Identification
NameBenzoyl peroxide
Accession NumberDB09096
TypeSmall Molecule
GroupsApproved
Description

Benzoyl peroxide (BPO) is an organic compound in the peroxide family. It consists of two benzoyl groups bridged by a peroxide link. It is one of the most important organic peroxides in terms of applications. In medicine, benzoyl peroxide is used as a topical treatment for acne, either in combination with antibiotics or as a single agent. These products are available over-the-counter or by prescription in gels, creams or liquids at concentrations of 2.5%, 5% or 10%. Benzoyl peroxide is also used for bleaching flour or hair, teeth whitening, for cross-linking polyester resins, and many other chemical uses. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.

Structure
Thumb
Synonyms
Benzoyl benzenecarboperoxoate
Bepio
External IDs Not Available
Product Ingredients Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
10 Benzagel Gel - 10%Gel10 %TopicalDermik Laboratories1998-12-012005-10-05Canada
Acetoxyl 10 GelGel10 %TopicalValeo Pharma Corp.1978-12-312006-07-31Canada
Acetoxyl 20acne GelGel20 %TopicalStiefel Laboratories, Inc.1978-12-311998-07-09Canada
BenoxylLotion10 %TopicalGlaxosmithkline Inc1976-12-312011-12-22Canada
BenoxylLotion20 %TopicalGlaxosmithkline Inc1970-12-312012-12-10Canada
Benoxyl 10% WashLiquid10 %TopicalStiefel Laboratories, Inc.1980-12-311998-07-09Canada
Benzac Ac Gel 10%Gel10 %TopicalGalderma1991-12-312016-08-04Canada
Benzac W Wash Gel 10%Gel10 %TopicalGalderma1991-12-31Not applicableCanada
Benzac W10 Gel 10% USPGel10 %TopicalGalderma1980-12-312005-08-04Canada
Benzagel 10 Gel 10%Gel10 %TopicalRhone Poulenc Rorer1993-12-311999-08-12Canada
Dermoxyl Aqua Gel 10%Gel10 %TopicalIcn Pharmaceuticals1992-12-312005-04-26Canada
Dermoxyl Aqua Gel 20%Gel20 %TopicalIcn Pharmaceuticals1992-12-312005-04-26Canada
Dermoxyl Gel 10%Gel10 %TopicalIcn Pharmaceuticals1977-12-312005-04-26Canada
Dermoxyl Gel 20%Gel20 %TopicalIcn Pharmaceuticals1977-12-312005-04-26Canada
Desquam-X Gel 10%Gel10 %TopicalWestwood Squibb, Division Of Bristol Myers Squibb Canada Inc.1991-12-312009-04-17Canada
Desquam-X Wash Lot 10%Lotion10 %TopicalWestwood Squibb, Division Of Bristol Myers Squibb Canada Inc.1982-12-312006-07-31Canada
H2 Oxyl 10%Cream10 %TopicalStiefel Laboratories, Inc.1981-12-311998-07-09Canada
H2 Oxyl 20%Cream20 %TopicalStiefel Laboratories, Inc.1981-12-311998-07-09Canada
Oxyderm Lot 20%Lotion20 %TopicalValeant Canada Lp Valeant Canada S.E.C.1979-12-312014-07-30Canada
Oxyderm Lotion 10%Lotion10 %TopicalValeant Canada Lp Valeant Canada S.E.C.1979-12-312014-07-30Canada
Panoxyl 10 Bar 10%Soap10 %TopicalGlaxosmithkline Inc1981-12-312015-08-04Canada
Panoxyl 10 GelGel10 %TopicalGlaxosmithkline Inc1973-12-312014-10-01Canada
Panoxyl 20 GelGel20 %TopicalGlaxosmithkline Inc1976-12-312014-04-01Canada
Panoxyl Aquagel 10 - Gel 10%Gel10 %TopicalStiefel Laboratories, Inc.1997-01-202003-08-04Canada
Panoxyl Aquagel 20 - Gel Top 20%Gel20 %TopicalStiefel Laboratories, Inc.1997-01-202003-10-20Canada
Panoxyl Wash 10 - Liq Top 10%Liquid10 %TopicalStiefel Laboratories, Inc.1997-01-201999-02-03Canada
PersaclearCream10 %TopicalJohnson & JohnsonNot applicableNot applicableCanada
SolugelGel8 %TopicalGlaxosmithkline Inc1993-12-312014-04-01Canada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
2.5 Benzagel 2.5%Gel2.5 %TopicalRhone Poulenc Rorer1993-12-311997-08-13Canada
2.5 Benzagel 2.5% Acne GelGel2.5 %TopicalNovartis1996-09-291999-07-21Canada
2.5 Benzagel Acne Lotion 2.5%Lotion2.5 %TopicalRhone Poulenc Rorer1993-12-311997-08-13Canada
2.5 Benzagel Acne Lotion 2.5%Lotion2.5 %TopicalNovartis1996-09-301999-07-21Canada
3 Step Acne System Well At WalgreensKitWalgreens2014-07-15Not applicableUs
5 Benzagel Liquid Acne Soap 5%Liquid5 %TopicalRhone Poulenc Rorer1993-12-311996-09-09Canada
5 Benzagel Lotion 5%Lotion5 %TopicalRhone Poulenc Rorer1993-12-311997-08-13Canada
5% Bp Face and Body WashLiquid50 mg/mLTopicalCos Medical Technologies2015-11-04Not applicableUs
Acetoxyl 2.5 GelGel2.5 %TopicalValeo Pharma Corp.1978-12-312011-08-02Canada
Acetoxyl 5 GelGel5 %TopicalValeo Pharma Corp.1978-12-312006-07-31Canada
Acne CleanserCream104 mg/10gTopicalDolgencorp2014-02-18Not applicableUs
Acne CleanserCream104 mg/10gTopicalMeijer Distribution2014-02-18Not applicableUs
Acne CleanserCream104 mg/10gTopicalWalmart Stores2014-02-18Not applicableUs
Acne Cleansing BarSoap100 mg/gTopicalWalgreens2016-12-01Not applicableUs
Acne Clearing TreatmentLotion2.5 %TopicalRodan & FieldsNot applicableNot applicableCanada
Acne Control CleanserCream10 g/100gTopicalDolgencorp2011-10-25Not applicableUs
Acne Control SerumGel5 mL/100mLTopicalNeutraderm, Inc.2010-07-01Not applicableUs
Acne CreamCream5 %TopicalPhysicians Care Alliance Llc2013-06-01Not applicableCanada
Acne Eraser CleanserLotion5 %TopicalJohnson & JohnsonNot applicableNot applicableCanada
Acne Face and BodyShampoo, suspension25 mg/mLTopicalFace Reality Skin Care, Llc2011-09-15Not applicableUs
Acne Face and Body WashShampoo, suspension25 mg/mLTopicalFace Reality Skin Care, Llc2016-12-31Not applicableUs
Acne Fm Wsh Mx CvsCream10 g/100gTopicalCvs Health2012-06-15Not applicableUs
Acne LotionLotion2.5 %TopicalDr. Lin SkincareNot applicableNot applicableCanada
Acne MedGel25 mg/mLTopicalFace Reality Skin Care, Llc2016-12-30Not applicableUs
Acne MedGel25 mg/mLTopicalFace Reality Skin Care, Llc2016-12-30Not applicableUs
Acne MedGel25 mg/mLTopicalFace Reality Skin Care, Llc2016-12-30Not applicableUs
Acne Medication 10Gel100 mg/gTopicalA S Medication Solutions2012-10-29Not applicableUs
Acne Medication 10Lotion100 mg/1000mLTopicalRugby2012-10-29Not applicableUs
Acne Medication 10Gel100 mg/gTopicalA S Medication Solutions2012-10-29Not applicableUs
Acne Medication 10Gel100 mg/gTopicalRugby2012-10-29Not applicableUs
Acne Medication 5Gel50 mg/gTopicalA S Medication Solutions2012-10-29Not applicableUs
Acne Medication 5Gel50 mg/gTopicalA S Medication Solutions2012-10-29Not applicableUs
Acne Medication 5Gel50 mg/gTopicalRugby2012-10-29Not applicableUs
Acne Medication 5Lotion50 mg/1000mLTopicalRugby2012-10-29Not applicableUs
Acne Solutions Clearing Moisturizer Acne MedicationLotion2.5 mL/100mLTopicalClinique Laboratories, Inc.2006-09-01Not applicableUs
Acne Solutions EmergencyLotion2.5 mL/100mLTopicalClinique Laboratories, Inc.2000-12-01Not applicableUs
Acne Spot CorrectorCream5 g/100mLTopicalDr. Lin Skincare2013-06-13Not applicableUs
Acne Spot CorrectorLotion5 %TopicalDr. Lin SkincareNot applicableNot applicableCanada
Acne Spot Corrector Maximum StrengthCream10 g/100mLTopicalDr. Lin Skincare2013-06-13Not applicableUs
Acne Spot RepairLotion100 mg/gTopicalMen Science Androceuticals, Llc2017-04-20Not applicableUs
Acne Spot TreatmentCream10 g/100gTopicalCvs Health2014-10-31Not applicableUs
Acne TherapyLotion30 mg/gTopicalMen Science Androceuticals, Llc2017-04-20Not applicableUs
Acne Therapy Cleansing WashSolution5.0 %TopicalValeant Canada Lp Valeant Canada S.E.C.2010-06-182016-07-08Canada
Acne TreatmentGel1 mg/gTopicalRite Aid2011-12-02Not applicableUs
Acne TreatmentGel1 mg/gTopicalWalmart Stores2015-01-06Not applicableUs
Acne TreatmentGel1 mg/gTopicalBig Lots2016-02-23Not applicableUs
Acne TreatmentCream10 g/100gTopicalCvs Health2014-10-31Not applicableUs
Acne TreatmentGel1 mg/gTopicalMeijer2013-07-15Not applicableUs
Acne TreatmentCream.026 mg/mgTopicalI. Shay Cosmetics2015-07-13Not applicableUs
Acne Treatment GelGel5 %TopicalWaltman Pharmaceuticals IncNot applicableNot applicableCanada
Acne Treatment Kit Prescription CareKitBlue Cross Laboratories2009-11-01Not applicableUs
Acne Treatment LotionLotion3.5 %TopicalTransdermal Corp.Not applicableNot applicableCanada
Acne Treatment LotionLotion5 %TopicalVivier Canada Incorporated2011-06-07Not applicableCanada
Acne Treatment SerumGel3.5 g/100mLTopicalHalogent, LLC (DBA Exposed Skin Care)2013-02-07Not applicableUs
Acne Tx MaskCream25 mg/mLTopicalAllure Labs, Inc.2010-01-01Not applicableUs
AcnebanGel5 %TopicalNutrimmune Technologies Incorporated2010-02-172015-08-06Canada
Acnefree Clear Skin Treatments 24 Hour Acne Clearing SystemKitValeant Pharmaceuticals North America2014-06-25Not applicableUs
Acnefree Clear Skin Treatments 24 Hour Severe Acne Clearing SystemKitValeant Pharmaceuticals North America2014-06-25Not applicableUs
Acnefree Clear Skin Treatments Advanced Deep Cleansing DuoKitValeant Pharmaceuticals North America2014-06-25Not applicableUs
Acnefree Clear Skin Treatments Sonic Advanced Cleansing DuoKitValeant Pharmaceuticals North America2015-09-01Not applicableUs
Acnefree Clear Skin Treatments Terminator 2.5Cream25 mg/gTopicalValeant Pharmaceuticals North America2014-09-122017-02-22Us
