- Antidepressive Agents
- Accession Number
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
- ATC Classification
Drug Drug Description Tryptophan An amino acid commonly found as a component of total parenteral nutrition. Fluvoxamine A selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. Citalopram A selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression. Reboxetine For the treatment of clinical depression. Venlafaxine A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression. Protriptyline A tricyclic antidepressant that is indicated in the treatment of depression only under close clinical supervision. Mirtazapine A tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite. Imipramine A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. Fluoxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I. Duloxetine A serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence. Nortriptyline A tricyclic antidepressant used in the treatment of depression. Amoxapine A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. Trazodone A serotonin uptake inhibitor used to treat major depressive disorder. Paroxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. Trimipramine A tricyclic antidepressant used to treat depression. Tranylcypromine A monoamine oxidase inhibitor used to treat major depressive disorder. Phenelzine A monoamine oxidase inhibitor used to treat atypical, nonendogenous, or neurotic depression. Minaprine For the treatment of depression Maprotiline A tetracyclic antidepressant used to treat depressive illness, major depressive disorder, bipolar disorder, and anxiety associated with depression. Sertraline A selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions. Doxepin A psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia. Nefazodone An antidepressant used in the treatment of depression. Desipramine A tricyclic antidepressant used in the treatment of depression. Bupropion A norepinephrine and dopamine reuptake inhibitor used in the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and as an aid to smoking cessation. Moclobemide A monoamine oxidase inhibitor used in the treatment of major depressive disorder and bipolar disorder. Escitalopram A selective serotonin re-uptake inhibitor used in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and other select psychiatric disorders such as obsessive-compulsive disorder (OCD). Clomipramine A tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder. Isocarboxazid A monoamine oxidase inhibitor used to treat enduring and debilitating symptoms of depression following inadequate clinical response to other antidepressant drugs. Oxitriptan For use as an antidepressant, appetite suppressant, and sleep aid. Nialamide Withdrawn from the Canadian, US, and UK markets in 1963 due to interactions with food products containing tyrosine. Amineptine For the treatment of depression. Milnacipran A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of fibromyalgia and a short-term treatment of major depressive disorder. Mianserin For the treatment of depression. Vilazodone An antidepressant agent used for the treatment of major depressive disorder that targets the 5-HT transporter and 5-HT1A receptors. Desvenlafaxine An antidepressant agent and SNRI used for the treatment of major depressive disorders in adults. Dosulepin Indicated in the treatment of symptoms of depressive illness, especially where an anti-anxiety effect is required. Viloxazine Indicated for the treatment of clinical depression. Toloxatone For the treatment of major depressive disorder. Tianeptine Used primarily in the treatment of major depressive disorder and anxiety . It is currently being studied for fibromyalgia pain treatment . Opipramol Opipramol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders. Gepirone Gepirone has been used in trials studying the treatment of Cocaine-Related Disorders. Dibenzepin Dibenzepin is approved for use in Europe. Lofepramine Not Annotated Iprindole Not Annotated Alaproclate Alaproclate was developed as one of the first selective serotonin reuptake inhibitor (SSRI) antidepressants by Astra AB (now AstraZeneca) in the 1970s. Development was discontinued due to concerns over hepatotoxicity... Bifemelane Not Annotated Amitriptyline A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety. Sulpiride Sulpiride is indicated for the treatment of schizophrenia. Adinazolam For the treatment of anxiety and status epilepticus. Progabide Indicated for the treatment of epilepsy. Sibutramine A norepinephrine, serotonin and