Identification

Name
Ancrod
Accession Number
DB05099
Type
Small Molecule
Groups
Approved, Investigational
Description

Ancrod (current brand name: Viprinex) is a defibrinogenating agent derived from the venom of the Malayan pit viper. The defribrinogenation of blood results in an anticoagulant effect. Currently, Viprinex®/ancrod is not approved or marketed in any country, but is being investigated as a stroke treatment in worldwide clinical trials. In January 2005, the U.S. FDA granted a 'fast-track status' for investigation of ancrod use in patients suffering from acute ischemic stroke, a life threatening condition caused by the blockage of blood vessels supplying blood and oxygen to portions of the brain, for which phase III trials are currently being conducted.

Synonyms
Not Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
ViprinexLiquid70 unitIntravenous; SubcutaneousAbbott1986-12-312007-07-31Canada
Categories
UNII
EL55307L15
CAS number
9046-56-4
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

For the treatment of established deep vein thrombosis; central retinal and branch vein thrombosis; priapism; pulmonary hypertension of embolic origin; embolism after insertion of prosthetic cardiac valves; rethrombosis after thrombolytic therapy and rethrombosis after vascular surgery. It is also indicated for the prevention of deep venous thrombosis after repair of the fractured neck of a femur.

Structured Indications
Not Available
Pharmacodynamics

The decreased viscosity is directly attributable to lowered fibrinogen levels and leads to important improvements in blood flow and perfusion of the microcirculation.Ancrod decreases the blood viscosity in affected arteries, leads to less intense pain, improves physical limb mobility, and facilitates physical and ergo therapy. Finally, ancrod decreases the likelihood of local thrombotic events.

Mechanism of action

Ancrod's anticoagulant effects are through the rapid removal of fibrinogen from the blood within hours following ancrod administration. Ancrod specifically cleaves only the alpha chain of fibrinogen, producing the characteristic fibrinopeptides A, AP and AY, not the B-fibrinopeptide. The resulting fibrin polymers are imperfectly formed and much smaller in size (1 to 2 µm long) than the fibrin polymers produced by the action of thrombin. These ancrod-induced microthrombi are friable, unstable, urea-soluble and have significantly degraded a-chains. They do not cross-link to form thrombi. They are markedly susceptible to digestion by plasmin and are rapidly removed from circulation by either reticuloendothelial phagocytosis or normal fibrinolysis, or both. The blood viscosity in patients receiving ancrod is progressively reduced by 30 to 40%. Ancrod does not activate plagminogen and does not degrade preformed, fully cross-linked thrombin fibrin. Consequently, unlike fibrinolytic agents, ancrod can be used postoperatively. Unlike thrombin, ancrod does not directly activate Factor XIII, nor does it produce platelet aggregation nor cause the release of ADP, ATP, potassium, nor serotonin from platelets.

TargetActionsOrganism
UFibrinogen alpha chainNot AvailableHuman
Absorption

100% after i.v. dosing

Volume of distribution
Not Available
Protein binding

95% bound to erythrocytes

Metabolism
Not Available
Route of elimination
Not Available
Half life

3 to 5 hours

Clearance
Not Available
Toxicity

Currently, a new dosing strategy is being investigated in two international phase III trials as part of the 'Ancrod Stroke Program (ASP).' Each of these studies will enroll 650 patients and assess whether a brief, relatively rapid ancrod infusion with no maintenance dosing will be both effective and safe. Contraindications and precautions Known bleeding disorders of any origin or any unexplained excessive bleedings in the past. Platelet counts of less than 100,000 (even if asymptomatic), exemption : HIT (Heparin- induced thrombocytopenia). Planned surgery or short before delivery. Active ulcerations of the GIT. Any kind of malignant disease. Renal stones (increased likelihood of significant urological bleeding). Severe and uncontrolled arterial hypertension. Active pulmonary tuberculosis. Impaired fibrinolysis. Severe liver disease. Manifest or impending shock. I.M.-Injection : Ancrod should not be injected i.m., because of rapid induction of neutralizing antibodies and therefore drug resistance. Pregnancy Category X : Ancrod was not found to be teratogenic in animal studies, but some fetal deaths occurred as a result of placental hemorrhages in animals given high doses; therefore, it should not be used during pregnancy as the defibrinogenation mechanism of ancrod might be expected to interfere with the normal implantation of the fertilized egg. Side effects Hypersensitivity reactions : Local or generalized skin reactions (rash and urticaria); appearance of neutralizing antibodies to ancrod with partial or total loss of ancrod activity (drug resistance). Sometimes pain at injection site (normally mild)

