Keratolytic Agents

Agents that soften, separate, and cause desquamation of the cornified epithelium or horny layer of skin. They are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases.
DrugDrug NameDrug Indication
DB00936Salicylic acidKey additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts.
DB06815Pyrithione zincIndicated for the treatment of dandruff and seborrheic dermatitis [A27133].
DB11082Coal tarRelieving itching, irritation, redness, dryness, scaling, and flaking of the skin caused by psoriasis, seborrhea, or eczema.
DB00459AcitretinFor the treatment of severe psoriasis in adults.
DB00755TretinoinFor the the induction of remission in patients with acute promyelocytic leukemia (APL), French-American-British (FAB) classification M3 (including the M3 variant); For the topical treatment of acne vulgaris, flat warts and other skin conditions (psoriasis, ichthyosis congenita, icthyosis vulgaris, lamellar icthyosis, keratosis palmaris et plantaris, epidermolytic hyperkeratosis, senile comedones, senile keratosis, keratosis follicularis (Darier's disease), and basal cell carcinomas.); For palliative therapy to improve fine wrinkling, mottled hyperpigmentation, roughness associated with photodamage.
DB00799TazaroteneUsed to treat psoriasis, acne and sun damaged skin (photodamage).
DB00926EtretinateFor the treatment of severe psoriasis in adults.
DB01179PodofiloxFor treatment of external genital warts (Condyloma acuminatum).
DB03085Glycolic acidNot Available
DB09094Podophyllin25% podophyllin (in benzoin tincture) is indicated for the removal of soft genital (venereal) warts (condylomata acuminata).
  • 10% hydrate skin
  • 15% accelerate fibrin degradation
  • 20-30% are antipruritic, break down keratin, decrease the thickness of the stratum corneum and are used in scaling conditions such as ichthysosis
  • 40% are proteolytic and may be used to dissolve and peel dystrophic nails

[Patient Self Care, 2010]
DB09096Benzoyl peroxideBenzoyl peroxide is indicated for the treatment of mild to moderate acne vulgaris and rosacea. Combined with other agents, it may be used in the treatment of more severe acne.
DB09353SulfurTopically it is indicated for dandruff, acne, Hayfever, common cold, scaly and red skin patches (seborrheic dermatitis). Poison ivy, and sumac infections.
DrugDrug NameTargetType
DB00936Salicylic acidSerum albumincarrier
DB00936Salicylic acidProstaglandin G/H synthase 1target
DB00936Salicylic acidProstaglandin G/H synthase 2target
DB00936Salicylic acidAldo-keto reductase family 1 member C1target
DB00936Salicylic acidSolute carrier family 22 member 6transporter
DB00936Salicylic acidSolute carrier family 22 member 10transporter
DB00936Salicylic acidSolute carrier family 22 member 8transporter
DB00936Salicylic acidSolute carrier family 22 member 11transporter
DB00936Salicylic acidSolute carrier organic anion transporter family member 2B1transporter
DB00936Salicylic acidMonocarboxylate transporter 1transporter
DB00936Salicylic acidSolute carrier family 22 member 7transporter
DB00936Salicylic acidCytochrome P450 2C9enzyme
DB00459AcitretinRetinoic acid receptor alphatarget
DB00459AcitretinRetinoic acid receptor RXR-betatarget
DB00459AcitretinRetinoic acid receptor gammatarget
DB00459AcitretinRetinoic acid receptor betatarget
DB00459AcitretinRetinoic acid receptor RXR-gammatarget
DB00459AcitretinRetinoic acid receptor RXR-alphatarget
DB00459AcitretinSerum albumincarrier
DB00459AcitretinRetinol-binding protein 1target
DB00459AcitretinCytochrome P450 26A1enzyme
DB00755TretinoinRetinoic acid receptor gammatarget
DB00755TretinoinRetinoic acid receptor RXR-betatarget
DB00755TretinoinRetinal dehydrogenase 1target
DB00755TretinoinRetinoic acid-induced protein 3target
DB00755TretinoinRetinoic acid receptor RXR-gammatarget
DB00755TretinoinNuclear receptor subfamily 0 group B member 1target
DB00755TretinoinRetinal dehydrogenase 2target
DB00755TretinoinRetinoic acid receptor responder protein 1target
DB00755TretinoinCytochrome P450 2C8enzyme
DB00755TretinoinCellular retinoic acid-binding protein 1transporter
DB00755TretinoinCellular retinoic acid-binding protein 2transporter
DB00755TretinoinCytochrome P450 2B6enzyme
DB00755TretinoinCytochrome P450 3A4enzyme
DB00755TretinoinCytochrome P450 3A5enzyme
DB00755TretinoinCytochrome P450 2A6enzyme
DB00755TretinoinCytochrome P450 3A7enzyme
DB00755TretinoinCytochrome P450 2C18enzyme
DB00755TretinoinCytochrome P450 2C9enzyme
DB00755TretinoinCytochrome P450 4A11enzyme
DB00755TretinoinCytochrome P450 1A1enzyme
DB00755TretinoinRetinoic acid receptor alphatarget
DB00755TretinoinRetinoic acid receptor betatarget
DB00755TretinoinOdorant-binding protein 2atarget
DB00755TretinoinRetinol-binding protein 4target
DB00755TretinoinSerum albumincarrier
DB00755Tretinoin[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrialtarget
DB00755TretinoinRetinoic acid receptor RXR-alphatarget
DB00755TretinoinCytochrome P450 26A1target
DB00755TretinoinCytochrome P450 26B1target
DB00755TretinoinCytochrome P450 26C1target
DB00755TretinoinHematopoietic prostaglandin D synthasetarget
DB00799TazaroteneRetinoic acid receptor alphatarget
DB00799TazaroteneRetinoic acid receptor RXR-betatarget
DB00799TazaroteneRetinoic acid receptor gammatarget
DB00799TazaroteneRetinoic acid receptor betatarget
DB00799TazaroteneCytochrome P450 2C8enzyme
DB00926EtretinateRetinoic acid receptor alphatarget
DB00926EtretinateRetinoic acid receptor RXR-betatarget
DB00926EtretinateRetinoic acid receptor gammatarget
DB00926EtretinateRetinoic acid receptor betatarget
DB00926EtretinateRetinoic acid receptor RXR-gammatarget
DB00926EtretinateRetinoic acid receptor RXR-alphatarget
DB00926EtretinateCellular retinoic acid-binding protein 1carrier
DB00926EtretinateCytochrome P450 19A1enzyme
DB00926EtretinateCytochrome P450 26A1enzyme
DB01179PodofiloxDNA topoisomerase 2-alphatarget
DB01179PodofiloxCytochrome P450 2C19enzyme
DB01179PodofiloxCytochrome P450 3A4enzyme
DB01179PodofiloxTubulin alpha-4A chaintarget
DB01179PodofiloxTubulin beta chaintarget
DB03085Glycolic acidGlucose-6-phosphate 1-dehydrogenasetarget
DB03085Glycolic acidGlycine oxidasetarget
DB03904UreaCarbonic anhydrase 2target
DB03904UreaStructural polyproteintarget
DB03904UreaCatenin beta-1target
DB03904UreaSulfoxide reductase catalytic subunit YedYtarget
DB03904UreaDihydrofolate reductasetarget
DB03904UreaUrea transporter 2transporter
DB03904UreaUrea transporter 1transporter