alafenamide and the combination product including emtricitabine, [rilpivirine] and tenofovir alafenamide can be used in the treatment of HIV-1 infection in patients older than 12 years with no previous antiretroviral therapy history or who are virologically suppressed for at least 6 months with no history of treatment failure.[L6280] Lastly, the combination product including [darunavir], cobicistat, emtricitabine, and tenofovir alafenamide is indicated for the treatment of HIV-1 infection in adults without prior antiretroviral therapy or in patients virologically suppressed for 6 months and no reported resistance to darunavir or tenofovir.[L6283]
DB00300Tenofovir disoproxilTenofovir is indicated in combination with other antiretroviral agents for the management of HIV-1 infection in adults and pediatric patients 2 years of age and older. It is also indicated for the treatment of chronic hepatitis B in adults and pediatric patients 12 years of age and older [FDA label]. This drug is also a component of multiple products used for the management of HIV-1 infection [F3418], [F3421]. Safety and effectiveness of tenofovir disoproxil in pediatric patients younger than 2 years of age has not been established to this date [FDA label].
DB00917DinoprostoneFor the termination of pregnancy during the second trimester (from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period), as well as for evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first day of the last normal menstrual period. Also used in the management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole). Other indications include improving the cervical inducibility (cervical "ripening") in pregnant women at or near term with a medical or obstetrical need for labor induction, and the management of postpartum hemorrhage.
DB01327CefazolinMainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. May be used for surgical prophylaxis; if required metronidazole may be added to cover B. fragilis.
DB00567CephalexinCephalexin is indicated for the treatment of certain infections caused by susceptible bacteria.[Label,L6550,L6553] These infections include respiratory tract infections, otitis media, skin and skin structure infections, bone infections, and genitourinary tract infections.[Label,L6550,L6553]
DB04348Taurocholic AcidNot Available
DB02527Cyclic adenosine monophosphateNot Available
DB00709LamivudineFor the treatment of HIV infection and chronic hepatitis B (HBV).
DB01137LevofloxacinFor the treatment of bacterial conjunctivitis caused by susceptible strains of the following organisms: Corynebacterium species, Staphylococus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus (Groups C/F/G), Viridans group streptococci, Acinetobacter lwoffii, Haemophilus influenzae, Serratia marcescens.
DB00365GrepafloxacinFor treatment of adults with mild to moderate infections caused by susceptible strains of Haemophilus influenzae, Streptococcus pneumoniae, or Moraxella catarrhalis.
DB00649StavudineFor the treatment of human immunovirus (HIV) infections.
DB00943ZalcitabineFor the treatment of Human immunovirus (HIV) infections in conjunction with other antivirals.
DB00900DidanosineFor use, in combination with other antiretroviral agents, in the treatment of HIV-1 infection in adults.
DB01414CefacetrileCefacetrile is a broad-spectrum first generation cephalosporin antibiotic effective in Gram-positive and Gram-negative bacterial infections.
DB01197CaptoprilFor the treatment of essential or renovascular hypertension (usually administered with other drugs, particularly thiazide diuretics). May be used to treat congestive heart failure in combination with other drugs (e.g. cardiac glycosides, diuretics, β-adrenergic blockers). May improve survival in patients with left ventricular dysfunction following myocardial infarction. May be used to treat nephropathy, including diabetic nephropathy.
DB00535CefdinirCefdinir is indicated to treat acute bacterial otitis media, acute maxillary sinusitis, community-acquired (CA) pneumonia, acute bacterial exacerbations of chronic bronchitis, pharyngitis/tonsillitis, and uncomplicated skin and skin structure infections in children and adults.[L7330,A180739] The organisms susceptible to cefdinir have been listed below in addition to their associated clinical condition that may be treated with cefdinir.[L7330] Various beta-lactamase producing organisms may be treated, as indicated in certain sections below. **Respiratory** Acute bacterial exacerbations of chronic bronchitis caused by Haemophilus influenzae, Haemophilus parainfluenzae, Streptococcus pneumoniae (penicillin-susceptible only), and Moraxella catarrhalis Community-acquired pneumonia caused by Haemophilus influenzae, Haemophilus parainfluenzae, Streptococcus pneumoniae (penicillin-susceptible only), and Moraxella catarrhalis **Ear, nose, and throat** Acute bacterial otitis media caused by Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae (penicillin-susceptible only) Tonsillitis caused by Streptococcus pyogenes Pharyngitis caused by Streptococcus pyogenes Acute maxillary sinusitis caused by Haemophilus pneumoniae and Streptococcus pneumoniae (penicillin-susceptible only), and Moraxella catarrhalis **Skin and skin structure infections** Uncomplicated skin and skin structure infections caused by Staphylococcus aureus and Streptococcus pyogenes
DB00229CefotiamFor treatment of severe infections caused by susceptible bacteria.
