Protocatechualdehyde

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Protocatechualdehyde
Accession Number
DB11268
Type
Small Molecule
Groups
Approved
Description

Also known as protocatechuic aldehyde, protocatechualdehyde is a naturally-occuring phenolic aldehyde that is found in barley, green cavendish bananas, grapevine leaves and root of the herb S. miltiorrhiza [1]. Protocatechualdehyde possesses antiproliferative and pro-apoptotic properties against human breast cancer cells and colorectal cancer cells by reducing the expression of pro-oncogenes β-catenin and cyclin D1.

Structure
Thumb
Synonyms
  • 3,4-dihydroxybenzaldehyde
  • 3,4-Dihydroxybenzaldehyde
  • protocatechuic aldehyde
  • Rancinamycin IV
External IDs
NSC-22961
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
O Hui White Extreme CellightProtocatechualdehyde (.0315 mL/100mL)EmulsionTopicalLg Household & Health Care Ltd.2011-03-07Not applicableUs
O Hui White Extreme CellightProtocatechualdehyde (.032 mL/100mL)CreamTopicalLg Household & Health Care Ltd.2011-03-16Not applicableUs
Categories
UNII
4PVP2HCH4T
CAS number
Not Available
Weight
Average: 138.1207
Monoisotopic: 138.031694058
Chemical Formula
C7H6O3
InChI Key
IBGBGRVKPALMCQ-UHFFFAOYSA-N
InChI
InChI=1S/C7H6O3/c8-4-5-1-2-6(9)7(10)3-5/h1-4,9-10H
IUPAC Name
3,4-dihydroxybenzaldehyde
SMILES
OC1=CC=C(C=O)C=C1O

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(4R)-limonene(4R)-limonene may increase the anticoagulant activities of Protocatechualdehyde.Investigational
AbciximabAbciximab may increase the anticoagulant activities of Protocatechualdehyde.Approved
AceclofenacAceclofenac may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
AcemetacinThe risk or severity of bleeding can be increased when Protocatechualdehyde is combined with Acemetacin.Approved, Experimental, Investigational
AcenocoumarolAcenocoumarol may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
Acetylsalicylic acidAcetylsalicylic acid may increase the anticoagulant activities of Protocatechualdehyde.Approved, Vet Approved
AdapaleneAdapalene may increase the anticoagulant activities of Protocatechualdehyde.Approved
AlclofenacAlclofenac may increase the anticoagulant activities of Protocatechualdehyde.Approved, Withdrawn
AllylestrenolThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Allylestrenol.Approved
AlminoprofenAlminoprofen may increase the anticoagulant activities of Protocatechualdehyde.Experimental
AloxiprinAloxiprin may increase the anticoagulant activities of Protocatechualdehyde.Experimental
AlprostadilAlprostadil may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
AlteplaseAlteplase may increase the anticoagulant activities of Protocatechualdehyde.Approved
AltrenogestThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Altrenogest.Vet Approved
Aminosalicylic AcidAminosalicylic Acid may increase the anticoagulant activities of Protocatechualdehyde.Approved
AnagrelideAnagrelide may increase the anticoagulant activities of Protocatechualdehyde.Approved
AncrodAncrod may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
AndrographolideAndrographolide may increase the anticoagulant activities of Protocatechualdehyde.Investigational
AnisodamineAnisodamine may increase the anticoagulant activities of Protocatechualdehyde.Investigational
AnistreplaseAnistreplase may increase the anticoagulant activities of Protocatechualdehyde.Approved
AntipyrineAntipyrine may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
Antithrombin III humanProtocatechualdehyde may increase the anticoagulant activities of Antithrombin III human.Approved
ApixabanApixaban may increase the anticoagulant activities of Protocatechualdehyde.Approved
ApocyninApocynin may increase the anticoagulant activities of Protocatechualdehyde.Investigational
ApremilastApremilast may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
ArdeparinArdeparin may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational, Withdrawn
ArgatrobanArgatroban may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
AstaxanthinAstaxanthin may increase the anticoagulant activities of Protocatechualdehyde.Investigational
AzapropazoneAzapropazone may increase the anticoagulant activities of Protocatechualdehyde.Withdrawn
AzelastineAzelastine may increase the anticoagulant activities of Protocatechualdehyde.Approved
Azficel-TThe risk or severity of adverse effects can be increased when Protocatechualdehyde is combined with Azficel-T.Approved, Investigational
BalsalazideBalsalazide may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
BatroxobinBatroxobin may increase the anticoagulant activities of Protocatechualdehyde.Experimental
BazedoxifeneBazedoxifene may decrease the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
BecaplerminBecaplermin may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
BemiparinBemiparin may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
BendazacBendazac may increase the anticoagulant activities of Protocatechualdehyde.Experimental
