Anxiety Disorders

Also known as: Anxiety Disorder / Anxiety NOS

DrugDrug NameDrug Description
DB00490BuspironeAn anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the benzodiazepines, but it has an efficacy comparable to diazepam. [PubChem]
DB00475ChlordiazepoxideAn anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.
DB00829DiazepamA benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. (From Martindale, The Extra Pharmacopoeia, 30th ed, p589)
DB00186LorazepamA benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.
DB00371MeprobamateA carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia but has largely been superseded by the benzodiazepines. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603) Meprobamate is a controlled substance in the U.S.
DB00842OxazepamOxazepam is an intermediate-acting benzodiazepine used to treat alcohol withdrawal and anxiety disorders. Oxazepam is also the metabolite of other benzodiazpines.
DrugDrug NameTargetType
DB00490Buspirone5-hydroxytryptamine receptor 1Atarget
DB00490BuspironeD(2) dopamine receptortarget
DB00490BuspironeCytochrome P450 3A4enzyme
DB00490BuspironeCytochrome P450 3A5enzyme
DB00490BuspironeCytochrome P450 3A7enzyme
DB00490BuspironeMultidrug resistance protein 1transporter
DB00490BuspironeCytochrome P450 2D6enzyme
DB00475ChlordiazepoxideCytochrome P450 3A4enzyme
DB00475ChlordiazepoxideCytochrome P450 2D6enzyme
DB00475ChlordiazepoxideGABA-A receptor (anion channel)target
DB00829DiazepamTranslocator proteintarget
DB00829DiazepamGamma-aminobutyric acid receptor subunit alpha-1target
DB00829DiazepamGamma-aminobutyric acid receptor subunit alpha-2target
DB00829DiazepamGamma-aminobutyric acid receptor subunit alpha-3target
DB00829DiazepamCytochrome P450 3A4enzyme
DB00829DiazepamCytochrome P450 1A2enzyme
DB00829DiazepamSerum albumincarrier
DB00829DiazepamCytochrome P450 2C9enzyme
DB00829DiazepamCytochrome P450 2C19enzyme
DB00829DiazepamCytochrome P450 3A5enzyme
DB00829DiazepamCytochrome P450 3A7enzyme
DB00829DiazepamGamma-aminobutyric acid receptor subunit alpha-5target
DB00829DiazepamGamma-aminobutyric acid receptor subunit beta-1target
DB00829DiazepamGamma-aminobutyric acid receptor subunit beta-2target
DB00829DiazepamGamma-aminobutyric acid receptor subunit beta-3target
DB00829DiazepamGamma-aminobutyric acid receptor subunit gamma-1target
DB00829DiazepamGamma-aminobutyric acid receptor subunit gamma-2target
DB00829DiazepamGamma-aminobutyric acid receptor subunit gamma-3target
DB00829DiazepamGamma-aminobutyric acid receptor subunit deltatarget
DB00829DiazepamGamma-aminobutyric acid receptor subunit epsilontarget
DB00829DiazepamGamma-aminobutyric acid receptor subunit pitarget
DB00829DiazepamGamma-aminobutyric acid receptor subunit rho-1target
DB00829DiazepamGamma-aminobutyric acid receptor subunit rho-2target
DB00829DiazepamGamma-aminobutyric acid receptor subunit rho-3target
DB00829DiazepamGamma-aminobutyric acid receptor subunit thetatarget
DB00829DiazepamMultidrug resistance protein 1transporter