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
(4R)-limonene(4R)-limonene may increase the anticoagulant activities of Ancrod.Investigational
AbciximabAbciximab may increase the anticoagulant activities of Ancrod.Approved
AceclofenacAceclofenac may increase the anticoagulant activities of Ancrod.Approved, Investigational
AcemetacinThe risk or severity of bleeding can be increased when Ancrod is combined with Acemetacin.Approved, Experimental, Investigational
AcenocoumarolAcenocoumarol may increase the anticoagulant activities of Ancrod.Approved, Investigational
Acetylsalicylic acidAcetylsalicylic acid may increase the anticoagulant activities of Ancrod.Approved, Vet Approved
AdapaleneAdapalene may increase the anticoagulant activities of Ancrod.Approved
AlclofenacAlclofenac may increase the anticoagulant activities of Ancrod.Approved, Withdrawn
AllylestrenolThe therapeutic efficacy of Ancrod can be decreased when used in combination with Allylestrenol.Approved
AlminoprofenAlminoprofen may increase the anticoagulant activities of Ancrod.Experimental
AloxiprinAloxiprin may increase the anticoagulant activities of Ancrod.Experimental
AlprostadilAlprostadil may increase the anticoagulant activities of Ancrod.Approved, Investigational
AlteplaseAlteplase may increase the anticoagulant activities of Ancrod.Approved
AltrenogestThe therapeutic efficacy of Ancrod can be decreased when used in combination with Altrenogest.Vet Approved
Aminosalicylic AcidAminosalicylic Acid may increase the anticoagulant activities of Ancrod.Approved
AnagrelideAnagrelide may increase the anticoagulant activities of Ancrod.Approved
AndrographolideAndrographolide may increase the anticoagulant activities of Ancrod.Investigational
AnisodamineAnisodamine may increase the anticoagulant activities of Ancrod.Investigational
AnistreplaseAnistreplase may increase the anticoagulant activities of Ancrod.Approved
AntipyrineAntipyrine may increase the anticoagulant activities of Ancrod.Approved, Investigational
Antithrombin III humanAncrod may increase the anticoagulant activities of Antithrombin III human.Approved
ApixabanApixaban may increase the anticoagulant activities of Ancrod.Approved
ApocyninApocynin may increase the anticoagulant activities of Ancrod.Investigational
ApremilastApremilast may increase the anticoagulant activities of Ancrod.Approved, Investigational
AprotininThe therapeutic efficacy of Ancrod can be decreased when used in combination with Aprotinin.Approved, Investigational, Withdrawn
ArdeparinArdeparin may increase the anticoagulant activities of Ancrod.Approved, Investigational, Withdrawn
ArgatrobanArgatroban may increase the anticoagulant activities of Ancrod.Approved, Investigational
AstaxanthinAstaxanthin may increase the anticoagulant activities of Ancrod.Investigational
AzapropazoneAzapropazone may increase the anticoagulant activities of Ancrod.Withdrawn
AzelastineAzelastine may increase the anticoagulant activities of Ancrod.Approved
Azficel-TThe risk or severity of adverse effects can be increased when Ancrod is combined with Azficel-T.Approved, Investigational
BalsalazideBalsalazide may increase the anticoagulant activities of Ancrod.Approved, Investigational
BatroxobinBatroxobin may increase the anticoagulant activities of Ancrod.Experimental
BecaplerminBecaplermin may increase the anticoagulant activities of Ancrod.Approved, Investigational
BemiparinBemiparin may increase the anticoagulant activities of Ancrod.Approved, Investigational
BendazacBendazac may increase the anticoagulant activities of Ancrod.Experimental
BenorilateBenorilate may increase the anticoagulant activities of Ancrod.Experimental
BenoxaprofenBenoxaprofen may increase the anticoagulant activities of Ancrod.Withdrawn
BenzydamineBenzydamine may increase the anticoagulant activities of Ancrod.Approved
BeraprostBeraprost may increase the anticoagulant activities of Ancrod.Investigational
BevoniumBevonium may increase the anticoagulant activities of Ancrod.Experimental
BivalirudinBivalirudin may increase the anticoagulant activities of Ancrod.Approved, Investigational
BrinaseBrinase may increase the anticoagulant activities of Ancrod.Experimental
BromfenacBromfenac may increase the anticoagulant activities of Ancrod.Approved
BucillamineBucillamine may increase the anticoagulant activities of Ancrod.Investigational
BufexamacBufexamac may increase the anticoagulant activities of Ancrod.Approved, Experimental
BuflomedilBuflomedil may increase the anticoagulant activities of Ancrod.Experimental
BumadizoneBumadizone may increase the anticoagulant activities of Ancrod.Experimental
ButylphthalideButylphthalide may increase the anticoagulant activities of Ancrod.Investigational
CangrelorCangrelor may increase the anticoagulant activities of Ancrod.Approved
CaplacizumabCaplacizumab may increase the anticoagulant activities of Ancrod.Investigational
Carbaspirin calciumCarbaspirin calcium may increase the anticoagulant activities of Ancrod.Experimental, Investigational
CarprofenCarprofen may increase the anticoagulant activities of Ancrod.Approved, Vet Approved, Withdrawn
CastanospermineCastanospermine may increase the anticoagulant activities of Ancrod.Experimental
CelecoxibCelecoxib may increase the anticoagulant activities of Ancrod.Approved, Investigational
CertoparinAncrod may increase the anticoagulant activities of Certoparin.Approved, Investigational