Acnefree Energizing Acne CleanserLiquid4.25 g/170gTopicalValeant Pharmaceuticals North America2014-01-152016-07-31Us
Acnefree Energizing Acne Wash and ScrubCream3.4 g/136gTopicalValeant Pharmaceuticals North America2014-01-142017-02-22Us
Acnefree Oil-free Acne CleanserLiquid25 mg/mLTopicalValeant Pharmaceuticals North America2013-01-01Not applicableUs
Acnefree Original Strength TerminatorCream50 mg/gTopicalValeant Pharmaceuticals North America2014-09-152017-02-23Us
Acnefree Sensitive 24 Hour Acne Clearing SystemKitValeant Pharmaceuticals North America2014-09-11Not applicableUs
Acnefree Severe Antibacterial Cleansing WashCream2.5 mL/100mLTopicalUniversity Medical Pharmaceuticals Corp2011-12-21Not applicableUs
Acnefree Severe Maximum Strength Repair LotionLotion10 mL/100mLTopicalUniversity Medical Pharmaceuticals Corp2011-12-20Not applicableUs
Acnefree Severe Terminator Maximum StrengthCream100 mg/gTopicalValeant Pharmaceuticals North America2014-09-15Not applicableUs
Acnomel Bp 5 Lot 5%Lotion5 %TopicalChattem, Inc.1992-12-311997-12-19Canada
Adasept B.P.2.5 Acne GelGel2.5 %TopicalOdan Laboratories LtdNot applicableNot applicableCanada
Adasept B.P.5 Acne GelGel5 %TopicalOdan Laboratories Ltd2007-09-25Not applicableCanada
Adv 3n1 Exfol CvsCream5 g/100gTopicalCvs Health2013-12-16Not applicableUs
Advanced Acne WashLiquid, extended release44 mg/mLTopicalElorac, Inc.2015-08-17Not applicableUs
AF Foam Clear Skin Acne Pore CleanserAerosol, foam2.5 g/100gTopicalUniversity Medical Pharmaceuticals Corp2011-11-01Not applicableUs
Age Intervention DualityCream10 g/100gTopicalG.S. Cosmeceutical Usa, Inc.2011-05-01Not applicableUs
Age Intervention Duality MdCream10 g/100gTopicalG.S. Cosmeceutical Usa, Inc.2011-05-01Not applicableUs
Aknetrol Acne TreatmentLotion100 mg/mLTopicalZo Skin Health Inc2012-01-01Not applicableUs
All-IN-oneCream5.5 g/100mLTopicalAugustus Biomed Llc2012-02-25Not applicableUs
Aloe Clear - Acne TreatmentCream.026 mg/mgTopicalI. Shay Cosmetics2015-07-132016-10-13Us
Ambi Acne Spot TreatmentCream1.4 g/28gTopicalValeant Pharmaceuticals North America2014-01-172017-02-23Us
Anti Bac Acne ClearingLotion5 g/100mLTopicalKate Somerville Skincare Llc2014-06-22Not applicableUs
Anti-bacterial Wash With Exfoliating Beads for Blemish SkinGel25 mg/mLTopicalAllure Labs, Inc.2010-01-01Not applicableUs
BenoxylLotion5 %TopicalGlaxosmithkline Inc1968-12-312013-12-02Canada
Benoxyl 5% WashLiquid5 %TopicalStiefel Laboratories, Inc.1981-12-311998-07-09Canada
Benoxyl-CR Advanced Acne WashLiquid, extended release44 mg/mLTopicalElorac, Inc.2014-06-302015-12-29Us
BenzacSolution2.6 g/100mLTopicalGalderma2015-01-01Not applicableUs
Benzac Ac 5 Gel 5%Gel5 %TopicalGalderma1991-12-312016-08-04Canada
Benzac Acne Clearing CleanserGel2.6 %TopicalGaldermaNot applicableNot applicableCanada
Benzac W 5 Gel 5%Gel5 %TopicalGalderma1980-12-312016-08-04Canada
Benzac W Wash Lot 5%Lotion5 %TopicalGalderma1993-12-312016-08-04Canada
Benzagel 5 GelGel5 %TopicalColumbia Laboratories1996-08-29Not applicableCanada
Benzagel 5 Gel 5%Gel5 %TopicalRhone Poulenc Rorer1993-12-311997-08-13Canada
Benzagel 5 LotionLotion5 %TopicalColumbia Laboratories1996-12-31Not applicableCanada
Benzagel 5 WashLiquid5 %TopicalColumbia Laboratories1996-12-31Not applicableCanada
Benzagel 5 Wash 5%Liquid5 %TopicalRhone Poulenc Rorer1993-12-311997-08-13Canada
Benzagel Spot-ON Acne GelGel2.5 %TopicalColumbia Laboratories2011-08-22Not applicableCanada
BenzeproAerosol, foam3.18 g/60gTopicalPru Gen Pharmaceuticals2012-07-01Not applicableUs
BenzeproAerosol, foam9.8 g/100gTopicalPru Gen Pharmaceuticals2012-07-01Not applicableUs
Benzoyl PeroxideGel50 mg/gTopicalCintex Services, Llc2012-06-28Not applicableUs
Benzoyl PeroxideLiquid30 mg/mLTopicalPrasco, Laboratories2015-12-15Not applicableUs
Benzoyl PeroxideGel10 g/100gTopicalGeritrex Llc2014-01-09Not applicableUs
Benzoyl PeroxideLiquid50 mg/mLTopicalHarris Pharmaceutical, Inc.2011-11-18Not applicableUs
Benzoyl PeroxideGel100 mg/gTopicalTri Marc Labs2004-11-16Not applicableUs
Benzoyl PeroxideGel100 mg/gTopicalCintex Services, Llc2012-06-28Not applicableUs
Benzoyl PeroxideLiquid5 g/100gTopicalPerrigo New York Inc.2013-01-24Not applicableUs
Benzoyl PeroxideLiquid60 mg/mLTopicalPrasco, Laboratories2015-12-15Not applicableUs
Benzoyl PeroxideLiquid100 mg/mLTopicalHarris Pharmaceutical, Inc.2011-11-18Not applicableUs
Benzoyl PeroxideLiquid90 mg/mLTopicalPrasco, Laboratories2015-12-15Not applicableUs
Benzoyl PeroxideLiquid60 mg/mLTopicalHarris Pharmaceutical, Inc.2011-11-18Not applicableUs
Benzoyl PeroxideAerosol, foam53 mg/gTopicalCintex Services, Llc2011-03-04Not applicableUs
Benzoyl PeroxideGel10 g/100gTopicalMd Formulation.2001-09-23Not applicableUs
Benzoyl PeroxideGel2.5 g/100gTopicalPerrigo New York Inc.2012-03-13Not applicableUs
Benzoyl PeroxideLotion50 mg/gTopicalTri Marc Labs2004-11-16Not applicableUs
Benzoyl PeroxideKitTopicalWalmart Stores2010-02-26Not applicableUs
Benzoyl PeroxideLiquid10 g/100gTopicalPerrigo New York Inc.2013-02-20Not applicableUs
Benzoyl PeroxideAerosol, foam98 mg/gTopicalCintex Services, Llc2011-03-04Not applicableUs
Benzoyl PeroxideGel5 g/100gTopicalPerrigo New York Inc.2012-03-13Not applicableUs
Benzoyl PeroxideLotion100 mg/gTopicalTri Marc Labs2004-11-16Not applicableUs
Benzoyl PeroxideGel10 g/100gTopicalPerrigo New York Inc.2012-04-06Not applicableUs
Benzoyl PeroxideGel50 mg/gTopicalTri Marc Labs2004-11-16Not applicableUs
Benzoyl Peroxide 10% GelGel100 mg/gTopicalAxia Medical Solutions, Llc2014-10-01Not applicableUs
Benzoyl Peroxide Acne Treatment 5%Lotion5.0 %TopicalJan Marini Skin Research Inc2012-06-26Not applicableCanada
Benzoyl Peroxide Acne Treatment 5%Gel5 %TopicalCrls2014-10-24Not applicableCanada
Benzoyl Peroxide Acne Treatment Wash 2.5%Solution2.5 %TopicalJan Marini Skin Research Inc2013-01-07Not applicableCanada
Benzoyl Peroxide CleanserGel35 mg/gTopicalPharmco Laboratories Inc.2016-12-01Not applicableUs
Benzoyl Peroxide EmollientAerosol, foam53 mg/gTopicalTAGI Pharma, Inc.2013-10-11Not applicableUs
Benzoyl Peroxide EmollientAerosol, foam98 mg/gTopicalTAGI Pharma, Inc.2013-10-11Not applicableUs
Benzoyl Peroxide LotionLotion5 %TopicalPharmascience IncNot applicableNot applicableCanada
BevolineLotion2.5 g/100mLTopicalSkin Divine Inc.2015-10-012016-03-01Us
BevolineLotion2.5 g/100mLTopicalSkin Divine Inc.2015-10-012015-12-29Us
BevolineLotion2.5 g/100mLTopicalSkin Divine Inc.2016-02-22Not applicableUs
Bio-scriptives RepidermCream3.29 g/56gTopicalBio Chemics, Inc.2010-07-24Not applicableUs
Bioelements Breakout ControlCream2.5 mL/100mLTopicalBioelements2009-01-01Not applicableUs
BlemishGel50 mg/mLTopicalKamins Dermatologics Inc.2010-10-19Not applicableUs
BlemishGel100 mg/mLTopicalKamins Dermatologics Inc.2010-10-19Not applicableUs
Blemish Correcting SerumGel5 g/100mLTopicalCEN BEAUTY LLC2013-02-21Not applicableUs
Blemish Gel 5%Gel5.0 %TopicalKamins Dermatologics Inc.2004-07-17Not applicableCanada
Bp CleanserEmulsion42.5 mg/mLTopicalBiocomp Pharma, Inc.2012-03-012016-12-06Us
Bp CleansingLotion40 mg/gTopicalBiocomp Pharma, Inc.2012-03-012016-12-06Us
Bp Gel 5.5%Gel55 mg/gTopicalLaydan Labs, Llc2015-10-28Not applicableUs
Bp WashEmulsion50 mg/gTopicalCintex Services, Llc2011-12-15Not applicableUs
Bp WashEmulsion100 mg/gTopicalCintex Services, Llc2012-01-15Not applicableUs
Bp WashEmulsion25 mg/gTopicalCintex Services, Llc2011-08-15Not applicableUs
Bp WashEmulsion70 mg/mLTopicalCintex Services, Llc2011-01-15Not applicableUs
Bp WashEmulsion52.5 mg/gTopicalBiocomp Pharma, Inc.2012-03-012016-12-06Us
Bp Wash Acne Treatment PackKitCintex Services, Llc2011-09-012016-12-06Us
Bp Wash Acne Treatment PackKitCintex Services, Llc2011-09-012016-12-06Us
BpoGel4 mg/100mgTopicalAcella Pharmaceuticals, LLC2009-01-01Not applicableUs
BpoGel8 mg/100mgTopicalAcella Pharmaceuticals, LLC2009-01-01Not applicableUs
Bpo 5% CleanserSolution5 %TopicalPhysicians Care Alliance Llc2013-06-01Not applicableCanada
Bpo Creamy Wash Complete PackKitAcella Pharmaceuticals, LLC2011-09-27Not applicableUs
Bpo Creamy Wash Complete PackKitAcella Pharmaceuticals, LLC2009-08-19Not applicableUs
Bpo5 Acne Treatment GelGel5 %TopicalRejudicare Synergy Ltd2014-03-06Not applicableCanada
Breakout Clearing Daytime TreatmentLotion25 mg/mLTopicalDermalogica2013-06-04Not applicableUs
Breakout Clearing Emergency Spot FixLotion50 mg/mLTopicalDermalogica2013-06-03Not applicableUs
Breakout Control Acne TreatmentLotion5 mL/100mLTopicalBioelements2012-03-26Not applicableUs
Breakout Control BioelementsCream5 g/100mLTopicalBioelements2013-06-14Not applicableUs
Breakout Control BioelementsCream5 g/100mLTopicalCosmetic Enterprises2013-06-14Not applicableUs
CaradermaCream1.125 g/15gTopicalA Refreshing Discovery, Inc.2010-09-02Not applicableUs
