Infections, Streptococcus Pneumoniae

Also known as: Streptococcus pneumoniae infection / Streptococcus Pneumoniae Infections / Pneumoniae Infections, Streptococcus / Pneumococcal infection NOS / Pneumococcal Infections / Pneumococcal infection / Pneumococcal disease

DrugDrug NameDrug Description
DB00207AzithromycinAzithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration [A174172]. It was initially approved by the FDA in 1991 [A174175]. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually transmitted and enteric infections. It is structurally related to erythromycin [A174169]. Azithromycin [9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin] is a part of the _azalide_ subclass of macrolides, and contains a 15-membered ring, with a methyl-substituted nitrogen instead of a carbonyl group at the 9a position on the aglycone ring, which allows for the prevention of its metabolism. This differentiates azithromycin from other types of macrolides [A174175].
DB00254DoxycyclineDoxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline [FDA label]. This drug is a second-generation tetracycline, exhibiting lesser toxicity than first-generation tetracyclines [A174034]. Doxycycline may be used to treat a wide range of bacterial infections, depending on the results of antibiotic susceptibility testing.
DB00199ErythromycinErythromycin is a bacteriostatic antibiotic drug produced by a strain of Saccharopolyspora erythraea (formerly Streptomyces erythraeus) and belongs to the macrolide group of antibiotics which consists of [Azithromycin], [Clarithromycin], [Spiramycin] and others. It was originally discovered in 1952.[L5245] Erythromycin is widely used for treating a variety of infections, including those caused by gram-positive and gram-negative bacteria.[L5245,L7261] It is available for administration in various forms, including intravenous, topical, and eye drop preparations.[L5245]
DB12455OmadacyclineOmadacycline has been used in trials studying the treatment of Bacterial Pneumonia, Bacterial Infections, Community-Acquired Infections, and Skin Structures and Soft Tissue Infections. Omadacycline represents a significant advance over the well-known tetracycline family, and has been shown to be highly effective in animal models at treating increasingly problematic, clinically prevalent infections caused by gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), and by gram-negative, atypical and anaerobic bacteria, including those resistant to currently available classes of antibiotics and known to cause diseases such as pneumonias, urinary tract infections, skin diseases and blood-borne infections in both the hospital and community settings.
DrugDrug NameTargetType
DB00207Azithromycin23S rRNAtarget
DB00207AzithromycinMultidrug resistance protein 1transporter
DB00207AzithromycinCytochrome P450 3A4enzyme
DB00207AzithromycinProtein-arginine deiminase type-4target
DB00207AzithromycinCanalicular multispecific organic anion transporter 1transporter
DB00254Doxycycline16S rRNAtarget
DB00254DoxycyclineSolute carrier family 22 member 6transporter
DB00254DoxycyclineCytochrome P450 3A4enzyme
DB00254DoxycyclineATP-binding cassette sub-family B member 5transporter
DB00199Erythromycin23S rRNAtarget
DB00199ErythromycinCytochrome P450 3A4enzyme
DB00199ErythromycinCytochrome P450 3A7enzyme
DB00199ErythromycinMultidrug resistance protein 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1B1transporter
DB00199ErythromycinMotilin receptortarget
DB00199ErythromycinPotassium voltage-gated channel subfamily H member 2target
DB00199ErythromycinCytochrome P450 3A5enzyme
DB00199ErythromycinSolute carrier organic anion transporter family member 1B3transporter
DB00199ErythromycinBile salt export pumptransporter
DB00199ErythromycinCanalicular multispecific organic anion transporter 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1A2transporter
DB12455OmadacyclineMultidrug resistance protein 1transporter
DB12455Omadacycline30S ribosomal protein S3target
DB12455Omadacycline30S ribosomal protein S7target
DB12455Omadacycline30S ribosomal protein S8target
DB12455Omadacycline30S ribosomal protein S19target
DB12455Omadacycline30S ribosomal protein S14target
DB12455Omadacycline16S rRNAtarget
DB12455OmadacyclineSerum albumincarrier
DrugDrug NamePhaseStatusCount
DB09877Corynebacterium diphtheriae1 / 2Completed1
DB10319Streptococcus pneumoniae type 1 capsular polysaccharide antigen1 / 2Completed1
DB10332Streptococcus pneumoniae type 14 capsular polysaccharide antigen1 / 2Completed1
DB10335Streptococcus pneumoniae type 18c capsular polysaccharide antigen1 / 2Completed1
DB10337Streptococcus pneumoniae type 19a capsular polysaccharide antigen1 / 2Completed1
DB10336Streptococcus pneumoniae type 19f capsular polysaccharide antigen1 / 2Completed1
DB10340Streptococcus pneumoniae type 23f capsular polysaccharide antigen1 / 2Completed1
DB10321Streptococcus pneumoniae type 3 capsular polysaccharide antigen1 / 2Completed1
DB10322Streptococcus pneumoniae type 4 capsular polysaccharide antigen1 / 2Completed1
DB10323Streptococcus pneumoniae type 5 capsular polysaccharide antigen1 / 2Completed1
DB10296Streptococcus pneumoniae type 6a capsular polysaccharide diphtheria crm197 protein conjugate antigen1 / 2Completed1
DB10324Streptococcus pneumoniae type 6b capsular polysaccharide antigen1 / 2Completed1
DB10325Streptococcus pneumoniae type 7f capsular polysaccharide antigen1 / 2Completed1
DB10328Streptococcus pneumoniae type 9v capsular polysaccharide antigen1 / 2Completed1
DB10293Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria crm197 protein conjugate antigen2 / 3Recruiting1
DB10293Streptococcus pneumoniae type 1 capsular polysaccharide diphtheria crm197 protein conjugate antigen4Recruiting1
DB10289Streptococcus pneumoniae type 14 capsular polysaccharide diphtheria crm197 protein conjugate antigen4Recruiting1
DB10290Streptococcus pneumoniae type 18c capsular polysaccharide diphtheria crm197 protein conjugate antigen4Recruiting1
DB10298Streptococcus pneumoniae type 19a capsular polysaccharide diphtheria crm197 protein conjugate antigen4Recruiting1
DB10291Streptococcus pneumoniae type 19f capsular polysaccharide diphtheria crm197 protein conjugate antigen4Recruiting1
DB10292Streptococcus pneumoniae type 23f capsular polysaccharide diphtheria crm197 protein conjugate antigen4Recruiting1
DB10294Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria crm197 protein conjugate antigen4Recruiting1
DB10286Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria crm197 protein conjugate antigen4Completed1
DB10286Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria crm197 protein conjugate antigen4Recruiting1
DB10295Streptococcus pneumoniae type 5 capsular polysaccharide diphtheria crm197 protein conjugate antigen4Recruiting1
DB10296Streptococcus pneumoniae type 6a capsular polysaccharide diphtheria crm197 protein conjugate antigen4Recruiting1
DB10287Streptococcus pneumoniae type 6b capsular polysaccharide diphtheria crm197 protein conjugate antigen4Recruiting1
DB10297Streptococcus pneumoniae type 7f capsular polysaccharide diphtheria crm197 protein conjugate antigen4Recruiting1
DB10288Streptococcus pneumoniae type 9v capsular polysaccharide diphtheria crm197 protein conjugate antigen4Recruiting1