BenorilateBenorilate may increase the anticoagulant activities of Protocatechualdehyde.Experimental
BenoxaprofenBenoxaprofen may increase the anticoagulant activities of Protocatechualdehyde.Withdrawn
BenzydamineBenzydamine may increase the anticoagulant activities of Protocatechualdehyde.Approved
BeraprostBeraprost may increase the anticoagulant activities of Protocatechualdehyde.Investigational
BevoniumBevonium may increase the anticoagulant activities of Protocatechualdehyde.Experimental
BivalirudinBivalirudin may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
BrinaseBrinase may increase the anticoagulant activities of Protocatechualdehyde.Experimental
BromfenacBromfenac may increase the anticoagulant activities of Protocatechualdehyde.Approved
BucillamineBucillamine may increase the anticoagulant activities of Protocatechualdehyde.Investigational
BufexamacBufexamac may increase the anticoagulant activities of Protocatechualdehyde.Approved, Experimental
BuflomedilBuflomedil may increase the anticoagulant activities of Protocatechualdehyde.Experimental
BumadizoneBumadizone may increase the anticoagulant activities of Protocatechualdehyde.Experimental
ButylphthalideButylphthalide may increase the anticoagulant activities of Protocatechualdehyde.Investigational
Calcium carbimideThe risk or severity of adverse effects can be increased when Calcium carbimide is combined with Protocatechualdehyde.Approved, Withdrawn
CangrelorCangrelor may increase the anticoagulant activities of Protocatechualdehyde.Approved
CaplacizumabCaplacizumab may increase the anticoagulant activities of Protocatechualdehyde.Investigational
Carbaspirin calciumCarbaspirin calcium may increase the anticoagulant activities of Protocatechualdehyde.Experimental, Investigational
CarprofenCarprofen may increase the anticoagulant activities of Protocatechualdehyde.Approved, Vet Approved, Withdrawn
CastanospermineCastanospermine may increase the anticoagulant activities of Protocatechualdehyde.Experimental
CelecoxibCelecoxib may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
CertoparinCertoparin may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
ChlormadinoneThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Chlormadinone.Experimental
ChloroquineChloroquine may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational, Vet Approved
ChlorotrianiseneChlorotrianisene may decrease the anticoagulant activities of Protocatechualdehyde.Investigational, Withdrawn
Choline magnesium trisalicylateCholine magnesium trisalicylate may increase the anticoagulant activities of Protocatechualdehyde.Approved
CilostazolCilostazol may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
Citric AcidCitric Acid may increase the anticoagulant activities of Protocatechualdehyde.Approved, Nutraceutical, Vet Approved
ClonixinClonixin may increase the anticoagulant activities of Protocatechualdehyde.Approved
ClopidogrelClopidogrel may increase the anticoagulant activities of Protocatechualdehyde.Approved
CloricromenCloricromen may increase the anticoagulant activities of Protocatechualdehyde.Experimental
ClorindioneClorindione may increase the anticoagulant activities of Protocatechualdehyde.Experimental
Collagenase clostridium histolyticumThe risk or severity of adverse effects can be increased when Protocatechualdehyde is combined with Collagenase clostridium histolyticum.Approved, Investigational
Conjugated estrogensConjugated estrogens may decrease the anticoagulant activities of Protocatechualdehyde.Approved
CurcuminCurcumin may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
Dabigatran etexilateDabigatran etexilate may increase the anticoagulant activities of Protocatechualdehyde.Approved
DaidzeinDaidzein may decrease the anticoagulant activities of Protocatechualdehyde.Experimental
DalteparinDalteparin may increase the anticoagulant activities of Protocatechualdehyde.Approved
DanaparoidDanaparoid may increase the anticoagulant activities of Protocatechualdehyde.Approved, Withdrawn
DarexabanProtocatechualdehyde may increase the anticoagulant activities of Darexaban.Investigational
DasatinibDasatinib may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
DeferasiroxThe risk or severity of adverse effects can be increased when Protocatechualdehyde is combined with Deferasirox.Approved, Investigational
DefibrotideDefibrotide may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
DemegestoneThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Demegestone.Approved
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Protocatechualdehyde is combined with Deoxycholic Acid.Approved
DersalazineDersalazine may increase the anticoagulant activities of Protocatechualdehyde.Investigational
DesirudinDesirudin may increase the anticoagulant activities of Protocatechualdehyde.Approved
DesmoteplaseDesmoteplase may increase the anticoagulant activities of Protocatechualdehyde.Investigational
DesogestrelThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Desogestrel.Approved
DesvenlafaxineDesvenlafaxine may increase the antiplatelet activities of Protocatechualdehyde.Approved, Investigational
DextranDextran may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational, Vet Approved
DiclofenacDiclofenac may increase the anticoagulant activities of Protocatechualdehyde.Approved, Vet Approved
DicoumarolDicoumarol may increase the anticoagulant activities of Protocatechualdehyde.Approved
DienestrolDienestrol may decrease the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
DienogestThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Dienogest.Approved
DiethylstilbestrolDiethylstilbestrol may decrease the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
DifenpiramideDifenpiramide may increase the anticoagulant activities of Protocatechualdehyde.Experimental
DiflunisalDiflunisal may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
DiphenadioneDiphenadione may increase the anticoagulant activities of Protocatechualdehyde.Experimental
DipyridamoleDipyridamole may increase the anticoagulant activities of Protocatechualdehyde.Approved
DitazoleDitazole may increase the anticoagulant activities of Protocatechualdehyde.Approved, Withdrawn
DrospirenoneThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Drospirenone.Approved
Drotrecogin alfaDrotrecogin alfa may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational, Withdrawn
DroxicamDroxicam may increase the anticoagulant activities of Protocatechualdehyde.Withdrawn
DuvelisibDuvelisib may increase the anticoagulant activities of Protocatechualdehyde.Investigational
DydrogesteroneThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Dydrogesterone.Approved, Investigational, Withdrawn
E-6201E-6201 may increase the anticoagulant activities of Protocatechualdehyde.Investigational
Edetic AcidEdetic Acid may increase the anticoagulant activities of Protocatechualdehyde.Approved, Vet Approved
EdoxabanEdoxaban may increase the anticoagulant activities of Protocatechualdehyde.Approved
EnoxaparinEnoxaparin may increase the anticoagulant activities of Protocatechualdehyde.Approved
EpimestrolEpimestrol may decrease the anticoagulant activities of Protocatechualdehyde.Experimental
EpinastineEpinastine may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
EpirizoleEpirizole may increase the anticoagulant activities of Protocatechualdehyde.Approved
EplivanserinEplivanserin may increase the anticoagulant activities of Protocatechualdehyde.Investigational
EpoprostenolEpoprostenol may increase the anticoagulant activities of Protocatechualdehyde.Approved
EptifibatideEptifibatide may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
EquolEquol may decrease the anticoagulant activities of Protocatechualdehyde.Investigational
EstradiolEstradiol may decrease the anticoagulant activities of Protocatechualdehyde.Approved, Investigational, Vet Approved
Estradiol acetateEstradiol acetate may decrease the anticoagulant activities of Protocatechualdehyde.Approved, Investigational, Vet Approved
Estradiol cypionateEstradiol cypionate may decrease the anticoagulant activities of Protocatechualdehyde.Approved, Investigational, Vet Approved
Estradiol valerateEstradiol valerate may decrease the anticoagulant activities of Protocatechualdehyde.Approved, Investigational, Vet Approved
EstriolEstriol may decrease the anticoagulant activities of Protocatechualdehyde.Approved, Investigational, Vet Approved
Estrogens, esterifiedEstrogens, esterified may decrease the anticoagulant activities of Protocatechualdehyde.Approved
EstroneEstrone may decrease the anticoagulant activities of Protocatechualdehyde.Approved
EtanerceptEtanercept may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
EthenzamideEthenzamide may increase the anticoagulant activities of Protocatechualdehyde.Experimental
Ethinyl EstradiolEthinyl Estradiol may decrease the anticoagulant activities of Protocatechualdehyde.Approved
Ethyl biscoumacetateEthyl biscoumacetate may increase the anticoagulant activities of Protocatechualdehyde.Withdrawn
EthynodiolThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Ethynodiol.Experimental
EtodolacEtodolac may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
EtonogestrelThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Etonogestrel.Approved, Investigational
EtoricoxibEtoricoxib may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
Evening primrose oilEvening primrose oil may increase the anticoagulant activities of Protocatechualdehyde.Investigational, Nutraceutical
ExisulindExisulind may increase the anticoagulant activities of Protocatechualdehyde.Investigational
FelbinacFelbinac may increase the anticoagulant activities of Protocatechualdehyde.Experimental
FenbufenFenbufen may increase the anticoagulant activities of Protocatechualdehyde.Approved
FenoprofenFenoprofen may increase the anticoagulant activities of Protocatechualdehyde.Approved
