Chronic Obstructive Pulmonary Disease (COPD)

Also known as: Chronic Obstructive Lung Disease (COLD) / Chronic Obstructive Airway Disease / Chronic Obstructive Pulmonary Disease / Chronic Obstructive Pulmonary Disease, COPD / COPD(Chronic Obstructive Pulmonary Disease) / Pulmonary Disease, Chronic Obstructive (COPD) / Chronic Obstructive Lung Disease / Pulmonary Disease, Chronic Obstructive / Chronic Obstructive Pulmonary Disease: COPD / Chronic Obstructive Pulmonary Disease - COPD / Chronic Obstructive Lung Diseases / COPD, Chronic Obstructive Pulmonary Disease / Pulmonary Disease Chronic Obstructive / COPD - Chronic Obstructive Pulmonary Disease / Pulmonary Disease (COPD), Chronic Obstructive / COPD Chronic Obstructive Pulmonary Disease / COPD (Chronic Obstructive Pulmonary Disease) / Obstructive Chronic Pulmonary Disease / Chronic Obstructive Pulmonary Disease(COPD) / Chronic Obstructive Bronchopneumopathy / Chronic Obstructive Pulmonary Diseases / COPD / COAD / Chronic obstructive pulmonary disease finding / Hyperactive airway disease / Chronic airflow limitation / Chronic obstructive airway disease NOS / Obstructive airways disease (chronic) / Chronic obstructive airways disease / Chronic obstruct airways disease

DrugDrug NameDrug Description
DB08897AclidiniumAclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012.
DB01274ArformoterolArformoterol is a bronchodilator. It works by relaxing muscles in the airways to improve breathing. Arformoterol inhalation is used to prevent bronchoconstriction in people with chronic obstructive pulmonary disease, including chronic bronchitis and emphysema. The use of arformoterol is pending revision due to safety concerns in regards to an increased risk of severe exacerbation of asthma symptoms, leading to hospitalization as well as death in some patients using long acting beta agonists for the treatment of asthma.
DB00394Beclomethasone dipropionateBeclomethasone dipropionate is a prodrug of the free form, beclomethasone (beclomethasone-17-monopropionate). An anti-inflammatory, synthetic corticosteroid, it is used topically as an anti-inflammatory agent and in aerosol form for the treatment of asthma and allergic rhinitis (seasonal and perennial). Beclometasone dipropionate is also being investigated for oral treatment in mild-to-moderate Crohn's disease of ileal or ileal-right colonic localisation and for "topical" use mild-to-moderate graft versus host disease. It is marketed under several brand names such as Qnasl (US) and Rivanase AQ (Canada).
DB01222BudesonideBudesonide is a glucocorticoid used in the management of asthma, the treatment of various skin disorders, and allergic rhinitis. [PubChem] The extended release oral tablet, marketed as Uceris, was FDA approved on January 14, 2013 for the management of ulcerative colitis. Budesonide is provided as a mixture of two epimers (22R and 22S). Interestingly, the 22R form is two times more active than the 22S epimer. The two forms do not interconvert.
DB00561DoxapramA central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
DB08906Fluticasone furoateFluticasone furoate is a synthetic glucocorticoid available as an inhaler and nasal spray for various inflammatory indications[FDA Label][F4364]. Fluticasone furoate was first approved in 2007[L5965].
DB00588Fluticasone propionateFluticasone propionate is a synthetic glucocorticoid[F4355,F4358][FDA Label]. These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications[F4355,F4358][FDA Label]. Fluticasone propionate was first approved in 1990[L5962].
DB00983FormoterolFormoterol is a long-acting (12 hours) beta2-agonist used in the management of asthma and/or chronic obstructive pulmonary disease (COPD). Inhaled formoterol works like other beta2-agonists, causing bronchodilatation through relaxation of the smooth muscle in the airway so as to treat the exacerbation of asthma.
DB00986GlycopyrroniumGlycopyrronium (as the bromide salt glycopyrrolate) is a synthetic anticholinergic agent with a quaternary ammonium structure. A muscarinic competitive antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics. In October 2015, glycopyrrolate was approved by the FDA for use as a standalone treatment for Chronic obstructive pulmonary disease (COPD), as Seebri Neohaler.
