Prothipendyl

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Prothipendyl is a neuroleptic agent indicated in the treatment of restlessness and agitation in patients with underlying psychiatric conditions.

Generic Name
Prothipendyl
DrugBank Accession Number
DB12958
Background

Prothipendyl has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders.

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 285.41
Monoisotopic: 285.129968798
Chemical Formula
C16H19N3S
Synonyms
  • Prothipendyl
  • Prothipendylum
  • Protipendilo
External IDs
  • AY 56031
  • D 206
  • LG 206
  • MH 05101

Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Treatment ofPsychomotor agitation••••••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
1,2-BenzodiazepineThe risk or severity of CNS depression can be increased when 1,2-Benzodiazepine is combined with Prothipendyl.
AcetazolamideThe risk or severity of CNS depression can be increased when Acetazolamide is combined with Prothipendyl.
AcetophenazineThe risk or severity of CNS depression can be increased when Acetophenazine is combined with Prothipendyl.
AgomelatineThe risk or severity of CNS depression can be increased when Agomelatine is combined with Prothipendyl.
AlfentanilThe risk or severity of CNS depression can be increased when Alfentanil is combined with Prothipendyl.
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Prothipendyl hydrochloride7610629RVH1225-65-6CQJSAKJMCVSEGU-UHFFFAOYSA-N
Prothipendyl hydrochloride monohydrate9G1ILH80SA70145-94-7YATJECIBCQMRMY-UHFFFAOYSA-N
International/Other Brands
Dominal / Tumovan

Categories

ATC Codes
N05AX07 — Prothipendyl
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as alkyldiarylamines. These are tertiary alkylarylamines having two aryl and one alkyl groups attached to the amino group.
Kingdom
Organic compounds
Super Class
Organic nitrogen compounds
Class
Organonitrogen compounds
Sub Class
Amines
Direct Parent
Alkyldiarylamines
Alternative Parents
Diarylthioethers / Benzothiazines / Pyridines and derivatives / Imidolactams / Benzenoids / 1,4-thiazines / Heteroaromatic compounds / Trialkylamines / Azacyclic compounds / Organopnictogen compounds
show 1 more
Substituents
Alkyldiarylamine / Aromatic heteropolycyclic compound / Aryl thioether / Azacycle / Benzenoid / Benzothiazine / Diarylthioether / Heteroaromatic compound / Hydrocarbon derivative / Imidolactam
show 6 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
5O6VWA87VA
CAS number
303-69-5
InChI Key
JTTAUPUMOLRVRA-UHFFFAOYSA-N
InChI
InChI=1S/C16H19N3S/c1-18(2)11-6-12-19-13-7-3-4-8-14(13)20-15-9-5-10-17-16(15)19/h3-5,7-10H,6,11-12H2,1-2H3
IUPAC Name
dimethyl(3-{9-thia-2,4-diazatricyclo[8.4.0.0^{3,8}]tetradeca-1(14),3(8),4,6,10,12-hexaen-2-yl}propyl)amine
SMILES
CN(C)CCCN1C2=CC=CC=C2SC2=C1N=CC=C2

References

General References
  1. DIMDI Drug Product Information: Dominal (prothipendyl hydrochloride) for oral use [Link]
PubChem Compound
14670
PubChem Substance
347829098
ChemSpider
14002
RxNav
55244
ChEBI
135182
ChEMBL
CHEMBL2111030
ZINC
ZINC000000001996
Wikipedia
Prothipendyl

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3TerminatedTreatmentAnxiety Disorders / Dementia / Depression / Psychosomatic Disorders / Schizophrenia1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionOral50 mg/mL
Tablet, coatedOral40 MG
Tablet, film coatedOral80 MG
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.128 mg/mLALOGPS
logP3.53ALOGPS
logP3.31Chemaxon
logS-3.4ALOGPS
pKa (Strongest Basic)9.2Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area19.37 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity87.11 m3·mol-1Chemaxon
Polarizability32.44 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSsplash10-0c00-6390000000-6cc7936806d42f688af1
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-000i-0090000000-c7965e64a88aa72675b1
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-001i-0090000000-8281ec4ab9adc23fdb20
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-000l-2090000000-f5b19bf48378d8b079ad
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-001i-0390000000-c07dde81ef9332e26d42
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0zi9-4590000000-71157624d538c77396ea
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0002-0920000000-af7459a8081ffc406d5b
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-176.0145433
predicted
DarkChem Lite v0.1.0
[M-H]-157.08006
predicted
DeepCCS 1.0 (2019)
[M+H]+176.2982433
predicted
DarkChem Lite v0.1.0
[M+H]+159.43806
predicted
DeepCCS 1.0 (2019)
[M+Na]+176.2024433
predicted
DarkChem Lite v0.1.0
[M+Na]+165.5312
predicted
DeepCCS 1.0 (2019)

Drug created at October 21, 2016 01:35 / Updated at March 18, 2024 16:24