Cetaphil Acne PrinciplesGel5.00 %TopicalGalderma2007-08-082014-07-15Canada
Clarifying Acne Vanishing TreatmentLotion2.5 %TopicalThe Mentholatum Company1994-12-312016-06-03Canada
Clean & Clear Advantage Foam Acne MedicationAerosol2.5 %TopicalJohnson & JohnsonNot applicableNot applicableCanada
Clean & Clear Advantage Plus 3-IN-1 CleanserCream5.0 %TopicalJohnson & Johnson2011-01-17Not applicableCanada
Clean & Clear Persa-gel 5Lotion5 %TopicalJohnson & Johnson2000-03-31Not applicableCanada
Clean and Clear Advantage 3 In 1 ExfoliatingCream50 mg/gTopicalJohnson & Johnson2014-07-01Not applicableUs
Clean and Clear Advantage 3 In 1 ExfoliatingCream50 mg/gTopicalJohnson & Johnson2014-07-012018-10-01Us
Clean and Clear Advantage 3-IN-1 Exfoliating CleanserLiquid5.57 mg/gTopicalJohnson & Johnson Consumer Products Company, Division Of Johnson Consumer Companies, Inc.2010-03-012016-02-01Us
Clean and Clear Advantage Acne ControlKitJohnson & Johnson2015-11-05Not applicableUs
Clean and Clear Advantage Acne Control CleanserCream50 mg/gTopicalJohnson & Johnson2015-10-01Not applicableUs
Clean and Clear Advantage Acne Targeting TreatmentGel2.5 %TopicalJohnson & JohnsonNot applicableNot applicableCanada
Clean and Clear Advantage Fast Acting TreatmentGel25 mg/gTopicalJohnson & Johnson2015-10-01Not applicableUs
Clean and Clear Continuous Control Acne CleanserCream100 mg/gTopicalJohnson & Johnson2010-01-202018-10-01Us
Clean and Clear Continuous Control Acne CleanserCream100 mg/gTopicalJohnson & Johnson Consumer Products Company, Division Of Johnson Consumer Companies, Inc.2015-06-24Not applicableUs
Clean and Clear Persa-gel 10Gel100 mg/gTopicalJohnson & Johnson2009-11-01Not applicableUs
Clean and Clear Persa-gel 10Gel100 mg/gTopicalJohnson & Johnson2011-06-01Not applicableUs
Cleanser Acne Clearing TreatmentLiquid.006 mg/.024mgTopicalCare Pluss Pharma S.A. De C.V.2012-08-06Not applicableUs
Clear Acne TreatmentCream2.5 %TopicalDermatological Solutions Inc2004-03-282007-06-20Canada
Clear Acne Treatment CreamCream5.0 %TopicalDermatological Solutions Inc2007-09-142011-08-23Canada
Clear Cell Medicated Acne Facial ScrubLiquid3 %TopicalImage Internationalmanufacturing Inc.Not applicableNot applicableCanada
Clear Cell Medicated Acne LotionLotion5 %TopicalImage Internationalmanufacturing Inc.Not applicableNot applicableCanada
Clear Cell Medicated Acne ScrubCream30 mg/mLTopicalAllure Labs, Inc.2010-01-01Not applicableUs
Clear Daily Skin Clearing Treatment 2.5% Benzoyl Peroxide Regular StrengthLotion2.5 %TopicalPaula's Choice, IncNot applicableNot applicableCanada
Clear Daily Skin Clearing Treatment 5% Benzoyl Peroxide Extra StrengthLotion5 %TopicalPaula's Choice, IncNot applicableNot applicableCanada
Clear Pore On-the Spot Acne Treatment, VanishingLotion2.5 %TopicalJohnson & Johnson1999-07-312009-08-06Canada
Clear Pore On-the Spot Acne Treatment,tintedLotion2.5 %TopicalJohnson & Johnson1999-07-312006-08-02Canada
Clear Proof Acne Treatment Acne MedicationGel5 g/100gTopicalMary Kay Inc.2012-06-15Not applicableUs
Clear Skin Treatment Repairing LotionLiquid3.7 %TopicalValeant Canada Lp Valeant Canada S.E.C.2005-10-092016-07-08Canada
Clear ZitCream100 mg/gTopicalSheffield Pharmaceuticals, Llc2003-02-03Not applicableUs
Clear Zone Acne System Skin Purifying MoisturizerLotion3.5 %TopicalGuthy Renker, Llc.2005-04-302009-08-05Canada
Clear Zone Acne System Skin Purifying WashLiquid3.5 %TopicalGuthy Renker, Llc.2005-04-302009-08-05Canada
Clearasil Bp Plus Skin Tone Crm 5%Cream5 %TopicalRichardson Vicks, Division Of The Procter & Gamble Company1984-12-312001-07-30Canada
Clearasil Daily Clear Acne Treatment Cream Bp PlusCream5 %TopicalReckitt Benckiser1982-12-31Not applicableCanada
Clearasil Daily Clear Tinted Acne TreatmentCream10 g/100gTopicalReckitt Benckiser2011-09-01Not applicableUs
Clearasil Daily Clear Vanishing Acne TreatmentCream10 g/100gTopicalReckitt Benckiser2011-09-01Not applicableUs
Clearasil Ultra Rapid Action TreatmentCream10 g/100gTopicalReckitt Benckiser2016-06-15Not applicableUs
Clearasil Ultra Rapid Action Vanishing TreatmentCream10 g/100gTopicalReckitt Benckiser2011-07-30Not applicableUs
Clearasil Ultra Tinted Rapid Action TreatmentCream10 g/100gTopicalReckitt Benckiser2009-08-042016-04-05Us
Clearz - ItLotion5 %TopicalFlageoli Limited1998-06-152008-08-26Canada
Clearz-ITCream5.0 %TopicalFlageoli LimitedNot applicableNot applicableCanada
Clenziderm Acne Therapeutic SystemKit; Lotion5 %TopicalObagi Medical Products, Inc., A Division Of Valeant Pharmaceuticals North America Llc.2015-08-25Not applicableCanada
Clenziderm Normal To Dry Skin/ Peau Normale à SècheKit; Lotion5 %TopicalValeant Groupe Cosmederme IncNot applicableNot applicableCanada
Clenziderm TherapeuticLotion50 mg/mLTopicalOMP, INC.2007-07-01Not applicableUs
Clenziderm TherapeuticLotion50 mg/mLTopicalValeant Pharmaceuticals North America2015-03-02Not applicableUs
Clinique Acne Solutions All-over Clearing TreatmentLotion2.5 %TopicalClinique Laboratories Dist2007-07-03Not applicableCanada
Clinique Acne Solutions Emergency LotionLotion5.0 %TopicalClinique Laboratories Dist2007-07-032015-07-30Canada
Clinique Skin Supplies for Men Acne Solutions Emergency LotionLotion5.0 %TopicalClinique Laboratories Dist2009-12-012011-07-27Canada
Complexion Clear Acne Treatment RejuvenatingCream25 mg/mLTopicalResults RNA, LLC2012-11-07Not applicableUs
Continuous Control Acne CleanserLotion5 %TopicalJohnson & Johnson2001-08-01Not applicableCanada
Continuous Control Acne Cleanser Image EssentialsCream10 g/100mLTopicalKmart Corporation2011-03-10Not applicableUs
Controlling CreamCream.8 mg/29.6mgTopicalCa Botana International2014-11-09Not applicableUs
Coral Actives 2 Step Acne Treatment SystemGel61.62 mg/mLTopicalPrime Enterprises, Inc.2013-03-12Not applicableUs
Crmy Acne Wash CvsCream4 g/100gTopicalCvs Health2014-11-26Not applicableUs
Cvs Acne Cleansing BarSoap100 mg/gTopicalCvs Health2016-01-01Not applicableUs
Cvs Health Acne Control Cleanser Acne MedicationLotion100 mg/gTopicalCvs Health2014-01-01Not applicableUs
Cvs Health Maximum Strength Acne Treatment Acne MedicationGel100 mg/mLTopicalCvs Health2014-01-01Not applicableUs
Daily Acne Control CleanserCream104 mg/10gTopicalKroger2014-08-18Not applicableUs
Daily Acne Control CleanserCream104 mg/10gTopicalWalgreen2016-03-01Not applicableUs
Daily Acne WashCream5 %TopicalRodan & FieldsNot applicableNot applicableCanada
Ddf Benzoyl Peroxide Acne TreatmentGel50 mg/gTopicalProcter And Gamble2008-05-012016-10-01Us
Deep Pore Acne Vanishing TreatmentLotion5 %TopicalThe Mentholatum Company1998-07-15Not applicableCanada
Dermaclear Spot TreatmentCream100 mg/gTopicalAllure Labs, Inc.2015-05-05Not applicableUs
Dermalogica Special Clearing BoosterLotion5 %TopicalDermalogica2002-05-302013-02-25Canada
Dermisa Clear SkinCream5 g/100gTopicalMontani Cosmetics Inc2013-02-28Not applicableUs
Dermoxyl Aqua Gel 2.5%Gel2.5 %TopicalIcn Pharmaceuticals1992-12-312005-04-26Canada
Dermoxyl Aqua Gel 5%Gel5 %TopicalIcn Pharmaceuticals1986-12-312005-04-26Canada
Dermoxyl Gel 2.5%Gel2.5 %TopicalIcn Pharmaceuticals1978-12-312005-04-26Canada
Dermoxyl Gel 5%Gel5 %TopicalIcn Pharmaceuticals1977-12-312005-04-26Canada
Desquam-X Gel 5%Gel5 %TopicalWestwood Squibb, Division Of Bristol Myers Squibb Canada Inc.1992-12-312004-08-05Canada
Desquam-X WashSolution5 mg/gTopicalRanbaxy Inc.2011-04-26Not applicableUs
Desquam-X WashSolution10 mg/gTopicalRanbaxy Inc.2011-04-26Not applicableUs
Desquam-X Wash Lot 5%Lotion5 %TopicalWestwood Squibb, Division Of Bristol Myers Squibb Canada Inc.1991-12-312006-02-10Canada
Dr Song AcneGel100 mg/gTopicalSecret by Nature Llc2015-12-01Not applicableUs
Dr Song AcneGel25 mg/gTopicalSecret by Nature Llc2015-12-01Not applicableUs
Dr. Lin Skincare AcneLotion2.5 g/100mLTopicalDr. Lin Skincare2013-06-26Not applicableUs
Dual Intensive Acne TreatmentGel; Lotion2.5 %TopicalRodan & Fields2015-02-02Not applicableCanada
Dual-shave 2 In 1Lotion5 g/100gTopicalLamden, Nisan2017-03-06Not applicableUs
Emergency Acne Vanishing Facial CleanserLotion5 %TopicalThe Mentholatum Company2009-06-02Not applicableCanada
Emergency Acne Vanishing Treatment WipesCloth2.5 %TopicalThe Mentholatum Company2013-07-302016-06-03Canada
Equate Beauty Acne Cleansing BarSoap100 mg/gTopicalWalmart Stores2017-05-17Not applicableUs
Equate Clear Complexion Facial CleanserLiquid100 mg/mLTopicalWalmart Stores2016-12-14Not applicableUs
Equate Maximum Strength Spot TreatmentGel135 mg/gTopicalWalmart Stores2010-07-13Not applicableUs
Equate Purifying CleanserGel25 mg/mLTopicalWalmart Stores2011-10-10Not applicableUs
Equate Purifying CleanserLiquid3 g/120gTopicalWalmart Stores2017-02-02Not applicableUs
Equate RepairingLotion1.5 g/60gTopicalWalmart Stores2017-02-03Not applicableUs
