Identification

Name
Netupitant
Accession Number
DB09048
Type
Small Molecule
Groups
Approved
Description

Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug is marketed by Eisai Inc. and Helsinn Therapeutics (U.S.) Inc. under the brand Akynzeo®.

Structure
Thumb
Synonyms
  • 2-[3,5-Bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]propanamide
External IDs
RO 67-3189/000
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
AkynzeoNetupitant (300 mg/1) + Palonosetron Hydrochloride (.5 mg/1)CapsuleOralHelsinn Therapeutics (U.S.), Inc2014-10-13Not applicableUs
AkynzeoNetupitant (300 mg/1) + Palonosetron Hydrochloride (.5 mg/1)CapsuleOralEisai Limited2014-10-132018-05-31Us
AkynzeoNetupitant (300 mg) + Palonosetron (0.5 mg)CapsuleOralPurdue PharmaNot applicableNot applicableCanada
Categories
UNII
7732P08TIR
CAS number
290297-26-6
Weight
Average: 578.603
Monoisotopic: 578.248030644
Chemical Formula
C30H32F6N4O
InChI Key
WAXQNWCZJDTGBU-UHFFFAOYSA-N
InChI
InChI=1S/C30H32F6N4O/c1-19-8-6-7-9-23(19)24-17-26(40-12-10-38(4)11-13-40)37-18-25(24)39(5)27(41)28(2,3)20-14-21(29(31,32)33)16-22(15-20)30(34,35)36/h6-9,14-18H,10-13H2,1-5H3
IUPAC Name
2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide
SMILES
CN(C(=O)C(C)(C)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)C1=CN=C(C=C1C1=CC=CC=C1C)N1CCN(C)CC1

Pharmacology

Indication

Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy.

Structured Indications
Pharmacodynamics
Not Available
Mechanism of action

Delayed emesis (vomiting) has been largely associated with the activation of tachykinin family neurokinin 1 (NK1) receptors (broadly distributed in the central and peripheral nervous systems) by substance P. As shown in in vitro and in vivo studies, netupitant inhibits substance P mediated responses.

TargetActionsOrganism
ASubstance-P receptor
antagonist
Human
Absorption

Upon oral administration of a single dose of netupitant, netupitant started to be measurable in plasma between 15 minutes and 3 hours after dosing. Plasma concentrations reached Cmax in approximately 5 hours. There was a greater than dose-proportional increase in the systemic exposure with the dose increase from 10 mg to 300 mg and a dose-proportional increase in systemic exposure with a dose increase from 300 mg to 450 mg.

Volume of distribution

In cancer patients, Vz/F: 1982 ± 906 L (mean ± SD).

Protein binding

> 99.5% at drug concentrations ranging from 10-1300 ng/mL.

Metabolism

Once absorbed, netupitant is extensively metabolized to form three major metabolites: desmethyl derivative, M1; N-oxide derivative, M2; and OH-methyl derivative, M3. Metabolism is mediated primarily by CYP3A4 and to a lesser extent by CYP2C9 and CYP2D6. Metabolites M1, M2 and M3 were shown to bind to the substance P/neurokinin 1 (NK1) receptor.

Route of elimination

Primarily fecal.

Half life

96 hours with CV% of 61.

Clearance

estimated systemic clearance of 20.3 ± 9.2 L/h (mean ± SD).

