Chloroxylenol

Identification

Name
Chloroxylenol
Accession Number
DB11121
Type
Small Molecule
Groups
Approved
Description

Chloroxylenol, also known as para-chloro-meta-xylenol (PCMX), is an antiseptic and disinfectant agent used for skin disinfection and cleaning surgical instruments. It is also commonly used in antibacterial soaps, wound-cleansing applications and household antiseptics. The halophenol is shown to be most effective against Gram positive bacteria where it disrupts the cell wall due to its phenolic nature [1]. Chloroxylenol is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.

Structure
Thumb
Synonyms
  • 2-chloro-5-hydroxy-1,3-dimethylbenzene
  • 2-chloro-5-hydroxy-m-xylene
  • 2-Chloro-m-xylenol
  • 3,5-dimethyl-4-chlorophenol
  • 4-chloro-1-hydroxy-3,5-dimethylbenzene
  • 4-chloro-3,5-dimethylphenol
  • 4-chloro-m-xylenol
  • chloro-xylenol
  • p-chloro-3,5-xylenol
  • p-chloro-m-xylenol
  • parachlorometaxylenol
  • PCMX
Active Moieties
NameKindUNIICASInChI Key
Phenolunknown339NCG44TV108-95-2ISWSIDIOOBJBQZ-UHFFFAOYSA-N
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
1012 AntimicrobialSoap3 mg/1mLTopicalAbc Compounding Co. Inc.2013-05-01Not applicableUs
986 Antiseptic Hand Soap-lot 0.5%Lotion0.5 %TopicalFuller Brush/Les Brosses Fuller1994-12-311995-08-01Canada
ACQUAINT Antibacterial Foam HandwashLiquid0.003 mg/1mLTopicalGOJO Industries, Inc.2004-09-09Not applicableUs
Acute Kare Hand Sp.Solution0.5 g/100mLTopicalDeb Canada2017-03-012017-03-01Us
Acute-Kare Healthcare Personnel HandwashSoap1 g/100mLTopicalDeb Canada2018-02-01Not applicableUs
Acute-Kare Healthcare Personnel HandwashSoap1 g/100mLTopicalSTERIS Corporation1995-01-17Not applicableUs
adriana GoldLiquid0.3 g/100mLTopicalOstl, Inc.2018-01-31Not applicableUs
ADVANTAGE CHEMICAL Premium Antibacterial Foaming Hand So apLiquid0.005 mg/1mLTopicalAdvantage Chemical, Inc.2015-04-15Not applicableUs
Aero CleansE2 AntibacterialLiquid2.1 mL/100mLTopicalDeb Canada2010-01-01Not applicableUs
Aero Florafree AntibacterialLiquid0.5 mL/100mLTopicalDeb Canada2010-01-01Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Absorbine Jr Extra Strength LinimentChloroxylenol (0.5 %) + Menthol (4.0 %)LiquidTopicalClarion Brands, Llc1992-12-31Not applicableCanada
Absorbine Jr LinimentChloroxylenol (0.5 %) + Menthol (1.25 %)LiquidTopicalClarion Brands, Llc1993-12-31Not applicableCanada
Absorbine Power GelChloroxylenol (.5 %) + Menthol (4 %)GelTopicalW.F. Young, Inc.1993-12-31Not applicableCanada
Acne Aid GelChloroxylenol (.375 %) + Octasulfur (2.5 %) + Resorcinol (1.25 %)GelTopicalStiefel Laboratories, Inc.1966-12-311998-07-09Canada
Acropole BleuChloroxylenol (.15 %) + Phenoxyethanol (.45 %)JellyTopicalParall LtÉe1997-10-012001-07-23Canada
AntimicrobialChloroxylenol (0.45 g/100mL) + Triclosan (0.06 g/100mL)SoapTopicalSky Systems Co., Inc1990-12-10Not applicableUs
Blistex Foille Medicated First AidChloroxylenol (0.1 g/100g) + Benzocaine (5 g/100g)OintmentTopicalBlistex Corporation2013-03-05Not applicableUs
Contend Anti-bacterial Gel Skin CleanserChloroxylenol (.15 %) + Triclosan (.15 %)GelTopicalSbs Products1993-12-311997-07-23Canada
Cosmos HvChloroxylenol (.15 %) + Phenoxyethanol (.45 %)LiquidTopicalParall LtÉe1996-12-182004-05-25Canada
D-COL Personal Hygiene Convenience kitChloroxylenol (2.4 mg/1mL) + Pyrithione zinc (10 mg/1mL)KitD-COL Inc2018-05-30Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Antibacterial FoamChloroxylenol (5 mL/1000mL)SoapTopicalSanihealth Products Corporation2010-05-18Not applicableUs
Cortaine -B AqueousChloroxylenol (1 mg/1mL) + Hydrocortisone (10 mg/1mL) + Pramoxine hydrochloride (10 mg/1mL)Solution / dropsAuricular (otic)Physicians Total Care, Inc.2010-09-092013-01-15Us
Cortane-BChloroxylenol (1 mg/1mL) + Hydrocortisone (10 mg/1mL) + Pramoxine hydrochloride (10 mg/1mL)LotionTopicalBlansett Pharmacal Co2017-03-20Not applicableUs
Hydro EarChloroxylenol (1 mg/1mL) + Benzalkonium chloride (0.1 mg/1mL) + Hydrocortisone (10 mg/1mL) + Pramoxine hydrochloride (10 mg/1mL)Solution / dropsAuricular (otic)Hi Tech Pharmacal Co., Inc.2002-08-012011-10-27Us
MyOxinChloroxylenol (1 mg/1mL) + Benzocaine (15 mg/1mL) + Hydrocortisone acetate (10 mg/1mL)SolutionTopicalGM Pharamceuticals, Inc2011-08-012013-02-14Us
Oti RxChloroxylenol (1 mg/1mL) + Hydrocortisone (10 mg/1mL) + Pramoxine hydrochloride (10 mg/1mL)LiquidAuricular (otic)Breckenridge Pharmaceutical, Inc.2003-08-012012-01-31Us
OticinChloroxylenol (0.01 g/10mL) + Pramoxine hydrochloride (0.1 g/10mL)Solution / dropsAuricular (otic)Teral, Inc.2009-11-122015-09-28Us
Oticin HC Ear DropsChloroxylenol (0.01 g/10mL) + Hydrocortisone (0.1 g/10mL) + Pramoxine hydrochloride (0.01 g/10mL)Solution / dropsAuricular (otic)Teral, Inc.2009-11-122015-09-28Us
Oto End 10Chloroxylenol (1 mg/1mL) + Hydrocortisone (10 mg/1mL) + Pramoxine hydrochloride (10 mg/1mL)Solution / dropsAuricular (otic)Larken Laboratories, Inc.2007-10-122015-09-28Us
Pramoxine-HCChloroxylenol (1 mg/1mL) + Hydrocortisone (10 mg/1mL) + Pramoxine hydrochloride (10 mg/1mL)LiquidAuricular (otic)Kylemore Pharmaceuticals, LLC2010-01-052011-03-16Us
Categories
UNII
0F32U78V2Q
CAS number
88-04-0
Weight
Average: 156.61
Monoisotopic: 156.0341926
Chemical Formula
C8H9ClO
InChI Key
OSDLLIBGSJNGJE-UHFFFAOYSA-N
InChI
InChI=1S/C8H9ClO/c1-5-3-7(10)4-6(2)8(5)9/h3-4,10H,1-2H3
IUPAC Name
4-chloro-3,5-dimethylphenol
SMILES
CC1=CC(O)=CC(C)=C1Cl

Pharmacology

Indication

The predominant medical applications for which chloroxylenol is formally indicated for therapeutic use is as an application to the skin for use in cuts, bites, stings, abrasions, and for use as antiseptic hand cleaner [7].

Pharmacodynamics

Chloroxylenol is a substituted phenol which has been widely used for many years as an ingredient of antiseptic and disinfectant products intended for external use [9]. It is known to be bactericidal in low concentration to a wide range of Gram positive and Gram negative bacteria [9].

Mechanism of action

As a phenol antiseptic, it is believed that the hydroxyl -OH groups of the chloroxylenol molecule binds to certain proteins on the cell membrane of bacteria, and disrupts the membrane so as to allow the contents of the bacterial cell to leak out [1]. This allows chloroxylenol to enter the bacterial cell to bind further with more proteins and enzymes to disable the cell's functioning [1]. At particularly high concentrations of chloroxylenol, the protein and nucleic acid content of targeted bacterial cells become coagulated and cease to function, leading to rapid cell death [1].

Absorption

No chloroxylenol was detected in the blood following the dermal administration of 2 g of p-chloroxylenol in an ethanol/olive oil vehicle in human subjects [3]. After a dose of 5 g, only traces were found, after 8 g, 1 mg % (1 mg/dL) was found in the blood after 3 hours, and 4 mg % (4 mg/dL) after 24 hours [3]. After a dose of 20 g, 4 mg % (4 mg/dL) was measured after half an hour, and 1 mg % (1 mg/dL) was present at 72 hours [3].

