- Benzoyl peroxide
- Accession Number
- Small Molecule
Benzoyl peroxide (BPO) is an organic compound in the peroxide family. It is formed by two benzoyl groups which are connected by a peroxide link. It is one of the most important organic peroxides in terms of applications. In medicine, benzoyl peroxide is used as a topical treatment for acne, either in combination with antibiotics or as a single agent. These products are available over-the-counter or by prescription in gels, creams or liquids at concentrations of 2.5%, 5% or 10%. Benzoyl peroxide is also used for bleaching flour or hair, teeth whitening, for cross-linking polyester resins, and many other chemical uses. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.
- Benzoyl benzenecarboperoxoate
- Benzoyl peroxide
- Peróxido de benzoilo
- External IDs
- NSC-671 / NSC-675
- Active Moieties
Name Kind UNII CAS InChI Key Benzoic acid unknown 8SKN0B0MIM 65-85-0 WPYMKLBDIGXBTP-UHFFFAOYSA-N
- Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End 10 Benzagel Gel - 10% Gel Topical Dermik Laboratories 1998-12-01 2005-10-05 Acetoxyl 10 Gel Gel Topical Valeo Pharma Corp. 1978-12-31 2006-07-31 Acetoxyl 20acne Gel Gel Topical Stiefel Laboratories, Inc. 1978-12-31 1998-07-09 Benoxyl Lotion Topical Glaxosmithkline Inc 1976-12-31 2011-12-22 Benoxyl Lotion Topical Glaxosmithkline Inc 1970-12-31 2012-12-10 Benoxyl 10% Wash Liquid Topical Stiefel Laboratories, Inc. 1980-12-31 1998-07-09 Benprox Liquid 52.5 mg/1g Topical River's Edge Pharmaceuticals, LLC 2006-11-01 2012-01-31 Benprox Gel 52.5 mg/1g Topical River's Edge Pharmaceuticals, LLC 2006-11-01 2009-10-31 Benprox Lotion 52.5 mg/1g Topical Kylemore Pharmaceuticals, LLC 2010-03-01 2011-03-16 Benprox Gel 27.5 mg/1g Topical River's Edge Pharmaceuticals, LLC 2006-11-01 2011-03-31
- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End 111 Medco Benzoyl Peroxide Soap 100 mg/1g Topical 111 Medco 2019-04-02 Not applicable 2.5 Benzagel 2.5% Gel Topical Rhone Poulenc Rorer 1993-12-31 1997-08-13 2.5 Benzagel 2.5% Acne Gel Gel Topical Novartis 1996-09-29 1999-07-21 2.5 Benzagel Acne Lotion 2.5% Lotion Topical Novartis 1996-09-30 1999-07-21 2.5 Benzagel Acne Lotion 2.5% Lotion Topical Rhone Poulenc Rorer 1993-12-31 1997-08-13 24 Hour Acne Serum Gel 5 g/100g Topical Neutraderm, Inc. 2019-02-08 Not applicable 5 Benzagel Liquid Acne Soap 5% Liquid Topical Rhone Poulenc Rorer 1993-12-31 1996-09-09 5 Benzagel Lotion 5% Lotion Topical Rhone Poulenc Rorer 1993-12-31 1997-08-13 5% BP Face and Body Wash Liquid 50 mg/1mL Topical CosMedical Technologies 2015-11-04 Not applicable AB Skincare Acne Spot Treatment Cream 28.3 g/100g Topical Norris Ltd 2017-10-09 Not applicable
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End 3 Step Acne System Well at Walgreens Benzoyl peroxide (2.5 g/100mL) + Benzoyl peroxide (2.5 g/100mL) Kit Topical Walgreens 2014-07-15 Not applicable 3 Step Acne System Well at Walgreens Benzoyl peroxide (2.5 g/100mL) + Benzoyl peroxide (2.5 g/100mL) Kit Topical Walgreens 2014-07-15 Not applicable Acanya Benzoyl peroxide (25 mg/1g) + Clindamycin phosphate (10 mg/1g) Gel Topical Valent Pharmaceuticals North America 2010-07-26 Not applicable Acanya