Toxicity

Daily oral administration of netupitant in rats at doses up to 30 mg/kg (1.9 times the human AUC in male rats and 3.7 times the human AUC in female rats at the recommended human dose) had no effects on fertility or reproductive performance.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AbirateroneThe serum concentration of Netupitant can be increased when it is combined with Abiraterone.Approved
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Netupitant.Approved
AcetaminophenThe serum concentration of Acetaminophen can be increased when it is combined with Netupitant.Approved
AdinazolamThe serum concentration of Adinazolam can be increased when it is combined with Netupitant.Approved
AlbendazoleThe serum concentration of Albendazole can be increased when it is combined with Netupitant.Approved, Vet Approved
AlclometasoneThe serum concentration of Alclometasone can be increased when it is combined with Netupitant.Approved
AlfentanilThe serum concentration of Alfentanil can be increased when it is combined with Netupitant.Approved, Illicit
AlfuzosinThe serum concentration of Alfuzosin can be increased when it is combined with Netupitant.Approved, Investigational
AliskirenThe serum concentration of Aliskiren can be increased when it is combined with Netupitant.Approved, Investigational
AllylestrenolThe serum concentration of Allylestrenol can be increased when it is combined with Netupitant.Approved
AlmotriptanThe serum concentration of Almotriptan can be increased when it is combined with Netupitant.Approved, Investigational
AlogliptinThe serum concentration of Alogliptin can be increased when it is combined with Netupitant.Approved
AlosetronThe serum concentration of Alosetron can be increased when it is combined with Netupitant.Approved, Withdrawn
AlprazolamThe serum concentration of Alprazolam can be increased when it is combined with Netupitant.Approved, Illicit, Investigational
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Netupitant.Approved, Investigational
AmbroxolThe serum concentration of Ambroxol can be increased when it is combined with Netupitant.Approved, Investigational
AminophenazoneThe serum concentration of Aminophenazone can be increased when it is combined with Netupitant.Approved, Withdrawn
AminophyllineThe serum concentration of Aminophylline can be increased when it is combined with Netupitant.Approved
AmiodaroneThe serum concentration of Amiodarone can be increased when it is combined with Netupitant.Approved, Investigational
AmitriptylineThe serum concentration of Amitriptyline can be increased when it is combined with Netupitant.Approved
AmlodipineThe serum concentration of Amlodipine can be increased when it is combined with Netupitant.Approved
AmprenavirThe serum concentration of Amprenavir can be increased when it is combined with Netupitant.Approved
AntipyrineThe serum concentration of Antipyrine can be increased when it is combined with Netupitant.Approved
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Netupitant.Approved
ApremilastThe serum concentration of Apremilast can be increased when it is combined with Netupitant.Approved, Investigational
AprepitantThe serum concentration of Aprepitant can be increased when it is combined with Netupitant.Approved, Investigational
ArgatrobanThe serum concentration of Argatroban can be increased when it is combined with Netupitant.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Netupitant.Approved, Investigational
ArtemetherThe serum concentration of Artemether can be increased when it is combined with Netupitant.Approved
AsenapineThe serum concentration of Asenapine can be increased when it is combined with Netupitant.Approved
AstemizoleThe serum concentration of Astemizole can be increased when it is combined with Netupitant.Approved, Withdrawn
AtazanavirThe serum concentration of Atazanavir can be increased when it is combined with Netupitant.Approved, Investigational
AtomoxetineThe metabolism of Netupitant can be decreased when combined with Atomoxetine.Approved
AtorvastatinThe risk or severity of adverse effects can be increased when Netupitant is combined with Atorvastatin.Approved
AvanafilThe serum concentration of Avanafil can be increased when it is combined with Netupitant.Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Netupitant.Approved, Investigational
AzelastineThe serum concentration of Azelastine can be increased when it is combined with Netupitant.Approved
AzithromycinThe serum concentration of Azithromycin can be increased when it is combined with Netupitant.Approved
BanoxantroneThe serum concentration of Banoxantrone can be increased when it is combined with Netupitant.Investigational
BedaquilineThe serum concentration of Bedaquiline can be increased when it is combined with Netupitant.Approved
BenzphetamineThe serum concentration of Benzphetamine can be increased when it is combined with Netupitant.Approved, Illicit
Benzyl alcoholThe serum concentration of Benzyl alcohol can be increased when it is combined with Netupitant.Approved
BetaxololThe metabolism of Netupitant can be decreased when combined with Betaxolol.Approved
BexaroteneThe serum concentration of Bexarotene can be increased when it is combined with Netupitant.Approved, Investigational
BezafibrateThe serum concentration of Bezafibrate can be increased when it is combined with Netupitant.Approved
BicalutamideThe serum concentration of Bicalutamide can be increased when it is combined with Netupitant.Approved
BisoprololThe serum concentration of Bisoprolol can be increased when it is combined with Netupitant.Approved
BoceprevirThe serum concentration of Boceprevir can be increased when it is combined with Netupitant.Approved, Withdrawn
BortezomibThe serum concentration of Bortezomib can be increased when it is combined with Netupitant.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Netupitant.Approved, Investigational
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Netupitant.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Netupitant.Approved
BrinzolamideThe serum concentration of Brinzolamide can be increased when it is combined with Netupitant.Approved
BrivaracetamThe serum concentration of Brivaracetam can be increased when it is combined with Netupitant.Approved, Investigational
BromazepamThe serum concentration of Bromazepam can be increased when it is combined with Netupitant.Approved, Illicit
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Netupitant.Approved, Investigational
BrompheniramineThe serum concentration of Brompheniramine can be increased when it is combined with Netupitant.Approved
BudesonideThe serum concentration of Budesonide can be increased when it is combined with Netupitant.Approved
BupivacaineThe serum concentration of Bupivacaine can be increased when it is combined with Netupitant.Approved, Investigational
BuprenorphineThe serum concentration of Buprenorphine can be increased when it is combined with Netupitant.Approved, Illicit, Investigational, Vet Approved
BupropionThe serum concentration of Bupropion can be increased when it is combined with Netupitant.Approved
BuspironeThe serum concentration of Buspirone can be increased when it is combined with Netupitant.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Netupitant.Approved, Investigational
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Netupitant.Approved
CabergolineThe serum concentration of Cabergoline can be increased when it is combined with Netupitant.Approved
CabozantinibThe serum concentration of Cabozantinib can be increased when it is combined with Netupitant.Approved
CaffeineThe serum concentration of Caffeine can be increased when it is combined with Netupitant.Approved
CalcitriolThe serum concentration of Calcitriol can be increased when it is combined with Netupitant.Approved, Nutraceutical
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Netupitant.Approved
CapecitabineThe metabolism of Netupitant can be decreased when combined with Capecitabine.Approved, Investigational
CarbamazepineThe serum concentration of Carbamazepine can be increased when it is combined with Netupitant.Approved, Investigational
CarbinoxamineThe serum concentration of Carbinoxamine can be increased when it is combined with Netupitant.Approved
CariprazineThe serum concentration of Cariprazine can be increased when it is combined with Netupitant.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Netupitant.Approved, Investigational
CelecoxibThe serum concentration of Celecoxib can be increased when it is combined with Netupitant.Approved, Investigational
CeliprololThe serum concentration of Celiprolol can be increased when it is combined with Netupitant.Approved, Investigational
CephalexinThe serum concentration of Cephalexin can be increased when it is combined with Netupitant.Approved, Vet Approved
CeritinibThe serum concentration of Netupitant can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Netupitant.Withdrawn
CevimelineThe serum concentration of Cevimeline can be increased when it is combined with Netupitant.Approved
Chenodeoxycholic acidThe serum concentration of Chenodeoxycholic acid can be increased when it is combined with Netupitant.Approved
ChlordiazepoxideThe serum concentration of Chlordiazepoxide can be increased when it is combined with Netupitant.Approved, Illicit
ChloroquineThe serum concentration of Chloroquine can be increased when it is combined with Netupitant.Approved, Vet Approved
ChlorphenamineThe serum concentration of Chlorphenamine can be increased when it is combined with Netupitant.Approved
ChlorpromazineThe serum concentration of Chlorpromazine can be increased when it is combined with Netupitant.Approved, Vet Approved
ChlorzoxazoneThe serum concentration of Chlorzoxazone can be increased when it is combined with Netupitant.Approved
CholecalciferolThe serum concentration of Cholecalciferol can be increased when it is combined with Netupitant.Approved, Nutraceutical
CiclesonideThe serum concentration of Ciclesonide can be increased when it is combined with Netupitant.Approved, Investigational
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Netupitant.Approved
CimetidineThe metabolism of Netupitant can be decreased when combined with Cimetidine.Approved
CinacalcetThe serum concentration of Cinacalcet can be increased when it is combined with Netupitant.Approved
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Netupitant.Approved, Investigational, Withdrawn
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Netupitant.Approved