DB01415CeftibutenIndicated for the treatment of acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsilitis.
DB01332CeftizoximeFor the treatment of infections due to susceptible strains of microorganisms.
DB09008CefaloridineNot Available
DB00155L-CitrullineUsed for nutritional supplementation, also for treating dietary shortage or imbalance.
DB12243EdaravoneIndicated for improving neurological symptoms and damage from acute ischemic stroke and delaying disease progression of ALS.
DB08846Ellagic AcidEllagic acid is being investigated for use in follicular lymphoma, brain injury in intrauterine growth restricted babies, obese adolescents, and solar lentigines.
DB00693FluoresceinFor diagnostic imaging. Primarily indicated in diagnostic fluorescein angiography or angioscopy of the fundus and of the iris vasculature.
DB00328IndometacinOral indometacin is indicated for symptomatic management of moderate to severe rheumatoid arthritis including acute flares of chronic disease, moderate to severe ankylosing spondylitis, moderate to severe osteoarthritis, acute painful shoulder (bursitis and/or tendinitis) and acute gouty arthritis.[A177871,L6778] Intravenous indometacin is indicated to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants weighing between 500 and 1750 g when after 48 hours usual medical management (e.g., fluid restriction, diuretics, digitalis, respiratory support, etc.) is ineffective.[F4600]
DB00770AlprostadilFor palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. Also for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.
DB00863RanitidineThis drug is used alone or with concomitant antacids for the following conditions [FDA label]: **Duodenal ulcer** Treatment of active duodenal ulcer (short-term), maintenance therapy of duodenal ulcers after healing (reduced dose) **Pathological hypersecretion of gastric acid** Zollinger-Ellison syndrome, systemic mastocytosis, and other conditions causing gastric acid hypersecretion **Gastric ulcer** Short term treatment of active gastric ulcer (benign), maintenance of healing after gastric acid ulcer therapy (reduced dose) **Other conditions**: Treatment of GERD symptoms (symptoms usually improve within 24 hours), treatment of erosive esophagitis (endoscopically diagnosed) and maintenance of healing [FDA label]
DB09298SilibininCurrently being tested as a treatment of severe intoxications with hepatotoxic substances, such as death cap (Amanita phalloides) poisoning.
DB00432TrifluridineTrifluridine is used for the treatment of primay keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus, types 1 and 2 in ophthalmic solutions. Trifluridine, in combination with tipiracil as oral tablets, is indicated for the treatment of adult patients with metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type, an anti-EGFR therapy [FDA Label].
DB00495ZidovudineUsed in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections.
DB01606TazobactamTazobactam is used in combination with piperacillin or ceftolozane to broaden the spectrum of piperacillin antibacterial action, treating susceptible infections. As with any other antibiotic, tazobactam should only be used for infections that are either proven or strongly suspected to be susceptible to the tazobactam containing drug. **Tazobactam-piperacillin** When combined with piperacillin, it is used to treat a variety of infections, including those caused by aerobic and facultative gram-positive and gram-negative bacteria, in addition to gram-positive and gram-negative anaerobes. Some examples of infections treated with piperacillin-tazobactam include cellulitis, diabetic foot infections, appendicitis, and postpartum endometritis infections.[L4417] Certain gram-negative bacilli infections with beta-lactamase producing organisms cannot be treated with piperacillin-tazobactam, due to a gene mutation conferring antibiotic resistance.[A179266] **Tazobactam-ceftolozane** Tazobactam-ceftolozane combined with metronidazole is used to treat complicated urinary tract infections (UTI) and complicated intra-abdominal infections, as well as ventilator-associated bacterial pneumonia and hospital-acquired bacterial pneumonia.[FDA label]. This combination increases efficacy against infections with gram-negative bacilli.[A7657]
DrugDrug NameTargetType
DB00345Aminohippuric acidSolute carrier family 22 member 2transporter