Equate RepairingLotion25 mg/mLTopicalWalmart Stores2011-10-10Not applicableUs
Family Care Acne TreatmentCream10 g/100gTopicalUnited Exchange Corporation2012-02-07Not applicableUs
Family Dollar Acne TreatmentCream10 g/100gTopicalFamily Dollar2012-01-20Not applicableUs
Foaming Acne Face Wash WalgreensCream10 g/100gTopicalWalgreens2013-02-15Not applicableUs
Formulab Treat for Adult AcneCream4 %TopicalFormulab Inc.2011-06-292014-08-26Canada
Formulab Treat for Young Adult AcneCream4 %TopicalFormulab Inc.2011-05-152014-08-26Canada
Gel-creme Acne Bpo Gel-cream 5%Cream5 %TopicalLaboratoires Dermo Cosmetik2014-02-202016-07-14Canada
Glytone AcneGel5.6 g/56gTopicalGenesis2010-03-01Not applicableUs
Glytone Acne 3pGel3 mL/60mLTopicalGenesis2010-10-15Not applicableUs
Glytone Acne Bpo Clearing CleanserLotion45 mg/mLTopicalGenesis2017-03-01Not applicableUs
Gmc Medical Acne-bpoGel51.9 mg/100mLTopicalLaboratoires Dermo Cosmetik2014-02-10Not applicableUs
Gnp Acne TreatmentCream10 g/100gTopicalAmerisource Bergen2013-06-30Not applicableUs
Good Neighbor Pharmacy Acne TreatmentCream10 g/100gTopicalTAI GUK PHARM. CO., LTD.2010-11-17Not applicableUs
H2 Oxyl 5%Cream5 %TopicalStiefel Laboratories, Inc.1981-12-311998-07-09Canada
H2oxyl 2.5%Cream2.5 %TopicalStiefel Laboratories, Inc.1981-12-311998-07-09Canada
Humane Acne WashCream100 mg/mLTopicalHumane Consumer, Llc2015-05-28Not applicableUs
Iblanc Restora-bright Acne HealingCream5.3 g/100gTopicalI Blanc, Inc.2012-08-01Not applicableUs
Iman Perfect Response Blemish GelGel5 %TopicalJohnson & JohnsonNot applicableNot applicableCanada
Intensive Face and Body Acne TreatmentGel10 g/100mLTopicalDr. Lin Skincare2014-07-11Not applicableUs
Invisible Acne Well At WalgreensCream10 g/100gTopicalWalgreens2013-02-15Not applicableUs
Johnson's Clean & Clear Persa-gelLotion5 %TopicalJohnson & Johnson1997-06-132003-08-25Canada
Kaiser Permanente Benzoyl PeroxideGel10 g/100gTopicalKaiser Foundations Hospitals2007-06-08Not applicableUs
Kaiser Permanente Benzoyl PeroxideLiquid10 g/100gTopicalKaiser Foundations Hospitals2007-06-08Not applicableUs
Kaiser Permanente Benzoyl PeroxideLiquid5 g/100gTopicalKaiser Foundations Hospitals2007-06-08Not applicableUs
Kaiser Permanente Benzoyl PeroxideGel5 g/100gTopicalKaiser Foundations Hospitals2007-06-08Not applicableUs
Kellett Clarifying Acne TreatmentGel5 %TopicalDermatological Solutions Inc2011-06-012016-08-11Canada
LA Roche Posay Laboratoire Dermatologique Effaclar Duo Acne TreatmentLotion55 mg/mLTopicalL'oreal2012-07-01Not applicableUs
LA Roche Posay Laboratoire Dermatologiqueeffaclar Duo Effaclar DuoLotion2.2 mg/40mLTopicalL'oreal2012-07-01Not applicableUs
Leader Maximum Strength Invisible AcneCream100 mg/gTopicalCardinal Health2008-06-01Not applicableUs
Let Me Be Perfectly ClearKitBiopelle, Inc.2011-04-01Not applicableUs
Loroxide Lotion 5%Lotion5 %TopicalRhone Poulenc Rorer1992-12-311998-08-12Canada
Mary Kay Acne Treatment Acne MedicationGel5 g/100gTopicalMary Kay Inc.1988-01-19Not applicableUs
MaskCream2.5 %TopicalTransdermal Corp.Not applicableNot applicableCanada
Maximum Strength Acne MedicationGel5 %TopicalFruit Of The Earth, Inc.2013-05-022015-08-06Canada
Meaningful Beauty Blemish TreatmentGel5 g/100gTopicalGuthy Renker, Llc.2016-04-30Not applicableUs
Medicated Acne GelGel5 %TopicalPrime Enterprises, Inc.2006-01-03Not applicableCanada
Medicated Pumice WashLotion2.5 g/100mLTopicalControl Corrective Skincare Inc2016-06-07Not applicableUs
Micronized Benzoyl Peroxide TreatmentGel25 mg/gTopicalPharmco Laboratories Inc.2012-06-01Not applicableUs
Micronized Benzoyl Peroxide TreatmentGel50 mg/gTopicalPharmco Laboratories Inc.2012-06-01Not applicableUs
Micronized Benzoyl Peroxide TreatmentGel100 mg/gTopicalPharmco Laboratories Inc.2012-06-01Not applicableUs
Micronized Bpo ScrubGel50 mg/gTopicalPharmco Laboratories Inc.2012-06-01Not applicableUs
Micronized Bpo WashGel50 mg/gTopicalPharmco Laboratories Inc.2012-06-01Not applicableUs
MyhelperCream5 g/100mLTopicalmybody2012-04-24Not applicableUs
Nano CleanseCream5 g/100gTopicalSunrider Manufacturing L.P.2015-08-04Not applicableUs
Nature's Cure Acne TreatmentCream5 %TopicalNature's Cure Inc.2006-12-19Not applicableCanada
Neostrata Acne Clear Medicated TreatmentLotion5 %TopicalSanofi Consumer Health Inc Sanofi Sante Grand Public IncNot applicableNot applicableCanada
Neutracure RestoreCream50 mg/mLTopicalNeutracure2015-04-10Not applicableUs
Neutrogena Acne ControlLotion25 mg/mLTopicalJohnson & Johnson2014-03-14Not applicableUs
Neutrogena Acne Mask 5%Paste5 %TopicalProfessional Pharmaceutical Corp. / Corp. Pharmaceutique Professionnelle1992-12-311998-07-03Canada
Neutrogena Clear Pore Acne TreatmentCream50 mg/gTopicalNeutrogena Corporation2012-02-01Not applicableUs
Neutrogena Clear Pore Cleanser MaskGel35 mg/mLTopicalJohnson & Johnson2016-04-01Not applicableUs
Neutrogena Clear Pore Cleanser MaskLotion35 mg/mLTopicalJohnson & Johnson2011-07-27Not applicableUs
Neutrogena Clear Pore Cleanser MaskGel3.5 %TopicalJohnson & Johnson2002-07-292005-08-09Canada
Neutrogena Clear Pore Daily ScrubSuspension37 mg/mLTopicalJohnson & Johnson2015-12-07Not applicableUs
Neutrogena Clear Pore Daily ScrubCream37 mg/mLTopicalJohnson & Johnson2010-12-01Not applicableUs
Neutrogena On-the-spot Acne Treat. 2.5% (also Tinted Formula)Jelly2.5 %TopicalProfessional Pharmaceutical Corp. / Corp. Pharmaceutique Professionnelle1995-12-311998-07-03Canada
Neutrogena On-the-spot Acne Treatment Vanishing FormulaCream25 mg/gTopicalJohnson & Johnson2016-02-01Not applicableUs
Neutrogena On-the-spot Acne Treatment Vanishing FormulaCream2.5 mg/gTopicalJohnson & Johnson2010-10-01Not applicableUs
Neutrogena Rapid Clear Stubborn Acne CleanserLotion100 mg/mLTopicalJohnson & Johnson2014-12-012018-07-01Us
Neutrogena Rapid Clear Stubborn Acne CleanserLotion100 mg/mLTopicalJohnson & Johnson2014-12-01Not applicableUs
Neutrogena Rapid Clear Stubborn Acne SpotGel100 mg/gTopicalJohnson & Johnson2014-09-052018-06-01Us
Neutrogena Rapid Clear Stubborn Acne SpotGel100 mg/gTopicalJohnson & Johnson2014-09-05Not applicableUs
Neutrogena Rapid Clear Stubborn Daily Leave On MaskGel25 mg/gTopicalJohnson & Johnson2015-10-01Not applicableUs
Neutrogena Skinid Anti Acne TreatmentLiquid50 mg/mLTopicalNeutrogena Corporation2011-12-222015-12-29Us
Neutrogena* Acne Mask, Oil Absorbing Clay BasePaste5 %TopicalJohnson & Johnson1999-07-312002-08-02Canada
Nighttime ControlLotion.05 mL/mLTopicalCircadia By Dr Pugliese, Inc.2012-07-15Not applicableUs
Nugen Acne Solution Mattifying HydratorLotion2.5 %TopicalMakeup Artistry Stores IncNot applicableNot applicableCanada
Nujevi AcneCream2.5 g/100gTopicalCosmoceutical Research Center Inc2014-08-28Not applicableUs
ObagiLotion50 mg/mLTopicalYS PLUS CORPORATION2014-10-15Not applicableUs
Obagi Clenziderm Acne GelGel5 %TopicalObagi Medical Products, Inc., A Division Of Valeant Pharmaceuticals North America Llc.2008-01-282013-07-18Canada
Obagi Clenziderm Acne LotionLotion5.0 %TopicalObagi Medical Products, Inc., A Division Of Valeant Pharmaceuticals North America Llc.2008-12-15Not applicableCanada
ObliterateLotion5 g/100mLTopicalmybody2012-04-24Not applicableUs
Oc EightGel7 mg/gTopicalBiopelle, Inc.2011-04-01Not applicableUs
Oc8Gel7 mg/gTopicalFerndale Laboratories, Inc.2012-08-13Not applicableUs
Ocean Seas Dermatology Acne Treatment CleanserSolution2.5 g/100mLTopicalCoastal Carolinas Integrated Medicine2016-03-29Not applicableUs
Oil-free Acne CleanserLotion2.5 %TopicalValeant Canada Lp Valeant Canada S.E.C.2015-02-18Not applicableCanada
Oil-free Acne CleanserCream2.5 g/100gTopicalUniversity Medical Pharmaceuticals Corp2011-11-01Not applicableUs
Oil-free Acne TreatmentGel2.5 %TopicalJohnson & JohnsonNot applicableNot applicableCanada
Oil-free Acne Wash Cleanser MaskPaste3.5 %TopicalJohnson & Johnson2014-01-132016-08-04Canada
Overnight Acne ControlGel2.5 %TopicalJohnson & Johnson2014-10-30Not applicableCanada
Overnight Acne Control LotionLotion3.0 %TopicalJohnson & Johnson2005-07-112016-01-22Canada
Oxy 10 TintedLotion100 mg/gTopicalThe Mentholatum Company2015-07-01Not applicableUs
Oxy 10 VanishingLotion100 mg/gTopicalThe Mentholatum Company2015-07-01Not applicableUs
Oxy 5 Regular Strength Cover Up Crm 5%Cream5 %TopicalSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1994-12-311998-08-25Canada
Oxy 5 Regular Strength Vanishing Lot 5%Lotion5 %TopicalSmithkline Beecham Consumer Healthcare, Division Of Smithkline Beecham Inc.1994-12-311998-08-25Canada
Oxy 5 TintedLotion50 mg/gTopicalThe Mentholatum Company2015-07-01Not applicableUs
Oxy 5 VanishingLotion50 mg/gTopicalThe Mentholatum Company2015-07-01Not applicableUs
Oxy Acne EraserOintment5 %TopicalThe Mentholatum CompanyNot applicableNot applicableCanada
