SUVN-502

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
SUVN-502
Accession Number
DB06140
Type
Small Molecule
Groups
Investigational
Description

SUVN-502 is a novel, potent, safe, highly selective and orally active antagonist at a central nervous system serotonin receptor site 5-HT6 intended for treatment of cognitive disorders such as Alzheimer’s and Schizophrenia, an unmet medical need.

Structure
Thumb
Synonyms
Not Available
External IDs
SUVN-502
Product Ingredients
IngredientUNIICASInChI Key
SUVN-502 dimesylateBFE1VOB95D1791396-46-7LOZVXBFXRPRECW-UHFFFAOYSA-N
SUVN-502 dimesylate monohydrate9816MUD84T1791396-45-6XKDCUJBWVGDNSH-UHFFFAOYSA-N
Categories
UNII
8XZ281AO3G
CAS number
701205-60-9
Weight
Average: 478.41
Monoisotopic: 477.072176
Chemical Formula
C21H24BrN3O3S
InChI Key
GWCYPEHWIZXYFZ-UHFFFAOYSA-N
InChI
InChI=1S/C21H24BrN3O3S/c1-23-9-11-24(12-10-23)14-16-15-25(20-8-7-17(28-2)13-18(16)20)29(26,27)21-6-4-3-5-19(21)22/h3-8,13,15H,9-12,14H2,1-2H3
IUPAC Name
1-(2-bromobenzenesulfonyl)-5-methoxy-3-[(4-methylpiperazin-1-yl)methyl]-1H-indole
SMILES
COC1=CC=C2N(C=C(CN3CCN(C)CC3)C2=C1)S(=O)(=O)C1=CC=CC=C1Br

Pharmacology

Indication

Investigated for use/treatment in neurologic disorders.

Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
U5-hydroxytryptamine receptor 6Not AvailableHumans
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
8249313
ChEMBL
CHEMBL4117187

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2Active Not RecruitingTreatmentAlzheimer's Disease (AD)1
Not AvailableAvailableNot AvailableAlzheimer's Disease (AD) / Cognition Disorders / Dementias1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0544 mg/mLALOGPS
logP2.84ALOGPS
logP3.4ChemAxon
logS-3.9ALOGPS
pKa (Strongest Basic)7.79ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area54.78 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity118.84 m3·mol-1ChemAxon
Polarizability46.57 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Serotonin receptor activity
Specific Function
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor ...
Gene Name
HTR6
Uniprot ID
P50406
Uniprot Name
5-hydroxytryptamine receptor 6
Molecular Weight
46953.625 Da

Drug created on November 18, 2007 11:30 / Updated on October 20, 2019 03:03