| Butalbital | A barbiturate drug used for symptomatic treatment of tension-type headache in various combinations with acetaminophen, aspirin, caffeine, and codeine. |
| Lorazepam | A long-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures. |
| Ethchlorvynol | A sedative hypnotic agent used for the short-term management of insomnia. |
| Ziprasidone | An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia. |
| Talbutal | For use as a sedative and hypnotic. |
| Pentobarbital | A barbiturate drug used to induce sleep, cause sedation, and control certain types of seizures. |
| Olanzapine | An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders. |
| Clobazam | A benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome. |
| Clozapine | An antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients. |
| Meprobamate | An anxiolytic drug used for the short-term management of anxiety symptoms. |
| Sulpiride | Sulpiride is indicated for the treatment of schizophrenia. |
| Eszopiclone | A sedative-hypnotic used in the treatment of insomnia, improving both the latency phase and the maintenance phase of sleep. |
| Alprazolam | A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression. |
| Loxapine | A antipsychotic used for the treatment of schizophrenia. |
| Remoxipride | Remoxipride is an atypical antipsychotic once used for the treatment of schizophrenia. |
| Secobarbital | A barbiturate used for the short-term treatment of insomnia. |
| Promazine | A phenothiazine used to manage schizophrenia. |
| Zolpidem | A sedative hypnotic used for the short-term treatment of insomnia to improve sleep latency. |
| Prochlorperazine | A phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. |
| Droperidol | A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting. |
| Methohexital | An anesthetic used to induce deep sedation. |
| Chlordiazepoxide | A benzodiazepine used to treat the withdrawal symptoms of acute alcoholism, to treat preoperative anxiety, and to treat anxiety over a short term period. |
| Chlorpromazine | A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. |
| Buspirone | An anxiolytic agent used for short-term treatment of generalized anxiety and second-line treatment of depression. |
| Haloperidol | An antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. |
| Triflupromazine | Used mainly in the management of psychoses. Also used to control nausea and vomiting. |
| Adinazolam | For the treatment of anxiety and status epilepticus. |
| Hydroxyzine | An antihistamine used to treat anxiety and tension associated with psychoneuroses, as well as allergic conditions such as pruritus and chronic urticaria. |
| Thiopental | A barbiturate used to induce general anesthesia, treat convulsions, and reduce intracranial pressure. |
| Fluphenazine | A phenothiazine used to treat patients requiring long-term neuroleptic therapy. |
| Dexmedetomidine | An alpha-2 agonist used for sedation during various procedures. |
| Thioridazine | A phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. |
| Midazolam | A short-acting injectable benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders. |
| Flurazepam | A long-acting benzodiazepine with a rapid onset of action that is commonly used to treat insomnia. |
| Risperidone | A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. |
| Propiomazine | Propiomazine is largely used for its antihistamininc sleep inducing effects in treating insomnia. |
| Primidone | An antiepileptic used to treat grand mal, psychomotor, and focal epileptic seizures. |
| Halazepam | Used to relieve anxiety, nervousness, and tension associated with anxiety disorders. |
| Diazepam | A long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. |
| Trifluoperazine | A phenothiazine used to treat depression, anxiety, and agitation. |
| Oxazepam | An intermediate-acting benzodiazepine with slow onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawals, and insomnia. |
| Methylphenobarbital | For the relief of anxiety, tension, and apprehension, also used as an anticonvulsant for the treatment of epilepsy. |
| Perphenazine | A phenothiazine used to treat schizophrenia as well as nausea and vomiting. |
| Flupentixol | A thioxanthene neuroleptic used to treat schizophrenia and depression. |
| Triazolam | A benzodiazepine used for short term treatment of insomnia. |
| Mesoridazine | A phenothiazine antipsychotic used to treat schizophrenia, organic brain disorders, alcoholism, and psychoneuroses. |
| Zaleplon | A sedative used for short term treatment of insomnia in adults. |
| Ramelteon | A melatonin receptor agonist used to treat insomnia. |
| Acetophenazine | For the treatment of disorganized and psychotic thinking. Also used to help treat false perceptions (e.g. hallucinations or delusions.) |
| Melatonin | An endogenous hormone produced by the pineal gland that regulates sleep-wake cycles and when provided exogenously has beneficial effects on sleep-onset latency; available as an over-the-counter supplement. |
| Pimozide | An antipsychotic used to manage debilitating motor and phonic tics in patients with Tourette's Disorder. |
| Methyprylon | For the treatment of insomnia. |
| Thiamylal | Used for the production of complete anaesthesia of short duration, for the induction of general anaesthesia, and for inducing a hypnotic state. |
