Sulfur

Identification

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Name
Octasulfur
Commonly known or available as Sulfur
Accession Number
DB09353
Type
Small Molecule
Groups
Approved
Description

Sulfur is a chemical element that is present in all living tissues. The most commonly used form of pharmaceutical sulfur is Octasulfur (S8). After calcium and phosphorus, it is the third most abundant mineral in the human body. Sulfur is also found in garlic, onions and broccoli.

People take sulfur by mouth for shortness of breath, allergies, swelling in the back of the throat (pharyngitis), high cholesterol, clogged arteries, menopause, and upper respiratory tract infections like the common cold. Sulfur seems to have an antibacterial activity. It has been also used for acne.

Structure
Thumb
Synonyms
  • Cyclooctasulfur
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Sodium Sulfacetamide and SulfurKit1250 mg/25gPerrigo New York Inc.2008-10-082012-02-01Us
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
5s Blemish TreatmentCream3 %TopicalShiseido Company Ltd.2000-09-152003-07-01Canada
Acne Blemish Cream(sulfur Cream)Cream4 %TopicalBonne Bell Llc1987-12-311999-07-07Canada
Acne LotionSulfur SulfurLotion30 mg/1mLTopicalAllure Labs Inc2018-11-09Not applicableUs
Acne LotionSulfur SulfurLotion30 mg/1mLTopicalAllure Labs, Inc.2014-06-10Not applicableUs
Acne Treatment Sulfur Wash Rodan and FieldLiquid3 g/100mLTopicalRodan & Fields2011-06-08Not applicableUs
Acnefree Therapeutic Sulfur MaskCream35 g/1gTopicalValeant Pharmaceuticals North America2014-09-09Not applicableUs
Activ O2 Acne Treatment CreamCream10 g/100mLTopicalActiv Ozone (Pty) Ltd2017-09-27Not applicableUs
Alba Botanica Fast Fix for PimpleCream6 g/100gTopicalThe Hain Celestial Group2016-01-21Not applicableUs
Almay Trouble Spotter Acne Pimple MedicationCream5 %TopicalAlmay Toronto Inc.1993-12-311996-09-09Canada
Amino Mask BioelementsCream5 g/100mLTopicalBioelements2013-06-14Not applicableUs
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