ClarithromycinThe serum concentration of Clarithromycin can be increased when it is combined with Netupitant.Approved
ClemastineThe metabolism of Netupitant can be decreased when combined with Clemastine.Approved
ClindamycinThe serum concentration of Clindamycin can be increased when it is combined with Netupitant.Approved, Vet Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Netupitant.Approved, Illicit
ClofazimineThe serum concentration of Clofazimine can be increased when it is combined with Netupitant.Approved, Investigational
ClofibrateThe serum concentration of Clofibrate can be increased when it is combined with Netupitant.Approved, Investigational
clomethiazoleThe serum concentration of clomethiazole can be increased when it is combined with Netupitant.Investigational
ClomipramineThe serum concentration of Clomipramine can be increased when it is combined with Netupitant.Approved, Vet Approved
ClonazepamThe serum concentration of Clonazepam can be increased when it is combined with Netupitant.Approved, Illicit
ClonidineThe serum concentration of Clonidine can be increased when it is combined with Netupitant.Approved
ClopidogrelThe serum concentration of Clopidogrel can be increased when it is combined with Netupitant.Approved, Nutraceutical
ClorazepateThe serum concentration of Clorazepate can be increased when it is combined with Netupitant.Approved, Illicit
ClotiazepamThe serum concentration of Clotiazepam can be increased when it is combined with Netupitant.Approved, Illicit
ClotrimazoleThe metabolism of Netupitant can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be increased when it is combined with Netupitant.Approved
CobicistatThe serum concentration of Netupitant can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Netupitant.Approved
CocaineThe serum concentration of Cocaine can be increased when it is combined with Netupitant.Approved, Illicit
CodeineThe serum concentration of Codeine can be increased when it is combined with Netupitant.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Netupitant.Approved
ConivaptanThe serum concentration of Conivaptan can be increased when it is combined with Netupitant.Approved, Investigational
Conjugated estrogensThe serum concentration of Conjugated estrogens can be increased when it is combined with Netupitant.Approved
CopanlisibThe serum concentration of Copanlisib can be increased when it is combined with Netupitant.Approved
Cortisone acetateThe serum concentration of Cortisone acetate can be increased when it is combined with Netupitant.Approved
CrisaboroleThe metabolism of Netupitant can be decreased when combined with Crisaborole.Approved
CrizotinibThe serum concentration of Crizotinib can be increased when it is combined with Netupitant.Approved
CyclobenzaprineThe serum concentration of Cyclobenzaprine can be increased when it is combined with Netupitant.Approved
CyclophosphamideThe serum concentration of Cyclophosphamide can be increased when it is combined with Netupitant.Approved, Investigational
CyclosporineThe serum concentration of Cyclosporine can be increased when it is combined with Netupitant.Approved, Investigational, Vet Approved
CytarabineThe serum concentration of Cytarabine can be increased when it is combined with Netupitant.Approved, Investigational
DabrafenibThe serum concentration of Netupitant can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Daclatasvir can be increased when it is combined with Netupitant.Approved
DantroleneThe serum concentration of Dantrolene can be increased when it is combined with Netupitant.Approved
DapagliflozinThe serum concentration of Dapagliflozin can be increased when it is combined with Netupitant.Approved
DapoxetineThe serum concentration of Dapoxetine can be increased when it is combined with Netupitant.Investigational
DapsoneThe serum concentration of Dapsone can be increased when it is combined with Netupitant.Approved, Investigational
DarifenacinThe serum concentration of Darifenacin can be increased when it is combined with Netupitant.Approved, Investigational
DarunavirThe serum concentration of Darunavir can be increased when it is combined with Netupitant.Approved
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Netupitant.Approved
DasatinibThe serum concentration of Dasatinib can be increased when it is combined with Netupitant.Approved, Investigational
DaunorubicinThe serum concentration of Daunorubicin can be increased when it is combined with Netupitant.Approved
DeflazacortThe serum concentration of Deflazacort can be increased when it is combined with Netupitant.Approved
DelavirdineThe serum concentration of Delavirdine can be increased when it is combined with Netupitant.Approved
DesipramineThe metabolism of Netupitant can be decreased when combined with Desipramine.Approved
DesvenlafaxineThe serum concentration of Desvenlafaxine can be increased when it is combined with Netupitant.Approved
DeutetrabenazineThe serum concentration of Deutetrabenazine can be increased when it is combined with Netupitant.Approved, Investigational
DexamethasoneThe serum concentration of Dexamethasone can be increased when it is combined with Netupitant.Approved, Investigational, Vet Approved
Dexchlorpheniramine maleateThe serum concentration of Dexchlorpheniramine maleate can be increased when it is combined with Netupitant.Approved
DexlansoprazoleThe serum concentration of Dexlansoprazole can be increased when it is combined with Netupitant.Approved
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Netupitant.Approved
DextropropoxypheneThe serum concentration of Dextropropoxyphene can be increased when it is combined with Netupitant.Approved, Illicit, Investigational, Withdrawn
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Netupitant.Approved, Illicit, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Netupitant.Approved, Vet Approved
DienogestThe serum concentration of Dienogest can be increased when it is combined with Netupitant.Approved
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Netupitant.Approved, Investigational
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Netupitant.Approved
DihydrocodeineThe serum concentration of Dihydrocodeine can be increased when it is combined with Netupitant.Approved, Illicit
DihydroergocornineThe risk or severity of adverse effects can be increased when Dihydroergocornine is combined with Netupitant.Approved
DihydroergocristineThe risk or severity of adverse effects can be increased when Dihydroergocristine is combined with Netupitant.Experimental
DihydroergocryptineThe risk or severity of adverse effects can be increased when Dihydroergocryptine is combined with Netupitant.Experimental
DihydroergotamineThe serum concentration of Dihydroergotamine can be increased when it is combined with Netupitant.Approved
DiltiazemThe serum concentration of Diltiazem can be increased when it is combined with Netupitant.Approved
DiphenhydramineThe metabolism of Netupitant can be decreased when combined with Diphenhydramine.Approved
DisopyramideThe serum concentration of Disopyramide can be increased when it is combined with Netupitant.Approved
DisulfiramThe serum concentration of Disulfiram can be increased when it is combined with Netupitant.Approved
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Netupitant.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Netupitant.Approved
DolasetronThe serum concentration of Dolasetron can be increased when it is combined with Netupitant.Approved
DonepezilThe serum concentration of Donepezil can be increased when it is combined with Netupitant.Approved
DorzolamideThe serum concentration of Dorzolamide can be increased when it is combined with Netupitant.Approved
DosulepinThe metabolism of Netupitant can be decreased when combined with Dosulepin.Approved
DoxepinThe serum concentration of Doxepin can be increased when it is combined with Netupitant.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Netupitant.Approved, Investigational
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Netupitant.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be increased when it is combined with Netupitant.Approved
DuloxetineThe metabolism of Netupitant can be decreased when combined with Duloxetine.Approved
DutasterideThe serum concentration of Dutasteride can be increased when it is combined with Netupitant.Approved, Investigational
EfavirenzThe serum concentration of Efavirenz can be increased when it is combined with Netupitant.Approved, Investigational
ElbasvirThe serum concentration of Elbasvir can be increased when it is combined with Netupitant.Approved
EletriptanThe serum concentration of Eletriptan can be increased when it is combined with Netupitant.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Netupitant.Approved
ElvitegravirThe serum concentration of Elvitegravir can be increased when it is combined with Netupitant.Approved
EnalaprilThe serum concentration of Enalapril can be increased when it is combined with Netupitant.Approved, Vet Approved
EnasidenibThe serum concentration of Enasidenib can be increased when it is combined with Netupitant.Approved
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Netupitant.Approved
EpinastineThe serum concentration of Epinastine can be increased when it is combined with Netupitant.Approved, Investigational
EplerenoneThe serum concentration of Eplerenone can be increased when it is combined with Netupitant.Approved
ErgocalciferolThe serum concentration of Ergocalciferol can be increased when it is combined with Netupitant.Approved, Nutraceutical
Ergoloid mesylateThe serum concentration of Ergoloid mesylate can be increased when it is combined with Netupitant.Approved
ErgonovineThe serum concentration of Ergonovine can be increased when it is combined with Netupitant.Approved
ErgotamineThe serum concentration of Ergotamine can be increased when it is combined with Netupitant.Approved
ErlotinibThe serum concentration of Erlotinib can be increased when it is combined with Netupitant.Approved, Investigational
ErythromycinThe serum concentration of Erythromycin can be increased when it is combined with Netupitant.Approved, Vet Approved
EscitalopramThe serum concentration of Escitalopram can be increased when it is combined with Netupitant.Approved, Investigational
EsomeprazoleThe serum concentration of Esomeprazole can be increased when it is combined with Netupitant.Approved, Investigational
EstazolamThe serum concentration of Estazolam can be increased when it is combined with Netupitant.Approved, Illicit