FentiazacFentiazac may increase the anticoagulant activities of Protocatechualdehyde.Experimental
FeprazoneFeprazone may increase the anticoagulant activities of Protocatechualdehyde.Experimental
Ferulic acidFerulic acid may increase the anticoagulant activities of Protocatechualdehyde.Experimental
FibrinolysinFibrinolysin may increase the anticoagulant activities of Protocatechualdehyde.Investigational
FloctafenineFloctafenine may increase the anticoagulant activities of Protocatechualdehyde.Approved, Withdrawn
FluindioneProtocatechualdehyde may increase the anticoagulant activities of Fluindione.Approved, Investigational
FlunixinFlunixin may increase the anticoagulant activities of Protocatechualdehyde.Vet Approved
FlunoxaprofenFlunoxaprofen may increase the anticoagulant activities of Protocatechualdehyde.Experimental
FluoxetineFluoxetine may increase the antiplatelet activities of Protocatechualdehyde.Approved, Vet Approved
FlurbiprofenFlurbiprofen may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
FondaparinuxFondaparinux sodium may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
GabexateProtocatechualdehyde may increase the anticoagulant activities of Gabexate.Investigational
GenisteinGenistein may decrease the anticoagulant activities of Protocatechualdehyde.Investigational
GestodeneThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Gestodene.Approved, Investigational
GestonoroneThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Gestonorone.Experimental
GestrinoneThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Gestrinone.Approved
GuacetisalGuacetisal may increase the anticoagulant activities of Protocatechualdehyde.Experimental
HeminHemin may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
Hemoglobin crosfumarilHemoglobin crosfumaril may increase the anticoagulant activities of Protocatechualdehyde.Experimental
HeparinHeparin may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
HexestrolHexestrol may decrease the anticoagulant activities of Protocatechualdehyde.Withdrawn
HigenamineHigenamine may increase the anticoagulant activities of Protocatechualdehyde.Investigational
Hydroxyprogesterone caproateThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Hydroxyprogesterone caproate.Approved, Investigational
HydroxytyrosolHydroxytyrosol may increase the anticoagulant activities of Protocatechualdehyde.Investigational
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Protocatechualdehyde is combined with Ibritumomab tiuxetan.Approved, Investigational
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Protocatechualdehyde.Approved
IbudilastIbudilast may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
IbuprofenThe risk or severity of bleeding and hemorrhage can be increased when Ibuprofen is combined with Protocatechualdehyde.Approved
IbuproxamIbuproxam may increase the anticoagulant activities of Protocatechualdehyde.Withdrawn
IcatibantIcatibant may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
Icosapent ethylIcosapent ethyl may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational, Nutraceutical
IdraparinuxIdraparinux may increase the anticoagulant activities of Protocatechualdehyde.Investigational
IfenprodilIfenprodil may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational, Withdrawn
IfetrobanIfetroban may increase the anticoagulant activities of Protocatechualdehyde.Investigational
IloprostIloprost may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
Imidazole salicylateImidazole salicylate may increase the anticoagulant activities of Protocatechualdehyde.Experimental
IndobufenIndobufen may increase the anticoagulant activities of Protocatechualdehyde.Investigational
IndomethacinIndomethacin may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
IndoprofenIndoprofen may increase the anticoagulant activities of Protocatechualdehyde.Withdrawn
IsoxicamIsoxicam may increase the anticoagulant activities of Protocatechualdehyde.Withdrawn
KebuzoneKebuzone may increase the anticoagulant activities of Protocatechualdehyde.Experimental
KetanserinKetanserin may increase the anticoagulant activities of Protocatechualdehyde.Investigational
KetoprofenKetoprofen may increase the anticoagulant activities of Protocatechualdehyde.Approved, Vet Approved
KetorolacKetorolac may increase the anticoagulant activities of Protocatechualdehyde.Approved
LeflunomideLeflunomide may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
LepirudinProtocatechualdehyde may increase the anticoagulant activities of Lepirudin.Approved
LetaxabanProtocatechualdehyde may increase the anticoagulant activities of Letaxaban.Investigational
LevonorgestrelThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Levonorgestrel.Approved, Investigational
LimaprostThe risk or severity of adverse effects can be increased when Limaprost is combined with Protocatechualdehyde.Approved, Investigational
LinsidomineLinsidomine may increase the anticoagulant activities of Protocatechualdehyde.Experimental
