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Identification
NameEnzalutamide
Accession NumberDB08899
TypeSmall Molecule
GroupsApproved
DescriptionEnzalutamide is an androgen receptor inhibitor for the treatment of castration-resistant prostate cancer. FDA approved on August 31, 2012.
Structure
Thumb
Synonyms
MDV 3100
MDV-3100
MDV3100
XTANDI
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
XtandiCapsule40 mgOralAstellas Pharma Canada Inc2013-06-07Not applicableCanada
XtandiCapsule40 mgOralAstellas Pharma Europe B.V.2013-06-21Not applicableEu
XtandiCapsule40 mg/1OralAstellas Pharma US, Inc.2012-08-31Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNII93T0T9GKNU
CAS number915087-33-1
WeightAverage: 464.436
Monoisotopic: 464.093009286
Chemical FormulaC21H16F4N4O2S
InChI KeyWXCXUHSOUPDCQV-UHFFFAOYSA-N
InChI
InChI=1S/C21H16F4N4O2S/c1-20(2)18(31)28(12-5-4-11(10-26)15(8-12)21(23,24)25)19(32)29(20)13-6-7-14(16(22)9-13)17(30)27-3/h4-9H,1-3H3,(H,27,30)
IUPAC Name
4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl}-2-fluoro-N-methylbenzamide
SMILES
CNC(=O)C1=C(F)C=C(C=C1)N1C(=S)N(C(=O)C1(C)C)C1=CC=C(C#N)C(=C1)C(F)(F)F
Pharmacology
IndicationEnzalutamide is indicated for the treatment of patients with metastatic castration-resistant prostate cancer who have previously received docetaxel.
Structured Indications
PharmacodynamicsResitance to enzalutamide therapy has been observed. This may occurred due to an upregulation of NF-κB2/p52.
Mechanism of actionEnzalutamide is a competitive androgen receptor inhibitor that effects multiple stages of the signalling pathway. It is able to inhibit androgen binding to its receptor, androgen receptor nuclear translocation, and subsequent interaction with DNA. As a result, proliferation of prostate cancer cells decreases which ultimately leads to apoptosis and decreased tumour volume.
TargetKindPharmacological actionActionsOrganismUniProt ID
Androgen receptorProteinyes
inhibitor
HumanP10275 details
Related Articles
AbsorptionThe pharmacokinetic profile of enzalutamide and N-desmethyl enzalutamide (its major active metabolite) is described by a linear two-compartment model with first-order absorption. Enzalutamide also accumulates. Food does not affect its absorption. Tmax, prostate cancer patients = 1 hour (range of 0.5-3 hours); Cmax, steady state, enzalutamide = 16.6 μg/mL; Cmax, steady state, N-desmethyl enzalutamide = 12.7 μg/mL; Time to steady state, daily dosing = 28 days;
Volume of distribution

Apparent volume of distribution (Vd/F), single oral dose = 110 L

Protein bindingEnzalutamide is 97% to 98% bound to plasma proteins, primarily albumin. N-desmethyl enzalutamide is 95% bound to plasma proteins.
Metabolism

Enzalutamide is hepatically metabolized, primarily by CYP2C8 and CYP3A4. The enzyme that converts enzalutamide to its active metabolite, N-desmethyl enzalutamide, is CYP2C8. The activity of N-desmethyl-enzalutamide is similar to that of the parent compound.

Route of eliminationEnzalutamide is primarily eliminated by hepatic metabolism. 71% of the dose is recovered in urine (including only trace amounts of enzalutamide and N-desmethyl enzalutamide), and 14% is recovered in feces (0.4% of dose as unchanged enzalutamide and 1% as N-desmethyl enzalutamide).
Half lifeThe mean terminal half-life (t1/2) for enzalutamide in patients after a single oral dose is 5.8 days (range 2.8 to 10.2 days). Following a single 160 mg oral dose of enzalutamide in healthy volunteers, the mean terminal t1/2 for N-desmethyl enzalutamide is approximately 7.8 to 8.6 days.
Clearance

Apparent clearance (CL/F), single oral dose = 0.56 L/h (range of 0.33 – 1.02 L/h)

ToxicityThe most common adverse reactions (≥ 5%) are asthenia/fatigue, back pain, diarrhea, arthralgia, hot flush, peripheral edema, musculoskeletal pain, headache, upper respiratory infection, muscular weakness, dizziness, insomnia, lower respiratory infection, spinal cord compression and cauda equina syndrome, hematuria, paresthesia, anxiety, and hypertension.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be decreased when it is combined with Enzalutamide.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be decreased when it is combined with Enzalutamide.Experimental, Illicit
4-AndrostenedioneThe serum concentration of 4-Androstenedione can be decreased when it is combined with Enzalutamide.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be decreased when it is combined with Enzalutamide.Experimental, Illicit
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Enzalutamide.Approved
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Enzalutamide.Approved
AcenocoumarolThe serum concentration of Acenocoumarol can be decreased when it is combined with Enzalutamide.Approved
AcetaminophenThe serum concentration of Acetaminophen can be decreased when it is combined with Enzalutamide.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Enzalutamide.Approved, Vet Approved
AdinazolamThe serum concentration of Adinazolam can be decreased when it is combined with Enzalutamide.Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Enzalutamide.Approved
AlbendazoleThe serum concentration of Albendazole can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
AlclometasoneThe serum concentration of Alclometasone can be decreased when it is combined with Enzalutamide.Approved
AldosteroneThe serum concentration of Aldosterone can be increased when it is combined with Enzalutamide.Experimental
AlfentanilThe serum concentration of Alfentanil can be decreased when it is combined with Enzalutamide.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be decreased when it is combined with Enzalutamide.Approved, Investigational
AliskirenThe serum concentration of Aliskiren can be decreased when it is combined with Enzalutamide.Approved, Investigational
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Enzalutamide.Approved, Investigational
AllylestrenolThe serum concentration of Allylestrenol can be decreased when it is combined with Enzalutamide.Approved
AlmotriptanThe serum concentration of Almotriptan can be decreased when it is combined with Enzalutamide.Approved, Investigational
AlogliptinThe serum concentration of Alogliptin can be decreased when it is combined with Enzalutamide.Approved
AlosetronThe serum concentration of Alosetron can be decreased when it is combined with Enzalutamide.Approved, Withdrawn
AlprazolamThe serum concentration of Alprazolam can be decreased when it is combined with Enzalutamide.Approved, Illicit, Investigational
AmbrisentanThe serum concentration of Ambrisentan can be decreased when it is combined with Enzalutamide.Approved, Investigational
AmbroxolThe serum concentration of Ambroxol can be decreased when it is combined with Enzalutamide.Approved
AmcinonideThe serum concentration of Amcinonide can be decreased when it is combined with Enzalutamide.Approved
AminophenazoneThe serum concentration of Aminophenazone can be decreased when it is combined with Enzalutamide.Approved, Withdrawn
AminophyllineThe serum concentration of Aminophylline can be decreased when it is combined with Enzalutamide.Approved
AmiodaroneThe serum concentration of Amiodarone can be decreased when it is combined with Enzalutamide.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be decreased when it is combined with Enzalutamide.Approved
AmlodipineThe serum concentration of Amlodipine can be decreased when it is combined with Enzalutamide.Approved
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Enzalutamide.Approved
AmprenavirThe serum concentration of Amprenavir can be decreased when it is combined with Enzalutamide.Approved
AnecortaveThe serum concentration of Anecortave can be decreased when it is combined with Enzalutamide.Investigational
AntipyrineThe serum concentration of Antipyrine can be decreased when it is combined with Enzalutamide.Approved
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Enzalutamide.Approved
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Enzalutamide.Approved, Investigational
AprepitantThe serum concentration of Aprepitant can be decreased when it is combined with Enzalutamide.Approved, Investigational
ArgatrobanThe serum concentration of Argatroban can be decreased when it is combined with Enzalutamide.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Enzalutamide.Approved, Investigational
Arsenic trioxideThe serum concentration of Arsenic trioxide can be increased when it is combined with Enzalutamide.Approved, Investigational
ArtemetherThe serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Enzalutamide resulting in a loss in efficacy.Approved
AsenapineThe serum concentration of Asenapine can be decreased when it is combined with Enzalutamide.Approved
AstemizoleThe serum concentration of Astemizole can be decreased when it is combined with Enzalutamide.Approved, Withdrawn
AtazanavirThe serum concentration of Atazanavir can be decreased when it is combined with Enzalutamide.Approved, Investigational
AtenololThe serum concentration of Atenolol can be increased when it is combined with Enzalutamide.Approved
AtomoxetineThe metabolism of Enzalutamide can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe serum concentration of Atorvastatin can be decreased when it is combined with Enzalutamide.Approved