DB00345Aminohippuric acidSolute carrier family 22 member 5transporter
DB00345Aminohippuric acidSolute carrier family 22 member 6transporter
DB00345Aminohippuric acidSolute carrier family 22 member 8transporter
DB00345Aminohippuric acidCanalicular multispecific organic anion transporter 1transporter
DB00345Aminohippuric acidSolute carrier family 22 member 4transporter
DB00345Aminohippuric acidSolute carrier family 22 member 11transporter
DB00345Aminohippuric acidSolute carrier organic anion transporter family member 3A1transporter
DB00345Aminohippuric acidSolute carrier organic anion transporter family member 1B1transporter
DB00345Aminohippuric acidMultidrug resistance-associated protein 1transporter
DB00345Aminohippuric acidSolute carrier organic anion transporter family member 1A2transporter
DB00345Aminohippuric acidMonocarboxylate transporter 1transporter
DB00345Aminohippuric acidSolute carrier family 22 member 7transporter
DB03553Glutaric AcidAspartate aminotransferasetarget
DB03553Glutaric AcidBranched-chain-amino-acid aminotransferasetarget
DB03553Glutaric AcidGlutamate decarboxylase alphatarget
DB03553Glutaric AcidSolute carrier family 22 member 6transporter
DB03553Glutaric AcidSolute carrier family 22 member 8transporter
DB03553Glutaric AcidSolute carrier family 22 member 11transporter
DB03553Glutaric AcidSolute carrier family 22 member 7transporter
DB00369CidofovirDNA polymerase catalytic subunittarget
DB00369CidofovirSolute carrier family 22 member 6transporter
DB00369CidofovirThymidine phosphorylaseenzyme
DB00718Adefovir dipivoxilDNA polymerase/reverse transcriptasetarget
DB00718Adefovir dipivoxilSolute carrier family 22 member 6transporter
DB00718Adefovir dipivoxilMultidrug resistance-associated protein 4transporter
DB00718Adefovir dipivoxilMultidrug resistance-associated protein 5transporter
DB00718Adefovir dipivoxilSolute carrier family 22 member 3transporter
DB00718Adefovir dipivoxilAdenylate kinase 2, mitochondrialenzyme
DB00718Adefovir dipivoxilAdenylate kinase 4, mitochondrialenzyme
DB00718Adefovir dipivoxilNucleoside diphosphate kinase Aenzyme
DB00718Adefovir dipivoxilNucleoside diphosphate kinase Benzyme
DB00501CimetidineHistamine H2 receptortarget
DB00501CimetidineCytochrome P450 1A2enzyme
DB00501CimetidineCytochrome P450 2D6enzyme
DB00501CimetidineCytochrome P450 2C19enzyme
DB00501CimetidineCytochrome P450 3A4enzyme
DB00501CimetidineCytochrome P450 3A5enzyme
DB00501CimetidineCytochrome P450 3A7enzyme
DB00501CimetidineMultidrug resistance protein 1transporter
DB00501CimetidineSolute carrier family 22 member 2transporter
DB00501CimetidineSolute carrier family 22 member 1transporter
DB00501CimetidineSolute carrier family 22 member 3transporter
DB00501CimetidineSolute carrier family 22 member 5transporter
DB00501CimetidineSolute carrier family 22 member 6transporter
DB00501CimetidineSolute carrier family 22 member 8transporter
DB00501CimetidineMultidrug and toxin extrusion protein 1transporter
DB00501CimetidineSolute carrier family 22 member 4transporter
DB00501CimetidineSolute carrier family 22 member 11transporter
DB00501CimetidineSolute carrier family 22 member 7transporter
DB00501CimetidineCytochrome P450 11B1, mitochondrialenzyme
DB00501CimetidineCytochrome P450 2C8enzyme
DB00501CimetidineCytochrome P450 2C9enzyme
DB00501CimetidineCytochrome P450 2E1enzyme
DB00501CimetidineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00501CimetidineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB00501CimetidineBile salt export pumptransporter
DB00501CimetidineMultidrug and toxin extrusion protein 2transporter
DB00787AcyclovirDNA polymerase catalytic subunittarget
DB00787AcyclovirDNA polymerase catalytic subunittarget
DB00787AcyclovirThymidine kinasetarget
DB00787AcyclovirSolute carrier family 22 member 1transporter
DB00787AcyclovirSolute carrier family 22 member 6transporter
DB00787AcyclovirSolute carrier family 22 member 8transporter
DB00787AcyclovirIleal sodium/bile acid cotransportertransporter
DB00787AcyclovirMultidrug and toxin extrusion protein 1transporter
DB00787AcyclovirMultidrug and toxin extrusion protein 2transporter
DB00787AcyclovirThymidine kinaseenzyme
DB00787AcyclovirGuanylate kinaseenzyme
DB00787AcyclovirNucleoside diphosphokinaseenzyme
DB00787AcyclovirPyruvate Kinasesenzyme
DB00787AcyclovirCreatine Kinasesenzyme
DB00787AcyclovirPhosphoglycerate Kinasesenzyme
