Skin and Subcutaneous Tissue Bacterial Infections

Also known as: Complicated Skin and Skin Structure Infections / Skin and subcutaneous tissue bacterial infection / Skin and skin structure infections / Complicated Skin and Skin Structure Infection

DrugDrug NameDrug Description
DB00479AmikacinAn aminoglycoside used to treat infections caused by more resistant strains of Gram negative bacteria and some Gram positive bacteria.
DB01060AmoxicillinA penicillin derivative used for the treatment of infections caused by gram-positive bacteria, in particular streptococcal bacteria causing upper respiratory tract infections.
DB01140CefadroxilA cephalosporin antibiotic used in the treatment of various bacterial infections, such as urinary tract infections, skin and skin structure infections, and tonsillitis.
DB01327CefazolinA broad-spectrum cephalosporin antibiotic mainly used for the treatment of skin bacterial infections and other moderate to severe bacterial infections in the lung, bone, joint, stomach, blood, heart valve, and urinary tract.
DB00493CefotaximeA third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections.
DB01331CefoxitinA semi-synthetic, broad-spectrum antibiotic for parenteral administration used for the treatment of serious bacterial infections, such as urinary tract infection, blood infection, bone and joint infection, and lower respiratory tract infection.
DB01212CeftriaxoneA broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections at various locations, such as in the respiratory tract, skin, soft tissue, and urinary tract.
DB01112CefuroximeA cephalosporin indicated for the treatment of a variety of infections including acute bacterial otitis media, several upper respiratory tract infections, skin infections, urinary tract infections, gonorrhea, early Lyme disease, and impetigo.
DB00567CephalexinA first generation cephalosporin used to treat certain susceptible bacterial infections.
DB01597CilastatinA renal dehydropeptidase inhibitor used to prevent degradation of imipenem. Both medications are used together to treat a variety of infections.
DB00766Clavulanic acidA beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics.
DB01190ClindamycinAn antibiotic used to treat serious infections caused by susceptible anaerobic bacteria, such as intra-abdominal or pelvic infections, osteomyelitis, diabetic foot ulcers, and dental infections.
DB06219DalbavancinAn antibacterial used to treat acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible strains of Gram-positive bacteria.
DB00080DaptomycinA cyclic lipopeptide antibiotic used to treat complicated skin infections and bacteremia due to Staphylococcus aureus.
DB00798GentamicinAn aminoglycoside used to treat a wide variety of infections in the body.
DB01598ImipenemA carbapenem antibiotic normally administered with cilastatin to treat a variety of infections.
DB00601LinezolidAn oxazolidinone antibiotic used to treat susceptible strains of multidrug resistant bacterial infections.
DB00916MetronidazoleA nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections.
DB01017MinocyclineA tetracycline analog used to treat a wide variety of infections in the body.
DB01165OfloxacinAn antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract.
DB04911OritavancinAn antibacterial agent used to treat acute bacterial skin and skin structure infections caused by susceptible Gram-positive bacteria.
DB00417PhenoxymethylpenicillinA penicillin antibiotic used to prevent and treat mild to moderately severe infections in the respiratory tract, skin, and soft tissues.
DB09320Procaine benzylpenicillinA local anesthetic and antibiotic combination for intramuscular injection to treat a variety of bacterial infections while reducing pain from a deep intramuscular injection.
DB09324SulbactamAn beta-lactamase inhibitor antibiotic combined with other antibiotics to treat a variety of susceptible bacterial infections.
DB00759TetracyclineAn antibiotic used to treat a wide variety of susceptible infections.
DB00560TigecyclineA glycylcycline antibiotic used to treat a number of susceptible bacterial infections.
DB00684TobramycinAn aminoglycoside antibiotic used to treat cystic fibrosis, lung infections, eye infections, and a variety of other infections.
