Thyroxine-binding globulin substrates

Name
Thyroxine-binding globulin substrates
Accession Number
DBCAT004601
Description
Not Available
Drugs
DrugDrug Description
LiothyronineA thyroid hormone replacement therapy used to treat hypothyroidism, to suppress TSH, and to help in the diagnosis of hyperthyroidism.
Liothyronine I-131Liothyronine I-131 has been used in trials studying the treatment of Tricuspid Atresia and Heart Defects, Congenital.
LiotrixMay be used to treat primary, secondary or tertiary hypothyroidism. May also be used to suppress thyroid stimulating hormone (TSH) secretion in patients with simple (nontoxic) goiter, subacute or chronic...
LevothyroxineA synthetic T4 hormone used to treat hypothyroidism that can be used along with surgery and radioiodine therapy to manage thyrotropin-dependent well-differentiated thyroid cancer.
FurosemideA loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension.
MephenytoinA phenylhydantoin used to treat refractory partial epilepsy.
FosphenytoinAn antiepileptic agent used for the management of generalized convulsive status epilepticus and prevention and treatment of seizures occurring during neurosurgery.
PhenytoinAn anticonvulsant drug used in the prophylaxis and control of various types of seizures.
CarbamazepineAn anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia.
HeparinAn anticoagulant indicated for thromboprophylaxis and to treat thrombosis associated with a variety of conditions such as pulmonary embolism and atrial fibrillation.
NitrofurantoinAn antibiotic used to treat urinary tract infections.
AllantoinAn ingredient used in skin care products to relieve irritation and protect minor cuts, scrapes, and burns.
DantroleneA direct-acting skeletal muscle relaxant used for the treatment of management of the fulminant hypermetabolism of skeletal muscle leading to malignant hyperthermia crisis.
EnzalutamideAn androgen receptor inhibitor used to treat castration-resistant prostate cancer.
EthotoinA hydantoin antiepileptic used to control tonic-clonic and complex partial seizures.
NeocitrullamonNot Annotated
EtofenamateEtofenamate is used to treat muscle and joint paint. It is a non-steroidal anti-inflammatory drug (NSAID).
Meclofenamic acidAn NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis.
Drugs & Drug Targets
DrugTargetType
LiothyronineThyroid hormone receptor betatarget
LiothyronineThyroid hormone receptor alphatarget
LiothyronineThyroxine-binding globulincarrier
LiothyronineTransthyretincarrier
LiothyronineSerum albumincarrier
LiothyronineP-glycoprotein 1transporter
LiothyronineSolute carrier family 22 member 8transporter
LiothyronineMonocarboxylate transporter 10transporter
LiothyronineSolute carrier organic anion transporter family member 4A1transporter
LiothyronineSolute carrier organic anion transporter family member 1C1transporter
LiothyronineSolute carrier organic anion transporter family member 1A2transporter
LiothyronineSodium/bile acid cotransportertransporter
LiothyronineSolute carrier organic anion transporter family member 4C1transporter
LiothyronineSolute carrier organic anion transporter family member 1B3transporter
LiothyronineSolute carrier organic anion transporter family member 1B1transporter
LiothyronineLarge neutral amino acids transporter small subunit 1transporter
LiothyronineProliferating cell nuclear antigentarget
LiothyronineUDP-glucuronosyltransferase 1-1enzyme
Liothyronine I-131Thyroxine-binding globulincarrier
LiotrixThyroid hormone receptor alphatarget
LiotrixThyroid hormone receptor betatarget
LiotrixCytochrome P450 2C8enzyme
LiotrixSolute carrier organic anion transporter family member 1A2transporter
LiotrixSolute carrier organic anion transporter family member 1B1transporter
LiotrixSolute carrier organic anion transporter family member 1B3transporter
LiotrixSolute carrier organic anion transporter family member 4C1transporter