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Netupitant.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe serum concentration of Estradiol valerate/Dienogest can be increased when it is combined with Netupitant.Approved, Investigational
EstramustineThe serum concentration of Estramustine can be increased when it is combined with Netupitant.Approved
Estrogens, esterifiedThe serum concentration of Estrogens, esterified can be increased when it is combined with Netupitant.Approved
EstroneThe serum concentration of Estrone can be increased when it is combined with Netupitant.Approved
Estrone sulfateThe serum concentration of Estrone sulfate can be increased when it is combined with Netupitant.Approved
EszopicloneThe serum concentration of Eszopiclone can be increased when it is combined with Netupitant.Approved
EthanolThe serum concentration of Ethanol can be increased when it is combined with Netupitant.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Netupitant.Approved
EthosuximideThe serum concentration of Ethosuximide can be increased when it is combined with Netupitant.Approved
EthylmorphineThe serum concentration of Ethylmorphine can be increased when it is combined with Netupitant.Approved, Illicit
EtizolamThe serum concentration of Etizolam can be increased when it is combined with Netupitant.Approved
EtonogestrelThe serum concentration of Etonogestrel can be increased when it is combined with Netupitant.Approved, Investigational
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Netupitant.Approved
EtoricoxibThe serum concentration of Etoricoxib can be increased when it is combined with Netupitant.Approved, Investigational
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Netupitant.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Netupitant.Approved
ExemestaneThe serum concentration of Exemestane can be increased when it is combined with Netupitant.Approved, Investigational
FamciclovirThe serum concentration of Famciclovir can be increased when it is combined with Netupitant.Approved
FelbamateThe serum concentration of Felbamate can be increased when it is combined with Netupitant.Approved
FelodipineThe serum concentration of Felodipine can be increased when it is combined with Netupitant.Approved, Investigational
FenofibrateThe serum concentration of Fenofibrate can be increased when it is combined with Netupitant.Approved
FentanylThe serum concentration of Fentanyl can be increased when it is combined with Netupitant.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe serum concentration of Fesoterodine can be increased when it is combined with Netupitant.Approved
FinasterideThe serum concentration of Finasteride can be increased when it is combined with Netupitant.Approved
FingolimodThe serum concentration of Fingolimod can be increased when it is combined with Netupitant.Approved, Investigational
FloxuridineThe metabolism of Netupitant can be decreased when combined with Floxuridine.Approved
FluconazoleThe metabolism of Netupitant can be decreased when combined with Fluconazole.Approved
FlunisolideThe serum concentration of Flunisolide can be increased when it is combined with Netupitant.Approved, Investigational
FlunitrazepamThe serum concentration of Flunitrazepam can be increased when it is combined with Netupitant.Approved, Illicit
FluorometholoneThe serum concentration of Fluorometholone can be increased when it is combined with Netupitant.Approved
FluorouracilThe metabolism of Netupitant can be decreased when combined with Fluorouracil.Approved
FluoxetineThe serum concentration of Fluoxetine can be increased when it is combined with Netupitant.Approved, Vet Approved
FlurazepamThe serum concentration of Flurazepam can be increased when it is combined with Netupitant.Approved, Illicit
FlutamideThe serum concentration of Flutamide can be increased when it is combined with Netupitant.Approved
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Netupitant.Approved
Fluticasone propionateThe serum concentration of Fluticasone propionate can be increased when it is combined with Netupitant.Approved
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Netupitant.Approved
FluvoxamineThe metabolism of Netupitant can be decreased when combined with Fluvoxamine.Approved, Investigational
FosamprenavirThe serum concentration of Fosamprenavir can be increased when it is combined with Netupitant.Approved
FosphenytoinThe serum concentration of Netupitant can be decreased when it is combined with Fosphenytoin.Approved
FulvestrantThe serum concentration of Fulvestrant can be increased when it is combined with Netupitant.Approved, Investigational
GalantamineThe serum concentration of Galantamine can be increased when it is combined with Netupitant.Approved
GefitinibThe serum concentration of Gefitinib can be increased when it is combined with Netupitant.Approved, Investigational
GemfibrozilThe serum concentration of Gemfibrozil can be increased when it is combined with Netupitant.Approved
GlipizideThe serum concentration of Glipizide can be increased when it is combined with Netupitant.Approved
GlyburideThe serum concentration of Glyburide can be increased when it is combined with Netupitant.Approved
GranisetronThe serum concentration of Granisetron can be increased when it is combined with Netupitant.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Netupitant.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Netupitant.Investigational, Withdrawn
GuanfacineThe serum concentration of Guanfacine can be increased when it is combined with Netupitant.Approved, Investigational
HalofantrineThe serum concentration of Halofantrine can be increased when it is combined with Netupitant.Approved
HaloperidolThe serum concentration of Haloperidol can be increased when it is combined with Netupitant.Approved
HalothaneThe serum concentration of Halothane can be increased when it is combined with Netupitant.Approved, Vet Approved
HexobarbitalThe serum concentration of Hexobarbital can be increased when it is combined with Netupitant.Approved
HistamineThe serum concentration of Histamine can be increased when it is combined with Netupitant.Approved, Investigational
HydrocodoneThe serum concentration of Hydrocodone can be increased when it is combined with Netupitant.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Netupitant.Approved, Vet Approved
HydromorphoneThe serum concentration of Hydromorphone can be increased when it is combined with Netupitant.Approved, Illicit
Hydroxyprogesterone caproateThe serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Netupitant.Approved
IcotinibThe serum concentration of Icotinib can be increased when it is combined with Netupitant.Approved, Investigational
IfosfamideThe serum concentration of Ifosfamide can be increased when it is combined with Netupitant.Approved
IloperidoneThe serum concentration of Iloperidone can be increased when it is combined with Netupitant.Approved
ImatinibThe serum concentration of Imatinib can be increased when it is combined with Netupitant.Approved
ImidafenacinThe serum concentration of Imidafenacin can be increased when it is combined with Netupitant.Approved, Investigational
ImipramineThe serum concentration of Imipramine can be increased when it is combined with Netupitant.Approved
ImiquimodThe serum concentration of Imiquimod can be increased when it is combined with Netupitant.Approved, Investigational
IndacaterolThe serum concentration of Indacaterol can be increased when it is combined with Netupitant.Approved
IndapamideThe serum concentration of Indapamide can be increased when it is combined with Netupitant.Approved
IndinavirThe serum concentration of Indinavir can be increased when it is combined with Netupitant.Approved
Ipratropium bromideThe serum concentration of Ipratropium bromide can be increased when it is combined with Netupitant.Approved
IrbesartanThe metabolism of Netupitant can be decreased when combined with Irbesartan.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Netupitant.Approved, Investigational
IsavuconazoniumThe serum concentration of Isavuconazonium can be increased when it is combined with Netupitant.Approved, Investigational
IsoniazidThe metabolism of Netupitant can be decreased when combined with Isoniazid.Approved
Isosorbide DinitrateThe serum concentration of Isosorbide Dinitrate can be increased when it is combined with Netupitant.Approved
Isosorbide MononitrateThe serum concentration of Isosorbide Mononitrate can be increased when it is combined with Netupitant.Approved
IsradipineThe serum concentration of Isradipine can be increased when it is combined with Netupitant.Approved
ItraconazoleThe serum concentration of Itraconazole can be increased when it is combined with Netupitant.Approved, Investigational
IvacaftorThe serum concentration of Ivacaftor can be increased when it is combined with Netupitant.Approved
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Netupitant.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be increased when it is combined with Netupitant.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be increased when it is combined with Netupitant.Approved
KetamineThe serum concentration of Ketamine can be increased when it is combined with Netupitant.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Netupitant.Approved
KetobemidoneThe serum concentration of Ketobemidone can be increased when it is combined with Netupitant.Approved, Investigational
KetoconazoleThe serum concentration of Ketoconazole can be increased when it is combined with Netupitant.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Netupitant.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be increased when it is combined with Netupitant.Approved, Investigational
LaquinimodThe serum concentration of Laquinimod can be increased when it is combined with Netupitant.Investigational
LeflunomideThe metabolism of Netupitant can be decreased when combined with Leflunomide.Approved, Investigational
LenvatinibThe serum concentration of Lenvatinib can be increased when it is combined with Netupitant.Approved
LercanidipineThe serum concentration of Lercanidipine can be increased when it is combined with Netupitant.Approved, Investigational
LetrozoleThe serum concentration of Letrozole can be increased when it is combined with Netupitant.Approved, Investigational
LevobupivacaineThe serum concentration of Levobupivacaine can be increased when it is combined with Netupitant.Approved, Investigational
LevocetirizineThe serum concentration of Levocetirizine can be increased when it is combined with Netupitant.Approved