Oxy Face Wash Maximum AcitonLotion100 mg/mLTopicalThe Mentholatum Company2016-08-01Not applicableUs
Oxy Maximum Action Advanced Face WashCream100 mg/mLTopicalThe Mentholatum Company2013-01-152016-12-31Us
Oxy Maximum Action Advanced Face Wash SensitiveCream50 mg/mLTopicalThe Mentholatum Company2013-07-012016-12-01Us
Oxy Maximum Action Face WashLiquid100 mg/mLTopicalThe Mentholatum Company2012-07-012016-12-01Us
Oxy Maximum Action Face Wash SensitiveLiquid50 mg/mLTopicalThe Mentholatum Company2012-11-302016-12-02Us
Oxy Maximum Action Spot TreatmentCream100 mg/gTopicalThe Mentholatum Company2013-01-152017-01-31Us
Oxy Maximum Action Spot Treatment TintedCream100 mg/gTopicalThe Mentholatum Company2013-01-152016-10-13Us
Oxy Maximum Action Treatment PadsSwab25 mg/1TopicalThe Mentholatum Company2013-01-152016-10-13Us
Oxy On-the-GO Acne StickStick50 mg/gTopicalThe Mentholatum Company2016-12-05Not applicableUs
Oxy Rapid Spot Treatment Maximum ActionCream100 mg/gTopicalThe Mentholatum Company2015-01-01Not applicableUs
Oxy Rapid Treatment Face Wash Maximum ActionCream100 mg/mLTopicalThe Mentholatum Company2015-01-01Not applicableUs
Oxy Rapid Treatment Face Wash Sensitive Skin Maximum ActionCream50 mg/mLTopicalThe Mentholatum Company2015-01-01Not applicableUs
Oxy Sensitive Face Wash Maximum SoothingLotion50 mg/mLTopicalThe Mentholatum Company2016-08-01Not applicableUs
Oxyderm Lotion 5%Lotion5 %TopicalValeant Canada Lp Valeant Canada S.E.C.1979-12-312014-07-30Canada
PanoxylCream30 mg/gTopicalStiefel Laboratories, Inc.2014-04-08Not applicableUs
PanoxylCream58.7 mg/gTopicalStiefel Laboratories, Inc.2011-03-25Not applicableUs
PanoxylSoap5.65 g/1TopicalPhysicians Total Care, Inc.2008-03-31Not applicableUs
PanoxylSoap1 g/10gTopicalStiefel Laboratories, Inc.2010-11-10Not applicableUs
PanoxylSoap11.3 g/1TopicalPhysicians Total Care, Inc.2008-03-31Not applicableUs
PanoxylSoap.5 g/10gTopicalStiefel Laboratories, Inc.2010-11-102015-12-29Us
PanoxylCream146.7 mg/gTopicalStiefel Laboratories, Inc.2011-03-25Not applicableUs
Panoxyl 5 BarSoap5 %TopicalGlaxosmithkline Inc1981-12-312015-07-03Canada
Panoxyl 5 GelGel5 %TopicalGlaxosmithkline Inc1973-12-312012-04-02Canada
Panoxyl Aquagel 2.5%Gel2.5 %TopicalGlaxosmithkline Inc1997-01-202012-02-27Canada
Panoxyl Aquagel 5%Gel5 %TopicalGlaxosmithkline Inc1997-01-202012-07-03Canada
Panoxyl Creamy Wash 4%Liquid4 %TopicalGlaxosmithkline Inc2001-09-222011-12-22Canada
Panoxyl Wash 5% - LotLotion5 %TopicalGlaxosmithkline Inc1997-01-202015-04-02Canada
Pca Skin AcneCream5 g/100gTopicalPhysicians Care Alliance dba PCA Skin2010-04-01Not applicableUs
Pca Skin Bpo CleanserGel5 g/100mLTopicalPhysicians Care Alliance dba PCA Skin2010-04-01Not applicableUs
Phisoderm Clear Confidence Spot TreatmentCream25 mg/gTopicalThe Mentholatum Company2013-08-01Not applicableUs
Proactiv Advanced Blemish TreatmentCream.06 g/gTopicalGuthy Renker, Llc.1999-01-01Not applicableUs
Proactiv Emergency Blemish ReliefCream5 g/100gTopicalThe Proactiv Company, Llc2017-03-09Not applicableUs
Proactiv Extra Strength FormulaLotion7 mg/100mLTopicalGuthy Renker, Llc.2003-12-01Not applicableUs
Proactiv Extra Strength Formula CleanserCream7 mg/100mLTopicalGuthy Renker, Llc.2003-12-01Not applicableUs
Proactiv Plus Emergency Blemish ReliefCream5 g/100gTopicalGuthy Renker, Llc.2013-02-15Not applicableUs
Proactiv Plus Pore Targeting TreatmentGel2.5 mg/100mLTopicalGuthy Renker, Llc.2013-01-03Not applicableUs
Proactiv Renewing CleanserCream.25 g/1000mLTopicalGuthy Renker, Llc.2009-01-01Not applicableUs
Proactiv Renewing CleanserGel2.5 g/100mLTopicalThe Proactiv Company, Llc2017-03-07Not applicableUs
Proactiv Renewing CleanserCream.025 g/1000mLTopicalGuthy Renker, Llc.2010-01-01Not applicableUs
Proactiv Renewing CleanserCream.025 g/1000mLTopicalGuthy Renker, Llc.2010-08-01Not applicableUs
Proactiv RepairingLotion2.5 mg/100mLTopicalGuthy Renker, Llc.2007-10-25Not applicableUs
Proactiv Repairing TreatmentLotion2.5 mg/100mLTopicalGuthy Renker, Llc.2009-03-30Not applicableUs
Proactiv Repairing TreatmentGel2.5 mg/100mLTopicalThe Proactiv Company, Llc2017-03-10Not applicableUs
Proactiv Repairing TreatmentLotion2.5 mg/100mLTopicalGuthy Renker, Llc.2010-09-01Not applicableUs
Proactiv Solution Advanced Blemish TreatmentCream5 %TopicalThe Proactiv Company Llc2006-04-01Not applicableCanada
Proactiv Solution Renewing CleanserGel2.5 mg/100mLTopicalThe Proactiv Company, Llc2011-10-21Not applicableUs
Proactiv Solution Renewing CleanserLotion2.5 mL/100mLTopicalGuthy Renker, Llc.2012-02-01Not applicableUs
Proactiv Solution Repairing TreatmentGel2.5 mg/100mLTopicalGuthy Renker, Llc.2013-11-01Not applicableUs
Proactiv Solution Repairing TreatmentGel2.5 mL/100mLTopicalGuthy Renker, Llc.2011-11-01Not applicableUs
Proactivplus Skin Smoothing ExfoliatorLotion2.5 mg/100mLTopicalGuthy Renker, Llc.2013-01-25Not applicableUs
Pure Pefection Classic Replenishing CleanserCream2.5 %TopicalKoolatron Corporation2003-10-252013-08-21Canada
Pure Perfection Classic Renewing CremeCream2.5 %TopicalKoolatron Corporation2003-10-252013-08-21Canada
Purifying CleanserSolution2.5 %TopicalValeant Canada Lp Valeant Canada S.E.C.2009-02-092016-07-08Canada
Redness Relief Neutralizing LotionLotion3 %TopicalUniversity Medical Pharmaceuticals CorpNot applicableNot applicableCanada
ReformCream52.5 mg/mLTopicalSchweiger Dermatology Group2017-01-01Not applicableUs
Rejuvenating Acne CreamCream2.5 %TopicalTransdermal Corp.Not applicableNot applicableCanada
RelovoxEmulsion25 mg/gTopicalTransdermal Corp.2011-03-31Not applicableUs
Renewal CleanserLotion2.5 %TopicalFruit Of The Earth, Inc.2015-12-10Not applicableCanada
Renewing CleanserLotion2.5 %TopicalTransdermal Corp.Not applicableNot applicableCanada
Repair LotionLotion5.0 %TopicalValeant Canada Lp Valeant Canada S.E.C.2010-06-182016-07-08Canada
Repairing TreatmentLotion2.5 %TopicalGuthy Renker, Llc.2011-06-012014-07-16Canada
Repairing TreatmentLotion2.5 %TopicalFruit Of The Earth, Inc.2015-12-10Not applicableCanada
Reversion Acne Control Spot Treatment PMLiquid7.5 mL/100mLTopicalTherapon Skin Health, LP2012-09-07Not applicableUs
Revitol Acne TreatmentCream2.95 mL/59mLTopicalRevitol Corporation2011-04-14Not applicableUs
RiaxAerosol, foam55 mg/gTopicalArtesa Labs, Llc2011-08-15Not applicableUs
RiaxAerosol, foam95 mg/gTopicalArtesa Labs, Llc2011-08-15Not applicableUs
Rodan & Fields Proactiv + Emergency Blemish ReliefCream5 %TopicalThe Proactiv Company Llc2014-10-27Not applicableCanada
Rodan & Fields Proactiv + Pore Targeting SolutionGel2.5 %TopicalThe Proactiv Company Llc2014-06-20Not applicableCanada
Rodan & Fields Proactiv + Skin Smoothing ExfoliatorGel2.5 %TopicalThe Proactiv Company Llc2014-06-20Not applicableCanada
Rodan & Fields Proactiv Solution CleanseGel2.5 %TopicalThe Proactiv Company Llc2013-08-08Not applicableCanada
Rodan & Fields Proactiv Solution TreatGel2.5 %TopicalThe Proactiv Company Llc2013-08-08Not applicableCanada
Rodan & Fields/proactiv Solution: Renewing CleanserLotion2.50 %TopicalGuthy Renker, Llc.2003-01-302014-07-16Canada
Rodan & Fields/proactiv Solution: Repairing LotionLotion2.5 %TopicalGuthy Renker, Llc.2003-01-302014-07-16Canada
Rodan and Fields Unblemish - Acne MedicatedCream2.5 mL/100mLTopicalCosmetic Enterprises2009-01-01Not applicableUs
Rodan+fields UnblemishCream; Gel; Kit; Lotion2.5 %TopicalRodan & Fields2015-02-02Not applicableCanada
Rugby Benzoyl Peroxide Acne MedicationGel50 mg/mLTopicalRugby2015-01-20Not applicableUs
Rugby Benzoyl Peroxide Acne MedicationGel100 mg/mLTopicalRugby2015-01-20Not applicableUs
Rugby Benzoyl Peroxide Acne MedicationLotion50 mg/mLTopicalRugby2015-01-20Not applicableUs
Rugby Benzoyl Peroxide Acne MedicationGel100 mg/mLTopicalA S Medication Solutions2015-01-20Not applicableUs
Rugby Benzoyl Peroxide Acne MedicationLotion100 mg/mLTopicalRugby2015-01-20Not applicableUs
Rugby Benzoyl Peroxide Acne MedicationGel50 mg/mLTopicalA S Medication Solutions2015-01-20Not applicableUs
Safeway Acne TreatmentCream10 g/100gTopicalSafeway2012-06-06Not applicableUs
Serious Action Exfoliant WashLiquid2.5 %TopicalGlymed Plus CanadaNot applicableNot applicableCanada
Serious Action Skin Medication No. 5Lotion5 %TopicalGlymed Plus CanadaNot applicableNot applicableCanada
Serious Action Skin WashLiquid2.5 %TopicalGlymed Plus CanadaNot applicableNot applicableCanada
Shave CreamCream2.5 %TopicalThe Mentholatum Company2009-01-052011-08-04Canada
Skin Id Personalized Acne Solution Anti-acne TreatmentGel2.5 %TopicalJohnson & Johnson2009-11-232014-07-30Canada
Skin Id Personalized Acne Solution Cream Cleanser/maskPaste3.5 %TopicalJohnson & Johnson2009-11-232013-07-31Canada
Skin Pharmacy Advanced Acne Therapy Targeted Treatment WipesSwab25 mg/mLTopicalAmcol Health & Beauty Solutions, Inc. Dba2014-05-01Not applicableUs