DB00787AcyclovirSuccinyl-CoA Synthetasesenzyme
DB00787AcyclovirPhosphoenolpyruvate Carboxykinasesenzyme
DB00787AcyclovirAdenylosuccinate Synthetasesenzyme
DB00787AcyclovirSerum albumincarrier
DB09299Tenofovir alafenamideReverse transcriptase/RNaseHtarget
DB09299Tenofovir alafenamideMultidrug resistance protein 1transporter
DB09299Tenofovir alafenamideMultidrug resistance-associated protein 4transporter
DB09299Tenofovir alafenamideSolute carrier family 22 member 6transporter
DB09299Tenofovir alafenamideSolute carrier family 22 member 8transporter
DB09299Tenofovir alafenamideLysosomal protective proteinenzyme
DB09299Tenofovir alafenamideLiver carboxylesterase 1enzyme
DB09299Tenofovir alafenamideATP-binding cassette sub-family G member 2transporter
DB09299Tenofovir alafenamideSolute carrier organic anion transporter family member 1B1transporter
DB09299Tenofovir alafenamideSolute carrier organic anion transporter family member 1B3transporter
DB09299Tenofovir alafenamideReverse transcriptasetarget
DB09299Tenofovir alafenamideDNA polymerasetarget
DB09299Tenofovir alafenamideSerum albumincarrier
DB09299Tenofovir alafenamideCytochrome P450 3A4enzyme
DB09299Tenofovir alafenamideAdenylate kinase isoenzyme 1enzyme
DB09299Tenofovir alafenamideAdenylate kinase 2, mitochondrialenzyme
DB09299Tenofovir alafenamideNucleoside diphosphate kinase Aenzyme
DB09299Tenofovir alafenamideNucleoside diphosphate kinase Benzyme
DB00300Tenofovir disoproxilReverse transcriptase/RNaseHtarget
DB00300Tenofovir disoproxilSolute carrier family 22 member 6transporter
DB00300Tenofovir disoproxilSolute carrier family 22 member 8transporter
DB00300Tenofovir disoproxilMultidrug resistance-associated protein 7transporter
DB00300Tenofovir disoproxilMultidrug resistance-associated protein 4transporter
DB00300Tenofovir disoproxilCanalicular multispecific organic anion transporter 1transporter
DB00300Tenofovir disoproxilAdenylate kinase 2, mitochondrialenzyme
DB00300Tenofovir disoproxilAdenylate kinase 4, mitochondrialenzyme
DB00300Tenofovir disoproxilMultidrug resistance protein 1transporter
DB00300Tenofovir disoproxilNucleoside diphosphokinaseenzyme
DB00300Tenofovir disoproxilCreatine Kinasesenzyme
DB00300Tenofovir disoproxilDNA polymerase/reverse transcriptasetarget
DB00917DinoprostoneProstaglandin E2 receptor EP2 subtypetarget
DB00917DinoprostoneProstaglandin E2 receptor EP1 subtypetarget
DB00917DinoprostoneProstaglandin E2 receptor EP4 subtypetarget
DB00917DinoprostoneProstaglandin E2 receptor EP3 subtypetarget
DB00917DinoprostoneSolute carrier family 22 member 2transporter
DB00917DinoprostoneMultidrug resistance-associated protein 5transporter
DB00917DinoprostoneSolute carrier family 22 member 6transporter
DB00917DinoprostoneSolute carrier family 22 member 8transporter
DB00917DinoprostoneSolute carrier family 22 member 11transporter
DB00917DinoprostoneSolute carrier family 22 member 7transporter
DB00917DinoprostoneMultidrug resistance-associated protein 4transporter
DB00917DinoprostoneSolute carrier organic anion transporter family member 2B1transporter
DB00917DinoprostoneSolute carrier organic anion transporter family member 1A2transporter
DB00917DinoprostoneOrganic solute transporter subunit alphatransporter
DB00917DinoprostoneOrganic solute transporter subunit betatransporter
DB00917DinoprostoneSolute carrier organic anion transporter family member 2A1transporter
DB00917DinoprostoneSolute carrier organic anion transporter family member 4A1transporter
DB00917DinoprostoneSolute carrier organic anion transporter family member 1C1transporter
DB00917DinoprostoneSolute carrier organic anion transporter family member 3A1transporter
DB00917DinoprostoneSolute carrier organic anion transporter family member 1B1transporter
DB00917DinoprostoneCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB00917DinoprostoneCytochrome P450 19A1enzyme
DB00917DinoprostoneProstaglandin D2 receptor 2target
DB01327CefazolinSerum paraoxonase/arylesterase 1target
DB01327CefazolinSerum albumincarrier
DB01327CefazolinSolute carrier family 22 member 6transporter
DB01327CefazolinSolute carrier family 22 member 8transporter
DB01327CefazolinSolute carrier family 22 member 11transporter
DB01327CefazolinPenicillin-binding protein 1Atarget
DB01327CefazolinPenicillin-binding protein 1Btarget
DB01327CefazolinPenicillin-binding protein 2target