ChloroquineChloroquine may increase the anticoagulant activities of Ancrod.Approved, Investigational, Vet Approved
ChlorotrianiseneChlorotrianisene may decrease the anticoagulant activities of Ancrod.Investigational, Withdrawn
Choline magnesium trisalicylateCholine magnesium trisalicylate may increase the anticoagulant activities of Ancrod.Approved
CilostazolCilostazol may increase the anticoagulant activities of Ancrod.Approved, Investigational
Citric AcidCitric Acid may increase the anticoagulant activities of Ancrod.Approved, Nutraceutical, Vet Approved
ClonixinClonixin may increase the anticoagulant activities of Ancrod.Approved
ClopidogrelClopidogrel may increase the anticoagulant activities of Ancrod.Approved
CloricromenCloricromen may increase the anticoagulant activities of Ancrod.Experimental
ClorindioneClorindione may increase the anticoagulant activities of Ancrod.Experimental
Collagenase clostridium histolyticumThe risk or severity of adverse effects can be increased when Ancrod is combined with Collagenase clostridium histolyticum.Approved, Investigational
Conjugated estrogensConjugated estrogens may decrease the anticoagulant activities of Ancrod.Approved
CurcuminCurcumin may increase the anticoagulant activities of Ancrod.Approved, Investigational
Dabigatran etexilateDabigatran etexilate may increase the anticoagulant activities of Ancrod.Approved
DaidzeinDaidzein may decrease the anticoagulant activities of Ancrod.Experimental
DalteparinAncrod may increase the anticoagulant activities of Dalteparin.Approved
DanaparoidAncrod may increase the anticoagulant activities of Danaparoid.Approved, Withdrawn
DarexabanAncrod may increase the anticoagulant activities of Darexaban.Investigational
DasatinibDasatinib may increase the anticoagulant activities of Ancrod.Approved, Investigational
DeferasiroxThe risk or severity of adverse effects can be increased when Ancrod is combined with Deferasirox.Approved, Investigational
DefibrotideDefibrotide may increase the anticoagulant activities of Ancrod.Approved, Investigational
DemegestoneThe therapeutic efficacy of Ancrod can be decreased when used in combination with Demegestone.Experimental
Deoxycholic AcidThe risk or severity of adverse effects can be increased when Ancrod is combined with Deoxycholic Acid.Approved
DersalazineDersalazine may increase the anticoagulant activities of Ancrod.Investigational
DesirudinAncrod may increase the anticoagulant activities of Desirudin.Approved
DesmoteplaseDesmoteplase may increase the anticoagulant activities of Ancrod.Investigational
DesogestrelThe therapeutic efficacy of Ancrod can be decreased when used in combination with Desogestrel.Approved
DextranAncrod may increase the anticoagulant activities of Dextran.Approved, Investigational, Vet Approved
DiclofenacDiclofenac may increase the anticoagulant activities of Ancrod.Approved, Vet Approved
DicoumarolDicoumarol may increase the anticoagulant activities of Ancrod.Approved
DienestrolDienestrol may decrease the anticoagulant activities of Ancrod.Approved, Investigational
DienogestThe therapeutic efficacy of Ancrod can be decreased when used in combination with Dienogest.Approved
DiethylstilbestrolDiethylstilbestrol may decrease the anticoagulant activities of Ancrod.Approved, Investigational
DifenpiramideDifenpiramide may increase the anticoagulant activities of Ancrod.Experimental
DiflunisalDiflunisal may increase the anticoagulant activities of Ancrod.Approved, Investigational
DiphenadioneDiphenadione may increase the anticoagulant activities of Ancrod.Experimental
DipyridamoleDipyridamole may increase the anticoagulant activities of Ancrod.Approved
DitazoleDitazole may increase the anticoagulant activities of Ancrod.Approved, Withdrawn
Drotrecogin alfaDrotrecogin alfa may increase the anticoagulant activities of Ancrod.Approved, Investigational, Withdrawn
DroxicamDroxicam may increase the anticoagulant activities of Ancrod.Withdrawn
DuvelisibDuvelisib may increase the anticoagulant activities of Ancrod.Investigational
DydrogesteroneThe therapeutic efficacy of Ancrod can be decreased when used in combination with Dydrogesterone.Approved, Investigational, Withdrawn
E-6201E-6201 may increase the anticoagulant activities of Ancrod.Investigational
Edetic AcidEdetic Acid may increase the anticoagulant activities of Ancrod.Approved, Vet Approved
EdoxabanEdoxaban may increase the anticoagulant activities of Ancrod.Approved
EnoxaparinEnoxaparin may increase the anticoagulant activities of Ancrod.Approved
EpimestrolEpimestrol may decrease the anticoagulant activities of Ancrod.Experimental
EpinastineEpinastine may increase the anticoagulant activities of Ancrod.Approved, Investigational
EpirizoleEpirizole may increase the anticoagulant activities of Ancrod.Approved
EplivanserinEplivanserin may increase the anticoagulant activities of Ancrod.Investigational
eplivanserineeplivanserine may increase the anticoagulant activities of Ancrod.Investigational
EpoprostenolEpoprostenol may increase the anticoagulant activities of Ancrod.Approved
EptifibatideEptifibatide may increase the anticoagulant activities of Ancrod.Approved, Investigational
EquolEquol may decrease the anticoagulant activities of Ancrod.Investigational
EstradiolEstradiol may decrease the anticoagulant activities of Ancrod.Approved, Investigational, Vet Approved
Estradiol acetateEstradiol acetate may decrease the anticoagulant activities of Ancrod.Approved, Investigational, Vet Approved