Levomethadyl AcetateThe serum concentration of Levomethadyl Acetate can be increased when it is combined with Netupitant.Approved, Investigational
LevomilnacipranThe serum concentration of Levomilnacipran can be increased when it is combined with Netupitant.Approved
LevonorgestrelThe serum concentration of Levonorgestrel can be increased when it is combined with Netupitant.Approved, Investigational
LevothyroxineThe serum concentration of Levothyroxine can be increased when it is combined with Netupitant.Approved
LidocaineThe serum concentration of Lidocaine can be increased when it is combined with Netupitant.Approved, Vet Approved
LisurideThe serum concentration of Lisuride can be increased when it is combined with Netupitant.Approved, Investigational
LobeglitazoneThe metabolism of Netupitant can be decreased when combined with Lobeglitazone.Approved, Investigational
LoperamideThe serum concentration of Loperamide can be increased when it is combined with Netupitant.Approved
LopinavirThe serum concentration of Lopinavir can be increased when it is combined with Netupitant.Approved
LoratadineThe serum concentration of Loratadine can be increased when it is combined with Netupitant.Approved
LorcaserinThe serum concentration of Lorcaserin can be increased when it is combined with Netupitant.Approved
LosartanThe serum concentration of Losartan can be increased when it is combined with Netupitant.Approved
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Netupitant.Approved, Investigational
LumefantrineThe serum concentration of Lumefantrine can be increased when it is combined with Netupitant.Approved
LurasidoneThe serum concentration of Lurasidone can be increased when it is combined with Netupitant.Approved
Lysergic Acid DiethylamideThe risk or severity of adverse effects can be increased when Lysergic Acid Diethylamide is combined with Netupitant.Illicit, Investigational, Withdrawn
MacitentanThe serum concentration of Macitentan can be increased when it is combined with Netupitant.Approved
ManidipineThe metabolism of Netupitant can be decreased when combined with Manidipine.Approved, Investigational
MaravirocThe serum concentration of Maraviroc can be increased when it is combined with Netupitant.Approved, Investigational
MebendazoleThe serum concentration of Mebendazole can be increased when it is combined with Netupitant.Approved, Vet Approved
Medroxyprogesterone acetateThe serum concentration of Medroxyprogesterone acetate can be increased when it is combined with Netupitant.Approved, Investigational
MefloquineThe serum concentration of Mefloquine can be increased when it is combined with Netupitant.Approved
MeloxicamThe serum concentration of Meloxicam can be increased when it is combined with Netupitant.Approved, Vet Approved
MetergolineThe risk or severity of adverse effects can be increased when Metergoline is combined with Netupitant.Experimental
MethadoneThe serum concentration of Methadone can be increased when it is combined with Netupitant.Approved
MethaqualoneThe serum concentration of Methaqualone can be increased when it is combined with Netupitant.Illicit, Withdrawn
MethotrimeprazineThe metabolism of Netupitant can be decreased when combined with Methotrimeprazine.Approved
MethoxsalenThe serum concentration of Methoxsalen can be increased when it is combined with Netupitant.Approved
MethoxyfluraneThe serum concentration of Methoxyflurane can be increased when it is combined with Netupitant.Approved, Investigational, Vet Approved
Methyl salicylateThe serum concentration of Methyl salicylate can be increased when it is combined with Netupitant.Approved, Vet Approved
MethylergometrineThe risk or severity of adverse effects can be increased when Methylergometrine is combined with Netupitant.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Netupitant.Approved, Vet Approved
MethyltestosteroneThe serum concentration of Methyltestosterone can be increased when it is combined with Netupitant.Approved
MethysergideThe risk or severity of adverse effects can be increased when Methysergide is combined with Netupitant.Approved
MetoprololThe metabolism of Netupitant can be decreased when combined with Metoprolol.Approved, Investigational
MetronidazoleThe serum concentration of Metronidazole can be increased when it is combined with Netupitant.Approved
MevastatinThe serum concentration of Mevastatin can be increased when it is combined with Netupitant.Experimental
MexiletineThe serum concentration of Mexiletine can be increased when it is combined with Netupitant.Approved
MianserinThe serum concentration of Mianserin can be increased when it is combined with Netupitant.Approved, Investigational
MibefradilThe serum concentration of Mibefradil can be increased when it is combined with Netupitant.Investigational, Withdrawn
MiconazoleThe serum concentration of Miconazole can be increased when it is combined with Netupitant.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Midazolam can be increased when it is combined with Netupitant.Approved, Illicit
MidostaurinThe serum concentration of Midostaurin can be increased when it is combined with Netupitant.Approved
MifepristoneThe serum concentration of Netupitant can be increased when it is combined with Mifepristone.Approved, Investigational
MirabegronThe serum concentration of Mirabegron can be increased when it is combined with Netupitant.Approved
MirtazapineThe serum concentration of Mirtazapine can be increased when it is combined with Netupitant.Approved
MitotaneThe serum concentration of Netupitant can be decreased when it is combined with Mitotane.Approved
ModafinilThe serum concentration of Modafinil can be increased when it is combined with Netupitant.Approved, Investigational
MontelukastThe serum concentration of Montelukast can be increased when it is combined with Netupitant.Approved
MorphineThe serum concentration of Morphine can be increased when it is combined with Netupitant.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Netupitant.Approved, Investigational
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Netupitant.Approved, Vet Approved
NateglinideThe serum concentration of Nateglinide can be increased when it is combined with Netupitant.Approved, Investigational
NefazodoneThe serum concentration of Nefazodone can be increased when it is combined with Netupitant.Approved, Withdrawn
NelfinavirThe serum concentration of Nelfinavir can be increased when it is combined with Netupitant.Approved
NeratinibThe serum concentration of Neratinib can be increased when it is combined with Netupitant.Approved, Investigational
NevirapineThe serum concentration of Nevirapine can be increased when it is combined with Netupitant.Approved
NicardipineThe serum concentration of Nicardipine can be increased when it is combined with Netupitant.Approved
NicergolineThe risk or severity of adverse effects can be increased when Nicergoline is combined with Netupitant.Approved, Investigational
NicotineThe serum concentration of Nicotine can be increased when it is combined with Netupitant.Approved
NifedipineThe serum concentration of Nifedipine can be increased when it is combined with Netupitant.Approved
NilotinibThe serum concentration of Nilotinib can be increased when it is combined with Netupitant.Approved, Investigational
NilvadipineThe serum concentration of Nilvadipine can be increased when it is combined with Netupitant.Approved, Investigational
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Netupitant.Approved
NisoldipineThe serum concentration of Nisoldipine can be increased when it is combined with Netupitant.Approved
NitrazepamThe serum concentration of Nitrazepam can be increased when it is combined with Netupitant.Approved
NitrendipineThe serum concentration of Nitrendipine can be increased when it is combined with Netupitant.Approved, Investigational
NorethisteroneThe serum concentration of Norethisterone can be increased when it is combined with Netupitant.Approved
NorgestrelThe serum concentration of Norgestrel can be increased when it is combined with Netupitant.Approved
NortriptylineThe serum concentration of Nortriptyline can be increased when it is combined with Netupitant.Approved
OdanacatibThe serum concentration of Odanacatib can be increased when it is combined with Netupitant.Investigational
OlopatadineThe serum concentration of Olopatadine can be increased when it is combined with Netupitant.Approved
OmeprazoleThe serum concentration of Omeprazole can be increased when it is combined with Netupitant.Approved, Investigational, Vet Approved
OndansetronThe serum concentration of Ondansetron can be increased when it is combined with Netupitant.Approved
OrphenadrineThe serum concentration of Orphenadrine can be increased when it is combined with Netupitant.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Netupitant.Approved
OxazepamThe serum concentration of Oxazepam can be increased when it is combined with Netupitant.Approved
OxybutyninThe serum concentration of Oxybutynin can be increased when it is combined with Netupitant.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Netupitant is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe serum concentration of Oxymorphone can be increased when it is combined with Netupitant.Approved, Investigational, Vet Approved
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Netupitant.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be increased when it is combined with Netupitant.Approved
PalonosetronThe serum concentration of Palonosetron can be increased when it is combined with Netupitant.Approved, Investigational
PanobinostatThe serum concentration of Netupitant can be increased when it is combined with Panobinostat.Approved, Investigational
PantoprazoleThe serum concentration of Pantoprazole can be increased when it is combined with Netupitant.Approved
ParamethadioneThe serum concentration of Paramethadione can be increased when it is combined with Netupitant.Approved
ParamethasoneThe serum concentration of Paramethasone can be increased when it is combined with Netupitant.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Netupitant.Approved
ParicalcitolThe serum concentration of Paricalcitol can be increased when it is combined with Netupitant.Approved, Investigational
ParitaprevirThe serum concentration of Paritaprevir can be increased when it is combined with Netupitant.Approved
ParoxetineThe metabolism of Netupitant can be decreased when combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Netupitant.Approved