DB01327CefazolinPenicillin-binding protein 1Ctarget
DB01327CefazolinPeptidoglycan synthase FtsItarget
DB01327CefazolinMultidrug resistance-associated protein 4transporter
DB01327CefazolinThiopurine S-methyltransferaseenzyme
DB01327CefazolinInterleukin-15target
DB01327CefazolinInterleukin-2target
DB00567CephalexinSerum albumincarrier
DB00567CephalexinSolute carrier family 22 member 5transporter
DB00567CephalexinSolute carrier family 15 member 1transporter
DB00567CephalexinSolute carrier family 15 member 2transporter
DB00567CephalexinSolute carrier family 22 member 6transporter
DB00567CephalexinSolute carrier family 22 member 8transporter
DB00567CephalexinMultidrug and toxin extrusion protein 1transporter
DB00567CephalexinPenicillin-binding protein 3target
DB00567CephalexinPenicillin-binding protein 2atarget
DB00567CephalexinPenicillin-binding protein 1btarget
DB00567CephalexinPenicillin-binding protein 1Atarget
DB00567CephalexinPenicillin-binding protein 2Btarget
DB04348Taurocholic AcidBile salt-activated lipasetarget
DB04348Taurocholic AcidGastrotropintarget
DB04348Taurocholic AcidBile salt export pumptransporter
DB04348Taurocholic AcidMultidrug resistance-associated protein 1transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 1A2transporter
DB04348Taurocholic AcidIleal sodium/bile acid cotransportertransporter
DB04348Taurocholic AcidCanalicular multispecific organic anion transporter 1transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 1B1transporter
DB04348Taurocholic AcidCanalicular multispecific organic anion transporter 2transporter
DB04348Taurocholic AcidMultidrug resistance-associated protein 4transporter
DB04348Taurocholic AcidMultidrug resistance protein 1transporter
DB04348Taurocholic AcidSolute carrier family 22 member 6transporter
DB04348Taurocholic AcidMultidrug resistance-associated protein 7transporter
DB04348Taurocholic AcidSolute carrier family 22 member 8transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 4A1transporter
DB04348Taurocholic AcidATP-binding cassette sub-family C member 11transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 1C1transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 3A1transporter
DB04348Taurocholic AcidATP-binding cassette sub-family G member 2transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 2B1transporter
DB04348Taurocholic AcidMonocarboxylate transporter 1transporter
DB04348Taurocholic AcidSodium/bile acid cotransportertransporter
DB04348Taurocholic AcidOrganic solute transporter subunit alphatransporter
DB04348Taurocholic AcidOrganic solute transporter subunit betatransporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 1B3transporter
DB04348Taurocholic AcidCystine/glutamate transportertransporter
DB04348Taurocholic AcidBile acid receptortarget
DB02527Cyclic adenosine monophosphatePotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2target
DB02527Cyclic adenosine monophosphatecAMP-dependent protein kinase type I-alpha regulatory subunittarget
DB02527Cyclic adenosine monophosphatecAMP-dependent protein kinase type II-beta regulatory subunittarget
DB02527Cyclic adenosine monophosphatecAMP-activated global transcriptional regulator CRPtarget
DB02527Cyclic adenosine monophosphateAdenylate cyclasetarget
DB02527Cyclic adenosine monophosphateCyclic nucleotide-gated potassium channel mll3241target
DB02527Cyclic adenosine monophosphateMultidrug resistance-associated protein 4transporter
DB02527Cyclic adenosine monophosphateMultidrug resistance-associated protein 5transporter
DB02527Cyclic adenosine monophosphateATP-binding cassette sub-family C member 11transporter
DB02527Cyclic adenosine monophosphateSolute carrier family 22 member 6transporter
DB02527Cyclic adenosine monophosphateSolute carrier family 22 member 8transporter
DB02527Cyclic adenosine monophosphateSolute carrier family 22 member 7transporter
DB00709LamivudineDNAtarget
DB00709LamivudineProtein Ptarget
DB00709LamivudineMultidrug resistance-associated protein 1transporter
DB00709LamivudineSolute carrier family 22 member 6transporter
DB00709LamivudineATP-binding cassette sub-family G member 2transporter
DB00709LamivudineReverse transcriptase/RNaseHtarget
DB00709LamivudineSolute carrier family 22 member 1transporter
DB00709LamivudineSolute carrier family 22 member 2transporter
DB00709LamivudineSolute carrier family 22 member 3transporter