dopamine reuptake inhibitor indicated to assist with weight loss in obesity. Lithium cation Lithium is used as a mood stabilizer, and is used for treatment of depression and mania. It is often used in bipolar disorder treatment. Rolipram A phosphodiesterase inhibitor with antidepressant properties. Aniracetam Compound with anti-depressive properties used as a mental performance enhancer. Iproniazid For the treatment of depression (originally intended to treat tuberculosis). Pizotifen A serotonin and tryptamine antagonist indicated for migraine prophylaxis. Dextofisopam Investigated for use/treatment in irritable bowel syndrome (IBS). Saredutant Investigated for use/treatment in depression and anxiety disorders. Esmirtazapine Investigated for use/treatment in insomnia and sleep disorders. Tofisopam For the treatment of anxiety and alcohol withdrawal. Levomilnacipran A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder (MDD). Indalpine Indalpine was one of the first selective serotonin reuptake inhibitors to reach the American market. It was initially marketed by Pharmuka. However, after the emergence of widespread concern regarding adverse... Benactyzine Benactyzine is an anticholinergic drug used as an antidepressant in the treatment of depression and associated anxiety. Benactyzine is no longer widely used in medicine, although it is still a... Pirlindole For the treatment of major depression. It is being studied in the treatment of fibromyalgia pain syndrome. One study determined that the effect of pirlindole on sensorimotor performance while driving... Oxaprotiline Investigated for the treatment of depression. Lanicemine Lanicemine has been used in trials studying the treatment and basic science of Depression, Major Depressive Disorder, and Treatment Resistant Major Depressive Disorder. Orvepitant Orvepitant has been used in trials studying the treatment of Depressive Disorder, Depressive Disorder, Major, Post-Traumatic Stress Disorder, and Posttraumatic Stress Disorder (PTSD). Ritanserin Ritanserin has been used in trials studying the treatment of Cocaine-Related Disorders. Hypericin Hypericin is under investigation for the treatment of Cutaneous T-cell Lymphoma. Deanol Deanol is commonly referred to as 2-(dimethylamino)ethanol, dimethylaminoethanol (DMAE) or dimethylethanolamine (DMEA). It holds tertiary amine and primary alcohol groups as functional groups. Deanol has been used in the treatment... St. John's Wort An herbal ingredient used in non-prescription therapeutic products for the short-term treatment of minor skin irritations, insomnia, depression, and anxiety. Nomifensine Nomifensine, formerly marketed as Merital capsules, was associated with an increased incidence of hemolytic anemia. The approved application holder removed Merital capsules from the market on January 23, 1986. FDA... Zimelidine For the treatment of depression. Agomelatine Agomelatine is indicated to treat major depressive episodes in adults. Dimetacrine Dimetacrine is also known as dimethacrine or acripamine. It is marketed under the names Istonil, Istonyl, Linostil, and Miroistonil. Dimetacrine is a tricyclic antidepressant (TCA) with imipramine-like effects used in... Butriptyline Butriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline. Etoperidone Etoperidone has been studied for the treatment of depression , tremors in Parkinson, extrapyramidal symptoms and male impotence . It is not certain if it was ever approved and marketed... Pivagabine Pivagabine has been used in trials studying the treatment of Stress and Anxiety. Medifoxamine Medifoxamine was marketed as an atypical antidepressant, with anxiolyitc properties in France, Spain, and Morrocco in the 1990s but was later withdrawn from the market due to it causing cases... Quinupramine Quinupramine has been approved in France under the brand name Kinupril, as an antidepressant . Melitracen Not Annotated Oxaflozane Not Annotated Imipramine oxide Not Annotated Dapoxetine For the treatment of premature ejaculation. Amphetamine A CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Reserpine For the treatment of hypertension Mazindol A sympathomimetic used to treat obesity in combination with lifestyle modifications. Benzphetamine A sympathomimetic used to manage exogenous obesity short term. Midomafetamine Clinical trials are now testing the therapeutic potential of MDMA for post-traumatic stress disorder (PTSD) and anxiety associated with terminal cancer. MDMA is one of the four most widely used... Tenamfetamine An amphetamine derivative that inhibits