Skinmedica Acne TreatmentLotion25 mg/gTopicalAllergan2013-01-01Not applicableUs
Skinpharmacy Advanced Acne Therapy Active ClearingLiquid25 mg/mLTopicalCvs Health2014-06-01Not applicableUs
Skinpharmacy Advanced Acne Therapy Spot TreatmentLiquid50 mg/mLTopicalCvs Health2014-06-01Not applicableUs
Skinpharmacy Advanced Acne Therapy Targeted Treatment WipesSwab25 mg/mLTopicalCvs Health2014-05-01Not applicableUs
Skintx Acne TreatmentLotion50 mg/mLTopicalVivier Pharma2011-11-01Not applicableUs
Slmd Am Benzoyl Peroxide Acne TreatmentGel2.5 g/100gTopicalOwen Biosciences, Inc.2017-03-22Not applicableUs
Slmd Spot TreatmentGel10 g/100gTopicalOwen Biosciences, Inc.2017-03-22Not applicableUs
SolugelGel4 %TopicalGlaxosmithkline Inc1992-12-312014-11-03Canada
Special Clearing BoosterLiquid50 mg/mLTopicalDermalogica2011-09-22Not applicableUs
Special Clearing Booster - Liq 5%Liquid5 %TopicalCalcorp 55 Enterprises (Canada) Inc.1996-02-292002-05-30Canada
Spectro Acnecare Deep Pore Vanishing LotionLotion5 %TopicalGlaxosmithkline Inc2004-10-052015-07-28Canada
Spectro Acnecare Spot TreatmentGel3 %TopicalGlaxosmithkline IncNot applicableNot applicableCanada
Spectro Acnecare Vanishing Lotion for Sensitive SkinLotion2.5 %TopicalGlaxosmithkline Inc2004-10-052014-07-28Canada
Spectro Acnecare Wash for Acne Prone SkinLotion4 %TopicalGlaxosmithkline Inc2014-07-10Not applicableCanada
Spot Clearing LotionGel2.5 %TopicalAlumier Europe Ltd2016-08-30Not applicableCanada
Stubborn Acne CleanserPaste3.5 %TopicalJohnson & Johnson2017-01-30Not applicableCanada
Stubborn Acne Daily Leave-ON MaskGel2.5 %TopicalJohnson & Johnson2016-01-18Not applicableCanada
Stubborn Acne Spot GelGel5 %TopicalJohnson & Johnson2016-01-18Not applicableCanada
Targeted Acne Spot Treatment CvsLotion2.5 g/100gTopicalCvs Health2014-11-26Not applicableUs
TerminatorCream5.0 %TopicalValeant Canada Lp Valeant Canada S.E.C.2015-02-18Not applicableCanada
TerminatorGel2.5 %TopicalValeant Canada Lp Valeant Canada S.E.C.2010-05-202014-09-02Canada
Terminator 5Cream5 %TopicalValeant Canada Lp Valeant Canada S.E.C.2010-04-072014-09-02Canada
Triple Action Acne Vanishing TreatmentCream5 %TopicalThe Mentholatum Company1998-07-152016-06-03Canada
Unblem EstCream100 mg/gTopicalElli Est2012-10-25Not applicableUs
UnblemishLotion50 mg/mLTopicalRodan & Fields2014-06-01Not applicableUs
Vanishing Acne CvsCream10 g/100gTopicalCvs Health2013-12-13Not applicableUs
Winco Foods Maximum Strength Acne TreatmentCream10 g/100gTopicalWin Co Foods, Llc,2014-12-01Not applicableUs
X Out Cleansing Wipes for On The Go Blemish TreatmentSwab2.75 mg/1TopicalGuthy Renker, Llc.2012-12-31Not applicableUs
X Out Wash-IN TreatmentGel5 %TopicalThe Proactiv Company LlcNot applicableNot applicableCanada
X-out Wash-IN TreatmentGel8.5 mg/100gTopicalGuthy Renker, Llc.2011-09-23Not applicableUs
Zap-IT Crm 5%Cream5 %TopicalMelaleuca, Inc.1994-12-311997-03-11Canada
Zitfree Acne TreatmentOintment100 mg/gTopicalNatureplex, LLC2014-12-01Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
BenzefoamAerosol, foam5.3 g/100gTopicalOnset Dermatologics, LLC2009-09-18Not applicableUs
Benzefoam UltraAerosol, foam9.8 g/100gTopicalOnset Dermatologics, LLC2011-03-04Not applicableUs
Benzepro Creamy WashSoap7 g/100gTopicalPru Gen Pharmaceuticals2015-07-01Not applicableUs
Benzoyl PeroxideLiquid2.5 g/100gTopicalPerrigo New York Inc.2008-02-08Not applicableUs
Benzoyl PeroxideLiquid10 g/100gTopicalPerrigo New York Inc.2008-05-192017-01-18Us
Benzoyl Peroxide Aqueous BaseGel2.5 g/100gTopicalPerrigo New York Inc.2008-09-242017-01-18Us
Benzoyl Peroxide EmollientAerosol, foam5.3 g/100gTopicalMetacon Labs2011-04-012016-03-31Us
Benzoyl Peroxide Short ContactAerosol, foam9.8 g/100gTopicalMetacon Labs2011-04-012017-02-28Us
Bpo 3 FoamingCloth3.2 g/100gTopicalAcella Pharmaceuticals, LLC2010-08-18Not applicableUs
Bpo 6 FoamingCloth3.2 g/100gTopicalAcella Pharmaceuticals, LLC2010-08-18Not applicableUs
Bpo 9 FoamingCloth9 g/100gTopicalAcella Pharmaceuticals, LLC2010-08-18Not applicableUs
Desquam-X WashSolution5 mg/mLTopicalRanbaxy Inc.2008-08-27Not applicableUs
Desquam-X WashSolution10 mg/mLTopicalRanbaxy Inc.2008-05-02Not applicableUs
Dr. Throwers Bpo 5Cream5 g/100gTopicalDr. Thrower's Skincare, Inc.2015-05-15Not applicableUs
Neobenz Micro Plus PackKitSkin Medica Pharmaceuticals, Inc.2009-04-16Not applicableUs
Pacnex HpCloth70 mg/gTopicalMedimetriks Pharmaceuticals2010-07-09Not applicableUs
Pacnex LpCloth42.5 mg/gTopicalMedimetriks Pharmaceuticals2010-07-09Not applicableUs
Perrigo Benzoyl Peroxide Aqueous BaseGel5 g/100gTopicalPerrigo New York Inc.2008-08-072017-01-18Us
Perrigo Benzoyl Peroxide Aqueous BaseGel10 g/100gTopicalPerrigo New York Inc.2008-12-042017-01-18Us
Perrigo Benzoyl Peroxide Hydroalcoholic BaseGel5 g/100gTopicalPerrigo New York Inc.2007-10-042017-01-18Us
Perrigo Benzoyl Peroxide Hydroalcoholic BaseGel5 g/100gTopicalRebel Distributors2007-10-04Not applicableUs
Perrigo Benzoyl Peroxide Hydroalcoholic BaseGel10 g/100gTopicalPerrigo New York Inc.2008-09-152017-01-18Us
Perrigo Benzoyl Peroxide WashLotion5 g/100gTopicalPerrigo New York Inc.2008-04-152017-01-26Us
Pr Benzoyl Peroxide WashLotion70 mg/mLTopicalPru Gen Pharmaceuticals2009-10-26Not applicableUs
Se BpoKitSeton Pharmaceuticals2010-10-042016-10-13Us
Topical CleanserSoap60 mg/gTopicalHarris Pharmaceutical, Inc.2010-11-18Not applicableUs
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
AcanyaValent Pharmaceuticals North America
Acne Clearning Treatment FaceCare Pluss Pharma S.A. De C.V.
Acne Treatment SystemVivier Canada Incorporated
Active Anti-acne Treatment KitFruit Of The Earth, Inc.
Advantage Acne Control KitJohnson & Johnson
AktipakCutanea Life Sciences, Inc.
BenzaclinPhysicians Total Care, Inc.
Benzaclin Topical GelValeant Canada Lp Valeant Canada S.E.C.
BenzamycinDermik Laboratories
Clean and Clear Advantage Acne ControlJohnson & Johnson
Clear Cell Medicated AcneAllure Labs, Inc.
Clear Proof Acne SystemMary Kay Inc.
Clear Proof Acne System The Go SetMary Kay Inc.
Clearasil Ultra Acne SystemReckitt Benckiser
Clearasil Ultra Fast Fix AcneReckitt Benckiser
Clearasil Ultra Rapid Action Acne SystemReckitt Benckiser
Clearasil Ultra Rapid Action Clear SkinReckitt Benckiser
Clease and TreatQuinnova Pharmaceuticals, Inc.
Clenziderm M.D. System Acne Therapeutic SystemValeant Pharmaceuticals North America
Clenziderm Normal To Dry Skin Acne Therapeutic SystemOMP, INC.
Clenziderm Normal To Oily Skin Acne Therapeutic SystemOMP, INC.
Clindamycin - Benzoyl PeroxidePrasco, Laboratories
Clindamycin and Benzoyl PeroxidePerrigo New York Inc.
Clindamycin Phosphate and Benzoyl PeroxideMylan Pharmaceuticals
Clindamycin Phosphate and Benzoyl PerxideOceanside Pharmaceuticals
Clindoxyl Adv GelGlaxosmithkline Inc
Clindoxyl GelGlaxosmithkline Inc
Complete Acne Therapy SystemJohnson & Johnson
Cvs Advance Acne Therapy KitDiversified Global Technologies, Llc
DuacStiefel Laboratories, Inc.
EpiduoGalderma
Epiduo ForteGalderma
Erythromycin and Benzoyl PeroxideLyne Laboratories, Inc.
Erythromycin-benzoyl PeroxidePerrigo New York Inc.
Gmc Medical Acne TreatmentLaboratoires Dermo Cosmetik
NeuacMedimetriks Pharmaceuticals
Neuac KitMedimetriks Pharmaceuticals
Neutrogena Complete Acne Therapy SolutionJohnson & Johnson
Neutrogena Complete Acne Therapy SystemNeutrogena Corporation
ObagiYS PLUS CORPORATION
OnextonValeant Pharmaceuticals North America
Paula's Choice Clear Anti-acne Extra Strength SystemPaula's Choice, Inc
Paula's Choice Clear Anti-acne Regular Strength SystemPaula's Choice, Inc
Persol Acne CreamCarter Horner Corp.
Persol Forte Acne CreamCarter Horner Corp.
Proactiv 3-step Acne Treatment SystemGuthy Renker, Llc.
Proactiv 3-step Convenience PakThe Proactiv Company Llc
Rodan & Fields Proactiv + Skin Smoothing Exfoliator, Pore Targeting Solution, Complexion Perfecting HydratorThe Proactiv Company Llc
Skin Pharmacy Advanced Acne Therapy KitAmcol Health & Beauty Solutions, Inc. Dba
Skinpharmacy Advanced Acne Therapy KitCvs Health
Skintx Acne Treatment SystemVivier Pharma
Stubborn Acne SolutionJohnson & Johnson
Sulfoxyl Lotion RegularStiefel Laboratories, Inc.
Super Bump ReliefElements Personal Care, Inc.
TactupumpGalderma
Tactupump ForteGalderma
Taro-clindamycin/benzoyl Peroxide GelTaro Pharmaceuticals, Inc.
Vanoxide HCSummers Laboratories
Categories
UNIIW9WZN9A0GM
CAS number94-36-0
WeightAverage: 242.2268
Monoisotopic: 242.057908808
Chemical FormulaC14H10O4
InChI KeyOMPJBNCRMGITSC-UHFFFAOYSA-N
InChI
InChI=1S/C14H10O4/c15-13(11-7-3-1-4-8-11)17-18-14(16)12-9-5-2-6-10-12/h1-10H
IUPAC Name
benzoyl benzenecarboperoxoate
SMILES
O=C(OOC(=O)C1=CC=CC=C1)C1=CC=CC=C1
Pharmacology
Indication