Benzoyl peroxide (25 mg/1g) + Clindamycin phosphate (10 mg/1mL) Kit Topical Dow Pharmaceuticals Sciences 2009-02-03 2014-04-30 Acne Clearning Treatment Face Benzoyl peroxide (.006 mg/.024mg) + Octasulfur (.012 mg/.024mg) + Salicylic acid (.0048 mg/.024mg) Liquid Topical Care Pluss Pharma S.A. De C.V. 2012-08-06 Not applicable Acne Treatment Kit Prescription Care Benzoyl peroxide (2.5 g/100mL) + Benzoyl peroxide (2.5 g/100mL) Kit Topical Blue Cross Laboratories 2009-11-01 2016-12-05 Acne Treatment Kit Prescription Care Benzoyl peroxide (2.5 g/100mL) + Benzoyl peroxide (2.5 g/100mL) Kit Topical Blue Cross Laboratories 2009-11-01 2016-12-05 Acne Treatment System Benzoyl peroxide (50 mg/1mL) + Salicylic acid (20 mg/1mL) Kit Topical Vivier Pharma 2017-11-11 Not applicable Acne Treatment System Benzoyl peroxide (5 %) + Salicylic acid (2 %) Kit; Liquid; Lotion Topical Vivier Canada Incorporated 2013-11-15 Not applicable Acne Vanishing Gel- 10% with Sulfur Benzoyl peroxide (10 g/100mL) + Octasulfur (3 g/100mL) Gel Topical Only Yourx, Inc. 2014-03-28 Not applicable
- Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Adapalene 0.1% / Benzoyl Peroxide 2.5% / Clindamycin 1% Benzoyl peroxide (2.5 g/100g) + Adapalene (0.1 g/100g) + Clindamycin phosphate (1 g/100g) Gel Topical Sincerus Florida, LLC 2019-05-10 Not applicable Adapalene 0.1% / Benzoyl Peroxide 2.5% / Niacinamide 4% Benzoyl peroxide (2.5 g/100g) + Adapalene (0.1 g/100g) + Nicotinamide (4 g/100g) Gel Topical Sincerus Florida, LLC 2019-05-10 Not applicable Adapalene 0.3% / Benzoyl Peroxide 2.5% / Clindamycin 1% Benzoyl peroxide (2.5 g/100g) + Adapalene (0.3 g/100g) + Clindamycin phosphate (1 g/100g) Gel Topical Sincerus Florida, LLC 2019-05-01 Not applicable Adapalene 0.3% / Benzoyl Peroxide 2.5% / Niacinamide 4% Benzoyl peroxide (2.5 g/100g) + Adapalene (0.3 g/100g) + Nicotinamide (4 g/100g) Gel Topical Sincerus Florida, LLC 2019-05-01 Not applicable Bencort Benzoyl peroxide (350 mg/1g) + Benzoyl peroxide (50 mg/1g) + Hydrocortisone (5 mg/1g) Kit Topical River's Edge Pharmaceuticals, LLC 2009-10-01 2011-01-13 Bencort Benzoyl peroxide (350 mg/1g) + Benzoyl peroxide (50 mg/1g) + Hydrocortisone (5 mg/1g) Kit Topical River's Edge Pharmaceuticals, LLC 2009-10-01 2011-01-13 BenoxylDoxy 30 Kit Benzoyl peroxide (44 mg/1mL) + Doxycycline monohydrate (100 mg/1) Kit Topical Elorac, Inc. 2014-07-01 2014-08-07 BenoxylDoxy 60 Kit Benzoyl peroxide (44 mg/1mL) + Doxycycline monohydrate (100 mg/1) Kit Topical Elorac, Inc. 2014-07-01 2015-07-18 Benprox Benzoyl peroxide (52.5 mg/1g) Lotion Topical Kylemore Pharmaceuticals, LLC 2010-03-01 2011-03-16 Benprox Benzoyl peroxide (52.5 mg/1g) Liquid Topical River's Edge Pharmaceuticals, LLC 2006-11-01 2012-01-31
- CAS number
- Average: 242.2268
- Chemical Formula
- InChI Key
- IUPAC Name
- benzoyl benzenecarboperoxoate
Benzoyl peroxide is indicated for the treatment of mild to moderate acne vulgaris and rosacea. Combined with other agents, it may be used in the treatment of more severe acne.
- Associated Conditions
Benzoyl peroxide acts as an antibacterial, irritant, keratolytic, comedolytic, and anti-inflammatory agent when applied topically to the human epithelium.