Estradiol cypionateEstradiol cypionate may decrease the anticoagulant activities of Ancrod.Approved, Investigational, Vet Approved
Estradiol valerateEstradiol valerate may decrease the anticoagulant activities of Ancrod.Approved, Investigational, Vet Approved
EstriolEstriol may decrease the anticoagulant activities of Ancrod.Approved, Investigational, Vet Approved
Estrogens, esterifiedEstrogens, esterified may decrease the anticoagulant activities of Ancrod.Approved
EstroneEstrone may decrease the anticoagulant activities of Ancrod.Approved
EtanerceptEtanercept may increase the anticoagulant activities of Ancrod.Approved, Investigational
EthenzamideEthenzamide may increase the anticoagulant activities of Ancrod.Experimental
Ethinyl EstradiolEthinyl Estradiol may decrease the anticoagulant activities of Ancrod.Approved
Ethyl biscoumacetateAncrod may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
EthynodiolThe therapeutic efficacy of Ancrod can be decreased when used in combination with Ethynodiol.Experimental
EtodolacEtodolac may increase the anticoagulant activities of Ancrod.Approved, Investigational, Vet Approved
EtofenamateEtofenamate may increase the anticoagulant activities of Ancrod.Approved, Investigational
EtonogestrelThe therapeutic efficacy of Ancrod can be decreased when used in combination with Etonogestrel.Approved, Investigational
EtoricoxibEtoricoxib may increase the anticoagulant activities of Ancrod.Approved, Investigational
Evening primrose oilEvening primrose oil may increase the anticoagulant activities of Ancrod.Investigational, Nutraceutical
ExisulindExisulind may increase the anticoagulant activities of Ancrod.Investigational
FelbinacFelbinac may increase the anticoagulant activities of Ancrod.Experimental
FenbufenFenbufen may increase the anticoagulant activities of Ancrod.Approved
FenoprofenFenoprofen may increase the anticoagulant activities of Ancrod.Approved
FentiazacFentiazac may increase the anticoagulant activities of Ancrod.Experimental
FeprazoneFeprazone may increase the anticoagulant activities of Ancrod.Experimental
Ferulic acidFerulic acid may increase the anticoagulant activities of Ancrod.Experimental
FibrinolysinFibrinolysin may increase the anticoagulant activities of Ancrod.Investigational
FloctafenineFloctafenine may increase the anticoagulant activities of Ancrod.Approved, Withdrawn
FluindioneAncrod may increase the anticoagulant activities of Fluindione.Approved, Investigational
FlunixinFlunixin may increase the anticoagulant activities of Ancrod.Vet Approved
FlunoxaprofenFlunoxaprofen may increase the anticoagulant activities of Ancrod.Experimental
FlurbiprofenFlurbiprofen may increase the anticoagulant activities of Ancrod.Approved, Investigational
FondaparinuxAncrod may increase the anticoagulant activities of Fondaparinux.Approved, Investigational
Fondaparinux sodiumFondaparinux sodium may increase the anticoagulant activities of Ancrod.Approved, Investigational
GabexateAncrod may increase the anticoagulant activities of Gabexate.Investigational
GenisteinGenistein may decrease the anticoagulant activities of Ancrod.Investigational
GestodeneThe therapeutic efficacy of Ancrod can be decreased when used in combination with Gestodene.Approved, Investigational
GestonoroneThe therapeutic efficacy of Ancrod can be decreased when used in combination with Gestonorone.Experimental
GestrinoneThe therapeutic efficacy of Ancrod can be decreased when used in combination with Gestrinone.Approved
GuacetisalGuacetisal may increase the anticoagulant activities of Ancrod.Experimental
HeminHemin may increase the anticoagulant activities of Ancrod.Approved, Investigational
Hemoglobin crosfumarilHemoglobin crosfumaril may increase the anticoagulant activities of Ancrod.Experimental
HeparinHeparin may increase the anticoagulant activities of Ancrod.Approved, Investigational
HexestrolHexestrol may decrease the anticoagulant activities of Ancrod.Withdrawn
HigenamineHigenamine may increase the anticoagulant activities of Ancrod.Investigational
Hydroxyprogesterone caproateThe therapeutic efficacy of Ancrod can be decreased when used in combination with Hydroxyprogesterone caproate.Approved, Investigational
HydroxytyrosolHydroxytyrosol may increase the anticoagulant activities of Ancrod.Investigational
Ibritumomab tiuxetanThe risk or severity of adverse effects can be increased when Ancrod is combined with Ibritumomab tiuxetan.Approved, Investigational
IbrutinibThe risk or severity of adverse effects can be increased when Ibrutinib is combined with Ancrod.Approved
IbudilastIbudilast may increase the anticoagulant activities of Ancrod.Approved, Investigational
IbuprofenIbuprofen may increase the anticoagulant activities of Ancrod.Approved
IbuproxamIbuproxam may increase the anticoagulant activities of Ancrod.Withdrawn
IcatibantIcatibant may increase the anticoagulant activities of Ancrod.Approved, Investigational
Icosapent ethylIcosapent ethyl may increase the anticoagulant activities of Ancrod.Approved, Investigational, Nutraceutical
IdraparinuxAncrod may increase the anticoagulant activities of Idraparinux.Investigational
IfenprodilIfenprodil may increase the anticoagulant activities of Ancrod.Approved, Investigational, Withdrawn
IfetrobanIfetroban may increase the anticoagulant activities of Ancrod.Investigational
IloprostIloprost may increase the anticoagulant activities of Ancrod.Approved, Investigational
Imidazole salicylateImidazole salicylate may increase the anticoagulant activities of Ancrod.Experimental
