Acne

Also known as: Acnes / Acne, unspecified / [X]Acne, unspecified / Acne NOS

DrugDrug NameDrug Description
DB09096Benzoyl peroxideBenzoyl peroxide (BPO) is an organic compound in the peroxide family. It consists of two benzoyl groups bridged by a peroxide link. It is one of the most important organic peroxides in terms of applications. In medicine, benzoyl peroxide is used as a topical treatment for acne, either in combination with antibiotics or as a single agent. These products are available over-the-counter or by prescription in gels, creams or liquids at concentrations of 2.5%, 5% or 10%. Benzoyl peroxide is also used for bleaching flour or hair, teeth whitening, for cross-linking polyester resins, and many other chemical uses. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.
DB00446ChloramphenicolAn antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)
DB04815ClioquinolClioquinol was withdrawn in 1983 due to neurotoxicity.
DB03085Glycolic acidNot Available
DB14104Linoleic acidNot Available
DB00936Salicylic acidA compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics.
DB12965SilverSilver (Ag) is a chemical element that belongs in the family of transition metals in the periodic table. It has a high electrical conductivity, thermal conductivity, and reflectivity. Silver exists as a pure elemental form, alloy with other metals, and mineral. Having critical roles in various applications inducing chemical and industrial fields, silver compounds have also been used in the field of medicine for centuries due to their broad-spectrum biological actions. Silver nanoparticles especially have been widely used in industrial, household, and healthcare-related products due to their potent antimicrobial activity. [DB11080] and [DB05245] have been used as topical antibacterial agents for the treatment of skin infections, while [DB05245] has also been valued for topical burn treatment [A33141]. Silver and its compounds have been used in trials studying the management of dental caries since the 1800s, and they may be found in dental pastes as an active ingredients. However, some drawbacks of dental use of silver compounds include tooth discolouration and pulp irritation [A33141].
DB00421SpironolactoneA potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
DB09353SulfurSulfur is a chemical element that is present in all living tissues. After calcium and phosphorus, it is the third most abundant mineral in the human body. Sulfur is also found in garlic, onions and broccoli. People take sulfur by mouth for shortness of breath, allergies, swelling in the back of the throat (pharyngitis), high cholesterol, clogged arteries, menopause, and upper respiratory tract infections like the common cold. Sulfur seems to have an antibacterial activity. It has been also used for acne.
DB05294VandetanibVandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients.
DrugDrug NameTargetType
DB00446ChloramphenicolCytochrome P450 2C19enzyme
DB00446ChloramphenicolCytochrome P450 3A4enzyme
DB00446ChloramphenicolCytochrome P450 3A5enzyme
DB00446ChloramphenicolCytochrome P450 3A7enzyme
DB00446ChloramphenicolChloramphenicol acetyltransferase 3enzyme
DB00446ChloramphenicolChloramphenicol acetyltransferaseenzyme
DB00446ChloramphenicolChloramphenicol 3-O phosphotransferaseenzyme
DB00446ChloramphenicolCytochrome P450 2C8enzyme
DB00446ChloramphenicolCytochrome P450 2C9enzyme
DB00446Chloramphenicol50S ribosomal protein L16target
DB00446ChloramphenicolDr hemagglutinin structural subunittarget
DB00446ChloramphenicolComplement decay-accelerating factortarget
DB00446ChloramphenicolSolute carrier family 22 member 6transporter
DB03085Glycolic acidGlucose-6-phosphate 1-dehydrogenasetarget
DB03085Glycolic acidGlycine oxidasetarget
DB00936Salicylic acidSerum albumincarrier
DB00936Salicylic acidProstaglandin G/H synthase 1target