AvanafilThe serum concentration of Avanafil can be decreased when it is combined with Enzalutamide.Approved
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Enzalutamide.Approved, Investigational
AzelastineThe serum concentration of Azelastine can be decreased when it is combined with Enzalutamide.Approved
AzithromycinThe serum concentration of Azithromycin can be decreased when it is combined with Enzalutamide.Approved
BanoxantroneThe serum concentration of Banoxantrone can be decreased when it is combined with Enzalutamide.Investigational
BeclomethasoneThe serum concentration of Beclomethasone can be decreased when it is combined with Enzalutamide.Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be decreased when it is combined with Enzalutamide.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Enzalutamide.Approved
BenzphetamineThe serum concentration of Benzphetamine can be decreased when it is combined with Enzalutamide.Approved, Illicit
Benzyl alcoholThe serum concentration of Benzyl alcohol can be decreased when it is combined with Enzalutamide.Approved
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Enzalutamide.Approved, Vet Approved
BexaroteneThe serum concentration of Enzalutamide can be decreased when it is combined with Bexarotene.Approved, Investigational
BezafibrateThe serum concentration of Bezafibrate can be decreased when it is combined with Enzalutamide.Approved
BicalutamideThe serum concentration of Bicalutamide can be decreased when it is combined with Enzalutamide.Approved
BisoprololThe serum concentration of Bisoprolol can be decreased when it is combined with Enzalutamide.Approved
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Enzalutamide.Approved
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Enzalutamide.Approved, Investigational
BosentanThe serum concentration of Enzalutamide can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Enzalutamide.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Enzalutamide.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Enzalutamide.Approved
BrinzolamideThe serum concentration of Brinzolamide can be decreased when it is combined with Enzalutamide.Approved
BromazepamThe serum concentration of Bromazepam can be decreased when it is combined with Enzalutamide.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be decreased when it is combined with Enzalutamide.Approved, Investigational
BrompheniramineThe serum concentration of Brompheniramine can be decreased when it is combined with Enzalutamide.Approved
BudesonideThe serum concentration of Budesonide can be decreased when it is combined with Enzalutamide.Approved
BupivacaineThe serum concentration of Bupivacaine can be decreased when it is combined with Enzalutamide.Approved, Investigational
BuprenorphineThe serum concentration of Buprenorphine can be decreased when it is combined with Enzalutamide.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be decreased when it is combined with Enzalutamide.Approved
BuspironeThe serum concentration of Buspirone can be decreased when it is combined with Enzalutamide.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be decreased when it is combined with Enzalutamide.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be decreased when it is combined with Enzalutamide.Approved
CabergolineThe serum concentration of Cabergoline can be decreased when it is combined with Enzalutamide.Approved
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Enzalutamide.Approved
CaffeineThe serum concentration of Caffeine can be decreased when it is combined with Enzalutamide.Approved
CalcitriolThe serum concentration of Calcitriol can be decreased when it is combined with Enzalutamide.Approved, Nutraceutical
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Enzalutamide.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be decreased when it is combined with Enzalutamide.Approved
CannabidiolThe serum concentration of Cannabidiol can be decreased when it is combined with Enzalutamide.Approved, Investigational
CarbamazepineThe serum concentration of Enzalutamide can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe serum concentration of Carbinoxamine can be decreased when it is combined with Enzalutamide.Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Enzalutamide.Approved
CariprazineThe serum concentration of Cariprazine can be decreased when it is combined with Enzalutamide.Approved
CarvedilolThe serum concentration of Carvedilol can be decreased when it is combined with Enzalutamide.Approved, Investigational
CelecoxibThe serum concentration of Celecoxib can be decreased when it is combined with Enzalutamide.Approved, Investigational
CeliprololThe serum concentration of Celiprolol can be decreased when it is combined with Enzalutamide.Approved, Investigational
CephalexinThe serum concentration of Cephalexin can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be decreased when it is combined with Enzalutamide.Approved
CerivastatinThe serum concentration of Cerivastatin can be decreased when it is combined with Enzalutamide.Withdrawn
CevimelineThe serum concentration of Cevimeline can be decreased when it is combined with Enzalutamide.Approved
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be decreased when it is combined with Enzalutamide.Approved
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be decreased when it is combined with Enzalutamide.Approved, Illicit
ChloroquineThe serum concentration of Chloroquine can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
ChlorphenamineThe serum concentration of Chlorphenamine can be decreased when it is combined with Enzalutamide.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be decreased when it is combined with Enzalutamide.Approved
CholecalciferolThe serum concentration of Cholecalciferol can be decreased when it is combined with Enzalutamide.Approved, Nutraceutical
CiclesonideThe serum concentration of Ciclesonide can be decreased when it is combined with Enzalutamide.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be decreased when it is combined with Enzalutamide.Approved
CimetidineThe serum concentration of Cimetidine can be increased when it is combined with Enzalutamide.Approved
CinacalcetThe serum concentration of Cinacalcet can be decreased when it is combined with Enzalutamide.Approved
CiprofloxacinThe serum concentration of Ciprofloxacin can be increased when it is combined with Enzalutamide.Approved, Investigational
CisaprideThe serum concentration of Cisapride can be decreased when it is combined with Enzalutamide.Approved, Investigational, Withdrawn
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Enzalutamide.Approved
CitalopramThe serum concentration of Citalopram can be decreased when it is combined with Enzalutamide.Approved
ClarithromycinThe serum concentration of Clarithromycin can be decreased when it is combined with Enzalutamide.Approved
ClemastineThe metabolism of Enzalutamide can be decreased when combined with Clemastine.Approved
ClindamycinThe serum concentration of Clindamycin can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
ClobazamThe serum concentration of Clobazam can be decreased when it is combined with Enzalutamide.Approved, Illicit
ClobetasolThe serum concentration of Clobetasol can be decreased when it is combined with Enzalutamide.Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be decreased when it is combined with Enzalutamide.Approved
ClocortoloneThe serum concentration of Clocortolone can be decreased when it is combined with Enzalutamide.Approved
ClofazimineThe serum concentration of Clofazimine can be decreased when it is combined with Enzalutamide.Approved, Investigational
ClofibrateThe serum concentration of Clofibrate can be decreased when it is combined with Enzalutamide.Approved
clomethiazoleThe serum concentration of clomethiazole can be decreased when it is combined with Enzalutamide.Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Enzalutamide.Approved, Investigational
ClomipramineThe serum concentration of Clomipramine can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
ClonazepamThe serum concentration of Clonazepam can be decreased when it is combined with Enzalutamide.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be decreased when it is combined with Enzalutamide.Approved
ClopidogrelThe serum concentration of Enzalutamide can be increased when it is combined with Clopidogrel.Approved, Nutraceutical
ClorazepateThe serum concentration of Clorazepate can be decreased when it is combined with Enzalutamide.Approved, Illicit
ClotiazepamThe serum concentration of Clotiazepam can be decreased when it is combined with Enzalutamide.Approved, Illicit
ClotrimazoleThe metabolism of Enzalutamide can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Enzalutamide.Approved
CobicistatThe serum concentration of Enzalutamide can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Enzalutamide.Approved
CocaineThe serum concentration of Cocaine can be decreased when it is combined with Enzalutamide.Approved, Illicit
CodeineThe serum concentration of Codeine can be decreased when it is combined with Enzalutamide.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be decreased when it is combined with Enzalutamide.Approved