IndobufenIndobufen may increase the anticoagulant activities of Ancrod.Investigational
IndomethacinIndomethacin may increase the anticoagulant activities of Ancrod.Approved, Investigational
IndoprofenIndoprofen may increase the anticoagulant activities of Ancrod.Withdrawn
IsoxicamIsoxicam may increase the anticoagulant activities of Ancrod.Withdrawn
KebuzoneKebuzone may increase the anticoagulant activities of Ancrod.Experimental
KetanserinKetanserin may increase the anticoagulant activities of Ancrod.Investigational
KetoprofenKetoprofen may increase the anticoagulant activities of Ancrod.Approved, Vet Approved
KetorolacKetorolac may increase the anticoagulant activities of Ancrod.Approved
LeflunomideLeflunomide may increase the anticoagulant activities of Ancrod.Approved, Investigational
LepirudinLepirudin may increase the anticoagulant activities of Ancrod.Approved
LetaxabanAncrod may increase the anticoagulant activities of Letaxaban.Investigational
LevonorgestrelThe therapeutic efficacy of Ancrod can be decreased when used in combination with Levonorgestrel.Approved, Investigational
LimaprostThe risk or severity of adverse effects can be increased when Limaprost is combined with Ancrod.Approved, Investigational
LinsidomineLinsidomine may increase the anticoagulant activities of Ancrod.Experimental
LisofyllineLisofylline may increase the anticoagulant activities of Ancrod.Investigational
LonazolacLonazolac may increase the anticoagulant activities of Ancrod.Experimental
LornoxicamLornoxicam may increase the anticoagulant activities of Ancrod.Approved, Investigational
LoxoprofenLoxoprofen may increase the anticoagulant activities of Ancrod.Approved, Investigational
LumiracoxibLumiracoxib may increase the anticoagulant activities of Ancrod.Approved, Investigational
Magnesium salicylateMagnesium salicylate may increase the anticoagulant activities of Ancrod.Approved
MasoprocolMasoprocol may increase the anticoagulant activities of Ancrod.Approved, Investigational
Meclofenamic acidMeclofenamic acid may increase the anticoagulant activities of Ancrod.Approved, Vet Approved
MedrogestoneThe therapeutic efficacy of Ancrod can be decreased when used in combination with Medrogestone.Approved
Medroxyprogesterone acetateThe therapeutic efficacy of Ancrod can be decreased when used in combination with Medroxyprogesterone acetate.Approved, Investigational
Mefenamic acidMefenamic acid may increase the anticoagulant activities of Ancrod.Approved
Megestrol acetateThe therapeutic efficacy of Ancrod can be decreased when used in combination with Megestrol acetate.Approved, Investigational, Vet Approved
MelagatranAncrod may increase the anticoagulant activities of Melagatran.Experimental
MeloxicamMeloxicam may increase the anticoagulant activities of Ancrod.Approved, Vet Approved
MesalazineMesalazine may increase the anticoagulant activities of Ancrod.Approved
MestranolMestranol may decrease the anticoagulant activities of Ancrod.Approved
MetamizoleMetamizole may increase the anticoagulant activities of Ancrod.Approved, Investigational, Withdrawn
MethallenestrilMethallenestril may decrease the anticoagulant activities of Ancrod.Experimental
Methyl salicylateMethyl salicylate may increase the anticoagulant activities of Ancrod.Approved, Vet Approved
MethylestrenoloneThe therapeutic efficacy of Ancrod can be decreased when used in combination with Methylestrenolone.Experimental
MilrinoneMilrinone may increase the anticoagulant activities of Ancrod.Approved
MizoribineMizoribine may increase the anticoagulant activities of Ancrod.Investigational
MofebutazoneMofebutazone may increase the anticoagulant activities of Ancrod.Experimental
MoxestrolMoxestrol may decrease the anticoagulant activities of Ancrod.Experimental
Mycophenolate mofetilMycophenolate mofetil may increase the anticoagulant activities of Ancrod.Approved, Investigational
Mycophenolic acidMycophenolic acid may increase the anticoagulant activities of Ancrod.Approved
NabumetoneNabumetone may increase the anticoagulant activities of Ancrod.Approved
NadroparinAncrod may increase the anticoagulant activities of Nadroparin.Approved, Investigational
NafamostatNafamostat may increase the anticoagulant activities of Ancrod.Approved, Investigational
NaftifineNaftifine may increase the anticoagulant activities of Ancrod.Approved
NaftopidilNaftopidil may increase the anticoagulant activities of Ancrod.Investigational
NaproxenNaproxen may increase the anticoagulant activities of Ancrod.Approved, Vet Approved
NepafenacNepafenac may increase the anticoagulant activities of Ancrod.Approved, Investigational
NifenazoneNifenazone may increase the anticoagulant activities of Ancrod.Experimental
Niflumic AcidNiflumic Acid may increase the anticoagulant activities of Ancrod.Approved
NimesulideNimesulide may increase the anticoagulant activities of Ancrod.Approved, Investigational, Withdrawn
NintedanibThe risk or severity of adverse effects can be increased when Ancrod is combined with Nintedanib.Approved
NitroaspirinNitroaspirin may increase the anticoagulant activities of Ancrod.Investigational
NomegestrolThe therapeutic efficacy of Ancrod can be decreased when used in combination with Nomegestrol.Approved
NorethisteroneThe therapeutic efficacy of Ancrod can be decreased when used in combination with Norethisterone.Approved
NorgestrienoneThe therapeutic efficacy of Ancrod can be decreased when used in combination with Norgestrienone.Experimental