DB00936Salicylic acidProstaglandin G/H synthase 2target
DB00936Salicylic acidAldo-keto reductase family 1 member C1target
DB00936Salicylic acidSolute carrier family 22 member 6transporter
DB00936Salicylic acidSolute carrier family 22 member 10transporter
DB00936Salicylic acidSolute carrier family 22 member 8transporter
DB00936Salicylic acidSolute carrier family 22 member 11transporter
DB00936Salicylic acidSolute carrier organic anion transporter family member 2B1transporter
DB00936Salicylic acidMonocarboxylate transporter 1transporter
DB00936Salicylic acidSolute carrier family 22 member 7transporter
DB00936Salicylic acidCytochrome P450 2C9enzyme
DB12965SilverMetallothioneintarget
DB12965SilverCeruloplasmintarget
DB12965SilverSerum albumintarget
DB12965SilverAlpha-2-macroglobulintarget
DB00421SpironolactoneMineralocorticoid receptortarget
DB00421SpironolactoneCytochrome P450 2C8enzyme
DB00421SpironolactoneCanalicular multispecific organic anion transporter 1transporter
DB00421SpironolactoneMultidrug resistance protein 1transporter
DB00421SpironolactoneSolute carrier organic anion transporter family member 1A2transporter
DB00421SpironolactoneCytochrome P450 11B1, mitochondrialenzyme
DB00421SpironolactoneAndrogen receptortarget
DB00421SpironolactoneProgesterone receptortarget
DB00421SpironolactoneGlucocorticoid receptortarget
DB00421SpironolactoneCytochrome P450 11B2, mitochondrialtarget
DB00421Spironolactone17alpha-hydroxylasetarget
DB00421Spironolactone17,20-desmolasetarget
DB00421Spironolactone3-oxo-5-alpha-steroid 4-dehydrogenasetarget
DB00421SpironolactoneSex hormone-binding globulintarget
DB00421SpironolactoneVoltage-dependent calcium channeltarget
DB00421SpironolactoneDihydrotestosterone receptortarget
DB00421SpironolactoneNuclear receptor subfamily 1 group I member 2target
DB00421SpironolactoneBile salt export pumptransporter
DB05294VandetanibVascular endothelial growth factor Atarget
DB05294VandetanibEpidermal growth factor receptortarget
DB05294VandetanibMultidrug resistance-associated protein 1transporter
DB05294VandetanibATP-binding cassette sub-family G member 2transporter
DB05294VandetanibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB05294VandetanibDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB05294VandetanibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB05294VandetanibProtein-tyrosine kinase 6target
DB05294VandetanibAngiopoietin-1 receptortarget
DB05294VandetanibAlpha-1-acid glycoprotein 1carrier
DB05294VandetanibSerum albumincarrier
DB05294VandetanibCytochrome P450 3A4enzyme
DrugDrug NamePhaseStatusCount
DB00982Isotretinoin1Completed1
DB00799Tazarotene1Completed1
DB04980Lemuteporfin1 / 2Completed1
DB05676Apremilast2Terminated1
DB00207Azithromycin2Unknown Status1
DB06133Dimethylcurcumin2Completed1
DB00254Doxycycline2Unknown Status1
DB05681Talarozole2Completed1
DB13083Talarozole2Completed1
DB00254Doxycycline2 / 3Unknown Status1
DB00848Levamisole2 / 3Completed1
DB00210Adapalene3Completed3
DB09096Benzoyl peroxide3Completed4
DB01190Clindamycin3Completed3
DB00250Dapsone3Completed1
DB00254Doxycycline3Completed1
DB00982Isotretinoin3Completed1
DB00755Tretinoin3Completed4
DB00210Adapalene4Completed2
DB09096Benzoyl peroxide4Completed1
DB01190Clindamycin4Completed1
DB01190Clindamycin4Unknown Status1
DB00250Dapsone4Recruiting2
DB00254Doxycycline4Completed1
DB00254Doxycycline4Recruiting1
DB00982Isotretinoin4Active Not Recruiting1
DB01017Minocycline4Completed1
DB00936Salicylic acid4Completed2
DB00755Tretinoin4Completed1
DB00210AdapaleneNot AvailableCompleted1
DB00548Azelaic AcidNot AvailableUnknown Status1
DB09096Benzoyl peroxideNot AvailableCompleted1
DB01395DrospirenoneNot AvailableCompleted1
DB00977Ethinyl EstradiolNot AvailableCompleted1
DB00982IsotretinoinNot AvailableCompleted1
DB12622LupeolNot AvailableCompleted2
DB00755TretinoinNot AvailableActive Not Recruiting1
DB00620TriamcinoloneNot AvailableActive Not Recruiting1