ConivaptanThe serum concentration of Enzalutamide can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be decreased when it is combined with Enzalutamide.Approved
Cortisone acetateThe serum concentration of Cortisone acetate can be decreased when it is combined with Enzalutamide.Approved
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Enzalutamide.Approved
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be decreased when it is combined with Enzalutamide.Approved
CyclophosphamideThe serum concentration of Cyclophosphamide can be decreased when it is combined with Enzalutamide.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be decreased when it is combined with Enzalutamide.Approved, Investigational, Vet Approved
CytarabineThe serum concentration of Cytarabine can be decreased when it is combined with Enzalutamide.Approved, Investigational
Dabigatran etexilateThe serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Enzalutamide.Approved
DabrafenibThe serum concentration of Enzalutamide can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Enzalutamide.Approved
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Enzalutamide.Approved
DantroleneThe serum concentration of Dantrolene can be decreased when it is combined with Enzalutamide.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be decreased when it is combined with Enzalutamide.Approved
DapsoneThe serum concentration of Dapsone can be decreased when it is combined with Enzalutamide.Approved, Investigational
DarifenacinThe serum concentration of Darifenacin can be decreased when it is combined with Enzalutamide.Approved, Investigational
DarunavirThe serum concentration of Darunavir can be decreased when it is combined with Enzalutamide.Approved
DasabuvirThe serum concentration of Dasabuvir can be decreased when it is combined with Enzalutamide.Approved
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Enzalutamide.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be decreased when it is combined with Enzalutamide.Approved
DebrisoquinThe serum concentration of Debrisoquin can be increased when it is combined with Enzalutamide.Approved
DeferasiroxThe serum concentration of Enzalutamide can be decreased when it is combined with Deferasirox.Approved, Investigational
dehydroepiandrosterone sulfateThe serum concentration of dehydroepiandrosterone sulfate can be decreased when it is combined with Enzalutamide.Investigational
DelavirdineThe serum concentration of Delavirdine can be decreased when it is combined with Enzalutamide.Approved
DesoximetasoneThe serum concentration of Desoximetasone can be decreased when it is combined with Enzalutamide.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be decreased when it is combined with Enzalutamide.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be decreased when it is combined with Enzalutamide.Experimental, Vet Approved
DesvenlafaxineThe serum concentration of Desvenlafaxine can be decreased when it is combined with Enzalutamide.Approved
DexamethasoneThe serum concentration of Enzalutamide can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be decreased when it is combined with Enzalutamide.Vet Approved
DextromethorphanThe serum concentration of Dextromethorphan can be decreased when it is combined with Enzalutamide.Approved
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be decreased when it is combined with Enzalutamide.Approved, Illicit, Withdrawn
DiazepamThe serum concentration of Diazepam can be decreased when it is combined with Enzalutamide.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
DienogestThe serum concentration of Dienogest can be decreased when it is combined with Enzalutamide.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Enzalutamide.Approved
DiflorasoneThe serum concentration of Diflorasone can be decreased when it is combined with Enzalutamide.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be decreased when it is combined with Enzalutamide.Approved
DifluprednateThe serum concentration of Difluprednate can be decreased when it is combined with Enzalutamide.Approved
DigitoxinThe serum concentration of Digitoxin can be decreased when it is combined with Enzalutamide.Approved
DigoxinThe serum concentration of Digoxin can be decreased when it is combined with Enzalutamide.Approved
DihydrocodeineThe serum concentration of Dihydrocodeine can be decreased when it is combined with Enzalutamide.Approved, Illicit
DihydroergotamineThe serum concentration of Dihydroergotamine can be decreased when it is combined with Enzalutamide.Approved
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Enzalutamide.Illicit
DiltiazemThe serum concentration of Diltiazem can be decreased when it is combined with Enzalutamide.Approved
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Enzalutamide.Approved
DisopyramideThe serum concentration of Disopyramide can be decreased when it is combined with Enzalutamide.Approved
DisulfiramThe serum concentration of Disulfiram can be decreased when it is combined with Enzalutamide.Approved
DocetaxelThe serum concentration of Docetaxel can be decreased when it is combined with Enzalutamide.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be decreased when it is combined with Enzalutamide.Approved
DolasetronThe serum concentration of Dolasetron can be decreased when it is combined with Enzalutamide.Approved
DomperidoneThe serum concentration of Domperidone can be decreased when it is combined with Enzalutamide.Approved, Investigational, Vet Approved
DonepezilThe serum concentration of Donepezil can be decreased when it is combined with Enzalutamide.Approved
DorzolamideThe serum concentration of Dorzolamide can be decreased when it is combined with Enzalutamide.Approved
DoxepinThe serum concentration of Doxepin can be decreased when it is combined with Enzalutamide.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Enzalutamide.Approved, Investigational
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Enzalutamide.Approved, Investigational
DoxycyclineThe metabolism of Enzalutamide can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be decreased when it is combined with Enzalutamide.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Enzalutamide.Approved
DutasterideThe serum concentration of Dutasteride can be decreased when it is combined with Enzalutamide.Approved, Investigational
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Enzalutamide.Approved
EfavirenzThe serum concentration of Enzalutamide can be decreased when it is combined with Efavirenz.Approved, Investigational
EletriptanThe serum concentration of Eletriptan can be decreased when it is combined with Enzalutamide.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Enzalutamide.Approved
ElvitegravirThe serum concentration of Elvitegravir can be decreased when it is combined with Enzalutamide.Approved
EnalaprilThe serum concentration of Enalapril can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
EpinastineThe serum concentration of Epinastine can be decreased when it is combined with Enzalutamide.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be decreased when it is combined with Enzalutamide.Approved
EquileninThe serum concentration of Equilenin can be decreased when it is combined with Enzalutamide.Experimental
EquilinThe serum concentration of Equilin can be decreased when it is combined with Enzalutamide.Approved
ErgocalciferolThe serum concentration of Ergocalciferol can be decreased when it is combined with Enzalutamide.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be decreased when it is combined with Enzalutamide.Approved
ErgonovineThe serum concentration of Ergonovine can be decreased when it is combined with Enzalutamide.Approved
ErgotamineThe serum concentration of Ergotamine can be decreased when it is combined with Enzalutamide.Approved
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Enzalutamide.Approved, Investigational
ErythromycinThe serum concentration of Erythromycin can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
EscitalopramThe serum concentration of Escitalopram can be decreased when it is combined with Enzalutamide.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Enzalutamide can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsomeprazoleThe serum concentration of Esomeprazole can be decreased when it is combined with Enzalutamide.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be decreased when it is combined with Enzalutamide.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be decreased when it is combined with Enzalutamide.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be decreased when it is combined with Enzalutamide.Approved
EstramustineThe serum concentration of Estramustine can be decreased when it is combined with Enzalutamide.Approved
EstriolThe serum concentration of Estriol can be increased when it is combined with Enzalutamide.Approved, Vet Approved
EstroneThe serum concentration of Estrone can be decreased when it is combined with Enzalutamide.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be decreased when it is combined with Enzalutamide.Approved
EszopicloneThe serum concentration of Eszopiclone can be decreased when it is combined with Enzalutamide.Approved
EthanolThe serum concentration of Ethanol can be decreased when it is combined with Enzalutamide.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be decreased when it is combined with Enzalutamide.Approved