DrugDrug NameTargetType
DB00479Amikacin30S ribosomal protein S12target
DB01060AmoxicillinPenicillin-binding protein 1Atarget
DB01060AmoxicillinSolute carrier family 15 member 1transporter
DB01060AmoxicillinSolute carrier family 15 member 2transporter
DB01060AmoxicillinSolute carrier family 22 member 6transporter
DB01140CefadroxilSolute carrier family 22 member 5transporter
DB01140CefadroxilSolute carrier family 15 member 1transporter
DB01140CefadroxilSolute carrier family 15 member 2transporter
DB01140CefadroxilSolute carrier family 22 member 6transporter
DB01140CefadroxilSolute carrier family 22 member 8transporter
DB01140CefadroxilPenicillin-binding protein 3target
DB01140CefadroxilPenicillin-binding protein 1Atarget
DB01140CefadroxilPenicillin-binding protein 1btarget
DB01140CefadroxilPenicillin-binding protein 2Btarget
DB01327CefazolinSerum paraoxonase/arylesterase 1target
DB01327CefazolinSerum albumincarrier
DB01327CefazolinSolute carrier family 22 member 6transporter
DB01327CefazolinSolute carrier family 22 member 8transporter
DB01327CefazolinSolute carrier family 22 member 11transporter
DB01327CefazolinPenicillin-binding protein 1Atarget
DB01327CefazolinPenicillin-binding protein 1Btarget
DB01327CefazolinPenicillin-binding protein 2target
DB01327CefazolinPenicillin-binding protein 1Ctarget
DB01327CefazolinPeptidoglycan synthase FtsItarget
DB01327CefazolinMultidrug resistance-associated protein 4transporter
DB01327CefazolinThiopurine S-methyltransferaseenzyme
DB01327CefazolinInterleukin-15target
DB01327CefazolinInterleukin-2target
DB00493CefotaximePenicillin-binding protein 3target
DB00493CefotaximeSolute carrier family 15 member 1transporter
DB00493CefotaximeSolute carrier family 15 member 2transporter
DB00493CefotaximeSolute carrier family 22 member 6transporter
DB00493CefotaximeSolute carrier family 22 member 8transporter
DB00493CefotaximeSolute carrier family 22 member 11transporter
DB00493CefotaximeSolute carrier family 22 member 7transporter
DB00493CefotaximePenicillin-binding protein 1btarget
DB00493CefotaximePenicillin-binding protein 2atarget
DB00493CefotaximePenicillin-binding protein 1Atarget
DB00493CefotaximePenicillin-binding protein 2Btarget
DB00493CefotaximeSolute carrier family 22 member 6target
DB00493CefotaximeSolute carrier family 22 member 8target
DB00493CefotaximeSolute carrier family 22 member 11target
DB00493CefotaximeSolute carrier family 22 member 7target
DB00493CefotaximeSolute carrier family 15 member 1target
DB00493CefotaximeSerum albumintarget
DB00493CefotaximeBeta-lactamasetarget
DB00493CefotaximeSolute carrier family 15 member 2target
DB01331CefoxitinPenicillin-binding protein 1Atarget
DB01331CefoxitinPenicillin-binding protein 1Btarget
DB01331CefoxitinPeptidoglycan synthase FtsItarget
DB01331CefoxitinD-alanyl-D-alanine carboxypeptidase DacAtarget
DB01331CefoxitinD-alanyl-D-alanine carboxypeptidase DacBtarget
DB01331CefoxitinD-alanyl-D-alanine carboxypeptidase DacCtarget
DB01331CefoxitinD-alanyl-D-alanine endopeptidasetarget
DB01331CefoxitinBeta-lactamaseenzyme
DB01331CefoxitinPenicillin-binding protein 3target
DB01331CefoxitinPenicillin-binding protein 1btarget
DB01331CefoxitinPenicillin-binding protein 2atarget
DB01331CefoxitinPenicillin-binding protein 1Atarget
DB01331CefoxitinPenicillin-binding protein 2Btarget
DB01212CeftriaxoneSerum albumincarrier
DB01212CeftriaxoneSolute carrier family 15 member 1transporter
DB01212CeftriaxoneSolute carrier family 15 member 2transporter
DB01212CeftriaxoneSolute carrier family 22 member 6transporter
DB01212CeftriaxoneSolute carrier family 22 member 8transporter
DB01212CeftriaxoneSolute carrier family 22 member 11transporter
DB01212CeftriaxonePenicillin-binding protein 2Btarget
DB01212CeftriaxoneGlutamine synthetaseenzyme
DB01212CeftriaxoneSolute carrier family 22 member 11target
DB01212CeftriaxoneSolute carrier family 22 member 6target
DB01212CeftriaxoneSolute carrier family 22 member 8target
DB01212CeftriaxoneSolute carrier family 15 member 1target
DB01112CefuroximePenicillin-binding protein 1Atarget