DB00709LamivudineDeoxycytidine kinaseenzyme
DB00709LamivudineUMP-CMP kinaseenzyme
DB00709LamivudinePhosphoglycerate kinase 1enzyme
DB00709LamivudineNucleoside diphosphate kinase Aenzyme
DB00709LamivudineNucleoside diphosphate kinase Benzyme
DB00709LamivudineCholine-phosphate cytidylyltransferase Aenzyme
DB00709LamivudineEthanolamine-phosphate cytidylyltransferaseenzyme
DB00709LamivudineMultidrug resistance protein 1transporter
DB00709LamivudineMultidrug resistance-associated protein 4transporter
DB00709LamivudineCanalicular multispecific organic anion transporter 2transporter
DB00709LamivudineCanalicular multispecific organic anion transporter 1transporter
DB00709Lamivudine5'(3')-deoxyribonucleotidase, cytosolic typeenzyme
DB00709LamivudineSerum albumincarrier
DB01137LevofloxacinDNA gyrase subunit Atarget
DB01137LevofloxacinDNA topoisomerase 4 subunit Atarget
DB01137LevofloxacinDNA topoisomerase 2-alphatarget
DB01137LevofloxacinCytochrome P450 1A2enzyme
DB01137LevofloxacinSolute carrier family 22 member 2transporter
DB01137LevofloxacinMultidrug resistance protein 1transporter
DB01137LevofloxacinSolute carrier family 22 member 4transporter
DB01137LevofloxacinSolute carrier family 22 member 6transporter
DB01137LevofloxacinCytochrome P450 3A4enzyme
DB01137LevofloxacinMultidrug and toxin extrusion protein 1transporter
DB01137LevofloxacinMultidrug and toxin extrusion protein 2transporter
DB00365GrepafloxacinDNA gyrase subunit Atarget
DB00365GrepafloxacinDNA topoisomerase 4 subunit Atarget
DB00365GrepafloxacinCytochrome P450 3A4enzyme
DB00365GrepafloxacinCytochrome P450 1A2enzyme
DB00365GrepafloxacinSolute carrier family 22 member 2transporter
DB00365GrepafloxacinSolute carrier family 22 member 5transporter
DB00365GrepafloxacinCanalicular multispecific organic anion transporter 1transporter
DB00365GrepafloxacinMultidrug resistance protein 1transporter
DB00365GrepafloxacinMultidrug resistance-associated protein 1transporter
DB00365GrepafloxacinSolute carrier family 22 member 6transporter
DB00649StavudineSolute carrier family 22 member 6transporter
DB00649StavudineReverse transcriptase/RNaseHtarget
DB00649StavudineSodium/nucleoside cotransporter 1transporter
DB00649StavudineSerum albumincarrier
DB00943ZalcitabineDeoxycytidine kinaseenzyme
DB00943ZalcitabineSolute carrier family 22 member 6transporter
DB00943ZalcitabineSolute carrier family 22 member 7transporter
DB00943ZalcitabineReverse transcriptase/RNaseHtarget
DB00943ZalcitabineEquilibrative nucleoside transporter 1transporter
DB00943ZalcitabineEquilibrative nucleoside transporter 2transporter
DB00943ZalcitabineSerum albumincarrier
DB00900DidanosineSolute carrier family 22 member 6transporter
DB00900DidanosinePurine nucleoside phosphorylasetarget
DB00900DidanosineReverse transcriptase/RNaseHtarget
DB00900DidanosineEquilibrative nucleoside transporter 1transporter
DB00900DidanosineEquilibrative nucleoside transporter 2transporter
DB00900DidanosineSerum albumincarrier
DB01414CefacetrilePenicillin-binding protein 1Atarget
DB01414CefacetrilePenicillin-binding protein 1Btarget
DB01414CefacetrileSolute carrier family 22 member 6transporter
DB01414CefacetrileSolute carrier family 22 member 8transporter
DB01197CaptoprilAngiotensin-converting enzymetarget
DB01197CaptoprilCytochrome P450 2D6enzyme
DB01197CaptoprilSerum albumincarrier
DB01197Captopril72 kDa type IV collagenasetarget
DB01197CaptoprilMatrix metalloproteinase-9target
DB01197CaptoprilMultidrug resistance protein 1transporter
DB01197CaptoprilSolute carrier family 15 member 1transporter
DB01197CaptoprilSolute carrier family 22 member 6transporter
DB01197CaptoprilLeukotriene A-4 hydrolasetarget
DB01197CaptoprilB1 bradykinin receptortarget
DB00535CefdinirMyeloperoxidasetarget
DB00535CefdinirPenicillin-binding protein 2target
DB00535CefdinirPBP3target
DB00535CefdinirSolute carrier family 22 member 5transporter
DB00535CefdinirSolute carrier family 15 member 1transporter
DB00535CefdinirSolute carrier family 15 member 2transporter
DB00535CefdinirSolute carrier family 22 member 6transporter
DB00535CefdinirSolute carrier family 22 member 8transporter
DB00535CefdinirPeptidoglycan transpeptidasetarget
DB00229CefotiamPenicillin-binding protein 1Atarget
DB00229CefotiamSolute carrier family 22 member 6transporter
DB00229CefotiamSolute carrier family 22 member 8transporter
DB01415CeftibutenSolute carrier family 15 member 1transporter