- Mechanism of action
Benzoyl peroxide decomposes to release oxygen after topical application. This oxygen acts as a bactericidal agent towards Proprionibacterium acnes, the bacteria present in acne vulgaris. Benzoyl peroxide also increases the turnover rate of epithelial cells, thereby peeling the skin and promoting the resolution of comedones.
Benzoyl peroxide is absorbed percutaneously into the dermal layer of the epithelium. It is then metabolized to benzoic acid which can be absorbed systemically. There is no systemic absorption of benzoyl peroxide itself.
- Volume of distribution
Benzoyl peroxide is not absorbed or distributed systemically after topical application.
- Protein binding
Benzoyl peroxide does not undergo protein binding as it is does not enter systemic circulation after topical application.
Benzoyl peroxide undergoes metabolism by keratinocytes in the epidermis. Initially, the peroxide bond is cleaved to form benzoyloxyl radicals. It is thought this reaction may be copper-catalyzed. The benzoyloxyl radicals may then fragment to form carbon dioxide and a phenyl radical. Alternatively, the radicals may gain a hydrogen atom from biomolecules forming the more stable and primary metabolite, benzoic acid.
- Route of elimination
Renal clearance of the primary metabolite, benzoic acid, is rapid and thought to preclude hepatic conjugation.
- Half life
Benzoyl peroxide is not absorbed into systemic circulation after topical application. Further studies are needed on its half life within the epithelium.
Benzoyl peroxide is not absorbed into systemic circulation after topical application. Its primary metabolite, benzoic acid, is cleared rapidly via renal excretion and hepatic conjugation is thought to be bypassed.
There is no evidence to support carcinogenicity in humans. Benzoyl peroxide may cause contact hypersensitivity, stinging and burning sensations when applied topically. It should not be applied under occlusive dressings due to risk of sensitization. During processing and formulation, exposure to concentrations higher than 12.2 mg/cu may cause irritation to the nose and/or throat.
- Affected organisms
- Propionibacterium acnes
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.Learn more
Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.Learn more
Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.Learn more
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Dapsone The risk or severity of adverse effects can be increased when Benzoyl peroxide is combined with Dapsone.Additional Data Available
- Extended DescriptionExtended Description
Extended description of the mechanism of action and particular properties of each drug interaction.Learn more
A severity rating for each drug interaction, from minor to major.Learn more
- Evidence LevelEvidence Level
A rating for the strength of the evidence supporting each drug interaction.Learn more
An effect category for each drug interaction. Know how this interaction affects the subject drug.Learn more
- Food Interactions
- Not Available
- Synthesis Reference
- Zenz, C. Occupational Medicine - Principles and Practical Applications. 2nd ed. St. Louis, MO: Mosby-Yearbook Inc.; 1988: 712.
- Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc.; 1996: 187.
- Ashford, RD. Ashford's Dictionary of Industrial Chemicals. London, England: Wavelength Publications Ltd.; 1994: 119.