DB05039IndacaterolIndacaterol is a novel, ultra-long-acting, rapid onset β(2)-adrenoceptor agonist developed for Novartis for the once-daily management of asthma and chronic obstructive pulmonary disease. It was approved by the European Medicines Agency (EMA) on 30 November 2009 and by the FDA on 1 July 2011. It is marketed in Europe as Onbrez and in America as Arcapta Neohaler. Indacaterol is provided as its maleate salt form. Indacaterol is also a chiral molecule but only the pure R-enantiomer is dispensed.
DB00332IpratropiumIpratropium is a quaternary ammonium derivative of [atropine][A176957] that acts as an anticholinergic agent.[A176939] It is commonly administered through inhalation which allows producing a local effect without presenting a significant systemic absorption.[A176957] Ipratropium as a therapeutic agent was developed by Boehringer Ingelheim and its first monotherapy product was FDA approved in 1986.[L5891] On the other hand, the combination product of ipratropium and [albuterol] was approved in 1996.[L5894]
DB13139LevosalbutamolLevosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective disposition of salbutamol and the possibility that (S)-salbutamol has adverse effects have led to the development of an enantiomerically pure (R)-salbutamol formulation known as levosalbutamol (levalbuterol).
DB09080OlodaterolOlodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, via a downstream L-type calcium channel interaction, mediates smooth muscle relaxation and bronchodilation. Activation of the receptor stimulates an associated G protein which then activates adenylate cyclase, catalyzing the formation of cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA). Elevation of these two molecules induces bronchodilation by relaxation of airway smooth muscles. It is by this mechanism that olodaterol is used for the treatment of chronic obstructive pulmonary disease (COPD) and the progressive airflow obstruction that is characteristic of it. Treatment with bronchodilators helps to mitigate associated symptoms such as shortness of breath, cough, and sputum production. Single doses of olodaterol have been shown to improve forced expiratory volume in 1 sec (FEV1) for 24 h in patients with COPD, allowing once daily dosing. A once-a-day treatment with a LABA has several advantages over short-acting bronchodilators and twice-daily LABAs including improved convenience and compliance and improved airflow over a 24-hour period. Despite similarities in symptoms, olodaterol is not indicated for the treatment of acute exacerbations of COPD or for the treatment of asthma.
DB01303OxtriphyllineOxtriphylline is the choline salt form of [theophylline]. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Its main physiological reponse is to dilate the bronchioles. As such, oxytriphylline is indicated mainly for asthma, bronchospasm, and COPD (i.e. all the same indications as the other theophyllines). It is marketed under the name Choledyl SA, and several forms of oxytriphylline have been discontinued. In the US, oxtriphylline is no longer available.
DB11855RevefenacinRevefenacin is a novel biphenyl carbamate tertiary amine agent that belongs to the family of the long-acting muscarinic antagonists (LABA). The labile primary amide in the structure produces a "soft-drug" site that allows rapid systemic clearance and minimizing of the systemically mediated adverse reactions. The LABA group falls into a parent category known as long-acting inhaled bronchodilators and this type of agents are recommended as a maintenance therapy for chronic obstructive pulmonary disease (COPD).[A40025] From the LABA group, revefenacin is the first once-daily nebulized LAMA treatment.[A40026] It was developed by Theravance Biopharma and FDA approved on November 9, 2018.[L4818]
DB01656RoflumilastRoflumilast is a phosphodiesterase-4 (PDE-4) inhibitor. Due to its selective inhibition of the PDE4 isoenzyme in lung cells, roflumilast is indicated for the management of chronic obstrtuctive pulmonary disease (COPD) exacerbations. Treatment with Roflumilast is associated with an increase in psychiatric adverse reactions, including suicide and suicidal attempts.