For antiseptic purposes, chloroxylenol is considered to be well-absorbed when applied to the skin [9].

Volume of distribution

The only data available regarding the volume of distribution of chloroxylenol is the mean Vss of 22.45 L determined after 200 mg intravenous single dose of chloroxylenol was administered to healthy mongrel dog subjects [6, 8].

Protein binding

One study determined the protein binding of chloroxylenol to be approximately 85.2% +/- 2.32% for serum albumin and 89.8% +/- 2.99% for whole human serum [2].

Metabolism

Certain animal studies have shown that following dermal application of chloroxylenol, that the absorption was rapid with a Cmax = 1-2 hours, and that the administered substance was excreted via the kidney with almost complete elimination within 24 hours [7]. The primary metabolites discovered in the excreted urine were glucuronides and sulfates [7]. Some chloroxylenol monographs liken its pharmacokinetic profile to that of another antiseptic - triclosan - which is rapidly excreted in the urine also as a glucuronide metabolite, as observed in the human model [7].

Moreover, In one human subject administered 5 mg intragluteally, 14% was excreted with glucuronic acid and 17% with sulfuric acid at 3 days [4].

Any chloroxylenol absorbed into the body is likely extensively metabolized by the liver and rapidly excreted, mainly in the urine, as sulphate and glucuronide conjugates [9].

Route of elimination

The major route of excretion is likely in urine [8, 7], although some amounts may be found in bile and traces in exhaled air [6].

Half life

One study estimated the mean terminal half-life and mean residence time after a 200 mg intravenous single dose of chloroxylenol in healthy mongrel dog subjects to be 1.7 and 1.69 hours, respectively [6, 8]. Alternatively, some product monographs liken chloroxylenol to a similar liquid antiseptic, triclosan, whose calculated urinary excretion half-life in man is approximately 10 hours [7].

Clearance

The only data available regarding the clearance of chloroxylenol is the mean clearance rate of 13.76 L/hr following a 200 mg intravenous single dose of the substance into healthy mongrel dog subjects [6, 8].

Moreover, in another study, when 8 g of chloroxylenol was administered dermal on a human subject in an alcohol/glycerin vehicle, 11% was excreted in 48 hours [4].

Toxicity

As chloroxylenol is predominantly employed as an active ingredient in various liquids or creams as cleaners, disinfectants, or antiseptics that are generally designed to be used topically, it is widely accepted that the use of such liquids - when used appropriately - is unlikely to present a sufficient volume that could be ingested to cause any medical problems [7]. In the event of accidental eye contact, was with Luke warm water [7].

Chloroxylenol is known to have a low systemic toxicity, even at dosage levels many times higher that those likely to be absorbed during normal usage of the agent [9].

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
AcetaminophenAcetaminophen may decrease the excretion rate of Chloroxylenol which could result in a higher serum level.
Acetylsalicylic acidAcetylsalicylic acid may decrease the excretion rate of Chloroxylenol which could result in a higher serum level.
AlprazolamAlprazolam may decrease the excretion rate of Chloroxylenol which could result in a higher serum level.
AmilorideAmiloride may increase the excretion rate of Chloroxylenol which could result in a lower serum level and potentially a reduction in efficacy.
AmitriptylineChloroxylenol may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
AmlodipineAmlodipine may decrease the excretion rate of Chloroxylenol which could result in a higher serum level.
AmoxicillinAmoxicillin may decrease the excretion rate of Chloroxylenol which could result in a higher serum level.
AmphetamineAmphetamine may decrease the excretion rate of Chloroxylenol which could result in a higher serum level.
AmpicillinAmpicillin may decrease the excretion rate of Chloroxylenol which could result in a higher serum level.
AuranofinAuranofin may decrease the excretion rate of Chloroxylenol which could result in a higher serum level.
Food Interactions
Not Available

