Nikkomycin Z

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Nikkomycin Z
Accession Number
DB12939
Type
Small Molecule
Groups
Investigational
Description

Nikkomycin Z has been used in trials studying the treatment and basic science of Coccidioidomycosis.

Structure
Thumb
Synonyms
Not Available
Categories
UNII
9Z22C3QQCJ
CAS number
59456-70-1
Weight
Average: 495.445
Monoisotopic: 495.160142025
Chemical Formula
C20H25N5O10
InChI Key
WWJFFVUVFNBJTN-VHDFTHOZSA-N
InChI
InChI=1S/C20H25N5O10/c1-7(13(28)9-3-2-8(26)6-22-9)11(21)17(31)24-12(19(32)33)16-14(29)15(30)18(35-16)25-5-4-10(27)23-20(25)34/h2-7,11-16,18,26,28-30H,21H2,1H3,(H,24,31)(H,32,33)(H,23,27,34)/t7-,11-,12-,13-,14-,15+,16+,18+/m0/s1
IUPAC Name
(2S)-2-[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanamido]-2-[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]acetic acid
SMILES
C[C@@H]([C@H](N)C(=O)N[C@@H]([C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(=O)NC1=O)C(O)=O)[C@H](O)C1=CC=C(O)C=N1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AgmatineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Agmatine.Experimental, Investigational
AmiodaroneThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Amiodarone.Approved, Investigational
AmlodipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Amlodipine.Approved
Amphotericin BThe therapeutic efficacy of Amphotericin B can be decreased when used in combination with Nikkomycin Z.Approved, Investigational
AmrinoneThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Amrinone.Approved
AranidipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Aranidipine.Approved, Investigational
AzelnidipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Azelnidipine.Approved, Investigational
AzimilideThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Azimilide.Investigational
BarnidipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Barnidipine.Approved
BencyclaneThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Bencyclane.Experimental
BenidipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Benidipine.Approved, Investigational
BepridilThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Bepridil.Approved, Withdrawn
BioallethrinThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Bioallethrin.Approved, Experimental
BuspironeThe metabolism of Buspirone can be decreased when combined with Nikkomycin Z.Approved, Investigational
BusulfanThe serum concentration of Busulfan can be increased when it is combined with Nikkomycin Z.Approved, Investigational
CarboxyamidotriazoleThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Carboxyamidotriazole.Investigational
CaroverineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Caroverine.Experimental
CilnidipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Cilnidipine.Approved, Investigational
CinnarizineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Cinnarizine.Approved, Investigational
CisaprideThe serum concentration of Cisapride can be increased when it is combined with Nikkomycin Z.Approved, Investigational, Withdrawn
ClevidipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Clevidipine.Approved, Investigational
CyclandelateThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Cyclandelate.Approved
CyclosporineThe metabolism of Cyclosporine can be decreased when combined with Nikkomycin Z.Approved, Investigational, Vet Approved
DarodipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Darodipine.Experimental
DidanosineDidanosine can cause a decrease in the absorption of Nikkomycin Z resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
DiltiazemThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Diltiazem.Approved, Investigational
DocetaxelThe metabolism of Docetaxel can be decreased when combined with Nikkomycin Z.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Nikkomycin Z.Approved, Investigational
DotarizineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Dotarizine.Investigational
EfonidipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Efonidipine.Approved, Investigational
EperisoneThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Eperisone.Approved, Investigational
EthosuximideThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Ethosuximide.Approved
EtravirineThe serum concentration of Etravirine can be increased when it is combined with Nikkomycin Z.Approved
FelodipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Felodipine.Approved, Investigational
FendilineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Fendiline.Withdrawn
Fish oilThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Fish oil.Approved, Nutraceutical
FlunarizineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Flunarizine.Approved
FluspirileneThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Fluspirilene.Approved, Investigational
FosphenytoinThe serum concentration of Nikkomycin Z can be decreased when it is combined with Fosphenytoin.Approved, Investigational
GabapentinThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Gabapentin.Approved, Investigational
GallopamilThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Gallopamil.Investigational
IsradipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Isradipine.Approved, Investigational
LacidipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Lacidipine.Approved, Investigational
LamotrigineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Lamotrigine.Approved, Investigational
LercanidipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Lercanidipine.Approved, Investigational
LevetiracetamThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Levetiracetam.Approved, Investigational
LidoflazineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Lidoflazine.Experimental
LoperamideThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Loperamide.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Nikkomycin Z.Approved
Magnesium sulfateThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Magnesium sulfate.Approved, Investigational, Vet Approved
ManidipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Manidipine.Approved, Investigational
MentholThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Menthol.Approved
MethsuximideThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Methsuximide.Approved
MibefradilThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Mibefradil.Investigational, Withdrawn
NaftopidilThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Naftopidil.Investigational
NicardipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Nicardipine.Approved, Investigational
NifedipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Nifedipine.Approved
NiguldipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Niguldipine.Experimental
NiludipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Niludipine.Experimental
NilvadipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Nilvadipine.Approved, Investigational
NimesulideThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Nimesulide.Approved, Investigational, Withdrawn
NimodipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Nimodipine.Approved, Investigational
NisoldipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Nisoldipine.Approved
NitrendipineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Nitrendipine.Approved, Investigational
NylidrinThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Nylidrin.Approved
OtiloniumThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Otilonium.Experimental, Investigational
PhenytoinThe serum concentration of Phenytoin can be increased when it is combined with Nikkomycin Z.Approved, Vet Approved
PinaveriumThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Pinaverium.Approved
PrenylamineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Prenylamine.Withdrawn
ProgesteroneThe absorption of Progesterone can be decreased when combined with Nikkomycin Z.Approved, Vet Approved
QuinidineThe serum concentration of Quinidine can be increased when it is combined with Nikkomycin Z.Approved, Investigational
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Nikkomycin Z.Approved, Investigational
RifabutinThe serum concentration of Rifabutin can be increased when it is combined with Nikkomycin Z.Approved, Investigational
RifampicinThe serum concentration of Rifampicin can be increased when it is combined with Nikkomycin Z.Approved
RifapentineThe serum concentration of Rifapentine can be increased when it is combined with Nikkomycin Z.Approved, Investigational
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Nikkomycin Z.Approved, Investigational
SeletracetamThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Seletracetam.Investigational
SolifenacinThe metabolism of Solifenacin can be decreased when combined with Nikkomycin Z.Approved
SucralfateSucralfate can cause a decrease in the absorption of Nikkomycin Z resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
SunitinibThe metabolism of Sunitinib can be decreased when combined with Nikkomycin Z.Approved, Investigational
TacrolimusThe metabolism of Tacrolimus can be decreased when combined with Nikkomycin Z.Approved, Investigational
TerodilineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Terodiline.Experimental
TetrahydropalmatineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Tetrahydropalmatine.Investigational
Tolfenamic AcidThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Tolfenamic Acid.Approved, Investigational
TranilastThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Tranilast.Approved, Investigational
TrimebutineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Trimebutine.Approved
TrimethadioneThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Trimethadione.Approved
VerapamilThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Verapamil.Approved
VinpocetineThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Vinpocetine.Investigational
WIN 55212-2The therapeutic efficacy of Nikkomycin Z can be increased when used in combination with WIN 55212-2.Experimental
ZiconotideThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Ziconotide.Approved
ZolpidemThe serum concentration of Zolpidem can be increased when it is combined with Nikkomycin Z.Approved
ZonisamideThe therapeutic efficacy of Nikkomycin Z can be increased when used in combination with Zonisamide.Approved, Investigational
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
456557
PubChem Substance
347829083
ChemSpider
401991
BindingDB
50089541
ChEBI
623918
ChEMBL
CHEMBL35306