DB01001SalbutamolSalbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formulated as a racemic mixture of the R- and S-isomers. The R-isomer has 150 times greater affinity for the beta2-receptor than the S-isomer and the S-isomer has been associated with toxicity. This lead to the development of levalbuterol, the single R-isomer of salbutamol. However, the high cost of levalbuterol compared to salbutamol has deterred wide-spread use of this enantiomerically pure version of the drug. Salbutamol is generally used for acute episodes of bronchospasm caused by bronchial asthma, chronic bronchitis and other chronic bronchopulmonary disorders such as chronic obstructive pulmonary disorder (COPD). It is also used prophylactically for exercise-induced asthma. [FDA Label], [A174379, A174400]
DB00938SalmeterolSalmeterol is a long-acting beta2-adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.
DB00871TerbutalineA selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic. [PubChem]
DB01409TiotropiumTiotropium is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Tiotropium is a muscarinic receptor antagonist, on topical application it acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation, thus producing a bronchodilatory effect.
DB09076UmeclidiniumUmeclidinium is a long-acting muscarinic antagonist (LAMA) used as maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). It is available as a once-daily inhalation monotherapy or as a fixed-dose combination product with the long-acting beta2-agonist vilanterol. COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory volume in 1 second (FEV1) of less than 80%. By blocking the M3 muscarinic receptor which is highly expressed in airway smooth muscle of the lungs, umeclidinium inhibits the binding of acetylcholine and thereby opens up the airways by preventing bronchoconstriction. Its use has been shown to provide clinically significant, sustained improvements in lung function.
DB09082VilanterolVilanterol is a selective long-acting beta2-adrenergic agonist (LABA) with inherent 24-hour activity for once daily treatment of COPD and asthma. Its pharmacological effect is attributable to stimulation of intracellular adenylyl cyclase which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increases in cyclic AMP are associated with relaxation of bronchial smooth muscle and inhibition of release of hypersensitivity mediators from mast cells in the lungs. Vilanterol is approved for use in several combination products such as with fluticasone furoate under the tradename Breo Ellipta and in combination with umeclidinium bromide as Anoro Ellipta. Approved by the FDA in 2013, use of Breo Ellipta is indicated for the long-term, once-daily maintenance treatment of airflow obstruction in patients with COPD, including chronic bronchitis and emphysema. It is also indicated for once-daily maintenance treatment of asthma in patients aged 18 or older with reversible obstructive airways disease.
DrugDrug NameTargetType
DB08897AclidiniumMuscarinic acetylcholine receptor M1target
DB08897AclidiniumMuscarinic acetylcholine receptor M2target
DB08897AclidiniumMuscarinic acetylcholine receptor M3target
DB08897AclidiniumMuscarinic acetylcholine receptor M4target
DB08897AclidiniumMuscarinic acetylcholine receptor M5target
DB08897AclidiniumCholinesteraseenzyme
DB01274ArformoterolBeta-2 adrenergic receptortarget