DB00829DiazepamCytochrome P450 2B6enzyme
DB00829DiazepamProstaglandin G/H synthase 1enzyme
DB00829DiazepamCytochrome P450 2C18enzyme
DB00829DiazepamCytochrome P450 2C8enzyme
DB00829DiazepamCytochrome P450 2E1enzyme
DB00829DiazepamGABA-A receptor (anion channel)target
DB00186LorazepamTranslocator proteintarget
DB00186LorazepamUDP-glucuronosyltransferase 2B15enzyme
DB00186LorazepamGABA-A receptor (anion channel)target
DB00371MeprobamateGamma-aminobutyric acid receptor subunit alpha-1target
DB00371MeprobamateGamma-aminobutyric acid receptor subunit alpha-2target
DB00371MeprobamateGamma-aminobutyric acid receptor subunit alpha-3target
DB00371MeprobamateGamma-aminobutyric acid receptor subunit alpha-4target
DB00371MeprobamateGamma-aminobutyric acid receptor subunit alpha-5target
DB00371MeprobamateGamma-aminobutyric acid receptor subunit alpha-6target
DB00371MeprobamateCytochrome P450 2C19enzyme
DB00371MeprobamateCytochrome P450 2E1enzyme
DB00371MeprobamateGABA-A receptor (anion channel)target
DB00842OxazepamCytochrome P450 3A4enzyme
DB00842OxazepamCytochrome P450 3A43enzyme
DB00842OxazepamCytochrome P450 3A7enzyme
DB00842OxazepamUDP-glucuronosyltransferase 2B15enzyme
DB00842OxazepamUDP-glucuronosyltransferase 2B7enzyme
DB00842OxazepamUDP-glucuronosyltransferase 1-9enzyme
DB00842OxazepamGamma-aminobutyric acid receptor subunit alpha-1target
DB00842OxazepamGamma-aminobutyric acid receptor subunit alpha-2target
DB00842OxazepamGamma-aminobutyric acid receptor subunit alpha-3target
DB00842OxazepamGamma-aminobutyric acid receptor subunit alpha-4target
DB00842OxazepamGamma-aminobutyric acid receptor subunit alpha-5target
DB00842OxazepamGamma-aminobutyric acid receptor subunit alpha-6target
DB00842OxazepamGamma-aminobutyric acid receptor subunit beta-1target
DB00842OxazepamGamma-aminobutyric acid receptor subunit beta-2target
DB00842OxazepamGamma-aminobutyric acid receptor subunit beta-3target
DB00842OxazepamGamma-aminobutyric acid receptor subunit gamma-1target
DB00842OxazepamGamma-aminobutyric acid receptor subunit gamma-2target
DB00842OxazepamGamma-aminobutyric acid receptor subunit gamma-3target
DB00842OxazepamGamma-aminobutyric acid receptor subunit deltatarget
DB00842OxazepamGamma-aminobutyric acid receptor subunit epsilontarget
DB00842OxazepamGamma-aminobutyric acid receptor subunit pitarget
DB00842OxazepamGamma-aminobutyric acid receptor subunit rho-1target
DB00842OxazepamGamma-aminobutyric acid receptor subunit rho-2target
DB00842OxazepamGamma-aminobutyric acid receptor subunit thetatarget
DB00842OxazepamGamma-aminobutyric acid receptor subunit rho-3target
DB00842OxazepamGABA-A receptor (anion channel)target
DrugDrug NamePhaseStatusCount
DB00404Alprazolam1Completed4
DB00260Cycloserine1Active Not Recruiting1
DB01175Escitalopram1Completed1
DB01175Escitalopram1Unknown Status1
DB12542GSK-3562781Completed1
DB12341LY-24563021Withdrawn1
DB00834Mifepristone1Active Not Recruiting1
DB00184Nicotine1Completed2
DB11196Inositol1 / 2Not Yet Recruiting1
