Xenon-133

Identification

Name
Xenon-133
Accession Number
DB09315
Type
Small Molecule
Groups
Approved
Description

Xenon-133 is an isotope of xenon. It is a radionuclide that is inhaled to assess pulmonary function, and to image the lungs. It is also used to image blood flow, particularly in the brain.

Structure
Thumb
Synonyms
  • Xenon (133 xe)
  • Xenon (133Xe) gas
  • Xenon Xe 133
  • Xenon XE-133
  • Xenon, Xe-133
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
XenonGas20 mCi/1Respiratory (inhalation)Lantheus Medical Imaging1974-10-10Not applicableUs
XenonGas10 mCi/1Respiratory (inhalation)Lantheus Medical Imaging1974-10-10Not applicableUs
Xenon, Xe-133Gas5 mCi/mLRespiratory (inhalation)Mallinckrodt2015-07-012017-07-01Us
Xenon, Xe-133Gas5 mCi/mLRespiratory (inhalation)Mallinckrodt Nuclear Medicine Llc2015-07-01Not applicableUs
Xenon, Xe-133Gas10 mCi/mLRespiratory (inhalation)Mallinckrodt2015-07-012017-07-01Us
Xenon, Xe-133Gas10 mCi/mLRespiratory (inhalation)Mallinckrodt Nuclear Medicine Llc2015-07-01Not applicableUs
Categories
UNII
X3P9A5HNYF
CAS number
14932-42-4
Weight
Average: 132.9059
Monoisotopic: 132.90590566
Chemical Formula
Xe
InChI Key
FHNFHKCVQCLJFQ-NJFSPNSNSA-N
InChI
InChI=1S/Xe/i1+2
IUPAC Name
(¹³³Xe)xenon
SMILES
[133Xe]

Pharmacology

Indication

Inhalation of Xenon Xe 133 Gas has proved valuable for the evaluation of pulmonary function and for imaging the lungs. It may also be applied to assessment of cerebral flow.

Structured Indications
Not Available
Pharmacodynamics

Xenon Xe 133 is a readily diffusible gas which is neither utilized nor produced by the body. It passes through cell membranes and freely exchanges between blood and tissue. It tends to concentrate more in body fat than in blood, plasma, water or protein solutions.

Mechanism of action

Xenon-133 is used for the diagnostic evaluation of pulmonary function and imaging, as well as assessment of cerebral blood flow. In the concentrations used for diagnostic purposes it is physiologically inactive.

Absorption

Inhaled Xenon Xe 133 Gas will enter the alveolar wall and enter the pulmonary venous circulation via the capillaries.

Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination

Most of the Xenon Xe 133 that enters the circulation from a single breath is returned to the lungs and exhaled after a single pass through the peripheral circulation.

Half life

Half Life 5.245 days

Clearance
Not Available
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. FDA label [Link]
External Links
PubChem Compound
66376
PubChem Substance
310265200
ChemSpider
59751
ChEMBL
CHEMBL1200685
ATC Codes
V09EX03 — Xenon (133xe) gas

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentSympathetic Nervous System1
1RecruitingBasic ScienceBMI >30 kg/m21
1RecruitingDiagnosticAsthma Bronchial / Chronic Obstructive Pulmonary Disease (COPD) / Cystic Fibrosis (CF) / Interstitial Lung Disease (ILD) / Pulmonary Hypertension (PH)1
2CompletedSupportive CareColorectal Cancers1
2CompletedTreatmentAnaesthesia therapy / Coronary Artery Disease2
2CompletedTreatmentDelirium1
2CompletedTreatmentIschemic Brain Injury1
2RecruitingBasic ScienceNeurocognitive Dysfunction1
2WithdrawnTreatmentObsessive-Compulsive Disorder (OCD)1
3CompletedScreeningCoronary Arteries Disease Risk / Elevated Cardiac Risk1
3CompletedTreatmentAnesthetics, Inhalation / Coronary Artery Bypass Graft / Coronary Heart Disease (CHD) / Sevoflurane / Xenon1
3CompletedTreatmentCoronary Artery Bypass Graft Surgery / Coronary Artery Disease / General Anesthetic Drug Allergy1
3CompletedTreatmentRenal Function After Partial Nephrectomy1
3RecruitingOtherLung Structure Determination1
3TerminatedDiagnosticProphylaxis of Pulmonary embolism1
3TerminatedTreatmentAnaesthesia1
4CompletedOtherAnaesthesia therapy1
4CompletedTreatmentAnaesthetics Gases, Xenon / Anaesthetics Volatile, Sevoflurane / Depth of Anaesthesia / Prophylaxis against postoperative nausea and vomiting1
4CompletedTreatmentBMI >30 kg/m21
4CompletedTreatmentHemodynamic Stability1
Not AvailableActive Not RecruitingPreventionAortic Dissection1
Not AvailableCompletedNot AvailableAnaesthesia therapy1
Not AvailableRecruitingTreatmentAcute Lung Injury (ALI)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
GasRespiratory (inhalation)10 mCi/1
GasRespiratory (inhalation)20 mCi/1
GasRespiratory (inhalation)10 mCi/mL
GasRespiratory (inhalation)5 mCi/mL
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP0ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as homogeneous noble gases. These are inorganic non-metallic compounds in which the largest atom is a halogen atom.
Kingdom
Inorganic compounds
Super Class
Homogeneous non-metal compounds
Class
Homogeneous noble gases
Sub Class
Not Available
Direct Parent
Homogeneous noble gases
Alternative Parents
Not Available
Substituents
Homogeneous noble gas
Molecular Framework
Not Available
External Descriptors
Not Available

Drug created on November 16, 2015 16:06 / Updated on December 01, 2017 16:15