DB01274ArformoterolCytochrome P450 2D6enzyme
DB01274ArformoterolCytochrome P450 2C19enzyme
DB01274ArformoterolCytochrome P450 2A6enzyme
DB01274ArformoterolCytochrome P450 2C9enzyme
DB00394Beclomethasone dipropionateCorticosteroid-binding globulincarrier
DB00394Beclomethasone dipropionateGlucocorticoid receptortarget
DB00394Beclomethasone dipropionateCytochrome P450 3A5enzyme
DB00394Beclomethasone dipropionateCytochrome P450 3A4enzyme
DB01222BudesonideGlucocorticoid receptortarget
DB01222BudesonideCytochrome P450 3A4enzyme
DB01222BudesonideCytochrome P450 3A5enzyme
DB01222BudesonideBile salt export pumptransporter
DB00561DoxapramPotassium channel subfamily K member 3target
DB00561DoxapramPotassium channel subfamily K member 9target
DB08906Fluticasone furoateCytochrome P450 3A4enzyme
DB08906Fluticasone furoateGlucocorticoid receptortarget
DB08906Fluticasone furoateMultidrug resistance protein 1transporter
DB08906Fluticasone furoateCytochrome P450 2C8enzyme
DB08906Fluticasone furoateSolute carrier organic anion transporter family member 1B1transporter
DB08906Fluticasone furoateCorticosteroid-binding globulincarrier
DB08906Fluticasone furoateMultidrug resistance protein 1carrier
DB08906Fluticasone furoateSolute carrier organic anion transporter family member 1B1carrier
DB08906Fluticasone furoateCytochrome P450 3A5enzyme
DB08906Fluticasone furoateCytochrome P450 3A7enzyme
DB08906Fluticasone furoateProgesterone receptortarget
DB08906Fluticasone furoateMineralocorticoid receptortarget
DB00588Fluticasone propionateCorticosteroid-binding globulincarrier
DB00588Fluticasone propionateCytosolic phospholipase A2target
DB00588Fluticasone propionateGlucocorticoid receptortarget
DB00588Fluticasone propionateCytochrome P450 3A4enzyme
DB00588Fluticasone propionateProgesterone receptortarget
DB00588Fluticasone propionateMineralocorticoid receptortarget
DB00588Fluticasone propionateCytochrome P450 3A5enzyme
DB00588Fluticasone propionateCytochrome P450 3A7enzyme
DB00588Fluticasone propionateCytochrome P450 2C8enzyme
DB00588Fluticasone propionateMultidrug resistance protein 1carrier
DB00588Fluticasone propionateSolute carrier organic anion transporter family member 1B1carrier
DB00983FormoterolBeta-2 adrenergic receptortarget
DB00983FormoterolCytochrome P450 2C19enzyme
DB00983FormoterolCytochrome P450 2C9enzyme
DB00983FormoterolCytochrome P450 2D6enzyme
DB00983FormoterolCytochrome P450 2A6enzyme
DB00983FormoterolBeta-1 adrenergic receptortarget
DB00983FormoterolBeta-3 adrenergic receptortarget
DB00986GlycopyrroniumMuscarinic acetylcholine receptor M1target
DB00986GlycopyrroniumMuscarinic acetylcholine receptor M3target
DB00986GlycopyrroniumMuscarinic acetylcholine receptor M2target
DB05039IndacaterolBeta-2 adrenergic receptortarget
DB05039IndacaterolCytochrome P450 3A4enzyme
DB05039IndacaterolUDP-glucuronosyltransferase 1-1enzyme
DB05039IndacaterolMultidrug resistance protein 1transporter
DB00332IpratropiumMuscarinic acetylcholine receptor M1target
DB00332IpratropiumMuscarinic acetylcholine receptor M2target
DB00332IpratropiumMuscarinic acetylcholine receptor M3target
DB00332IpratropiumSolute carrier family 22 member 5transporter
DB00332IpratropiumSolute carrier family 22 member 4transporter
DB00332IpratropiumSerum albumincarrier
DB00332Ipratropiumalpha1-acid glycoproteincarrier
DB13139LevosalbutamolBeta-2 adrenergic receptortarget
