Displaying drugs 3526 - 3550 of 11741 in total
Maribavir
Maribavir is an inhibitor of the cytomegalovirus (CMV; HHV5) pUL97 kinase which is used to treat CMV infections in patients post-transplantation. Most standard CMV therapies, such as ganciclovir or foscarnet, target CMV DNA polymerase - while generally effective, these medications tend to promote the development of CMV resistance to DNA...
Approved
Investigational
Nedosiran
Nedosiran is an RNA interference targeting hepatic lactate dehydrogenase, the enzyme responsible for the conversion of glyoxylate to oxalate. Oxalate, particularly calcium oxalate, precipitation is the main cause of kidney stones formation; therefore, blocking the production of oxalate can help alleviate renal symptoms. Nedosiran was approved by the FDA on...
Approved
Investigational
Glucosamine
Osteoarthritis (OA) is a progressive and degenerative joint disease marked by loss of cartilage, bone changes, and synovial membrane inflammation. Treatment with chondroprotective drugs, such as glucosamine sulfate may offer additional benefits to nonsteroidal anti-inflammatory drugs treating the painful symptoms of OA. Glucosamine is commonly used over the counter as...
Approved
Investigational
Matched Description: … Osteoarthritis (OA) is a progressive and degenerative joint disease marked by loss of cartilage, bone ... as a medical therapy varies due to contradictory and findings with unclear clinical significance during ... Glucosamine is commonly used over the counter as a treatment for arthritic joint pain, although its acceptance …
Tolterodine
Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors.
Approved
Investigational
Lenacapavir
HIV/AIDS remains an area of concern despite the introduction of numerous successful therapies, mainly due to the emergence of multidrug resistance and patient difficulty in adhering to treatment regimens.[A244170, A244175] Lenacapavir is a first-in-class capsid inhibitor that demonstrates picomolar HIV-1 inhibition as a monotherapy in vitro, little to no cross-resistance...
Approved
Investigational
Matched Description: … [A244170, A244175] Lenacapavir is a first-in-class capsid inhibitor that demonstrates picomolar HIV-1 ... inhibition as a monotherapy _in vitro_, little to no cross-resistance with existing antiretroviral agents …
Fluclorolone acetonide
Fluclorolone acetonide (INN) or flucloronide (USAN) is a topical corticosteroid. It is marketed under the brand names Cutanit and Topicon.
Approved
Withdrawn
Matched Description: … Fluclorolone acetonide (INN) or flucloronide (USAN) is a topical corticosteroid. …
Acer saccharinum pollen
Acer saccharinum pollen is the pollen of the Acer saccharinum plant. Acer saccharinum pollen is mainly used in allergenic testing.
Approved
Iva angustifolia pollen
Iva angustifolia pollen is the pollen of the Iva angustifolia plant. Iva angustifolia pollen is mainly used in allergenic testing.
Approved
Efbemalenograstim alfa
Efbemalenograstim alfa is a long-acting recombinant fusion protein of granulocyte-colony stimulating factor (G-CSF) due to the addition of the Fc portion of human IgG2, allowing for once-per-cycle administration.[L48852,A262167] As endogenous G-CSF mediates the differentiation of hematopoietic stem cells into granulocytes and eventually neutrophils, the administration of recombinant G-CSF like efbemalenograstim...
Approved
Matched Description: … Efbemalenograstim alfa is a long-acting recombinant fusion protein of granulocyte-colony stimulating ... patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a …
Tenofovir disoproxil
Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name Viread, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs). This drug is prescribed in combination with other drugs for the management of HIV infection as well as for...
Approved
Investigational
Matched Description: … Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name ... _Viread_, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase …
Pilocarpine
A naturally occurring alkaloid derived from the Pilocarpus plants, pilocarpine is a muscarinic acetylcholine agonist.[A262016, A262036] Pilocarpine is associated with parasympathomimetic effects by selectively working on muscarinic receptors. Pilocarpine is used to treat dry mouth and various ophthalmic conditions, including elevated intraocular pressure and glaucoma. The usage of glaucoma by...
Approved
Investigational
Matched Description: … A naturally occurring alkaloid derived from the _Pilocarpus_ plants, pilocarpine is a muscarinic acetylcholine …
Cystine
A covalently linked dimeric nonessential amino acid formed by the oxidation of cysteine. Two molecules of cysteine are joined together by a disulfide bridge to form cystine.
Approved
Nutraceutical
Matched Description: … A covalently linked dimeric nonessential amino acid formed by the oxidation of cysteine. ... Two molecules of cysteine are joined together by a disulfide bridge to form cystine. …
Ropeginterferon alfa-2b
Polycythemia vera (PV) is the most common Philadelphia chromosome-negative myeloproliferative neoplasm (MPN), characterized by increased hematocrit and platelet/leukocyte counts, an increased risk for hemorrhage and thromboembolic events, and a long-term propensity for myelofibrosis and leukemia.[A242000, A242005] Interferon alfa-2b has been used for decades to treat PV but requires frequent dosing...