- General References
- Bojar RA, Cunliffe WJ, Holland KT: The short-term treatment of acne vulgaris with benzoyl peroxide: effects on the surface and follicular cutaneous microflora. Br J Dermatol. 1995 Feb;132(2):204-8. [PubMed:7888356]
- Kawashima M, Nagare T, Katsuramaki T: Open-label, randomized, multicenter, phase III study to evaluate the safety and efficacy of benzoyl peroxide gel in long-term use in patients with acne vulgaris: A secondary publication. J Dermatol. 2017 Feb 2. doi: 10.1111/1346-8138.13741. [PubMed:28150367]
- Francis NA, Entwistle K, Santer M, Layton AM, Eady EA, Butler CC: The management of acne vulgaris in primary care: a cohort study of consulting and prescribing patterns using the Clinical Practice Research Datalink. Br J Dermatol. 2017 Jan;176(1):107-115. doi: 10.1111/bjd.15081. Epub 2016 Dec 27. [PubMed:27716910]
- Rosamilia LL: Over-the-counter treatments for acne and rosacea. Semin Cutan Med Surg. 2016 Jun;35(2):87-95. doi: 10.12788/j.sder.2016.026. [PubMed:27416314]
- Yeung D, Nacht S, Bucks D, Maibach HI: Benzoyl peroxide: percutaneous penetration and metabolic disposition. II. Effect of concentration. J Am Acad Dermatol. 1983 Dec;9(6):920-4. [PubMed:6643790]
- Nacht S, Yeung D, Beasley JN Jr, Anjo MD, Maibach HI: Benzoyl peroxide: percutaneous penetration and metabolic disposition. J Am Acad Dermatol. 1981 Jan;4(1):31-7. [PubMed:7204686]
- Swauger JE, Dolan PM, Zweier JL, Kuppusamy P, Kensler TW: Role of the benzoyloxyl radical in DNA damage mediated by benzoyl peroxide. Chem Res Toxicol. 1991 Mar-Apr;4(2):223-8. [PubMed:1782351]
- External Links
- ATC Codes
- D10AE01 — Benzoyl peroxide
- D10AE — Peroxides
- D10A — ANTI-ACNE PREPARATIONS FOR TOPICAL USE
- D10 — ANTI-ACNE PREPARATIONS
- D — DERMATOLOGICALS
- AHFS Codes
- 84:28.00 — Keratolytic Agents
- Download (37.4 KB)
- Clinical Trials
Phase Status Purpose Conditions Count 0 Recruiting Treatment Osteomyelitis 1 1 Completed Prevention Acne Vulgaris 1 1 Completed Treatment Acne Vulgaris 7 1, 2 Recruiting Treatment Acne Vulgaris Superficial Mixed Comedonal and Inflammatory 1 2 Completed Prevention Surgical Site Infections 1 2 Completed Treatment Acne 1 2 Completed Treatment Acne Vulgaris 2 2 Completed Treatment Actinic Keratosis (AK) 1 3 Completed Treatment Acne 6 3 Completed Treatment Acne Vulgaris 18 3 Not Yet Recruiting Prevention Cutibacterium Acnes Infection 1 3 Recruiting Prevention Infection / Post Operative Infection Arthroscopic Shoulder Surgery 1 3 Unknown Status Treatment Acne Vulgaris 2 3 Withdrawn Treatment Acne Vulgaris 1 4 Active Not Recruiting Prevention Propionibacterium Acnes 1 4 Completed Not Available Acne Vulgaris 1 4 Completed Not Available P Acnes Colonization 1 4 Completed Prevention Acne Vulgaris / Atrophic Acne Scars 1 4 Completed Supportive Care Acne 1 4 Completed Treatment Acne 5 4 Completed Treatment Acne Vulgaris 26 4 Completed Treatment Acne Vulgaris / Post Inflammatory Hyperpigmentation 1 4 Completed Treatment Skin Diseases 1 4 Not Yet Recruiting Treatment Acne 1 4 Recruiting Treatment Acne Vulgaris 1 4 Recruiting Treatment Benzoyl Peroxide / Foot Dermatoses 1 4 Unknown Status Treatment Acne Vulgaris 2 4 Unknown Status Treatment Treatment of Acne Vulgaris Grade II in a Short Period of Time 1 4 Withdrawn Prevention Coronary Arterioscleroses / Platelet Dysfunction Due to Drugs 1 Not Available Completed Not Available Acne 1 Not Available Completed Not Available Acne Vulgaris 2 Not Available Completed Prevention Shoulder Infection 1 Not Available Completed Treatment Acne Vulgaris 10 Not Available Completed Treatment Facial Acne / Local Adverse Effects 1 Not Available Not Yet Recruiting Treatment Acne 1 Not Available Unknown Status Treatment Hidradenitis Suppurativa (HS) 1