References

General References
  1. McDonnell G, Russell AD: Antiseptics and disinfectants: activity, action, and resistance. Clin Microbiol Rev. 1999 Jan;12(1):147-79. [PubMed:9880479]
  2. Judis J: Binding of selected phenol derivatives to human serum proteins. J Pharm Sci. 1982 Oct;71(10):1145-7. [PubMed:7143213]
  3. ZONDEK B, FINKELSTEIN M: Blood concentration of P-chloro-xylenol in man following parenteral, percutaneous and rectal application. Proc Soc Exp Biol Med. 1946 Feb;61:200-2. [PubMed:21017619]
  4. Zondek B, Shapiro B: Fate of halogenated phenols in the organism. Biochem J. 1943;37(5):592-5. [PubMed:16747702]
  5. US EPA Reregistration Eligibility Decision (RED): Chloroxylenol [Link]
  6. Exponent FDA Consumer Antispetics Rule: FDA Request for Data on Safety and Efficacy of Chloroxylenol [Link]
  7. Electronic Medicines Compendium: Dettol (Chloroxylenol) Antiseptic Cream Monograph [Link]
  8. NLM Toxnet: Chloroxylenol [Link]
  9. Electronic Medicines Compendium: Dettol (chloroxylenol) Liquid Monograph [Link]
External Links
KEGG Drug
D03473
KEGG Compound
C14715
PubChem Compound
2723
PubChem Substance
347827904
ChemSpider
21106017
ChEBI
34393
ChEMBL
CHEMBL398440
Wikipedia
Chloroxylenol
ATC Codes
D08AE05 — Chloroxylenol
AHFS Codes
  • 84:04.92 — Miscellaneous Local Anti-infectives
MSDS
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Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0Active Not RecruitingBasic ScienceAging / Menopause1
0Active Not RecruitingTreatmentUlcerative Colitis, Active Moderate1
0RecruitingBasic ScienceObstructive Sleep Apnea of Adult1
0RecruitingSupportive CarePostoperative pain1
0RecruitingTreatmentPostoperative pain1
0RecruitingTreatmentRespiratory Syncytial Virus (RSV)1
0Unknown StatusBasic ScienceHeart Failure, Unspecified / Hepatic Failure / Renal Failure / Respiratory Failure / Transplantations1
1Active Not RecruitingBasic SciencePsychiatric Disorder NOS / Psychotic Disorder NOS / Schizophrenic Disorders1
1CompletedBasic ScienceBypass, Gastric / Gastric Banding / Post-gastrointestinal bypass surgery / Roux-en-Y Gastric Bypass / Vertical Sleeve Gastrectomy1
1CompletedBasic ScienceFunctional Gastrointestinal Disorders1
1CompletedBasic SciencePre-Diabetic1
1CompletedPreventionBacillus Anthracis (Anthrax) Infection1
1CompletedSupportive CareHuman Immunodeficiency Virus (HIV) Infections1
1CompletedTreatmentAging1
1CompletedTreatmentAlcohol Use Disorders (AUD)1
1CompletedTreatmentDiabetes, Diabetes Mellitus Type 11
1CompletedTreatmentHepatitis, Chronic Active1
1CompletedTreatmentIdiopathic Pulmonary Arterial Hypertension1
1CompletedTreatmentKidney Failure, Chronic Therapy; Hemodialysis1
1CompletedTreatmentKnee Osteoarthritis (Knee OA)1
1CompletedTreatmentType1diabetes1
1RecruitingOtherRheumatoid Arthritis1
1RecruitingTreatmentAcne Vulgaris1
1RecruitingTreatmentDepression / Parkinson's Disease (PD)1
1RecruitingTreatmentPressure Ulcers1
1TerminatedTreatmentStrokes1
1Unknown StatusNot AvailableDiabetic Macular Ischemia1
1Unknown StatusTreatmentDiabetic Foot Ulcers (DFU)1
1Unknown StatusTreatmentWound Healing1
1, 2Active Not RecruitingTreatmentT2DM With NAFLD1
1, 2CompletedPreventionChronic Lung Disease of Prematurity / Respiratory Distress Syndrome In Premature Infants1
1, 2CompletedPreventionOvarian Hyperstimulation Syndrome2
1, 2CompletedTreatmentAllergic Rhinitis (AR)1
1, 2CompletedTreatmentBrain Injury / Chorioamnionitis1
1, 2CompletedTreatmentCondylomata Acuminata / Papillomavirus Infections / Sexually Transmitted Disease (STD)1
1, 2CompletedTreatmentCrohn's Disease (CD) / Hepatitis B Chronic Infection1
1, 2CompletedTreatmentExtensive-Stage Small Cell Lung Cancer1
1, 2CompletedTreatmentGlaucoma / Ocular Hypertension1
1, 2CompletedTreatmentHeart Failure, Unspecified / Impaired Renal Function1
1, 2CompletedTreatmentLiver Cirrhosis1
1, 2CompletedTreatmentPressure Ulcers / Wound site1
1, 2CompletedTreatmentPrimary Total Knee Arthroplasty1
1, 2CompletedTreatmentSpinal Cord Injuries (SCI)1
1, 2Enrolling by InvitationTreatmentMuscle Weakness / Sepsis1
1, 2Not Yet RecruitingTreatmentAnemias1
1, 2Not Yet RecruitingTreatmentFevers / Intracerebral Hemorrhage / Stroke, Ischemic / Subarachnoid Hemorrhage / Subdural haematoma / Traumatic Brain Injury (TBI)1
1, 2RecruitingTreatmentMetabolic Syndromes1
1, 2RecruitingTreatmentSarcoidosis1
1, 2TerminatedTreatmentCystoid Macular Edema2
1, 2Unknown StatusTreatmentAtypical Parkinsonism / Cerebral Palsy (CP) / Hemorrhagic Strokes / Neurological Diseases / Stroke, Ischemic1
1, 2Unknown StatusTreatmentHepatitis B Chronic Infection1
1, 2Unknown StatusTreatmentPre-Eclampsia, Severe1
2Active Not RecruitingPreventionMeningococcal B Disease1
2Active Not RecruitingPreventionSalmonella Typhi Infection1
2Active Not RecruitingTreatmentAspergillosis, Allergic Bronchopulmonary1
2Active Not RecruitingTreatmentCardiopulmonary Bypass / Surgery, Cardiac1
2Active Not RecruitingTreatmentCystic Fibrosis (CF)1
2Active Not RecruitingTreatmentHeart Failure, Unspecified / Prophylaxis of cardiomyopathy / Ventricular Dysfunction1
2Active Not RecruitingTreatmentHepatic Failure1
2CompletedBasic ScienceAdipose Tissue Inflammation / Obesity, Morbid1
2CompletedOtherComplication Due to Immunization1
2CompletedOtherGlaucoma, Angle-closure, Primary, Acute1
2CompletedPreventionAnesthesia Intubation Complications / High Blood Pressure (Hypertension) / Intubation Complications / Tachycardia / Tracheal Intubation Morbidity1
2CompletedPreventionCardiovascular Disease (CVD) / Heart Diseases / High Blood Pressure (Hypertension) / Hyperlipidemias1
2CompletedPreventionCoronary Artery Disease1
2CompletedPreventionFlu caused by Influenza1
2CompletedPreventionHeart Failure, Unspecified1
2CompletedPreventionHepatectomy, Surgical Blood Loss, Terlipressin1
2CompletedPreventionImmune Tolerance1
2CompletedPreventionInfectious Disease Transmission1
2CompletedPreventionIntrauterine Growth Retardation / Preeclampsia / Premature Births / Small for Gestational Age / Very Low Birth Weight Infant1
2CompletedPreventionMeningococcal Infections / Meningococcal Meningitis1
2CompletedPreventionMumps / Rubella / Rubeola / Varicella2
2CompletedPreventionPostoperative paralytic ileus1
2CompletedSupportive CareEndothelial Dysfunction / Erectile Dysfunction (ED) / Type 2 Diabetes Mellitus1
2CompletedSupportive CarePostoperative Cognitive Dysfunction1
2CompletedSupportive CareRheumatoid Arthritis1
2CompletedTreatmentAge-related Dysphonia / Dysphonia Resulting From Vocal Fold Scarring1
2CompletedTreatmentAllogeneic Stem Cell Transplantation / Obliterative Bronchiolitis1
2CompletedTreatmentAlzheimer's Disease (AD)1
2CompletedTreatmentAndrogen Deficiency / BMI >30 kg/m21
2CompletedTreatmentAndrogenetic Alopecia1
2CompletedTreatmentAnemias1
2CompletedTreatmentApathy / Huntington's Disease (HD)1
2CompletedTreatmentBlood Loss / Terlipressin1
2CompletedTreatmentCerebral Small Vessels Disease / Stroke, Lacunar1
2CompletedTreatmentCessation, Smoking1
2CompletedTreatmentChemotherapy-induced Peripheral Neuropathy (CIPN)1
2CompletedTreatmentCritical Lower Limb Ischemia / Vascular Diseases1
2CompletedTreatmentCystic Fibrosis (CF)4
2CompletedTreatmentDiabetes Mellitus (DM) / Heart Failure, Unspecified1
2CompletedTreatmentDiabetic Macular Edema (DME)1
2CompletedTreatmentGlioblastoma Multiforme (GBM)1
2CompletedTreatmentHead and Neck Carcinoma / Xerostomia1
2CompletedTreatmentHeart Failure, Unspecified / Prophylaxis of cardiomyopathy / Ventricular Dysfunction1
2CompletedTreatmentHemodynamics, Liver, Terlipressin1
2CompletedTreatmentHepatitis, Chronic Active1
2CompletedTreatmentHyperhidrosis1
2CompletedTreatmentInfection, Human Immunodeficiency Virus I1
2CompletedTreatmentIntervertebral Disc Degeneration / Spinal Stenosis / Spondylolisthesis, Degenerative1
2CompletedTreatmentKnee Osteoarthritis (Knee OA)1
2CompletedTreatmentMetastatic Colorectal Cancers1
2CompletedTreatmentMiddle Cerebral Artery Infarction / Strokes1
2CompletedTreatmentMuscle Damage / Muscle Inflammation1
2CompletedTreatmentNausea / Vomiting1
2CompletedTreatmentOpiate Addiction2
2CompletedTreatmentPostherpetic Neuralgia1
2CompletedTreatmentPrimary Apical Periodontite1
2CompletedTreatmentPsoriasis1
2CompletedTreatmentRabies Virus1
2CompletedTreatmentShiga Toxin Producing Bacterial Infection1
2CompletedTreatmentTraumatic Brain Injury (TBI)1
2CompletedTreatmentType 2 Diabetes Mellitus1
2Enrolling by InvitationPreventionDelirium / Hematopoietic Stem Cell Transplantation (HSCT) / Thiamine Deficiency1
2Not Yet RecruitingPreventionCentral Venous Catheter Associated Bloodstream Infection / Central Venous Catheter Thrombosis1
2Not Yet RecruitingPreventionColorectal Neoplasms, Hereditary Nonpolyposis1
2Not Yet RecruitingPreventionPostoperative pain1
2Not Yet RecruitingTreatmentAplastic Anaemia (AA)1