EthosuximideThe serum concentration of Ethosuximide can be decreased when it is combined with Enzalutamide.Approved
EthylmorphineThe serum concentration of Ethylmorphine can be decreased when it is combined with Enzalutamide.Approved, Illicit
EtonogestrelThe serum concentration of Etonogestrel can be decreased when it is combined with Enzalutamide.Approved, Investigational
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Enzalutamide.Approved
EtoricoxibThe serum concentration of Etoricoxib can be decreased when it is combined with Enzalutamide.Approved, Investigational
EtravirineThe serum concentration of Enzalutamide can be decreased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Enzalutamide.Approved
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Enzalutamide.Approved, Investigational
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Enzalutamide.Approved
FamciclovirThe serum concentration of Famciclovir can be decreased when it is combined with Enzalutamide.Approved
FelbamateThe serum concentration of Felbamate can be decreased when it is combined with Enzalutamide.Approved
FelodipineThe serum concentration of Felodipine can be decreased when it is combined with Enzalutamide.Approved, Investigational
FenofibrateThe serum concentration of Fenofibrate can be decreased when it is combined with Enzalutamide.Approved
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Enzalutamide.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of Fesoterodine can be decreased when it is combined with Enzalutamide.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Enzalutamide.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Enzalutamide.Approved
FinasterideThe serum concentration of Finasteride can be decreased when it is combined with Enzalutamide.Approved
FingolimodThe serum concentration of Fingolimod can be decreased when it is combined with Enzalutamide.Approved, Investigational
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with Enzalutamide.Approved
fluasteroneThe serum concentration of fluasterone can be decreased when it is combined with Enzalutamide.Investigational
FluconazoleThe metabolism of Enzalutamide can be decreased when combined with Fluconazole.Approved
FludrocortisoneThe serum concentration of Fludrocortisone can be decreased when it is combined with Enzalutamide.Approved
FlumethasoneThe serum concentration of Flumethasone can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
FlunisolideThe serum concentration of Flunisolide can be decreased when it is combined with Enzalutamide.Approved, Investigational
FlunitrazepamThe serum concentration of Flunitrazepam can be decreased when it is combined with Enzalutamide.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be decreased when it is combined with Enzalutamide.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be decreased when it is combined with Enzalutamide.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be decreased when it is combined with Enzalutamide.Approved, Withdrawn
FluorometholoneThe serum concentration of Fluorometholone can be decreased when it is combined with Enzalutamide.Approved
FluoxetineThe serum concentration of Fluoxetine can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
FluprednideneThe serum concentration of Fluprednidene can be decreased when it is combined with Enzalutamide.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be decreased when it is combined with Enzalutamide.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be decreased when it is combined with Enzalutamide.Approved
FlurazepamThe serum concentration of Flurazepam can be decreased when it is combined with Enzalutamide.Approved, Illicit
FlutamideThe serum concentration of Flutamide can be decreased when it is combined with Enzalutamide.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be decreased when it is combined with Enzalutamide.Approved
Fluticasone PropionateThe serum concentration of Fluticasone Propionate can be decreased when it is combined with Enzalutamide.Approved
FluvastatinThe serum concentration of Fluvastatin can be decreased when it is combined with Enzalutamide.Approved
FluvoxamineThe metabolism of Enzalutamide can be decreased when combined with Fluvoxamine.Approved, Investigational
FormestaneThe serum concentration of Formestane can be decreased when it is combined with Enzalutamide.Approved, Investigational, Withdrawn
FosamprenavirThe serum concentration of Fosamprenavir can be decreased when it is combined with Enzalutamide.Approved
FosaprepitantThe serum concentration of Enzalutamide can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Enzalutamide can be decreased when it is combined with Fosphenytoin.Approved
FulvestrantThe serum concentration of Fulvestrant can be decreased when it is combined with Enzalutamide.Approved, Investigational
Fusidic AcidThe serum concentration of Enzalutamide can be increased when it is combined with Fusidic Acid.Approved
GalantamineThe serum concentration of Galantamine can be decreased when it is combined with Enzalutamide.Approved
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Enzalutamide.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Enzalutamide.Approved
GemfibrozilThe serum concentration of Enzalutamide can be increased when it is combined with Gemfibrozil.Approved
GlipizideThe serum concentration of Glipizide can be decreased when it is combined with Enzalutamide.Approved
GlyburideThe serum concentration of Glyburide can be decreased when it is combined with Enzalutamide.Approved
GranisetronThe serum concentration of Granisetron can be decreased when it is combined with Enzalutamide.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Enzalutamide.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be decreased when it is combined with Enzalutamide.Withdrawn
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Enzalutamide.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be decreased when it is combined with Enzalutamide.Approved
HaloperidolThe serum concentration of Haloperidol can be decreased when it is combined with Enzalutamide.Approved
HalothaneThe serum concentration of Halothane can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be decreased when it is combined with Enzalutamide.Investigational
HexobarbitalThe serum concentration of Hexobarbital can be decreased when it is combined with Enzalutamide.Approved
Histamine PhosphateThe serum concentration of Histamine Phosphate can be decreased when it is combined with Enzalutamide.Approved
HydrocodoneThe serum concentration of Hydrocodone can be decreased when it is combined with Enzalutamide.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
HydromorphoneThe serum concentration of Hydromorphone can be decreased when it is combined with Enzalutamide.Approved, Illicit
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Enzalutamide.Approved
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with Enzalutamide.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Enzalutamide.Approved
IdelalisibThe serum concentration of Enzalutamide can be increased when it is combined with Idelalisib.Approved
IfosfamideThe serum concentration of Ifosfamide can be decreased when it is combined with Enzalutamide.Approved
IloperidoneThe serum concentration of Iloperidone can be decreased when it is combined with Enzalutamide.Approved
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Enzalutamide.Approved
ImipramineThe serum concentration of Imipramine can be decreased when it is combined with Enzalutamide.Approved
ImiquimodThe serum concentration of Imiquimod can be decreased when it is combined with Enzalutamide.Approved, Investigational
IndacaterolThe serum concentration of Indacaterol can be decreased when it is combined with Enzalutamide.Approved
IndapamideThe serum concentration of Indapamide can be decreased when it is combined with Enzalutamide.Approved
IndinavirThe serum concentration of Indinavir can be decreased when it is combined with Enzalutamide.Approved
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Enzalutamide.Approved, Investigational
Ipratropium bromideThe serum concentration of Ipratropium bromide can be decreased when it is combined with Enzalutamide.Approved
IrbesartanThe metabolism of Enzalutamide can be decreased when combined with Irbesartan.Approved, Investigational
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be reduced when Irinotecan is used in combination with Enzalutamide resulting in a loss in efficacy.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Enzalutamide resulting in a loss in efficacy.Approved, Investigational
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be decreased when it is combined with Enzalutamide.Approved
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be decreased when it is combined with Enzalutamide.Approved
IsradipineThe serum concentration of Isradipine can be decreased when it is combined with Enzalutamide.Approved
IstaroximeThe serum concentration of Istaroxime can be decreased when it is combined with Enzalutamide.Investigational
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Enzalutamide.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with Enzalutamide.Approved
IvacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with Enzalutamide.Approved
IvermectinThe serum concentration of Ivermectin can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Enzalutamide.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Enzalutamide.Approved
KetamineThe serum concentration of Ketamine can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be decreased when it is combined with Enzalutamide.Approved
KetobemidoneThe serum concentration of Ketobemidone can be decreased when it is combined with Enzalutamide.Approved
KetoconazoleThe serum concentration of Ketoconazole can be decreased when it is combined with Enzalutamide.Approved, Investigational
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Enzalutamide.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Enzalutamide.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be decreased when it is combined with Enzalutamide.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Enzalutamide.Approved, Investigational
LaquinimodThe serum concentration of Laquinimod can be decreased when it is combined with Enzalutamide.Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Enzalutamide.Approved
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Enzalutamide.Approved
LenvatinibThe serum concentration of Lenvatinib can be decreased when it is combined with Enzalutamide.Approved
LercanidipineThe serum concentration of Lercanidipine can be decreased when it is combined with Enzalutamide.Approved, Investigational
LetrozoleThe serum concentration of Letrozole can be decreased when it is combined with Enzalutamide.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Enzalutamide.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be decreased when it is combined with Enzalutamide.Approved
LevocetirizineThe serum concentration of Levocetirizine can be decreased when it is combined with Enzalutamide.Approved
LevofloxacinThe serum concentration of Levofloxacin can be increased when it is combined with Enzalutamide.Approved, Investigational
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be decreased when it is combined with Enzalutamide.Approved
LevomilnacipranThe serum concentration of Levomilnacipran can be decreased when it is combined with Enzalutamide.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be decreased when it is combined with Enzalutamide.Approved, Investigational
LevothyroxineThe serum concentration of Levothyroxine can be decreased when it is combined with Enzalutamide.Approved
LidocaineThe serum concentration of Lidocaine can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Enzalutamide.Approved
LisurideThe serum concentration of Lisuride can be decreased when it is combined with Enzalutamide.Approved
LomitapideThe serum concentration of Lomitapide can be decreased when it is combined with Enzalutamide.Approved
LoperamideThe serum concentration of Loperamide can be decreased when it is combined with Enzalutamide.Approved
LopinavirThe serum concentration of Enzalutamide can be increased when it is combined with Lopinavir.Approved
LoratadineThe serum concentration of Loratadine can be decreased when it is combined with Enzalutamide.Approved
LorcaserinThe serum concentration of Lorcaserin can be decreased when it is combined with Enzalutamide.Approved
LosartanThe serum concentration of Losartan can be decreased when it is combined with Enzalutamide.Approved
LovastatinThe serum concentration of Lovastatin can be decreased when it is combined with Enzalutamide.Approved, Investigational
LuliconazoleThe serum concentration of Enzalutamide can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Enzalutamide can be decreased when it is combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Enzalutamide.Approved
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Enzalutamide.Approved
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Enzalutamide.Approved
MannitolThe serum concentration of Mannitol can be increased when it is combined with Enzalutamide.Approved, Investigational
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Enzalutamide.Approved, Investigational
ME-609The serum concentration of ME-609 can be decreased when it is combined with Enzalutamide.Investigational
MebendazoleThe serum concentration of Mebendazole can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Enzalutamide.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be decreased when it is combined with Enzalutamide.Approved
MefloquineThe serum concentration of Mefloquine can be decreased when it is combined with Enzalutamide.Approved
MelengestrolThe serum concentration of Melengestrol can be decreased when it is combined with Enzalutamide.Vet Approved
MeloxicamThe serum concentration of Meloxicam can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Enzalutamide.Approved
MethaqualoneThe serum concentration of Methaqualone can be decreased when it is combined with Enzalutamide.Illicit, Withdrawn
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Enzalutamide.Approved
MethoxsalenThe serum concentration of Methoxsalen can be decreased when it is combined with Enzalutamide.Approved
MethoxyfluraneThe serum concentration of Methoxyflurane can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
MethyltestosteroneThe serum concentration of Methyltestosterone can be decreased when it is combined with Enzalutamide.Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Enzalutamide.Approved, Investigational
MetronidazoleThe serum concentration of Metronidazole can be decreased when it is combined with Enzalutamide.Approved
MexiletineThe serum concentration of Mexiletine can be decreased when it is combined with Enzalutamide.Approved
MianserinThe serum concentration of Mianserin can be decreased when it is combined with Enzalutamide.Approved
MibefradilThe serum concentration of Mibefradil can be decreased when it is combined with Enzalutamide.Withdrawn
MiconazoleThe serum concentration of Miconazole can be decreased when it is combined with Enzalutamide.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be decreased when it is combined with Enzalutamide.Approved, Illicit
MifepristoneThe serum concentration of Mifepristone can be decreased when it is combined with Enzalutamide.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be decreased when it is combined with Enzalutamide.Approved
MirtazapineThe serum concentration of Mirtazapine can be decreased when it is combined with Enzalutamide.Approved
MitotaneThe serum concentration of Enzalutamide can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Mitoxantrone can be increased when it is combined with Enzalutamide.Approved, Investigational
ModafinilThe serum concentration of Enzalutamide can be decreased when it is combined with Modafinil.Approved, Investigational
MometasoneThe serum concentration of Mometasone can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
MontelukastThe serum concentration of Montelukast can be decreased when it is combined with Enzalutamide.Approved
MorphineThe serum concentration of Morphine can be decreased when it is combined with Enzalutamide.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be decreased when it is combined with Enzalutamide.Approved, Investigational
NadololThe serum concentration of Nadolol can be increased when it is combined with Enzalutamide.Approved
NafcillinThe serum concentration of Enzalutamide can be decreased when it is combined with Nafcillin.Approved
NaloxegolThe serum concentration of Naloxegol can be decreased when it is combined with Enzalutamide.Approved
NaloxoneThe serum concentration of Naloxone can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
NateglinideThe serum concentration of Nateglinide can be decreased when it is combined with Enzalutamide.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be decreased when it is combined with Enzalutamide.Investigational
NefazodoneThe serum concentration of Nefazodone can be decreased when it is combined with Enzalutamide.Approved, Withdrawn
NelfinavirThe serum concentration of Nelfinavir can be decreased when it is combined with Enzalutamide.Approved
NetupitantThe serum concentration of Netupitant can be decreased when it is combined with Enzalutamide.Approved
NevirapineThe serum concentration of Enzalutamide can be decreased when it is combined with Nevirapine.Approved
NicardipineThe serum concentration of Nicardipine can be decreased when it is combined with Enzalutamide.Approved
NicotineThe serum concentration of Nicotine can be decreased when it is combined with Enzalutamide.Approved
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Enzalutamide.Approved
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Enzalutamide.Approved, Investigational
NilvadipineThe serum concentration of Nilvadipine can be decreased when it is combined with Enzalutamide.Approved
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Enzalutamide.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Enzalutamide.Approved
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Enzalutamide.Approved
NitrazepamThe serum concentration of Nitrazepam can be decreased when it is combined with Enzalutamide.Approved
NitrendipineThe serum concentration of Nitrendipine can be decreased when it is combined with Enzalutamide.Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Enzalutamide.Approved