Approved
Investigational
Matched Description: … proline-IFN-α-2b in _Escherichia coli_ that has high tolerability and a long half-life. ... [A242005] Ropeginterferon alfa-2b is a next-generation mono-pegylated type I interferon produced from ... hematocrit and platelet/leukocyte counts, an increased risk for hemorrhage and thromboembolic events, and a …
Anthrax immune globulin human
Anthrax immune globulin is a human antibody given with antibiotics for the treatment of anthrax. It is derived from the plasma of humans immunized with BioThrax (adsorbed anthrax vaccine), which is then further purified. Available as the product Anthrasil (FDA), the result is a solution for slow IV infusion containing...
Approved
Matched Description: … Anthrax immune globulin is a human antibody given with antibiotics for the treatment of anthrax. ... Available as the product Anthrasil (FDA), the result is a solution for slow IV infusion containing polyclonal …
Nelarabine
Nelarabine is an antineoplastic agent that is typically used to treat acute T-cell lymphoblastic leukemia, particularly T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL), in both adult and pediatric patients whose disease has not responded to or has relapsed following at least two chemotherapy regimens. T-cell acute lymphoblastic...
Approved
Investigational
Matched Description: … Due to the rarity of these T-cell malignancies, nelarabine was first granted orphan drug status and a ... [A2331]
Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine ... Results from 2 phase 2 studies on adult and pediatric T-ALL/T-LBL indicated that nelarabine can yield a …
Dimethicone 410
Dimethicone is a silicone-based polymer used as a moisturizer in different skin OTC products. It is formed by repeated polymeric units of -(CH3)2SiO- with a terminal trimethyl siloxy unit. It is currently recognized by the FDA as a skin protectant OTC ingredient for human use in a concentration of 1-30%....
Approved
Matched Description: … Dimethicone is a silicone-based polymer used as a moisturizer in different skin OTC products. ... [L1769] It is currently recognized by the FDA as a skin protectant OTC ingredient for human use in a ... [A32462] It is formed by repeated polymeric units of -(CH3)2SiO- with a terminal trimethyl siloxy unit …
Zuclopenthixol
Zuclopenthixol, also known as Zuclopentixol or Zuclopenthixolum, is an antipsychotic agent. Zuclopenthixol is a thioxanthene-based neuroleptic with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors. Major brands of zuclopenthixol are Cisordinol, Acuphase, and Clopixol. This drug is a liquid. This compound...
Approved
Investigational
Matched Description: … This drug is a liquid. This compound belongs to the thioxanthenes. ... derived from xanthene by replacing the oxygen atom with a sulfur atom. ... Zuclopenthixol is a thioxanthene-based neuroleptic with therapeutic actions similar to the phenothiazine …
Dioctyldimonium
Approved
Experimental
Mivacurium
Mivacurium is a bisbenzylisoquinolinium based neuromuscular blocker or muscle relaxant. It binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in a block of neuromuscular transmission.
Approved
Matched Description: … Mivacurium is a bisbenzylisoquinolinium based neuromuscular blocker or muscle relaxant. ... cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in a …
Istradefylline
Istradefylline, or KW6002, was developed by Kyowa Hakko Kirin in Japan for the treatment of Parkinson's disease as an adjunct to standard therapy. Unlike standard dopaminergic therapies for Parkinson's, Istradefylline targets adenosine A2A receptors in the basal ganglia. This region of the brain is highly involved in motor control. Istradefylline...
Approved
Investigational
Matched Description: … [A184067] Unlike standard dopaminergic therapies for Parkinson's, Istradefylline targets adenosine A< …
Brinzolamide
Brinzolamide is a highly specific, non-competitive, reversible carbonic anhydrase II (CA-II) inhibitor indicated to reduce ocular pressure in patients with ocular hypertension or open-angle glaucoma. Although the exact pathophysiology of glaucoma is still unknown, one of the main hallmarks of this disease is vascular dysregulation and abnormalities.[A2049,A2051] The resulting vascular...
Approved
Matched Description: … [A2051] Brinzolamide was approved by the FDA in 1998 as a standalone product and in 2013 as a combination ... Brinzolamide is a highly specific, non-competitive, reversible carbonic anhydrase II (CA-II) inhibitor ... [L35310,L35315] In Europe, it was also approved as a combination product with timolol in 2008. …
Salix lasiolepis pollen
Salix lasiolepis pollen is the pollen of the Salix lasiolepis plant. Salix lasiolepis pollen is mainly used in allergenic testing.
Approved
Displaying drugs 3526 - 3550 of 11741 in total