Fresolimumab

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Fresolimumab
Accession Number
DB12396
Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Description

Fresolimumab has been used in trials studying the treatment of Primary Brain Tumors, Metastatic Breast Cancer, Diffuse Systemic Sclerosis, Pleural Malignant Mesothelioma, and Primary Focal Segmental Glomerulosclerosis.

Protein chemical formula
Not Available
Protein average weight
Not Available
Sequences
Not Available
Synonyms
  • GC1008
Categories
UNII
375142VBIA
CAS number
948564-73-6

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
AbciximabThe risk or severity of adverse effects can be increased when Abciximab is combined with Fresolimumab.
AbituzumabThe risk or severity of adverse effects can be increased when Fresolimumab is combined with Abituzumab.
AdalimumabThe risk or severity of adverse effects can be increased when Adalimumab is combined with Fresolimumab.
AdecatumumabThe risk or severity of adverse effects can be increased when Adecatumumab is combined with Fresolimumab.
AducanumabThe risk or severity of adverse effects can be increased when Aducanumab is combined with Fresolimumab.
AfelimomabThe risk or severity of adverse effects can be increased when Afelimomab is combined with Fresolimumab.
AlemtuzumabThe risk or severity of adverse effects can be increased when Alemtuzumab is combined with Fresolimumab.
AlirocumabThe risk or severity of adverse effects can be increased when Alirocumab is combined with Fresolimumab.
AmatuximabThe risk or severity of adverse effects can be increased when Fresolimumab is combined with Amatuximab.
AMG 108The risk or severity of adverse effects can be increased when AMG 108 is combined with Fresolimumab.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Evidence Level

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Substance
347911330
Wikipedia
Fresolimumab

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentDiffuse Systemic Sclerosis1
1CompletedTreatmentGlomerulosclerosis, Focal Segmental1
1CompletedTreatmentIdiopathic Pulmonary Fibrosis (IPF)1
1RecruitingTreatmentOsteogenesis Imperfecta1
1TerminatedTreatmentAgnogenic Myeloid Metaplasia / Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase / Post-Essential Thrombocythemia Related Myelofibrosis / Primary Myelofibrosis1
1, 2RecruitingTreatmentStage IA Non-Small Cell Lung Carcinoma / Stage IB Non-Small Cell Lung Carcinoma1
2CompletedTreatmentMetastatic Breast Cancer (MBC)1
2CompletedTreatmentPleural Malignant Mesothelioma1
2CompletedTreatmentPrimary Brain Tumors1
2CompletedTreatmentPrimary Focal Segmental Glomerulosclerosis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Taxonomy

Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available

Drug created on October 20, 2016 16:13 / Updated on May 01, 2019 11:27