Peginterferon alfa-2bThe serum concentration of Netupitant can be decreased when it is combined with Peginterferon alfa-2b.Approved
PentamidineThe serum concentration of Pentamidine can be increased when it is combined with Netupitant.Approved
PentobarbitalThe serum concentration of Netupitant can be decreased when it is combined with Pentobarbital.Approved, Vet Approved
PerampanelThe serum concentration of Perampanel can be increased when it is combined with Netupitant.Approved
PergolideThe serum concentration of Pergolide can be increased when it is combined with Netupitant.Approved, Investigational, Vet Approved, Withdrawn
PerhexilineThe serum concentration of Perhexiline can be increased when it is combined with Netupitant.Approved, Investigational
PermethrinThe serum concentration of Permethrin can be increased when it is combined with Netupitant.Approved, Investigational
PerospironeThe serum concentration of Perospirone can be increased when it is combined with Netupitant.Approved
PerphenazineThe serum concentration of Perphenazine can be increased when it is combined with Netupitant.Approved
PethidineThe serum concentration of Pethidine can be increased when it is combined with Netupitant.Approved
PhenacetinThe serum concentration of Phenacetin can be increased when it is combined with Netupitant.Withdrawn
PhenobarbitalThe serum concentration of Netupitant can be decreased when it is combined with Phenobarbital.Approved
PhenoxybenzamineThe serum concentration of Phenoxybenzamine can be increased when it is combined with Netupitant.Approved
PhenprocoumonThe serum concentration of Phenprocoumon can be increased when it is combined with Netupitant.Approved, Investigational
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Netupitant.Approved, Vet Approved
PilocarpineThe serum concentration of Pilocarpine can be increased when it is combined with Netupitant.Approved
PimecrolimusThe serum concentration of Pimecrolimus can be increased when it is combined with Netupitant.Approved, Investigational
PinacidilThe serum concentration of Pinacidil can be increased when it is combined with Netupitant.Withdrawn
PioglitazoneThe serum concentration of Pioglitazone can be increased when it is combined with Netupitant.Approved, Investigational
PipotiazineThe serum concentration of Pipotiazine can be increased when it is combined with Netupitant.Approved, Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Netupitant.Approved
PodofiloxThe serum concentration of Podofilox can be increased when it is combined with Netupitant.Approved
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Netupitant.Approved
PonatinibThe serum concentration of Ponatinib can be increased when it is combined with Netupitant.Approved
PosaconazoleThe serum concentration of Posaconazole can be increased when it is combined with Netupitant.Approved, Investigational, Vet Approved
PrasteroneThe serum concentration of Prasterone can be increased when it is combined with Netupitant.Approved, Nutraceutical
PrasugrelThe serum concentration of Prasugrel can be increased when it is combined with Netupitant.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Netupitant.Approved
PrazepamThe serum concentration of Prazepam can be increased when it is combined with Netupitant.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be increased when it is combined with Netupitant.Approved, Vet Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Netupitant.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Netupitant.Approved, Vet Approved
PrimaquineThe serum concentration of Primaquine can be increased when it is combined with Netupitant.Approved
PrimidoneThe serum concentration of Netupitant can be decreased when it is combined with Primidone.Approved, Vet Approved
ProchlorperazineThe serum concentration of Prochlorperazine can be increased when it is combined with Netupitant.Approved, Vet Approved
ProgesteroneThe serum concentration of Progesterone can be increased when it is combined with Netupitant.Approved, Vet Approved
ProguanilThe serum concentration of Proguanil can be increased when it is combined with Netupitant.Approved
PromazineThe serum concentration of Promazine can be increased when it is combined with Netupitant.Approved, Vet Approved
PropafenoneThe serum concentration of Propafenone can be increased when it is combined with Netupitant.Approved
PropofolThe serum concentration of Propofol can be increased when it is combined with Netupitant.Approved, Investigational, Vet Approved
Propoxyphene napsylateThe serum concentration of Propoxyphene napsylate can be increased when it is combined with Netupitant.Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Netupitant.Approved, Investigational
PyrazinamideThe serum concentration of Pyrazinamide can be increased when it is combined with Netupitant.Approved
PyrimethamineThe metabolism of Netupitant can be decreased when combined with Pyrimethamine.Approved, Vet Approved
QuazepamThe serum concentration of Quazepam can be increased when it is combined with Netupitant.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be increased when it is combined with Netupitant.Approved
QuinacrineThe serum concentration of Quinacrine can be increased when it is combined with Netupitant.Approved, Investigational
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Netupitant.Approved
QuinineThe serum concentration of Quinine can be increased when it is combined with Netupitant.Approved
RabeprazoleThe serum concentration of Rabeprazole can be increased when it is combined with Netupitant.Approved, Investigational
RaloxifeneThe serum concentration of Raloxifene can be increased when it is combined with Netupitant.Approved, Investigational
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Netupitant.Approved, Investigational
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Netupitant.Approved, Investigational
ReboxetineThe serum concentration of Reboxetine can be increased when it is combined with Netupitant.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be increased when it is combined with Netupitant.Approved
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Netupitant.Approved, Investigational
RetapamulinThe serum concentration of Retapamulin can be increased when it is combined with Netupitant.Approved
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Netupitant.Approved
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Netupitant.Approved
RifapentineThe serum concentration of Netupitant can be decreased when it is combined with Rifapentine.Approved
RilpivirineThe serum concentration of Rilpivirine can be increased when it is combined with Netupitant.Approved
RimonabantThe serum concentration of Rimonabant can be increased when it is combined with Netupitant.Approved, Investigational
RiociguatThe serum concentration of Riociguat can be increased when it is combined with Netupitant.Approved
RisperidoneThe serum concentration of Risperidone can be increased when it is combined with Netupitant.Approved, Investigational
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Netupitant.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Netupitant.Approved
RofecoxibThe serum concentration of Rofecoxib can be increased when it is combined with Netupitant.Investigational, Withdrawn
RolapitantThe serum concentration of Rolapitant can be increased when it is combined with Netupitant.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Netupitant.Approved, Investigational
RopiniroleThe serum concentration of Ropinirole can be increased when it is combined with Netupitant.Approved, Investigational
RopivacaineThe serum concentration of Ropivacaine can be increased when it is combined with Netupitant.Approved
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Netupitant.Approved
RotigotineThe serum concentration of Rotigotine can be increased when it is combined with Netupitant.Approved
RoxithromycinThe serum concentration of Roxithromycin can be increased when it is combined with Netupitant.Approved, Investigational, Withdrawn
RucaparibThe serum concentration of Rucaparib can be increased when it is combined with Netupitant.Approved, Investigational
RupatadineThe serum concentration of Rupatadine can be increased when it is combined with Netupitant.Approved
RuxolitinibThe serum concentration of Ruxolitinib can be increased when it is combined with Netupitant.Approved
SafinamideThe serum concentration of Safinamide can be increased when it is combined with Netupitant.Approved
SalmeterolThe serum concentration of Salmeterol can be increased when it is combined with Netupitant.Approved
SaquinavirThe serum concentration of Saquinavir can be increased when it is combined with Netupitant.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be increased when it is combined with Netupitant.Approved
SecobarbitalThe metabolism of Netupitant can be increased when combined with Secobarbital.Approved, Vet Approved
SelegilineThe serum concentration of Selegiline can be increased when it is combined with Netupitant.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Netupitant.Approved
SeratrodastThe serum concentration of Seratrodast can be increased when it is combined with Netupitant.Approved
SertindoleThe serum concentration of Sertindole can be increased when it is combined with Netupitant.Approved, Investigational, Withdrawn
SertralineThe serum concentration of Sertraline can be increased when it is combined with Netupitant.Approved
SevofluraneThe serum concentration of Sevoflurane can be increased when it is combined with Netupitant.Approved, Vet Approved
SibutramineThe serum concentration of Sibutramine can be increased when it is combined with Netupitant.Approved, Illicit, Investigational, Withdrawn
SildenafilThe serum concentration of Sildenafil can be increased when it is combined with Netupitant.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Netupitant.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Netupitant.Approved
SirolimusThe serum concentration of Sirolimus can be increased when it is combined with Netupitant.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Netupitant.Approved, Investigational
SolifenacinThe serum concentration of Solifenacin can be increased when it is combined with Netupitant.Approved
SonidegibThe serum concentration of Sonidegib can be increased when it is combined with Netupitant.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be increased when it is combined with Netupitant.Approved, Investigational
SpiramycinThe serum concentration of Spiramycin can be increased when it is combined with Netupitant.Approved