NorethisteroneThe serum concentration of Norethisterone can be decreased when it is combined with Enzalutamide.Approved
NorgestrelThe serum concentration of Norgestrel can be decreased when it is combined with Enzalutamide.Approved
NortriptylineThe serum concentration of Nortriptyline can be decreased when it is combined with Enzalutamide.Approved
OlanzapineThe serum concentration of Olanzapine can be increased when it is combined with Enzalutamide.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with Enzalutamide.Approved
Oleoyl estroneThe serum concentration of Oleoyl estrone can be decreased when it is combined with Enzalutamide.Investigational
OlopatadineThe serum concentration of Olopatadine can be decreased when it is combined with Enzalutamide.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Enzalutamide.Approved
OmeprazoleThe serum concentration of Omeprazole can be decreased when it is combined with Enzalutamide.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be decreased when it is combined with Enzalutamide.Approved
OrphenadrineThe serum concentration of Orphenadrine can be decreased when it is combined with Enzalutamide.Approved
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with Enzalutamide.Approved
OspemifeneThe serum concentration of Ospemifene can be decreased when it is combined with Enzalutamide.Approved
OxazepamThe serum concentration of Oxazepam can be decreased when it is combined with Enzalutamide.Approved
OxybutyninThe serum concentration of Oxybutynin can be decreased when it is combined with Enzalutamide.Approved, Investigational
OxycodoneThe serum concentration of Oxycodone can be decreased when it is combined with Enzalutamide.Approved, Illicit, Investigational
OxymorphoneThe serum concentration of Oxymorphone can be decreased when it is combined with Enzalutamide.Approved, Investigational, Vet Approved
PaclitaxelThe serum concentration of Paclitaxel can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Enzalutamide.Approved
PalonosetronThe serum concentration of Palonosetron can be decreased when it is combined with Enzalutamide.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Enzalutamide.Approved, Investigational
PantoprazoleThe serum concentration of Pantoprazole can be decreased when it is combined with Enzalutamide.Approved
ParamethadioneThe serum concentration of Paramethadione can be decreased when it is combined with Enzalutamide.Approved
ParamethasoneThe serum concentration of Paramethasone can be decreased when it is combined with Enzalutamide.Approved
ParecoxibThe serum concentration of Parecoxib can be decreased when it is combined with Enzalutamide.Approved
ParicalcitolThe serum concentration of Paricalcitol can be decreased when it is combined with Enzalutamide.Approved, Investigational
ParitaprevirThe serum concentration of Paritaprevir can be decreased when it is combined with Enzalutamide.Approved
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Enzalutamide.Approved
PentamidineThe serum concentration of Pentamidine can be decreased when it is combined with Enzalutamide.Approved
PentobarbitalThe serum concentration of Enzalutamide can be decreased when it is combined with Pentobarbital.Approved, Vet Approved
PerampanelThe serum concentration of Perampanel can be decreased when it is combined with Enzalutamide.Approved
PergolideThe serum concentration of Pergolide can be decreased when it is combined with Enzalutamide.Approved, Vet Approved, Withdrawn
PerhexilineThe serum concentration of Perhexiline can be decreased when it is combined with Enzalutamide.Approved
PermethrinThe serum concentration of Permethrin can be decreased when it is combined with Enzalutamide.Approved, Investigational
PerphenazineThe serum concentration of Perphenazine can be decreased when it is combined with Enzalutamide.Approved
PethidineThe serum concentration of Pethidine can be decreased when it is combined with Enzalutamide.Approved
PhenacetinThe serum concentration of Phenacetin can be decreased when it is combined with Enzalutamide.Withdrawn
PhenobarbitalThe serum concentration of Enzalutamide can be decreased when it is combined with Phenobarbital.Approved
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be decreased when it is combined with Enzalutamide.Approved
PhenprocoumonThe serum concentration of Phenprocoumon can be decreased when it is combined with Enzalutamide.Approved
PhenytoinThe serum concentration of Enzalutamide can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PilocarpineThe serum concentration of Pilocarpine can be decreased when it is combined with Enzalutamide.Approved
PimecrolimusThe serum concentration of Pimecrolimus can be decreased when it is combined with Enzalutamide.Approved, Investigational
PimozideThe serum concentration of Pimozide can be decreased when it is combined with Enzalutamide.Approved
PinacidilThe serum concentration of Pinacidil can be decreased when it is combined with Enzalutamide.Withdrawn
PioglitazoneThe serum concentration of Pioglitazone can be decreased when it is combined with Enzalutamide.Approved, Investigational
PipotiazineThe serum concentration of Pipotiazine can be decreased when it is combined with Enzalutamide.Approved
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Enzalutamide.Approved
PodofiloxThe serum concentration of Podofilox can be decreased when it is combined with Enzalutamide.Approved
PomalidomideThe serum concentration of Pomalidomide can be decreased when it is combined with Enzalutamide.Approved
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Enzalutamide.Approved
PosaconazoleThe serum concentration of Posaconazole can be decreased when it is combined with Enzalutamide.Approved, Investigational, Vet Approved
PrasteroneThe serum concentration of Prasterone can be decreased when it is combined with Enzalutamide.Approved, Nutraceutical
PrasugrelThe serum concentration of Prasugrel can be decreased when it is combined with Enzalutamide.Approved
PravastatinThe serum concentration of Pravastatin can be decreased when it is combined with Enzalutamide.Approved
PrazepamThe serum concentration of Prazepam can be decreased when it is combined with Enzalutamide.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Enzalutamide.Approved
PrednicarbateThe serum concentration of Prednicarbate can be decreased when it is combined with Enzalutamide.Approved
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
PregnenoloneThe serum concentration of Pregnenolone can be decreased when it is combined with Enzalutamide.Experimental
PrimaquineThe serum concentration of Primaquine can be decreased when it is combined with Enzalutamide.Approved
PrimidoneThe serum concentration of Enzalutamide can be decreased when it is combined with Primidone.Approved, Vet Approved
ProchlorperazineThe serum concentration of Prochlorperazine can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
ProguanilThe serum concentration of Proguanil can be decreased when it is combined with Enzalutamide.Approved
PromazineThe serum concentration of Promazine can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Enzalutamide.Approved
PropofolThe serum concentration of Propofol can be decreased when it is combined with Enzalutamide.Approved, Investigational, Vet Approved
PropranololThe serum concentration of Propranolol can be decreased when it is combined with Enzalutamide.Approved, Investigational
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Enzalutamide.Approved
PyrazinamideThe serum concentration of Pyrazinamide can be decreased when it is combined with Enzalutamide.Approved
QuazepamThe serum concentration of Quazepam can be decreased when it is combined with Enzalutamide.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Enzalutamide.Approved
QuinacrineThe serum concentration of Quinacrine can be decreased when it is combined with Enzalutamide.Approved
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Enzalutamide.Approved
QuinineThe serum concentration of Quinine can be decreased when it is combined with Enzalutamide.Approved
RabeprazoleThe serum concentration of Rabeprazole can be decreased when it is combined with Enzalutamide.Approved, Investigational
RaloxifeneThe serum concentration of Raloxifene can be decreased when it is combined with Enzalutamide.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be decreased when it is combined with Enzalutamide.Approved, Investigational
RanitidineThe serum concentration of Ranitidine can be increased when it is combined with Enzalutamide.Approved
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Enzalutamide.Approved, Investigational
ReboxetineThe serum concentration of Reboxetine can be decreased when it is combined with Enzalutamide.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Enzalutamide.Approved
RepaglinideThe serum concentration of Repaglinide can be decreased when it is combined with Enzalutamide.Approved, Investigational
ReserpineThe serum concentration of Reserpine can be increased when it is combined with Enzalutamide.Approved
RetapamulinThe serum concentration of Retapamulin can be decreased when it is combined with Enzalutamide.Approved