DB13139LevosalbutamolCytochrome P450 3A4enzyme
DB13139LevosalbutamolCytochrome P450 2D6enzyme
DB13139LevosalbutamolSolute carrier organic anion transporter family member 1B1transporter
DB13139LevosalbutamolSolute carrier organic anion transporter family member 1B3transporter
DB09080OlodaterolBeta-2 adrenergic receptortarget
DB09080OlodaterolCytochrome P450 2C9enzyme
DB09080OlodaterolCytochrome P450 2C8enzyme
DB01303OxtriphyllinecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB01303OxtriphyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB01303OxtriphyllineAdenosine receptor A2atarget
DB01303OxtriphyllineAdenosine receptor A1target
DB01303OxtriphyllineCytochrome P450 1A2enzyme
DB01303OxtriphyllineSolute carrier family 22 member 7transporter
DB01303OxtriphyllineHistone deacetylase 2target
DB11855RevefenacinCytochrome P450 2D6enzyme
DB11855RevefenacinMuscarinic acetylcholine receptortarget
DB11855RevefenacinSerum albumincarrier
DB11855RevefenacinSolute carrier organic anion transporter family member 1B1transporter
DB11855RevefenacinSolute carrier organic anion transporter family member 1B3transporter
DB11855RevefenacinMultidrug resistance protein 1transporter
DB11855RevefenacinATP-binding cassette sub-family G member 2transporter
DB01656RoflumilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
DB01656RoflumilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB01656RoflumilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB01656RoflumilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
DB01656RoflumilastCytochrome P450 3A4enzyme
DB01001SalbutamolBeta-2 adrenergic receptortarget
DB01001SalbutamolBeta-1 adrenergic receptortarget
DB01001SalbutamolCytochrome P450 3A4enzyme
DB01001SalbutamolBeta-3 adrenergic receptortarget
DB00938SalmeterolBeta-2 adrenergic receptortarget
DB00938SalmeterolCytochrome P450 3A4enzyme
DB00938SalmeterolCytochrome P450 2C8enzyme
DB00938SalmeterolCytochrome P450 3A5enzyme
DB00938SalmeterolCytochrome P450 3A7enzyme
DB00938SalmeterolBeta-1 adrenergic receptortarget
DB00938SalmeterolBeta-3 adrenergic receptortarget
DB00871TerbutalineBeta-2 adrenergic receptortarget
DB00871TerbutalineCholinesteraseenzyme
DB00871TerbutalineBeta-3 adrenergic receptortarget
DB00871TerbutalineBeta-1 adrenergic receptortarget
DB01409TiotropiumMuscarinic acetylcholine receptor M3target
DB01409TiotropiumCytochrome P450 2D6enzyme
DB01409TiotropiumCytochrome P450 3A4enzyme
DB01409TiotropiumMuscarinic acetylcholine receptor M1target
DB01409TiotropiumMuscarinic acetylcholine receptor M2target
DB01409TiotropiumSolute carrier family 22 member 5transporter
DB01409TiotropiumSolute carrier family 22 member 4transporter
DB01409TiotropiumMuscarinic acetylcholine receptor M4target
DB01409TiotropiumMuscarinic acetylcholine receptor M5target
DB09076UmeclidiniumMuscarinic acetylcholine receptor M1target
DB09076UmeclidiniumMuscarinic acetylcholine receptor M2target
DB09076UmeclidiniumMuscarinic acetylcholine receptor M3target
DB09076UmeclidiniumMuscarinic acetylcholine receptor M4target
DB09076UmeclidiniumMuscarinic acetylcholine receptor M5target
DB09076UmeclidiniumCytochrome P450 2D6enzyme
DB09076UmeclidiniumMultidrug resistance protein 1transporter
DB09082VilanterolCytochrome P450 3A4enzyme
DB09082VilanterolBeta-2 adrenergic receptortarget
DrugDrug NamePhaseStatusCount
DB00207Azithromycin0Completed1
DB00260Cycloserine0Recruiting1