uptake of catecholamine neurotransmitters. It is a hallucinogen. It is less toxic than its methylated derivative but in sufficient doses may still destroy serotonergic neurons... Metamfetamine A sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity. Edivoxetine Edivoxetine is a drug which acts as a selective norepinephrine reuptake inhibitor and is currently under development by Eli Lilly for attention-deficit hyperactivity disorder (ADHD) and as an antidepressant treatment.... Amitriptylinoxide Amitriptylinoxide has been used in trials studying Major Depression. Selegiline A monoamine oxidase inhibitor used to treat major depressive disorder and Parkinson's. Rasagiline An irreversible inhibitor of monoamine oxidase used for the symptomatic management of idiopathic Parkinson's disease as initial monotherapy and as adjunct therapy to levodopa. Pargyline For the treatment of moderate to severe hypertension. Hydracarbazine Was used for the treatment of hypertension . Methylene blue An oxidation-reduction agent used for the treatment of pediatric and adult patients with acquired methemoglobinemia. Benmoxin For the treatment of depression. Mebanazine For the treatment of depression. Octamoxin For the treatment of depression. Pheniprazine For the treatment of depression, schizophrenia, and angina pectoris. Phenoxypropazine For the treatment of depression. Pivhydrazine For the treatment of depression. Safrazine For the treatment of depression. Caroxazone For the treatment of depression. Furazolidone For the specific and symptomatic treatment of bacterial or protozoal diarrhea and enteritis caused by susceptible organisms. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline Potent reversible inhibitor of phenylethanolamine N-methyltransferase. Harmaline Not Annotated Brofaromine Not Annotated Procaine A local anesthetic used for anesthesia, peripheral nerve block, and spinal nerve block. Procarbazine An antineoplastic agent indicated for the treatment of stage III and stage IV Hodgkin's disease in combination with other chemotherapeutic agents. Vortioxetine An atypical antipsychotic and antidepressant indicated for the treatment of major depressive disorder (MDD). Esreboxetine Esreboxetine has been used in trials studying the treatment and basic science of Fibromyalgia. Lortalamine Lortalamine (LM-1404) is a selective norepinephrine reuptake inhibitor developed in the 1980s. This drug never made it past clinical trials, likely due to ocular toxicity in animals, but has been... Nisoxetine Nisoxetine is a selective norepinephrine reuptake inhibitor (SNRI) developed in the 1970s. It was originally investigated as an antidepressant but has no current clinical applications aside from being a research... Talopram Talopram is a selective norepinephrine reuptake inhibitor (SNRI) that is structurally similar to citalopram and melitracen. It was researched in the 1960s and 1970s but never marketed. Lithium carbonate A medication used to treat manic episodes of bipolar disorder. Linezolid An oxazolidinone antibiotic used to treat susceptible strains of multidrug resistant bacterial infections. Safinamide A MAO-B inhibitor used as an add-on treatment to levodopa/carbidopa for Parkinson's disease during "off" episodes. Iproclozide For the treatment of depression. Eletriptan A triptan used for the treatment of migraines. Ziprasidone An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia. Methysergide An ergot alkaloid used for the prophylaxis of migraine and cluster headaches. Zolmitriptan A triptan drug used for the acute treatment of migraine. Olanzapine An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders. Palonosetron A serotonin antagonist used in the prophylaxis or management of vomiting that results from emetogenic chemotherapy, and for the management of postoperative nausea and vomiting. Cyproheptadine A serotonin and histamine antagonist used in the treatment of allergy symptoms and in combination with epinephrine in the treatment of anaphylaxis. Fenfluramine An appetite suppressant used to assist in weight loss for obese patients. Lisuride For the management of Parkinson's Disease Sumatriptan A serotonin receptor agonist used to treat migraines and cluster headaches. Ergotamine A alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. Risperidone A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. Dolasetron An antinauseant and antiemetic used in chemotherapy and postoperatively. Granisetron A 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively. Ondansetron A serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively. Almotriptan A 5-HT1B/1D receptor agonist used to treat migraines. Naratriptan A 5-HT1B/1D receptor agonist used to treat migraines. Rizatriptan A 5-HT1B/1D receptor agonist used to treat migraines. Pindolol A beta adrenoceptor antagonist used to treat hypertension, edema, ventricular tachycardias, and atrial fibrillation. Alosetron A 5-HT3 antagonist used to treat diarrhea-predominant IBS. Frovatriptan A 5-HT1B/1D receptor agonist used to treat migraines. 