DB01415CeftibutenSolute carrier family 15 member 2transporter
DB01415CeftibutenPeptidoglycan synthase FtsItarget
DB01415CeftibutenPenicillin-binding protein 1Atarget
DB01415CeftibutenPenicillin-binding protein 1Btarget
DB01415CeftibutenPenicillin-binding protein 2target
DB01415CeftibutenSolute carrier family 22 member 6transporter
DB01415CeftibutenSolute carrier family 22 member 8transporter
DB01332CeftizoximeSolute carrier family 15 member 1transporter
DB01332CeftizoximePeptidoglycan synthase FtsItarget
DB01332CeftizoximePenicillin-binding protein 1Atarget
DB01332CeftizoximePenicillin-binding protein 1Btarget
DB01332CeftizoximeMecA PBP2' (penicillin binding protein 2')target
DB01332CeftizoximeSolute carrier family 22 member 6transporter
DB01332CeftizoximeSolute carrier family 22 member 8transporter
DB09008CefaloridineSolute carrier family 22 member 6transporter
DB09008CefaloridineSolute carrier family 22 member 8transporter
DB00155L-CitrullineNitric oxide synthase, endothelialtarget
DB00155L-CitrullineArgininosuccinate synthasetarget
DB00155L-CitrullineN(G),N(G)-dimethylarginine dimethylaminohydrolase 2target
DB00155L-CitrullineArgininosuccinate synthetase, isoform CRA_atarget
DB00155L-CitrullineN(G),N(G)-dimethylarginine dimethylaminohydrolase 1target
DB00155L-CitrullineOrnithine carbamoyltransferase, mitochondrialtarget
DB00155L-CitrullineNitric oxide synthase, braintarget
DB00155L-CitrullineNitric oxide synthase, inducibletarget
DB00155L-CitrullineProtein-arginine deiminase type-4target
DB00155L-CitrullineProtein-arginine deiminase type-6target
DB00155L-CitrullineProtein-arginine deiminase type-1target
DB00155L-CitrullineProtein-arginine deiminase type-3target
DB00155L-CitrullineProtein-arginine deiminase type-2target
DB00155L-CitrullineSolute carrier family 22 member 6transporter
DB12243EdaravoneSolute carrier family 22 member 6transporter
DB12243EdaravoneSolute carrier family 22 member 8transporter
DB08846Ellagic AcidSolute carrier family 22 member 6transporter
DB08846Ellagic AcidSolute carrier family 22 member 11transporter
DB08846Ellagic AcidCytochrome P450 1A1enzyme
DB08846Ellagic AcidCytochrome P450 2E1enzyme
DB08846Ellagic AcidCarbonic anhydrase 1target
DB08846Ellagic AcidCarbonic anhydrase 2target
DB08846Ellagic AcidCarbonic anhydrase 3target
DB08846Ellagic AcidCarbonic anhydrase 4target
DB08846Ellagic AcidCarbonic anhydrase 5A, mitochondrialtarget
DB08846Ellagic AcidCarbonic anhydrase 5B, mitochondrialtarget
DB08846Ellagic AcidCarbonic anhydrase 6target
DB08846Ellagic AcidCarbonic anhydrase 7target
DB08846Ellagic AcidCarbonic anhydrase 9target
DB08846Ellagic AcidCarbonic anhydrase 12target
DB08846Ellagic AcidCarbonic anhydrase 14target
DB08846Ellagic AcidCasein kinase II subunit alphatarget
DB08846Ellagic AcidcAMP-dependent protein kinase catalytic subunit alphatarget
DB08846Ellagic AcidProtein kinase C alpha typetarget
DB08846Ellagic AcidProtein kinase C beta typetarget
DB08846Ellagic AcidTyrosine-protein kinase SYKtarget
DB08846Ellagic AcidSqualene monooxygenasetarget
DB00693FluoresceinIg kappa chain V-II region RPMI 6410target
DB00693FluoresceinDNAtarget
DB00693FluoresceinSolute carrier family 22 member 6transporter
DB00693FluoresceinBile salt export pumptransporter
DB00693FluoresceinMultidrug resistance-associated protein 1transporter
DB00693FluoresceinCytochrome P450 1A1enzyme
DB00328IndometacinProstaglandin G/H synthase 1target
DB00328IndometacinProstaglandin G/H synthase 2target
DB00328IndometacinCytochrome P450 2C19enzyme
DB00328IndometacinUDP-glucuronosyltransferase 1-9enzyme
DB00328IndometacinPhospholipase A2, membrane associatedtarget
DB00328IndometacinProstaglandin reductase 2target
DB00328IndometacinLactoylglutathione lyasetarget
DB00328IndometacinProstaglandin D2 receptor 2target
DB00328IndometacinPeroxisome proliferator-activated receptor gammatarget
DB00328IndometacinSerum albumincarrier
DB00328IndometacinCanalicular multispecific organic anion transporter 2transporter
DB00328IndometacinMultidrug resistance-associated protein 4transporter
DB00328IndometacinMultidrug resistance-associated protein 6transporter
DB00328IndometacinMultidrug resistance protein 1transporter
DB00328IndometacinMultidrug resistance-associated protein 1transporter
DB00328IndometacinSolute carrier organic anion transporter family member 1A2transporter