DB00834Mifepristone1 / 2Completed1
DB13994AZD-73252Completed2
DB00404Alprazolam2Completed1
DB00181Baclofen2Completed1
DB00490Buspirone2Terminated1
DB00515Cisplatin2Completed1
DB00843Donepezil2Completed1
DB12666Emapunil2Completed1
DB01175Escitalopram2Completed1
DB00472Fluoxetine2Completed1
DB00441Gemcitabine2Completed1
DB01322Kava2Completed1
DB01322Kava2Terminated1
DB01221Ketamine2Completed1
DB00555Lamotrigine2Completed1
DB01202Levetiracetam2Completed2
DB00186Lorazepam2Completed1
DB04829Lysergic Acid Diethylamide2Recruiting1
DB12238MK-07772Completed2
DB00683Midazolam2Completed1
DB12643Nelivaptan2Completed1
DB11788Neuropeptide Y2Completed1
DB00107Oxytocin2Enrolling by Invitation2
DB00715Paroxetine2Completed3
DB12572Pexacerfont2Completed1
DB00740Riluzole2Terminated1
DB01104Sertraline2Completed1
DB01323St. John's Wort2Completed1
DB00285Venlafaxine2Terminated1
DB09068Vortioxetine2Completed1
DB01323St. John's Wort2 / 3Completed1
DB00285Venlafaxine2 / 3Completed1
DB09068Vortioxetine2 / 3Recruiting1
DB00659Acamprosate3Terminated1
DB06594Agomelatine3Terminated1
DB00404Alprazolam3Terminated1
DB06288Amisulpride3Terminated1
DB00321Amitriptyline3Terminated1
DB01238Aripiprazole3Terminated1
DB00810Biperiden3Terminated1
DB01558Bromazepam3Terminated1
DB09017Brotizolam3Terminated1
DB01156Bupropion3Terminated1
DB00490Buspirone3Terminated1
DB00564Carbamazepine3Terminated1
DB01563Chloral hydrate3Terminated1
DB01239Chlorprothixene3Terminated1
DB00215Citalopram3Terminated1
DB00349Clobazam3Terminated1
DB01242Clomipramine3Terminated1
DB01068Clonazepam3Terminated1
DB00363Clozapine3Terminated1
DB04839Cyproterone acetate3Unknown Status1
DB00829Diazepam3Terminated1
DB01075Diphenhydramine3Terminated1
DB00843Donepezil3Terminated1
DB01142Doxepin3Terminated1
DB00476Duloxetine3Completed5
DB00476Duloxetine3Terminated1
DB01175Escitalopram3Completed2
DB01175Escitalopram3Terminated2
DB00472Fluoxetine3Completed1
DB00472Fluoxetine3Terminated1
DB00875Flupentixol3Terminated1
DB00623Fluphenazine3Terminated1
DB00690Flurazepam3Terminated1
DB04842Fluspirilene3Terminated1
DB00176Fluvoxamine3Completed1
DB00176Fluvoxamine3Terminated1
DB00996Gabapentin3Terminated1
DB00674Galantamine3Terminated1
DB00502Haloperidol3Terminated1
DB00557Hydroxyzine3Terminated1
DB12105Imagabalin3Terminated1
DB00458Imipramine3Terminated1
DB06218Lacosamide3Terminated1
DB00555Lamotrigine3Terminated1
DB01202Levetiracetam3Terminated1
DB01356Lithium cation3Terminated1
DB00186Lorazepam3Terminated1
DB00934Maprotiline3Terminated1
DB01065Melatonin3Terminated1
DB09224Melperone3Terminated1
DB01043Memantine3Completed1
DB01043Memantine3Terminated1
DB01403Methotrimeprazine3Terminated1
DB00422Methylphenidate3Recruiting1
DB06148Mianserin3Terminated1
DB00683Midazolam3Terminated1
DB00370Mirtazapine3Terminated1
DB01171Moclobemide3Terminated1
DB05562Naluzotan3Completed1
DB00699Nicergoline3Terminated1
DB01595Nitrazepam3Terminated1
DB00540Nortriptyline3Terminated1
DB00334Olanzapine3Terminated1
DB00842Oxazepam3Terminated1
DB00776Oxcarbazepine3Terminated1