St. John's WortThe serum concentration of Netupitant can be decreased when it is combined with St. John's Wort.Investigational, Nutraceutical
StiripentolThe metabolism of Netupitant can be decreased when combined with Stiripentol.Approved
SufentanilThe serum concentration of Sufentanil can be increased when it is combined with Netupitant.Approved, Investigational
SulfadiazineThe serum concentration of Sulfadiazine can be increased when it is combined with Netupitant.Approved, Vet Approved
SulfamethoxazoleThe serum concentration of Sulfamethoxazole can be increased when it is combined with Netupitant.Approved
SulfinpyrazoneThe serum concentration of Sulfinpyrazone can be increased when it is combined with Netupitant.Approved
SulfisoxazoleThe metabolism of Netupitant can be decreased when combined with Sulfisoxazole.Approved, Vet Approved
SunitinibThe serum concentration of Sunitinib can be increased when it is combined with Netupitant.Approved, Investigational
SuvorexantThe serum concentration of Suvorexant can be increased when it is combined with Netupitant.Approved
Synthetic Conjugated Estrogens, AThe serum concentration of Synthetic Conjugated Estrogens, A can be increased when it is combined with Netupitant.Approved
Synthetic Conjugated Estrogens, BThe serum concentration of Synthetic Conjugated Estrogens, B can be increased when it is combined with Netupitant.Approved
TacrolimusThe serum concentration of Tacrolimus can be increased when it is combined with Netupitant.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be increased when it is combined with Netupitant.Approved, Investigational
TamoxifenThe serum concentration of Tamoxifen can be increased when it is combined with Netupitant.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Netupitant.Approved, Investigational
TasosartanThe serum concentration of Tasosartan can be increased when it is combined with Netupitant.Approved
Taurochenodeoxycholic acidThe serum concentration of Taurochenodeoxycholic acid can be increased when it is combined with Netupitant.Experimental
TelaprevirThe serum concentration of Telaprevir can be increased when it is combined with Netupitant.Approved, Withdrawn
TelithromycinThe serum concentration of Telithromycin can be increased when it is combined with Netupitant.Approved
TemazepamThe serum concentration of Temazepam can be increased when it is combined with Netupitant.Approved
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Netupitant.Approved
TeniposideThe serum concentration of Teniposide can be increased when it is combined with Netupitant.Approved
TerbinafineThe serum concentration of Terbinafine can be increased when it is combined with Netupitant.Approved, Investigational, Vet Approved
TerfenadineThe serum concentration of Terfenadine can be increased when it is combined with Netupitant.Withdrawn
TergurideThe risk or severity of adverse effects can be increased when Terguride is combined with Netupitant.Experimental
TesmilifeneThe serum concentration of Tesmilifene can be increased when it is combined with Netupitant.Investigational
TestosteroneThe serum concentration of Testosterone can be increased when it is combined with Netupitant.Approved, Investigational
TetracyclineThe serum concentration of Tetracycline can be increased when it is combined with Netupitant.Approved, Vet Approved
TheophyllineThe serum concentration of Theophylline can be increased when it is combined with Netupitant.Approved
ThioridazineThe metabolism of Netupitant can be decreased when combined with Thioridazine.Approved, Withdrawn
ThiotepaThe serum concentration of Thiotepa can be increased when it is combined with Netupitant.Approved
TiagabineThe serum concentration of Tiagabine can be increased when it is combined with Netupitant.Approved
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Netupitant.Approved
TiclopidineThe serum concentration of Ticlopidine can be increased when it is combined with Netupitant.Approved
TinidazoleThe serum concentration of Tinidazole can be increased when it is combined with Netupitant.Approved, Investigational
TiotropiumThe serum concentration of Tiotropium can be increased when it is combined with Netupitant.Approved
TipranavirThe serum concentration of Tipranavir can be increased when it is combined with Netupitant.Approved, Investigational
TofacitinibThe serum concentration of Tofacitinib can be increased when it is combined with Netupitant.Approved, Investigational
TolbutamideThe metabolism of Netupitant can be decreased when combined with Tolbutamide.Approved
TolterodineThe serum concentration of Tolterodine can be increased when it is combined with Netupitant.Approved, Investigational
TopiroxostatThe metabolism of Netupitant can be decreased when combined with Topiroxostat.Approved, Investigational
ToremifeneThe serum concentration of Toremifene can be increased when it is combined with Netupitant.Approved, Investigational
TramadolThe serum concentration of Tramadol can be increased when it is combined with Netupitant.Approved, Investigational
TranylcypromineThe metabolism of Netupitant can be decreased when combined with Tranylcypromine.Approved
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Netupitant.Approved
TrazodoneThe serum concentration of Trazodone can be increased when it is combined with Netupitant.Approved, Investigational
TretinoinThe serum concentration of Tretinoin can be increased when it is combined with Netupitant.Approved, Investigational, Nutraceutical
TriamcinoloneThe serum concentration of Triamcinolone can be increased when it is combined with Netupitant.Approved, Vet Approved
TriazolamThe serum concentration of Triazolam can be increased when it is combined with Netupitant.Approved
TrimethadioneThe serum concentration of Trimethadione can be increased when it is combined with Netupitant.Approved
TrimethoprimThe serum concentration of Trimethoprim can be increased when it is combined with Netupitant.Approved, Vet Approved
TrimipramineThe serum concentration of Trimipramine can be increased when it is combined with Netupitant.Approved
TroglitazoneThe serum concentration of Troglitazone can be increased when it is combined with Netupitant.Investigational, Withdrawn
TroleandomycinThe serum concentration of Troleandomycin can be increased when it is combined with Netupitant.Approved
UbidecarenoneThe serum concentration of Ubidecarenone can be increased when it is combined with Netupitant.Approved, Experimental
UdenafilThe serum concentration of Udenafil can be increased when it is combined with Netupitant.Approved, Investigational
ValbenazineThe serum concentration of Valbenazine can be increased when it is combined with Netupitant.Approved, Investigational
ValdecoxibThe serum concentration of Valdecoxib can be increased when it is combined with Netupitant.Investigational, Withdrawn
Valproic AcidThe metabolism of Netupitant can be decreased when combined with Valproic Acid.Approved, Investigational
ValsartanThe metabolism of Netupitant can be decreased when combined with Valsartan.Approved, Investigational
VandetanibThe serum concentration of Vandetanib can be increased when it is combined with Netupitant.Approved
VanoxerineThe serum concentration of Vanoxerine can be increased when it is combined with Netupitant.Investigational
VardenafilThe serum concentration of Vardenafil can be increased when it is combined with Netupitant.Approved
VelpatasvirThe serum concentration of Velpatasvir can be increased when it is combined with Netupitant.Approved
VemurafenibThe serum concentration of Vemurafenib can be increased when it is combined with Netupitant.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Netupitant.Approved
VenlafaxineThe serum concentration of Venlafaxine can be increased when it is combined with Netupitant.Approved
VerapamilThe serum concentration of Verapamil can be increased when it is combined with Netupitant.Approved
VicrivirocThe serum concentration of Vicriviroc can be increased when it is combined with Netupitant.Investigational
VilanterolThe serum concentration of Vilanterol can be increased when it is combined with Netupitant.Approved
VilazodoneThe serum concentration of Vilazodone can be increased when it is combined with Netupitant.Approved
VinblastineThe serum concentration of Vinblastine can be increased when it is combined with Netupitant.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Netupitant.Approved, Investigational
VindesineThe serum concentration of Vindesine can be increased when it is combined with Netupitant.Approved, Investigational
VinorelbineThe serum concentration of Vinorelbine can be increased when it is combined with Netupitant.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Netupitant.Approved
VoriconazoleThe serum concentration of Voriconazole can be increased when it is combined with Netupitant.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Netupitant.Approved
VoxilaprevirThe serum concentration of Voxilaprevir can be increased when it is combined with Netupitant.Approved
WarfarinThe serum concentration of Warfarin can be increased when it is combined with Netupitant.Approved
YohimbineThe serum concentration of Yohimbine can be increased when it is combined with Netupitant.Approved, Vet Approved
ZafirlukastThe serum concentration of Zafirlukast can be increased when it is combined with Netupitant.Approved, Investigational
ZalcitabineThe serum concentration of Zalcitabine can be increased when it is combined with Netupitant.Approved, Investigational
ZaleplonThe serum concentration of Zaleplon can be increased when it is combined with Netupitant.Approved, Illicit, Investigational
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Netupitant.Approved
ZileutonThe serum concentration of Zileuton can be increased when it is combined with Netupitant.Approved, Investigational, Withdrawn
ZiprasidoneThe serum concentration of Ziprasidone can be increased when it is combined with Netupitant.Approved
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Netupitant.Approved
ZomepiracThe serum concentration of Zomepirac can be increased when it is combined with Netupitant.Withdrawn
ZonisamideThe serum concentration of Zonisamide can be increased when it is combined with Netupitant.Approved, Investigational
ZopicloneThe serum concentration of Zopiclone can be increased when it is combined with Netupitant.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be increased when it is combined with Netupitant.Approved, Investigational
Food Interactions
Not Available