DB00841Dobutamine0Terminated1
DB04335Inosine0Terminated1
DB08820Ivacaftor0Completed1
DB00331Metformin0Not Yet Recruiting1
DB00556Perflutren0Not Yet Recruiting1
DB06213Regadenoson0Terminated1
DB11104Sulfur hexafluoride0Not Yet Recruiting1
DB01409Tiotropium0Completed1
DB12100Abediterol1Completed1
DB08897Aclidinium1Not Yet Recruiting1
DB09278Activated charcoal1Completed1
DB11863Alvelestat1Completed2
DB00381Amlodipine1Completed2
DB12618Apocynin1Completed1
DB00126Ascorbic acid1Recruiting1
DB12054BQ-1231Recruiting1
DB00394Beclomethasone dipropionate1Completed2
DB05590Bedoradrine1Completed2
DB12023Benralizumab1Completed1
DB01222Budesonide1Completed3
DB12800CHF-60011Completed2
DB00091Ciclosporin1Completed1
DB00537Ciprofloxacin1Completed3
DB11922Danirixin1Completed4
DB12140Dilmapimod1Completed1
DB12135Elubrixin1Completed2
DB13900Equine Botulinum Neurotoxin A Immune FAB21Completed1
DB13903Equine Botulinum Neurotoxin B Immune FAB21Completed1
DB13898Equine Botulinum Neurotoxin C Immune FAB21Completed1
DB13902Equine Botulinum Neurotoxin D Immune FAB21Completed1
DB13897Equine Botulinum Neurotoxin E Immune FAB21Completed1
DB13901Equine Botulinum Neurotoxin F Immune FAB21Completed1
DB13899Equine Botulinum Neurotoxin G Immune FAB21Completed1
DB00950Fexofenadine1Recruiting1
DB00196Fluconazole1Completed1
DB08906Fluticasone furoate1Completed1
DB00588Fluticasone propionate1Completed7
DB00983Formoterol1Completed4
DB12296GS-57451Completed1
DB12137GSK-2560661Completed1
DB12091Gadolinium1Active Not Recruiting1
DB00986Glycopyrronium1Completed7
DB06583Glycopyrronium1Completed1
DB09526Hydroquinone1Completed1
DB05039Indacaterol1Completed2
DB04335Inosine1Active Not Recruiting1
DB00332Ipratropium1Completed2
DB01167Itraconazole1Completed1
DB01026Ketoconazole1Completed2
DB01137Levofloxacin1Completed1
DB12270Losmapimod1Completed2
DB14077Magnesium stearate1Completed1
DB00350Minoxidil1Completed1
DB05063Mitoquinone1Recruiting1
DB00218Moxifloxacin1Completed4
DB11711Navarixin1Terminated1
DB15031Nemorexant1Recruiting1
DB09080Olodaterol1Completed4
DB00338Omeprazole1Completed1
DB09140Oxygen1Completed1
DB12408PF-036356591Completed1
DB12138PF-037154551Completed1
DB11722PH-7978041Completed1
DB05392Perflubutane1Completed1
DB00692Phentolamine1Recruiting1
DB06809Plerixafor1Completed1
DB00860Prednisolone1Completed4
DB01366Procaterol1Completed1
DB00571Propranolol1Completed2
DB04216Quercetin1Completed1
DB00863Ranitidine1Recruiting1
DB11855Revefenacin1Completed2
DB08931Riociguat1Completed1
DB01656Roflumilast1Completed1
DB12186SRT-21041Completed1
DB01001Salbutamol1Completed2
DB00938Salmeterol1Completed7
DB00360Sapropterin1Recruiting1
DB00641Simvastatin1Completed1
DB00641Simvastatin1Unknown Status1
DB01409Tiotropium1Completed8
DB01409Tiotropium1Recruiting1
DB00374Treprostinil1Completed1
DB09076Umeclidinium1Completed7
DB06577Vilanterol1Completed7
DB09082Vilanterol1Completed5
DB09315Xenon-1331Recruiting1
DB06361rsPSMA Vaccine1Completed1
DB016325-O-phosphono-alpha-D-ribofuranosyl diphosphate1 / 2Recruiting1
DB06168Canakinumab1 / 2Completed1
DB00091Ciclosporin1 / 2Completed1
DB00983Formoterol1 / 2Completed1
DB11902Gisadenafil1 / 2Completed1
DB00986Glycopyrronium1 / 2Completed1
DB05039Indacaterol1 / 2Completed1
DB00742Mannitol1 / 2Withdrawn1
DB09140Oxygen1 / 2Withdrawn1
DB01656Roflumilast1 / 2Completed1
DB01409Tiotropium1 / 2Completed3
DB09076Umeclidinium1 / 2Completed1