LisofyllineLisofylline may increase the anticoagulant activities of Protocatechualdehyde.Investigational
LonazolacLonazolac may increase the anticoagulant activities of Protocatechualdehyde.Experimental
LornoxicamLornoxicam may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
LoxoprofenLoxoprofen may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
LumiracoxibLumiracoxib may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
LynestrenolThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Lynestrenol.Approved, Investigational
Magnesium salicylateMagnesium salicylate may increase the anticoagulant activities of Protocatechualdehyde.Approved
MasoprocolMasoprocol may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
Meclofenamic acidMeclofenamic acid may increase the anticoagulant activities of Protocatechualdehyde.Approved, Vet Approved
MedrogestoneThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Medrogestone.Approved
Medroxyprogesterone acetateThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Medroxyprogesterone acetate.Approved, Investigational
Mefenamic acidMefenamic acid may increase the anticoagulant activities of Protocatechualdehyde.Approved
Megestrol acetateThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Megestrol acetate.Approved, Investigational, Vet Approved
MelagatranProtocatechualdehyde may increase the anticoagulant activities of Melagatran.Experimental
MeloxicamMeloxicam may increase the anticoagulant activities of Protocatechualdehyde.Approved, Vet Approved
MesalazineMesalazine may increase the anticoagulant activities of Protocatechualdehyde.Approved
MestranolMestranol may decrease the anticoagulant activities of Protocatechualdehyde.Approved
MetamizoleMetamizole may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational, Withdrawn
MethallenestrilMethallenestril may decrease the anticoagulant activities of Protocatechualdehyde.Experimental
Methyl salicylateMethyl salicylate may increase the anticoagulant activities of Protocatechualdehyde.Approved, Vet Approved
MethylestrenoloneThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Methylestrenolone.Experimental
MilrinoneMilrinone may increase the anticoagulant activities of Protocatechualdehyde.Approved
MizoribineMizoribine may increase the anticoagulant activities of Protocatechualdehyde.Investigational
MofebutazoneMofebutazone may increase the anticoagulant activities of Protocatechualdehyde.Experimental
MoxestrolMoxestrol may decrease the anticoagulant activities of Protocatechualdehyde.Experimental
Mycophenolate mofetilMycophenolate mofetil may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
Mycophenolic acidMycophenolic acid may increase the anticoagulant activities of Protocatechualdehyde.Approved
NabumetoneNabumetone may increase the anticoagulant activities of Protocatechualdehyde.Approved
NadroparinNadroparin may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
NafamostatNafamostat may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
NaftifineNaftifine may increase the anticoagulant activities of Protocatechualdehyde.Approved
NaftopidilNaftopidil may increase the anticoagulant activities of Protocatechualdehyde.Investigational
NaproxenNaproxen may increase the anticoagulant activities of Protocatechualdehyde.Approved, Vet Approved
NepafenacNepafenac may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
NifenazoneNifenazone may increase the anticoagulant activities of Protocatechualdehyde.Experimental
Niflumic AcidNiflumic Acid may increase the anticoagulant activities of Protocatechualdehyde.Approved
NimesulideNimesulide may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational, Withdrawn
NintedanibThe risk or severity of adverse effects can be increased when Protocatechualdehyde is combined with Nintedanib.Approved
NitroaspirinNitroaspirin may increase the anticoagulant activities of Protocatechualdehyde.Investigational
NomegestrolThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Nomegestrol.Approved
NorethisteroneThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Norethisterone.Approved
NorgestrienoneThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Norgestrienone.Experimental
ObinutuzumabThe risk or severity of adverse effects can be increased when Protocatechualdehyde is combined with Obinutuzumab.Approved, Investigational
OlopatadineOlopatadine may increase the anticoagulant activities of Protocatechualdehyde.Approved
OlsalazineOlsalazine may increase the anticoagulant activities of Protocatechualdehyde.Approved
Omacetaxine mepesuccinateThe risk or severity of bleeding can be increased when Protocatechualdehyde is combined with Omacetaxine mepesuccinate.Approved, Investigational
Omega-3 fatty acidsOmega-3 fatty acids may increase the anticoagulant activities of Protocatechualdehyde.Approved, Nutraceutical
Omega-3-carboxylic acidsThe therapeutic efficacy of Protocatechualdehyde can be increased when used in combination with Omega-3-carboxylic acids.Approved, Investigational