- Not Available
- Not Available
- Dosage forms
Form Route Strength Cream Topical 28.3 g/100g Cream Topical 104 mg/10g Lotion Topical 0.025 g/100mL Lotion Topical 2.5 mg/1mL Liquid Topical Gel Topical 5 mL/100mL Shampoo, suspension Topical 25 mg/1mL Lotion Topical 100 mg/1000mL Lotion Topical 50 mg/1000mL Aerosol, foam Topical 2.5 mg/1g Lotion Topical 2.5 mL/100mL Lotion Topical 5 % Cream Topical 10 g/100mL Lotion Topical 30 mg/1g Cream Topical 0.026 mg/1mg Gel Topical 1 mg/1g Gel Topical 3.5 g/100mL Kit; liquid; lotion Topical Cream Topical 25 mg/1mL Kit Topical 25 mg/1mL Liquid Topical 4.25 g/170g Cream Topical 3.4 g/136g Liquid Topical 25 mg/1mL Lotion Topical 10 mL/100mL Kit; lotion Topical Gel; kit; lotion Topical Aerosol, foam Topical 2.5 g/100g Aerosol, foam Topical 5 g/100g Cream Topical 5.5 g/100mL Lotion Transdermal 5.5 g/100mL Cream Topical 1.4 g/28g Gel Topical 25 mg/1mL Liquid, extended release Topical 44 mg/1mL Gel Topical 27.5 mg/1g Liquid Topical 52.5 mg/1g Solution Topical 2.6 g/100mL Gel Topical Solution Topical Liquid Topical Cream Topical 100 mg/1g Cream Topical 50 mg/1g Aerosol, foam Topical 3.18 g/60g Cloth Topical 60 mg/1 Soap Topical 7 g/100g Lotion Topical 3 g/100mL Aerosol, foam Topical 53 mg/1g Emulsion Topical 45 mg/1mL Emulsion Topical 65 mg/1mL Emulsion Topical 85 mg/1mL Gel Topical 10 g/100g Gel Topical 100 mg/1g Gel Topical 50 mg/1g Liquid Topical 10 g/100g Liquid Topical 100 mg/1mL Liquid Topical 2.5 g/100g Liquid Topical 30 mg/1mL Liquid Topical 50 mg/1mL Liquid Topical 57.5 mg/1mL Liquid Topical 60 mg/1mL Liquid Topical 70 g/1mL Liquid Topical 70 mg/1g Liquid Topical 90 mg/1mL Solution Topical 3 g/100mL Solution Topical 4 g/100g Solution Topical 45 mg/1mL Solution Topical 6 g/100mL Solution Topical 65 mg/1mL Solution Topical 8 g/100g Solution Topical 85 mg/1mL Solution Topical 9 g/100mL Gel Topical 50 mg/1000mg Suspension Topical Gel Topical 2.5 g/100g Gel Topical 35 mg/1g Cream Topical 4 g/100g Cream Topical 8 g/100g Aerosol, foam Topical 5.3 g/100g Aerosol, foam Topical 98 mg/1g Aerosol, foam Topical 9.8 g/100g Emulsion Topical 57.5 mg/1mL Emulsion Topical 70 mg/1mL Cream Topical 3.29 g/56g Gel Topical 100 mg/1mL Gel Topical 50 mg/1mL Emulsion Topical 42.5 mg/1mL Gel Topical 55 mg/1g Emulsion Topical 100 mg/1g Emulsion Topical 50 mg/1g Emulsion Topical 52.5 mg/1g Lotion Topical 52.5 mg/1g Gel Topical 4 mg/100mg Gel Topical 8 mg/100mg Cloth Topical 3.2 g/100g Cloth Topical 9 g/100g Lotion Topical 5 mL/100mL Cream Topical 13.6 g/170.1g Cream Topical 6.8 g/170.1g Gel Topical 40 mg/1g Gel Topical 80 mg/1g Cream Topical 1.125 g/15g Aerosol Topical Lotion Topical Liquid Topical 5.57 mg/1g Liquid Topical .006 mg/.024mg Lotion Topical Cream Topical 30 mg/1mL Cream Topical 7.5 mg/100mL Cream Topical Cloth Topical Kit; lotion Topical Lotion Topical 50 mg/1mL Gel Topical 70 mg/1g Cream Topical 0.8 mg/29.6mg Gel Topical 61.62 mg/1mL Gel Topical 60 mg/1mL Soap Topical 100 mg/1g Liquid Topical 35 mg/1g Lotion Topical 35 mg/1g Solution Topical 10 mg/1mL Solution Topical 10 