LiotrixSodium/bile acid cotransportertransporter
LiotrixSolute carrier organic anion transporter family member 1C1transporter
LiotrixSolute carrier organic anion transporter family member 4A1transporter
LiotrixSolute carrier family 22 member 8transporter
LiotrixMonocarboxylate transporter 8transporter
LiotrixMonocarboxylate transporter 10transporter
LiotrixP-glycoprotein 1transporter
LiotrixTransthyretincarrier
LiotrixThyroxine-binding globulincarrier
LiotrixSerum albumincarrier
LiotrixCytochrome P450 3A4enzyme
LevothyroxineThyroid hormone receptor alphatarget
LevothyroxineThyroid hormone receptor betatarget
LevothyroxineCytochrome P450 2C8enzyme
LevothyroxineTransthyretincarrier
LevothyroxineSerum albumincarrier
LevothyroxineThyroxine-binding globulincarrier
LevothyroxineP-glycoprotein 1transporter
LevothyroxineMonocarboxylate transporter 8transporter
LevothyroxineSolute carrier organic anion transporter family member 1C1transporter
LevothyroxineSolute carrier organic anion transporter family member 1A2transporter
LevothyroxineSolute carrier organic anion transporter family member 1B1transporter
LevothyroxineSolute carrier organic anion transporter family member 1B3transporter
LevothyroxineSolute carrier organic anion transporter family member 4A1transporter
LevothyroxineLarge neutral amino acids transporter small subunit 1transporter
LevothyroxineUDP-glucuronosyltransferase 1-1enzyme
LevothyroxineSolute carrier organic anion transporter family member 2B1transporter
LevothyroxineIntegrin alpha-Vtarget
LevothyroxineIntegrin beta-3target
LevothyroxineP-glycoprotein 1enzyme
FurosemideSolute carrier family 12 member 1target
FurosemideSerum albumincarrier
FurosemideSolute carrier family 22 member 6transporter
FurosemideSolute carrier family 22 member 5transporter
FurosemideSolute carrier family 22 member 8transporter
FurosemideCanalicular multispecific organic anion transporter 1transporter
FurosemideSolute carrier organic anion transporter family member 2A1transporter
FurosemideSolute carrier family 22 member 11transporter
Furosemide6-phosphogluconate dehydrogenase, decarboxylatingenzyme
FurosemideCarbonic anhydrase 2target
FurosemideUDP-glucuronosyltransferase 1-1enzyme
FurosemideThyroxine-binding globulincarrier
FurosemideG-protein coupled receptor 35target
MephenytoinSodium channel protein type 5 subunit alphatarget
MephenytoinCytochrome P450 2B6enzyme
MephenytoinCytochrome P450 2C9enzyme
MephenytoinCytochrome P450 2C19enzyme
MephenytoinCytochrome P450 1A2enzyme
MephenytoinCytochrome P450 2D6enzyme
MephenytoinCytochrome P450 2C8enzyme
MephenytoinNuclear receptor subfamily 1 group I member 2target
MephenytoinThyroxine-binding globulincarrier
FosphenytoinSodium channel protein type 5 subunit alphatarget
FosphenytoinCytochrome P450 2C19enzyme
FosphenytoinCytochrome P450 2B6enzyme
FosphenytoinCytochrome P450 2C9enzyme
FosphenytoinCytochrome P450 3A4enzyme
FosphenytoinSerum albumincarrier
FosphenytoinCytochrome P450 1A2enzyme
FosphenytoinUDP-glucuronosyltransferase 1-6enzyme
FosphenytoinUDP-glucuronosyltransferase 1-9enzyme
FosphenytoinThyroxine-binding globulincarrier
PhenytoinSodium channel protein type 5 subunit alphatarget
PhenytoinSodium channel protein type 1 subunit alphatarget
PhenytoinCytochrome P450 2C8enzyme
PhenytoinCytochrome P450 2C19enzyme
PhenytoinCytochrome P450 2C9enzyme
PhenytoinCytochrome P450 2B6enzyme
PhenytoinCytochrome P450 3A5enzyme
PhenytoinSerum albumincarrier
PhenytoinCytochrome P450 3A4enzyme
PhenytoinSolute carrier organic anion transporter family member 1C1transporter
PhenytoinP-glycoprotein 1transporter
PhenytoinCanalicular multispecific organic anion transporter 1transporter
PhenytoinCytochrome P450 11B1, mitochondrialenzyme
PhenytoinCytochrome P450 3A7enzyme
PhenytoinNuclear receptor subfamily 1 group I member 2target
PhenytoinSodium channel subunit beta-1target
PhenytoinSodium channel protein type 3 subunit alphatarget