DB01112CefuroximeSolute carrier family 15 member 1transporter
DB01112CefuroximeSolute carrier family 15 member 2transporter
DB00567CephalexinSerum albumincarrier
DB00567CephalexinSolute carrier family 22 member 5transporter
DB00567CephalexinSolute carrier family 15 member 1transporter
DB00567CephalexinSolute carrier family 15 member 2transporter
DB00567CephalexinSolute carrier family 22 member 6transporter
DB00567CephalexinSolute carrier family 22 member 8transporter
DB00567CephalexinMultidrug and toxin extrusion protein 1transporter
DB00567CephalexinPenicillin-binding protein 3target
DB00567CephalexinPenicillin-binding protein 2atarget
DB00567CephalexinPenicillin-binding protein 1btarget
DB00567CephalexinPenicillin-binding protein 1Atarget
DB00567CephalexinPenicillin-binding protein 2Btarget
DB01597CilastatinDipeptidase 1target
DB01597CilastatinSolute carrier family 22 member 6transporter
DB01597CilastatinSolute carrier family 22 member 8transporter
DB00766Clavulanic acidBacterial beta-lactamase enzymesenzyme
DB00766Clavulanic acidBacterial beta-lactamase enzymestarget
DB00766Clavulanic acidSodium/glucose cotransporter 1transporter
DB01190Clindamycin50S ribosomal protein L10target
DB01190ClindamycinCytochrome P450 3A4enzyme
DB01190Clindamycin23S ribosomal RNAtarget
DB06219DalbavancinD-Ala-D-Ala moiety of NAM/NAG peptide subunits of peptidoglycantarget
DB00080DaptomycinBacterial outer membranetarget
DB00798Gentamicin30S ribosomal protein S12target
DB00798Gentamicin16S ribosomal RNAtarget
DB00798GentamicinLow-density lipoprotein receptor-related protein 2target
DB00798GentamicinSolute carrier family 22 member 6transporter
DB00798GentamicinNH(3)-dependent NAD(+) synthetasetarget
DB00798GentamicinDihydrofolate reductasetarget
DB01598ImipenemPenicillin-binding protein 1Atarget
DB01598ImipenemPenicillin-binding protein 1Btarget
DB01598ImipenemPenicillin-binding protein 2target
DB01598ImipenemPenicillin-binding protein 3target
DB01598ImipenemDipeptidase 1enzyme
DB01598ImipenemPenicillin-binding protein 4target
DB01598ImipenemBeta-lactamase SHV-1enzyme
DB01598ImipenemBeta-lactamase TEMenzyme
DB01598ImipenemBeta-lactamase CTX-Menzyme
DB01598ImipenemBeta-lactamase (KPC-2)enzyme
DB00601Linezolid23S ribosomal RNAtarget
DB00601LinezolidAmine oxidase [flavin-containing] Aenzyme
DB00601LinezolidAmine oxidase [flavin-containing] Benzyme
DB00916MetronidazoleOxygen-insensitive NADPH nitroreductasetarget
DB00916MetronidazoleCytochrome P450 2C9enzyme
DB00916MetronidazoleCytochrome P450 3A4enzyme
DB00916MetronidazoleCytochrome P450 2C8enzyme
DB00916MetronidazoleUDP-glucuronosyltransferase 1-1enzyme
DB00916MetronidazoleAnaerobic bacterial DNAtarget
DB00916MetronidazoleProtozoal DNAtarget
DB00916MetronidazoleP-glycoprotein 1transporter
DB00916MetronidazoleCytochrome P450 2A6enzyme
DB00916MetronidazoleCytochrome P450 3A5enzyme
DB00916MetronidazoleCytochrome P450 3A7enzyme
DB01017Minocycline30S ribosomal protein S4target
DB01017Minocycline30S ribosomal protein S9target
DB01017Minocycline16S ribosomal RNAtarget
DB01017MinocyclineInterleukin-1 betatarget
DB01017MinocyclineArachidonate 5-lipoxygenasetarget
DB01017MinocyclineMatrix metalloproteinase-9target
DB01017MinocyclineVascular endothelial growth factor Atarget
DB01017MinocyclineCaspase-1target
DB01017MinocyclineCaspase-3target
DB01017MinocyclineCytochrome ctarget
DB01017MinocyclineSolute carrier family 22 member 6transporter
DB01017MinocyclineSolute carrier family 22 member 8transporter
DB01017MinocyclineSolute carrier family 22 member 11transporter
DB01017MinocyclineSolute carrier family 22 member 7transporter
DB01165OfloxacinDNA gyrase subunit Atarget
DB01165OfloxacinDNA topoisomerase 4 subunit Atarget
DB01165OfloxacinDNA topoisomerase 2-alphatarget
DB01165OfloxacinCytochrome P450 1A2enzyme
DB01165OfloxacinSolute carrier family 22 member 5transporter
DB01165OfloxacinMultidrug resistance-associated protein 1transporter
DB01165OfloxacinSolute carrier family 22 member 6transporter
DB01165OfloxacinCanalicular multispecific organic anion transporter 1transporter