DB01267Paliperidone3Terminated1
DB00715Paroxetine3Terminated2
DB00850Perphenazine3Terminated1
DB01174Phenobarbital3Terminated1
DB00252Phenytoin3Terminated1
DB01100Pimozide3Terminated1
DB09286Pipamperone3Terminated1
DB09210Piracetam3Terminated1
DB00230Pregabalin3Terminated1
DB01069Promethazine3Terminated1
DB00571Propranolol3Recruiting1
DB01224Quetiapine3Completed3
DB01224Quetiapine3Terminated1
DB00234Reboxetine3Terminated1
DB00734Risperidone3Completed2
DB00734Risperidone3Terminated1
DB00989Rivastigmine3Terminated1
DB06144Sertindole3Terminated1
DB01104Sertraline3Terminated1
DB01104Sertraline3Unknown Status1
DB00391Sulpiride3Terminated1
DB00231Temazepam3Terminated1
DB00679Thioridazine3Terminated1
DB00906Tiagabine3Completed2
DB13025Tiapride3Terminated1
DB00273Topiramate3Terminated1
DB00752Tranylcypromine3Terminated1
DB00656Trazodone3Terminated1
DB00897Triazolam3Terminated1
DB00726Trimipramine3Terminated1
DB13196Valerian3Unknown Status1
DB00313Valproic Acid3Terminated1
DB00285Venlafaxine3Completed2
DB00285Venlafaxine3Terminated1
DB14691Willow bark3Completed1
DB00962Zaleplon3Terminated1
DB01593Zinc3Terminated1
DB00246Ziprasidone3Terminated1
DB00425Zolpidem3Terminated1
DB01198Zopiclone3Terminated1
DB01624Zuclopenthixol3Terminated1
DB06470clomethiazole3Terminated1
DB00404Alprazolam4Completed1
DB00404Alprazolam4Withdrawn1
DB00321Amitriptyline4Completed1
DB01238Aripiprazole4Completed1
DB00490Buspirone4Withdrawn1
DB00215Citalopram4Recruiting1
DB01175Escitalopram4Active Not Recruiting1
DB01175Escitalopram4Completed2
DB01175Escitalopram4Recruiting1
DB00472Fluoxetine4Completed1
DB00472Fluoxetine4Recruiting1
DB00176Fluvoxamine4Recruiting1
DB01221Ketamine4Recruiting1
DB00186Lorazepam4Completed1
DB00683Midazolam4Recruiting1
DB00834Mifepristone4Completed1
DB00334Olanzapine4Completed1
DB00107Oxytocin4Completed1
DB00715Paroxetine4Recruiting1
DB00230Pregabalin4Completed1
DB00571Propranolol4Completed1
DB01224Quetiapine4Completed2
DB00734Risperidone4Completed1
DB05271Rotigotine4Recruiting1
DB01104Sertraline4Completed1
DB01104Sertraline4Recruiting1
DB01104Sertraline4Terminated1
DB00285Venlafaxine4Completed2
DB00490BuspironeNot AvailableUnknown Status1
DB01151DesipramineNot AvailableCompleted1
DB01075DiphenhydramineNot AvailableRecruiting1
DB00476DuloxetineNot AvailableActive Not Recruiting1
DB01175EscitalopramNot AvailableCompleted1
DB00472FluoxetineNot AvailableActive Not Recruiting1
DB00996GabapentinNot AvailableCompleted1
DB00741HydrocortisoneNot AvailableCompleted1
DB00281LidocaineNot AvailableCompleted1
DB00186LorazepamNot AvailableCompleted1
DB14009Medical CannabisNot AvailableRecruiting1
DB01017MinocyclineNot AvailableRecruiting1
DB00107OxytocinNot AvailableSuspended1
DB00715ParoxetineNot AvailableActive Not Recruiting1
DB00715ParoxetineNot AvailableCompleted1
DB00715ParoxetineNot AvailableUnknown Status1
DB00457PrazosinNot AvailableCompleted1
DB00750PrilocaineNot AvailableCompleted1
DB01224QuetiapineNot AvailableCompleted1
DB00285VenlafaxineNot AvailableActive Not Recruiting1