RifabutinThe serum concentration of Enzalutamide can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Enzalutamide can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Enzalutamide can be decreased when it is combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Enzalutamide.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Enzalutamide.Approved
RimexoloneThe serum concentration of Rimexolone can be decreased when it is combined with Enzalutamide.Approved
RimonabantThe serum concentration of Rimonabant can be decreased when it is combined with Enzalutamide.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be decreased when it is combined with Enzalutamide.Approved
RisperidoneThe serum concentration of Risperidone can be decreased when it is combined with Enzalutamide.Approved, Investigational
RitonavirThe serum concentration of Enzalutamide can be increased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Enzalutamide.Approved
RofecoxibThe serum concentration of Rofecoxib can be decreased when it is combined with Enzalutamide.Investigational, Withdrawn
RoflumilastThe serum concentration of Roflumilast can be decreased when it is combined with Enzalutamide.Approved
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Enzalutamide.Approved
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Enzalutamide.Approved, Investigational
RopiniroleThe serum concentration of Ropinirole can be decreased when it is combined with Enzalutamide.Approved, Investigational
RopivacaineThe serum concentration of Ropivacaine can be decreased when it is combined with Enzalutamide.Approved
RosiglitazoneThe metabolism of Enzalutamide can be decreased when combined with Rosiglitazone.Approved, Investigational
RosuvastatinThe serum concentration of Rosuvastatin can be decreased when it is combined with Enzalutamide.Approved
RotigotineThe serum concentration of Rotigotine can be decreased when it is combined with Enzalutamide.Approved
RoxithromycinThe serum concentration of Roxithromycin can be decreased when it is combined with Enzalutamide.Approved, Withdrawn
RuxolitinibThe serum concentration of Ruxolitinib can be decreased when it is combined with Enzalutamide.Approved
Salicylic acidThe serum concentration of Salicylic acid can be increased when it is combined with Enzalutamide.Approved, Vet Approved
SalmeterolThe serum concentration of Salmeterol can be decreased when it is combined with Enzalutamide.Approved
SaquinavirThe serum concentration of Saquinavir can be decreased when it is combined with Enzalutamide.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Enzalutamide.Approved
SecobarbitalThe serum concentration of Enzalutamide can be decreased when it is combined with Secobarbital.Approved, Vet Approved
SelegilineThe serum concentration of Selegiline can be decreased when it is combined with Enzalutamide.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be decreased when it is combined with Enzalutamide.Approved
SeratrodastThe serum concentration of Seratrodast can be decreased when it is combined with Enzalutamide.Approved, Investigational
SertindoleThe serum concentration of Sertindole can be decreased when it is combined with Enzalutamide.Approved, Withdrawn
SertralineThe serum concentration of Sertraline can be decreased when it is combined with Enzalutamide.Approved
SevofluraneThe serum concentration of Sevoflurane can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
SibutramineThe serum concentration of Sibutramine can be decreased when it is combined with Enzalutamide.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be decreased when it is combined with Enzalutamide.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Enzalutamide.Approved
SiltuximabThe serum concentration of Enzalutamide can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Enzalutamide.Approved
SimvastatinThe serum concentration of Simvastatin can be decreased when it is combined with Enzalutamide.Approved
SirolimusThe serum concentration of Sirolimus can be decreased when it is combined with Enzalutamide.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be decreased when it is combined with Enzalutamide.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Enzalutamide.Approved
SolifenacinThe serum concentration of Solifenacin can be decreased when it is combined with Enzalutamide.Approved
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Enzalutamide.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Enzalutamide.Approved, Investigational
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Enzalutamide.Approved
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Enzalutamide.Experimental
SpiramycinThe serum concentration of Spiramycin can be decreased when it is combined with Enzalutamide.Approved
St. John's WortThe serum concentration of Enzalutamide can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Enzalutamide can be increased when it is combined with Stiripentol.Approved
SufentanilThe serum concentration of Sufentanil can be decreased when it is combined with Enzalutamide.Approved, Investigational
SulfadiazineThe serum concentration of Sulfadiazine can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be decreased when it is combined with Enzalutamide.Approved
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be decreased when it is combined with Enzalutamide.Approved
SulfisoxazoleThe metabolism of Enzalutamide can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Enzalutamide.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be decreased when it is combined with Enzalutamide.Approved
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be decreased when it is combined with Enzalutamide.Approved
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be decreased when it is combined with Enzalutamide.Approved
TacrolimusThe serum concentration of Tacrolimus can be decreased when it is combined with Enzalutamide.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Enzalutamide.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be decreased when it is combined with Enzalutamide.Approved
TamsulosinThe serum concentration of Tamsulosin can be decreased when it is combined with Enzalutamide.Approved, Investigational
TasimelteonThe serum concentration of Tasimelteon can be decreased when it is combined with Enzalutamide.Approved
TasosartanThe serum concentration of Tasosartan can be decreased when it is combined with Enzalutamide.Approved
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be decreased when it is combined with Enzalutamide.Experimental
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Enzalutamide.Experimental
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Enzalutamide.Approved
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Enzalutamide.Approved
TelithromycinThe serum concentration of Telithromycin can be decreased when it is combined with Enzalutamide.Approved
TemazepamThe serum concentration of Temazepam can be decreased when it is combined with Enzalutamide.Approved
TemsirolimusThe serum concentration of Temsirolimus can be decreased when it is combined with Enzalutamide.Approved
TeniposideThe serum concentration of Teniposide can be decreased when it is combined with Enzalutamide.Approved
TerbinafineThe serum concentration of Terbinafine can be decreased when it is combined with Enzalutamide.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be decreased when it is combined with Enzalutamide.Withdrawn
TeriflunomideThe metabolism of Enzalutamide can be decreased when combined with Teriflunomide.Approved
TesmilifeneThe serum concentration of Tesmilifene can be decreased when it is combined with Enzalutamide.Investigational
TestosteroneThe serum concentration of Testosterone can be decreased when it is combined with Enzalutamide.Approved, Investigational
TetracyclineThe serum concentration of Tetracycline can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
TheophyllineThe serum concentration of Theophylline can be decreased when it is combined with Enzalutamide.Approved
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Enzalutamide.Approved
ThiotepaThe serum concentration of Thiotepa can be decreased when it is combined with Enzalutamide.Approved
TiagabineThe serum concentration of Tiagabine can be decreased when it is combined with Enzalutamide.Approved
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Enzalutamide resulting in a loss in efficacy.Approved
TiclopidineThe serum concentration of Ticlopidine can be decreased when it is combined with Enzalutamide.Approved
TimololThe serum concentration of Timolol can be increased when it is combined with Enzalutamide.Approved
TinidazoleThe serum concentration of Tinidazole can be decreased when it is combined with Enzalutamide.Approved, Investigational
TiotropiumThe serum concentration of Tiotropium can be decreased when it is combined with Enzalutamide.Approved
TipranavirThe serum concentration of Tipranavir can be decreased when it is combined with Enzalutamide.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be decreased when it is combined with Enzalutamide.Approved
TocilizumabThe serum concentration of Enzalutamide can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Enzalutamide.Approved, Investigational
TolterodineThe serum concentration of Tolterodine can be decreased when it is combined with Enzalutamide.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Enzalutamide.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Enzalutamide.Approved, Investigational
