Macrolides

A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typically 12, 14, or 16)-membered lactone. Macrolides belong to the POLYKETIDES class of natural products, and many members exhibit ANTIBIOTIC properties.
DrugDrug NameDrug Description
DB00199ErythromycinA macrolide antibiotic used to treat and prevent a variety of bacterial infections.
DB00778RoxithromycinUsed to treat respiratory tract, urinary and soft tissue infections.
DB01321JosamycinFor the treatment of bacterial infections.
DB00954DirithromycinFor the treatment of the following mild-to-moderate infections caused by susceptible strains of microorganisms: acute bacterial exacerbations of chronic bronchitis, secondary bacterial infection of acute bronchitis, community-acquired pneumonia, pharyngitis/tonsilitis, and...
DB00976TelithromycinAn ketolide used to treat community acquired pneumonia of mild to moderate severity.
DB08874FidaxomicinA macrolide antibiotic used to treat diarrhea associated with Clostridium difficile.
DB09308SolithromycinInvestigated for the treatment of community-acquired pneumonia (CAP).
DB13179TroleandomycinFor the treatment of bacterial infection.
DB13287MiocamycinMiocamycin is a macrolide type antimicrobial . This drug may be marketed in Japan for clinical use as it is listed in the Japanese pharmacopeia . It has shown to...
DB13338FlurithromycinNot Annotated
DB13409RokitamycinNot Annotated
DB13456MidecamycinMidecamycin was used for the treatment of infections in the oral cavity, upper and lower respiratory tracts and skin and soft tissue infections. The alone use of midecamycin was mainly...
DB06145SpiramycinA macrolide antimicrobial agent used in the treatment of various bacterial infections.
DB00207AzithromycinA macrolide antibiotic used to treat a variety of bacterial infections.
DB01152CandicidinUsed in the topical treatment of vulvovaginal candidiasis.
DB01211ClarithromycinA macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection.
DB01590EverolimusA mammalian target of rapamycin (mTOR) kinase inhibitor used to treat various types of malignancies.
DB01873Epothilone DInvestigated for use/treatment in colorectal cancer, lung cancer, breast cancer, solid tumors, and prostate cancer.
DB03010PatupiloneInvestigated for use/treatment in ovarian cancer, lung cancer, brain cancer, breast cancer, and gastric cancer.
DB040706-Deoxyerythronolide BNot Available
DB04845IxabepiloneA microtubule inhibitor administered in combination with capecitabine or alone in the treatment of metastatic or locally advanced breast cancer that has shown inadequate response to taxanes and anthracyclines.
DB05903KOS-1584Investigated for use/treatment in solid tumors.
DB06233RidaforolimusInvestigated for use/treatment in solid tumors, sarcoma, cancer/tumors (unspecified), endometrial cancer, prostate cancer, and bone metastases.
DB06287TemsirolimusA antineoplastic agent used in the treatment of renal cell carcinoma (RCC) that works by inhibiting mTOR.
DB06318AVE9633Investigated for use/treatment in leukemia (myeloid).
DB06342Coltuximab ravtansineInvestigated for use/treatment in lymphoma (non-hodgkin's).
DB06419CethromycinInvestigated for use/treatment in bacterial infection, pediatric indications, and pneumonia.
DB06587MitemcinalInvestigated for use/treatment in gastroparesis and irritable bowel syndrome (IBS).
DB07348Brefeldin AA metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity.
DB09309KitasamycinKitasamycin is a macrolide antibiotic derived from Streptomyces kitasatoensis.
DB11383CarbomycinCarbomycin, also called magnamycin, is crystalline macrolide antibiotic. This antibacterial is obtained from Streptomyces halstedii and it presents a large inhibitory effect against Gram-positive bacteria and some Mycoplasma strains. The...
DB11400DoramectinDoramectin is a veterinary drug approved by the Food and Drug Administration for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in...
DB11405EprinomectinNot Annotated
DB11442OleandomycinOleandomycin is a macrolide antibiotic, though it is less effective than erythromycin. It is synthesized from strains of Streptomyces antibioticus.
DB11459SelamectinSelamectin is a topical parasiticide and antihelminthic used on dogs and cats to treat and prevent infections of heartworms, fleas, ear mites, sarcoptic mange, and certain types of ticks in...
DB11470TildipirosinNot Annotated
DB11471TilmicosinTilmicosin is a macrolide antibiotic. It is used in veterinary medicine for the treatment of bovine respiratory disease and ovine respiratory disease associated with Mannheimia haemolytica.
DB11475TylosinTylosin is a bacteriostatic macrolide antibiotic and feed additive used in veterinary medicine. It has a broad spectrum of activity against Gram-positive organisms and a limited range of Gram-negative organisms....
DB11554TylvalosinNot Annotated
DB11752Bryostatin 1Bryostatin 1 has been investigated for the treatment of HIV Infection and Alzheimer's Disease.