4-Bromo-2,5-dimethoxyamphetamine Not Available Dimethyltryptamine Some people use this compound as a psychedelic inducing agent. Lysergic acid diethylamide Debate continues over the nature and causes of chronic flashbacks. Explanations in terms of LSD physically remaining in the body for months or years after consumption have been discounted by... Renzapride For the treatment of constipation-predominant irritable bowel syndrome (IBS-C). APD791 For the treatment and prophylaxis of arterial thrombosis. Pimavanserin A second generation atypical antipsychotic used for the treatment of hallucinations and delusions caused by Parkinson's Disease. Naronapride Investigated for use/treatment in gastroesophageal reflux disease (GERD) and gastroparesis. Naluzotan Investigated for use/treatment in anxiety disorders and depression. YKP-1358 Investigated for use/treatment in schizophrenia and schizoaffective disorders. Dotarizine Investigated for use/treatment in migraine and cluster headaches. Deramciclane Investigated for use/treatment in anxiety disorders. Lurasidone An atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. Serotonin For temporary relief of nervousness, anxiety, mood swings, joint pains, weakness, drowsiness, itching and lethargy. Not evaluated by the FDA, homeopathic product. Amperozide Amperozide is a diphenylbutylpiperazine atypical antipsychotic which antagonizes 5-HT2A receptors. It inhibits dopamine release and alters the firing of dopaminergic neurons. Investigations regarding the use of the agent revolved primarily... Brexpiprazole A serotonin–dopamine activity modulator used in the treatment of major depressive disorder as an adjunct and schizophrenia. Ramosetron For the treatment of nausea and vomiting and diarrhea-predominant irritable bowel syndrome in males. Mosapride Mosapride is under investigation for the treatment and prevention of Postoperative Ileus and Gastric Peroral Endoscopic Pyloromyotomy (G-POEM). Mosapride has been investigated for the treatment and diagnostic of Constipation, Type... Tropisetron For the prevention of nausea and vomiting induced by cytotoxic therapy and postoperative. m-Chlorophenylpiperazine m-Chlorophenylpiperazine has been used in trials studying the treatment of Alcoholism. MK-212 MK-212 has been used in trials studying the treatment of Alcoholism. Sarpogrelate Sarpogrelate has been investigated for the treatment of Diabetes Mellitus, Diabetic Nephropathy, Coronary Artery Disease, and Renal Insufficiency, Chronic. Eplivanserin Eplivanserin has been used in trials studying the treatment of Sleep, Insomnia, Chronic Pain, Fibromyalgia, and Primary Insomnia, among others. Piclozotan Piclozotan has been investigated for the treatment of Parkinson's Disease. Ketanserin Ketanserin has been investigated for the treatment of Septic Shock, Severe Sepsis, and Diabetic Foot Ulcer. Urapidil Urapidil has been investigated for the treatment of Hypertension During Pre-Eclampsia. Tandospirone Tandospirone has been used in trials studying the treatment of Schizophrenia. Eltoprazine Eltoprazine has been used in trials studying the treatment of Schizophrenia and Cognitive Impairment. Metergoline Metergoline is an ergot-derived psychoactive drug that acts as a ligand for serotonin and dopamine receptors. Metergoline is an antagonist at various 5-HT receptor subtypes at a relatively low concentration... Iprazochrome Not Annotated Naftidrofuryl Not Annotated Wortmannin Wortmannin is a steroid metabolite of Penicillium funiculosum and Talaromyces wortmannii fungi. This drug acts as a nonspecific, covalent inhibitor of phosphoinositide 3-kinase enzymes (PI3Ks). Meperidine An opioid agonist with analgesic and sedative properties used to manage severe pain. Tramadol A centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults. Dextromethorphan An NMDA receptor antagonist used to treat cases of dry cough. Methadone An opioid analgesic indicated for management of severe pain that is not responsive to alternative treatments. Also used to aid in detoxification and