ObinutuzumabThe risk or severity of adverse effects can be increased when Ancrod is combined with Obinutuzumab.Approved, Investigational
OlopatadineOlopatadine may increase the anticoagulant activities of Ancrod.Approved
OlsalazineOlsalazine may increase the anticoagulant activities of Ancrod.Approved
Omacetaxine mepesuccinateThe risk or severity of bleeding can be increased when Ancrod is combined with Omacetaxine mepesuccinate.Approved, Investigational
Omega-3 fatty acidsOmega-3 fatty acids may increase the anticoagulant activities of Ancrod.Approved, Nutraceutical
Omega-3-carboxylic acidsThe therapeutic efficacy of Ancrod can be increased when used in combination with Omega-3-carboxylic acids.Approved, Investigational
OrgoteinOrgotein may increase the anticoagulant activities of Ancrod.Vet Approved
OtamixabanAncrod may increase the anticoagulant activities of Otamixaban.Investigational
OxaprozinOxaprozin may increase the anticoagulant activities of Ancrod.Approved
OxyphenbutazoneOxyphenbutazone may increase the anticoagulant activities of Ancrod.Approved, Withdrawn
OzagrelOzagrel may increase the anticoagulant activities of Ancrod.Investigational
ParecoxibParecoxib may increase the anticoagulant activities of Ancrod.Approved
ParnaparinParnaparin may increase the anticoagulant activities of Ancrod.Approved, Investigational
ParthenolideParthenolide may increase the anticoagulant activities of Ancrod.Approved, Investigational
Pentaerythritol TetranitrateAncrod may increase the anticoagulant activities of Pentaerythritol Tetranitrate.Approved
Pentosan PolysulfatePentosan Polysulfate may increase the anticoagulant activities of Ancrod.Approved
PentoxifyllinePentoxifylline may increase the anticoagulant activities of Ancrod.Approved, Investigational
PhenindionePhenindione may increase the anticoagulant activities of Ancrod.Approved, Investigational
PhenprocoumonPhenprocoumon may increase the anticoagulant activities of Ancrod.Approved, Investigational
Phenyl aminosalicylatePhenyl aminosalicylate may increase the anticoagulant activities of Ancrod.Approved
PhenylbutazonePhenylbutazone may increase the anticoagulant activities of Ancrod.Approved, Vet Approved
PicotamidePicotamide may increase the anticoagulant activities of Ancrod.Experimental
PimecrolimusPimecrolimus may increase the anticoagulant activities of Ancrod.Approved, Investigational
PirfenidonePirfenidone may increase the anticoagulant activities of Ancrod.Approved, Investigational
PiroxicamPiroxicam may increase the anticoagulant activities of Ancrod.Approved, Investigational
PirprofenPirprofen may increase the anticoagulant activities of Ancrod.Experimental
Polyestradiol phosphatePolyestradiol phosphate may decrease the anticoagulant activities of Ancrod.Approved
PranoprofenPranoprofen may increase the anticoagulant activities of Ancrod.Experimental, Investigational
PrasugrelPrasugrel may increase the anticoagulant activities of Ancrod.Approved
ProgesteroneThe therapeutic efficacy of Ancrod can be decreased when used in combination with Progesterone.Approved, Vet Approved
ProglumetacinProglumetacin may increase the anticoagulant activities of Ancrod.Experimental
PromegestoneThe therapeutic efficacy of Ancrod can be decreased when used in combination with Promegestone.Experimental
PromestrienePromestriene may decrease the anticoagulant activities of Ancrod.Investigational
PropacetamolPropacetamol may increase the anticoagulant activities of Ancrod.Approved, Investigational
PropyphenazonePropyphenazone may increase the anticoagulant activities of Ancrod.Experimental
ProquazoneProquazone may increase the anticoagulant activities of Ancrod.Experimental
Protein CAncrod may increase the anticoagulant activities of Protein C.Approved
Protein S humanAncrod may increase the anticoagulant activities of Protein S human.Approved
ProtocatechualdehydeAncrod may increase the anticoagulant activities of Protocatechualdehyde.Approved
PTC299PTC299 may increase the anticoagulant activities of Ancrod.Investigational
QuinestrolQuinestrol may decrease the anticoagulant activities of Ancrod.Approved
RamatrobanRamatroban may increase the anticoagulant activities of Ancrod.Investigational
RelcovaptanRelcovaptan may increase the anticoagulant activities of Ancrod.Investigational
ResveratrolResveratrol may increase the anticoagulant activities of Ancrod.Approved, Experimental, Investigational
ReteplaseReteplase may increase the anticoagulant activities of Ancrod.Approved, Investigational
ReviparinAncrod may increase the anticoagulant activities of Reviparin.Approved, Investigational
RidogrelRidogrel may increase the anticoagulant activities of Ancrod.Approved
RivaroxabanAncrod may increase the anticoagulant activities of Rivaroxaban.Approved
RofecoxibRofecoxib may increase the anticoagulant activities of Ancrod.Approved, Investigational, Withdrawn
RosiglitazoneRosiglitazone may increase the anticoagulant activities of Ancrod.Approved, Investigational
SalicylamideSalicylamide may increase the anticoagulant activities of Ancrod.Approved
Salicylic acidSalicylic acid may increase the anticoagulant activities of Ancrod.Approved, Investigational, Vet Approved
SalsalateSalsalate may increase the anticoagulant activities of Ancrod.Approved
SarpogrelateSarpogrelate may increase the anticoagulant activities of Ancrod.Investigational
SaruplaseSaruplase may increase the anticoagulant activities of Ancrod.Experimental