    Learn more
  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Acne Aid GelOctasulfur (2.5 %) + Chloroxylenol (.375 %) + Resorcinol (1.25 %)GelTopicalStiefel Laboratories, Inc.1966-12-311998-07-09Canada
Acne Clearning Treatment FaceOctasulfur (.012 mg/.024mg) + Benzoyl peroxide (.006 mg/.024mg) + Salicylic acid (.0048 mg/.024mg)LiquidTopicalCare Pluss Pharma S.A. De C.V.2012-08-06Not applicableUs
Acne Treatment maximum strength CVSOctasulfur (8 g/100g) + Resorcinol (2 g/100g)CreamTopicalCVS Health2014-12-26Not applicableUs
Acne Vanishing Gel- 10% with SulfurOctasulfur (3 g/100mL) + Benzoyl peroxide (10 g/100mL)GelTopicalOnly Yourx, Inc.2014-03-28Not applicableUs
Acnomel Skin Tone CreamOctasulfur (8 %) + Isopropyl alcohol (11 %) + Resorcinol (2 %)CreamTopicalNumark Laboratories, Inc.1992-12-312004-07-30Canada
Acnotex acne TreatmentOctasulfur (80 mg/1mL) + Resorcinol (20 mg/1mL)LotionTopicalGenesis2011-07-072015-03-01Us
Actinac PwrOctasulfur (320 mg) + Allantoin (24 mg) + Chloramphenicol (40 mg) + Hydrocortisone acetate (40 mg) + Nicoboxil (24 mg)PowderTopicalRoussel Canada Inc.1978-12-311996-09-09Canada
Actinac PwsOctasulfur (320 mg) + Allantoin (24 mg) + Chloramphenicol (40 mg) + Hydrocortisone acetate (40 mg) + Nicoboxil (24 mg)Powder, for solutionTopicalHoechst Roussel Canada Inc.1994-12-312001-07-20Canada
Adult AcnomelOctasulfur (80 mg/1g) + Resorcinol (20 mg/1g)CreamTopicalNumark Brands, Inc1946-10-08Not applicableUs
Adult Acnomel TintedOctasulfur (8 g/100g) + Resorcinol (2 g/100g)CreamTopicalDenison Pharmaceuticals, Inc.2017-01-01Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
AvarOctasulfur (50 mg/1g) + Sulfacetamide sodium (95 mg/1g)Aerosol, foamTopicalMission Pharmacal Company2010-07-152019-05-31Us
AvarOctasulfur (50 mg/1g) + Sulfacetamide sodium (100 mg/1g)EmulsionTopicalMission Pharmacal Company2011-09-15Not applicableUs
Avar Cleansing PadsOctasulfur (50 mg/1g) + Sulfacetamide sodium (95 mg/1g)ClothTopicalMission Pharmacal Company2011-09-152019-11-30Us
Avar LSOctasulfur (20 mg/1g) + Sulfacetamide sodium (100 mg/1g)Aerosol, foamTopicalMission Pharmacal Company2010-07-152019-09-30Us
Avar LsOctasulfur (20 mg/1g) + Sulfacetamide sodium (100 mg/1g)EmulsionTopicalMission Pharmacal Company2011-09-15Not applicableUs
Avar LS Cleansing PadsOctasulfur (20 mg/1g) + Sulfacetamide sodium (100 mg/1g)ClothTopicalMission Pharmacal Company2011-09-152019-11-30Us
Avar-eOctasulfur (50 mg/1g) + Sulfacetamide sodium (100 mg/1g)CreamTopicalMission Pharmacal Company2011-09-15Not applicableUs
Avar-e GreenOctasulfur (50 mg/1g) + Sulfacetamide sodium (100 mg/1g)CreamTopicalMission Pharmacal2011-09-15Not applicableUs
Avar-e LSOctasulfur (20 mg/1g) + Sulfacetamide sodium (100 mg/1g)CreamTopicalMission Pharmacal Company2011-09-15Not applicableUs
BEYOND THE SHAVE For MenOctasulfur (3.0 g/100mL) + Allantoin (0.5 g/100mL) + Avobenzone (3.0 g/100mL) + Dimethicone (2.9 g/100mL) + Homosalate (2.5 g/100mL) + Octisalate (5 g/100mL) + Octocrylene (2.7 g/100mL)KitTopicalRodan & Fields2017-06-01Not applicableUs
Categories
UNII
70FD1KFU70
CAS number
10544-50-0
Weight
Average: 256.52
Monoisotopic: 255.77656552
Chemical Formula
S8
InChI Key
JLQNHALFVCURHW-UHFFFAOYSA-N
InChI
InChI=1S/S8/c1-2-4-6-8-7-5-3-1
IUPAC Name
octathiocane
SMILES
S1SSSSSSS1

Pharmacology

Indication

Topically it is indicated for dandruff, acne, Hayfever, common cold, scaly and red skin patches (seborrheic dermatitis). Poison ivy, and sumac infections.

Associated Conditions
Pharmacodynamics

Sulfur is converted to hydrogen sulfide (H2S) through reduction, partly by bacteria. H2S has a lethal action on bacteria (possibly including Propionibacterium acnes) which plays a role in acne, fungi, and parasites such as scabies mites.

Mechanism of action

Sulfur acts as a keratolytic agent and also it has antibacterial activity. It also kills fungi, scabies mites and other parasites. Precipitated sulfur and colloidal sulfur are used, in form of lotions, creams, powders, soaps, and bath additives, for the treatment of acne vulgaris, acne rosacea, and seborrhoeic dermatitis.

Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption

Intended for local use only, no systemic absorption.

Volume of distribution

Intended for local use only, no systemic absorption.

Protein binding

Intended for local use only, no systemic absorption.

Metabolism

Intended for local use only, no systemic absorption.

Route of elimination

Intended for local use only, no systemic absorption.

Half life

Intended for local use only, no systemic absorption.

Clearance

Intended for local use only, no systemic absorption.

Toxicity

rat oral LD50 of greater than 5,000 mg/kg (3, 10); and greater than 8,437 mg/kg.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. webmd [Link]
  2. wikipedia [Link]
  3. MSDS [Link]
External Links
PubChem Compound
66348
PubChem Substance
347827834
ChemSpider
59726
ChEBI
29385
HET
PS9
Wikipedia
Octasulfur
ATC Codes
D10AB02 — Sulfur
AHFS Codes
  • 84:28.00 — Keratolytic Agents
PDB Entries
3hyv / 3hyw / 3hyx / 5jr5