| Phenobarbital | A long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures. |
| Zopiclone | A nonbenzodiazepine hypnotic used for the short-term management of insomnia. |
| Estazolam | A benzodiazepine used for the short-term management of insomnia. |
| Quetiapine | A psychotropic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder. |
| Aripiprazole | An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. |
| Chlorprothixene | For treatment of psychotic disorders (e.g. schizophrenia) and of acute mania occuring as part of bipolar disorders. |
| Paliperidone | An atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders. |
| Amobarbital | A barbiturate derivative used for the induction of sedation during procedures, short-term management of insomnia, and acute management of refractory tonic-clonic seizures. |
| Aprobarbital | Aprobarbital is a barbiturate derivative synthesized in the 1920s by Ernst Preiswerk. It was determined that the substance was capable of demonstrating sedative, hypnotic, and anticonvulsant effects. A primary treatment... |
| Butobarbital | For the treatment of insomnia. |
| Heptabarbital | Used mainly for sedation and hypnosis. |
| Hexobarbital | For the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful... |
| Methotrimeprazine | A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. |
| Glutethimide | For the treatment of insomnia. |
| Barbital | A long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice... |
| Camazepam | Camazepam has been used in placebo controlled studies for the treatment of patients suffering from anxiety and depression. |
| Dichloralphenazone | Dichloralphenazone is a sedative composed of chloral hydrate and phenazone. It is typically found in combination products Nodolor and Midrin containing isometheptene and acetaminophen used for the relief of tension... |
| Flunitrazepam | For short-term treatment of severe insomnias, that are not responsive to other hypnotics. |
| Ethyl loflazepate | Not Available |
| Cloxazolam | Used primarily as an anti-anxiety agent. Typically used short term, and may be given as a single dose of up to 100mcg/kg to reduce anxiety and tension experienced prior to... |
| Bromazepam | A short-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and severe anxiety. |
| Clotiazepam | For the treatment of anxiety disorders. |
| Chloral hydrate | A mild hypnotic used for experimental purposes that was previously used for the treatment of insomnia. |
| Fludiazepam | Used for the short-term treatment of anxiety disorders. |
| Ketazolam | A long-acting benzodiazepine used to manage anxiety and insomnia. |
| Prazepam | For the treatment of anxiety disorders. |
| Quazepam | A long -acting benzodiazepine used to manage insomnia. |
| Cinolazepam | For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms. |
| Nitrazepam | A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, insomnia, and seizures. |
| Periciazine | A phenothiazine used with other medications to treat aggressiveness, impulsiveness, and hostility associated with psychiatric conditions such as schizophrenia. |
| Acepromazine | Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and... |
| Molindone | An antipsychotic used to treat schizophrenia. |
| Pipotiazine | An antipsychotic indicated for the management of chronic, non-agitated schizophrenic patients. |
| Thioproperazine | An antipsychotic indicated for the management of acute and chronic schizophrenia, including cases that are refractory to more common neuroleptics. May also be used to treat manic syndromes. |
| Thiothixene | An antipsychotic indicated for the management of schizophrenia. |
| Zuclopenthixol | An antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance. |
| Methaqualone | For the treatment of insomnia, and as a sedative and muscle relaxant. |
| Fluspirilene | An antipsychotic agent used in the treatment of schizophrenia. |
| Iloperidone | An atypical antipsychotic agent used for the acute treatment of schizophrenia in adults. |
| Cariprazine | An atypical antipsychotic used to treat schizophrenia and acute manic or mixed episodes due to bipolar I disorder. |
| Sertindole | Used in the treatment of schizophrenia. |
| Asenapine | An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. |
| Amisulpride | Investigated for use/treatment in schizophrenia and schizoaffective disorders, mania in bipolar disorder, and depression. |
| Clomethiazole | Investigated for use/treatment in strokes. |
| Triclofos | Not Annotated |
| Mebutamate | Mebutamate is a sedative and anxiolytic drug with anti-hypertensive (blood pressure lowering) effects comparable to those of other barbiturates but is only around 1/3rd the potency of secobarbital as a... |
| Tofisopam | For the treatment of anxiety and alcohol withdrawal. |
| Lurasidone | An atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. |
| Etifoxine | Etifoxine is an anxiolytic and anticonvulsant drug developed by Hoechst in the 1960s. It is used in anxiety disorders and to promote peripheral nerve healing. It does not bind to... |
| Cyamemazine | Cyamemazine (Tercian), also known as cyamepromazine, is a typical antipsychotic drug of the phenothiazine class used primarily in the treatment of schizophrenia and psychosis-associated anxiety. Cyamemazine actually behaves like an... |