DB09082Vilanterol1 / 2Completed1
DB05195ADC40222Completed1
DB13012AQX-11252Unknown Status1
DB11961AZD-12362Completed2
DB11946AZD-19812Completed1
DB12002AZD-48182Completed1
DB12280AZD-54232Completed1
DB12115AZD-91642Completed1
DB12100Abediterol2Completed1
DB00945Acetylsalicylic acid2Active Not Recruiting1
DB00945Acetylsalicylic acid2Completed1
DB00945Acetylsalicylic acid2Unknown Status1
DB08897Aclidinium2Completed6
DB11863Alvelestat2Completed4
DB06248Amelubant2Completed1
DB01274Arformoterol2Completed1
DB01076Atorvastatin2Completed1
DB00207Azithromycin2Terminated2
DB14886BIO-110062Completed1
DB12526Batefenterol2Completed1
DB08879Belimumab2Recruiting1
DB12023Benralizumab2Completed1
DB06197Bimosiamose2Completed2
DB00612Bisoprolol2Terminated1
DB00559Bosentan2Unknown Status1
DB01222Budesonide2Completed4
DB01222Budesonide2Recruiting1
DB12800CHF-60012Completed2
DB11588Carbon monoxide2Completed1
DB00878Chlorhexidine2Recruiting1
DB00169Cholecalciferol2Enrolling by Invitation1
DB01410Ciclesonide2Completed1
DB00537Ciprofloxacin2Completed1
DB00758Clopidogrel2Completed1
DB11922Danirixin2Completed2
DB11922Danirixin2Terminated2
DB12140Dilmapimod2Completed1
DB12192Emeramide2Completed1
DB00824Enprofylline2Recruiting1
DB05057Erdosteine2Completed1
DB08917Ferric carboxymaltose2Recruiting1
DB12011Fevipiprant2Not Yet Recruiting1
DB06640Fispemifene2Completed1
DB08906Fluticasone furoate2Recruiting1
DB00588Fluticasone propionate2Completed5
DB00588Fluticasone propionate2Recruiting1
DB00588Fluticasone propionate2Terminated1
DB00588Fluticasone propionate2Withdrawn1
DB00983Formoterol2Completed23
DB00983Formoterol2Recruiting1
DB00983Formoterol2Withdrawn1
DB12137GSK-2560662Completed1
DB05043GSK1597972Completed2
DB00986Glycopyrronium2Completed8
DB06583Glycopyrronium2Completed4
DB08818Hyaluronic acid2Unknown Status1
DB01088Iloprost2Completed1
DB01088Iloprost2Terminated1
DB00028Immune Globulin Human2Recruiting2
DB05039Indacaterol2Completed9
DB00065Infliximab2Completed1
DB00060Interferon beta-1a2Recruiting1
DB00332Ipratropium2Completed7
DB08820Ivacaftor2Recruiting1
DB11914Lebrikizumab2Completed1
DB01137Levofloxacin2Completed1
DB01137Levofloxacin2Recruiting2
DB12270Losmapimod2Completed5
DB00227Lovastatin2Completed1
DB13029MK-08732Terminated1
DB14009Medical Cannabis2Not Yet Recruiting1
DB00351Megestrol acetate2Completed1
DB11711Navarixin2Terminated2
DB12375Oglemilast2Completed1
DB09080Olodaterol2Completed4
DB00043Omalizumab2Withdrawn1
DB11871PF-006103552Completed2
DB12408PF-036356592Completed1
DB12138PF-037154552Terminated1
DB11722PH-7978042Completed3
DB05607PRX-080662Completed1
DB05607PRX-080662Terminated1
DB01708Prasterone2Unknown Status1
DB00980Ramelteon2Completed1
DB15256Reldesemtiv2Completed1
DB13973Remestemcel-L2Completed1
DB11855Revefenacin2Completed4
DB01656Roflumilast2Completed1
DB01656Roflumilast2Recruiting1
DB01656Roflumilast2Terminated2
DB01098Rosuvastatin2Completed1
DB01001Salbutamol2Completed4
DB00938Salmeterol2Completed14
DB00938Salmeterol2Withdrawn1
DB00360Sapropterin2Enrolling by Invitation1
DB00203Sildenafil2Completed1
DB09153Sodium chloride2Recruiting2
DB09153Sodium chloride2Terminated1
DB09308Solithromycin2Terminated1
DB00820Tadalafil2Active Not Recruiting1
DB00820Tadalafil2Completed1
DB08869Tesamorelin2Terminated1
DB05298Tetomilast2Completed1
DB12166Tetomilast2Completed1
DB12166Tetomilast2Terminated1
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