Endometritis

Also known as: Endometritis unspecified / Endometritis NOS

DrugDrug NameDrug Description
DB00493CefotaximeCefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various trade names including Claforan (Sanofi-Aventis).
DB01331CefoxitinCefoxitin is a semi-synthetic, broad-spectrum cepha antibiotic for intravenous administration. It is derived from cephamycin C, which is produced by Streptomyces lactamdurans.
DB01190ClindamycinClindamycin is a semisynthetic lincosamide antibiotic that has largely replaced lincomycin due to an improved side effect profile. Clindamycin inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits. It may be bacteriostatic or bactericidal depending on the organism and drug concentration.
DB00916MetronidazoleA nitroimidazole used to treat amebiasis; vaginitis; trichomonas infections; giardiasis; anaerobic bacteria; and treponemal infections. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).
DrugDrug NameTargetType
DB00493CefotaximePenicillin-binding protein 3target
DB00493CefotaximeSolute carrier family 15 member 1transporter
DB00493CefotaximeSolute carrier family 15 member 2transporter
DB00493CefotaximeSolute carrier family 22 member 6transporter
DB00493CefotaximeSolute carrier family 22 member 8transporter
DB00493CefotaximeSolute carrier family 22 member 11transporter
DB00493CefotaximeSolute carrier family 22 member 7transporter
DB00493CefotaximePenicillin-binding protein 1btarget
DB00493CefotaximePenicillin-binding protein 2atarget
DB00493CefotaximePenicillin-binding protein 1Atarget
DB00493CefotaximePenicillin-binding protein 2Btarget
DB00493CefotaximeSolute carrier family 22 member 6target
DB00493CefotaximeSolute carrier family 22 member 8target
DB00493CefotaximeSolute carrier family 22 member 11target
DB00493CefotaximeSolute carrier family 22 member 7target
DB00493CefotaximeSolute carrier family 15 member 1target
DB00493CefotaximeSerum albumintarget
DB00493CefotaximeBeta-lactamasetarget
DB00493CefotaximeSolute carrier family 15 member 2target
DB01331CefoxitinBeta-lactamaseenzyme
DB01331CefoxitinPenicillin-binding protein 1Atarget
DB01331CefoxitinPenicillin-binding protein 1Btarget
DB01331CefoxitinPeptidoglycan synthase FtsItarget
DB01331CefoxitinD-alanyl-D-alanine carboxypeptidase DacAtarget
DB01331CefoxitinD-alanyl-D-alanine carboxypeptidase DacBtarget
DB01331CefoxitinD-alanyl-D-alanine carboxypeptidase DacCtarget
DB01331CefoxitinD-alanyl-D-alanine endopeptidasetarget
DB01331CefoxitinPenicillin-binding protein 3target
DB01331CefoxitinPenicillin-binding protein 1btarget
DB01331CefoxitinPenicillin-binding protein 2atarget
DB01331CefoxitinPenicillin-binding protein 1Atarget
DB01331CefoxitinPenicillin-binding protein 2Btarget
DB01190Clindamycin50S ribosomal protein L10target
DB01190ClindamycinCytochrome P450 3A4enzyme
DB01190Clindamycin23S rRNAtarget
DB00916MetronidazoleIron hydrogenase 1target
DB00916MetronidazoleDNAtarget
DB00916MetronidazoleOxygen-insensitive NADPH nitroreductasetarget
DB00916MetronidazoleCytochrome P450 2C9enzyme
DB00916MetronidazoleCytochrome P450 3A4enzyme
DB00916MetronidazoleCytochrome P450 2C8enzyme
DB00916MetronidazoleLanosterol 14-alpha demethylasetarget
DrugDrug NamePhaseStatusCount
DB00303Ertapenem1Terminated1
DB01212Ceftriaxone2Not Yet Recruiting1
DB00207Azithromycin4Withdrawn1
DB01327Cefazolin4Withdrawn1
DB00415AmpicillinNot AvailableUnknown Status1
DB00207AzithromycinNot AvailableCompleted2
DB01327CefazolinNot AvailableCompleted1
DB01190ClindamycinNot AvailableUnknown Status1
DB00353MethylergometrineNot AvailableCompleted1
DB09153Sodium ChlorideNot AvailableActive Not Recruiting1