This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Miocamycin
Accession Number
DB13287
Type
Biotech
Groups
Approved
Description

Miocamycin is a macrolide type antimicrobial 1. This drug may be marketed in Japan for clinical use as it is listed in the Japanese pharmacopeia 2. It has shown to be effective against several gram-positive and gram-negative microbes and may be useful in the treatment of upper and lower respiratory tract infections, and urogenital tract infections or as an alternative to erythromycin treatment 1.

Synonyms
  • Midecamycin acetate
Categories
UNII
3T48CPS7U2
CAS number
55881-07-7

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
(R)-warfarinThe risk or severity of bleeding can be increased when Miocamycin is combined with (R)-warfarin.
(S)-WarfarinThe risk or severity of bleeding can be increased when Miocamycin is combined with (S)-Warfarin.
3-isobutyl-1-methyl-7H-xanthineThe metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with Miocamycin.
3,5-diiodothyropropionic acidThe metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Miocamycin.
4-hydroxycoumarinThe metabolism of 4-hydroxycoumarin can be decreased when combined with Miocamycin.
5-androstenedioneThe metabolism of 5-androstenedione can be decreased when combined with Miocamycin.
6-O-benzylguanineThe metabolism of 6-O-benzylguanine can be decreased when combined with Miocamycin.
7-DeazaguanineThe metabolism of 7-Deazaguanine can be decreased when combined with Miocamycin.
7-ethyl-10-hydroxycamptothecinThe metabolism of 7-ethyl-10-hydroxycamptothecin can be decreased when combined with Miocamycin.
7,9-DimethylguanineThe metabolism of 7,9-Dimethylguanine can be decreased when combined with Miocamycin.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
Not Available

References

General References
  1. Holliday SM, Faulds D: Miocamycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic potential. Drugs. 1993 Oct;46(4):720-45. doi: 10.2165/00003495-199346040-00008. [PubMed:7506653]
  2. Kegg Japanese Pharmacopoeia [Link]
External Links
ChemSpider
16735908
ChEMBL
CHEMBL1091024
Wikipedia
Miocamycin
ATC Codes
J01FA11 — Miocamycin

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Taxonomy

Classification
Not classified

Enzymes

Kind
Protein
Organism
Humans
Pharmacological action
No
Actions
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Kuper JI, D'Aprile M: Drug-Drug interactions of clinical significance in the treatment of patients with Mycobacterium avium complex disease. Clin Pharmacokinet. 2000 Sep;39(3):203-14. [PubMed:11020135]

Drug created on June 23, 2017 14:39 / Updated on September 02, 2019 19:56