OrgoteinOrgotein may increase the anticoagulant activities of Protocatechualdehyde.Vet Approved
OtamixabanOtamixaban may increase the anticoagulant activities of Protocatechualdehyde.Investigational
OxaprozinOxaprozin may increase the anticoagulant activities of Protocatechualdehyde.Approved
OxyphenbutazoneOxyphenbutazone may increase the anticoagulant activities of Protocatechualdehyde.Approved, Withdrawn
OzagrelOzagrel may increase the anticoagulant activities of Protocatechualdehyde.Investigational
PalmidrolPalmidrol may increase the anticoagulant activities of Protocatechualdehyde.Experimental, Nutraceutical
ParecoxibParecoxib may increase the anticoagulant activities of Protocatechualdehyde.Approved
ParnaparinParnaparin may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
ParthenolideParthenolide may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
Pentaerythritol TetranitratePentaerythritol Tetranitrate may increase the anticoagulant activities of Protocatechualdehyde.Approved
Pentosan PolysulfatePentosan Polysulfate may increase the anticoagulant activities of Protocatechualdehyde.Approved
PentoxifyllinePentoxifylline may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
PhenindionePhenindione may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
PhenprocoumonPhenprocoumon may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
Phenyl aminosalicylatePhenyl aminosalicylate may increase the anticoagulant activities of Protocatechualdehyde.Approved
PhenylbutazonePhenylbutazone may increase the anticoagulant activities of Protocatechualdehyde.Approved, Vet Approved
PicotamidePicotamide may increase the anticoagulant activities of Protocatechualdehyde.Experimental
PimecrolimusPimecrolimus may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
PirfenidonePirfenidone may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
PiroxicamPiroxicam may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
PirprofenPirprofen may increase the anticoagulant activities of Protocatechualdehyde.Experimental
Polyestradiol phosphatePolyestradiol phosphate may decrease the anticoagulant activities of Protocatechualdehyde.Approved
Potassium CitrateProtocatechualdehyde may increase the anticoagulant activities of Potassium Citrate.Approved, Investigational, Vet Approved
PranoprofenPranoprofen may increase the anticoagulant activities of Protocatechualdehyde.Experimental, Investigational
PrasugrelPrasugrel may increase the anticoagulant activities of Protocatechualdehyde.Approved
ProgesteroneThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Progesterone.Approved, Vet Approved
ProglumetacinProglumetacin may increase the anticoagulant activities of Protocatechualdehyde.Experimental
PromegestoneThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Promegestone.Experimental
PromestrienePromestriene may decrease the anticoagulant activities of Protocatechualdehyde.Investigational
PropacetamolPropacetamol may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
PropyphenazonePropyphenazone may increase the anticoagulant activities of Protocatechualdehyde.Experimental
ProquazoneProquazone may increase the anticoagulant activities of Protocatechualdehyde.Experimental
Protein CProtocatechualdehyde may increase the anticoagulant activities of Protein C.Approved
Protein S humanProtocatechualdehyde may increase the anticoagulant activities of Protein S human.Approved
PTC299PTC299 may increase the anticoagulant activities of Protocatechualdehyde.Investigational
QuinestrolQuinestrol may decrease the anticoagulant activities of Protocatechualdehyde.Approved
QuingestanolThe therapeutic efficacy of Protocatechualdehyde can be decreased when used in combination with Quingestanol.Experimental
RamatrobanRamatroban may increase the anticoagulant activities of Protocatechualdehyde.Investigational
RelcovaptanRelcovaptan may increase the anticoagulant activities of Protocatechualdehyde.Investigational
ResveratrolResveratrol may increase the anticoagulant activities of Protocatechualdehyde.Approved, Experimental, Investigational
ReteplaseReteplase may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
ReviparinReviparin may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
RidogrelRidogrel may increase the anticoagulant activities of Protocatechualdehyde.Approved
RivaroxabanProtocatechualdehyde may increase the anticoagulant activities of Rivaroxaban.Approved
RofecoxibRofecoxib may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational, Withdrawn
SalicylamideSalicylamide may increase the anticoagulant activities of Protocatechualdehyde.Approved
Salicylic acidThe risk or severity of bleeding can be increased when Salicylic acid is combined with Protocatechualdehyde.Approved, Investigational, Vet Approved
SalsalateSalsalate may increase the anticoagulant activities of Protocatechualdehyde.Approved