maintenance treatment of opioid addiction. Dihydroergotamine An ergot alkaloid used in the acute treatment of migraine headache and cluster headache. Cabergoline A dopamine receptor agonist used for the treatment of hyperprolactinemic conditions due to various causes. Ropinirole A non-ergoline dopamine agonist used to treat the symptoms of Parkinson's disease and Restless Legs Syndrome. Flibanserin A 5-HT receptor modulator used for the treatment of selected premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD). Rotigotine A non-selective dopamine agonist used for the treatment of Parkinson's Disease and Restless Leg Syndrome. Cinitapride It is indicated to treat gastrointestinal disorders associated with motility disturbances like gastroesophageal reflux disease (GERD), non-ulcer dyspepsia and delayed gastric emptying. Cariprazine An atypical antipsychotic used to treat schizophrenia and acute manic or mixed episodes due to bipolar I disorder. 5-methoxy-N,N-dimethyltryptamine 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a tryptamine with psychedelic properties. It is found in a wide variety of plant species, and a single psychoactive toad species, the Colorado River toad. This drug,... Tetrahydrocannabivarin THCV does not currently have any FDA, Health Canada, or EMA approved indications. Pergolide A long-acting dopamine agonist that is uncommonly used for the management of Parkinson's disease, due to the risk for cardiac valvulopathy. Bromocriptine A dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome. MMDA MMDA is a recreational drug. It has no current medical uses and is a Schedule I controlled substance in the USA at present. 2,5-Dimethoxy-4-ethylthioamphetamine 2,5-Dimethoxy-4-ethylthioamphetamine (ALEPH-2) is a phenylisopropylamine derivative with alleged anxiolytic and hallucinogenic properties. N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine 25CN-NBOH (N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine) is a newly developed selective 5-HT2A agonist. It has been tested with regard to the head-twitch-response (HTR) model of 5-HT2A activity and effects on locomotion . It was... Lofexidine A centrally acting alpha2-adrenergic agonist used for the symptomatic treatment of acute opioid withdrawal syndrome to facilitate abrupt opioid discontinuation in adults. TD-8954 TD-8954 has been used in trials studying the treatment of Enteral Feeding Intolerance and Gastrointestinal Motility Disorder. Lorcaserin A serotonin 2C receptor agonist used in conjunction with physical activity and calorie restriction for weight loss in obese patients with a body mass index (BMI) of 30 and above, and in overweight patients with weight-related comorbidities. Vabicaserin Vabicaserin has been used in trials studying the health services research and treatment of Schizophrenia. Cannabidiol An active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer. Iferanserin Iferanserin has been investigated for the treatment of Hemorrhoids. Idalopirdine Idalopirdine has been used in trials studying the treatment of Cognition, Schizophrenia, and Alzheimer's Disease. Cerlapirdine Cerlapirdine has been investigated for the treatment of Alzheimer Disease. Cilansetron For the treatment of symptoms associated with irritable bowel syndrome. Triflupromazine Used mainly in the management of psychoses. Also used to control nausea and vomiting. Chlorprothixene For treatment of psychotic disorders (e.g. schizophrenia) and of acute mania occuring as part of bipolar disorders. Yohimbine An alpha-2-adrenergic blocker and sympatholytic found in supplements used to. PRX-08066 Investigated for use/treatment in chronic obstructive pulmonary disease (COPD) and pulmonary hypertension. Quetiapine A psychotropic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder. Promazine A phenothiazine used to manage schizophrenia. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Thioridazine A phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. Propiomazine Propiomazine is largely used for its antihistamininc sleep inducing effects in treating insomnia. Mesoridazine A phenothiazine antipsychotic used to treat schizophrenia, organic brain disorders, alcoholism, and psychoneuroses. Aripiprazole An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. Epinastine An H1 receptor antagonist used to prevent itching in allergic conjunctivitis. Sertindole Used in the treatment of schizophrenia. Iloperidone An atypical antipsychotic agent used for the acute treatment of schizophrenia in adults. Flupentixol A thioxanthene