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Enzalutamide.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Enzalutamide.Approved, Investigational
TramadolThe serum concentration of Tramadol can be decreased when it is combined with Enzalutamide.Approved, Investigational
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be decreased when it is combined with Enzalutamide.Approved
TrazodoneThe serum concentration of Trazodone can be decreased when it is combined with Enzalutamide.Approved, Investigational
TretinoinThe serum concentration of Tretinoin can be decreased when it is combined with Enzalutamide.Approved, Investigational, Nutraceutical
TriamcinoloneThe serum concentration of Triamcinolone can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be decreased when it is combined with Enzalutamide.Approved
TrimethadioneThe serum concentration of Trimethadione can be decreased when it is combined with Enzalutamide.Approved
TrimethoprimThe serum concentration of Trimethoprim can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
TrimipramineThe serum concentration of Trimipramine can be decreased when it is combined with Enzalutamide.Approved
TroglitazoneThe serum concentration of Troglitazone can be decreased when it is combined with Enzalutamide.Withdrawn
TroleandomycinThe serum concentration of Troleandomycin can be decreased when it is combined with Enzalutamide.Approved
UdenafilThe serum concentration of Udenafil can be decreased when it is combined with Enzalutamide.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Enzalutamide.Approved
UmeclidiniumThe serum concentration of Umeclidinium can be increased when it is combined with Enzalutamide.Approved
ValdecoxibThe serum concentration of Valdecoxib can be decreased when it is combined with Enzalutamide.Investigational, Withdrawn
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Enzalutamide.Approved
VanoxerineThe serum concentration of Vanoxerine can be decreased when it is combined with Enzalutamide.Investigational
VardenafilThe serum concentration of Vardenafil can be decreased when it is combined with Enzalutamide.Approved
VecuroniumThe serum concentration of Vecuronium can be increased when it is combined with Enzalutamide.Approved
VemurafenibThe serum concentration of Vemurafenib can be decreased when it is combined with Enzalutamide.Approved
VenetoclaxThe serum concentration of Venetoclax can be decreased when it is combined with Enzalutamide.Approved
VenlafaxineThe serum concentration of Venlafaxine can be decreased when it is combined with Enzalutamide.Approved
VerapamilThe serum concentration of Verapamil can be decreased when it is combined with Enzalutamide.Approved
VicrivirocThe serum concentration of Vicriviroc can be decreased when it is combined with Enzalutamide.Investigational
VilanterolThe serum concentration of Vilanterol can be decreased when it is combined with Enzalutamide.Approved
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Enzalutamide.Approved
VinblastineThe serum concentration of Vinblastine can be decreased when it is combined with Enzalutamide.Approved
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Enzalutamide.Approved, Investigational
VindesineThe serum concentration of Vindesine can be decreased when it is combined with Enzalutamide.Approved
VinorelbineThe serum concentration of Vinorelbine can be decreased when it is combined with Enzalutamide.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be decreased when it is combined with Enzalutamide.Approved
VorapaxarThe serum concentration of Vorapaxar can be decreased when it is combined with Enzalutamide.Approved
VoriconazoleThe serum concentration of Voriconazole can be decreased when it is combined with Enzalutamide.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Enzalutamide.Approved
WarfarinThe serum concentration of Warfarin can be decreased when it is combined with Enzalutamide.Approved
YohimbineThe serum concentration of Yohimbine can be decreased when it is combined with Enzalutamide.Approved, Vet Approved
ZafirlukastThe serum concentration of Zafirlukast can be decreased when it is combined with Enzalutamide.Approved, Investigational
ZalcitabineThe serum concentration of Zalcitabine can be decreased when it is combined with Enzalutamide.Approved
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Enzalutamide.Approved, Illicit, Investigational
ZidovudineThe serum concentration of Zidovudine can be decreased when it is combined with Enzalutamide.Approved
ZileutonThe serum concentration of Zileuton can be decreased when it is combined with Enzalutamide.Approved, Investigational, Withdrawn
ZiprasidoneThe serum concentration of Ziprasidone can be decreased when it is combined with Enzalutamide.Approved
ZolpidemThe serum concentration of Zolpidem can be decreased when it is combined with Enzalutamide.Approved
ZomepiracThe serum concentration of Zomepirac can be decreased when it is combined with Enzalutamide.Withdrawn
ZonisamideThe serum concentration of Zonisamide can be decreased when it is combined with Enzalutamide.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be decreased when it is combined with Enzalutamide.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be decreased when it is combined with Enzalutamide.Approved, Investigational
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General References
  1. Nadiminty N, Tummala R, Liu C, Yang J, Lou W, Evans CP, Gao AC: NF-kappaB2/p52 induces resistance to enzalutamide in prostate cancer: role of androgen receptor and its variants. Mol Cancer Ther. 2013 Aug;12(8):1629-37. doi: 10.1158/1535-7163.MCT-13-0027. Epub 2013 May 22. [PubMed:23699654 ]
External Links
ATC CodesL02BB04
AHFS Codes
  • 10:00
PDB EntriesNot Available
FDA labelDownload (393 KB)
MSDSDownload (89.7 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9356
Blood Brain Barrier+0.8514
Caco-2 permeable+0.5219
P-glycoprotein substrateNon-substrate0.7609
P-glycoprotein inhibitor IInhibitor0.6464
P-glycoprotein inhibitor IIInhibitor0.5693
Renal organic cation transporterNon-inhibitor0.899
CYP450 2C9 substrateNon-substrate0.7447
CYP450 2D6 substrateNon-substrate0.8061
CYP450 3A4 substrateSubstrate0.5589
CYP450 1A2 substrateNon-inhibitor0.5613
CYP450 2C9 inhibitorInhibitor0.7126
CYP450 2D6 inhibitorNon-inhibitor0.9148
CYP450 2C19 inhibitorInhibitor0.6882
CYP450 3A4 inhibitorInhibitor0.6184
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.6711
Ames testNon AMES toxic0.683
CarcinogenicityNon-carcinogens0.7232
BiodegradationNot ready biodegradable1.0
Rat acute toxicity2.4319 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9911
hERG inhibition (predictor II)Inhibitor0.7079
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
CapsuleOral40 mg
CapsuleOral40 mg/1
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7709517 No2007-08-132027-08-13Us
US8183274 No2006-05-152026-05-15Us
US9126941 No2006-05-152026-05-15Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
water solubilityInsoluble FDA label
Predicted Properties
PropertyValueSource
Water Solubility0.00136 mg/mLALOGPS
logP3.75ALOGPS
logP4.16ChemAxon
logS-5.5ALOGPS
pKa (Strongest Acidic)13.05ChemAxon
pKa (Strongest Basic)-1.7ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area76.44 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity113.48 m3·mol-1ChemAxon
Polarizability42.71 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenylimidazolidines. These are polycyclic compounds containing an imidazoline substituted by a phenyl group.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassAzolidines
Sub ClassImidazolidines
Direct ParentPhenylimidazolidines
Alternative Parents
Substituents
  • Phenylimidazolidine
  • Halobenzoic acid or derivatives
  • 2-halobenzoic acid or derivatives
  • N-phenylthiourea
  • Aminobenzoic acid or derivatives
  • Benzoic acid or derivatives
  • Benzamide
  • Aminobenzamide
  • Benzoyl
  • Benzonitrile
  • Halobenzene
  • Fluorobenzene
  • Benzenoid
  • Imidazolidinone
  • Monocyclic benzene moiety
  • Aryl halide
  • Aryl fluoride
  • Vinylogous halide
  • Thiourea
  • Tertiary amine
  • Secondary carboxylic acid amide
  • Thiocarbonic acid derivative
  • Carboxamide group
  • Azacycle
  • Nitrile
  • Carbonitrile
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organosulfur compound
  • Organooxygen compound
  • Organonitrogen compound
  • Organofluoride
  • Organohalogen compound
  • Carbonyl group
  • Amine
  • Alkyl halide
  • Alkyl fluoride
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Zinc ion binding
Specific Function:
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Gene Name:
AR
Uniprot ID:
P10275
Molecular Weight:
98987.9 Da

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inducer
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A5
Uniprot ID:
P20815
Molecular Weight:
57108.065 Da

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Toxic substance binding
Specific Function:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Gene Name:
ALB
Uniprot ID:
P02768
Molecular Weight:
69365.94 Da

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
Comments
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Drug created on June 04, 2013 23:12 / Updated on December 09, 2016 02:40