SarpogrelateSarpogrelate may increase the anticoagulant activities of Protocatechualdehyde.Investigational
SecoisolariciresinolSecoisolariciresinol may decrease the anticoagulant activities of Protocatechualdehyde.Investigational
SelexipagSelexipag may increase the anticoagulant activities of Protocatechualdehyde.Approved
SemapimodSemapimod may increase the anticoagulant activities of Protocatechualdehyde.Investigational
SeratrodastSeratrodast may increase the anticoagulant activities of Protocatechualdehyde.Approved
SerrapeptaseSerrapeptase may increase the anticoagulant activities of Protocatechualdehyde.Investigational
SevofluraneSevoflurane may increase the anticoagulant activities of Protocatechualdehyde.Approved, Vet Approved
Sodium CitrateProtocatechualdehyde may increase the anticoagulant activities of Sodium Citrate.Approved, Investigational
SRT501SRT501 may increase the anticoagulant activities of Protocatechualdehyde.Investigational
StreptokinaseStreptokinase may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
SugammadexSugammadex may increase the anticoagulant activities of Protocatechualdehyde.Approved
SulfasalazineSulfasalazine may increase the anticoagulant activities of Protocatechualdehyde.Approved
SulindacSulindac may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
SulodexideSulodexide may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
SuprofenSuprofen may increase the anticoagulant activities of Protocatechualdehyde.Approved, Withdrawn
SuxibuzoneSuxibuzone may increase the anticoagulant activities of Protocatechualdehyde.Experimental
Synthetic Conjugated Estrogens, ASynthetic Conjugated Estrogens, A may decrease the anticoagulant activities of Protocatechualdehyde.Approved
Synthetic Conjugated Estrogens, BSynthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Protocatechualdehyde.Approved
TarenflurbilTarenflurbil may increase the anticoagulant activities of Protocatechualdehyde.Investigational
TenecteplaseTenecteplase may increase the anticoagulant activities of Protocatechualdehyde.Approved
TenidapTenidap may increase the anticoagulant activities of Protocatechualdehyde.Experimental
TenoxicamTenoxicam may increase the anticoagulant activities of Protocatechualdehyde.Approved
TepoxalinTepoxalin may increase the anticoagulant activities of Protocatechualdehyde.Vet Approved
TeriflunomideTeriflunomide may increase the anticoagulant activities of Protocatechualdehyde.Approved
TesmilifeneTesmilifene may increase the anticoagulant activities of Protocatechualdehyde.Investigational
Testosterone cypionateThe therapeutic efficacy of Protocatechualdehyde can be increased when used in combination with Testosterone cypionate.Approved
Testosterone enanthateThe therapeutic efficacy of Protocatechualdehyde can be increased when used in combination with Testosterone enanthate.Approved
Testosterone undecanoateThe therapeutic efficacy of Protocatechualdehyde can be increased when used in combination with Testosterone undecanoate.Approved, Investigational
Tiaprofenic acidTiaprofenic acid may increase the anticoagulant activities of Protocatechualdehyde.Approved
TiboloneTibolone may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
TicagrelorTicagrelor may increase the anticoagulant activities of Protocatechualdehyde.Approved
TiclopidineTiclopidine may increase the anticoagulant activities of Protocatechualdehyde.Approved
TinoridineTinoridine may increase the anticoagulant activities of Protocatechualdehyde.Investigational
TinzaparinTinzaparin may increase the anticoagulant activities of Protocatechualdehyde.Approved
TioclomarolTioclomarol may increase the anticoagulant activities of Protocatechualdehyde.Experimental
TipranavirTipranavir may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
TirofibanTirofiban may increase the anticoagulant activities of Protocatechualdehyde.Approved
Tolfenamic AcidTolfenamic Acid may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
TolmetinTolmetin may increase the anticoagulant activities of Protocatechualdehyde.Approved
TositumomabThe risk or severity of adverse effects can be increased when Protocatechualdehyde is combined with Tositumomab.Approved, Investigational
TranilastTranilast may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
TrapidilTrapidil may increase the anticoagulant activities of Protocatechualdehyde.Approved
TreprostinilTreprostinil may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
TribenosideTribenoside may increase the anticoagulant activities of Protocatechualdehyde.Experimental
TriflusalTriflusal may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
TriptolideTriptolide may increase the anticoagulant activities of Protocatechualdehyde.Investigational
Trolamine salicylateTrolamine salicylate may increase the anticoagulant activities of Protocatechualdehyde.Approved
TroxerutinProtocatechualdehyde may increase the anticoagulant activities of Troxerutin.Investigational
UrokinaseUrokinase may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational, Withdrawn