mg/1g Solution Topical 5 mg/1mL Solution Topical 5 mg/1g Solution Topical 5 g/100mL Lotion Topical 2.5 g/100mL Gel; lotion Topical Cream Topical 58.7 mg/1g Cloth Topical Aerosol, foam Topical 9.8 g/1g Liquid, extended release Topical 4.5 mg/100mL Liquid Topical 0.1 mg/1g Gel Topical 135 mg/1g Liquid Topical 3 g/120g Lotion Topical 1.5 g/60g Lotion Topical 25 mg/1mL Ointment Topical Gel Topical Liquid Topical 5 g/100g Gel Topical 5.6 g/56g Gel Topical 3 mL/60mL Gel Topical 2.8 g/56.7g Lotion Topical 45 mg/1mL Gel Topical 51.9 mg/100mL Cream Topical 10 g/100g Cream Topical 60 mg/1g Lotion Topical 70 mg/1mL Liquid Topical 70 mg/1mL Lotion / shampoo Topical 25 mg/1mL Lotion Topical 0.0625 kg/1kg Cream Topical 5.3 g/100g Gel Topical 10 g/100mL Suspension Topical 10 g/100g Soap Topical 10 g/100g Lotion Topical 55 mg/1mL Lotion Topical 2.2 mg/40mL Kit Topical 7 mg/1g Gel Topical 52.5 mg/1g Aerosol, foam Topical 25 mg/1g Aerosol, foam Topical 80 mg/1g Cream Topical 1 g/100g Cream Topical 5 g/100mL Cream Topical 35 mg/1g Cream Topical 55 mg/1g Cream Topical 85 mg/1g Solution Topical 70 mg/1g Kit Topical Lotion Topical 70 mg/1g Paste Topical Gel Topical 3.5 % Gel Topical 35 mg/1mL Lotion Topical 35 mg/1mL Cream Topical 37 mg/1mL Suspension Topical 37 mg/1mL Jelly Topical Cream Topical 2.5 mg/1g Gel Topical 25 mg/1g Cream Topical 35 mg/1mL Lotion Topical 0.05 mL/1mL Lotion Topical 5 g/100mL Gel Topical 7 mg/1g Solution Topical 2.5 g/100mL Cream Topical 2.5 g/100g Lotion Topical 2.5 % Gel Topical 0.102 g/1g Lotion Topical 100 mg/1g Lotion Topical 50 mg/1g Cream Topical 100 mg/1mL Cream Topical 50 mg/1mL Swab Topical 25 mg/1 Stick Topical 50 mg/1g Cloth Topical 70 mg/1g Cloth Topical 42.5 mg/1g Solution Topical 42.5 mg/1g Cream Topical 146.7 mg/1g Cream Topical 30 mg/1g Soap Topical 0.5 g/10g Soap Topical 1 g/10g Soap Topical 11.3 g/1 Soap Topical 5.65 g/1 Cream Topical 117.3 mg/1g Soap Topical Kit; lotion; solution Topical Cream Topical 5 g/100g Gel Topical 5 g/100g Solution Topical 0.063 mg/2.5mL Lotion Topical 0.063 mg/2.5mL Cream Topical 25 mg/1g Gel Topical 5 g/100mL Gel; kit Topical Cream Topical 0.05 g/1g Cream Topical 0.06 g/1g Cream Topical 5 % Lotion Topical 7 mg/100mL Cream Topical 7 mg/100mL Gel Topical 8.5 mg/100mL Lotion Topical 7 g/100mL Cream Topical 0.025 g/1000mL Cream Topical 0.25 g/1000mL Lotion Topical 2.5 mg/100mL Gel Topical 2.5 mg/100mL Gel Topical 2.5 g/100mL Soap Topical 2.5 g/100mL Cream Topical 52.5 mg/1mL Emulsion Topical 25 mg/1g Liquid Topical 7.5 mL/100mL Cream Topical 2.95 mL/59mL Aerosol, foam Topical 55 mg/1g Aerosol, foam Topical 95 mg/1g Cream Topical 2.5 mL/100mL Cream; kit; lotion Topical Cream; gel; kit; lotion Topical Lotion Topical 100 mg/1mL Kit Topical 0.5 mg/1g Swab Topical 25 mg/1mL Lotion Topical 25 mg/1g Lotion Topical 2.5 g/100g Lotion Topical 5 g/100g Lotion Topical 10 g/100mL Ointment Topical 9.48 mg/100mg Lotion Topical 0.025 g/1mL Cream Topical 0.05 g/1mL Gel; kit; paste Topical Cream Topical Lotion Topical 2.50 g/100g Soap Topical 5 g/100mL Soap Topical 60 mg/1g Cloth Topical 30 mg/1g Cloth Topical 60 mg/1g Cloth Topical 90 mg/1g Gel Topical 5 g/99.8g Cream Topical 3.7 mL/100mL Swab Topical 2.75 mg/1 Gel Topical 8.5 mg/100g Gel Topical 8.5 g/100g Lotion Topical 40 mg/1g Lotion Topical 80 mg/1g Ointment Topical 100 mg/1g Gel Topical 45 mg/1mL
- Not Available