SecoisolariciresinolSecoisolariciresinol may decrease the anticoagulant activities of Ancrod.Investigational
SelexipagSelexipag may increase the anticoagulant activities of Ancrod.Approved
SemapimodSemapimod may increase the anticoagulant activities of Ancrod.Investigational
SeratrodastSeratrodast may increase the anticoagulant activities of Ancrod.Approved
SerrapeptaseSerrapeptase may increase the anticoagulant activities of Ancrod.Investigational
SevofluraneSevoflurane may increase the anticoagulant activities of Ancrod.Approved, Vet Approved
SRT501SRT501 may increase the anticoagulant activities of Ancrod.Investigational
StreptokinaseStreptokinase may increase the anticoagulant activities of Ancrod.Approved, Investigational
SugammadexSugammadex may increase the anticoagulant activities of Ancrod.Approved
SulfasalazineSulfasalazine may increase the anticoagulant activities of Ancrod.Approved
SulindacSulindac may increase the anticoagulant activities of Ancrod.Approved, Investigational
SulodexideAncrod may increase the anticoagulant activities of Sulodexide.Approved, Investigational
SuprofenSuprofen may increase the anticoagulant activities of Ancrod.Approved, Withdrawn
SuxibuzoneSuxibuzone may increase the anticoagulant activities of Ancrod.Experimental
Synthetic Conjugated Estrogens, ASynthetic Conjugated Estrogens, A may decrease the anticoagulant activities of Ancrod.Approved
Synthetic Conjugated Estrogens, BSynthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Ancrod.Approved
TarenflurbilTarenflurbil may increase the anticoagulant activities of Ancrod.Investigational
TenecteplaseTenecteplase may increase the anticoagulant activities of Ancrod.Approved
TenidapTenidap may increase the anticoagulant activities of Ancrod.Experimental
TenoxicamTenoxicam may increase the anticoagulant activities of Ancrod.Approved
TepoxalinTepoxalin may increase the anticoagulant activities of Ancrod.Vet Approved
TeriflunomideTeriflunomide may increase the anticoagulant activities of Ancrod.Approved
TesmilifeneTesmilifene may increase the anticoagulant activities of Ancrod.Investigational
Testosterone cypionateThe therapeutic efficacy of Ancrod can be increased when used in combination with Testosterone cypionate.Approved
Testosterone enanthateThe therapeutic efficacy of Ancrod can be increased when used in combination with Testosterone enanthate.Approved
Testosterone undecanoateThe therapeutic efficacy of Ancrod can be increased when used in combination with Testosterone undecanoate.Approved, Investigational
Tiaprofenic acidTiaprofenic acid may increase the anticoagulant activities of Ancrod.Approved
TiboloneTibolone may increase the anticoagulant activities of Ancrod.Approved, Investigational
TicagrelorTicagrelor may increase the anticoagulant activities of Ancrod.Approved
TiclopidineTiclopidine may increase the anticoagulant activities of Ancrod.Approved
TinoridineTinoridine may increase the anticoagulant activities of Ancrod.Investigational
TinzaparinTinzaparin may increase the anticoagulant activities of Ancrod.Approved
TioclomarolTioclomarol may increase the anticoagulant activities of Ancrod.Experimental
TipranavirTipranavir may increase the anticoagulant activities of Ancrod.Approved, Investigational
TirofibanTirofiban may increase the anticoagulant activities of Ancrod.Approved
Tolfenamic AcidTolfenamic Acid may increase the anticoagulant activities of Ancrod.Approved, Investigational
TolmetinTolmetin may increase the anticoagulant activities of Ancrod.Approved
TositumomabThe risk or severity of adverse effects can be increased when Ancrod is combined with Tositumomab.Approved, Investigational
TranilastTranilast may increase the anticoagulant activities of Ancrod.Approved, Investigational
TrapidilTrapidil may increase the anticoagulant activities of Ancrod.Approved
TreprostinilTreprostinil may increase the anticoagulant activities of Ancrod.Approved, Investigational
TribenosideTribenoside may increase the anticoagulant activities of Ancrod.Experimental
TriflusalTriflusal may increase the anticoagulant activities of Ancrod.Approved, Investigational
TriptolideTriptolide may increase the anticoagulant activities of Ancrod.Investigational
Trolamine salicylateTrolamine salicylate may increase the anticoagulant activities of Ancrod.Approved
TroxerutinAncrod may increase the anticoagulant activities of Troxerutin.Investigational
UrokinaseUrokinase may increase the anticoagulant activities of Ancrod.Approved, Investigational, Withdrawn
ValdecoxibValdecoxib may increase the anticoagulant activities of Ancrod.Approved, Investigational, Withdrawn
Vitamin EVitamin E may increase the anticoagulant activities of Ancrod.Approved, Nutraceutical, Vet Approved
VorapaxarThe risk or severity of adverse effects can be increased when Vorapaxar is combined with Ancrod.Approved
WarfarinWarfarin may increase the anticoagulant activities of Ancrod.Approved
XimelagatranXimelagatran may increase the anticoagulant activities of Ancrod.Approved, Investigational, Withdrawn
ZaltoprofenZaltoprofen may increase the anticoagulant activities of Ancrod.Approved, Investigational
ZeranolZeranol may decrease the anticoagulant activities of Ancrod.Vet Approved
ZileutonZileuton may increase the anticoagulant activities of Ancrod.Approved, Investigational, Withdrawn
ZomepiracZomepirac may increase the anticoagulant activities of Ancrod.Withdrawn
Food Interactions
Not Available

