Keratolytic Agents

Name
Keratolytic Agents
Accession Number
DBCAT000884
Description

Agents that soften, separate, and cause desquamation of the cornified epithelium or horny layer of skin. They are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases.

Drugs
DrugDrug Description
Salicylic acidAn acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts.
PyrithioneAn antimicrobial agent used for the treatment of dandruff and seborrheic dermatitis.
Coal tarRelieving itching, irritation, redness, dryness, scaling, and flaking of the skin caused by psoriasis, seborrhea, or eczema.
AcitretinAn oral retinoid used in the treatment of severe psoriasis.
TretinoinA vitamin A derivative used to treat acne vulgaris, certain types of promyelocytic leukemia, and fine wrinkles.
TazaroteneAn acetylenic retinoid used to treat fine wrinkles, mottled pigmentation of the skin, acne vulgaris, and plaque psoriasis.
EtretinateFor the treatment of severe psoriasis in adults.
PodofiloxA topical agent used for the treatment of external genital warts and perianal warts.
Glycolic acidNot Available
PodophyllinA cytotoxic agent used for the removal of soft genital (venereal) warts (condylomata acuminata).
UreaA keratolytic emollient used to treat hyperkeratotic lesions and moisturize the skin.
Benzoyl peroxideAn antibacterial and anti-inflammatory agent used for the symptomatic treatment of mild to moderate acne vulgaris and rosacea.
OctasulfurAn ingredient of various cosmetic preparations for its keratolytic, antifungal, and antibacterial properties.
Drugs & Drug Targets
DrugTargetType
Salicylic acidSerum albumincarrier
Salicylic acidProstaglandin G/H synthase 1target
Salicylic acidProstaglandin G/H synthase 2target
Salicylic acidAldo-keto reductase family 1 member C1target
Salicylic acidSolute carrier family 22 member 6transporter
Salicylic acidSolute carrier family 22 member 10transporter
Salicylic acidSolute carrier family 22 member 8transporter
Salicylic acidSolute carrier family 22 member 11transporter
Salicylic acidSolute carrier organic anion transporter family member 2B1transporter
Salicylic acidMonocarboxylate transporter 1transporter
Salicylic acidSolute carrier family 22 member 7transporter
Salicylic acidCytochrome P450 2C9enzyme
AcitretinRetinoic acid receptor alphatarget
AcitretinRetinoic acid receptor RXR-betatarget
AcitretinRetinoic acid receptor gammatarget
AcitretinRetinoic acid receptor betatarget
AcitretinRetinoic acid receptor RXR-gammatarget
AcitretinRetinoic acid receptor RXR-alphatarget
AcitretinSerum albumincarrier
AcitretinRetinol-binding protein 1target
AcitretinRetinoic acid receptor RXRtarget
TretinoinRetinoic acid receptor gammatarget
TretinoinRetinoic acid receptor RXR-betatarget
TretinoinRetinal dehydrogenase 1target
TretinoinRetinoic acid-induced protein 3target
TretinoinRetinoic acid receptor RXR-gammatarget
TretinoinRetinal dehydrogenase 2target
TretinoinRetinoic acid receptor responder protein 1target
TretinoinCytochrome P450 2C8enzyme
TretinoinCellular retinoic acid-binding protein 1transporter
TretinoinCellular retinoic acid-binding protein 2transporter
TretinoinCytochrome P450 2B6enzyme
TretinoinCytochrome P450 3A4enzyme
TretinoinCytochrome P450 3A5enzyme
TretinoinCytochrome P450 2A6enzyme
TretinoinCytochrome P450 3A7enzyme
TretinoinCytochrome P450 2C18enzyme
TretinoinCytochrome P450 2C9enzyme
TretinoinCytochrome P450 4A11enzyme
TretinoinCytochrome P450 1A1enzyme
TretinoinRetinoic acid receptor alphatarget
TretinoinRetinoic acid receptor betatarget
TretinoinLipocalin-1target
TretinoinOdorant-binding protein 2atarget
TretinoinRetinol-binding protein 4target
TretinoinSerum albumincarrier
Tretinoin[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrialtarget
TretinoinRetinoic acid receptor RXR-alphatarget
TretinoinCytochrome P450 26A1target
TretinoinCytochrome P450 26B1target
TretinoinCytochrome P450 26C1target
TretinoinHematopoietic prostaglandin D synthasetarget
TazaroteneRetinoic acid receptor alphatarget
TazaroteneRetinoic acid receptor RXR-betatarget
TazaroteneRetinoic acid receptor gammatarget
TazaroteneRetinoic acid receptor betatarget
TazaroteneCytochrome P450 2C8enzyme
EtretinateRetinoic acid receptor alphatarget
EtretinateRetinoic acid receptor RXR-betatarget
EtretinateRetinoic acid receptor gammatarget
EtretinateRetinoic acid receptor betatarget
EtretinateRetinoic acid receptor RXR-gammatarget
EtretinateRetinoic acid receptor RXR-alphatarget
EtretinateCellular retinoic acid-binding protein 1carrier
EtretinateCytochrome P450 19A1enzyme
PodofiloxDNA topoisomerase 2-alphatarget
PodofiloxTubulin alpha-4A chaintarget
PodofiloxTubulin beta chaintarget
Glycolic acidGlucose-6-phosphate 1-dehydrogenasetarget
UreaArginase-1target
UreaCarbonic anhydrase 2target
UreaCatenin beta-1target
UreaSulfoxide reductase catalytic subunit YedYtarget
UreaUrea transporter 2transporter
UreaUrea transporter 1transporter
UreaDihydrofolate reductasetarget