References

General References
  1. Darmani NA, Zhong W, Chebolu S, Mercadante F: Differential and additive suppressive effects of 5-HT3 (palonosetron)- and NK1 (netupitant)-receptor antagonists on cisplatin-induced vomiting and ERK1/2, PKA and PKC activation. Pharmacol Biochem Behav. 2015 Apr;131:104-11. doi: 10.1016/j.pbb.2015.02.010. Epub 2015 Feb 14. [PubMed:25687374]
External Links
KEGG Drug
D10572
PubChem Compound
6451149
PubChem Substance
310264992
ChemSpider
4953629
BindingDB
50178574
ChEBI
85155
ChEMBL
CHEMBL206253
Wikipedia
Netupitant
FDA label
Download (273 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2Not Yet RecruitingSupportive CareChemotherapy Induced Nausea Vomiting1
2RecruitingPreventionProphylaxis of acute chemotherapy induced nausea and vomiting1
2RecruitingSupportive CareHematopoietic Cell Transplantation Recipient / Hematopoietic Stem Cell Transplantation (HSCT) / Nausea / Neoplasms, Malignant / Vomiting1
2, 3RecruitingSupportive CareIn Situ Neoplasm / Nausea and Vomiting, Chronic / Neoplasms, Malignant1
3CompletedPreventionProphylaxis of acute chemotherapy induced nausea and vomiting3

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
CapsuleOral
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US9186357No2010-11-182030-11-18Us
US8623826No2010-11-182030-11-18Us
US8951969No2010-11-182030-11-18Us
US6297375No2000-02-222020-02-22Us
US9271975No2011-09-092031-09-09Us

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00285 mg/mLALOGPS
logP5.48ALOGPS
logP7.26ChemAxon
logS-5.3ALOGPS
pKa (Strongest Basic)7.6ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area39.68 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity148.59 m3·mol-1ChemAxon
Polarizability55.88 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as pyridinylpiperazines. These are compounds containing a pyridinylpiperazine skeleton, which consists of a pyridine linked (not fused) to a piperazine by a bond by a single bond that is not part of a ring.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Diazinanes
Sub Class
Piperazines
Direct Parent
Pyridinylpiperazines
Alternative Parents
N-arylpiperazines / Phenylpyridines / Trifluoromethylbenzenes / Phenylacetamides / Phenylpropanes / Dialkylarylamines / Toluenes / N-methylpiperazines / Aminopyridines and derivatives / Imidolactams
show 11 more
Substituents
N-arylpiperazine / 4-phenylpyridine / Pyridinylpiperazine / Phenylacetamide / Trifluoromethylbenzene / Phenylpropane / Dialkylarylamine / Toluene / N-alkylpiperazine / N-methylpiperazine
show 27 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
organofluorine compound, N-arylpiperazine, monocarboxylic acid amide, ring assembly, N-alkylpiperazine, toluenes, aminopyridine (CHEBI:85155)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Antagonist
General Function
Tachykinin receptor activity
Specific Function
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of aff...
Gene Name
TACR1
Uniprot ID
P25103
Uniprot Name
Substance-P receptor
Molecular Weight
46250.5 Da
References
  1. Darmani NA, Zhong W, Chebolu S, Mercadante F: Differential and additive suppressive effects of 5-HT3 (palonosetron)- and NK1 (netupitant)-receptor antagonists on cisplatin-induced vomiting and ERK1/2, PKA and PKC activation. Pharmacol Biochem Behav. 2015 Apr;131:104-11. doi: 10.1016/j.pbb.2015.02.010. Epub 2015 Feb 14. [PubMed:25687374]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Substrate
General Function
Monooxygenase activity
Specific Function
Exhibits low testosterone 6-beta-hydroxylase activity.
Gene Name
CYP3A43
Uniprot ID
Q9HB55
Uniprot Name
Cytochrome P450 3A43
Molecular Weight
57669.21 Da
References
  1. Calcagnile S, Lanzarotti C, Rossi G, Henriksson A, Kammerer KP, Timmer W: Effect of netupitant, a highly selective NK(1) receptor antagonist, on the pharmacokinetics of palonosetron and impact of the fixed dose combination of netupitant and palonosetron when coadministered with ketoconazole, rifampicin, and oral contraceptives. Support Care Cancer. 2013 Oct;21(10):2879-87. doi: 10.1007/s00520-013-1857-9. Epub 2013 Jun 11. [PubMed:23748441]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. Calcagnile S, Lanzarotti C, Rossi G, Henriksson A, Kammerer KP, Timmer W: Effect of netupitant, a highly selective NK(1) receptor antagonist, on the pharmacokinetics of palonosetron and impact of the fixed dose combination of netupitant and palonosetron when coadministered with ketoconazole, rifampicin, and oral contraceptives. Support Care Cancer. 2013 Oct;21(10):2879-87. doi: 10.1007/s00520-013-1857-9. Epub 2013 Jun 11. [PubMed:23748441]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. Calcagnile S, Lanzarotti C, Rossi G, Henriksson A, Kammerer KP, Timmer W: Effect of netupitant, a highly selective NK(1) receptor antagonist, on the pharmacokinetics of palonosetron and impact of the fixed dose combination of netupitant and palonosetron when coadministered with ketoconazole, rifampicin, and oral contraceptives. Support Care Cancer. 2013 Oct;21(10):2879-87. doi: 10.1007/s00520-013-1857-9. Epub 2013 Jun 11. [PubMed:23748441]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da

Drug created on May 04, 2015 10:50 / Updated on November 09, 2017 04:44