Sulfur

Identification

Name
Sulfur
Accession Number
DB09353
Type
Small Molecule
Groups
Approved
Description

Sulfur is a chemical element that is present in all living tissues. After calcium and phosphorus, it is the third most abundant mineral in the human body. Sulfur is also found in garlic, onions and broccoli.

People take sulfur by mouth for shortness of breath, allergies, swelling in the back of the throat (pharyngitis), high cholesterol, clogged arteries, menopause, and upper respiratory tract infections like the common cold. Sulfur seems to have an antibacterial activity. It has been also used for acne.

Structure
Thumb
Synonyms
Not Available
Product Ingredients
IngredientUNIICASInChI Key
Sulfur chlorideNJ7YR2EV0D10025-67-9PXJJSXABGXMUSU-UHFFFAOYSA-N
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
5s Blemish TreatmentCream3 %TopicalShiseido Company Ltd.2000-09-152003-07-01Canada
Acne Blemish Cream(sulfur Cream)Cream4 %TopicalBonne Bell Llc1987-12-311999-07-07Canada
Acne LotionSulfur SulfurLotion30 mg/mLTopicalAllure Labs, Inc.2014-06-10Not applicableUs
Acne Treatment Sulfur Wash Rodan and FieldLiquid3 g/100mLTopicalRodan & Fields2011-06-08Not applicableUs
Acnefree Therapeutic Sulfur MaskCream35 g/gTopicalValeant Pharmaceuticals North America2014-09-09Not applicableUs
Activ O2 Acne Treatment CreamCream10 g/100mLTopicalActiv Ozone (Pty) Ltd2017-09-27Not applicableUs
Almay Trouble Spotter Acne Pimple MedicationCream5 %TopicalAlmay Toronto Inc.1993-12-311996-09-09Canada
Amino Mask BioelementsCream5 g/100mLTopicalBioelements2013-06-14Not applicableUs
Anti Acne Natural Volcanic SulfurSoap10 g/100gTopicalPt Galenium Pharmasia Laboratories2012-10-01Not applicableUs
Anti-Bac Concentrate Bioelements, Inc.Cream5 mL/100mLTopicalBioelements2010-09-092017-06-23Us
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Acne Aid GelSulfur (2.5 %) + Chloroxylenol (.375 %) + Resorcinol (1.25 %)GelTopicalStiefel Laboratories, Inc.1966-12-311998-07-09Canada
Acne Clearning Treatment FaceSulfur (.012 mg/.024mg) + Benzoyl peroxide (.006 mg/.024mg) + Salicylic acid (.0048 mg/.024mg)LiquidTopicalCare Pluss Pharma S.A. De C.V.2012-08-06Not applicableUs
Acne Treatment maximum strength CVSSulfur (8 g/100g) + Resorcinol (2 g/100g)CreamTopicalCvs Health2014-12-26Not applicableUs
Acnomel Skin Tone CreamSulfur (8 %) + Isopropyl Alcohol (11 %) + Resorcinol (2 %)CreamTopicalNumark Laboratories, Inc.1992-12-312004-07-30Canada
Actinac PwrSulfur (320 mg) + Allantoin (24 mg) + Chloramphenicol (40 mg) + Hydrocortisone acetate (40 mg) + Nicoboxil (24 mg)PowderTopicalRoussel Canada Inc.1978-12-311996-09-09Canada
Actinac PwsSulfur (320 mg) + Allantoin (24 mg) + Chloramphenicol (40 mg) + Hydrocortisone acetate (40 mg) + Nicoboxil (24 mg)Powder, for solutionTopicalHoechst Roussel Canada Inc.1994-12-312001-07-20Canada
Adult AcnomelSulfur (80 mg/g) + Resorcinol (20 mg/g)CreamTopicalNumark Brands, Inc1946-10-08Not applicableUs
Anti-acne Formula for MenSulfur (3.75 %) + Salicylic acid (1 %)CreamTopicalClinique Laboratories Dist1987-12-311998-08-26Canada
Anti-acne Formula-lightSulfur (3.75 %) + Salicylic acid (1 %)CreamTopicalClinique Laboratories Dist1986-12-311996-09-09Canada
Anti-acne Formula-mediumSulfur (3.75 %) + Salicylic acid (1 %)CreamTopicalClinique Laboratories Dist1986-12-311996-09-09Canada
Categories
UNII
70FD1KFU70
CAS number
Not Available
Weight
Average: 256.52
Monoisotopic: 255.77656552
Chemical Formula
S8
InChI Key
JLQNHALFVCURHW-UHFFFAOYSA-N
InChI
InChI=1S/S8/c1-2-4-6-8-7-5-3-1
IUPAC Name
octathiocane
SMILES
S1SSSSSSS1

Pharmacology

Indication

Topically it is indicated for dandruff, acne, Hayfever, common cold, scaly and red skin patches (seborrheic dermatitis). Poison ivy, and sumac infections.

Structured Indications
Pharmacodynamics

Sulfur is converted to hydrogen sulfide (H2S) through reduction, partly by bacteria. H2S has a lethal action on bacteria (possibly including Propionibacterium acnes) which plays a role in acne, fungi, and parasites such as scabies mites.