Patent Number Pediatric Extension Approved Expires (estimated) US8909305 No 2014-12-09 2022-12-23 US8703820 No 2014-04-22 2023-03-12 US7964202 No 2011-06-21 2024-09-01 US8071644 No 2011-12-06 2027-07-18 US8080537 No 2011-12-20 2027-07-18 US8105618 No 2012-01-31 2022-12-23 US8129362 No 2012-03-06 2027-07-18 US8445543 No 2013-05-21 2027-07-12 US8809305 No 2014-08-19 2022-12-23 US8936800 No 2015-01-20 2022-12-23 US8241649 No 2012-08-14 2022-12-23 US7820186 No 2010-10-26 2025-11-23 US8288434 No 2012-10-16 2029-08-05 US8663699 No 2014-03-04 2029-06-03 US8895070 No 2014-11-25 2029-06-03 US9078870 No 2015-07-14 2029-06-03 US8785420 No 2014-07-22 2022-12-23 US8729127 No 2014-05-20 2023-03-12 US9504704 No 2016-11-29 2029-06-03 US9561208 No 2017-02-07 2029-06-03 US9381179 No 2016-07-05 2023-03-12 US9387187 No 2016-07-12 2023-03-12 US9814690 No 2017-11-14 2022-12-23 US10137142 No 2018-11-27 2029-06-03 US10220049 No 2019-03-05 2029-06-03Additional Data Available
- Filed OnFiled On
The date on which a patent was filed with the relevant government.Learn more
- Experimental Properties
Property Value Source melting point (°C) 103 - 106 Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc.; 1996: 187. boiling point (°C) Decomposes explosively above melting point. Does not reach boiling point. United States Department of Labor. OSHA Occupational Chemical Database. Occupational Safety and Health Administration website. https://www.osha.gov/chemicaldata/chemResult.html?RecNo=748. Accessed February 22, 2017. water solubility <1% United States Department of Labor. OSHA Occupational Chemical Database. Occupational Safety and Health Administration website. https://www.osha.gov/chemicaldata/chemResult.html?RecNo=748. Accessed February 22, 2017.
- Predicted Properties
Property Value Source Water Solubility 0.0294 mg/mL ALOGPS logP 2.75 ALOGPS logP 3.95 ChemAxon logS -3.9 ALOGPS pKa (Strongest Basic) -7.2 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 2 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 52.6 Å2 ChemAxon Rotatable Bond Count 5 ChemAxon Refractivity 64.77 m3·mol-1 ChemAxon Polarizability 24.16 Å3 ChemAxon Number of Rings 2 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon
- Predicted ADMET features
- Not Available
- Mass Spec (NIST)
- Not Available
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
- This compound belongs to the class of organic compounds known as benzoyl peroxides. These are organic compounds containing two benzoyl groups O-linked to each other via a peroxide group. Their skeleton has the general formula [C6H5C(O)]2O2.
- Organic compounds
- Super Class
- Benzene and substituted derivatives
- Sub Class
- Benzoyl peroxides
- Direct Parent
- Benzoyl peroxides
- Alternative Parents
- Peroxybenzoic acids and derivatives / Benzoyl derivatives / Dicarboxylic acids and derivatives / Peroxycarboxylic acids and derivatives / Carboxylic acid salts / Organooxygen compounds / Organic salts / Organic oxides / Hydrocarbon derivatives
- Benzoyl peroxide / Peroxybenzoate / Benzoic acid or derivatives / Benzoyl / Dicarboxylic acid or derivatives / Peroxycarboxylic acid or derivatives / Carboxylic acid salt / Carboxylic acid derivative / Organic oxygen compound / Organic oxide
- Molecular Framework
- Aromatic homomonocyclic compounds
- External Descriptors
- carbonyl compound (CHEBI:82405)
Drug created on September 16, 2015 12:04 / Updated on December 12, 2019 07:27