2Not Yet RecruitingTreatmentCoronary Artery Disease / Gene Transfer / Refractory Angina Pectoris1
2Not Yet RecruitingTreatmentCritical Illness / Hypernatremia1
2Not Yet RecruitingTreatmentDexamethasone / Inflammatory Bowel Diseases (IBD) / Postoperative Complications / Postoperative paralytic ileus1
2Not Yet RecruitingTreatmentGastroparesis / Opioids Use1
2Not Yet RecruitingTreatmentNoise Induced Hearing Loss1
2Not Yet RecruitingTreatmentPlatelet Dysfunction Due to Drugs1
2Not Yet RecruitingTreatmentST Segment Elevation Myocardial Infarction (STEMI)1
2RecruitingPreventionEpilepsies / Sudden unexplained death in epilepsy1
2RecruitingPreventionHeadache Disorders / Migraine Disorders1
2RecruitingPreventionInfections, Pneumococcal1
2RecruitingPreventionIntraoperative Bleeding1
2RecruitingPreventionPostoperative pain1
2RecruitingPreventionUrinary Retention1
2RecruitingTreatmentAdenocarcinomas1
2RecruitingTreatmentAlcohol Use1
2RecruitingTreatmentAntiphospholipid Syndrome (APS)1
2RecruitingTreatmentAssisted Reproductive Technology therapy / Intracytoplsmic Sperm Injection / Recurrent Implantation Failure (RIF)1
2RecruitingTreatmentAutism Spectrum Conditions/Disorders / Autistic Disorder / Childhood Developmental Disorders, Pervasive / Neurodevelopmental Disorders1
2RecruitingTreatmentBile Leak / Common Bile Duct Gall Stones / Infection NOS1
2RecruitingTreatmentCardiovascular Risk Factors / Cognitive Function 1, Social / Poor Glycemic Control1
2RecruitingTreatmentCell Transplantation1
2RecruitingTreatmentChronic Antibody-mediated Transplant Rejection1
2RecruitingTreatmentEssential Thrombocythemia (ET) / Polycythemia Vera (PV)1
2RecruitingTreatmentGlioblastomas / Gliosarcoma1
2RecruitingTreatmentHeart Failure With Normal Ejection Fraction1
2RecruitingTreatmentHeart Failure, Unspecified1
2RecruitingTreatmentHerpetic Gingivostomatitis1
2RecruitingTreatmentPseudomonas Aeruginosa Pneumonia1
2RecruitingTreatmentShock, Septic1
2RecruitingTreatmentSpinal Cord Injuries (SCI)2
2RecruitingTreatmentTinea Pedis1
2RecruitingTreatmentVenous Thromboembolism (VTE) / Wounds and Injuries1
2SuspendedPreventionLung Transplant Recipients1
2TerminatedTreatmentCancer, Breast / Cardiotoxicity / Heart Diseases / Myocardial Dysfunction1
2TerminatedTreatmentCarcinoma, Colorectal1
2TerminatedTreatmentImplants1
2TerminatedTreatmentPsoriasis Vulgaris (Plaque Psoriasis)1
2Unknown StatusPreventionOsteonecrosis1
2Unknown StatusTreatmentBacterial Infection Due to Helicobacter Pylori (H. Pylori)1
2Unknown StatusTreatmentCalcifications, Vascular1
2Unknown StatusTreatmentDental Pulp Necrosis1
2Unknown StatusTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
2Unknown StatusTreatmentNausea / Pain / Pruritus / Vertigo1
2Unknown StatusTreatmentNewborn Infants1
2Unknown StatusTreatmentOptic Neuritis1
2Unknown StatusTreatmentRadiculopathy, Cervical1
2Unknown StatusTreatmentTransient Tachypnea of the Newborn1
2WithdrawnTreatmentAcidosis, Respiratory / Shock, Hemorrhagic / Traumas1
2WithdrawnTreatmentPain, Chronic1
2, 3CompletedNot AvailableAmyotrophic Lateral Sclerosis (ALS)1
2, 3CompletedNot AvailableDepression1
2, 3CompletedPreventionPostpartum Hemorrhage1
2, 3CompletedPreventionTransversus Abdominis Plane Block / Transversus Abdominis Plane Block, Pediatric Laparoscopy1
2, 3CompletedTreatmentAnemias1
2, 3CompletedTreatmentAttention Deficit Disorder With Hyperactivity1
2, 3CompletedTreatmentCardiac Failure / Congestive Heart Failure (CHF) / Heart Failure, Unspecified1
2, 3CompletedTreatmentDisseminated Sclerosis1
2, 3CompletedTreatmentHeart Failure, Unspecified / Myocardial Ischemia1
2, 3CompletedTreatmentInfertilities1
2, 3CompletedTreatmentIsolated (Idiopathic) Oligohydramnios1
2, 3CompletedTreatmentMucositis / Transplantation, Bone Marrow1
2, 3CompletedTreatmentMyocardial Infarction1
2, 3CompletedTreatmentPain After Stapled Haemorrhoidopexy1
2, 3CompletedTreatmentPeriodontal Diseases1
2, 3CompletedTreatmentPeriodontitis, Chronic1
2, 3CompletedTreatmentRespiratory Distress Syndrome (RDS)1
2, 3Not Yet RecruitingPreventionAcute Kidney Injury (AKI) / Patent Ductus Arteriosus (PDA)1
2, 3Not Yet RecruitingTreatmentChronic Rhinosinusitis1
2, 3Not Yet RecruitingTreatmentDyslipidemias / Overweight or Obesity1
2, 3Not Yet RecruitingTreatmentHypothyroidism / Neoplasms / Postoperative Complications1
2, 3Not Yet RecruitingTreatmentSepsis / Thrombocytopenias1
2, 3RecruitingPreventionComplications1
2, 3RecruitingPreventionHepatic Failure / Liver Cirrhosis1
2, 3RecruitingTreatmentAcute Myocardial Infarction: Rehabilitation Phase / Hypogonadism1
2, 3RecruitingTreatmentAplastic Anaemia (AA)1
2, 3RecruitingTreatmentGastroenteritis1
2, 3RecruitingTreatmentGrowth Hormone Treatment / Minor burns1
2, 3RecruitingTreatmentPostoperative pain1
2, 3RecruitingTreatmentUrinary Bladder, Overactive1
2, 3RecruitingTreatmentMinor burns4
2, 3TerminatedTreatmentDrug withdrawal syndrome neonatal1
2, 3TerminatedTreatmentHeart Failure, Unspecified1
2, 3Unknown StatusTreatmentBeta-Thalassemia / Transplantation, Bone Marrow1
2, 3Unknown StatusTreatmentHypertension,Essential2
2, 3Unknown StatusTreatmentSepsis / Thrombocytopenias1
2, 3WithdrawnTreatmentAsthma Bronchial1
2, 3WithdrawnTreatmentHAART-treated / Human Immunodeficiency Virus (HIV) Infections / Virologically Controlled1
2, 3WithdrawnTreatmentPain Perception / Phlebotomy1
3Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Myelogenous Leukaemia (AML) / Hodgkins Disease (HD) / Non-Hodgkin's Lymphoma (NHL)1
3Active Not RecruitingTreatmentBicuspid Aortic Valve (BAV)1
3Active Not RecruitingTreatmentBrachial Plexus Block / Postoperative pain1
3Active Not RecruitingTreatmentMacular Edema (ME) / Retinal Vein Occlusions(RVO)1
3Active Not RecruitingTreatmentMetastatic Colorectal Cancers1
3Active Not RecruitingTreatmentRelapsing Remitting Multiple Sclerosis (RRMS)1
3CompletedPreventionAcute Otitis Media / Infections, Pneumococcal / Secretory Otitis Media / Tympanic Membrane Perforation1
3CompletedPreventionAcute Renal Failure (ARF)1
3CompletedPreventionCancer, Breast / Cardiotoxicity / Heart Failure, Unspecified1
3CompletedPreventionCentral Line-Associated Bloodstream Infection1
3CompletedPreventionChronic Allograft Nephropathy (CAN)1
3CompletedPreventionColorectal Cancers / Malignant Neoplasm of Stomach1
3CompletedPreventionDiphtheria / Meningitis, Bacterial / Pertussis / Poliomyelitis / Tetanus1
3CompletedPreventionDisruption or Dehiscence of Closure of Sternum or Sternotomy1
3CompletedPreventionHCV Coinfection / Human Immunodeficiency Virus (HIV) Infections1
3CompletedPreventionMeningococcal Meningitis1
3CompletedPreventionN. Meningitidis Carriage1
3CompletedPreventionNecrotizing Enterocolitis / Very Low Birth Weight Infants1
3CompletedPreventionOther and unspecified effects of high altitude1
3CompletedPreventionPlasmodium Infections / Pregnancy / Premature Births / Sexually Transmitted Disease (STD)1
3CompletedPreventionProstate Cancer1
3CompletedPreventionRestenosis1
3CompletedPreventionProphylaxis of acute chemotherapy induced nausea and vomiting1
3CompletedTreatmentAcute Agitation / Anaesthesia therapy / Pediatrics1
3CompletedTreatmentAcute Calculous Cholecystitis1
3CompletedTreatmentAcute Nonlymphocytic Leukemia / Leukemia Acute Myeloid Leukemia (AML) / Leukemias1
3CompletedTreatmentAcute Otitis Externa / Swimmer's Ear1
3CompletedTreatmentAcute Urticaria1
3CompletedTreatmentArterial Hypotension / Transient ischemia attacks2
3CompletedTreatmentBMI >30 kg/m21
3CompletedTreatmentBilateral Nasolabial Fold Wrinkles1
3CompletedTreatmentBronchiectasis1
3CompletedTreatmentChronic Urticaria1
3CompletedTreatmentDiminished Ovarian Reserve (DOR) / Infertilities / Ovarian Aging / Predicted Poor-responders1
3CompletedTreatmentDyslipidemias1
3CompletedTreatmentEndometrial Disorder1
3CompletedTreatmentFriedreich's Ataxia1
3CompletedTreatmentGlenohumeral Osteoarthritis1
3CompletedTreatmentHeart Failure, Unspecified1
3CompletedTreatmentHigh Blood Pressure (Hypertension)1
3CompletedTreatmentInfant, Small for Gestational Age1
3CompletedTreatmentIntervertebral Disc Disease / Lumbar Disc Disease1
3CompletedTreatmentIntramural Fibroids / Uterine Leiomyomas1
3CompletedTreatmentKidney, Polycystic1
3CompletedTreatmentLaparoscopic Cholecystectomy1
3CompletedTreatmentMenopausal Hot Flushes / Vasomotor Symptoms1
3CompletedTreatmentMyocardial Infarction1
3CompletedTreatmentPain1
3CompletedTreatmentPain Associated With Fibromyalgia1
3CompletedTreatmentPatients With Moderate-to-severe COPD With Destroyed Lung by Tuberculosis1
3CompletedTreatmentPostoperative pain1
3CompletedTreatmentTransplant, Kidney1
3CompletedTreatmentVasoplegic Syndrome1
3CompletedTreatmentWomen With Recurrent Implantation Failure (Three Previous IVF Attempts Failed and at Least 8 Good Embryos Replaced1