PhenytoinUDP-glucuronosyltransferase 1-1enzyme
PhenytoinUDP-glucuronosyltransferase 1-6enzyme
PhenytoinUDP-glucuronosyltransferase 1-9enzyme
PhenytoinThyroxine-binding globulincarrier
PhenytoinPotassium voltage-gated channel subfamily H member 2target
PhenytoinVoltage-dependent L-type calcium channeltarget
PhenytoinSodium channel protein type 2 subunit alphatarget
PhenytoinSodium channel protein type 8 subunit alphatarget
PhenytoinGABA(A) Receptortarget
PhenytoinCytochrome P450 1A2enzyme
PhenytoinCytochrome P450 2A6enzyme
PhenytoinCytochrome P450 2D6enzyme
PhenytoinCytochrome P450 2E1enzyme
PhenytoinEpoxide hydrolase 1enzyme
PhenytoinUDP-glucuronosyltransferase 1-4enzyme
PhenytoinCatechol O-methyltransferaseenzyme
PhenytoinNAD(P)H dehydrogenase [quinone] 1enzyme
PhenytoinCytochrome P450 2C18enzyme
CarbamazepineVoltage-gated sodium channel alpha subunittarget
CarbamazepineCytochrome P450 2C8enzyme
CarbamazepineCytochrome P450 2B6enzyme
CarbamazepineCytochrome P450 3A4enzyme
CarbamazepineCytochrome P450 1A2enzyme
CarbamazepineCytochrome P450 2C19enzyme
CarbamazepineCytochrome P450 2C9enzyme
CarbamazepineP-glycoprotein 1transporter
CarbamazepineCytochrome P450 3A5enzyme
CarbamazepineUDP-glucuronosyltransferase 2B7enzyme
CarbamazepineRalA-binding protein 1transporter
CarbamazepineCanalicular multispecific organic anion transporter 1transporter
CarbamazepineNeuronal acetylcholine receptor subunit alpha-4target
CarbamazepineNuclear receptor subfamily 1 group I member 2target
CarbamazepineUDP-glucuronosyltransferase 1-1enzyme
CarbamazepineUDP-glucuronosyltransferase 1-6enzyme
CarbamazepineUDP-glucuronosyltransferase 1-7enzyme
HeparinAntithrombin-IIItarget
HeparinCoagulation factor Xtarget
HeparinP-selectintarget
HeparinHeparanaseenzyme
HeparinFibroblast growth factor receptor 4target
HeparinFibroblast growth factor 4target
HeparinFibroblast growth factor 19target
HeparinFibroblast growth factor receptor 1target
HeparinFibroblast growth factor 1target
HeparinFibroblast growth factor receptor 2target
HeparinFibroblast growth factor 2target
HeparinPlatelet factor 4target
HeparinHepatocyte growth factortarget
HeparinThyroxine-binding globulincarrier
Nitrofurantoin30S ribosomal protein S10target
NitrofurantoinOxygen-insensitive NADPH nitroreductasetarget
NitrofurantoinProbable pyruvate-flavodoxin oxidoreductasetarget
NitrofurantoinATP-binding cassette sub-family G member 2transporter
NitrofurantoinNADPH--cytochrome P450 reductaseenzyme
NitrofurantoinBile salt export pumptransporter
NitrofurantoinP-glycoprotein 1transporter
NitrofurantoinCanalicular multispecific organic anion transporter 1transporter
AllantoinThyroxine-binding globulincarrier
DantroleneRyanodine receptor 1target
DantroleneThyroxine-binding globulincarrier
EnzalutamideSerum albumincarrier
EnzalutamideCytochrome P450 2C8enzyme
EnzalutamideCytochrome P450 3A4enzyme
EnzalutamideAndrogen receptortarget
EnzalutamideCytochrome P450 2C9enzyme
EnzalutamideCytochrome P450 2C19enzyme
EnzalutamideCytochrome P450 2B6enzyme
EnzalutamideCytochrome P450 3A5enzyme
EnzalutamideP-glycoprotein 1transporter
EnzalutamideThyroxine-binding globulincarrier
EthotoinSodium channel protein type 5 subunit alphatarget
EthotoinNuclear receptor subfamily 1 group I member 2target
EthotoinThyroxine-binding globulincarrier
NeocitrullamonThyroxine-binding globulincarrier
EtofenamateThyroxine-binding globulincarrier
Meclofenamic acidProstaglandin G/H synthase 1target
Meclofenamic acidProstaglandin G/H synthase 2target
Meclofenamic acidArachidonate 5-lipoxygenasetarget
Meclofenamic acidSolute carrier family 22 member 6transporter
Meclofenamic acidSolute carrier organic anion transporter family member 1C1transporter
Meclofenamic acidPotassium voltage-gated channel subfamily KQT member 2target
Meclofenamic acidPotassium voltage-gated channel subfamily KQT member 3target
Meclofenamic acidThyroxine-binding globulincarrier