ValdecoxibValdecoxib may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational, Withdrawn
VenlafaxineVenlafaxine may increase the antiplatelet activities of Protocatechualdehyde.Approved
Vitamin EVitamin E may increase the anticoagulant activities of Protocatechualdehyde.Approved, Nutraceutical, Vet Approved
VorapaxarThe risk or severity of adverse effects can be increased when Vorapaxar is combined with Protocatechualdehyde.Approved
WarfarinWarfarin may increase the anticoagulant activities of Protocatechualdehyde.Approved
XimelagatranXimelagatran may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational, Withdrawn
ZaltoprofenZaltoprofen may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational
ZeranolZeranol may decrease the anticoagulant activities of Protocatechualdehyde.Vet Approved
ZileutonZileuton may increase the anticoagulant activities of Protocatechualdehyde.Approved, Investigational, Withdrawn
ZomepiracZomepirac may increase the anticoagulant activities of Protocatechualdehyde.Withdrawn
Food Interactions
Not Available

References

General References
  1. Jeong JB, Lee SH: Protocatechualdehyde possesses anti-cancer activity through downregulating cyclin D1 and HDAC2 in human colorectal cancer cells. Biochem Biophys Res Commun. 2013 Jan 4;430(1):381-6. doi: 10.1016/j.bbrc.2012.11.018. Epub 2012 Nov 14. [PubMed:23159608]
  2. Choi J, Jiang X, Jeong JB, Lee SH: Anticancer activity of protocatechualdehyde in human breast cancer cells. J Med Food. 2014 Aug;17(8):842-8. doi: 10.1089/jmf.2013.0159. Epub 2014 Apr 8. [PubMed:24712725]
External Links
Human Metabolome Database
HMDB0059965
KEGG Compound
C16700
PubChem Compound
8768
PubChem Substance
347827959
ChemSpider
8438
ChEBI
50205
ChEMBL
CHEMBL222021
Wikipedia
Protocatechuic_aldehyde

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
CreamTopical.032 mL/100mL
EmulsionTopical.0315 mL/100mL
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility14.3 mg/mLALOGPS
logP0.89ALOGPS
logP1.08ChemAxon
logS-0.99ALOGPS
pKa (Strongest Acidic)7.46ChemAxon
pKa (Strongest Basic)-6.3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area57.53 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity36.6 m3·mol-1ChemAxon
Polarizability12.87 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-000i-0900000000-db13978cfcbc33c6da32
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-000i-1900000000-ed3a0258f14e4361b25c
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0pb9-9200000000-cdb54c91531419396213
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-000i-0900000000-db13978cfcbc33c6da32
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-000i-1900000000-ed3a0258f14e4361b25c
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0pb9-9200000000-cdb54c91531419396213
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-000i-0900000000-882b8375384be94a3491
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-000i-1900000000-25b2a170eaf9dd74c4a0
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0kw4-9300000000-e349b638bc98dcdf0ade
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-000i-0900000000-882b8375384be94a3491
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-000i-1900000000-25b2a170eaf9dd74c4a0
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0kw4-9300000000-e349b638bc98dcdf0ade
MS/MS Spectrum - ESI-TOF 10V, NegativeLC-MS/MSNot Available
MS/MS Spectrum - ESI-TOF 20V, NegativeLC-MS/MSNot Available
MS/MS Spectrum - ESI-TOF , NegativeLC-MS/MSNot Available
MS/MS Spectrum - ESI-TOF 10V, NegativeLC-MS/MSNot Available
MS/MS Spectrum - ESI-TOF 10V, NegativeLC-MS/MSNot Available
MS/MS Spectrum - ESI-TOF 20V, NegativeLC-MS/MSNot Available
MS/MS Spectrum - ESI-TOF , NegativeLC-MS/MSNot Available
MS/MS Spectrum - ESI-TOF 10V, NegativeLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-TOF , negativeLC-MS/MSsplash10-000i-0900000000-aa91c9c469ec39450435
LC-MS/MS Spectrum - LC-ESI-TOF , negativeLC-MS/MSsplash10-000i-0900000000-25b5b2bc87af9df04e91

Taxonomy

Description
This compound belongs to the class of organic compounds known as hydroxybenzaldehydes. These are organic aromatic compounds containing a benzene ring carrying an aldehyde group and a hydroxyl group.
Kingdom
Organic compounds
Super Class
Organic oxygen compounds
Class
Organooxygen compounds
Sub Class
Carbonyl compounds
Direct Parent
Hydroxybenzaldehydes
Alternative Parents
Catechols / Benzoyl derivatives / 1-hydroxy-4-unsubstituted benzenoids / 1-hydroxy-2-unsubstituted benzenoids / Organic oxides / Hydrocarbon derivatives
Substituents
Hydroxybenzaldehyde / Catechol / Benzoyl / 1-hydroxy-4-unsubstituted benzenoid / 1-hydroxy-2-unsubstituted benzenoid / Phenol / Benzenoid / Monocyclic benzene moiety / Organic oxide / Hydrocarbon derivative
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
dihydroxybenzaldehyde (CHEBI:50205) / an aryl aldehyde (CPD-7616)

Drug created on December 03, 2015 09:51 / Updated on August 02, 2018 06:22