3CompletedTreatmentMinor burns1
3Enrolling by InvitationTreatmentCancers1
3Enrolling by InvitationTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)2
3Not Yet RecruitingPreventionFemoral Head Necrosis / Osteoarthritis (OA) / Rheumatoid Arthritis1
3Not Yet RecruitingPreventionNon-DM Stage III Colorectal Cancer1
3Not Yet RecruitingTreatmentBariatric Surgery Candidate / Obesity, Morbid1
3Not Yet RecruitingTreatmentIntracerebral Hemorrhage1
3Not Yet RecruitingTreatmentRecurrent Vulvovaginal Candidiasis1
3Not Yet RecruitingTreatmentRespiratory Distress Syndrome, Adult1
3Not Yet RecruitingTreatmentShockable Out of Hospital Cardiac Arrest1
3Not Yet RecruitingTreatmentTransplantation, Lung1
3Not Yet RecruitingTreatmentUlcerative Colitis (UC)1
3RecruitingHealth Services ResearchBreast Cancer Patients1
3RecruitingTreatmentAcute Urticaria1
3RecruitingTreatmentAlcohol Withdrawal Syndrome(AWS)1
3RecruitingTreatmentAnaesthesia therapy / Opioid-Related Disorders1
3RecruitingTreatmentAnaplastic Gliomas With 1p/19q Codeletion1
3RecruitingTreatmentCancer, Breast1
3RecruitingTreatmentCardiopulmonary Bypass / Defect, Congenital Heart / Surgery, Cardiac1
3RecruitingTreatmentCervical Myelopathy1
3RecruitingTreatmentChagas Disease1
3RecruitingTreatmentCoronary Heart Disease (CHD)1
3RecruitingTreatmentDiabetic Foot Ulcers (DFU)1
3RecruitingTreatmentFoot Ulcer, Diabetic1
3RecruitingTreatmentHER2 Positive Breast Cancers / Stage I Breast Carcinoma1
3RecruitingTreatmentHeart Failure, Unspecified1
3RecruitingTreatmentIntraventricular Hemorrhage of Prematurity1
3RecruitingTreatmentKnee Replacement Surgery / Pain Management1
3RecruitingTreatmentMacular Edema (ME) / Retinal Vein Occlusions(RVO)1
3RecruitingTreatmentMajor Depressive Disorder (MDD)1
3RecruitingTreatmentMultiple Myeloma (MM)1
3RecruitingTreatmentNoonan Syndrome1
3RecruitingTreatmentPain1
3RecruitingTreatmentPlatelet Aggregation During Acute Myocardial Infarction1
3RecruitingTreatmentProstate Cancer1
3RecruitingTreatmentRecurrent Vulvovaginal Candidiasis1
3RecruitingTreatmentRecurrent or Metastatic, Platinum-refractory Cervical Cancer1
3RecruitingTreatmentTuberculosis1
3RecruitingTreatmentType 2 Diabetes Mellitus1
3SuspendedTreatmentSymptomatic Superficial Vein Thrombosis1
3TerminatedSupportive CareNarcotic Use / Pregnancy Related1
3TerminatedTreatmentAcute Rejection1
3TerminatedTreatmentCancers1
3TerminatedTreatmentCroup1
3TerminatedTreatmentInfluenza in Humans / Viral Pneumonia1
3TerminatedTreatmentMajor Depression With Psychotic Features / Psychosis / Psychotic Depression / Severe Major Depression With Psychotic Features1
3TerminatedTreatmentNeuropathy1
3TerminatedTreatmentOtospongiosis1
3TerminatedTreatmentRheumatoid Arthritis1
3Unknown StatusPreventionNecrotizing Enterocolitis / Very Low Birth Weight Infants1
3Unknown StatusTreatmentAcne Vulgaris1
3Unknown StatusTreatmentInfertilities1
3Unknown StatusTreatmentKnee Injuries / Knee Pain Chronic1
3Unknown StatusTreatmentMenopause1
3Unknown StatusTreatmentRetained Hemothorax1
3Unknown StatusTreatmentType 2 Diabetes Mellitus1
3WithdrawnPreventionPlacenta Accreta1
3WithdrawnTreatmentColorectal Disorders / Observation of Neuromuscular Block1
3WithdrawnTreatmentLuteal Phase Defect1
4Active Not RecruitingPreventionInsecticide Resistance1
4Active Not RecruitingSupportive CareIntervertebral Disc Degeneration1
4Active Not RecruitingSupportive CareRetinal Detachment1
4CompletedNot AvailableInflammatory Reaction1
4CompletedNot AvailablePrecedex Effect to Propofol Requirement1
4CompletedBasic ScienceLow Back Pain (LBP)1
4CompletedBasic SciencePeripheral Arterial Disease (PAD)1
4CompletedOtherIntubation Complications1
4CompletedOtherSurgical Preparation of the Vagina1
4CompletedPreventionAcute Agitation / Delirium1
4CompletedPreventionBMI >30 kg/m21
4CompletedPreventionEmergence Agitation1
4CompletedPreventionEsophageal Strictures1
4CompletedPreventionFevers / Pneumonia1
4CompletedPreventionFlu caused by Influenza1
4CompletedPreventionLiver Cancer / Liver Cirrhosis1
4CompletedPreventionParatyphoid Fever / Salmonella Typhi Infection2
4CompletedPreventionPostoperative Inflammatory Response1
4CompletedPreventionPostpartum Endometritis1
4CompletedPreventionPostreperfusion Syndrome / Transplantation, Liver1
4CompletedPreventionSpinal Anesthetics Causing Adverse Effects in Therapeutic Use1
4CompletedSupportive CareCaudal Block1
4CompletedSupportive CarePain1
4CompletedSupportive CarePost-Operative Pain1
4CompletedSupportive CareRectal Carcinoma1
4CompletedTreatmentAnaesthesia therapy1
4CompletedTreatmentAnesthetics, Local1
4CompletedTreatmentAneurysmal Subarachnoid Hemorrhage1
4CompletedTreatmentAnterior Cruciate Ligament Reconstruction / Regional Anesthesia, Saphenous Nerve Block1
4CompletedTreatmentBacterial Infection Due to Helicobacter Pylori (H. Pylori)1
4CompletedTreatmentBariatric Surgery Candidate / Postoperative pain1
4CompletedTreatmentBipolar Disorder (BD) / Mania1
4CompletedTreatmentBlood Loss,Surgical / Hip Replacement Surgery / Tranexamic Acid Adverse Reaction1
4CompletedTreatmentCHROMOSOME 2q31.2 DELETION SYNDROME / Ehlers-danlos syndrome, type IV, autosomal dominant1
4CompletedTreatmentCardiopulmonary Bypass / Surgery, Cardiac1
4CompletedTreatmentCardiovascular Disease (CVD)1
4CompletedTreatmentCardiovascular Outcomes1
4CompletedTreatmentCleft Palates / Hemorrhage1
4CompletedTreatmentCoronary Artery Disease2
4CompletedTreatmentDiabetes Mellitus (DM)1
4CompletedTreatmentDiabetes Mellitus (DM) / Heart Failure, Unspecified1
4CompletedTreatmentEndometriosis / Infertilities / Ovarian Cysts1
4CompletedTreatmentEpilepsy, Localization Related1
4CompletedTreatmentFibrosis / Glaucoma / Optic Neuropathies1
4CompletedTreatmentHypermenorrhea1
4CompletedTreatmentHyperparathyroidism, Secondary1
4CompletedTreatmentHypothermia1
4CompletedTreatmentInfection NOS1
4CompletedTreatmentInfertilities1
4CompletedTreatmentInjections, Spinal / Morphine / Patients Satisfaction / Prostatectomy1
4CompletedTreatmentInsulin Resistance / Metabolic Syndromes / Schizophrenic Disorders1
4CompletedTreatmentAdjunct to general anesthesia therapy / Intravenous Anesthesia1
4CompletedTreatmentKnee Osteoarthritis (Knee OA)1
4CompletedTreatmentMemory1
4CompletedTreatmentMyofascial Pain Syndrome / Temporomandibular Disorders1
4CompletedTreatmentNonvalvular Atrial Fibrillation1
4CompletedTreatmentObstructive Sleep Apnea (OSA)1
4CompletedTreatmentOpioid Induced Constipation (OIC)1
4CompletedTreatmentPeriodontal Diseases / Type 2 Diabetes Mellitus1
4CompletedTreatmentPeriodontitis1
4CompletedTreatmentPeripheral Arterial Disease (PAD)2
4CompletedTreatmentPeritoneal Dialysis Associated Peritonitis1
4CompletedTreatmentPostoperative Pain Following Knee Arthroplasty1
4CompletedTreatmentPostoperative pain1
4CompletedTreatmentPregnancy Related / Tobacco Use Disorders1
4CompletedTreatmentRelieve of Ureteral Stent Symptoms1
4CompletedTreatmentRenal Transplant Candidate for Right Kidney1
4CompletedTreatmentSleep Deprivation1
4CompletedTreatmentTolerance1
4CompletedTreatmentTooth; Lesion, White Spot Lesions1
4CompletedTreatmentTotal Knee Arthroplasty (TKA)1
4CompletedTreatmentUrge Urinary Incontinence / Urinary Bladder, Overactive1
4Enrolling by InvitationPreventionBifidobacteri / Colon Polyps / Combizym1
4Enrolling by InvitationPreventionEmergence Agitation / Pain1
4Not Yet RecruitingPreventionAcute Kidney Injury (AKI) / Cardiac Valve Disease / Oxygen Radical Damage / Post-Op Complication / Surgery--Complications1
4Not Yet RecruitingPreventionAnaesthesia therapy1
4Not Yet RecruitingPreventionHerpes Simplex Virus Keratitis1
4Not Yet RecruitingPreventionInfluenza Vaccines / Transplantations1
4Not Yet RecruitingPreventionIntestinal Recovery After Cesarean Section1
4Not Yet RecruitingPreventionThroat Pain1
4Not Yet RecruitingSupportive CareHematoma Postoperative1
4Not Yet RecruitingTreatmentAtherosclerosis Type 2 Diabetes Mellitus Dipeptidyl Peptidase-4 Inhibitor GLP-11
4Not Yet RecruitingTreatmentBMI >30 kg/m21
4Not Yet RecruitingTreatmentBack Pain With Radiation / Low Back Pain (LBP) / Radicular; Neuropathic, Lumbar, Lumbosacral1
4Not Yet RecruitingTreatmentChronic Pain Syndrome / Opioids Use / Postpartum disorder1
4Not Yet RecruitingTreatmentDeep Vein Thrombosis (DVT) / Myocardial Infarction / Pulmonary Embolism (PE) / Safety / Strokes1
4Not Yet RecruitingTreatmentDegenerative Intervertebral Discs / Low Back Pain (LBP) / Sciatic Radiculopathy1
4Not Yet RecruitingTreatmentFemoroacetabular Impingement1
4Not Yet RecruitingTreatmentImpaired Glucose Tolerance (IGT) / Polycystic Ovarian Syndrome1
4Not Yet RecruitingTreatmentInfection caused by staphylococci / Streptococcal Infections1
4Not Yet RecruitingTreatmentPostoperative pain1
4Not Yet RecruitingTreatmentType 2 Diabetes Mellitus1