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentHeart Valve Diseases / Nonvalvular Atrial Fibrillation / Thrombosis, Venous1
2, 3CompletedTreatmentBMI >27 kg/m2 / Pregnancy / Psychiatric Disorder NOS1
3Not Yet RecruitingTreatmentBleeding Post-mechanical Valve Replacement / Thromboembolism Post-mechanical Valve Replacement1
4Unknown StatusTreatmentTreatment of Acne Vulgaris Grade II in a Short Period of Time1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
GelTopical
CreamTopical4 %
LotionTopical30 mg/1mL
LiquidTopical3 g/100mL
CreamTopical35 g/1g
CreamTopical
PowderTopical
Powder, for solutionTopical
CreamTopical10 g/100mL
CreamTopical6 g/100g
CreamTopical5 %
CreamTopical5 g/100mL
SoapTopical10 g/100g
LiquidVaginal0.12 mg/3mL
PowderTopical30 mg/1g
CreamTopical30 mg/1mL
CreamTopical5 mL/100mL
LiquidTopical10 mL/100mL
CreamTopical10 mg/100mL
TabletOral
Aerosol, foamTopical
CreamTopical50 mg/1g
PasteTopical
EmulsionTopical
LotionTopical10 %
CreamTopical0.28 g/2.8g
LotionTopical100 mg/1mL
LotionTopical50 mg/1mL
PasteTopical100 mg/1g
CreamTopical0.10 g/1g
SoapTopical5 g/85g
CreamTopical6 mg/0.2g
CreamTopical0.48750 g/15mL
LotionTopical1.5 g/50mL
SoapTopical3 g/100g
CreamTopical5 g/100g
PowderTopical3 g/100g
Lotion, augmentedTopical.05 g/1g
Lotion, augmentedTopical.05 g/1mL
GelTopical0.033 g/1g
LiquidTopical10 g/100mL
GelTopical3 g/100mL
LotionTopical5 g/100mL
LotionTopical100 mg/1g
SoapTopical2 g/100g
SuspensionTopical25 mg/1mL
CreamTopical64 mg/1g
SoapTopical3.0 g/100g
OintmentTopical1.5 g/15mL
LotionTopical6.3 1/95mL
SoapTopical9 g/100g
LotionTopical1.4 g/14mL
CreamTopical1.12 g/28g
SoapTopical3 %
PowderTopical3 1/100g
PatchTransdermal9 mg/9mg
LotionTopical0.9 g/30mL
PasteTopical120 mg/1mL
LiquidTopical10 g/1mL
Kit
CreamTopical3 %
LotionTopical2 %
SuspensionTopical
GelTopical6 mg/100mL
LotionTopical8 mg/100mL
CreamTopical0.06 g/1g
LotionTopical6 g/100g
LotionTopical10 g/100mL
SuspensionTopical1.4 g/14g
LiquidTopical1.4 g/14g
CreamTopical3 mL/100mL
SoapTopical
Liquid; shampooTopical
SwabTopical
RinseTopical
Kit1250 mg/25g
KitTopical
SolutionTopical
PowderTopical
PowderOral; Topical
ShampooTopical0.4 mL/100mL
CreamTopical0.1 g/100g
ShampooTopical
SoapTopical5 %
LiquidTopical
SoapTopical0.33 g/1
ClothTopical
SoapTopical30 mg/1g
LotionTopical
OintmentTopical10 g/100g
OintmentTopical2 %
CreamTopical10 g/100g
LiquidTopical0.03 g/1g
PasteTopical3.5 mg/1mL
PowderOral
SoapTopical5.0 g/100g
OintmentTopical10 %
OintmentTopical20 mg/1g
CreamTopical6 g/60mL
CreamTopical35 g/1000g
OintmentTopical
LiquidTopical.003 mg/.06mg
CreamTopical0.1 g/1mL
CreamTopical8 %
LotionTopical6 g/100mL
CapsuleOral
PowderOral; Topical
CreamTopical100 mg/1g
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP4.76ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity46.05 m3·mol-1ChemAxon
Polarizability20.4 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
GC-MS Spectrum - EI-BGC-MSsplash10-08fr-8970000000-05d363b8af247651039a
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as other non-metal sulfides. These are inorganic compounds containing a sulfur atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen belongs to the class of other non-metals.
Kingdom
Inorganic compounds
Super Class
Homogeneous non-metal compounds
Class
Other non-metal organides
Sub Class
Other non-metal sulfides
Direct Parent
Other non-metal sulfides
Alternative Parents
Inorganic sulfides
Substituents
Other non-metal sulfide / Inorganic sulfide
Molecular Framework
Not Available
External Descriptors
homomonocyclic compound, elemental sulfur (CHEBI:29385)

Drug created on November 30, 2015 12:10 / Updated on July 18, 2019 19:06