Mechanism of action

Sulfur acts as a keratolytic agent and also it has antibacterial activity. It also kills fungi, scabies mites and other parasites. Precipitated sulfur and colloidal sulfur are used, in form of lotions, creams, powders, soaps, and bath additives, for the treatment of acne vulgaris, acne rosacea, and seborrhoeic dermatitis.

Absorption

Intended for local use only, no systemic absorption.

Volume of distribution

Intended for local use only, no systemic absorption.

Protein binding

Intended for local use only, no systemic absorption.

Metabolism

Intended for local use only, no systemic absorption.

Route of elimination

Intended for local use only, no systemic absorption.

Half life

Intended for local use only, no systemic absorption.

Clearance

Intended for local use only, no systemic absorption.

Toxicity

rat oral LD50 of greater than 5,000 mg/kg (3, 10); and greater than 8,437 mg/kg.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. webmd [Link]
  2. wikipedia [Link]
  3. MSDS [Link]
External Links
ChemSpider
59726
ChEBI
29385
HET
PS9
ATC Codes
D10AB02 — Sulfur
AHFS Codes
  • 84:28.00 — Keratolytic Agents
  • 88:29.00* — Minerals
PDB Entries
3hyv / 3hyw / 3hyx / 5jr5

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2, 3CompletedTreatmentBMI >27 kg/m2 / Pregnancy / Psychiatric Disorder NOS1
4Unknown StatusTreatmentTreatment of Acne Vulgaris Grade II in a Short Period of Time1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
CreamTopical4 %
LotionTopical30 mg/mL
CreamTopical35 g/g
PowderTopical
Powder, for solutionTopical
CreamTopical5 %
CreamTopical5 g/100mL
SoapTopical10 g/100g
LiquidVaginal.12 mg/3mL
Aerosol, foamTopical
PowderTopical30 mg/g
CreamTopical30 mg/mL
CreamTopical5 mL/100mL
LiquidTopical10 mL/100mL
LiquidTopical
TabletOral
CreamTopical50 mg/g
PasteTopical
LotionTopical10 %
CreamTopical5 g/100g
CreamTopical
LotionTopical100 mg/g
CreamTopical.28 g/2.8g
LotionTopical50 mg/mL
CreamTopical32.5 mg/g
PasteTopical100 mg/g
SoapTopical5 g/85g
CreamTopical6 mg/.2g
CreamTopical.4875 g/15mL
LotionTopical1.5 g/50mL
CreamTopical10 g/100g
PowderTopical3 g/100g
Lotion, augmentedTopical.05 g/g
Lotion, augmentedTopical.05 g/mL
LiquidTopical10 g/100mL
LotionTopical5 g/100mL
SoapTopical2 g/100g
CreamTopical64 mg/g
SoapTopical3 g/100g
OintmentTopical1.5 g/15mL
LotionTopical6.3 1/95mL
LotionTopical100 mg/mL
LiquidTopical3 g/100mL
CreamTopical10 g/100mL
LotionTopical1.4 g/14mL
CreamTopical1.12 g/28g
SoapTopical3 %
PowderTopical3 1/100g
PatchTransdermal9 mg/9mg
LotionTopical.9 g/30mL
TabletOral0.015 mg
LiquidTopical10 g/mL
CreamTopical3 %
LotionTopical2 %
SoapTopical
GelTopical6 mg/100mL
LotionTopical8 mg/100mL
LotionTopical6 g/100g
CreamTopical.06 g/g
CreamTopical6 g/100g
LotionTopical10 g/100mL
SuspensionTopical1.4 g/14g
CreamTopical3 mL/100mL
KitTopical
SolutionTopical
ShampooTopical
Liquid; shampooTopical
PowderOral; Topical
CapsuleOral
SwabTopical
ClothTopical
RinseTopical
EmulsionTopical
GelTopical
SuspensionTopical
PowderTopical
PowderOral; Topical
ShampooTopical.4 mL/100mL
CreamTopical.1 g/100g
SoapTopical5 %
LotionTopical
SoapTopical.33 g/1
OintmentTopical10 g/100g
OintmentTopical2 %
LiquidTopical.03 g/g
SoapTopical5 g/100g
OintmentTopical10 %
Kit
CreamTopical35 g/1000g
OintmentTopical
LiquidTopical.003 mg/.06mg
CreamTopical8 %
LotionTopical6 g/100mL
CreamTopical100 mg/g
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP4.76ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity46.05 m3·mol-1ChemAxon
Polarizability20.4 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
GC-MS Spectrum - EI-BGC-MSsplash10-08fr-8970000000-05d363b8af247651039a
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as other non-metal sulfides. These are inorganic compounds containing a sulfur atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen belongs to the class of other non-metals.
Kingdom
Inorganic compounds
Super Class
Homogeneous non-metal compounds
Class
Other non-metal organides
Sub Class
Other non-metal sulfides
Direct Parent
Other non-metal sulfides
Alternative Parents
Inorganic sulfides
Substituents
Other non-metal sulfide / Inorganic sulfide
Molecular Framework
Not Available
External Descriptors
homomonocyclic compound, elemental sulfur (CHEBI:29385)

Drug created on November 30, 2015 12:10 / Updated on October 23, 2017 14:13