| Captodiame | Captodiame is indicated for the treatment of anxiety. |
| Brotizolam | Brotizolam is indicated for 2-4 weeks in the treatment of severe or debilitating insomnia. |
| Benzoctamine | Benzoctamine is a drug with two main uses. It can be used as a sedative which does not depress the respiratory system, but rather stimulates it. It can also be... |
| Tasimelteon | A melatonin receptor agonist used to treat Non- 24-Hour Sleep-Wake Disorder. |
| Paraldehyde | A central nervous system depressant previously used to control convulsions due to various clinical causes, including tetanus, status epilepticus, and convulsive drugs. |
| Brexpiprazole | A serotonin–dopamine activity modulator used in the treatment of major depressive disorder as an adjunct and schizophrenia. |
| Etizolam | Indicated for the treatment of generalized anxiety disorder with depression, panic disorder and insomnia. |
| Melperone | For the treatment of schizophrenia, sleep, disorders, agitation and mentally confused states [L1317, L1319, L1322]. |
| Zotepine | Zotepine, like other atypical antipsychotics, is considered as the first-line treatment in newly diagnosed schizophrenia. It is usually thought to be an option of choice for managing acute schizophrenic episodes... |
| Pipamperone | Treatment of chronic psychoses and states of aggressiveness of various origins . |
| Bromperidol | Bromperidol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others. |
| Perazine | Perazine has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others. |
| Benperidol | Benperidol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others. |
| Prothipendyl | Prothipendyl has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders. |
| Tiapride | Tiapride is indicated for the treatment of a variety of neurological and psychiatric disorders including dyskinesia, alcohol withdrawal syndrome, negative symptoms of psychosis, and agitation and aggression in the elderly. |
| Valnoctamide | Valnoctamide has been used in trials studying the treatment of Mania and Schizoaffective Disorder, Manic Type. |
| Valerian | A plant used in some non-prescription natural health products. |
| Butaperazine | Butaperazine was approved in 1967 , and possibly discontinued in the 1980s . |
| Apronalide | Apronalide is approved in Japan. Apronalide has been withdrawn from the market in many other countries due to patient development of thrombocytopenic purpura . |
| Proxibarbal | Proxibarbal is a derivative of barbiturates, which has been used to treat migraines. Proxibarbal was approved in France but was withdrawn from the market due to the risk of inducing... |
| Clothiapine | Clothiapine has been approved in European countries and is an atypical antipsychotic, shown to be useful in some treatment-resistant patients. |
| Sultopride | Sultopride is used in Japan, Hong Kong, and Europe to treat schizophrenia. It is of the drug class atypical antipsychotics . |
| Pyrithyldione | Not Annotated |
| Pinazepam | Not Annotated |
| Bromisoval | Not Annotated |
| Vinbarbital | Not Annotated |
| Chlorproethazine | Not Annotated |
| Acetylglycinamide chloral hydrate | Not Annotated |
| Oxypertine | Not Annotated |
| Medazepam | Not Annotated |
| Veralipride | Not Annotated |
| Gedocarnil | Not Annotated |
| Trifluperidol | Not Annotated |
| Moperone | Not Annotated |
| Thiopropazate | Not Annotated |
| Emylcamate | Not Annotated |
| Allobarbital | Not Annotated |
| Fabomotizole | Not Annotated |
| Loprazolam | Loprazolam is an imidazobenzodiazepine with anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It is indicated for the short-term treatment of insomnia including difficulty in falling asleep and/or frequent... |
| Hexapropymate | Not Annotated |
| Fluanisone | Not Annotated |
| Mosapramine | Not Annotated |
| Niaprazine | Niaprazine is a selective brain catecholamine depletor. |
| Methylpentynol | Not Annotated |
| Cyclobarbital | Not Annotated |
| Mephenoxalone | Not Annotated |
| Vinylbital | Not Annotated |
| Dixyrazine | Not Annotated |
| Penfluridol | Not Annotated |
| Reposal | Reposal is a barbiturate derivative invented in the 1960s in Denmark that has sedative, hypnotic and anticonvulsant properties. It was used primarily in the treatment of insomnia. |
| Carbromal | Not Annotated |
| Doxefazepam | Not Annotated |
| Clopenthixol | Clopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors. |
| Lormetazepam | For the treatment of short-term insomnia |
| Nordazepam | An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam. |
| Scopolamine | An anticholinergic used to treat excessive salivation, colicky abdominal pain, bradycardia, diverticulitis, IBS, and motion sickness. |
| Emepronium | Not Annotated |
| Chlorhexadol | Chlorhexadol is a sedative and hypnotic which is regulated in the United States as a Schedule III controlled substance. It is a derivative of chloral hydrate. |
| Pimavanserin | A second generation atypical antipsychotic used for the treatment of hallucinations and delusions caused by Parkinson's Disease. |
| Suvorexant | A orexin receptor antagonist used to treat insomnia that is characterized by difficulties with sleep onset and/or sleep maintenance. |
| Bentazepam | Not Annotated |
| Lithium carbonate | A medication used to treat manic episodes of bipolar disorder. |