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedTreatmentHealthy Volunteers1
1TerminatedBasic ScienceHealthy Volunteers1
1, 2TerminatedTreatmentCoccidioidomycosis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility4.47 mg/mLALOGPS
logP-1.2ALOGPS
logP-5.6ChemAxon
logS-2ALOGPS
pKa (Strongest Acidic)2.61ChemAxon
pKa (Strongest Basic)7.77ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count12ChemAxon
Hydrogen Donor Count8ChemAxon
Polar Surface Area244.87 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity111.84 m3·mol-1ChemAxon
Polarizability46.27 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Amino acids, peptides, and analogues
Direct Parent
Dipeptides
Alternative Parents
5'-deoxyribonucleosides / N-acyl-L-alpha-amino acids / Alpha amino acid amides / Glycosylamines / Pyrimidones / Hydroxypyridines / Aralkylamines / Hydropyrimidines / N-acyl amines / Vinylogous amides
show 18 more
Substituents
Alpha-dipeptide / 5'-deoxyribonucleoside / N-acyl-alpha-amino acid / N-acyl-alpha amino acid or derivatives / N-acyl-l-alpha-amino acid / Alpha-amino acid amide / Glycosyl compound / N-glycosyl compound / Alpha-amino acid or derivatives / Hydroxypyridine
show 38 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
nikkomycin (CHEBI:623918)

Drug created on October 20, 2016 19:29 / Updated on June 02, 2018 08:44