4Not Yet RecruitingTreatmentChronic heart failure with reduced ejection fraction (NYHA Class IV)1
4RecruitingBasic ScienceHepatic Glucose Metabolism1
4RecruitingDiagnosticDisseminated Sclerosis1
4RecruitingHealth Services ResearchDiabetes Mellitus (DM)1
4RecruitingOtherBMI >30 kg/m2 / Cardiovascular Physiological Phenomena / Metabolism1
4RecruitingPreventionAcute Kidney Injury (AKI)1
4RecruitingPreventionAntibiotic Prophylaxis / Tuberculosis, Pulmonary1
4RecruitingPreventionArterial Hypotension1
4RecruitingPreventionLower Extremity Surgical Amputation / Post-amputation Functioning / Post-amputation Opioid Requirements / Post-Amputation Phantom Limb Pain1
4RecruitingPreventionPain in Pediatric Patients1
4RecruitingPreventionPeritoneal dialysis therapy1
4RecruitingPreventionPortal Vein Tumor Thrombus1
4RecruitingPreventionPostoperative Acute Kidney Injury in Patients Undergoing Aortic Surgery1
4RecruitingPreventionPostoperative pain1
4RecruitingPreventionProphylaxis against postoperative nausea and vomiting1
4RecruitingSupportive CareCoronary Artery Disease1
4RecruitingSupportive CareRotator Cuff Syndrome1
4RecruitingTreatmentAdiposity1
4RecruitingTreatmentBariatric Surgery Candidate / Postoperative pain1
4RecruitingTreatmentBleed Pregnancy / Blood Loss,Surgical / Cesarean Section Complications / Postpartum Hemorrhage / Pregnancy Related1
4RecruitingTreatmentChronic Obstructive Pulmonary Disease (COPD)1
4RecruitingTreatmentChronic Obstructive Pulmonary Disease (COPD) / Hypercarbia1
4RecruitingTreatmentCoronary Artery Disease1
4RecruitingTreatmentDentin Hypersensitivity1
4RecruitingTreatmentDepression1
4RecruitingTreatmentHeart Failure, Unspecified / Sleep Disturbances1
4RecruitingTreatmentHemorrhage Esophageal / Liver Cirrhosis / Portal Hypertension / Varicose Veins Esophagus1
4RecruitingTreatmentHepatitis B Chronic Infection1
4RecruitingTreatmentIdiopathic angioedema1
4RecruitingTreatmentIntravenous Drug Usage / Iron-Deficiency Anemias / Neoplasms, Colorectal / Surgery, Colorectal1
4RecruitingTreatmentLocal Anesthesia1
4RecruitingTreatmentLocal Anesthesia / Postoperative pain1
4RecruitingTreatmentLumbar Disc Disease / Lumbar Radiculopathy / Prolapsed Lumbar Disc1
4RecruitingTreatmentNon-ST-elevation Acute Coronary Syndromes / Non-ST-Elevation Myocardial Infarction / Unstable Angina (UA)1
4RecruitingTreatmentOpioids Use1
4RecruitingTreatmentOpioids Use / Postoperative pain1
4RecruitingTreatmentPain1
4RecruitingTreatmentPain, Acute / Rib Fracture Multiple / Trauma Chest1
4RecruitingTreatmentPeripheral Artery Disease (PAD)1
4RecruitingTreatmentPost-operative Pain Management1
4RecruitingTreatmentPulmonary Disease, Chronic Obstructive1
4RecruitingTreatmentRib Fracture Multiple / Rib Fractures1
4RecruitingTreatmentUlcerative Colitis (UC)1
4TerminatedNot AvailableDyslipidemias1
4TerminatedTreatmentAdverse Reaction to Drug / Obstructive Sleep Apnea (OSA) / Recurrent Tonsillitis / Sleep Disordered Breathing (SDB)1
4TerminatedTreatmentAlcohol Dependence1
4TerminatedTreatmentBipolar Disorder (BD) / Generalized Anxiety Disorder (GAD)1
4TerminatedTreatmentICU Patients1
4TerminatedTreatmentOver-Active Bladder1
4TerminatedTreatmentShock, Septic1
4Unknown StatusNot AvailableTransplant, Kidney1
4Unknown StatusPreventionContinuous ambulatory peritoneal dialysis therapy1
4Unknown StatusPreventionInfertilities / Polycystic Ovarian Syndrome1
4Unknown StatusSupportive CarePatient Satisfaction for Bronchoscopy1
4Unknown StatusTreatmentAcquired Immune Deficiency Syndrome (AIDS) / Human Immunodeficiency Virus (HIV) Infections1
4Unknown StatusTreatmentAcute Coronary Syndromes (ACS) / Smoking1
4Unknown StatusTreatmentAllergic Rhinitis (AR)1
4Unknown StatusTreatmentCatocholamine Induced Finger Necrosis1
4Unknown StatusTreatmentCervical Ripening1
4Unknown StatusTreatmentChronic Hepatitis B, Gestation1
4Unknown StatusTreatmentChronic Pelvic Pain / Endometriosis1
4Unknown StatusTreatmentHigh Heart Rate1
4Unknown StatusTreatmentInfluenza A Virus Infection1
4Unknown StatusTreatmentKnee Replacement Surgery1
4Unknown StatusTreatmentLaryngoscopy / Preanesthetic Medication1
4Unknown StatusTreatmentNonulcer Dyspepsia1
4Unknown StatusTreatmentPeritoneal Membrane Failure1
4Unknown StatusTreatmentSmoking1
4Unknown StatusTreatmentTotal Hip Arthroplasty (THA)1
Not AvailableActive Not RecruitingBasic ScienceMetabolic Diseases1
Not AvailableActive Not RecruitingDevice FeasibilityPostoperative pain1
Not AvailableActive Not RecruitingTreatmentChronic Heart Failure (CHF)1
Not AvailableActive Not RecruitingTreatmentParenteral Nutrition1
Not AvailableActive Not RecruitingTreatmentPsoriasis1
Not AvailableCompletedNot AvailableAnaphylactic Shock to Curare / Anaphylactic Shock to Neuro-Muscular Blocking Agents (NMBA)1
Not AvailableCompletedNot AvailableContraceptive Behavior / Opiate Addiction / Pregnancy / Sexual Behavior1
Not AvailableCompletedNot AvailableHealthy Volunteers2
Not AvailableCompletedNot AvailableInfection, Postoperative Wound1
Not AvailableCompletedNot AvailableJaundice, Obstructive / Surgical Procedure, Unspecified1
Not AvailableCompletedNot AvailableLaryngospasm1
Not AvailableCompletedNot AvailableSepsis1
Not AvailableCompletedNot AvailableSunscreen Agents3
Not AvailableCompletedNot AvailableSunscreening Agents1
Not AvailableCompletedBasic ScienceBrain Metabolism / Ketone Body Metabolism1
Not AvailableCompletedBasic ScienceExtra-pancreatic Incretin Effect / Glucose Effectiveness1
Not AvailableCompletedBasic ScienceInflammatory Responses1
Not AvailableCompletedBasic SciencePancreatic Fistula1
Not AvailableCompletedDiagnosticAcute Coagulopathy1
Not AvailableCompletedDiagnosticCongenital Heart Disease (CHD) / Sedated for Cardiac Catheterization1
Not AvailableCompletedDiagnosticRespiratory Insufficiency1
Not AvailableCompletedHealth Services ResearchBMI >30 kg/m21
Not AvailableCompletedPreventionAcute Kidney Injury (AKI)1
Not AvailableCompletedPreventionAirway Extubation1
Not AvailableCompletedPreventionAnesthesia Intubation Complications / Tracheal Disease1
Not AvailableCompletedPreventionArterial Hypotension / Coronary Artery Bypass Graft Triple Vessel1
Not AvailableCompletedPreventionCatheter-Related Infections1
Not AvailableCompletedPreventionColorectal Cancers1
Not AvailableCompletedPreventionCoughing Responses at Tracheal Extubation1
Not AvailableCompletedPreventionCraniosynostosis Patients Undergoing Distraction Osteotomy1
Not AvailableCompletedPreventionHypotension After Reperfusion in Liver Transplantation1
Not AvailableCompletedPreventionNeoplasms, Breast1
Not AvailableCompletedPreventionPain Control1
Not AvailableCompletedPreventionAdjunct to general anesthesia therapy / Palonosetron1
Not AvailableCompletedPreventionProphylaxis against postoperative nausea and vomiting2
Not AvailableCompletedPreventionResidual Neuromuscular Blockade1
Not AvailableCompletedPreventionSeroma1
Not AvailableCompletedPreventionStomach Neoplasms1
Not AvailableCompletedPreventionTransplantation, Kidney1
Not AvailableCompletedSupportive CareChronic Rhinosinusitis1
Not AvailableCompletedTreatmentAcne, Photodynamic Therapy1
Not AvailableCompletedTreatmentAcute Myocardial Infarction (AMI)1
Not AvailableCompletedTreatmentAsthma Bronchial1
Not AvailableCompletedTreatmentAtherosclerosis1
Not AvailableCompletedTreatmentBody Temperature Changes1
Not AvailableCompletedTreatmentBreastfeeding / Relaxation Therapy / Stress, Psychological / Stress-related Problems1
Not AvailableCompletedTreatmentCervical Pain1
Not AvailableCompletedTreatmentDepression / Feeling Anxious1
Not AvailableCompletedTreatmentDiabetes Mellitus (DM) / Hyperglycemias / Transplantation, Kidney1
Not AvailableCompletedTreatmentDrug Usage1
Not AvailableCompletedTreatmentEye Dryness1
Not AvailableCompletedTreatmentFertilization in Vitro / Infertilities / Recurrent Implantation Failure (RIF)1
Not AvailableCompletedTreatmentICU Anemia / Traumas1
Not AvailableCompletedTreatmentInflammatory Reaction After Neonatal Cardiac Surgery / Ischemia/Reperfusion Injury After Neonatal Cardiac Surgery1
Not AvailableCompletedTreatmentAdjunct to general anesthesia therapy / Laparoscopic Cholecystectomy1
Not AvailableCompletedTreatmentMalaria Anaemia1
Not AvailableCompletedTreatmentMelanoma / Sarcomas1
Not AvailableCompletedTreatmentNeoplasms, Esophageal1
Not AvailableCompletedTreatmentPregnancy2
Not AvailableCompletedTreatmentProliferative Diabetic Retinopathy (PDR)1
Not AvailableCompletedTreatmentRenal Function Disorder1
Not AvailableCompletedTreatmentShock, Septic1
Not AvailableNo Longer AvailableNot AvailableDiabetes, Diabetes Mellitus Type 11
Not AvailableNot Yet RecruitingPreventionPost-ERCP Acute Pancreatitis1
Not AvailableNot Yet RecruitingTreatmentIntervertebral Disc Displacement / Spinal Stenosis1
Not AvailableNot Yet RecruitingTreatmentLidocaine / Pain, Chronic / Postoperative pain / Thoracic Surgery, Video-Assisted1