neuroleptic used to treat schizophrenia and depression. Methotrimeprazine A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. Zuclopenthixol An antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance. Loxapine A antipsychotic used for the treatment of schizophrenia. Fluspirilene An antipsychotic agent used in the treatment of schizophrenia. Acepromazine Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and... Thioproperazine An antipsychotic indicated for the management of acute and chronic schizophrenia, including cases that are refractory to more common neuroleptics. May also be used to treat manic syndromes. Blonanserin Used for the treatment of schizophrenia . Zotepine Zotepine, like other atypical antipsychotics, is considered as the first-line treatment in newly diagnosed schizophrenia. It is usually thought to be an option of choice for managing acute schizophrenic episodes... Captodiame Captodiame is indicated for the treatment of anxiety. Alprenolol For the treatment of hypertension, angina, and arrhythmia Alverine Used to relieve cramps or spasms of the stomach and intestines. It is also useful in treating irritable bowel syndrome (IBS) and similar conditions. It can also be used to... Penbutolol A beta-adrenergic antagonist used for the management of mild to moderate arterial hypertension, alone or in combination with other antihypertensive agents. Aripiprazole lauroxil An antipsychotic used to treat schizophrenia in adults. Fentanyl An opioid analgesic used in anesthesia, for breakthrough cancer pain, or round the clock pain management. Ergoloid mesylate A nootropic with an unknown mechanism of action indicated in individuals over sixty who manifest signs and symptoms of an idiopathic decline in mental capacity. Ergometrine An ergot alkaloid used for the treatment of postpartum haemorrhage and post abortion hemorrhage in patients with uterine atony. Tapentadol An opioid used to manage severe pain that has not responded to non-opioid medications, and for which opioid analgesic therapy is appropriate. Tedizolid phosphate An antibiotic agent used to treat acute bacterial skin and skin structure infections caused by susceptible isolates of Gram-positive bacteria. Chlorpheniramine A histamine-H1 receptor antagonist indicated for the management of symptoms associated with upper respiratory allergies. Dexmethylphenidate A norepinephrine-dopamine reuptake inhibitor used in the treatment of ADHD in conjunction with other therapies. Clozapine An antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Paliperidone An atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders. Pipamperone Treatment of chronic psychoses and states of aggressiveness of various origins . Cisapride A medication used to treat heartburn associated with GERD. Asenapine An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. Apomorphine A morphine derivative D2 dopamine agonist used to treat hypomobile "off" episodes of advanced Parkinson's disease. Promethazine A first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness. Clorgiline An antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE. Seproxetine Seproxetine is also known as (S)-norfluoxetine. It is a selective serotonin reuptake inhibitor (SSRI). It is an active metabolite of fluoxetine. Seproxetine was being investigated by Eli Lilly as an... Solriamfetol Solriamfetol is indicated for treatment of daytime sleepiness associated with obstructive sleep apnea and narcolepsy, but is not a treatment for the underlying airway obstruction in apnea patients[FDA Label][A176534,A176744]. Amisulpride Investigated for use/treatment in schizophrenia and schizoaffective disorders, mania in bipolar disorder, and depression. Esketamine A NMDA receptor antagonist used for treatment-resistant depression. Sultopride Sultopride is used in Japan, Hong Kong, and Europe to treat schizophrenia. It is of the drug class atypical antipsychotics . Brilaroxazine Investigated for the treatment of schizophrenia and schizoaffective disorder. Lithium citrate f Zuranolone Not Annotated Lorpiprazole In 2016, lorpiprazole was classified in the "Chemical structure-related drug-like criteria of global approved drugs" as an antipsychotic and anxiolytic. An antipsychotic is a medication used to treat a state... Lumateperone A novel 2nd generation antipsychotic used to manage both positive and negative symptoms in patients with schizophrenia. Harmine Not Available Amibegron Investigated for use/treatment in depression, irritable bowel syndrome (IBS), and obesity.
- Drugs & Drug Targets