Benzoyl peroxide is indicated for the treatment of mild to moderate acne vulgaris and rosacea. Combined with other agents, it may be used in the treatment of more severe acne.

Structured Indications
Pharmacodynamics

Benzoyl peroxide acts as an antibacterial, irritant, keratolytic, comedolytic, and anti-inflammatory agent when applied topically to the human epithelium.

Mechanism of action

Benzoyl peroxide decomposes to release oxygen after topical application. This oxygen acts as a bactericidal agent towards Proprionibacterium acnes, the bacteria present in acne vulgaris. Benzoyl peroxide also increases the turnover rate of epithelial cells, thereby peeling the skin and promoting the resolution of comedones.

Related Articles
Absorption

Benzoyl peroxide is absorbed percutaneously into the dermal layer of the epithelium. It is then metabolized to benzoic acid which can be absorbed systemically. There is no systemic absorption of benzoyl peroxide itself.

Volume of distribution

Benzoyl peroxide is not absorbed or distributed systemically after topical application.

Protein binding

Benzoyl peroxide does not undergo protein binding as it is does not enter systemic circulation after topical application.

Metabolism

Benzoyl peroxide undergoes metabolism by keratinocytes in the epidermis. Initially, the peroxide bond is cleaved to form benzoyloxyl radicals. It is thought this reaction may be copper-catalyzed. The benzoyloxyl radicals may then fragment to form carbon dioxide and a phenyl radical. Alternatively, the radicals may gain a hydrogen atom from biomolecules forming the more stable and primary metabolite, benzoic acid.

SubstrateEnzymesProduct
Benzoyl peroxide
Not Available
Benzoyloxyl radicalDetails
Benzoyloxyl radical
Not Available
Benzoic acidDetails
Route of elimination

Renal clearance of the primary metabolite, benzoic acid, is rapid and thought to preclude hepatic conjugation.

Half life

Benzoyl peroxide is not absorbed into systemic circulation after topical application. Further studies are needed on its half life within the epithelium.

Clearance

Benzoyl peroxide is not absorbed into systemic circulation after topical application. Its primary metabolite, benzoic acid, is cleared rapidly via renal excretion and hepatic conjugation is thought to be bypassed.

Toxicity

There is no evidence to support carcinogenicity in humans. Benzoyl peroxide may cause contact hypersensitivity, stinging and burning sensations when applied topically. It should not be applied under occlusive dressings due to risk of sensitization. During processing and formulation, exposure to concentrations higher than 12.2 mg/cu may cause irritation to the nose and/or throat.

Affected organisms
  • Propionibacterium acnes
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
DapsoneThe risk or severity of adverse effects can be increased when Benzoyl peroxide is combined with Dapsone.Approved, Investigational
Food InteractionsNot Available
References
Synthesis Reference

1. Zenz, C. Occupational Medicine – Principles and Practical Applications. 2nd ed. St. Louis, MO: Mosby-Yearbook Inc.; 1988: 712.
2. Budavari, S. (ed.). The Merck Index – An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc.; 1996: 187.
3. Ashford, RD. Ashford’s Dictionary of Industrial Chemicals. London, England: Wavelength Publications Ltd.; 1994: 119.