Not AvailableNot Yet RecruitingTreatmentPain, Chronic / Vulvodynia1
Not AvailableNot Yet RecruitingTreatmentRadiation Induced Oral Mucositis1
Not AvailableNot Yet RecruitingTreatmentTonsillectomy1
Not AvailableRecruitingNot AvailableHip Fractures1
Not AvailableRecruitingBasic ScienceHyperthermia / Muscle Force1
Not AvailableRecruitingDiagnosticBlood Coagulation Tests ( INR, APTT)1
Not AvailableRecruitingDiagnosticCystic Fibrosis (CF)1
Not AvailableRecruitingDiagnosticIrritable Bowel Syndrome (IBS)1
Not AvailableRecruitingOtherPostoperative pain1
Not AvailableRecruitingPreventionCardiopulmonary Bypass / Thoracic Surgery1
Not AvailableRecruitingPreventionDelirium1
Not AvailableRecruitingPreventionHysteroscopy1
Not AvailableRecruitingPreventionStrokes1
Not AvailableRecruitingPreventionTransplantation, Kidney1
Not AvailableRecruitingPreventionVentral Hernias1
Not AvailableRecruitingSupportive CareBreast Neoplasm Malignant Primary1
Not AvailableRecruitingSupportive CareHeart Valve Diseases1
Not AvailableRecruitingSupportive CareHyperparathyroidism, Secondary1
Not AvailableRecruitingSupportive CareLiver Function Post BCAA Infusion1
Not AvailableRecruitingSupportive CareSpine Surgery1
Not AvailableRecruitingTreatmentAnaesthesia therapy / Post-Operative Pain1
Not AvailableRecruitingTreatmentBiliary Stasis, Extrahepatic1
Not AvailableRecruitingTreatmentCardiac Surgical Procedures1
Not AvailableRecruitingTreatmentComplex Valvular Heart Surgery1
Not AvailableRecruitingTreatmentCongestive Cardiomyopathy1
Not AvailableRecruitingTreatmentDental Fear1
Not AvailableRecruitingTreatmentHypogonadism / Non Obstructive Azoospermia1
Not AvailableRecruitingTreatmentLigament Injury / Nerve Entrapment / Osteoarthritis (OA) / Rheumatoid Arthritis1
Not AvailableRecruitingTreatmentPeriampullary Tumors1
Not AvailableRecruitingTreatmentTuberculosis, Pulmonary / Type 2 Diabetes Mellitus1
Not AvailableRecruitingTreatmentMinor burns1
Not AvailableTerminatedPreventionEndoscopic Retrograde Cholangiopancreatography / Pancreatitis1
Not AvailableTerminatedPreventionExternal Causes of Morbidity and Mortality / Hospital Acquired Infections / Hypoglycemia1
Not AvailableTerminatedTreatmentHemostasis1
Not AvailableTerminatedTreatmentSpastic Cerebral Palsy1
Not AvailableUnknown StatusNot AvailableHaemorrhage / Venous Thromboembolism (VTE)1
Not AvailableUnknown StatusPreventionAcute Renal Failure (ARF) / Oxidative Stress Induction1
Not AvailableUnknown StatusPreventionIntravenous Injections1
Not AvailableUnknown StatusPreventionOrthognathic Surgery / Pain1
Not AvailableUnknown StatusPreventionThroat Pain1
Not AvailableUnknown StatusPreventionTransplantation, Renal1
Not AvailableUnknown StatusSupportive CareCellulitis1
Not AvailableUnknown StatusSupportive CareOverweight and Obesity1
Not AvailableUnknown StatusSupportive CarePain1
Not AvailableUnknown StatusTreatmentAcure Respiratory Distress Syndrome (ARDS) / Acute Lung Injury (ALI) / Sepsis1
Not AvailableUnknown StatusTreatmentAcute Myocardial Infarction (AMI)1
Not AvailableUnknown StatusTreatmentAcute Respiratory Distress Syndrome (ARDS) / Blunt Chest Trauma1
Not AvailableUnknown StatusTreatmentAsthma Bronchial1
Not AvailableUnknown StatusTreatmentClosure of the Skin After Liver Resection1
Not AvailableUnknown StatusTreatmentCoronary Artery Disease1
Not AvailableUnknown StatusTreatmentFlexion Contracture Following Total Knee Replacement1
Not AvailableUnknown StatusTreatmentHypophosphatemia / Transplant, Kidney1
Not AvailableUnknown StatusTreatmentMultimodal Analgesia / Postoperative Pain Control1
Not AvailableWithdrawnSupportive CareIntracranial Pressure Increase1
Not AvailableWithdrawnTreatmentDiabetic Neuropathies1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
JellyTopical
SoapTopical1 g/100mL
LiquidTopical2.1 mL/100mL
LiquidTopical1.49 %
LotionTopical1.0 %
SoapTopical0.005 mL/1mL
SoapTopical250 g/1000mL
SolutionTopical1.5 g/100mL
LiquidTopical.3 mg/1mL
LiquidTopical0.5 %
LiquidTopical6.046 g/1L
SoapTopical40 g/1kg
SoapTopical.3 g/100g
SoapTopical5 mL/1000mL
GelTopical1.0 %
SoapTopical2.5 mg/1mL
SoapTopical6.10 g/1L
SoapTopical4 g/1000mL
GelTopical10 mg/1mL
SoapTopical0.25 mg/100mL
GelTopical4 mL/800mL
LotionTopical3.6 mL/800mL
SoapTopical6.0 mg/1000mL
Liquid; soapTopical.6 %
SoapTopical0.45 g/100mL
LotionTopical0.6 %
OintmentTopical1.5 mg
LiquidTopical0.5 g/100mL
SoapTopical0.3 mg/100mL
SoapTopical25 g/100g
OintmentTopical8 mg
SolutionTopical30 mg/1mL
SolutionTopical3.0 %
CreamTopical.25 %
SoapTopical15 g/1L
LiquidTopical3.09 mg/1mL
LiquidTopical5 mg/100mL
SolutionTopical0.6 mg/100mL
SoapTopical10.1 mg/1mL
SoapTopical5 mg/1mL
SoapTopical0.003 g/1mL
LiquidTopical5 %
Kit
ShampooTopical
LiquidTopical4 mg/1mL
Lotion; soapTopical.5 %
LiquidTopical0.95 mL/100mL
SoapTopical0.002 g/1mL
LiquidTopical.6 %
LiquidTopical4.8 %
LiquidTopical10 %
SolutionTopical4.8 g/100mL
SolutionTopical0.6 mL/100mL
LiquidTopical3.09 1/1mL
LiquidTopical0.15 g/100mL
SpongeTopical3 %
LiquidTopical1.1 %
SolutionTopical0.9 mg/100mL
SolutionTopical1.0 mg/100mL
SolutionTopical100 mg/1mL
SolutionTopical5.20 mg/1mL
SolutionTopical5 mg/1mL
SoapTopical4 mg/1mL
LiquidTopical10 mg/1mL
SolutionTopical0.8 mg/100mL
LotionTopical0.25 %
SolutionTopical8 mg/1mL
Lotion; soapTopical0.8 %
LiquidTopical15.75 g/1000mL
LiquidTopical
LiquidTopical2.5 mg/1mL
LiquidTopical7.5 mg/1mL
SoapTopical2.5 g/1000mL
SolutionTopical0.50 %
SoapTopical2 g/100L
SolutionTopical10 mg/1mL
Aerosol, foamTopical
LotionTopical.5 %
SoapTopical2.5 mg/0.001L
SolutionTopical0.3 g/100mL
SolutionTopical3.3 g/100g
LiquidTopical0.50 %
LiquidTopical0.663 g/221mL
LiquidTopical0.5 g/100g
LiquidTopical3.5 g/100mL
LiquidTopical0.003 mg/1mL
LiquidTopical0.50 g/100mL
LiquidTopical1.50 g/100mL
LotionTopical10.22 g/1000mL
Solution / dropsAuricular (otic)
LiquidTopical; Vaginal
GelTopical5 mg/1mL
SoapTopical3 mg/1mL
SoapTopical3 g/1000mL
SoapTopical0.75 g/100mL
SolutionTopical1.75 %
SolutionTopical17.5 g/1L
SolutionTopical0.0175 L/1L
SolutionTopical0.0175 g/1mL
Aerosol, foamTopical0.005 g/1mL
LiquidTopical10.22 g/1000mL
GelTopical0.05 g/59g
SolutionTopical0.5 mg/100mL
LiquidTopical3 mg/1mL
SoapTopical10.11 g/1L
SoapTopical0.1 g/1L
SoapTopical0.5 mg/100mL
LiquidTopical5 mg/1mL
GelTopical0.95 g/1g
LiquidTopical6 mg/1mL
SoapTopical0.95 mL/100mL
SolutionTopical6.12 mg/1mL
LiquidTopical0.30 g/100g
LiquidTopical0.3 %
SolutionTopical
LotionTopical.25 %
LiquidTopical.5 %
SoapTopical7.5 mg/1mL
LiquidAuricular (otic)
ClothTopical0.5 %
SoapTopical25 g/1000mL
SpongeTopical33 mg/1mL
SpongeTopical40 mg/1mL
SoapTopical0.005 g/1mL
SoapTopical0.1 g/100g
LiquidTopical0.6657 mg/221.8mL
LiquidTopical1.5 %
SolutionTopical0.6 %
LiquidTopical0.525 %
LiquidTopical.25 %
LiquidTopical0.30 kg/100kg
LotionTopical.6 %
SolutionTopical6 mg/1mL
SoapTopical0.3 g/100mL
LiquidTopical0.5 mL/100mL
SolutionTopical5.2 mg/1mL
SolutionTopical5.25 mg/1mL
LotionTopical.3 %
LiquidTopical0.005 mg/1mL
SoapTopical6 mg/1mL
LiquidTopical2.949 g/100mL
LiquidTopical3 mL/100mL
LiquidTopical0.8 mL/100mL
LotionTopical0.08 mg/100mL
OintmentTopical
GelTopical1 %
SoapTopical30 mg/10mL
LiquidTopical.7 %
LiquidTopical5 g/1L
SoapTopical5 g/1000mL
LiquidTopical0.01 mg/1mL
LiquidTopical0.5 mg/100mL
SwabTopical
SoapTopical10 mg/1mL
LiquidTopical0.0060 mg/1mL
LiquidTopical0.0060 g/1mL
CreamTopical
LotionTopical
SolutionTopical0.5 g/100mL
SolutionTopical0.5 %
SolutionTopical1.25 g/100mL
SolutionTopical1.25 %
LiquidTopical1.75 %
SolutionTopical33 mg/1mL
SolutionTopical40 mg/1mL
SolutionTopical3.3 %
SolutionTopical3.3 mg/100mL
SolutionTopical4 mg/100mL
LotionTopical0.5 %
Aerosol, foamTopical.5 mL/100mL
LotionTopical0.3 %
LiquidTopical0.6 mL/100mL
LiquidTopical0.05 g/100mL
Aerosol, foamTopical5 mg/1mL
SoapTopical0.33 mg/1000mL
LiquidTopical1.0 %
AerosolTopical.1 %
SolutionTopical3.82 g/100mL
LiquidTopical0.3 mL/100mL
LiquidTopical1 g/100mL
SolutionTopical1 g/100mL
SolutionTopical10 g/1L
LotionTopical0.51 %
SoapTopical0.001 mg/100mL
LiquidTopical1 %
LiquidTopical12.604 g/100mL
LiquidTopical189 g/1000mL
SoapTopical3 %
LiquidTopical3 %
LiquidCutaneous0.75 g/100mL
GelTopical.25 %
LiquidTopical2 %
SoapTopical
SoapTopical2.75 g/100mL
SolutionTopical2.75 %
LiquidTopical2.75 g/100mL
LiquidTopical0.3 kg/100kg
LotionTopical1 %
LiquidTopical0.3 g/100mL
SoapTopical3.75 mg/1mL
SoapTopical0.75 g/100g
SoapTopical3.6 g/1mL
LiquidTopical3.09 g/1mL
LiquidTopical3.06 mg/1mL
GelTopical
GelTopical0.52 g/100mL
LiquidTopical0.52 %
GelTopical0.5 %
ClothTopical0.5 g/100g
LiquidTopical0.6 %
LiquidTopical0.65 %
SoapTopical1 g/100g
SoapTopical5.0 mg/1mL
LiquidTopical2081980 mg/208198mL
SoapTopical.5 %
LiquidTopical0.03 g/10mL
LiquidTopical0.3 g/10mL
LiquidTopical0.04 g/10mL
LiquidTopical0.04 g/10L
Liquid; shampooTopical
Prices
Not Available
Patents
Not Available