References

General References
  1. Hennerici MG, Kay R, Bogousslavsky J, Lenzi GL, Verstraete M, Orgogozo JM: Intravenous ancrod for acute ischaemic stroke in the European Stroke Treatment with Ancrod Trial: a randomised controlled trial. Lancet. 2006 Nov 25;368(9550):1871-8. [PubMed:17126719]
  2. Kelton JG, Smith JW, Moffatt D, Santos A, Horsewood P: The interaction of ancrod with human platelets. Platelets. 1999;10(1):24-9. [PubMed:16801067]
External Links
PubChem Substance
347909946
Wikipedia
Ancrod
ATC Codes
B01AD09 — Ancrod

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1, 2RecruitingTreatmentDeafness / Ear Diseases / Hard of Hearing / Hearing Disorders / Hearing Loss, Sensorineural1
3CompletedNot AvailableBrain Infarction / Ischemia, Cerebral / Stroke, Acute1
3TerminatedTreatmentBrain Infarction / Ischemia, Cerebral / Strokes2

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
LiquidIntravenous; Subcutaneous70 unit
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Structural molecule activity
Specific Function
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function ...
Gene Name
FGA
Uniprot ID
P02671
Uniprot Name
Fibrinogen alpha chain
Molecular Weight
94972.455 Da

Drug created on October 21, 2007 16:23 / Updated on May 01, 2018 23:13