General References
  1. Bojar RA, Cunliffe WJ, Holland KT: The short-term treatment of acne vulgaris with benzoyl peroxide: effects on the surface and follicular cutaneous microflora. Br J Dermatol. 1995 Feb;132(2):204-8. [PubMed:7888356 ]
  2. Kawashima M, Nagare T, Katsuramaki T: Open-label, randomized, multicenter, phase III study to evaluate the safety and efficacy of benzoyl peroxide gel in long-term use in patients with acne vulgaris: A secondary publication. J Dermatol. 2017 Feb 2. doi: 10.1111/1346-8138.13741. [PubMed:28150367 ]
  3. Francis NA, Entwistle K, Santer M, Layton AM, Eady EA, Butler CC: The management of acne vulgaris in primary care: a cohort study of consulting and prescribing patterns using the Clinical Practice Research Datalink. Br J Dermatol. 2017 Jan;176(1):107-115. doi: 10.1111/bjd.15081. Epub 2016 Dec 27. [PubMed:27716910 ]
  4. Rosamilia LL: Over-the-counter treatments for acne and rosacea. Semin Cutan Med Surg. 2016 Jun;35(2):87-95. doi: 10.12788/j.sder.2016.026. [PubMed:27416314 ]
  5. Yeung D, Nacht S, Bucks D, Maibach HI: Benzoyl peroxide: percutaneous penetration and metabolic disposition. II. Effect of concentration. J Am Acad Dermatol. 1983 Dec;9(6):920-4. [PubMed:6643790 ]
  6. Nacht S, Yeung D, Beasley JN Jr, Anjo MD, Maibach HI: Benzoyl peroxide: percutaneous penetration and metabolic disposition. J Am Acad Dermatol. 1981 Jan;4(1):31-7. [PubMed:7204686 ]
  7. Swauger JE, Dolan PM, Zweier JL, Kuppusamy P, Kensler TW: Role of the benzoyloxyl radical in DNA damage mediated by benzoyl peroxide. Chem Res Toxicol. 1991 Mar-Apr;4(2):223-8. [PubMed:1782351 ]
External Links
ATC CodesD10AE51D10AE01
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (37.4 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
0RecruitingTreatmentOsteomyelitis1
1CompletedPreventionAcne Vulgaris1
1CompletedTreatmentAcne Vulgaris6
2CompletedTreatmentAcne Vulgaris1
3CompletedTreatmentAcne4
3CompletedTreatmentAcne Vulgaris11
3Not Yet RecruitingTreatmentAcne Vulgaris1
3Unknown StatusTreatmentAcne Vulgaris2
4Active Not RecruitingPreventionAcne Vulgaris / Atrophic Acne Scars1
4Active Not RecruitingTreatmentAcne Vulgaris1
4CompletedNot AvailableAcne Vulgaris1
4CompletedNot AvailableP Acnes Colonization1
4CompletedTreatmentAcne1
4CompletedTreatmentAcne Vulgaris18
4CompletedTreatmentSkin Diseases1
4Unknown StatusTreatmentAcne Vulgaris1
4Unknown StatusTreatmentTreatment of Acne Vulgaris Grade II in a Short Period of Time1
Not AvailableCompletedNot AvailableAcne1
Not AvailableCompletedNot AvailableAcne Vulgaris1
Not AvailableCompletedTreatmentAcne Vulgaris8
Not AvailableRecruitingPreventionShoulder Infection1
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage forms
FormRouteStrength
SoapTopical100 mg/g
LiquidTopical
GelTopical5 mL/100mL
Shampoo, suspensionTopical25 mg/mL
GelTopical100 mg/g
LotionTopical100 mg/1000mL
GelTopical50 mg/g
LotionTopical50 mg/1000mL
CreamTopical10 g/100mL
LotionTopical30 mg/g
SolutionTopical5.0 %
GelTopical1 mg/g
GelTopical3.5 g/100mL
Kit; liquid; lotionTopical
CreamTopical25 mg/g
LiquidTopical4.25 g/170g
CreamTopical3.4 g/136g
LiquidTopical25 mg/mL
CreamTopical50 mg/g
Kit
LotionTopical10 mL/100mL
CreamTopical100 mg/g
Liquid, extended releaseTopical44 mg/mL
Aerosol, foamTopical2.5 g/100g
CreamTopical5.5 g/100mL
CreamTopical.026 mg/mg
CreamTopical1.4 g/28g
LotionTopical5 g/100mL
LotionTopical20 %
SolutionTopical2.6 g/100mL
GelTopical2.6 %
GelTopical10 %
GelTopical5 %
LotionTopical5 %
LiquidTopical5 %
GelTopical2.5 %
Kit
Aerosol, foamTopical5.3 g/100g
Aerosol, foamTopical9.8 g/100g
Aerosol, foamTopical3.18 g/60g
SoapTopical7 g/100g
Aerosol, foamTopical53 mg/g
Aerosol, foamTopical98 mg/g
KitTopical
LiquidTopical2.5 g/100g
LiquidTopical30 mg/mL
LiquidTopical60 mg/mL
LiquidTopical90 mg/mL
SolutionTopical2.5 %
GelTopical2.5 g/100g
GelTopical35 mg/g
CreamTopical3.29 g/56g
CreamTopical2.5 mL/100mL
GelTopical5 g/100mL
GelTopical5.0 %
EmulsionTopical42.5 mg/mL
LotionTopical40 mg/g
GelTopical55 mg/g
EmulsionTopical100 mg/g
EmulsionTopical25 mg/g
EmulsionTopical50 mg/g
EmulsionTopical52.5 mg/g
EmulsionTopical70 mg/mL
GelTopical4 mg/100mg
GelTopical8 mg/100mg
ClothTopical3.2 g/100g
SolutionTopical5 %
ClothTopical9 g/100g
LotionTopical5 mL/100mL
CreamTopical1.125 g/15g
GelTopical5.00 %
AerosolTopical2.5 %
CreamTopical5.0 %
LiquidTopical5.57 mg/g
LiquidTopical.006 mg/.024mg
LiquidTopical3 %
CreamTopical30 mg/mL
LiquidTopical3.7 %
LotionTopical3.5 %
LiquidTopical3.5 %
CreamTopical5 %
ClothTopical
Kit; lotionTopical5 %
LotionTopical50 mg/mL
LotionTopical2.5 %
Gel; kit; lotionTopical
CreamTopical25 mg/mL
CreamTopical.8 mg/29.6mg
GelTopical61.62 mg/mL
CreamTopical4 g/100g
CreamTopical104 mg/10g
GelTopical20 %
SolutionTopical10 mg/mL
SolutionTopical10 mg/g
SolutionTopical5 mg/mL
SolutionTopical5 mg/g
LotionTopical10 %
LotionTopical2.5 g/100mL
Gel; lotionTopical2.5 %
ClothTopical2.5 %
GelTopical
GelTopical135 mg/g
GelTopical25 mg/mL
LiquidTopical3 g/120g
LotionTopical1.5 g/60g
LotionTopical25 mg/mL
CreamTopical10 g/100g
CreamTopical4 %
GelTopical5.6 g/56g
GelTopical3 mL/60mL
LotionTopical45 mg/mL
GelTopical51.9 mg/100mL
CreamTopical10 %
CreamTopical20 %
CreamTopical2.5 %
CreamTopical5.3 g/100g
GelTopical10 g/100mL
GelTopical10 g/100g
GelTopical5 g/100g
LiquidTopical10 g/100g
LiquidTopical5 g/100g
LotionTopical55 mg/mL
LotionTopical2.2 mg/40mL
CreamTopical5 g/100mL
CreamTopical5 g/100g
KitTopical
PasteTopical5 %
GelTopical3.5 %
GelTopical35 mg/mL
LotionTopical35 mg/mL
CreamTopical37 mg/mL
SuspensionTopical37 mg/mL
JellyTopical2.5 %
CreamTopical2.5 mg/g
GelTopical25 mg/g
LotionTopical.05 mL/mL
LotionTopical5.0 %
GelTopical7 mg/g
SolutionTopical2.5 g/100mL
CreamTopical2.5 g/100g
LotionTopical3.0 %
LotionTopical100 mg/g
LotionTopical50 mg/g
OintmentTopical5 %
LiquidTopical100 mg/mL
LiquidTopical50 mg/mL
SwabTopical25 mg/1
StickTopical50 mg/g
CreamTopical100 mg/mL
CreamTopical50 mg/mL
ClothTopical70 mg/g
ClothTopical42.5 mg/g
CreamTopical146.7 mg/g
CreamTopical30 mg/g
CreamTopical58.7 mg/g
SoapTopical.5 g/10g
SoapTopical1 g/10g
SoapTopical11.3 g/1
SoapTopical5.65 g/1
SoapTopical10 %
SoapTopical5 %
LiquidTopical4 %
LiquidTopical10 %
Kit; lotion; solutionTopical
LotionTopical5 g/100g
LotionTopical70 mg/mL
Kit; lotionTopical
Gel; kitTopical
CreamTopical.06 g/g
LotionTopical7 mg/100mL
CreamTopical7 mg/100mL
CreamTopical.025 g/1000mL
CreamTopical.25 g/1000mL
GelTopical2.5 g/100mL
LotionTopical2.5 mg/100mL
LotionTopical2.5 mL/100mL
GelTopical2.5 mg/100mL
GelTopical2.5 mL/100mL
LotionTopical3 %
CreamTopical52.5 mg/mL
LiquidTopical7.5 mL/100mL
CreamTopical2.95 mL/59mL
Aerosol, foamTopical55 mg/g
Aerosol, foamTopical95 mg/g
LotionTopical2.50 %
Cream; gel; kit; lotionTopical2.5 %
GelTopical100 mg/mL
GelTopical50 mg/mL
LotionTopical100 mg/mL
LiquidTopical2.5 %
PasteTopical3.5 %
SwabTopical25 mg/mL
LotionTopical25 mg/g
GelTopical4 %
GelTopical8 %
GelTopical3 %
LotionTopical4 %
Gel; kit; pasteTopical
CreamTopical
LotionTopical2.5 g/100g
SoapTopical60 mg/g
LotionTopical
SwabTopical2.75 mg/1
GelTopical8.5 mg/100g
OintmentTopical100 mg/g
PricesNot Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7820186 No2005-11-232025-11-23Us
US7964202 No2004-09-012024-09-01Us
US8071644 No2007-07-182027-07-18Us
US8080537 No2007-07-182027-07-18Us
US8105618 No2002-12-232022-12-23Us
US8129362 No2007-07-182027-07-18Us
US8241649 No2002-12-232022-12-23Us
US8288434 No2009-08-052029-08-05Us
US8445543 No2007-07-122027-07-12Us
US8663699 No2009-06-032029-06-03Us
US8703820 No2003-03-122023-03-12Us
US8729127 No2003-03-122023-03-12Us
US8785420 No2002-12-232022-12-23Us
US8809305 No2002-12-232022-12-23Us
US8895070 No2009-06-032029-06-03Us
US8909305 No2002-12-232022-12-23Us
US8936800 No2002-12-232022-12-23Us
US9078870 No2009-06-032029-06-03Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point (°C)103 - 106 Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc.; 1996: 187.
boiling point (°C)Decomposes explosively above melting point. Does not reach boiling point.United States Department of Labor. OSHA Occupational Chemical Database. Occupational Safety and Health Administration website. https://www.osha.gov/chemicaldata/chemResult.html?RecNo=748. Accessed February 22, 2017.
water solubility<1%United States Department of Labor. OSHA Occupational Chemical Database. Occupational Safety and Health Administration website. https://www.osha.gov/chemicaldata/chemResult.html?RecNo=748. Accessed February 22, 2017.
Predicted Properties
PropertyValueSource
Water Solubility0.0294 mg/mLALOGPS
logP2.75ALOGPS
logP3.95ChemAxon
logS-3.9ALOGPS
pKa (Strongest Basic)-7.2ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area52.6 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity64.77 m3·mol-1ChemAxon
Polarizability24.16 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET featuresNot Available
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as benzoyl peroxides. These are organic compounds containing two benzoyl groups O-linked to each other via a peroxide group. Their skeleton has the general formula [C6H5C(O)]2O2.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassBenzoyl peroxides
Direct ParentBenzoyl peroxides
Alternative Parents
Substituents
  • Benzoyl peroxide
  • Peroxybenzoate
  • Benzoic acid or derivatives
  • Benzoyl
  • Dicarboxylic acid or derivatives
  • Peroxycarboxylic acid or derivatives
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External DescriptorsNot Available
Drug created on September 16, 2015 12:04 / Updated on May 29, 2017 03:59