DB12089Lorvotuzumab mertansineLorvotuzumab mertansine has been used in trials studying the treatment of SCLC, Leukemia, Ovarian Cancer, Multiple Myeloma, and Merkel Cell Carcinoma, among others.
DB12266EpofolateEpofolate has been used in trials studying the treatment of Advanced Solid Tumors.
DB12391SagopiloneSagopilone has been used in trials studying the treatment of Melanoma, Neoplasms, CNS Disease, Breast Cancer, and Breast Neoplasms, among others. It is a so-called fully synthetic epothilone and is...
DB12489Mirvetuximab SoravtansineMirvetuximab Soravtansine has been used in trials studying the treatment of Ovarian cancer, Endometrial Cancer, Fallopian tube cancer, Epithelial Ovarian Cancer, and Primary Peritoneal Cancer, among others.
DB13633MepartricinNot Annotated
DB00877SirolimusAn immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis.
DB15527UmirolimusNot Annotated
DrugDrug NameTargetType
DB00199Erythromycin23S ribosomal RNAtarget
DB00199ErythromycinCytochrome P450 3A4enzyme
DB00199ErythromycinCytochrome P450 3A7enzyme
DB00199ErythromycinP-glycoprotein 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1B1transporter
DB00199ErythromycinMotilin receptortarget
DB00199ErythromycinPotassium voltage-gated channel subfamily H member 2target
DB00199ErythromycinCytochrome P450 3A5enzyme
DB00199ErythromycinSolute carrier organic anion transporter family member 1B3transporter
DB00199ErythromycinBile salt export pumptransporter
DB00199ErythromycinCanalicular multispecific organic anion transporter 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1A2transporter
DB00778Roxithromycin50S ribosomal protein L10target
DB00778RoxithromycinP-glycoprotein 1target
DB00778RoxithromycinCytochrome P450 3A4enzyme
DB00778RoxithromycinCytochrome P450 2B6enzyme
DB01321Josamycin50S ribosomal protein L4target
DB00954Dirithromycin23S ribosomal RNAtarget
DB00954DirithromycinCytochrome P450 3A4enzyme
DB00976Telithromycin23S ribosomal RNAtarget
DB00976TelithromycinCytochrome P450 3A4enzyme
DB00976TelithromycinSolute carrier organic anion transporter family member 1B1transporter
DB00976TelithromycinSolute carrier organic anion transporter family member 1B3transporter
DB08874FidaxomicinP-glycoprotein 1transporter
DB08874FidaxomicinRNA polymerase sigma factortarget
DB08874FidaxomicinCytochrome P450 3A4enzyme
DB09308SolithromycinCytochrome P450 3A4enzyme
DB13179TroleandomycinCytochrome P450 3A5enzyme
DB13179TroleandomycinCytochrome P450 3A43enzyme
DB13179Troleandomycin50S ribosomal protein L4target
DB13179Troleandomycin50S ribosomal protein L32target
DB13179TroleandomycinP-glycoprotein 1transporter
DB13179TroleandomycinCytochrome P450 2C8enzyme
DB13179TroleandomycinCytochrome P450 3A4enzyme
DB13179TroleandomycinNuclear receptor subfamily 1 group I member 2target
DB13179TroleandomycinCytochrome P450 3A7enzyme
DB13287MiocamycinCytochrome P450 3A4enzyme
DB13338FlurithromycinCytochrome P450 3A4enzyme
DB13409RokitamycinCytochrome P450 3A4enzyme
DB13456MidecamycinCytochrome P450 3A4enzyme
DB06145Spiramycin50S ribosomal protein L3target
DB00207Azithromycin23S ribosomal RNAtarget
DB00207AzithromycinP-glycoprotein 1transporter
DB00207AzithromycinCytochrome P450 3A4enzyme
DB00207AzithromycinProtein-arginine deiminase type-4target
DB00207AzithromycinCanalicular multispecific organic anion transporter 1transporter
DB01152CandicidinErgosteroltarget
DB01152CandicidinCytochrome P450 3A4enzyme
DB01211Clarithromycin50S ribosomal protein L10target
DB01211ClarithromycinCytochrome P450 3A4enzyme
DB01211ClarithromycinCytochrome P450 3A5enzyme
DB01211ClarithromycinP-glycoprotein 1transporter
DB01211ClarithromycinSolute carrier family 22 member 7transporter
DB01211ClarithromycinPotassium voltage-gated channel subfamily H member 2target
DB01211ClarithromycinSolute carrier organic anion transporter family member 1B1target
DB01211ClarithromycinSolute carrier organic anion transporter family member 1B3target
DB01211ClarithromycinBile salt export pumptransporter