Properties

State
Liquid
Experimental Properties
PropertyValueSource
melting point (°C)112-116 degrees CelsiusMSDS
boiling point (°C)246 degrees CelsiusMSDS
water solubility0.03 g/100ml at 15 degrees Celsius, 0.5 g/100ml at 100 degrees CelsiusMSDS
Predicted Properties
PropertyValueSource
Water Solubility0.855 mg/mLALOGPS
logP3.14ALOGPS
logP3.3ChemAxon
logS-2.3ALOGPS
pKa (Strongest Acidic)9.21ChemAxon
pKa (Strongest Basic)-6.3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area20.23 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity42.93 m3·mol-1ChemAxon
Polarizability16.04 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Mass Spectrum (Electron Ionization)MSsplash10-05fu-9500000000-8bba3165beb98d883986
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable

Taxonomy

Description
This compound belongs to the class of organic compounds known as meta cresols. These are aromatic compounds containing a meta-cresol moiety, which consists of a benzene ring bearing a methyl group and a hydroxyl group at ring positions 1 and 3, respectively.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Phenols
Sub Class
Cresols
Direct Parent
Meta cresols
Alternative Parents
m-Xylenes / P-chlorophenols / Chlorobenzenes / 1-hydroxy-2-unsubstituted benzenoids / Aryl chlorides / Organooxygen compounds / Organochlorides / Hydrocarbon derivatives
Substituents
M-xylene / Xylene / 4-chlorophenol / M-cresol / 4-halophenol / 1-hydroxy-2-unsubstituted benzenoid / Chlorobenzene / Halobenzene / Aryl chloride / Aryl halide
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
phenols, monochlorobenzenes (CHEBI:34393)

Drug created on December 03, 2015 09:51 / Updated on September 18, 2018 23:02