Simtuzumab

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Simtuzumab
Accession Number
DB12152
Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Description

Simtuzumab has been used in trials studying the treatment and basic science of Myelofibrosis, Pancreatic Cancer, Colorectal Cancer, and Idiopathic Pulmonary Fibrosis.

Protein chemical formula
Not Available
Protein average weight
Not Available
Sequences
Not Available
Synonyms
  • GS-6624
Categories
UNII
11Z5AIU653
CAS number
1318075-13-6

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbciximabThe risk or severity of adverse effects can be increased when Abciximab is combined with Simtuzumab.
AbituzumabThe risk or severity of adverse effects can be increased when Simtuzumab is combined with Abituzumab.
AbrilumabThe risk or severity of adverse effects can be increased when Simtuzumab is combined with Abrilumab.
AdalimumabThe risk or severity of adverse effects can be increased when Adalimumab is combined with Simtuzumab.
AdecatumumabThe risk or severity of adverse effects can be increased when Adecatumumab is combined with Simtuzumab.
AducanumabThe risk or severity of adverse effects can be increased when Simtuzumab is combined with Aducanumab.
AfelimomabThe risk or severity of adverse effects can be increased when Afelimomab is combined with Simtuzumab.
AlemtuzumabThe risk or severity of adverse effects can be increased when Alemtuzumab is combined with Simtuzumab.
AlirocumabThe risk or severity of adverse effects can be increased when Alirocumab is combined with Simtuzumab.
AmatuximabThe risk or severity of adverse effects can be increased when Simtuzumab is combined with Amatuximab.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Substance
347911289
Wikipedia
Simtuzumab

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedBasic ScienceIdiopathic Pulmonary Fibrosis (IPF)1
2CompletedPreventionPrimary Sclerosing Cholangitis (PSC)1
2CompletedTreatmentAgnogenic Myeloid Metaplasia1
2CompletedTreatmentFibrosis, Liver1
2CompletedTreatmentFibrosis, Liver / Hepatitis C Infection With HIV Co-Infection / Hepatitis C Viral Infection / Human Immunodeficiency Virus (HIV) Infections1
2CompletedTreatmentMalignant Neoplasm of Pancreas1
2CompletedTreatmentNon-Alcoholic Steatohepatitis (NASH)1
2TerminatedTreatmentColorectal Cancers1
2TerminatedTreatmentIdiopathic Pulmonary Fibrosis (IPF)2
2TerminatedTreatmentLiver Fibrosis Due to NASH / Non-Alcoholic Steatohepatitis (NASH)2

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Taxonomy

Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available

Drug created on October 20, 2016 15:29 / Updated on June 12, 2020 10:53

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