DB01165OfloxacinSolute carrier family 22 member 4transporter
DB01165OfloxacinBile salt export pumptransporter
DB04911OritavancinCytochrome P450 3A4enzyme
DB04911OritavancinCytochrome P450 2D6enzyme
DB04911OritavancinCytochrome P450 2C9enzyme
DB04911OritavancinCytochrome P450 2C19enzyme
DB00417PhenoxymethylpenicillinPenicillin-binding protein 1Atarget
DB00417PhenoxymethylpenicillinMecA PBP2' (penicillin binding protein 2')target
DB00417PhenoxymethylpenicillinD-alanyl-D-alanine carboxypeptidase DacBtarget
DB00417PhenoxymethylpenicillinPenicillin acylasetarget
DB00417PhenoxymethylpenicillinSolute carrier family 15 member 1target
DB09324SulbactamBeta-lactamasetarget
DB00759Tetracycline16S ribosomal RNAtarget
DB00759TetracyclineMajor prion proteintarget
DB00759TetracyclineSerum albumincarrier
DB00759TetracyclineCytochrome P450 3A4enzyme
DB00759TetracyclineSolute carrier family 22 member 6transporter
DB00759TetracyclineSolute carrier family 22 member 8transporter
DB00759TetracyclineSolute carrier family 22 member 11transporter
DB00759TetracyclineSolute carrier family 22 member 7transporter
DB00759Tetracycline30S ribosomal protein S3target
DB00759Tetracycline30S ribosomal protein S8target
DB00759Tetracycline30S ribosomal protein S19target
DB00759Tetracycline30S ribosomal protein S14target
DB00759Tetracycline30S ribosomal protein S7target
DB00759TetracyclineMultidrug translocase MdfAtarget
DB00759TetracyclineProtein-arginine deiminase type-4target
DB00759TetracyclineSolute carrier organic anion transporter family member 2B1transporter
DB00560Tigecycline30S ribosomal protein S9target
DB00560Tigecycline16S ribosomal RNAtarget
DB00560Tigecycline30S ribosomal protein S14target
DB00560Tigecycline30S ribosomal protein S13target
DB00560Tigecycline30S ribosomal protein S19target
DB00560Tigecycline30S ribosomal protein S12target
DB00684Tobramycin30S ribosomal protein S12target
DB00684Tobramycin16S ribosomal RNAtarget
DB00684TobramycinAminoglycoside 2'-N-acetyltransferaseenzyme
DrugDrug NamePhaseStatusCount
DB12658AFN-12522Completed1
DB11943Delafloxacin2Completed1
DB00601Linezolid2Completed2
DB00512Vancomycin2Completed1
DB00512Vancomycin2Recruiting1
DB00355Aztreonam3Completed2
DB01914D-glucose3Completed1
DB11943Delafloxacin3Completed2
DB06358Iclaprim3Completed1
DB00601Linezolid3Completed3
DB14569Tedizolid3Completed1
DB09042Tedizolid phosphate3Completed1
DB00512Vancomycin3Completed2
DB01053Benzylpenicillin4Terminated1
DB00878Chlorhexidine4Recruiting1
DB01147Cloxacillin4Terminated1
DB00080Daptomycin4Terminated1
DB00410Mupirocin4Recruiting1
DB00607Nafcillin4Terminated1
DB00713Oxacillin4Terminated1
DB00512Vancomycin4Terminated1
DB00802AlfentanilNot AvailableRecruiting1
DB00479AmikacinNot AvailableRecruiting1
DB00513Aminocaproic acidNot AvailableRecruiting1
DB00559BosentanNot AvailableRecruiting1
DB01413CefepimeNot AvailableRecruiting1
DB00369CidofovirNot AvailableRecruiting1
DB00537CiprofloxacinNot AvailableRecruiting1
DB00363ClozapineNot AvailableRecruiting1
DB00828FosfomycinNot AvailableRecruiting1
DB00502HaloperidolNot AvailableRecruiting1
DB00598LabetalolNot AvailableRecruiting1
DB08815LurasidoneNot AvailableRecruiting1
DB00959MethylprednisoloneNot AvailableRecruiting1
DB01618MolindoneNot AvailableRecruiting1
DB00607NafcillinNot AvailableRecruiting1
DB01115NifedipineNot AvailableRecruiting1
DB00497OxycodoneNot AvailableRecruiting1
DB00312PentobarbitalNot AvailableRecruiting1
DB00319PiperacillinNot AvailableRecruiting1
DB00728RocuroniumNot AvailableRecruiting1
DB00658SevelamerNot AvailableRecruiting1
DB00421SpironolactoneNot AvailableRecruiting1
DB01606TazobactamNot AvailableRecruiting1
DB06402TelavancinNot AvailableCompleted1
DB00560TigecyclineNot AvailableCompleted2
DB00684TobramycinNot AvailableRecruiting1
DB00302Tranexamic acidNot AvailableRecruiting1
DB00512VancomycinNot AvailableRecruiting1
DB01339VecuroniumNot AvailableRecruiting1
DB00682WarfarinNot AvailableRecruiting1
DB00246ZiprasidoneNot AvailableRecruiting1
DB00425ZolpidemNot AvailableRecruiting1