DB01590EverolimusSerine/threonine-protein kinase mTORtarget
DB01590EverolimusCytochrome P450 3A4enzyme
DB01590EverolimusSolute carrier organic anion transporter family member 1B1transporter
DB01590EverolimusSolute carrier organic anion transporter family member 1B3transporter
DB01590EverolimusSolute carrier organic anion transporter family member 1A2transporter
DB01590EverolimusCytochrome P450 2D6enzyme
DB01873Epothilone DTubulin alpha-3C/D chaintarget
DB01873Epothilone DTubulin beta chaintarget
DB01873Epothilone DTubulin beta-1 chaintarget
DB01873Epothilone DTubulin beta-4B chaintarget
DB01873Epothilone DTubulin beta-4A chaintarget
DB01873Epothilone DTubulin alpha-4A chaintarget
DB01873Epothilone DTubulin beta-3 chaintarget
DB01873Epothilone DTubulin alpha-1C chaintarget
DB01873Epothilone DTubulin alpha-8 chaintarget
DB01873Epothilone DTubulin alpha-1B chaintarget
DB01873Epothilone DTubulin alpha-1A chaintarget
DB01873Epothilone DCytochrome P450 3A4enzyme
DB03010PatupiloneTubulin alpha-3C/D chaintarget
DB03010PatupiloneTubulin beta chaintarget
DB03010PatupiloneTubulin beta-1 chaintarget
DB03010PatupiloneTubulin beta-4B chaintarget
DB03010PatupiloneTubulin beta-4A chaintarget
DB03010PatupiloneTubulin alpha-4A chaintarget
DB03010PatupiloneTubulin beta-3 chaintarget
DB03010PatupiloneTubulin alpha-1C chaintarget
DB03010PatupiloneTubulin alpha-8 chaintarget
DB03010PatupiloneTubulin alpha-1B chaintarget
DB03010PatupiloneTubulin alpha-1A chaintarget
DB03010PatupiloneCytochrome P450 3A4enzyme
DB040706-Deoxyerythronolide B6-deoxyerythronolide B hydroxylasetarget
DB040706-Deoxyerythronolide BCytochrome P450 3A4enzyme
DB04845IxabepiloneTubulin beta-3 chaintarget
DB04845IxabepiloneCytochrome P450 3A4enzyme
DB05903KOS-1584Cytochrome P450 3A4enzyme
DB06233RidaforolimusSerine/threonine-protein kinase mTORtarget
DB06233RidaforolimusCytochrome P450 3A4enzyme
DB06287TemsirolimusSerine/threonine-protein kinase mTORtarget
DB06287TemsirolimusCytochrome P450 3A4enzyme
DB06287TemsirolimusCytochrome P450 3A5enzyme
DB06287TemsirolimusCytochrome P450 3A7enzyme
DB06287TemsirolimusCytochrome P450 2D6enzyme
DB06287TemsirolimusP-glycoprotein 1transporter
DB06318AVE9633Myeloid cell surface antigen CD33target
DB06318AVE9633Cytochrome P450 3A4enzyme
DB06342Coltuximab ravtansineB-lymphocyte antigen CD19target
DB06342Coltuximab ravtansineCytochrome P450 3A4enzyme
DB06419Cethromycin23S ribosomal RNAtarget
DB06419CethromycinCytochrome P450 3A5enzyme
DB06419CethromycinCytochrome P450 3A4enzyme
DB06587MitemcinalMotilin receptortarget
DB06587MitemcinalCytochrome P450 3A4enzyme
DB07348Brefeldin ACytohesin-2target
DB07348Brefeldin AADP-ribosylation factor 1target
DB07348Brefeldin ACytochrome P450 3A4enzyme
DB09309KitasamycinCytochrome P450 3A4enzyme
DB11383CarbomycinCytochrome P450 3A4enzyme
DB11400DoramectinCytochrome P450 3A4enzyme
DB11405EprinomectinCytochrome P450 3A4enzyme
DB11442OleandomycinCytochrome P450 3A4enzyme
DB11459SelamectinCytochrome P450 3A4enzyme
DB11470TildipirosinCytochrome P450 3A4enzyme
DB11471TilmicosinCytochrome P450 3A4enzyme
DB11475TylosinCytochrome P450 3A4enzyme
DB11554TylvalosinCytochrome P450 3A4enzyme
DB11752Bryostatin 1Cytochrome P450 3A4enzyme
DB12089Lorvotuzumab mertansineCytochrome P450 3A4enzyme
DB12266EpofolateCytochrome P450 3A4enzyme
DB12391SagopiloneCytochrome P450 3A4enzyme
DB12489Mirvetuximab SoravtansineCytochrome P450 3A4enzyme
DB13633MepartricinCytochrome P450 3A4enzyme
DB00877SirolimusPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
DB00877SirolimusCytochrome P450 3A4enzyme
DB00877SirolimusSerine/threonine-protein kinase mTORtarget
DB00877SirolimusFibroblast growth factor 2target
DB00877SirolimusCytochrome P450 3A5enzyme
DB00877SirolimusCytochrome P450 3A7enzyme
DB00877SirolimusP-glycoprotein 1transporter
DB00877SirolimusSolute carrier organic anion transporter family member 1B1transporter
DB00877SirolimusMultidrug and toxin extrusion protein 1transporter