Triosephosphate isomerase

Details

Name
Triosephosphate isomerase
Synonyms
  • 5.3.1.1
  • TIM
  • TPI
  • Triose-phosphate isomerase
Gene Name
TPI1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0037263|Triosephosphate isomerase
MAEDGEEAEFHFAALYISGQWPRLRADTDLQRLGSSAMAPSRKFFVGGNWKMNGRKQSLG
ELIGTLNAAKVPADTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGM
IKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKV
VFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQ
STRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPEFVDIINAKQ
Number of residues
286
Molecular Weight
30790.785
Theoretical pI
6.91
GO Classification
Functions
triose-phosphate isomerase activity / ubiquitin protein ligase binding
Processes
canonical glycolysis / carbohydrate metabolic process / gluconeogenesis / glucose metabolic process / glyceraldehyde-3-phosphate biosynthetic process / glycerol catabolic process / glycolytic process / multicellular organismal development / pentose-phosphate shunt / small molecule metabolic process
Components
cytosol / extracellular exosome / extracellular space / nucleus
General Function
Ubiquitin protein ligase binding
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0017243|Triosephosphate isomerase (TPI1)
ATGGCGCCCTCCAGGAAGTTCTTCGTTGGGGGAAACTGGAAGATGAACGGGCGGAAGCAG
AGTCTGGGGGAGCTCATCGGCACTCTGAACGCGGCCAAGGTGCCGGCCGACACCGAGGTG
GTTTGTGCTCCCCCTACTGCCTATATCGACTTCGCCCGGCAGAAGCTAGATCCCAAGATT
GCTGTGGCTGCGCAGAACTGCTACAAAGTGACTAATGGGGCTTTTACTGGGGAGATCAGC
CCTGGCATGATCAAAGACTGCGGAGCCACGTGGGTGGTCCTGGGGCACTCAGAGAGAAGG
CATGTCTTTGGGGAGTCAGATGAGCTGATTGGGCAGAAAGTGGCCCATGCTCTGGCAGAG
GGACTCGGAGTAATCGCCTGCATTGGGGAGAAGCTAGATGAAAGGGAAGCTGGCATCACT
GAGAAGGTTGTTTTCGAGCAGACAAAGGTCATCGCAGATAACGTGAAGGACTGGAGCAAG
GTCGTCCTGGCCTATGAGCCTGTGTGGGCCATTGGTACTGGCAAGACTGCAACACCCCAA
CAGGCCCAGGAAGTACACGAGAAGCTCCGAGGATGGCTGAAGTCCAACGTCTCTGATGCG
GTGGCTCAGAGCACCCGTATCATTTATGGAGGCTCTGTGACTGGGGCAACCTGCAAGGAG
CTGGCCAGCCAGCCTGATGTGGATGGCTTCCTTGTGGGTGGTGCTTCCCTCAAGCCCGAA
TTCGTGGACATCATCAATGCCAAACAATGA
Chromosome Location
12
Locus
12p13
External Identifiers
ResourceLink
UniProtKB IDP60174
UniProtKB Entry NameTPIS_HUMAN
GenBank Protein ID339841
GenBank Gene IDM10036
HGNC IDHGNC:12009
General References
  1. Maquat LE, Chilcote R, Ryan PM: Human triosephosphate isomerase cDNA and protein structure. Studies of triosephosphate isomerase deficiency in man. J Biol Chem. 1985 Mar 25;260(6):3748-53. [PubMed:2579079]
  2. Brown JR, Daar IO, Krug JR, Maquat LE: Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family. Mol Cell Biol. 1985 Jul;5(7):1694-706. [PubMed:4022011]
  3. Ansari-Lari MA, Muzny DM, Lu J, Lu F, Lilley CE, Spanos S, Malley T, Gibbs RA: A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. Genome Res. 1996 Apr;6(4):314-26. [PubMed:8723724]
  4. Ansari-Lari MA, Shen Y, Muzny DM, Lee W, Gibbs RA: Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. Genome Res. 1997 Mar;7(3):268-80. [PubMed:9074930]
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  9. Lu HS, Yuan PM, Gracy RW: Primary structure of human triosephosphate isomerase. J Biol Chem. 1984 Oct 10;259(19):11958-68. [PubMed:6434534]
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  28. Kinoshita T, Maruki R, Warizaya M, Nakajima H, Nishimura S: Structure of a high-resolution crystal form of human triosephosphate isomerase: improvement of crystals using the gel-tube method. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Apr 1;61(Pt 4):346-9. Epub 2005 Mar 24. [PubMed:16511037]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01695N-Hydroxy-4-Phosphono-ButanamideexperimentalunknownDetails
DB03026Phosphoglycolohydroxamic AcidexperimentalunknownDetails
DB03135[2(Formyl-Hydroxy-Amino)-Ethyl]-Phosphonic AcidexperimentalunknownDetails
DB033145-fluorotryptophanexperimentalunknownDetails
DB033792-Carboxyethylphosphonic AcidexperimentalunknownDetails
DB039002-Methyl-2-PropanolexperimentalunknownDetails
DB04326Dihydroxyacetone phosphateinvestigationalunknownDetails
DB044471,4-DithiothreitolexperimentalunknownDetails
DB045103-phospho-D-glyceric acidexperimentalunknownDetails
DB027262-Phosphoglycolic AcidexperimentalunknownDetails
DB073873-(BUTYLSULPHONYL)-PROPANOIC ACIDexperimentalunknownDetails
DB031323-(2-Benzothiazolylthio)-1-Propanesulfonic AcidexperimentalunknownDetails
DB01593Zincapproved, investigationalunknownDetails
DB11638Artenimolexperimental, investigationalunknownligandDetails
DB14487Zinc acetateapproved, investigationalunknownDetails
DB14533Zinc chlorideapproved, investigationalunknownDetails