DB00328IndometacinSolute carrier family 22 member 6transporter
DB00328IndometacinSolute carrier family 22 member 8transporter
DB00328IndometacinCanalicular multispecific organic anion transporter 1transporter
DB00328IndometacinATP-binding cassette sub-family C member 11transporter
DB00328IndometacinSolute carrier family 22 member 11transporter
DB00328IndometacinSodium/bile acid cotransportertransporter
DB00328IndometacinSolute carrier family 22 member 7transporter
DB00328IndometacinCytochrome P450 2C9enzyme
DB00328IndometacinUDP-glucuronosyltransferase 1-1enzyme
DB00328IndometacinLiver carboxylesterase 1enzyme
DB00328IndometacinUDP-glucuronosyltransferase 2B7enzyme
DB00328IndometacinPeroxisome proliferator-activated receptor alphatarget
DB00328IndometacinAldo-keto reductase family 1 member C3target
DB00328IndometacinSolute carrier organic anion transporter family member 1B1transporter
DB00328IndometacinBile salt export pumptransporter
DB00770AlprostadilProstaglandin E2 receptor EP2 subtypetarget
DB00770AlprostadilProstaglandin E2 receptor EP1 subtypetarget
DB00770AlprostadilMultidrug resistance-associated protein 5transporter
DB00770AlprostadilSolute carrier organic anion transporter family member 2B1transporter
DB00770AlprostadilSolute carrier organic anion transporter family member 3A1transporter
DB00770AlprostadilMultidrug resistance-associated protein 4transporter
DB00770AlprostadilSolute carrier organic anion transporter family member 2A1transporter
DB00770AlprostadilProstaglandin D2 receptor 2target
DB00770AlprostadilSolute carrier family 22 member 6transporter
DB00863RanitidineHistamine H2 receptortarget
DB00863RanitidineCytochrome P450 1A2enzyme
DB00863RanitidineCytochrome P450 2D6enzyme
DB00863RanitidineSolute carrier family 22 member 1transporter
DB00863RanitidineMultidrug resistance protein 1transporter
DB00863RanitidineSolute carrier family 22 member 8transporter
DB00863RanitidineCytochrome P450 3A4enzyme
DB00863RanitidineAcetylcholinesterasetarget
DB00863RanitidineSolute carrier family 22 member 2transporter
DB00863RanitidineCholinesterasetarget
DB09298SilibininSolute carrier family 22 member 6transporter
DB09298SilibininUDP-glucuronosyltransferase 1-1enzyme
DB09298SilibininSolute carrier organic anion transporter family member 1B1transporter
DB09298SilibininSolute carrier organic anion transporter family member 1B3transporter
DB09298SilibininSolute carrier organic anion transporter family member 2B1transporter
DB00432TrifluridineThymidylate synthasetarget
DB00432TrifluridineDNAtarget
DB00432TrifluridineThymidine kinase, cytosolicenzyme
DB00432TrifluridineThymidine phosphorylaseenzyme
DB00432TrifluridineSolute carrier family 22 member 6transporter
DB00432TrifluridineSodium/nucleoside cotransporter 1transporter
DB00432TrifluridineEquilibrative nucleoside transporter 1transporter
DB00432TrifluridineEquilibrative nucleoside transporter 2transporter
DB00432TrifluridineSerum albumincarrier
DB00495ZidovudineSerum albumincarrier
DB00495ZidovudineCytochrome P450 2A6enzyme
DB00495ZidovudineCytochrome P450 2C8enzyme
DB00495ZidovudineCytochrome P450 2C9enzyme
DB00495ZidovudineCytochrome P450 3A4enzyme
DB00495ZidovudineReverse transcriptase/RNaseHtarget
DB00495ZidovudineSolute carrier family 22 member 2transporter
DB00495ZidovudineSolute carrier family 22 member 6transporter
DB00495ZidovudineSolute carrier family 22 member 7transporter
DB00495ZidovudineSolute carrier family 22 member 8transporter
DB00495ZidovudineSolute carrier family 22 member 11transporter
DB00495ZidovudineSodium/nucleoside cotransporter 1transporter
DB00495ZidovudineEquilibrative nucleoside transporter 2transporter
DB00495ZidovudineMultidrug resistance protein 1transporter
DB00495ZidovudineMultidrug resistance-associated protein 4transporter
DB00495ZidovudineMultidrug resistance-associated protein 5transporter
DB00495ZidovudineATP-binding cassette sub-family G member 2transporter
DB00495ZidovudineTelomerase reverse transcriptasetarget
DB00495ZidovudineThymidine kinase, cytosolicenzyme
DB00495ZidovudineUDP-glucuronosyltransferase 2B7enzyme
DB00495ZidovudineUDP-glucuronosyltransferase 1-1enzyme
DB01606TazobactamBeta-lactamase TEMtarget
DB01606TazobactamSolute carrier family 22 member 6transporter
DB01606TazobactamSolute carrier family 22 member 8transporter
DB01606TazobactamBeta-lactamase Ohio-1target
DB01606TazobactamBeta-lactamase SHV-1target